522629-08-9 | CGP-57380

Packsize	Purity	Availability	Price	Discounted Price
1mg	98+%	in stock	$23.00	$17.00
5mg	98+%	in stock	$59.00	$41.00
10mg	98+%	in stock	$87.00	$61.00
50mg	98+%	in stock	$250.00	$175.00

Description

• Catalog Number: AG19635
• Chemical Name: CGP-57380
• CAS Number: 522629-08-9
• Molecular Formula: C11H9FN6
• Molecular Weight: 244.2278
• MDL Number: MFCD03861062
• SMILES: Fc1ccc(cc1)Nc1n[nH]c2c1c(N)ncn2
• NSC Number: 741567

Computed Properties

• Complexity: 283
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 2
• XLogP3: 2.3

Literature

• Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.

  PloS one 20150101

• A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

  The Biochemical journal 20130415

• MNK1 expression increases during cellular senescence and modulates the subcellular localization of hnRNP A1.

  Experimental cell research 20120310

• Targeting Mnks for cancer therapy.

  Oncotarget 20120201

• Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

  Nature biotechnology 20111101

• Identification of new inhibitors of protein kinase R guided by statistical modeling.

  Bioorganic & medicinal chemistry letters 20110701

• MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma.

  Cancer research 20110315

• Mnk mediates integrin α6β4-dependent eIF4E phosphorylation and translation of VEGF mRNA.

  Molecular cancer research : MCR 20101201

• The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival.

  Cancer biology & therapy 20101001

• Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.

  Journal of medicinal chemistry 20100923

• Pro-inflammatory cytokine release in keratinocytes is mediated through the MAPK signal-integrating kinases.

  Experimental dermatology 20080601

• Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2.

  The Journal of biological chemistry 20080502

• MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages.

  American journal of physiology. Gastrointestinal and liver physiology 20080201

• The selectivity of protein kinase inhibitors: a further update.

  The Biochemical journal 20071215

• Loss of MNK function sensitizes fibroblasts to serum-withdrawal induced apoptosis.

  Genes to cells : devoted to molecular & cellular mechanisms 20071001

• Shiga toxin 1-induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage-like THP-1 cell line.

  Journal of leukocyte biology 20060201

• Adenovirus-induced extracellular signal-regulated kinase phosphorylation during the late phase of infection enhances viral protein levels and virus progeny.

  Cancer research 20060201

• Posttranscriptional regulation of TNFalpha expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages.

  Cytokine 20060107

• Shiga toxins activate translational regulation pathways in intestinal epithelial cells.

  Cellular signalling 20050701

• Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2).

  The Biochemical journal 20050615

• Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities.

  Cancer research 20041201

• Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells.

  Circulation research 20031212

• Phosphorylation of initiation factor 4E is resistant to SB203580 in cells expressing a drug-resistant mutant of stress-activated protein kinase 2a/p38.

  Cellular signalling 20030801

• Phosphorylation of eukaryotic initiation factor (eIF) 4E is not required for de novo protein synthesis following recovery from hypertonic stress in human kidney cells.

  The Journal of biological chemistry 20020906

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419