528-43-8 | 2-[2-hydroxy-5-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$13.00	$9.00
5g	98%	in stock	$28.00	$19.00
10g	98%	in stock	$30.00	$21.00
25g	98%	in stock	$73.00	$51.00
100g	98%	in stock	$201.00	$141.00
500g	98%	in stock	$758.00	$531.00

Description

• Catalog Number: AB46401
• Chemical Name: 2-[2-hydroxy-5-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol
• CAS Number: 528-43-8
• Molecular Formula: C18H18O2
• Molecular Weight: 266.3343
• MDL Number: MFCD00016658
• SMILES: C=CCc1ccc(c(c1)c1cc(CC=C)ccc1O)O
• NSC Number: 293099

Computed Properties

• Complexity: 293
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 5
• XLogP3: 5

Literature

• Magnolol protects pancreatic β-cells against methylglyoxal-induced cellular dysfunction.

  Chemico-biological interactions 20171101

• Assessment of the inhibition potential of Licochalcone A against human UDP-glucuronosyltransferases.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20160401

• Magnolol protects against trimethyltin-induced neuronal damage and glial activation in vitro and in vivo.

  Neurotoxicology 20160301

• Magnolol attenuates neointima formation by inducing cell cycle arrest via inhibition of ERK1/2 and NF-kappaB activation in vascular smooth muscle cells.

  Biochimica et biophysica acta 20130301

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice.

  Neuropharmacology 20121101

• Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9.

  Xenobiotica; the fate of foreign compounds in biological systems 20121001

• Anti-hepatitis B virus constituents from the stem bark of Streblus asper.

  Phytochemistry 20121001

• Modulation of P-glycoprotein expression by honokiol, magnolol and 4-O-methylhonokiol, the bioactive components of Magnolia officinalis.

  Anticancer research 20121001

• The antiplatelet activity of magnolol is mediated by PPAR-β/γ.

  Biochemical pharmacology 20120915

• Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats.

  Chinese journal of integrative medicine 20120901

• The effect of magnolol on the Toll-like receptor 4/nuclear factor κB signaling pathway in lipopolysaccharide-induced acute lung injury in mice.

  European journal of pharmacology 20120815

• Antidepressant-like effect of magnolol on BDNF up-regulation and serotonergic system activity in unpredictable chronic mild stress treated rats.

  Phytotherapy research : PTR 20120801

• Human breast cancer cell metastasis is attenuated by lysyl oxidase inhibitors through down-regulation of focal adhesion kinase and the paxillin-signaling pathway.

  Breast cancer research and treatment 20120801

• Wnt/β-catenin signaling mediates the antitumor activity of magnolol in colorectal cancer cells.

  Molecular pharmacology 20120801

• Comparative studies on the interactions of honokiol and magnolol with human serum albumin.

  Journal of pharmaceutical and biomedical analysis 20120701

• Magnolol attenuates the lung injury in hypertonic saline treatment from mesenteric ischemia reperfusion through diminishing iNOS.

  The Journal of surgical research 20120615

• Magnolol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity through activation of mitochondrial function.

  Inflammation 20120601

• The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABA(A) receptors.

  Neuropharmacology 20120601

• Inhibitory effects of magnolol on voltage-gated Na+ and K+ channels of NG108-15 cells.

  European journal of pharmacology 20120505

• Design and synthesis of novel magnolol derivatives as potential antimicrobial and antiproliferative compounds.

  European journal of medicinal chemistry 20120501

• Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways.

  International journal of oncology 20120401

• Bioactive polar compounds from stem bark of Magnolia officinalis.

  Fitoterapia 20120301

• Characterization of hepatic and intestinal glucuronidation of magnolol: application of the relative activity factor approach to decipher the contributions of multiple UDP-glucuronosyltransferase isoforms.

  Drug metabolism and disposition: the biological fate of chemicals 20120301

• Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity.

  Bioorganic & medicinal chemistry letters 20120201

• A simple LC-MS/MS method for determination of magnolol in rat blood and its application in a pharmacokinetic study.

  Arzneimittel-Forschung 20120201

• The inhibition of eugenol on glucan is essential for the biofilm eradication effect on caries-related biofilm in an artificial mouth model.

  Natural product research 20120101

• Anti-inflammatory effects of active constituents extracted from Chinese medicinal herbs against Propionibacterium acnes.

  Natural product research 20120101

• Effects of magnolol on vascular contraction in rat aortic rings.

  Clinical and experimental pharmacology & physiology 20120101

• Quality assessment of commercial Magnoliae officinalis Cortex by ¹H-NMR-based metabolomics and HPLC methods.

  Phytochemical analysis : PCA 20120101

• Separation and determination of honokiol and magnolol in Chinese traditional medicines by capillary electrophoresis with the application of response surface methodology and radial basis function neural network.

  Journal of chromatographic science 20120101

• Protein kinases and transcription factors activation in response to UV-radiation of skin: implications for carcinogenesis.

  International journal of molecular sciences 20120101

• Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models.

  Journal of neuroinflammation 20120101

• Anti-arthritic effects of magnolol in human interleukin 1β-stimulated fibroblast-like synoviocytes and in a rat arthritis model.

  PloS one 20120101

• Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation.

  Journal of neuroinflammation 20120101

• Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Effect of magnolol on the function of osteoblastic MC3T3-E1 cells.

  Mediators of inflammation 20120101

• Response of methicillin-resistant Staphylococcus aureus to amicoumacin A.

  PloS one 20120101

• Interaction of avelox with bovine serum albumin and effect of the coexistent drugs on the reaction.

  International journal of analytical chemistry 20120101

• Porphyromonas gingivalis Fimbria-Induced Expression of Inflammatory Cytokines and Cyclooxygenase-2 in Mouse Macrophages and Its Inhibition by the Bioactive Compounds Fibronectin and Melatonin.

  ISRN dentistry 20120101

• Application of ionic liquids in the microwave-assisted extraction of proanthocyanidins from Larix gmelini bark.

  International journal of molecular sciences 20120101

• Magnolol Protects against MPTP/MPP(+)-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson's Disease.

  Parkinson's disease 20120101

• Nutrition, inflammation, and infectious disease.

  Mediators of inflammation 20120101

• Visualizing sweetness: increasingly diverse applications for fluorescent-tagged glucose bioprobes and their recent structural modifications.

  Sensors (Basel, Switzerland) 20120101

• Honokiol and magnolol stimulate glucose uptake by activating PI3K-dependent Akt in L6 myotubes.

  BioFactors (Oxford, England) 20120101

• Magnolol reduces glutamate-induced neuronal excitotoxicity and protects against permanent focal cerebral ischemia up to 4 hours.

  PloS one 20120101

• Cardiovascular protection of magnolol: cell-type specificity and dose-related effects.

  Journal of biomedical science 20120101

• Magnolol-induced apoptosis in HCT-116 colon cancer cells is associated with the AMP-activated protein kinase signaling pathway.

  Biological & pharmaceutical bulletin 20120101

• Bioactive compounds from natural resources against skin aging.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20111215

• Magnolol-loaded core-shell hydrogel nanoparticles: drug release, intracellular uptake, and controlled cytotoxicity for the inhibition of migration of vascular smooth muscle cells.

  Molecular pharmaceutics 20111205

• Magnolol down-regulates HER2 gene expression, leading to inhibition of HER2-mediated metastatic potential in ovarian cancer cells.

  Cancer letters 20111201

• Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts antiepileptic effects via the GABA/benzodiazepine receptor complex in mice.

  British journal of pharmacology 20111101

• Pharmacokinetics, bioavailability, and tissue distribution of magnolol following single and repeated dosing of magnolol to rats.

  Planta medica 20111101

• Comparison of antioxidant abilities of magnolol and honokiol to scavenge radicals and to protect DNA.

  Biochimie 20111001

• Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of Magnolia officinalis.

  Drug discoveries & therapeutics 20111001

• Magnolia dealbata Zucc and its active principles honokiol and magnolol stimulate glucose uptake in murine and human adipocytes using the insulin-signaling pathway.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20110815

• Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol.

  Bioorganic & medicinal chemistry letters 20110815

• Modulation of GABAA-receptors by honokiol and derivatives: subtype selectivity and structure-activity relationship.

  Journal of medicinal chemistry 20110811

• Antimicrobial activity and cytotoxic effects of Magnolia dealbata and its active compounds.

  Natural product communications 20110801

• The effect of preconditioning on liver regeneration after hepatic resection in cirrhotic rats.

  The Korean journal of hepatology 20110601

• Therapeutic applications of compounds in the Magnolia family.

  Pharmacology & therapeutics 20110501

• Simultaneous quantification of marker components in Ojeok-san by HPLC-DAD.

  Journal of natural medicines 20110401

• Effect of traditional Chinese medicinal herbs on Candida spp. from patients with HIV/AIDS.

  Advances in dental research 20110401

• Anticancer potential of magnolol for lung cancer treatment.

  Archives of pharmacal research 20110401

• Hypertonic saline and reduced peroxynitrite formation in experimental pancreatitis.

  Clinics (Sao Paulo, Brazil) 20110301

• Evaluation of oxygen radical absorbance capacity in kampo medicine.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Distinct photoacidity of honokiol from magnolol.

  Journal of fluorescence 20110101

• Protective Mechanism of KIOM-4 in Streptozotocin-Induced Pancreatic β-Cells Damage Is Involved in the Inhibition of Endoplasmic Reticulum Stress.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Electrochemical detection of honokiol and magnolol in traditional Chinese medicines using acetylene black nanoparticle-modified electrode.

  Phytochemical analysis : PCA 20110101

• Combination of Medicinal Herbs KIOM-79 Reduces Advanced Glycation End Product Accumulation and the Expression of Inflammatory Factors in the Aorta of Zucker Diabetic Fatty Rats.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Protective and restorative effects of magnolol on neurotoxicity in mice with 6-hydroxydopamine-induced hemiparkinsonism.

  Neuro-degenerative diseases 20110101

• C-kit binding properties of hesperidin (a major component of KMP6) as a potential anti-allergic agent.

  PloS one 20110101

• Honokiol crosses BBB and BCSFB, and inhibits brain tumor growth in rat 9L intracerebral gliosarcoma model and human U251 xenograft glioma model.

  PloS one 20110101

• Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts.

  PloS one 20110101

• Cathelicidin-BF, a snake cathelicidin-derived antimicrobial peptide, could be an excellent therapeutic agent for acne vulgaris.

  PloS one 20110101

• KIOM-4 Protects against Oxidative Stress-Induced Mitochondrial Damage in Pancreatic β-cells via Its Antioxidant Effects.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• JNK suppression is essential for 17β-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells.

  Journal of biomedical science 20110101

• Hepatoprotective activity of the Phyllanthus species on tert-butyl hydroperoxide (t-BH)-induced cytotoxicity in HepG2 cells.

  Pharmacognosy magazine 20110101

• Effect of herbal extract granules combined with probiotic mixture on irritable bowel syndrome with diarrhea: study protocol for a randomized controlled trial.

  Trials 20110101

• Effects of magnolol on UVB-induced skin cancer development in mice and its possible mechanism of action.

  BMC cancer 20110101

• Transcriptional and functional analysis of the effects of magnolol: inhibition of autolysis and biofilms in Staphylococcus aureus.

  PloS one 20110101

• Tat peptide-admixed elastic liposomal formulation of hirsutenone for the treatment of atopic dermatitis in NC/Nga mice.

  International journal of nanomedicine 20110101

• Molecular determinants of magnolol targeting both RXRα and PPARγ.

  PloS one 20110101

• Neurotrophic activity of obovatol on the cultured embryonic rat neuronal cells by increase of neurotrophin release through activation of ERK pathway.

  European journal of pharmacology 20101215

• Magnolol Inhibits LPS-induced NF-κB/Rel Activation by Blocking p38 Kinase in Murine Macrophages.

  The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20101201

• [Variation of phenolic compound contents of Magnolia officinalis at different levels].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101101

• Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells.

  Phytotherapy research : PTR 20101001

• Separation of honokiol and magnolol by intermittent counter-current extraction.

  Journal of chromatography. A 20100917

• Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders.

  Molecules (Basel, Switzerland) 20100916

• Beneficial effects of magnolol in a rodent model of endotoxin shock.

  European journal of pharmacology 20100901

• Substituted dineolignans from Magnolia garrettii.

  Journal of natural products 20100827

• [Effect of compound Chinese traditional medicine on infected root canal bacteria biofilm].

  Shanghai kou qiang yi xue = Shanghai journal of stomatology 20100801

• Hydrophobic ionic liquid-based ultrasound-assisted extraction of magnolol and honokiol from cortex Magnoliae officinalis.

  Journal of separation science 20100701

• [Effects of primary processing on quality of cortex Magnolia officinalis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100701

• Protecting skin photoaging by NF-kappaB inhibitor.

  Current drug metabolism 20100601

• Peroxyl radical scavenging capacity of extracts and isolated components from selected medicinal plants.

  Archives of pharmacal research 20100601

• Inhibitory effect of magnolol on TPA-induced skin inflammation and tumor promotion in mice.

  Journal of agricultural and food chemistry 20100512

• High concentration of magnolol induces hepatotoxicity under serum-reduced conditions.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20100501

• Pharmacokinetic comparison in rats of six bioactive compounds between Da-Cheng-Qi decoction and its parent herbal medicines.

  Natural product communications 20100501

• Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor gamma.

  Molecular pharmacology 20100401

• Simultaneous analysis of nine components in patch preparations of Ru-Yi-Jin-Huang-San by high-performance liquid chromatography.

  Journal of natural medicines 20100401

• [The intervention effects of different drugs on dendritic cells in acute pancreatitis in mouse].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20100401

• Studies of UPLC fingerprint for the identification of Magnoliae officinalis cortex processed.

  Pharmacognosy magazine 20100401

• Influence of magnolol on the secretion of alpha-toxin by Staphylococcus aureus.

  Molecules (Basel, Switzerland) 20100312

• Micronization of magnolia bark extract with enhanced dissolution behavior by rapid expansion of supercritical solution.

  Chemical & pharmaceutical bulletin 20100201

• Honokiol and magnolol production by in vitro micropropagated plants of Magnolia dealbata, an endangered endemic Mexican species.

  Natural product communications 20100201

• Influence of Magnolol on the bystander effect induced by alpha-particle irradiation.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20100101

• Quality assurance for Chinese herbal formulae: standardization of IBS-20, a 20-herb preparation.

  Chinese medicine 20100101

• Magnolol suppresses metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in PC-3 human prostate carcinoma cells.

  Bioscience, biotechnology, and biochemistry 20100101

• Stem cell-based neuroprotective and neurorestorative strategies.

  International journal of molecular sciences 20100101

• Quasi-drugs developed in Japan for the prevention or treatment of hyperpigmentary disorders.

  International journal of molecular sciences 20100101

• A Validated RP HPLC-PAD Method for the Determination of Hederacoside C in Ivy-Thyme Cough Syrup.

  International journal of analytical chemistry 20100101

• Integrating findings of traditional medicine with modern pharmaceutical research: the potential role of linked open data.

  Chinese medicine 20100101

• Interaction of bioactive coomassie brilliant blue g with protein: insights from spectroscopic methods.

  Scientia pharmaceutica 20100101

• Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components.

  World journal of gastroenterology 20091221

• Magnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice.

  Brain research 20091211

• Neurite outgrowth effect of 4-O-methylhonokiol by induction of neurotrophic factors through ERK activation.

  Neurochemical research 20091201

• Magnolol induces apoptosis via activation of both mitochondrial and death receptor pathways in A375-S2 cells.

  Archives of pharmacal research 20091201

• Potent and selective inhibition of the tumor marker AKR1B10 by bisdemethoxycurcumin: probing the active site of the enzyme with molecular modeling and site-directed mutagenesis.

  Biochemical and biophysical research communications 20091106

• The protective efficacy of magnolol in hind limb ischemia-reperfusion injury.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20091001

• [Effects of tree ages and geographic area on quality of bark of Magnolia officinalis and M. officinalis var. biloba].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091001

• Magnolol enhances pentobarbital-induced sleeping behaviors: possible involvement of GABAergic systems.

  Phytotherapy research : PTR 20090901

• Combined administration of the mixture of honokiol and magnolol and ginger oil evokes antidepressant-like synergism in rats.

  Archives of pharmacal research 20090901

• Magnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1.

  Journal of agricultural and food chemistry 20090826

• Anti-inflammatory effect of 4-O-methylhonokiol, compound isolated from Magnolia officinalis through inhibition of NF-kappaB [corrected].

  Chemico-biological interactions 20090814

• Simultaneous determination of the 10 major components of Da-Cheng-Qi decoction in dog plasma by liquid chromatography tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090715

• Inhibitory effect of magnolol on Trp-P-2-induced DNA damage in various organs in mice.

  Phytotherapy research : PTR 20090701

• Magnolol depresses urotensin-II-induced cell proliferation in rat cardiac fibroblasts.

  Clinical and experimental pharmacology & physiology 20090701

• Antineoplastic effects of Magnoliae officinalis in tumours other than hepatomas.

  Liver international : official journal of the International Association for the Study of the Liver 20090701

• Protective effect of the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on scopolamine-induced memory impairment and the inhibition of acetylcholinesterase activity.

  Journal of natural medicines 20090701

• Anti-clastogenic effect of magnolol-containing Hange-koboku-to, Dai-joki-to, Goshaku-san, and Magnoliae Cortex on benzo(a)pyrene-induced clastogenicity in mice.

  Biological & pharmaceutical bulletin 20090701

• Production of honokiol and magnolol in suspension cultures of Magnolia dealbata Zucc.

  Natural product communications 20090701

• Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells.

  Life sciences 20090619

• Antidepressant-like synergism of extracts from magnolia bark and ginger rhizome alone and in combination in mice.

  Progress in neuro-psychopharmacology & biological psychiatry 20090615

• Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts.

  Cardiovascular research 20090601

• Effects of neolignans from the stem bark of Magnolia obovata on plant pathogenic fungi.

  Journal of applied microbiology 20090601

• Effects of mixed herbal extracts from parched Puerariae radix, gingered Magnoliae cortex, Glycyrrhizae radix and Euphorbiae radix (KIOM-79) on cardiac ion channels and action potentials.

  Journal of Korean medical science 20090601

• Honokiol, a multifunctional antiangiogenic and antitumor agent.

  Antioxidants & redox signaling 20090501

• Lysophosphatidylcholine exhibits selective cytotoxicity, accompanied by ROS formation, in RAW 264.7 macrophages.

  Lipids 20090501

• [Micronization of magnolia bark extract by RESS as well as dissolution and pharmacokinetics evaluation].

  Yao xue xue bao = Acta pharmaceutica Sinica 20090501

• Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells.

  Journal of cellular biochemistry 20090415

• Neolignans from North American Magnolia species with cyclooxygenase 2 inhibitory activity.

  Inflammopharmacology 20090401

• Honokiol reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element binding protein-1c and the expression of its downstream lipogenesis genes.

  Toxicology and applied pharmacology 20090401

• Magnolia officinalis reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element-binding protein-1c.

  Journal of pharmacological sciences 20090401

• Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet.

  Diabetes 20090301

• Regulation of contractile activity by magnolol in the rat isolated gastrointestinal tracts.

  Pharmacological research 20090301

• Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.

  Analytica chimica acta 20090202

• Complementary and alternative medicine: herbs, phytochemicals and vitamins and their immunologic effects.

  The Journal of allergy and clinical immunology 20090201

• Antioxidative and hepatoprotective effects of magnolol on acetaminophen-induced liver damage in rats.

  Archives of pharmacal research 20090201

• Phenolic constituents from the stem bark of Magnolia officinalis.

  Journal of natural products 20090101

• In vitro drug release behavior from a novel thermosensitive composite hydrogel based on Pluronic f127 and poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) copolymer.

  BMC biotechnology 20090101

• [Simultaneous determination of seven effective component in Houpuwenzhong capsules using high performance liquid chromatography].

  Se pu = Chinese journal of chromatography 20090101

• Cadmium induces lung inflammation independent of lung cell proliferation: a molecular approach.

  Journal of inflammation (London, England) 20090101

• Protective effect of magnolol against hydrogen peroxide-induced oxidative stress in human lens epithelial cells.

  The American journal of Chinese medicine 20090101

• Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain.

  Journal of biomedical science 20090101

• Magnolol attenuates sepsis-induced gastrointestinal dysmotility in rats by modulating inflammatory mediators.

  World journal of gastroenterology 20081228

• Signaling pathway for TNF-alpha-induced MMP-9 expression: mediation through p38 MAP kinase, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells.

  International immunopharmacology 20081220

• Simultaneous determination of 12 chemical constituents in the traditional Chinese Medicinal Prescription Xiao-Yao-San-Jia-Wei by HPLC coupled with photodiode array detection.

  Journal of pharmaceutical and biomedical analysis 20081215

• Anti-apoptotic effect of magnolol in myocardial ischemia and reperfusion injury requires extracellular signal-regulated kinase1/2 pathways in rat in vivo.

  Experimental biology and medicine (Maywood, N.J.) 20081001

• Obovatol inhibits colorectal cancer growth by inhibiting tumor cell proliferation and inducing apoptosis.

  Bioorganic & medicinal chemistry 20080915

• Voltammetric detection of magnolol in Chinese medicine based on the enhancement effect of mesoporous Al/SiO(2)-modified electrode.

  Colloids and surfaces. B, Biointerfaces 20080901

• [Effects of storage time on magnolol and honokiol contents in bark of Magnolia officinalis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

• Rapid simultaneous quantification of five active constituents in rat plasma by high-performance liquid chromatography/tandem mass spectrometry after oral administration of Da-Cheng-Qi decoction.

  Journal of pharmaceutical and biomedical analysis 20080715

• Magnolol elicits activation of the extracellular signal-regulated kinase pathway by inducing p27KIP1-mediated G2/M-phase cell cycle arrest in human urinary bladder cancer 5637 cells.

  Biochemical pharmacology 20080615

• 1H and 13C NMR assignments for two lignans from the heartwood of Streblus asper.

  Magnetic resonance in chemistry : MRC 20080501

• [Studies on chemical constituents and volatile oil of Xiaochengqi decoction].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501

• Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents.

  Progress in neuro-psychopharmacology & biological psychiatry 20080401

• HPLC-based activity profiling approach for the discovery of GABAA receptor ligands using an automated two microelectrode voltage clamp assay on Xenopus oocytes.

  Planta medica 20080401

• Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-kappaB.

  European journal of pharmacology 20080317

• Magnolol and honokiol account for the anti-spasmodic effect of Magnolia officinalis in isolated guinea pig ileum.

  Planta medica 20080301

• Anti-clastogenic effect of magnolol on benzo(a)pyrene-induced clastogenicity in mice.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080201

• [Phenols in seedling cortex of Magnolia officinalis from Enshi].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080201

• Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial.

  Nutrition journal 20080101

• Simultaneous determination of eight major bioactive compounds in Dachengqi Tang (DT) by high-performance liquid chromatography.

  Chinese medicine 20080101

• JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin.

  Journal of inflammation (London, England) 20080101

• Improved therapeutic effectiveness by combining liposomal honokiol with cisplatin in lung cancer model.

  BMC cancer 20080101

• Antimicrobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia.

  Chinese medicine 20080101

• Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration.

  Journal of inflammation research 20080101

• Spectroscopic investigation of inner filter effect by magnolol solutions.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071231

• Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract.

  Regulatory toxicology and pharmacology : RTP 20071201

• Magnolol-induced H460 cells death via autophagy but not apoptosis.

  Archives of pharmacal research 20071201

• Compressed mints and chewing gum containing magnolia bark extract are effective against bacteria responsible for oral malodor.

  Journal of agricultural and food chemistry 20071114

• Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors.

  Biological & pharmaceutical bulletin 20071101

• Cytotoxic lignans from the stem bark of Magnolia officinalis.

  Journal of natural products 20071001

• Pharmacological activity of cardiovascular agents from herbal medicine.

  Cardiovascular & hematological agents in medicinal chemistry 20071001

• Effects of honokiol and magnolol on acute and inflammatory pain models in mice.

  Life sciences 20070908

• Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.

  Journal of medicinal chemistry 20070823

• Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.

  Bioorganic & medicinal chemistry letters 20070815

• Inhibitory role of magnolol on proliferative capacity and matrix metalloproteinase-9 expression in TNF-alpha-induced vascular smooth muscle cells.

  International immunopharmacology 20070801

• Mechanisms for the magnolol-induced cell death of CGTH W-2 thyroid carcinoma cells.

  Journal of cellular biochemistry 20070701

• Protective effect of magnolol on TBHP-induced injury in H460 cells partially via a p53 dependent mechanism.

  Archives of pharmacal research 20070701

• Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB.

  European journal of pharmacology 20070622

• Protective effects of magnolol against oxidized LDL-induced apoptosis in endothelial cells.

  Archives of toxicology 20070601

• [Effects of the active compounds of M. officinalis on cariogenic bacteria].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20070601

• Effect of magnolol on TGF-beta1 and fibronectin expression in human retinal pigment epithelial cells under diabetic conditions.

  European journal of pharmacology 20070507

• Magnolol suppresses NF-kappaB activation and NF-kappaB regulated gene expression through inhibition of IkappaB kinase activation.

  Molecular immunology 20070401

• Involvement of Ras/Raf-1/ERK actions in the magnolol-induced upregulation of p21 and cell-cycle arrest in colon cancer cells.

  Molecular carcinogenesis 20070401

• Rapid purification and scale-up of honokiol and magnolol using high-capacity high-speed counter-current chromatography.

  Journal of chromatography. A 20070223

• Analysis of magnolol and honokiol in biological fluids by capillary zone electrophoresis.

  Journal of chromatography. A 20070223

• Effects of magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl) on diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats.

  Life sciences 20070109

• Antiproliferative and pro-apoptotic activity of eugenol-related biphenyls on malignant melanoma cells.

  Molecular cancer 20070101

• Oxidative stress and ischemic injuries in heat stroke.

  Progress in brain research 20070101

• Agmatine protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell line.

  BMC neuroscience 20070101

• Liquid chromatographic determination of honokiol and magnolol in hou po (Magnolia officinalis) as the raw herb and dried aqueous extract.

  Journal of AOAC International 20070101

• Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth.

  PloS one 20070101

• Magnolol-induced apoptosis is mediated via the intrinsic pathway with release of AIF from mitochondria in U937 cells.

  Biological & pharmaceutical bulletin 20061201

• Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.

  Annals of the New York Academy of Sciences 20061201

• [Investigate into of effective constituent transference of herba Ephedrae and cortex Magnoliae officinalis in preparation course of Shujin Kechuan capsule].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201

• Anti-inflammatory effects of different drugs/agents with antioxidant property on endothelial expression of adhesion molecules.

  Cardiovascular & hematological disorders drug targets 20061201

• Nitric oxide-independent lipid metabolism in RAW 264.7 macrophages loaded with oleic acid.

  Cell biology international 20061101

• Determination of liquiritin, naringin, hesperidin, thymol, imperatorin, honokiol, isoimperatorin, and magnolol in the traditional Chinese medicinal preparation Huoxiang-zhengqi liquid using high-performance liquid chromatography.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20061101

• In vitro anti-mutagenic effect of magnolol against direct and indirect mutagens.

  Mutation research 20061010

• Simultaneous determination of honokiol and magnolol in Magnolia officinalis by liquid chromatography with tandem mass spectrometric detection.

  Biomedical chromatography : BMC 20061001

• The inhibitory effect of magnolol from Magnolia officinalis on glucosyltransferase.

  Archives of oral biology 20061001

• [Evaluation of antioxidant activity of Radix Linderae and other two Chinese drugs using TLC-bioautography].

  Yao xue xue bao = Acta pharmaceutica Sinica 20061001

• [Optimization of preparative technique for banxia-houpu effervescent tablets by orthogonal design].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20061001

• Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway.

  Molecular cancer research : MCR 20060901

• Carbon nanotube/poly(methyl methacrylate) composite electrode for capillary electrophoretic measurement of honokiol and magnolol in Cortex Magnoliae Officinalis.

  Electrophoresis 20060801

• [Inhibition of extracts from 17 Chinese herbs on periodontal pathogenic microbes].

  Shanghai kou qiang yi xue = Shanghai journal of stomatology 20060801

• Determination of honokiol and magnolol in cortex Magnoliae Officinalis by capillary electrophoresis with electrochemical detection.

  Journal of pharmaceutical and biomedical analysis 20060616

• Facile purification of honokiol and its antiviral and cytotoxic properties.

  Journal of medicinal chemistry 20060601

• Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage.

  European journal of pharmacology 20060510

• Herbal remedy magnolol suppresses IL-6-induced STAT3 activation and gene expression in endothelial cells.

  British journal of pharmacology 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Separation and determination of honokiol and magnolol in herbal medicines by flow injection-capillary electrophoresis.

  Analytical and bioanalytical chemistry 20060401

• Inhibitory effects of magnolol on distal colon of guinea pig in vitro.

  Biological & pharmaceutical bulletin 20060401

• A comparative study of upright counter-current chromatography and high-performance liquid chromatograpohy for preparative isolation and purification ofphenolic compounds from Magnoliae officinalis.

  Journal of separation science 20060201

• Ethnoveterinary medicines used for horses in Trinidad and in British Columbia, Canada.

  Journal of ethnobiology and ethnomedicine 20060101

• Elucidating the inhibitory mechanisms of magnolol on rat smooth muscle cell proliferation.

  Journal of pharmacological sciences 20051201

• Prokinetic effect of a Kampo medicine, Hange-koboku-to (Banxia-houpo-tang), on patients with functional dyspepsia.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20051101

• Differential inhibitory effects of honokiol and magnolol on excitatory amino acid-evoked cation signals and NMDA-induced seizures.

  Neuropharmacology 20050901

• Neurotrophic effect of magnolol in the hippocampal CA1 region of senescence-accelerated mice (SAMP1).

  Biological & pharmaceutical bulletin 20050901

• Signaling pathways of magnolol-induced adrenal steroidogensis.

  FEBS letters 20050815

• Effects of magnolol and honokiol derived from traditional Chinese herbal remedies on gastrointestinal movement.

  World journal of gastroenterology 20050728

• [Studies on HPLC chromatogram of phenolic constituents of Cortex Magnoliae Officinalis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050701

• Magnolol induces the distributional changes of p160 and adipose differentiation-related protein in adrenal cells.

  Histochemistry and cell biology 20050601

• Magnolol stimulates lipolysis in lipid-laden RAW 264.7 macrophages.

  Journal of cellular biochemistry 20050401

• Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling.

  Planta medica 20050401

• Determination of honokiol and magnolol by micro HPLC with electrochemical detection and its application to the distribution analysis in branches and leaves of Magnolia obovata.

  Chemical & pharmaceutical bulletin 20050301

• Magnolol and honokiol enhance HL-60 human leukemia cell differentiation induced by 1,25-dihydroxyvitamin D3 and retinoic acid.

  The international journal of biochemistry & cell biology 20050201

• Lignans and their degraded derivatives from Sarcostemma acidum.

  Journal of natural products 20050201

• Cytotoxic neolignans: an SAR study.

  Bioorganic & medicinal chemistry letters 20050103

• Magnolol alters the course of endotoxin tolerance and provides early protection against endotoxin challenge following sublethal hemorrhage in rats.

  Shock (Augusta, Ga.) 20041001

• In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp.

  European journal of pharmacology 20040802

• Isolation and purification of honokiol and magnolol from cortex Magnoliae officinalis by high-speed counter-current chromatography.

  Journal of chromatography. A 20040521

• Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes.

  Journal of cellular biochemistry 20040401

• Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.

  Journal of ethnopharmacology 20040401

• Mechanisms of the influence of magnolol on eicosanoid metabolism in neutrophils.

  Biochemical pharmacology 20040301

• Antimicrobial and cytotoxic activities of neolignans from Magnolia officinalis.

  Chemistry & biodiversity 20040301

• Effects of Magnolol and Honokiol on the activities of streptococcal glucosyltransferases both in solution and adsorbed on an experimental pellicle.

  Letters in applied microbiology 20040101

• Inhibitory action of ICI-182,780, an estrogen receptor antagonist, on BK(Ca) channel activity in cultured endothelial cells of human coronary artery.

  Biochemical pharmacology 20031115

• Metabolites of orally administered Magnolia officinalis extract in rats and man and its antidepressant-like effects in mice.

  The Journal of pharmacy and pharmacology 20031101

• The mechanism of honokiol-induced and magnolol-induced inhibition on muscle contraction and Ca2+ mobilization in rat uterus.

  Naunyn-Schmiedeberg's archives of pharmacology 20031001

• Magnolol alters cytokine response after hemorrhagic shock and increases survival in subsequent intraabdominal sepsis in rats.

  Shock (Augusta, Ga.) 20030901

• Inhibitory effect of magnolol on tumour metastasis in mice.

  Phytotherapy research : PTR 20030901

• Allylmagnolol, a novel magnolol derivative as potent antioxidant.

  Bioorganic & medicinal chemistry 20030815

• Honokiol and magnolol induce Ca2+ mobilization in rat cortical neurons and human neuroblastoma SH-SY5Y cells.

  European journal of pharmacology 20030808

• Magnolol induces apoptosis in vascular smooth muscle.

  Naunyn-Schmiedeberg's archives of pharmacology 20030801

• Interaction of magnolol with bovine serum albumin: a fluorescence-quenching study.

  Analytical and bioanalytical chemistry 20030701

• Inhibition of smooth muscle contraction by magnolol and honokiol in porcine trachea.

  Planta medica 20030601

• The protective mechanism of magnolol, a Chinese herb drug, against warm ischemia-reperfusion injury of rat liver.

  The Journal of surgical research 20030401

• Magnolol induces apoptosis in human leukemia cells via cytochrome c release and caspase activation.

  Anti-cancer drugs 20030301

• High-performance liquid chromatographic method for simultaneous determination of honokiol and magnolol in rat plasma.

  Talanta 20030102

• Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells.

  British journal of pharmacology 20030101

• Protective effects of honokiol and magnolol on tertiary butyl hydroperoxide- or D-galactosamine-induced toxicity in rat primary hepatocytes.

  Planta medica 20030101

• Magnolol protects against cerebral ischaemic injury of rat heatstroke.

  Clinical and experimental pharmacology & physiology 20030101

• Magnolol has the ability to induce apoptosis in tumor cells.

  Biological & pharmaceutical bulletin 20021201

• Synthesis and radical scavenging of novel magnolol derivatives.

  The Journal of pharmacy and pharmacology 20021201

• Protective effect of magnolol on the small intestinal ischemia-reperfusion injury.

  Transplantation proceedings 20021101

• [Study on HPLC-FPS of cortex magnoliae officinalis].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020901

• Anti-platelet effect of the constituents isolated from the barks and fruits of Magnolia obovata.

  Archives of pharmacal research 20020601

• [Quality evaluation and utilization of germplasm resources of Magnolia officinalis].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020201

• Magnolol attenuates VCAM-1 expression in vitro in TNF-alpha-treated human aortic endothelial cells and in vivo in the aorta of cholesterol-fed rabbits.

  British journal of pharmacology 20020101

• Stimulation of the BK(Ca) channel in cultured smooth muscle cells of human trachea by magnolol.

  Thorax 20020101

• Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis.

  Journal of cellular biochemistry 20020101

• Inhibitory effect of magnolol and honokiol from Magnolia obovata on human fibrosarcoma HT-1080. Invasiveness in vitro.

  Planta medica 20011101

• Effects of the extract of the bark of Magnolia obovata and its biphenolic constituents magnolol and honokiol on histamine release from peritoneal mast cells in rats.

  Planta medica 20011101

• An anxiolytic agent, dihydrohonokiol-B, inhibits ammonia-induced increases in the intracellular Cl(-) of cultured rat hippocampal neurons via GABA(c) receptors.

  Neuroscience letters 20011019

• Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells.

  Molecular carcinogenesis 20011001

• Honokiol and magnolol selectively interact with GABAA receptor subtypes in vitro.

  Pharmacology 20010701

• Magnolol, a potent antioxidant from Magnolia officinalis, attenuates intimal thickening and MCP-1 expression after balloon injury of the aorta in cholesterol-fed rabbits.

  Basic research in cardiology 20010701

• Magnolol reduces myocardial ischemia/reperfusion injury via neutrophil inhibition in rats.

  European journal of pharmacology 20010622

• Effects of constituents from the bark of Magnolia obovata on nitric oxide production in lipopolysaccharide-activated macrophages.

  Chemical & pharmaceutical bulletin 20010601

• Antimicrobial activity of honokiol and magnolol isolated from Magnolia officinalis.

  Phytotherapy research : PTR 20010301

• Effects of absorbed components of saiboku-to on the release of leukotrienes from polymorphonuclear leukocytes of patients with bronchial asthma.

  Methods and findings in experimental and clinical pharmacology 20010301

• [Selection of optimal extraction process for magnolol by orthogonal design].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20010301

• Magnolol from Magnolia officinalis inhibits 11beta-hydroxysteroid dehydrogenase without increases of corticosterone and thymocyte apoptosis in mice.

  Planta medica 20010201

• Pretreatment with magnolol attenuates ischemia-reperfusion injury in rat small intestine.

  Transplantation proceedings 20010101

• Antifungal activity of magnolol and honokiol.

  Archives of pharmacal research 20000201

• Magnolol reduces infarct size and suppresses ventricular arrhythmia in rats subjected to coronary ligation.

  Clinical and experimental pharmacology & physiology 19960801