5190-68-1 | 4-Chloroquinazoline

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$9.00	$7.00
5g	98%	in stock	$35.00	$25.00
10g	98%	in stock	$60.00	$42.00
25g	98%	in stock	$145.00	$102.00

Description

• Catalog Number: AB67288
• Chemical Name: 4-Chloroquinazoline
• CAS Number: 5190-68-1
• Molecular Formula: C8H5ClN2
• Molecular Weight: 164.5917
• MDL Number: MFCD00228682
• SMILES: Clc1ncnc2c1cccc2
• NSC Number: 53480

Computed Properties

• Complexity: 140
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 2
• XLogP3: 1.9

Upstream Synthesis Route

4-Chloroquinazoline is a valuable building block in chemical synthesis due to its versatile reactivity and useful structural characteristics. This compound serves as a key intermediate in the production of pharmaceuticals, agrochemicals, and materials with various applications.In organic synthesis, 4-Chloroquinazoline can undergo a wide range of transformations, such as substitution, functional group interconversions, and coupling reactions. Its chloro substituent provides an anchor point for further modifications, allowing chemists to fine-tune the properties of the final products. This compound's unique quinazoline scaffold is often exploited for its structural diversity and biological activity in drug discovery research.In the pharmaceutical industry, 4-Chloroquinazoline has been utilized in the synthesis of potential drug candidates targeting various therapeutic areas, including oncology, infectious diseases, and central nervous system disorders. By incorporating 4-Chloroquinazoline into molecular frameworks, medicinal chemists can tailor the pharmacokinetic and pharmacodynamic profiles of novel compounds. Furthermore, this compound's presence in bioactive molecules has contributed to the development of innovative treatments and therapies.In agrochemistry, 4-Chloroquinazoline plays a crucial role in designing new pesticides, herbicides, and fungicides with enhanced efficacy and environmental safety. Its structural features enable the creation of crop protection products that exhibit targeted activity against pests and pathogens, thereby improving agricultural productivity and sustainability.Through its participation in diversified chemical reactions and its significance in the synthesis of biologically active compounds, 4-Chloroquinazoline continues to be a valuable asset in the realm of chemical synthesis, driving innovation and discovery across multiple industries.

Literature

• Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.

  Journal of medicinal chemistry 20120913

• Imaging of EGFR and EGFR tyrosine kinase overexpression in tumors by nuclear medicine modalities.

  Current pharmaceutical design 20081001

• Microwave assisted synthesis of N-arylheterocyclic substituted-4-aminoquinazoline derivatives.

  Molecules (Basel, Switzerland) 20060410