518-82-1 | Emodin

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$11.00	$8.00
1g	98%	in stock	$26.00	$18.00
5g	98%	in stock	$39.00	$28.00
10g	98%	in stock	$68.00	$48.00
25g	98%	in stock	$116.00	$82.00
100g	98%	in stock	$418.00	$292.00

Description

• Catalog Number: AI51608
• Chemical Name: Emodin
• CAS Number: 518-82-1
• Molecular Formula: C15H10O5
• Molecular Weight: 270.2369
• MDL Number: MFCD00001207
• SMILES: Cc1cc(O)c2c(c1)C(=O)c1c(C2=O)c(O)cc(c1)O

Computed Properties

• Complexity: 434
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• XLogP3: 2.7

Literature

• From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity.

  Toxicological sciences : an official journal of the Society of Toxicology 20180201

• From the Cover: Aloin, a Component of the Aloe Vera Plant Leaf, Induces Pathological Changes and Modulates the Composition of Microbiota in the Large Intestines of F344/N Male Rats.

  Toxicological sciences : an official journal of the Society of Toxicology 20170801

• Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes.

  Toxicology in vitro : an international journal published in association with BIBRA 20170401

• Emodin suppresses TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells through Notch signaling pathway.

  Toxicology and applied pharmacology 20170301

• Chemical Reactivity of Emodin and Its Oxidative Metabolites to Thiols.

  Chemical research in toxicology 20161219

• The natural anthraquinones from Rheum palmatum induced the metabolic disorder of melatonin by inhibiting human CYP and SULT enzymes.

  Toxicology letters 20161116

• Involvement of PI3K/Akt, ERK and p38 signaling pathways in emodin-mediated extrinsic and intrinsic human hepatoblastoma cell apoptosis.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20160601

• Emodin isolated from Polygoni Multiflori Ramulus inhibits melanogenesis through the liver X receptor-mediated pathway.

  Chemico-biological interactions 20160425

• Emodin Attenuates Cigarette Smoke Induced Lung Injury in a Mouse Model via Suppression of Reactive Oxygen Species Production.

  Journal of biochemical and molecular toxicology 20151101

• Involvement of PPARγ in emodin-induced HK-2 cell apoptosis.

  Toxicology in vitro : an international journal published in association with BIBRA 20150201

• Emodin inhibits human sperm functions by reducing sperm [Ca(2+)]i and tyrosine phosphorylation.

  Reproductive toxicology (Elmsford, N.Y.) 20150101

• In vitro glucuronidation of five rhubarb anthraquinones by intestinal and liver microsomes from humans and rats.

  Chemico-biological interactions 20140805

• Antitubercular and antibacterial activity of quinonoid natural products against multi-drug resistant clinical isolates.

  Phytotherapy research : PTR 20140701

• Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: herb-drug interactions mediated via P-gp.

  Toxicology and applied pharmacology 20140301

• Inhibition of Epstein-Barr virus lytic cycle by an ethyl acetate subfraction separated from Polygonum cuspidatum root and its major component, emodin.

  Molecules (Basel, Switzerland) 20140120

• Exploration of effects of emodin in selected cancer cell lines: enhanced growth inhibition by ascorbic acid and regulation of LRP1 and AR under hypoxia-like conditions.

  Journal of applied toxicology : JAT 20140101

• Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3.

  British journal of pharmacology 20131001

• Protective effects of emodin against cisplatin-induced oxidative stress in cultured human kidney (HEK 293) cells.

  Journal of applied toxicology : JAT 20130701

• Long-term treatment with san'o-shashin-to, a kampo medicine, markedly ameliorates cardiac ischemia-reperfusion injury in ovariectomized rats via the redox-dependent mechanism.

  Circulation journal : official journal of the Japanese Circulation Society 20130101

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4.

  Immunopharmacology and immunotoxicology 20121001

• Use of cetyltrimethylammonium bromide as a simple probe for rapid determination of emodin by resonance light scattering technique.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121001

• Irbesartan and emodin on myocardial remodeling in Goldblatt hypertensive rats.

  Journal of cardiovascular pharmacology 20121001

• Bioactive anthraquinones from endophytic fungus Aspergillus versicolor isolated from red sea algae.

  Archives of pharmacal research 20121001

• A new herb-drug interaction of Polygonum cuspidatum, a resveratrol-rich nutraceutical, with carbamazepine in rats.

  Toxicology and applied pharmacology 20120915

• Emodin induces embryonic toxicity in mouse blastocysts through apoptosis.

  Toxicology 20120904

• Determination of emodin by hexadecyl trimethyl ammonium bromide sensitized fluorescence quenching method of the derivatives of calix[4]arene.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120901

• Emodin, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice.

  Acta pharmacologica Sinica 20120901

• A strategy for detecting absorbed bioactive compounds for quality control in the water extract of rhubarb by ultra performance liquid chromatography with photodiode array detector.

  Chinese journal of integrative medicine 20120901

• Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats.

  Chinese journal of integrative medicine 20120901

• A new polymorph of physcion.

  Acta crystallographica. Section C, Crystal structure communications 20120801

• Effects of an anthraquinone derivative from Rheum officinale Baill, emodin, on airway responses in a murine model of asthma.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120701

• Discovery and structure-activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2.

  Bioorganic & medicinal chemistry letters 20120701

• Emodin, a naturally occurring anthraquinone, ameliorates experimental autoimmune myocarditis in rats.

  The Tohoku journal of experimental medicine 20120701

• Study of DNA-emodin interaction by FTIR and UV-vis spectroscopy.

  Journal of photochemistry and photobiology. B, Biology 20120604

• Emodin potentiates the antitumor effects of gemcitabine in PANC-1 pancreatic cancer xenograft model in vivo via inhibition of inhibitors of apoptosis.

  International journal of oncology 20120601

• Emodin inhibits tumor necrosis factor-α-induced migration and inflammatory responses in rat aortic smooth muscle cells.

  International journal of molecular medicine 20120601

• A novel UPLC-MS/MS method for simultaneous quantification of rhein, emodin, berberine and baicalin in rat plasma and its application in a pharmacokinetic study.

  Bioanalysis 20120601

• Library-based discovery of DYRK1A/CLK1 inhibitors from natural product extracts.

  Planta medica 20120601

• Emodin protects against high-fat diet-induced obesity via regulation of AMP-activated protein kinase pathways in white adipose tissue.

  Planta medica 20120601

• Screening of anti-cancer agent using zebrafish: comparison with the MTT assay.

  Biochemical and biophysical research communications 20120525

• Emodin promoted pancreatic claudin-5 and occludin expression in experimental acute pancreatitis rats.

  World journal of gastroenterology 20120507

• Effects of emodin and vitamin C on growth performance, biochemical parameters and two HSP70s mRNA expression of Wuchang bream (Megalobrama amblycephala Yih) under high temperature stress.

  Fish & shellfish immunology 20120501

• Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: roles of apoptotic cell death and LS1034 tumor xenografts model.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501

• On the novel action of melanolysis by a leaf extract of Aloe vera and its active ingredient aloin, potent skin depigmenting agents.

  Planta medica 20120501

• [Emodin combined gemcitabine inhibited the growth of pancreatic cancer in vitro and in vivo and its mechanisms study].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120501

• [Chemical constituents of Dolomiaea souliei].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501

• [Rapid cloning and functional characterization of hypericin synthase gene].

  Yao xue xue bao = Acta pharmaceutica Sinica 20120501

• Emodin reverses gemcitabine resistance in pancreatic cancer cells via the mitochondrial apoptosis pathway in vitro.

  International journal of oncology 20120401

• Toxicity of raw and processed roots of Polygonum multiflorum.

  Fitoterapia 20120401

• Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.

  Bioorganic & medicinal chemistry 20120401

• Characteristics of emodin on modulating the contractility of jejunal smooth muscle.

  Canadian journal of physiology and pharmacology 20120401

• Hepatoprotection of emodin and Polygonum multiflorum against CCl(4)-induced liver injury.

  Pharmaceutical biology 20120301

• A facile synthesis of emodin derivatives, emodin carbaldehyde, citreorosein, and their 10-deoxygenated derivatives and their inhibitory activities on μ-calpain.

  Archives of pharmacal research 20120301

• Inhibition of cytochrome p450 enzymes by quinones and anthraquinones.

  Chemical research in toxicology 20120220

• Apoptosis by aloe-emodin is mediated through down-regulation of calpain-2 and ubiquitin-protein ligase E3A in human hepatoma Huh-7 cells.

  Cell biology international 20120201

• Structural and functional analysis of the flexible regions of the catalytic α-subunit of protein kinase CK2.

  Journal of structural biology 20120201

• [Chemical constituents of Berchemia lineate].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20120201

• Microwave-assisted extraction performed in low temperature and in vacuo for the extraction of labile compounds in food samples.

  Analytica chimica acta 20120127

• Simultaneous determination of eight anthraquinones in Semen Cassiae by HPLC-DAD.

  Phytochemical analysis : PCA 20120101

• Emodin induces chloride secretion in rat distal colon through activation of mast cells and enteric neurons.

  British journal of pharmacology 20120101

• Rhein induces apoptosis in human breast cancer cells.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Chemical-based species classification of rhubarb using simultaneous determination of five bioactive substances by HPLC and LDA analysis.

  Phytochemical analysis : PCA 20120101

• Synthesis and antitumor activity of conjugates of 5-Fluorouracil and emodin.

  European journal of medicinal chemistry 20120101

• Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity.

  Bioorganic & medicinal chemistry letters 20120101

• Comparison of dispersive liquid-liquid microextraction based on organic solvent and ionic liquid combined with high-performance liquid chromatography for the analysis of emodin and its metabolites in urine samples.

  Journal of separation science 20120101

• Identification of small molecule activators of the janus kinase/signal transducer and activator of transcription pathway using a cell-based screen.

  Biological & pharmaceutical bulletin 20120101

• Emodin prevents intrahepatic fat accumulation, inflammation and redox status imbalance during diet-induced hepatosteatosis in rats.

  International journal of molecular sciences 20120101

• Enhancement of fluoride activity against Streptococcus mutans biofilms by a substance separated from Polygonum cuspidatum.

  Biofouling 20120101

• Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6/p38 and MEK7/JNK Pathways.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Emodin, a Naturally Occurring Anthraquinone Derivative, Ameliorates Dyslipidemia by Activating AMP-Activated Protein Kinase in High-Fat-Diet-Fed Rats.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Formulation, antileukemia mechanism, pharmacokinetics, and biodistribution of a novel liposomal emodin.

  International journal of nanomedicine 20120101

• [Determination of four anthraquinones in Sanhuang tablets by QAMS].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120101

• Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis.

  PloS one 20120101

• Emodin affects ERCC1 expression in breast cancer cells.

  Journal of translational medicine 20120101

• Screening medicinal plants for the detection of novel antimalarial products applying the inhibition of β-hematin formation.

  Journal of pharmaceutical and biomedical analysis 20111215

• Emodin-induced microglial apoptosis is associated with TRB3 induction.

  Immunopharmacology and immunotoxicology 20111201

• Antitumor and apoptosis-promoting properties of emodin, an anthraquinone derivative from Rheum officinale Baill, against pancreatic cancer in mice via inhibition of Akt activation.

  International journal of oncology 20111201

• Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm.

  Journal of medical microbiology 20111201

• Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation.

  Biochemical pharmacology 20111201

• Surface-initiated molecularly imprinted polymeric column: In situ synthesis and application for semi-preparative separation by high performance liquid chromatography.

  Journal of chromatography. A 20111111

• Toxicological effect of emodin in mouse testicular gene expression profile.

  Journal of applied toxicology : JAT 20111101

• Comparative analyses of chromatographic fingerprints of the roots of Polygonum multiflorum Thunb. and their processed products using RRLC/DAD/ESI-MS(n).

  Planta medica 20111101

• Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo.

  International journal of oncology 20111101

• Emodin potentiates the anticancer effect of cisplatin on gallbladder cancer cells through the generation of reactive oxygen species and the inhibition of survivin expression.

  Oncology reports 20111101

• Development of a liquid chromatography tandem mass spectrometry method for simultaneous determination of eight adulterants in slimming functional foods.

  Journal of chromatography. A 20111021

• Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata.

  Journal of ethnopharmacology 20111011

• A comparative study on the tissue distributions of rhubarb anthraquinones in normal and CCl4-injured rats orally administered rhubarb extract.

  Journal of ethnopharmacology 20111011

• Blockade of Her2/neu binding to Hsp90 by emodin azide methyl anthraquinone derivative induces proteasomal degradation of Her2/neu.

  Molecular pharmaceutics 20111003

• Repair and reconstruction of a resected tumor defect using a composite of tissue flap-nanotherapeutic-silk fibroin and chitosan scaffold.

  Annals of biomedical engineering 20110901

• In vitro accelerated mass propagation and ex vitro evaluation of Aloe vera L. with aloin content and superoxide dismutase activity.

  Natural product research 20110801

• Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.

  Bioorganic & medicinal chemistry letters 20110715

• Development and validation of a highly rapid and sensitive LC-MS/MS method for determination of SZ-685C, an investigational marine anticancer agent, in rat plasma--application to a pharmacokinetic study in rats.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110715

• The use of response surface methodology to optimize the ultrasound-assisted extraction of five anthraquinones from Rheum palmatum L.

  Molecules (Basel, Switzerland) 20110715

• [Chemical constituents of Carya cathayensis and their antitumor bioactivity].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110701

• Hepatitis C virus and alcohol: same mitotic targets but different signaling pathways.

  Journal of hepatology 20110501

• Enhanced effect of gemcitabine by emodin against pancreatic cancer in vivo via cytochrome C-regulated apoptosis.

  Oncology reports 20110501

• Emodin and [6]-gingerol lessen hypoxia-induced embryotoxicities in cultured mouse whole embryos via upregulation of hypoxia-inducible factor 1α and intracellular superoxide dismutases.

  Reproductive toxicology (Elmsford, N.Y.) 20110501

• Inhibition of experimental atopic dermatitis by rhubarb (rhizomes of Rheum tanguticum) and 5-lipoxygenase inhibition of its major constituent, emodin.

  Phytotherapy research : PTR 20110501

• [Alkaloids and anthraquinones from branches and leaves of uvaria kurzii].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110501

• Sensitive and robust UPLC-MS/MS method to determine the gender-dependent pharmacokinetics in rats of emodin and its glucuronide.

  Journal of pharmaceutical and biomedical analysis 20110405

• Effect of emodin on neuropathic pain transmission mediated by P2X2/3 receptor of primary sensory neurons.

  Brain research bulletin 20110405

• Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells.

  Journal of cellular biochemistry 20110401

• [Effect of emodin combined gemcitabine on the growth and apoptosis of pancreatic cancer cell line BxPC-3 in vitro].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20110401

• Apoptotic effect of Polygonum Cuspidatum in oral cancer cells through the regulation of specificity protein 1.

  Oral diseases 20110301

• Modulation of Rad51, ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabine.

  Biochemical pharmacology 20110301

• [Tissue distribution of free anthraquinones in SD rats after orally administered extracts from raw and prepared rhubarbs].

  Yao xue xue bao = Acta pharmaceutica Sinica 20110301

• [Studies on identification and secondary metabolites of endophytic fungi strain E8 from Curcuma wenyujin].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110301

• Variable responses of different human cancer cells to the lichen compounds parietin, atranorin, usnic acid and gyrophoric acid.

  Toxicology in vitro : an international journal published in association with BIBRA 20110201

• Solid-phase extraction and ultra high-performance liquid chromatography tandem mass spectrometry analysis of the gastrointestinal absorption of emodin in different digestive segments of rats.

  Journal of separation science 20110201

• [Role of nuclear factor-kappaB on emodin-induced sensitization of pancreatic cancer to gemcitabine].

  Yao xue xue bao = Acta pharmaceutica Sinica 20110201

• The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo.

  Journal of ethnopharmacology 20110127

• Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer.

  Journal of medicinal chemistry 20110127

• Preparative isolation of three anthraquinones from Rumex japonicus by high-speed counter-current chromatography.

  Molecules (Basel, Switzerland) 20110127

• Selective determination of aloin in different matrices by HPTLC densitometry in fluorescence mode.

  Journal of pharmaceutical and biomedical analysis 20110125

• Effects of food and gender on the pharmacokinetics of rhein and emodin in rats after oral dosing with Da-Cheng-Qi decoction.

  Phytotherapy research : PTR 20110101

• New anthraquinone dimer from the root bark of Cassia artemisioides (Gaudich. Ex. DC) Randell.

  Journal of Asian natural products research 20110101

• Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plants.

  PloS one 20110101

• Emodin potentiates the antitumor effects of gemcitabine in pancreatic cancer cells via inhibition of nuclear factor-κB.

  Molecular medicine reports 20110101

• Emodin inhibits extracellular matrix synthesis by suppressing p38 and ERK1/2 pathways in TGF-β1-stimulated NRK-49F cells.

  Molecular medicine reports 20110101

• Endocrocin and its derivatives from the Japanese mealybug Planococcus kraunhiae.

  Bioscience, biotechnology, and biochemistry 20110101

• Effect of clone selection, nitrogen supply, leaf damage and mycorrhizal fungi on stilbene and emodin production in knotweed.

  BMC plant biology 20110101

• Emodin Induces Apoptotic Death in Murine Myelomonocytic Leukemia WEHI-3 Cells In Vitro and Enhances Phagocytosis in Leukemia Mice In Vivo.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Emodin inhibits proinflammatory responses and inactivates histone deacetylase 1 in hypoxic rheumatoid synoviocytes.

  Biological & pharmaceutical bulletin 20110101

• Combined phytochemistry and chemotaxis assays for identification and mechanistic analysis of anti-inflammatory phytochemicals in Fallopia japonica.

  PloS one 20110101

• Anthraquinones of Cissus populnea Guill & Perr (Amplidaceae).

  African journal of traditional, complementary, and alternative medicines : AJTCAM 20110101

• Approach toward the total synthesis of 5-hydroxyaloin A.

  Organic letters 20101217

• Emodin suppresses lipopolysaccharide-induced pro-inflammatory responses and NF-κB activation by disrupting lipid rafts in CD14-negative endothelial cells.

  British journal of pharmacology 20101201

• Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II.

  Toxicological sciences : an official journal of the Society of Toxicology 20101201

• The anthraquinone derivative emodin attenuates methamphetamine-induced hyperlocomotion and startle response in rats.

  Pharmacology, biochemistry, and behavior 20101201

• [Determination of rat serum emodin level by microemulsion liquid chromatography with direct sample loading].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20101201

• [Emodin enhances antitumor effect of gemcitabine in model of SW1990 cell xenograft on athymic mouse].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101201

• Dose-dependent hepatoprotective effect of emodin against acetaminophen-induced acute damage in rats.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20101101

• Synergistic effect of emodin in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus.

  Pharmaceutical biology 20101101

• [Protective effects of emodin on intestinal lesion in rat model with acute necrotizing pancreatitis].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20101101

• Influence of carbon source on growth and mycotoxin production by isolates of Pyrenophora tritici-repentis from wheat.

  Canadian journal of microbiology 20101001

• In vitro & in vivo assessment of a herbal formula used topically for bone fracture treatment.

  Journal of ethnopharmacology 20100915

• Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice.

  British journal of pharmacology 20100901

• Inhibition of ATP-induced macrophage death by emodin via antagonizing P2X7 receptor.

  European journal of pharmacology 20100825

• Neuroprotective effects of emodin in rat cortical neurons against beta-amyloid-induced neurotoxicity.

  Brain research 20100806

• Emodin enhances cisplatin-induced cytotoxicity via down-regulation of ERCC1 and inactivation of ERK1/2.

  Lung cancer (Amsterdam, Netherlands) 20100801

• Apoptosis induced by emodin is associated with alterations of intracellular acidification and reactive oxygen species in EC-109 cells.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20100801

• Synthesis and biological evaluation of cytotoxic activity of novel anthracene L-rhamnopyranosides.

  Bioorganic & medicinal chemistry 20100715

• Physcion, a natural anthraquinone derivative, enhances the gene expression of leaf-specific thionin of barley against Blumeria graminis.

  Pest management science 20100701

• [Studies on the chemical constituents of radix Boehmeriae].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100701

• [Neuroprotective effects of emodin on primary rat cortical neurons apoptosis induced by hydrogen peroxide].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100701

• Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis.

  World journal of gastroenterology 20100628

• Qualitative and quantitative analysis of anthraquinone derivatives in rhizomes of tissue culture-raised Rheum emodi Wall. plants.

  Journal of plant physiology 20100615

• 4-Aminoethylamino-emodin--a novel potent inhibitor of GSK-3beta--acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin.

  Journal of cellular and molecular medicine 20100601

• Protective effects of emodin combined with danshensu on experimental severe acute pancreatitis.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20100601

• Alaternin attenuates delayed neuronal cell death induced by transient cerebral hypoperfusion in mice.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100601

• 5alpha-reductase inhibitory components as antiandrogens from herbal medicine.

  Journal of acupuncture and meridian studies 20100601

• Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells through the inhibition of gene expression of matrix metalloproteinase-9.

  International journal of oncology 20100501

• Synthesis of cytotoxic and antioxidant Schiff's base analogs of aloin.

  Journal of Asian natural products research 20100501

• A new bianthracene C-arabinopyranoside from Senna septemtrionalis.

  Natural product communications 20100501

• Pharmacokinetic comparison in rats of six bioactive compounds between Da-Cheng-Qi decoction and its parent herbal medicines.

  Natural product communications 20100501

• Emodin enhances sensitivity of gallbladder cancer cells to platinum drugs via glutathion depletion and MRP1 downregulation.

  Biochemical pharmacology 20100415

• Physcion-8-O-beta-D-glucopyranoside enhances the commitment of mouse mesenchymal progenitors into osteoblasts and their differentiation: Possible involvement of signaling pathways to activate BMP gene expression.

  Journal of cellular biochemistry 20100415

• A rapid HPLC/ESI-MS/MS method for quantitative analysis of isovalerylshikonin in rat plasma.

  Biomedical chromatography : BMC 20100401

• Anti-diabetic effects of emodin involved in the activation of PPARgamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice.

  Fitoterapia 20100401

• Structural basis for decreased affinity of Emodin binding to Val66-mutated human CK2 alpha as determined by molecular dynamics.

  Journal of molecular modeling 20100401

• A FRET-based microplate assay for human protein kinase CK2, a target in neoplastic disease.

  Journal of enzyme inhibition and medicinal chemistry 20100401

• Differences in pharmacokinetics and ex vivo antioxidant activity following intravenous and oral administrations of emodin to rats.

  Journal of pharmaceutical sciences 20100401

• Role of Rad51 down-regulation and extracellular signal-regulated kinases 1 and 2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small-cell lung cancer cells.

  Molecular pharmacology 20100401

• [Effect of emodin on P-gp expression in intrahepatic cholestatic rats].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100401

• [Studies on the chemical constituents of Kalimeris indica].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100401

• [Liposomal encapsulation of free anthraquinones in rhizoma et radix rhei and its quality control].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100401

• Mixed hemimicelles SPE based on CTAB-coated Fe3O4/SiO2 NPs for the determination of herbal bioactive constituents from biological samples.

  Talanta 20100315

• Biotransformation of paeonol and emodin by transgenic crown galls of Panax quinquefolium.

  Applied biochemistry and biotechnology 20100301

• Bioactivity-guided separation of anti-acidogenic substances against Streptococcus mutans UA 159 from Polygonum cuspidatum.

  Oral diseases 20100301

• Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.

  Anticancer research 20100301

• Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells.

  Biochemical pharmacology 20100215

• Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase.

  Bioorganic & medicinal chemistry 20100215

• Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo.

  European journal of pharmacology 20100210

• Protein kinase inhibitors emodin and dichloro-ribofuranosylbenzimidazole modulate the cellular accumulation and cytotoxicity of cisplatin in a schedule-dependent manner.

  Cancer chemotherapy and pharmacology 20100201

• Screening of Kit inhibitors: suppression of Kit signaling and melanogenesis by emodin.

  Phytotherapy research : PTR 20100201

• Crystal structure of Hyp-1, a St. John's wort protein implicated in the biosynthesis of hypericin.

  Journal of structural biology 20100201

• Docking and 3D-QSAR studies of 7-hydroxycoumarin derivatives as CK2 inhibitors.

  European journal of medicinal chemistry 20100101

• Comparison of three different extraction methods and HPLC determination of the anthraquinones aloe-emodine, emodine, rheine, chrysophanol and physcione in the bark of Rhamnus alpinus L. (Rhamnaceae).

  Phytochemical analysis : PCA 20100101

• Factors influencing the production of stilbenes by the knotweed, Reynoutria x bohemica.

  BMC plant biology 20100101

• A CE-based assay for human protein kinase CK2 activity measurement and inhibitor screening.

  Electrophoresis 20100101

• Emodin and rhein inhibit LIGHT-induced monocytes migration by blocking of ROS production.

  Vascular pharmacology 20100101

• The correlation between bioactive components of Fallopia multiflora root and environmental factors.

  The American journal of Chinese medicine 20100101

• Emodin down-regulates expression of TRPV1 mRNA and its function in DRG neurons in vitro.

  The American journal of Chinese medicine 20100101

• Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling.

  BMC genomics 20100101

• Inhibitory effect of emodin and Astragalus polysaccharide on the replication of HBV.

  World journal of gastroenterology 20091207

• [Effects of emodin on cell apoptosis of intestinal mucosa and serum leptin in rats with severe acute pancreatitis].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20091201

• [Studies on the chemical constituents of Rumex crispus].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20091201

• Emodin induces a reactive oxygen species-dependent and ATM-p53-Bax mediated cytotoxicity in lung cancer cells.

  European journal of pharmacology 20091125

• Characterization of emodin metabolites in Raji cells by LC-APCI-MS/MS.

  Bioorganic & medicinal chemistry 20091101

• Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation.

  World journal of gastroenterology 20091014

• Validation of a new yeast-based reporter assay consisting of human estrogen receptors alpha/beta and coactivator SRC-1: application for detection of estrogenic activity in environmental samples.

  Environmental toxicology 20091001

• In vitro anti-fibrotic activities of herbal compounds and herbs.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20091001

• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

  Nature chemical biology 20091001

• Light-independent metabolomics of endophytic Thielavia subthermophila provides insight into microbial hypericin biosynthesis.

  Journal of natural products 20091001

• Aggregation of antitumoral drug emodin on Ag nanoparticles: SEF, SERS and fluorescence lifetime experiments.

  Physical chemistry chemical physics : PCCP 20091001

• Emodin ameliorates high-glucose induced mesangial p38 over-activation and hypocontractility via activation of PPARgamma.

  Experimental & molecular medicine 20090930

• Emodin enhances gefitinib-induced cytotoxicity via Rad51 downregulation and ERK1/2 inactivation.

  Experimental cell research 20090910

• Induction of defence mechanisms in grapevine leaves by emodin- and anthraquinone-rich plant extracts and their conferred resistance to downy mildew.

  Plant physiology and biochemistry : PPB 20090901

• Emodin inhibits voltage-dependent potassium current in guinea pig gallbladder smooth muscle.

  Basic & clinical pharmacology & toxicology 20090901

• Inhibition of HIV-1 ribonuclease H activity by novel frangula-emodine derivatives.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20090901

• Emodin has cytotoxic and protective effects in rat C6 glioma cells: roles of Mdr1a and nuclear factor kappaB in cell survival.

  The Journal of pharmacology and experimental therapeutics 20090901

• Simultaneous determination of seven components in Qibaomeiran pill by HPLC-DAD.

  Journal of chromatographic science 20090901

• Ultraviolet light absorption of an ophthalmic formulation with Aloe extracts.

  Natural product communications 20090901

• Study on the anthraquinones separated from the cultivation of Trichoderma harzianum strain Th-R16 and their biological activity.

  Journal of agricultural and food chemistry 20090826

• Emodin suppresses cell proliferation and fibronectin expression via p38MAPK pathway in rat mesangial cells cultured under high glucose.

  Molecular and cellular endocrinology 20090813

• Targeting CpG DNA to screen and isolate anti-sepsis fraction and monomers from traditional Chinese herbs using affinity biosensor technology.

  International immunopharmacology 20090801

• Emodin augments calcium activated chloride channel in colonic smooth muscle cells by Gi/Go protein.

  European journal of pharmacology 20090801

• In vivo pharmacokinetics comparisons of icariin, emodin and psoralen from gan-kang granules and extracts of herba Epimedii, Nepal dock root, Ficus hirta yahl.

  Journal of ethnopharmacology 20090730

• Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2.

  The Biochemical journal 20090715

• The comparative toxicity to soil invertebrates of natural chemicals and their synthetic analogues.

  Chemosphere 20090701

• Chromatin-level regulation of biosynthetic gene clusters.

  Nature chemical biology 20090701

• Natural anthraquinone derivatives from a marine mangrove plant-derived endophytic fungus Eurotium rubrum: structural elucidation and DPPH radical scavenging activity.

  Journal of microbiology and biotechnology 20090701

• Positive correlations between hypericin and putative precursors detected in the quantitative secondary metabolite spectrum of Hypericum.

  Phytochemistry 20090701

• [Study on the chemical constituents of Uvaria microcarpa].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090701

• High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.

  Journal of medicinal chemistry 20090625

• Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid.

  Bioorganic & medicinal chemistry letters 20090601

• Potentiation of the effect of gemcitabine by emodin in pancreatic cancer is associated with survivin inhibition.

  Biochemical pharmacology 20090601

• [Studies on the chemical constituents of the leaves of Polygonum multiflorum].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090601

• [Simultaneous determination of anthraquinones in Liuwei'anxiao capsules by HPLC].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090601

• Bioassay-guided separation of citreorosein and other oestrogenic compounds from Polygonum cuspidatum.

  Phytotherapy research : PTR 20090501

• [Effect and mechanism of emodin on cholestatic hepatitis].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20090501

• Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages.

  Bioscience, biotechnology, and biochemistry 20090423

• Resorufin: a lead for a new protein kinase CK2 inhibitor.

  Anti-cancer drugs 20090401

• Emodin and baicalein inhibit pancreatic stromal derived factor-1 expression in rats with acute pancreatitis.

  Hepatobiliary & pancreatic diseases international : HBPD INT 20090401

• [Chemical study on petroleum ether portion of Sarcandra hainanensis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090401

• [Therapeutic effects of emodin on acute cholestatic hepatitis and mechanism thereof: experiment with rats].

  Zhonghua yi xue za zhi 20090317

• One single standard substance for the determination of multiple anthraquinone derivatives in rhubarb using high-performance liquid chromatography-diode array detection.

  Journal of chromatography. A 20090313

• Emodin reverses CCl induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural changes: The in vivo evidence.

  Hepatology research : the official journal of the Japan Society of Hepatology 20090301

• Quantitative HPLC determination and extraction of anthraquinones in Senna alata leaves.

  Journal of chromatographic science 20090301

• [Study on the optimal extracion craft of Xiaochuang gel by central composite design-response surface methodology].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090301

• Up-regulation of Toll-like receptor 4 was suppressed by emodin and baicalin in the setting of acute pancreatitis.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20090201

• Inhibitory effect of emodin on bleomycin-induced pulmonary fibrosis in mice.

  Clinical and experimental pharmacology & physiology 20090201

• Hypoglycaemic and hypolipidaemic effects of emodin and its effect on L-type calcium channels in dyslipidaemic-diabetic rats.

  Clinical and experimental pharmacology & physiology 20090101

• Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways.

  Anticancer research 20090101

• Emodin targets the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization.

  BMC microbiology 20090101

• Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53.

  Cancer cell international 20090101

• Simple and reliable methods for the determination of sixteen marker components for quality control of Daochi pill by HPLC coupled with diode array detection.

  Phytochemical analysis : PCA 20090101

• Chinese medicines as a resource for liver fibrosis treatment.

  Chinese medicine 20090101

• Is senna laxative use associated to cathartic colon, genotoxicity, or carcinogenicity?

  Journal of toxicology 20090101

• The toxicity of aconitine, emodin on ICC cell and the antagonist effect of the compatibility.

  European journal of drug metabolism and pharmacokinetics 20090101

• Influence of food polyphenols on aryl hydrocarbon receptor-signaling pathway estimated by in vitro bioassay.

  Phytochemistry 20081201

• Microwave-assisted aqueous two-phase extraction of piceid, resveratrol and emodin from Polygonum cuspidatum by ethanol/ammonium sulphate systems.

  Biotechnology letters 20081201

• Interactions of mitoxantrone with duplex and triplex DNA studied by electrospray ionization mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20081201

• A new chalcone glycoside from Rhamnus nipalensis.

  Natural product research 20081201

• Structural elucidation of in vitro metabolites of emodin by liquid chromatography-tandem mass spectrometry.

  Biomedical chromatography : BMC 20081101

• Emodin increases Ca(2+) influx through L-type Ca(2+) channel in guinea pig gallbladder smooth muscle.

  European journal of pharmacology 20081024

• Participation of cathepsin B in emodin-induced apoptosis in HK-2 Cells.

  Toxicology letters 20081001

• Emodin is a novel alkaline nuclease inhibitor that suppresses herpes simplex virus type 1 yields in cell cultures.

  British journal of pharmacology 20080901

• Selective on-line extraction of trans-resveratrol and emodin from Polygonum cuspidatum using molecularly imprinted polymer.

  Journal of chromatographic science 20080901

• [Studies on the chemical constituents of Rabdosia rubescens].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080901

• Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway.

  European journal of pharmacology 20080820

• [Studies on chemical constituents from rattan of Polygonum multiflorum].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080801

• Rapid simultaneous quantification of five active constituents in rat plasma by high-performance liquid chromatography/tandem mass spectrometry after oral administration of Da-Cheng-Qi decoction.

  Journal of pharmaceutical and biomedical analysis 20080715

• Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives.

  Bioorganic & medicinal chemistry letters 20080715

• Study of vacuum microwave-assisted extraction of polyphenolic compounds and pigment from Chinese herbs.

  Journal of chromatography. A 20080711

• [Study on the chemical constituents of Rhizoma Cyperi].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080701

• Protective effects of emodin and astragalus polysaccharides on chronic hepatic injury in rats.

  Chinese medical journal 20080605

• Tolerance of the lichen Xanthoria parietina (L.) Th. Fr. to metal stress.

  Ecotoxicology and environmental safety 20080601

• Study of interactions of anthraquinones with DNA using ethidium bromide as a fluorescence probe.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080601

• Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones.

  European journal of medicinal chemistry 20080601

• Anti-proliferative effects of estrogen receptor-modulating compounds isolated from Rheum palmatum.

  Archives of pharmacal research 20080601

• Emodin-induced apoptosis in human breast cancer BCap-37 cells through the mitochondrial signaling pathway.

  Archives of pharmacal research 20080601

• Emodin azide methyl anthraquinone derivative triggers mitochondrial-dependent cell apoptosis involving in caspase-8-mediated Bid cleavage.

  Molecular cancer therapeutics 20080601

• Inhibition of casein kinase 2 enhances the death ligand- and natural kiler cell-induced hepatocellular carcinoma cell death.

  Clinical and experimental immunology 20080501

• Emodin accelerates osteoblast differentiation through phosphatidylinositol 3-kinase activation and bone morphogenetic protein-2 gene expression.

  International immunopharmacology 20080501

• Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets.

  Mini reviews in medicinal chemistry 20080501

• Emodin promotes atherosclerotic plaque stability in fat-fed apolipoprotein E-deficient mice.

  The Tohoku journal of experimental medicine 20080501

• [Studies on chemical constituents and volatile oil of Xiaochengqi decoction].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501

• Pest-managing activities of plant extracts and anthraquinones from Cassia nigricans from Burkina Faso.

  Bioresource technology 20080401

• A new spiroketal from Aspergillus terreus, an endophytic fungus in Opuntia ficusindica Mill.

  Journal of basic microbiology 20080401

• The effect of emodin on VEGF receptors in human colon cancer cells.

  Cancer biotherapy & radiopharmaceuticals 20080401

• [Emodin induces apoptosis of cancer cells and inhibits retinoid X receptor transcriptional activity].

  Yao xue xue bao = Acta pharmaceutica Sinica 20080401

• The catalytic subunit of human protein kinase CK2 structurally deviates from its maize homologue in complex with the nucleotide competitive inhibitor emodin.

  Journal of molecular biology 20080314

• Aloin induces apoptosis in Jurkat cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20080301

• Simultaneous determination by UPLC-ESI-MS of scoparone, capillarisin, rhein, and emodin in rat urine after oral administration of Yin Chen Hao Tang preparation.

  Journal of separation science 20080301

• [Theoretical and experimental studies on solubility parameters of multiple components for traditional Chinese materia medica with HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080301

• Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase.

  Biochemistry 20080219

• Antiplasmodial compounds from Cassia siamea stem bark extract.

  Phytotherapy research : PTR 20080201

• Inhibitory effects of emodin on the proliferation of cultured rat vascular smooth muscle cell-induced by angiotensin II.

  Phytotherapy research : PTR 20080201

• An endophytic fungus from Hypericum perforatum that produces hypericin.

  Journal of natural products 20080201

• [A new qualitative and quantitative analytical method of chromatographic fingerprints: total quantum statistical moment].

  Yao xue xue bao = Acta pharmaceutica Sinica 20080201

• [The studies on the Ku Huang granula technology].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080201

• Studies of interaction of emodin and DNA in the presence of ethidium bromide by spectroscopic method.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080101

• Optimization and validation of a chromatographic method for the simultaneous quantification of six bioactive compounds in Rhizoma et Radix Polygoni Cuspidati.

  The Journal of pharmacy and pharmacology 20080101

• Emodin-induced generation of reactive oxygen species inhibits RhoA activation to sensitize gastric carcinoma cells to anoikis.

  Neoplasia (New York, N.Y.) 20080101

• Topical anti-inflammatory activity of Polygonum cuspidatum extract in the TPA model of mouse ear inflammation.

  Journal of inflammation (London, England) 20080101

• The anthraquinone derivative Emodin ameliorates neurobehavioral deficits of a rodent model for schizophrenia.

  Journal of neural transmission (Vienna, Austria : 1996) 20080101

• Emodin upregulates urokinase plasminogen activator, plasminogen activator inhibitor-1 and promotes wound healing in human fibroblasts.

  Vascular pharmacology 20080101

• [Inhibitory effects of emodin on proliferation of rat vascular smooth muscle cell induced by angiotensin II].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080101

• Feasibility evaluation of emodin (rhubarb extract) as an inhibitor of pancreatic cancer cell proliferation in vitro.

  JPEN. Journal of parenteral and enteral nutrition 20080101

• An experimental study of emodin assisted early enteral nutrition for the treatment of severe acute pancreatitis.

  Hepato-gastroenterology 20080101

• Inhibitory effect of schisandrin B on gastric cancer cells in vitro.

  World journal of gastroenterology 20071228

• [Comparison of content of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside and anthraquinon in different ploidy Radix Polygoni Multiflori].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071201

• Involvement of endogenous prostaglandin in emodin-evoked rat colonic anion secretion.

  Biological & pharmaceutical bulletin 20071101

• [Emodin induces leukemic HL-60 cells apoptosis probably by inhibiting Akt signal pathway].

  Yao xue xue bao = Acta pharmaceutica Sinica 20071101

• In situ synthesis of molecularly imprinted polymers on glass microspheres in a column.

  Analytical and bioanalytical chemistry 20071001

• A new isocoumarin from Hypericum annulatum.

  Natural product research 20071001

• Effect of vehicles on topical application of aloe vera and arnica montana components.

  Drug delivery 20071001

• [Study on correlation of soil nutrients and content of active constituents in root of Rumex gmelini].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071001

• Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent.

  Medicinal research reviews 20070901

• Spectroscopic studies of DNA binding modes of cation-substituted anthrapyrazoles derived from emodin.

  European journal of medicinal chemistry 20070901

• Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells.

  Carcinogenesis 20070901

• Quantitation assay for absorption and first-pass metabolism of emodin in isolated rat small intestine using liquid chromatography-tandem mass spectrometry.

  Biological & pharmaceutical bulletin 20070901

• Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin.

  Current biology : CB 20070821

• Silk fibroin mediated delivery of liposomal emodin to breast cancer cells.

  International journal of pharmaceutics 20070816

• Aloe emodin inhibits the cytotoxic action of tumor necrosis factor.

  European journal of pharmacology 20070730

• Ameliorating effect of emodin, a constitute of Polygonatum multiflorum, on cycloheximide-induced impairment of memory consolidation in rats.

  Journal of ethnopharmacology 20070725

• Emodin, an anthraquinone derivative from Rheum officinale Baill, enhances cutaneous wound healing in rats.

  European journal of pharmacology 20070719

• Simultaneous determination and pharmacokinetic studies of aloe emodin and chrysophanol in rats after oral administration of Da-Cheng-Qi decoction by high-performance liquid chromatography.

  Biomedical chromatography : BMC 20070701

• Cellular absorption of anthraquinones emodin and chrysophanol in human intestinal Caco-2 cells.

  Bioscience, biotechnology, and biochemistry 20070701

• Emodin suppresses interleukin-1beta induced mesangial cells proliferation and extracellular matrix production via inhibiting P38 MAPK.

  Life sciences 20070606

• Apoptosis-inducing activity of new pyrazole emodin derivatives in human hepatocellular carcinoma HepG2 cells.

  Biological & pharmaceutical bulletin 20070601

• [Application of macroporous resin in purification for effective part from Polygonum cuspidatum].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070601

• [Advance of study on apoptosis inducer of several types of natural drug].

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20070601

• Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb.

  Natural product research 20070520

• Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction.

  Antiviral research 20070501

• Synergistic interaction of physcion and chrysophanol on plant powdery mildew.

  Pest management science 20070501

• Chemical constituents of cape aloe and their synergistic growth-inhibiting effect on Ehrlich ascites tumor cells.

  Bioscience, biotechnology, and biochemistry 20070501

• Emodin induces growth arrest and death of human vascular smooth muscle cells through reactive oxygen species and p53.

  Journal of cardiovascular pharmacology 20070501

• Aloe-emodin metabolites protected N-methyl-d-aspartate-treated retinal ganglion cells by Cu-Zn superoxide dismutase.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070401

• [Comparative study on in vitro drug-release between Tuizhang ophthalmic gel and Tuizhang oculentum].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070401

• Simultaneous determination of anthraquinones in rhubarb by high-performance liquid chromatography and capillary electrophoresis.

  Journal of chromatography. A 20070323

• Emodin induces apoptosis through caspase 3-dependent pathway in HK-2 cells.

  Toxicology 20070307

• Identification of kaempferol as an inhibitor of cigarette smoke-induced activation of the aryl hydrocarbon receptor and cell transformation.

  Carcinogenesis 20070301

• Emodin and DHA potently increase arsenic trioxide interferon-alpha-induced cell death of HTLV-I-transformed cells by generation of reactive oxygen species and inhibition of Akt and AP-1.

  Blood 20070215

• Emodin with PPARgamma ligand-binding activity promotes adipocyte differentiation and increases glucose uptake in 3T3-Ll cells.

  Biochemical and biophysical research communications 20070209

• Inhibition of protein kinase CK2 leads to a modulation of androgen receptor dependent transcription in prostate cancer cells.

  The Prostate 20070201

• Alterations in secondary metabolism of aposymbiotically grown mycobionts of Xanthoria elegans and cultured resynthesis stages.

  Plant physiology and biochemistry : PPB 20070201

• Photo-irradiation of Aloe vera by UVA--formation of free radicals, singlet oxygen, superoxide, and induction of lipid peroxidation.

  Toxicology letters 20070130

• Effect of emodin on pancreatic fibrosis in rats.

  World journal of gastroenterology 20070121

• Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action.

  The international journal of biochemistry & cell biology 20070101

• Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin.

  Cancer biology & therapy 20070101

• Determination of the anthraquinones aloe-emodin and aloin-A by liquid chromatography with mass spectrometric and diode array detection.

  Journal of AOAC International 20070101

• Preparative isolation and purification of hydroxyanthraquinones from Rheum tanguticum Maxim. on normal phase silica gel: using a Flash Master Personal system.

  Preparative biochemistry & biotechnology 20070101

• Inhibition of human cytochrome p450 1b1 further clarifies its role in the activation of dibenzo[a,l]pyrene in cells in culture.

  Journal of biochemical and molecular toxicology 20070101

• Lichen secondary metabolites from the cultured lichen mycobionts of Teloschistes chrysophthalmus and Ramalina celastri and their antiviral activities.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101

• The effect of emodin-assisted early enteral nutrition on severe acute pancreatitis and secondary hepatic injury.

  Mediators of inflammation 20070101

• Anthraquinone derivative emodin inhibits tumor-associated angiogenesis through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation.

  European journal of pharmacology 20061228

• Inhibition of phosphorylation of p38 MAPK involved in the protection of nephropathy by emodin in diabetic rats.

  European journal of pharmacology 20061228

• Evaluation of the anti-angiogenic effect of aloe-emodin.

  Cellular and molecular life sciences : CMLS 20061201

• Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1).

  Life sciences 20061125

• [Effect of preparation on the major chemical constituents of Polygonum multiflorum].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20061001

• [Effect of emodin on pancreatic fibrosis: experiment with rats].

  Zhonghua yi xue za zhi 20060926

• Synthesis, DNA binding and cytotoxicity of new pyrazole emodin derivatives.

  European journal of medicinal chemistry 20060901

• Inhibition of the replication of hepatitis B virus in vitro by emodin.

  Medical science monitor : international medical journal of experimental and clinical research 20060901

• Supercritical CO2 extraction of emodin and physcion from Polygonum cuspidatum and subsequent isolation by semipreparative chromatography.

  Journal of separation science 20060901

• [Induction of hairy roots and anthraquinone production in Rheum palmatum].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060901

• Effects of pharmacological preconditioning by emodin/oleanolic acid treatment and/or ischemic preconditioning on mitochondrial antioxidant components as well as the susceptibility to ischemia-reperfusion injury in rat hearts.

  Molecular and cellular biochemistry 20060801

• Aloe-emodin induced DNA damage through generation of reactive oxygen species in human lung carcinoma cells.

  Cancer letters 20060728

• [Effect of emodin on NO-cGMP signal pathway in rat vascular endothelium in vitro].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20060701

• Emodin inhibits vascular endothelial growth factor-A-induced angiogenesis by blocking receptor-2 (KDR/Flk-1) phosphorylation.

  International journal of cancer 20060601

• Emodin inhibits tumor cell adhesion through disruption of the membrane lipid Raft-associated integrin signaling pathway.

  Cancer research 20060601

• [HPLC fingerprint of Rhizoma Polygoni Cuspidati].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060601

• [Experimental study on effects of emodin on nonalcoholic fatty liver induced by high fat diet in rats].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina.

  The American journal of pathology 20060501

• [Correlation of anti-bacterial activity with secondary metabolites content in Sargentodoxa Cuneata tables].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20060501

• [Studies on the chemical constituents in stem rind of Wikstroemia indica].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060501

• Evaluation of MTT assay for measurement of emodin-induced cytotoxicity.

  Assay and drug development technologies 20060401

• [Study on the selection of crude drugs of rhubarb dispensing granule].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060401

• Effects of emodin on Ca2+ signal transduction of smooth muscle cells in multiple organ dysfunction syndrome.

  The Journal of surgical research 20060301

• Role of exon-16-deleted HER2 in breast carcinomas.

  Endocrine-related cancer 20060301

• [Simultaneous determination of three kinds of components in sanhuang tablets by high-performance liquid chromatography].

  Yao xue xue bao = Acta pharmaceutica Sinica 20060301

• Silk-fibroin-coated liposomes for long-term and targeted drug delivery.

  International journal of nanomedicine 20060301

• Antidiabetic effects of dietary administration of Aloe arborescens Miller components on multiple low-dose streptozotocin-induced diabetes in mice: investigation on hypoglycemic action and systemic absorption dynamics of aloe components.

  Journal of ethnopharmacology 20060220

• Isolation and inhibitory activity against ERK phosphorylation of hydroxyanthraquinones from rhubarb.

  Bioorganic & medicinal chemistry letters 20060201

• [Simultaneous determination of resveratrol, emodin, chrysophanol, physcion, in root of Polygonam cuspidatum and its extract by HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060201

• [Studies on chemical constituents of hairy root of Cassia obtusifolia].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060201

• [Ultracytochemical studies of aloin in Aloe arborescens leaves].

  Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology 20060201

• Bi-directional regulation of emodin and quercetin on smooth muscle myosin of gizzard.

  FEBS letters 20060123

• Cytotoxicity of a natural anthraquinone (Aloin) against human breast cancer cell lines with and without ErbB-2: topoisomerase IIalpha coamplification.

  Cancer biology & therapy 20060101

• Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway.

  The Journal of urology 20060101

• [Preparative separation of aloin diastereoisomers by high-speed countercurrent chromatography combined with silica gel column chromatography].

  Se pu = Chinese journal of chromatography 20060101

• Aloe-emodin affects the levels of cytokines and functions of leukocytes from Sprague-Dawley rats.

  In vivo (Athens, Greece) 20060101

• Determination and locational variations in the quantity of hydroxyanthraquinones and their glycosides in rhizomes of Rheum emodi using high-performance liquid chromatography.

  Journal of chromatography. A 20051202

• Preparative isolation and purification of five compounds from the Chinese medicinal herb Polygonum cuspidatum Sieb. et Zucc by high-speed counter-current chromatography.

  Journal of chromatography. A 20051202

• Effect of inhibition of aloe-emodin on N-acetyltransferase activity and gene expression in human malignant melanoma cells (A375.S2).

  Melanoma research 20051201

• [Chemical constituents of the aerial parts of Rhamnus crenatus].

  Yao xue xue bao = Acta pharmaceutica Sinica 20051201

• Birch PR-10c interacts with several biologically important ligands.

  Phytochemistry 20051101

• Spectroscopic characterization of effective components anthraquinones in Chinese medicinal herbs binding with serum albumins.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051101

• Antimutagenicity and cytotoxicity of the constituents from the aerial parts of Rumex acetosa.

  Biological & pharmaceutical bulletin 20051101

• Effects of emodin treatment on mitochondrial ATP generation capacity and antioxidant components as well as susceptibility to ischemia-reperfusion injury in rat hearts: single versus multiple doses and gender difference.

  Life sciences 20051014

• Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds.

  Antiviral research 20051001

• Evaluation of the antibacterial activity of Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn.: isolation of emodin and physcion as active antibacterial agents.

  Phytotherapy research : PTR 20051001

• Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells.

  International journal of oncology 20050901

• Antimycobacterial agents from selected Mexican medicinal plants.

  The Journal of pharmacy and pharmacology 20050901

• [Emodin blocks voltage dependent potassium channels in rat proximal colon smooth muscle cells].

  Yao xue xue bao = Acta pharmaceutica Sinica 20050901

• Separation and determination of four active anthraquinones in Chinese herbal preparations by flow injection-capillary electrophoresis.

  Electrophoresis 20050801

• [A new isoflavone from Huoxue Yiqi Tang].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050801

• Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway.

  Biochemical pharmacology 20050715

• Effects of emodin on synaptic transmission in rat hippocampal CA1 pyramidal neurons in vitro.

  Neuropharmacology 20050701

• Gene expression alteration during redox-dependent enhancement of arsenic cytotoxicity by emodin in HeLa cells.

  Cell research 20050701

• [Studies on the chemical constituents in herb of Mentha haplocalyx].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050701

• Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin.

  Cellular and molecular life sciences : CMLS 20050601

• Aloe emodin-induced apoptosis in t-HSC/Cl-6 cells involves a mitochondria-mediated pathway.

  Basic & clinical pharmacology & toxicology 20050601

• [Study on the optimal harvesting time of Rumex gmelini by analyzing the contents of principal components].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050601

• [Influence of processing rhubarb on it's anthraquinone contents].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050601

• Effect of emodin on small intestinal peristalsis of mice and relevant mechanism.

  World journal of gastroenterology 20050528

• Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway.

  Cellular and molecular life sciences : CMLS 20050501

• Effects of emodin and baicalein on rats with severe acute pancreatitis.

  World journal of gastroenterology 20050414

• Effects of emodin on treating murine nonalcoholic fatty liver induced by high caloric laboratory chaw.

  World journal of gastroenterology 20050307

• Release of nucleophosmin from the nucleus: Involvement in aloe-emodin-induced human lung non small carcinoma cell apoptosis.

  International journal of cancer 20050301

• Anti-glioma action of aloe emodin: the role of ERK inhibition.

  Cellular and molecular life sciences : CMLS 20050301

• [Influence of process methods on contents of chemical component Radix Polygoni Multiflori].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050301

• [Study on the chemical constituents from Rumex japonicus Houtt].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050201

• Identification of potential biomarkers of genotoxicity and carcinogenicity in L5178Y mouse lymphoma cells by cDNA microarray analysis.

  Environmental and molecular mutagenesis 20050101

• DNA ploidy and S phase fraction of breast and ovarian tumor cells treated with a natural anthracycline analog (aloin).

  Cancer biology & therapy 20050101

• Influence of functional group substitutions on the carcinogenicity of anthraquinone in rats and mice: analysis of long-term bioassays by the National Cancer Institute and the National Toxicology Program.

  Journal of toxicology and environmental health. Part B, Critical reviews 20050101

• Novel curcumin- and emodin-related compounds identified by in silico 2D/3D conformer screening induce apoptosis in tumor cells.

  BMC cancer 20050101

• Analysis of the anthraquinones aloe-emodin and aloin by gas chromatography/mass spectrometry.

  International immunopharmacology 20041220

• Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells.

  International immunopharmacology 20041220

• Anthraquinones sensitize tumor cells to arsenic cytotoxicity in vitro and in vivo via reactive oxygen species-mediated dual regulation of apoptosis.

  Free radical biology & medicine 20041215

• [Effect of emodin on motility signal transduction in colonic smooth muscle cells in rats with multiple organ dysfunction syndrome].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20041201

• Synthesis and biological evaluation of new derivatives of emodin.

  Bioorganic & medicinal chemistry 20041115

• Aspergillus fumigatus CY018, an endophytic fungus in Cynodon dactylon as a versatile producer of new and bioactive metabolites.

  Journal of biotechnology 20041109

• Anti-proliferative lichen compounds with inhibitory activity on 12(S)-HETE production in human platelets.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20041101

• [Simultaneous determination of 4 anthraquinones in Kuhuang injection by RP-HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20041101

• Peroxynitrite scavenging mode of alaternin isolated from Cassia tora.

  The Journal of pharmacy and pharmacology 20041001

• The stimulant cathartic, emodin, contracts the rat isolated ileum by triggering release of endogenous acetylcholine.

  Autonomic & autacoid pharmacology 20041001

• Effect of chemopreventive agents on glutathione S-transferase P1-1 gene expression mechanisms via activating protein 1 and nuclear factor kappaB inhibition.

  Biochemical pharmacology 20040915

• Alaternin and emodin with hydroxyl radical inhibitory and/or scavenging activities and hepatoprotective activity on tacrine-induced cytotoxicity in HepG2 cells.

  Archives of pharmacal research 20040901

• [Determination of active anthraquinones in Rheum and its tea preparations by micellar electrokinetic capillary electrophoresis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040901

• [Determination of aloin content in callus of Aloe vera var. chinensis].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040901

• Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040801

• Membrane-related effects underlying the biological activity of the anthraquinones emodin and barbaloin.

  Biochemical pharmacology 20040801

• Herb medicine Inchin-ko-to (TJ-135) regulates PDGF-BB-dependent signaling pathways of hepatic stellate cells in primary culture and attenuates development of liver fibrosis induced by thioacetamide administration in rats.

  Journal of hepatology 20040801

• Six immunosuppressive features from an ascomycete, Zopfiella longicaudata, found in a screening study monitored by immunomodulatory activity.

  Chemical & pharmaceutical bulletin 20040801

• Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-kappaB.

  Biochemical pharmacology 20040715

• The lichens Xanthoria elegans and Cetraria islandica maintain a high protection against UV-B radiation in Arctic habitats.

  Oecologia 20040701

• Aloe-emodin prevents cytokine-induced tumor cell death: the inhibition of auto-toxic nitric oxide release as a potential mechanism.

  Cellular and molecular life sciences : CMLS 20040701

• [The inhibitive effects of the ethanol extract from Radix et Rhizoma Rhei on the secretion of HBsAg and HBeAg].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040601

• Signal pathways involved in emodin-induced contraction of smooth muscle cells from rat colon.

  World journal of gastroenterology 20040515

• Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.

  Journal of ethnopharmacology 20040401

• Rational elimination of Aspergillus terreus sulochrin production.

  Journal of biotechnology 20040304

• Ethanol and aloe emodin alter the p53 mutational spectrum in ultraviolet radiation-induced murine skin tumors.

  Molecular carcinogenesis 20040301

• Dicoumarol alters cellular redox state and inhibits nuclear factor kappa B to enhance arsenic trioxide-induced apoptosis.

  Acta biochimica et biophysica Sinica 20040301

• Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake.

  The Journal of biological chemistry 20040109

• Antisense blocking of BRCA1 enhances sensitivity to plumbagin but not tamoxifen in BG-1 ovarian cancer cells.

  Molecular carcinogenesis 20040101

• Emodin enhances arsenic trioxide-induced apoptosis via generation of reactive oxygen species and inhibition of survival signaling.

  Cancer research 20040101

• Evaluation of a real-time polymerase chain reaction method for the quantification of CYP1B1 gene expression in MCF-7 human breast carcinoma cells.

  Journal of pharmacological and toxicological methods 20040101

• Microbial glycosylation of four free anthraquinones by Absidia coerulea.

  Biotechnology letters 20040101

• Emodin isolated from Cassia obtusifolia (Leguminosae) seed shows larvicidal activity against three mosquito species.

  Journal of agricultural and food chemistry 20031217

• Tumor necrosis factor-alpha and troglitazone regulate plasminogen activator inhibitor type 1 production through extracellular signal-regulated kinase- and nuclear factor-kappaB-dependent pathways in cultured human umbilical vein endothelial cells.

  The Journal of pharmacology and experimental therapeutics 20031201

• Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.

  Environmental health perspectives 20031201

• Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  Biological & pharmaceutical bulletin 20031201

• Radical-scavenging effects of Aloe arborescens Miller on prevention of pancreatic islet B-cell destruction in rats.

  Journal of ethnopharmacology 20031101

• [Therapeutic effect of qingyi decoction and tetrandrine in treating severe acute pancreatitis in miniature pigs and serum drug level determination].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20031101

• [Relationship between antibacterial activity of aloe and its anthaquinone compounds].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031101

• High-performance liquid chromatographic assay for the determination of Aloe Emodin in mouse plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031025

• Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin.

  International journal of cancer 20031010

• Micropropagation of Polygonum multiflorum THUNB and quantitative analysis of the anthraquinones emodin and physcion formed in in vitro propagated shoots and plants.

  Biological & pharmaceutical bulletin 20031001

• [Development of aloin cells and accumulation of anthraquinone in aloe leaf].

  Shi yan sheng wu xue bao 20031001

• [Phenolic compounds isolated from rhizoma of Aster tataricus].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031001

• Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA).

  The Biochemical journal 20030915

• Aloe-emodin inhibited N-acetylation and DNA adduct of 2-aminofluorene and arylamine N-acetyltransferase gene expression in mouse leukemia L 1210 cells.

  Leukemia research 20030901

• Contractile effects and intracellular Ca2+ signalling induced by emodin in circular smooth muscle cells of rat colon.

  World journal of gastroenterology 20030815

• Cynodontin: a fungal metabolite with antifungal properties.

  Journal of agricultural and food chemistry 20030813

• Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell.

  International journal of cancer 20030810

• Emodin ameliorates glucose-induced matrix synthesis in human peritoneal mesothelial cells.

  Kidney international 20030801

• Sulfemodin 8-O-beta-D-glucoside, a new sulfated anthraquinone glycoside, and antioxidant phenolic compounds from Rheum emodi.

  Journal of natural products 20030801

• [Advances in the study on molecular mechanism of diabetic nephropathy treated with Rheum officinale].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030801

• Emodin induces apoptosis of human cervical cancer cells through poly(ADP-ribose) polymerase cleavage and activation of caspase-9.

  European journal of pharmacology 20030725

• [Studies on the chemical constituents of Dendrobium fimbriatum].

  Yao xue xue bao = Acta pharmaceutica Sinica 20030701

• Neuraminidase inhibitors from Reynoutria elliptica.

  Archives of pharmacal research 20030501

• [Studies on the extraction of ingredients from Chinese traditional medicine with CO2 supercritical fluid].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030501

• Capillary electrophoresis for simultaneous determination of emodin, chrysophanol, and their 8-beta-D-glucosides.

  Chemical & pharmaceutical bulletin 20030401

• [Effect of emodin and apigenin on invasion of human ovarian carcinoma HO-8910PM cells in vitro].

  Ai zheng = Aizheng = Chinese journal of cancer 20030401

• Is parietin a UV-B or a blue-light screening pigment in the lichen Xanthoria parietina?

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20030401

• Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.

  The EMBO journal 20030317

• Celecoxib acts in a cyclooxygenase-2-independent manner and in synergy with emodin to suppress rat cholangiocarcinoma growth in vitro through a mechanism involving enhanced Akt inactivation and increased activation of caspases-9 and -3.

  Molecular cancer therapeutics 20030301

• Transcriptional suppression of the HIV promoter by natural compounds.

  Antiviral research 20030301

• Determination of active components in rhubarb and study of their hydrophobicity by micellar electrokinetic chromatography.

  Bioorganic & medicinal chemistry letters 20030224

• Inhibition of protein kinase CK2 by anthraquinone-related compounds. A structural insight.

  The Journal of biological chemistry 20030117

• Inhibition of collagenase and metalloproteinases by aloins and aloe gel.

  Life sciences 20030103

• Inhibition of azoxymethane-induced DNA adduct formation by Aloe arborescens var. natalensis.

  Asian Pacific journal of cancer prevention : APJCP 20030101

• Identification of major metabolites in Aloe littoralis by high-performance liquid chromatography-nuclear magnetic resonance spectroscopy.

  Phytochemical analysis : PCA 20030101

• Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production.

  Biochemical pharmacology 20021215

• Permeation-enhancing effect of aloe-emodin anthrone on water-soluble and poorly permeable compounds in rat colonic mucosa.

  Biological & pharmaceutical bulletin 20021201

• Aloin, cinnamic acid and sophorcarpidine are potent inhibitors of tyrosinase.

  Chinese medical journal 20021201

• In vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin.

  Planta medica 20021101

• Inducible nitric oxide synthase inhibitors of Chinese herbs III. Rheum palmatum.

  Planta medica 20021001

• [Determination of six effective components in Rheum by cyclodextrin modified micellar electrokinetic chromatography].

  Yao xue xue bao = Acta pharmaceutica Sinica 20021001

• The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines.

  Life sciences 20020906

• Chemopreventive effects of emodin and cassiamin B in mouse skin carcinogenesis.

  Cancer letters 20020828

• Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis.

  Oncogene 20020808

• Mechanisms of Chinese herb emodin and somatostatin analogs on pancreatic regeneration in acute pancreatitis in rats.

  Pancreas 20020801

• Cyclooxygenase-2 and ERBB-2 in cholangiocarcinoma: potential therapeutic targets.

  Seminars in liver disease 20020801

• Induction of apoptosis in hepatocellular carcinoma cell lines by emodin.

  Japanese journal of cancer research : Gann 20020801

• Simultaneous determination of Aloe-emodin and Rhein by synchronous fluorescence spectroscopy.

  Journal of pharmaceutical and biomedical analysis 20020720

• Studies on the photostability and phototoxicity of aloe-emodin, emodin and rhein.

  Die Pharmazie 20020601

• [Contents of barbaloin-related compounds in aloe drinks and their change during storage].

  Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20020601

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Photochemistry and phototoxicity of aloe emodin.

  Photochemistry and photobiology 20020401

• Aloe emodin suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture.

  Pharmacology & toxicology 20020401

• [Studies on the chemical constituents in root of Rheum rhizastachyum].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020401

• The effect of aloe emodin on the proliferation of a new merkel carcinoma cell line.

  The American Journal of dermatopathology 20020201

• [Studies on the chemical constituents of the stems of Alyxia sinensis (I)].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020201

• [Hairy-root culture of Polygonium multiflorum Thunb. and the production of its active constituents-anthraquinones].

  Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20020101

• ErbB2 overexpression in an ovarian cancer cell line confers sensitivity to the HSP90 inhibitor geldanamycin.

  Anticancer research 20020101

• Toward the rational design of protein kinase casein kinase-2 inhibitors.

  Pharmacology & therapeutics 20020101

• Cytotoxicity of natural hydroxyanthraquinones: role of oxidative stress.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101

• Effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia CMK-7 cell line.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101

• [Study on the quantitative change of anthraquinonoids of Rhei in the preparation of dachengqi].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020101

• Discovery, total synthesis, HRV 3C-protease inhibitory activity, and structure-activity relationships of 2-methoxystypandrone and its analogues.

  Bioorganic & medicinal chemistry letters 20011217

• Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma.

  European journal of pharmacology 20011123

• Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole.

  Protein science : a publication of the Protein Society 20011101

• Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell.

  British journal of pharmacology 20011101

• Hypotensive effect of chemical constituents from Aloe barbadensis.

  Planta medica 20011101

• Hepatotoxin rubratoxin B induced the secretion of TNF-alpha, IL-8, and MCP-1 in HL60 cells.

  Biochemical and biophysical research communications 20011005

• Aloe exudate: characterization by reversed phase HPLC and headspace GC-MS.

  Journal of agricultural and food chemistry 20011001

• [Studies on the chemical constituents of Evodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang].

  Yao xue xue bao = Acta pharmaceutica Sinica 20011001

• [Studies on chemical constituents of Bletilla striata (Thunb) Reichb. f].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20011001

• Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5.

  Drug metabolism and disposition: the biological fate of chemicals 20010901

• Effects and mechanisms of emodin on cell death in human lung squamous cell carcinoma.

  British journal of pharmacology 20010901

• Cytotoxicity of Rhamnosylanthraquinones and Rhamnosylanthrones from Rhamnus nepalensis.

  Journal of natural products 20010901

• Metabolism of 1,8-dihydroxy 3-hydroxy methyl anthraquinone (aloe-emodin) isolated from the leaves of Cassia tora in albino rats.

  Phytotherapy research : PTR 20010801

• Generation of free radicals by emodic acid and its [D-Lys6]GnRH-conjugate.

  Photochemistry and photobiology 20010801

• [Effects of emodin on hepatic fibrosis in rats].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20010801

• Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity.

  Bioorganic & medicinal chemistry letters 20010723

• Autocatalytic tyrosine-phosphorylation of protein kinase CK2 alpha and alpha' subunits: implication of Tyr182.

  The Biochemical journal 20010715

• [Effect of aloe-emodin on c-myc gene expression of cultured vascular smooth muscle cells of injured artery].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010701

• Effect of aloe-emodin on expression of proliferating cell nuclear antigen of vascular smooth muscle cells in culture after arterial injury.

  Chinese medical journal 20010601

• [Study on effect of emodin on TGF beta 1 expression in pancreatic tissue of rats suffering from acute pancreatitis].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010601

• Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').

  FEBS letters 20010504

• Cytotoxic principles from Ventilago leiocarpa.

  Journal of natural products 20010501

• In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus.

  Antiviral research 20010301

• Immune reponses in human mesangial cells regulated by emodin from Polygonum hypoleucum Ohwi.

  Life sciences 20010202

• Determination of pKa values of anthraquinone compounds by capillary electrophoresis.

  Electrophoresis 20010201

• Regulation of cell proliferation, inflammatory cytokine production and calcium mobilization in primary human T lymphocytes by emodin from Polygonum hypoleucum Ohwi.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010201

• Emodin ameliorates glucose-induced morphologic abnormalities and synthesis of transforming growth factor beta1 and fibronectin by human peritoneal mesothelial cells.

  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20010101

• Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules.

  Proceedings of the National Academy of Sciences of the United States of America 19960903

• Hydroxyquinones are competitive non-peptide inhibitors of HIV-1 proteinase.

  Biochimica et biophysica acta 19951115

• Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols.

  Archives of biochemistry and biophysics 19951001

• Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates.

  Drug metabolism and disposition: the biological fate of chemicals 19940101

• Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus.

  Antiviral research 19920101

• In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives.

  Antiviral research 19910901