-
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Bioorganic & medicinal chemistry 20121115
-
Dose-response relationships of FMISO between trace dose and various macro-doses in rat by ultra-performance liquid chromatography with mass spectrometry and radioactivity analysis.
Journal of pharmaceutical and biomedical analysis 20121101
-
On the structural modification of 2-nitroimidazole-(99m)Tc(CO)(3) complex, a hypoxia marker, for improving in vivo pharmacokinetics.
Nuclear medicine and biology 20121101
-
In vitro and in vivo evaluation of [(18)F]F-GAZ, a novel oxygen-mimetic azomycin-glucose conjugate, for imaging hypoxic tumor.
Cancer biotherapy & radiopharmaceuticals 20121001
-
Synthesis and characterization of a hypoxia-sensitive MRI probe.
Chemistry (Weinheim an der Bergstrasse, Germany) 20120727
-
Synthetic control of framework zinc purinate crystallisation and properties of a large pore, decorated, mixed-linker RHO-type ZIF.
Chemical communications (Cambridge, England) 20120707
-
Syntheses of 2-nitroimidazole derivatives conjugated with 1,4,7-triazacyclononane-N,N'-diacetic acid labeled with F-18 using an aluminum complex method for hypoxia imaging.
Journal of medicinal chemistry 20120412
-
Development of hypoxia enhanced 111In-labeled Bombesin conjugates: design, synthesis, and in vitro evaluation in PC-3 human prostate cancer.
Bioconjugate chemistry 20120321
-
2-Nitroimidazole-tricarbocyanine conjugate as a near-infrared fluorescent probe for in vivo imaging of tumor hypoxia.
Bioconjugate chemistry 20120321
-
The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxia.
Clinical cancer research : an official journal of the American Association for Cancer Research 20120315
-
Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302.
Molecular cancer therapeutics 20120301
-
Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 20120201
-
Effect of a second nitroimidazole redox centre on the accumulation of a hypoxia marker: synthesis and in vitro evaluation of 99mTc-labeled bisnitroimidazole propylene amine oxime complexes.
Bioorganic & medicinal chemistry letters 20120101
-
Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia.
PloS one 20120101
-
Targeting tumor perfusion and oxygenation to improve the outcome of anticancer therapy.
Frontiers in pharmacology 20120101
-
Stroma targeting nuclear imaging and radiopharmaceuticals.
International journal of molecular imaging 20120101
-
Development of (99m)Tc-N4-NIM for molecular imaging of tumor hypoxia.
Journal of biomedicine & biotechnology 20120101
-
Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents.
Journal of medicinal chemistry 20111208
-
Imaging hypoxia in gliomas.
The British journal of radiology 20111201
-
Preparation of nucleosides derived from 2-nitroimidazole and D-arabinose, D-ribose, and D-galactose by the Vorbrüggen method and their conversion to potential precursors for tracers to image hypoxia.
The Journal of organic chemistry 20111021
-
Nitroimidazole radiopharmaceuticals in hypoxia: part II cytotoxicity and radiosensitization applications.
Current radiopharmaceuticals 20111001
-
Immunohistochemical assessment of intrinsic and extrinsic markers of hypoxia in reproductive tissue: differential expression of HIF1α and HIF2α in rat oviduct and endometrium.
Journal of molecular histology 20110801
-
Synthesis and evaluation of two novel 2-nitroimidazole derivatives as potential PET radioligands for tumor imaging.
Nuclear medicine and biology 20110501
-
Indirect competitive enzyme-linked immuno-sorbent assay (ELISA) for nitroimidazoles in food products.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20110501
-
Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer.
Cancer research 20110415
-
The biological characterization of (99m)Tc-BnAO-NI as a SPECT probe for imaging hypoxia in a sarcoma-bearing mouse model.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20110401
-
Catabolic pathway for 2-nitroimidazole involves a novel nitrohydrolase that also confers drug resistance.
Environmental microbiology 20110401
-
Radiosynthesis of the tumor hypoxia marker [18F]TFMISO via O-[18F]trifluoroethylation reveals a striking difference between trifluoroethyl tosylate and iodide in regiochemical reactivity toward oxygen nucleophiles.
Bioorganic & medicinal chemistry 20110401
-
Nitroimidazole derivative-induced fixed drug eruptions: Not so uncommon.
Indian journal of pharmacology 20110401
-
2-Chloro-N-[(4-chloro-phen-yl)(phen-yl)meth-yl]-N-[2-(4-nitro-1H-imidazol-1-yl)eth-yl]ethanamine.
Acta crystallographica. Section E, Structure reports online 20110201
-
Location of intra- and extracellular M. tuberculosis populations in lungs of mice and guinea pigs during disease progression and after drug treatment.
PloS one 20110101
-
Oxygen, a Key Factor Regulating Cell Behavior during Neurogenesis and Cerebral Diseases.
Frontiers in molecular neuroscience 20110101
-
Ionizing radiation and inhibition of angiogenesis in a spontaneous mammary carcinoma and in a syngenic heterotopic allograft tumor model: a comparative study.
Radiation oncology (London, England) 20110101
-
Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104.
PloS one 20110101
-
Significant impact of different oxygen breathing conditions on noninvasive in vivo tumor-hypoxia imaging using [¹⁸F]-fluoro-azomycinarabino-furanoside ([¹⁸F]FAZA).
Radiation oncology (London, England) 20110101
-
Targeting hypoxic tumour cells to overcome metastasis.
BMC cancer 20110101
-
In vivo T cell activation in lymphoid tissues is inhibited in the oxygen-poor microenvironment.
Frontiers in immunology 20110101
-
Biodistribution and dosimetry of (18)F-EF5 in cancer patients with preliminary comparison of (18)F-EF5 uptake versus EF5 binding in human glioblastoma.
European journal of nuclear medicine and molecular imaging 20101101
-
Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302.
Biological trace element research 20100901
-
Imaging of hypoxic lesions in patients with gliomas by using positron emission tomography with 1-(2-[18F] fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole, a new 18F-labeled 2-nitroimidazole analog.
Journal of neurosurgery 20100801
-
PET imaging of hypoxia using [18F]HX4: a phase I trial.
European journal of nuclear medicine and molecular imaging 20100801
-
Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma.
British journal of cancer 20100629
-
Development of new anti-tuberculosis drug candidates.
The Tohoku journal of experimental medicine 20100601
-
The Relationship among Hypoxia, Proliferation, and Outcome in Patients with De Novo Glioblastoma: A Pilot Study.
Translational oncology 20100601
-
Fixed drug eruption with ornidazole having cross-sensitivity to secnidazole but not to other nitro-imidazole compounds: a case report.
British journal of clinical pharmacology 20100601
-
Nitroimidazole conjugates of bis(thiosemicarbazonato)64Cu(II) - Potential combination agents for the PET imaging of hypoxia.
Journal of inorganic biochemistry 20100201
-
The distribution of the therapeutic monoclonal antibodies cetuximab and trastuzumab within solid tumors.
BMC cancer 20100101
-
Hypoxia-specific targets in cancer therapy: role of splice variants.
BMC medicine 20100101
-
Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens.
PloS one 20100101
-
Synthesis and cloxacillin antimicrobial enhancement of 2-methylsulfonylimidazolyl-1,4-dihydropyridine derivatives.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20100101
-
A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy.
British journal of cancer 20091201
-
A submarine journey: the pyrrole-imidazole alkaloids.
Marine drugs 20091201
-
Design of silicon-based misonidazole analogues and (18)F-radiolabelling.
Nuclear medicine and biology 20091101
-
Interventions for prevention of post-operative recurrence of Crohn's disease.
The Cochrane database of systematic reviews 20091007
-
Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer.
Cancer chemotherapy and pharmacology 20091001
-
Molecular imaging of hypoxia with radiolabelled agents.
European journal of nuclear medicine and molecular imaging 20091001
-
Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours.
British journal of cancer 20090818
-
Nitroimidazole-based bioreductive compounds bearing a quinazoline or a naphthyridine chromophore.
Anti-cancer drugs 20090701
-
Production of superoxide anions by keratinocytes initiates P. acnes-induced inflammation of the skin.
PLoS pathogens 20090701
-
Imaging and Targeting of the Hypoxia-inducible Factor 1-active Microenvironment.
Journal of toxicologic pathology 20090601
-
Control of pore size and functionality in isoreticular zeolitic imidazolate frameworks and their carbon dioxide selective capture properties.
Journal of the American Chemical Society 20090325
-
Ultra performance liquid chromatography tandem mass spectrometry performance evaluation for analysis of antibiotics in natural waters.
Analytical and bioanalytical chemistry 20090301
-
Synthesis and hypoxia selective radiosensitization potential of beta-2-FAZA and beta-3-FAZL: fluorinated azomycin beta-nucleosides.
Medicinal chemistry (Shariqah (United Arab Emirates)) 20090301
-
Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy.
PloS one 20090101
-
Genotoxicity revaluation of three commercial nitroheterocyclic drugs: nifurtimox, benznidazole, and metronidazole.
Journal of parasitology research 20090101
-
The novel hypoxic cell radiosensitizer, TX-1877 has antitumor activity through suppression of angiogenesis and inhibits liver metastasis on xenograft model of pancreatic cancer.
Cancer letters 20081218
-
Comparative pharmacokinetics, biodistribution, metabolism and hypoxia-dependent uptake of [18F]-EF3 and [18F]-MISO in rodent tumor models.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20081201
-
Imaging and analytical methods as applied to the evaluation of vasculature and hypoxia in human brain tumors.
Radiation research 20081201
-
On the isolation and evaluation of a novel unsubstituted 5-nitroimidazole derivative as an agent to target tumor hypoxia.
Bioorganic & medicinal chemistry letters 20081001
-
Regulation of cell survival and death signals induced by oxidative stress.
Journal of clinical biochemistry and nutrition 20080901
-
1,2-Bis[2-(2-nitro-1H-imidazol-1-yl)eth-oxy]ethane.
Acta crystallographica. Section E, Structure reports online 20080901
-
FDG uptake, a surrogate of tumour hypoxia?
European journal of nuclear medicine and molecular imaging 20080801
-
O-(tert-Butyl-dimethyl-silyl)tris-(O-4-methyl-phenyl-sulfon-yl)penta-erythritol.
Acta crystallographica. Section E, Structure reports online 20080801
-
Reactions of NO(2)Cl with imidazole: a model study for the corresponding reactions of guanine.
The journal of physical chemistry. B 20080703
-
Determination of tumour hypoxia with [18F]EF3 in patients with head and neck tumours: a phase I study to assess the tracer pharmacokinetics, biodistribution and metabolism.
European journal of nuclear medicine and molecular imaging 20080701
-
Bactericidal activity of 2-nitroimidazole against the active replicating stage of Mycobacterium bovis BCG and Mycobacterium tuberculosis with intracellular efficacy in THP-1 macrophages.
International journal of antimicrobial agents 20080701
-
Design of antiangiogenic hypoxic cell radiosensitizers: 2-nitroimidazoles containing a 2-aminomethylene-4-cyclopentene-1,3-dione moiety.
Bioorganic & medicinal chemistry 20080601
-
Stereospecific deuteration of alpha-furanosyl azomycin nucleosides: a model reaction for tritium radiolabeling.
Bioorganic & medicinal chemistry letters 20080601
-
Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs.
Journal of medicinal chemistry 20080424
-
Novel nitroheterocyclic hypoxic markers for solid tumor: synthesis and biological evaluation.
Bioorganic & medicinal chemistry 20080315
-
Design, synthesis, and radiosensitizing activities of sugar-hybrid hypoxic cell radiosensitizers.
Bioorganic & medicinal chemistry 20080115
-
NLNQ-1, a 2-[3-(2-nitro-1-imidazolyl) propylamino]-3-chloro-1,4-naphthoquinone, as a hypoxia-selective cytotoxin and radiosensitizer.
In vivo (Athens, Greece) 20080101
-
Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints.
Arthritis research & therapy 20080101
-
Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome.
International journal of radiation oncology, biology, physics 20071115
-
Determination of tumour hypoxia with the PET tracer [18F]EF3: improvement of the tumour-to-background ratio in a mouse tumour model.
European journal of nuclear medicine and molecular imaging 20070901
-
Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase.
PLoS biology 20070801
-
Imaging oxygenation of human tumours.
European radiology 20070401
-
In situ oxygen utilization in the rat intervertebral disc.
Journal of anatomy 20070301
-
From 'Hellstrom Paradox' to anti-adenosinergic cancer immunotherapy.
Purinergic signalling 20070301
-
Tacrolimus (FK506) limits accumulation of granulocytes and platelets and protects against brain damage after transient focal cerebral ischemia in rat.
Biological & pharmaceutical bulletin 20070201
-
Initial evaluation of dynamic human imaging using 18F-FRP170 as a new PET tracer for imaging hypoxia.
Annals of nuclear medicine 20070201
-
Imaging of tumor hypoxia with [124I]IAZA in comparison with [18F]FMISO and [18F]FAZA--first small animal PET results.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20070101
-
The radiosensitizing effect of doranidazole on human colorectal cancer cells exposed to high doses of irradiation.
BMC cancer 20070101
-
Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia.
PloS one 20070101
-
In vivo evaluation of the nitroimidazole-based thioflavin-T derivatives as cerebral ischemia markers.
International journal of biomedical imaging 20070101
-
Oxygen levels in normal and previously irradiated human skin as assessed by EF5 binding.
The Journal of investigative dermatology 20061201
-
Ruthenium(III) maltolato-nitroimidazole complexes: synthesis and biological activity.
Journal of inorganic biochemistry 20061201
-
Azanonaboranes containing imidazole derivatives for boron neutron capture therapy: synthesis, characterization, and in vitro toxicity evaluation.
Chemistry (Weinheim an der Bergstrasse, Germany) 20061025
-
Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation.
British journal of cancer 20061023
-
Review article: recurrence of Crohn's disease after surgery - the need for treatment of new lesions.
Alimentary pharmacology & therapeutics 20061001
-
Temporal and topographic profiles of tissue hypoxia following transient focal cerebral ischemia in rats.
The Journal of veterinary medical science 20060801
-
Reaction of azole heterocycles with tris(dimethylamino)borane, a new method for the construction of tripodal borate-centred ligands.
Chemistry (Weinheim an der Bergstrasse, Germany) 20060705
-
Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
PLoS computational biology 20060601
-
Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding.
Bioorganic & medicinal chemistry 20060501
-
Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor.
Bioorganic & medicinal chemistry letters 20060315
-
EF5 binding and clinical outcome in human soft tissue sarcomas.
International journal of radiation oncology, biology, physics 20060301
-
Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension.
Cellular microbiology 20060201
-
Establishment and characterization of multicellular spheroids from a human glioma cell line; Implications for tumor therapy.
Journal of translational medicine 20060101
-
Reevaluation of the radiosensitizing effects of sanazole and nimorazole in vitro and in vivo.
Journal of radiation research 20051201
-
TX-1877, a bifunctional hypoxic cell radiosensitizer, enhances anticancer host response: immune cell migration and nitric oxide production.
International journal of cancer 20050910
-
Modulation of intratumoral hypoxia by the epidermal growth factor receptor inhibitor gefitinib detected using small animal PET imaging.
Molecular cancer therapeutics 20050901
-
Synthesis, in vitro-antimycobacterial activity and cytotoxicity of some alkyl alpha-(5-aryl-1, 3, 4-thiadiazole-2-ylthio)acetates.
Archiv der Pharmazie 20050301
-
A one-pot synthesis of 1-alpha- and 1-beta-D-arabinofuranosyl-2-nitroimidazoles: synthons to the markers of tumor hypoxia.
Nucleosides, nucleotides & nucleic acids 20050101
-
HEGPOL: randomized, placebo controlled, multicenter, double-blind clinical trial to investigate hepatoprotective effects of glycine in the postoperative phase of liver transplantation [ISRCTN69350312].
BMC surgery 20050101
-
Hypoxia is important in the biology and aggression of human glial brain tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 20041215
-
Evaluation of hypoxia in an experimental rat tumour model by [(18)F]fluoromisonidazole PET and immunohistochemistry.
British journal of cancer 20041129
-
Angiogenesis inhibitor TX-1898: syntheses of the enantiomers of sterically diverse haloacetylcarbamoyl-2-nitroimidazole hypoxic cell radiosensitizers.
Bioorganic & medicinal chemistry 20040915
-
Preclinical validation of the hypoxia tracer 2-(2-nitroimidazol-1-yl)- N-(3,3,3-[(18)F]trifluoropropyl)acetamide, [(18)F]EF3.
European journal of nuclear medicine and molecular imaging 20040901
-
Overexpression of dimethylarginine dimethylaminohydrolase enhances tumor hypoxia: an insight into the relationship of hypoxia and angiogenesis in vivo.
Neoplasia (New York, N.Y.) 20040701
-
In vivo evaluation of [18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography.
British journal of cancer 20040601
-
Propargylic sulfones possessing a 2-nitroimidazole function: novel hypoxic-cell radiosensitizers with intracellular non-protein thiol depletion ability.
Bioorganic & medicinal chemistry letters 20040517
-
In vitro activity of Etanidazole against the protozoan parasite Trypanosoma cruzi.
Memorias do Instituto Oswaldo Cruz 20040301
-
Evidence that involucrin, a marker for differentiation, is oxygen regulated in human squamous cell carcinomas.
British journal of cancer 20040209
-
Overexpression of VEGF121, but not VEGF165 or FGF-1, improves oxygenation in MCF-7 breast tumours.
British journal of cancer 20040126
-
The farnesyltransferase inhibitor R115777 reduces hypoxia and matrix metalloproteinase 2 expression in human glioma xenograft.
Clinical cancer research : an official journal of the American Association for Cancer Research 20031201
-
A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy.
Clinical cancer research : an official journal of the American Association for Cancer Research 20031101
-
Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK.
British journal of cancer 20030804
-
Pimonidazole binding in C6 rat brain glioma: relation with lipid droplet detection.
British journal of cancer 20030506
-
99mTcO(BAT-NI), a novel nitroimidazole tracer: in vivo uptake studies in ischaemic myocardium.
European journal of nuclear medicine and molecular imaging 20030401
-
In vivo colocalization of 2-nitroimidazole EF5 fluorescence intensity and electron paramagnetic resonance oximetry in mouse tumors.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20030401
-
Noninvasive imaging of tumor hypoxia in rats using the 2-nitroimidazole 18F-EF5.
European journal of nuclear medicine and molecular imaging 20030201
-
A novel hypoxia-dependent 2-nitroimidazole KIN-841 inhibits tumour-specific angiogenesis by blocking production of angiogenic factors.
British journal of cancer 20030127
-
Non-invasive PET and SPECT imaging of tissue hypoxia using isotopically labeled 2-nitroimidazoles.
Advances in experimental medicine and biology 20030101
-
Monitoring the synthetic reaction of a polyamide/peptide conjugate using electrospray ionization mass spectrometry.
Rapid communications in mass spectrometry : RCM 20030101
-
Genetic algorithm applied to the selection of factors in principal component-artificial neural networks: application to QSAR study of calcium channel antagonist activity of 1,4-dihydropyridines (nifedipine analogous).
Journal of chemical information and computer sciences 20030101
-
Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.
Cancer research 20021201
-
Quantitative structure-activity relationship study of recently synthesized 1,4-dihydropyridine calcium channel antagonists. Application of the Hansch analysis method.
Archiv der Pharmazie 20021201
-
Adduct of 2-[18F]FDG and 2-nitroimidazole as a putative radiotracer for the detection of hypoxia with PET: synthesis, in vitro- and in vivo-characterization.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20021101
-
[99mTc]Technetium labelled PnAo-azomycin glucuronides: a novel class of imaging markers of tissue hypoxia.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20021101
-
DNA-targeted 2-nitroimidazoles: studies of the influence of the phenanthridine-linked nitroimidazoles, 2-NLP-3 and 2-NLP-4, on DNA damage induced by ionizing radiation.
Radiation research 20020901
-
Phase 1 study to identify tumour hypoxia in patients with head and neck cancer using technetium-99m BRU 59-21.
European journal of nuclear medicine and molecular imaging 20020901
-
Validation of the fluorinated 2-nitroimidazole SR-4554 as a noninvasive hypoxia marker detected by magnetic resonance spectroscopy.
Clinical cancer research : an official journal of the American Association for Cancer Research 20020701
-
Zonal image analysis of tumour vascular perfusion, hypoxia, and necrosis.
British journal of cancer 20020605
-
The synthesis and radiolabeling of 2-nitroimidazole derivatives of cyclam and their preclinical evaluation as positive markers of tumor hypoxia.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20020601
-
Effect of a hypoxic cell sensitizer doranidazole on the radiation-induced apoptosis of mouse L5178Y lymphoma cells.
Journal of radiation research 20020601
-
Comparison of hypoxic cell radiosensitizers, KIN-804, KIN-844, KIN-806 and TX-1877, on brain and liver metabolizing capacities in mice bearing Ehrlich ascites carcinoma.
Biological & pharmaceutical bulletin 20020501
-
Synthesis and antihypertensive activities of new 1,4-dihydropyridine containing nitroimidazolyl substituent with a nitrooxy group at the 3-ester position.
Archiv der Pharmazie 20020301
-
Radiation-chemical properties of the hypoxic cell radiosensitizer doranidazole (PR-350).
Journal of radiation research 20020301
-
Isolation and characterization of 2-nitroimidazole produced by Streptomyces species as an inhibitor of both carbonic anhydrase and shell formation in the barnacle Balanus amphitrite.
Marine biotechnology (New York, N.Y.) 20020301
-
Imaging of ischemic but viable myocardium using a new 18F-labeled 2-nitroimidazole analog, 18F-FRP170.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20020101
-
Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and 2-nitroimidazole EF5.
Methods in enzymology 20020101
-
Synthesis and calcium channel antagonist activity of 1,4-dihydropyridine derivatives containing 4-nitroimidazolyl substituents.
Arzneimittel-Forschung 20020101
-
Bench-to-bedside review: Cytopathic hypoxia.
Critical care (London, England) 20020101
-
Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation.
American journal of clinical oncology 20011001
-
Imaging hypoxia in tumors.
Seminars in nuclear medicine 20011001
-
Pharmacokinetics of EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] in human patients: implications for hypoxia measurements in vivo by 2-nitroimidazoles.
Cancer chemotherapy and pharmacology 20010901
-
Fluorescent charge-neutral analogue of xanthosine: synthesis of a 2'-deoxyribonucleoside bearing a 5-aza-7-deazaxanthine base.
The Journal of organic chemistry 20010727
-
Low pO2 and beta-estradiol induce VEGF in MCF-7 and MCF-7-5C cells: relationship to in vivo hypoxia.
Breast cancer research and treatment 20010501
-
Hypoxia in radiation-induced blood-spinal cord barrier breakdown.
Cancer research 20010415
-
Autonomic nervous system and gut-derived endotoxin: involvement in activation of Kupffer cells after in situ organ manipulation.
World journal of surgery 20010401
-
The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras.
Cancer research 20010301
-
Hypoxia in human intraperitoneal and extremity sarcomas.
International journal of radiation oncology, biology, physics 20010201
-
New antimetastatic hypoxic cell radiosensitizers: design, synthesis, and biological activities of 2-nitroimidazole-acetamide, TX-1877, and its analogues.
Bioorganic & medicinal chemistry 20010201
-
Phase Ia study of a hypoxic cell sensitizer doranidazole (PR-350) in combination with conventional radiotherapy.
Anti-cancer drugs 20010101
-
Bioequivalence assessment of Azomycin (Julphar, UAE) as compared to Zithromax (Pfizer, USA)--two brands of azithromycin--in healthy human volunteers.
Biopharmaceutics & drug disposition 20010101
-
Antituberculosis activity of certain antifungal and antihelmintic drugs.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 19990101
-
Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.
Annals of tropical medicine and parasitology 19961201
-
Screening for new compounds with antiherpes activity.
Antiviral research 19841001
