5305-40-8 | 4,6-Dichloro-5-pyrimidinecarbaldehyde

Packsize	Purity	Availability	Price	Discounted Price
10g	98%	in stock	$11.00	$8.00
25g	98%	in stock	$24.00	$17.00
100g	98%	in stock	$90.00	$63.00

Description

• Catalog Number: AB66385
• Chemical Name: 4,6-Dichloro-5-pyrimidinecarbaldehyde
• CAS Number: 5305-40-8
• Molecular Formula: C5H2Cl2N2O
• Molecular Weight: 176.9882
• MDL Number: MFCD02257701
• SMILES: O=Cc1c(Cl)ncnc1Cl

Computed Properties

• Complexity: 123
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• XLogP3: 1.6

Upstream Synthesis Route

The 4,6-Dichloro-5-pyrimidinecarboxaldehyde is a crucial compound widely used in chemical synthesis processes. It serves as a versatile building block in the creation of various pharmaceuticals, agrochemicals, and specialty chemicals. Due to its unique structure, this compound plays a vital role in the production of heterocyclic compounds, particularly in the pharmaceutical industry.One important application of 4,6-Dichloro-5-pyrimidinecarboxaldehyde is its use as a key intermediate in the synthesis of pyrimidine-based drugs. It can undergo various chemical reactions to introduce different functional groups, leading to the formation of novel bioactive compounds with potential therapeutic properties. Additionally, this compound can participate in cross-coupling reactions, cyclization processes, and other transformations to yield complex molecules with diverse biological activities.Moreover, 4,6-Dichloro-5-pyrimidinecarboxaldehyde can be utilized in the preparation of herbicides, insecticides, and fungicides due to its role in constructing active ingredients with pesticidal properties. Its chemical reactivity and compatibility with different synthetic routes make it a valuable tool in the development of crop protection agents and agricultural chemicals.Overall, the application of 4,6-Dichloro-5-pyrimidinecarboxaldehyde in chemical synthesis showcases its significance in the creation of structurally diverse compounds with potential applications in the pharmaceutical and agrochemical sectors.

Literature

• Synthesis of highly substituted 2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-ones from 4,6-dichloro-5-formylpyrimidine, amines and aldehydes.

  Molecular diversity 20111101

• Expanding the diversity of allosteric bcr-abl inhibitors.

  Journal of medicinal chemistry 20101014