51857-17-1 | N-Boc-1,6-diaminohexane

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$8.00	$5.00
5g	98%	in stock	$22.00	$16.00
10g	98%	in stock	$28.00	$19.00
25g	98%	in stock	$56.00	$39.00
100g	98%	in stock	$203.00	$142.00

Description

• Catalog Number: AB46787
• Chemical Name: N-Boc-1,6-diaminohexane
• CAS Number: 51857-17-1
• Molecular Formula: C11H24N2O2
• Molecular Weight: 216.3205
• MDL Number: MFCD00671489
• SMILES: NCCCCCCNC(=O)OC(C)(C)C

Computed Properties

• Complexity: 176
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 15
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 8
• XLogP3: 1.4

Upstream Synthesis Route

N-tert-Butoxycarbonyl-1,6-hexanediamine is a versatile compound widely utilized in chemical synthesis for its ability to protect and functionalize amino groups. By incorporating this compound into reactions, chemists can selectively modify specific amino groups in a molecule while keeping others unaffected. This selective protection is crucial in complex synthesis processes where multiple reactive sites exist within a molecule. In peptide chemistry, N-tert-Butoxycarbonyl-1,6-hexanediamine plays a pivotal role in solid-phase peptide synthesis by safeguarding the N-terminal amino group of amino acids. This protection ensures that the desired peptide sequence is assembled correctly without unintended side reactions. Furthermore, the tert-butoxycarbonyl (Boc) group can be easily removed under mild conditions, making it a valuable tool in peptide synthesis.Additionally, this compound is utilized in the preparation of various pharmaceutical compounds, as well as in the synthesis of polymers and other specialty chemicals. Its application extends to the creation of complex organic molecules in medicinal chemistry and drug development.Overall, N-tert-Butoxycarbonyl-1,6-hexanediamine is a crucial reagent in chemical synthesis, allowing chemists to control and manipulate amino groups with precision, ultimately facilitating the creation of diverse and intricate molecules for various applications.

Literature

• Growth inhibition of human thyroid carcinoma and goiter cells in vitro by the isoflavone derivative 7-(O)-carboxymethyl daidzein conjugated to N-t-boc-hexylenediamine.

  Thyroid : official journal of the American Thyroid Association 20120801

• Anti-thyroid cancer properties of a novel isoflavone derivative, 7-(O)-carboxymethyl daidzein conjugated to N-t-Boc-hexylenediamine in vitro and in vivo.

  The Journal of steroid biochemistry and molecular biology 20110901

• 7-(O)-Carboxymethyl daidzein conjugated to N-t-Boc-hexylenediamine: a novel compound capable of inducing cell death in epithelial ovarian cancer stem cells.

  Cancer biology & therapy 20090901

• Novel biodegradable poly(disulfide amine)s for gene delivery with high efficiency and low cytotoxicity.

  Bioconjugate chemistry 20080301

• Synthesis and evaluation of the antiproliferative activities of derivatives of carboxyalkyl isoflavones linked to N-t-Boc-hexylenediamine.

  Journal of medicinal chemistry 20071213

• Poly(epsilon-caprolactone)-poly(oxyethylene) multiblock copolymers bearing along the chain regularly spaced pendant amino groups.

  Macromolecular bioscience 20070410