533-75-5 | Tropolone

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$8.00	$5.00
5g	98%	in stock	$10.00	$7.00
10g	98%	in stock	$20.00	$14.00
25g	98%	in stock	$40.00	$28.00
100g	98%	in stock	$132.00	$92.00
500g	98%	in stock	$615.00	$430.00

Description

• Catalog Number: AB53178
• Chemical Name: Tropolone
• CAS Number: 533-75-5
• Molecular Formula: C7H6O2
• Molecular Weight: 122.1213
• MDL Number: MFCD00004158
• SMILES: Oc1cccccc1=O
• NSC Number: 89303

Computed Properties

• Complexity: 209
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 0.5

Upstream Synthesis Route

2-Hydroxycyclohepta-2,4,6-trienone, also known as tropolon, is a versatile compound widely utilized in chemical synthesis. Its unique molecular structure and reactivity make it a valuable tool in various organic reactions. In particular, 2-Hydroxycyclohepta-2,4,6-trienone serves as a key intermediate in the synthesis of heterocyclic compounds, such as benzofurans and benzothiophenes. Additionally, it is commonly employed in the construction of complex natural products due to its ability to participate in diverse types of transformations, including Friedel-Crafts acylation, Diels-Alder reactions, and oxidative coupling reactions. The presence of both a hydroxyl group and a conjugated carbonyl moiety in this molecule enables it to engage in a range of chemical processes, leading to the formation of structurally diverse and biologically relevant molecules.

Literature

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  Organic & biomolecular chemistry 20171219

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  Environmental toxicology 20160101

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  Human immunology 20121001

• Transport of the anti-diabetic VO2+ complexes formed by pyrone derivatives in the blood serum.

  Journal of inorganic biochemistry 20121001

• Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis.

  Proceedings of the National Academy of Sciences of the United States of America 20120515

• Pycnidione, a fungus-derived agent, induces cell cycle arrest and apoptosis in A549 human lung cancer cells.

  Chemico-biological interactions 20120415

• 5-(Phenyl-diazen-yl)tropolone.

  Acta crystallographica. Section E, Structure reports online 20120401

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  World journal of microbiology & biotechnology 20120401

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  Journal of medicinal chemistry 20110714

• Solid-state thiotropolone: an extremely rapid intramolecular proton transfer.

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• Crystal structure of Agaricus bisporus mushroom tyrosinase: identity of the tetramer subunits and interaction with tropolone.

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• Bis[2-(methyl-amino)-troponato]copper(II).

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• Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins.

  Bioorganic & medicinal chemistry 20101115

• A microwave study of hydrogen-transfer-triggered methyl-group rotation in 5-methyltropolone.

  The Journal of chemical physics 20101114

• catena-Poly[(μ(3)-2-hy-droxy-4-isopropyl-cyclo-hepta-2,4,6-trien-1-onato)(μ(2)-2-hy-droxy-4-isopropyl-cyclo-hepta-2,4,6-trien-1-onato)lead(II)].

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• 1-(2-Hy-droxy-eth-yl)-3-(3-meth-oxy-phen-yl)thio-urea.

  Acta crystallographica. Section E, Structure reports online 20101001

• Vibrational specificity of proton-transfer dynamics in ground-state tropolone.

  Physical chemistry chemical physics : PCCP 20100801

• Studies on the anti-hepatitis C virus activity of newly synthesized tropolone derivatives: identification of NS3 helicase inhibitors that specifically inhibit subgenomic HCV replication.

  Bioorganic & medicinal chemistry 20100715

• Tetra-ethyl-ammonium bromidotricarbon-yl(tropolonato)rhenate(I).

  Acta crystallographica. Section E, Structure reports online 20100701

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  PLoS biology 20100601

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• In vitro skin permeation of hinokitiol loaded in vesicles composed of behenyltrimethylammonium chloride and stearic acid.

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  Viruses 20100401

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• Biomimetic formation of 2-tropolones by dioxygenase-catalysed ring expansion of substituted 2,4-cyclohexadienones.

  Chembiochem : a European journal of chemical biology 20100125

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  Chemical & pharmaceutical bulletin 20100101

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  Anticancer research 20100101

• Hormetic and anti-radiation effects of tropolone-related compounds.

  In vivo (Athens, Greece) 20100101

• New strategies for the treatment of hepatitis C virus infection and implications of resistance to new direct-acting antiviral agents.

  Infection and drug resistance 20100101

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  Cancer letters 20091228

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  Structure (London, England : 1993) 20091209

• Benzo[cd]azulene skeleton: azulene, heptafulvene, and tropone derivatives.

  Organic letters 20091203

• Microwave spectrum of the argon-tropolone van der Waals complex.

  The journal of physical chemistry. A 20091126

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  Journal of agricultural and food chemistry 20090624

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  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090601

• An updated review of tyrosinase inhibitors.

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• Chiral photochemistry within a confined space: diastereoselective photorearrangements of a tropolone and a cyclohexadienone included in a synthetic cavitand.

  Dalton transactions (Cambridge, England : 2003) 20090528

• Volatile and non-volatile monoterpenes produced by elicitor-stimulated Cupressus lusitanica cultured cells.

  Journal of plant physiology 20090501

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  Developmental and comparative immunology 20090501

• Pernambucone, a new tropone derivative from Croton argyroglossum.

  Die Pharmazie 20090501

• Theoretical study of proton tunneling in the excited state of tropolone.

  The Journal of chemical physics 20090428

• An exploration of electronic structure and nuclear dynamics in tropolone: II. The A (1)B2 (pi* pi) excited state.

  The Journal of chemical physics 20090414

• A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds.

  European journal of medicinal chemistry 20090401

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  Anticancer research 20090401

• Bis[tris-(4-fluoro-phen-yl)phosphine-κP](tropolonato-κO,O')copper(I).

  Acta crystallographica. Section E, Structure reports online 20090401

• Novel 3,4-diazabenzotropone compounds (2,3-benzodiazepin-5-ones): synthesis, unique reactivity, and biological evaluation.

  Organic letters 20090319

• Theoretical study on the stability of formylphenol and formylaniline compounds and corresponding radicals: O-H or N-H vs C-H bond dissociation.

  The journal of physical chemistry. A 20090226

• Bis(triphenyl-phosphine-κP)(tropolonato-κO,O')silver(I) dichloro-methane solvate.

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  The Journal of organic chemistry 20090116

• Targeting mitochondrial permeability in cancer drug development.

  Molecular nutrition & food research 20090101

• Effect of tropolone, azulene and azulenequinone derivatives on prostaglandin E2 production by activated macrophage-like cells.

  Anticancer research 20090101

• Cell tracking and therapy evaluation of bone marrow monocytes and stromal cells using SPECT and CMR in a canine model of myocardial infarction.

  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20090101

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  Journal of cosmetic science 20090101

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  Journal of the American Chemical Society 20081112

• Steinernema carpocapsae DD136: metabolites limit the non-self adhesion responses of haemocytes of two lepidopteran larvae, Galleria mellonella (F. Pyralidae) and Malacosoma disstria (F. Lasiocampidae).

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• The prophenoloxidase system is activated during the tunic inflammatory reaction of Ciona intestinalis.

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• High production of beta-thujaplicin glycosides by immobilized plant cells of Nicotiana tabacum.

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  Organic letters 20080821

• In vivo hair growth promotion effects of cosmetic preparations containing hinokitiol-loaded poly(epsilon-caprolacton) nanocapsules.

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• Electronic modification of an aminotroponiminate zinc complex leading to an increased reactivity in the hydroamination of alkenes.

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  Planta medica 20080601

• Tetra-kis(1,1,1-trifluoro-acetyl-acetonato-κO,O')zirconium(IV) toluene solvate.

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  Biological & pharmaceutical bulletin 20080401

• On the sulfation and methylation of catecholestrogens in human mammary epithelial cells and breast cancer cells.

  Biological & pharmaceutical bulletin 20080401

• Noreupenifeldin, a tropolone from an unidentified ascomycete.

  Journal of natural products 20080301

• Agglutinin-mediated phagocytosis-associated generation of superoxide anion and nitric oxide by the hemocytes of the giant freshwater prawn Macrobrachium rosenbergii.

  Fish & shellfish immunology 20080301

• Tunneling splittings for 'O...O stretching' and other vibrations of tropolone isotopomers observed in the infrared spectrum below 800 cm(-1).

  The journal of physical chemistry. A 20080221

• A fresh look at natural tropolonoids.

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  Bioorganic & medicinal chemistry 20080201

• pH-dependent inhibition of mushroom tyrosinase by N-substituted N-nitrosohydroxylamines.

  Journal of enzyme inhibition and medicinal chemistry 20080201

• Computational studies of the tropone natural products, thiotropocin, tropodithietic acid, and troposulfenin. Significance of thiocarbonyl-enol tautomerism.

  The Journal of organic chemistry 20080104

• Synthesis of 4-aminotropones from [(sulfinyl or sulfonyl)methyl]-substituted p-quinamines.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• Imaging of gene expression in live pancreatic islet cell lines using dual-isotope SPECT.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080101

• In vitro permeation study of hinokitiol: effects of vehicles and enhancers.

  Drug delivery 20080101

• Bonding in tropolone, 2-aminotropone, and aminotroponimine: no evidence of resonance-assisted hydrogen-bond effects.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• Polyphenol oxidase from wheat bran is a serpin.

  Acta biochimica Polonica 20080101

• Crystal structures of 2-aminotropone, n,n'-di(tropon-2-yl)piperazine, and 5-(4-ethoxyphenylazo)tropolone.

  Journal of oleo science 20080101

• A strategy to protect and sensitize near-infrared luminescent Nd3+ and Yb3+: organic tropolonate ligands for the sensitization of Ln(3+)-doped NaYF4 nanocrystals.

  Journal of the American Chemical Society 20071205

• Synthesis and in vitro protozoocidal evaluation of novel diazabicyclic tropolone derivatives.

  Archiv der Pharmazie 20071101

• Tolerance to Bacillus thuringiensis endotoxin in immune-suppressed larvae of the flour moth Ephestia kuehniella.

  Journal of invertebrate pathology 20071001

• Melanin biosynthesis by Frankia strain CeI5.

  Physiologia plantarum 20071001

• The mechanism of the bactericidal activity of hinokitiol.

  Biocontrol science 20070901

• Mode-specific tunneling dynamics in the ground electronic state of tropolone.

  The Journal of chemical physics 20070828

• A new access to dihydrotropones through ring expansion of spirocyclohexadienones: synthesis and mechanism.

  The Journal of organic chemistry 20070817

• Growth inhibitory effect of shelf life extending agents on Bacillus subtilis IAM 1026.

  Biocontrol science 20070601

• Cytotoxicity of colchicine derivatives in primary cultures of human hepatocytes.

  Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20070601

• Influence of pH and counteranion on the structure of tropolonato-lead(II) complexes: structural and infrared characterization of formed lead compounds.

  Inorganic chemistry 20070528

• Three-coordinated aminotroponiminate and aminotroponate complexes of gold(I).

  Inorganic chemistry 20070528

• Value of zeolites in asymmetric induction during photocyclization of pyridones, cyclohexadienones and naphthalenones.

  Organic & biomolecular chemistry 20070521

• Optimisation of pressurised liquid extraction for elimination of sulphur interferences during determination of organotin compounds in sulphur-rich sediments by gas chromatography with flame photometric detection.

  Chemosphere 20070501

• Certification of butyltins and phenyltins in marine sediment certified reference material by species-specific isotope-dilution mass spectrometric analysis using synthesized 118Sn-enriched organotin compounds.

  Analytical and bioanalytical chemistry 20070401

• Demonstration of a true phenoloxidase activity and activation of a ProPO cascade in Pacific oyster, Crassostrea gigas (Thunberg) in vitro.

  Fish & shellfish immunology 20070401

• UV-visible and 1H or 13C NMR spectroscopic studies on the specific interaction between lithium ions and the anion from tropolone or 4-isopropyltropolone (hinokitiol) and on the formation of protonated tropolones in acetonitrile or other solvents.

  The journal of physical chemistry. B 20070222

• Tropolone and its derivatives as inhibitors of the helicase activity of hepatitis C virus nucleotide triphosphatase/helicase.

  Antiviral chemistry & chemotherapy 20070101

• Reactive oxygen species, nitric oxide, and their interactions play different roles in Cupressus lusitanica cell death and phytoalexin biosynthesis.

  The New phytologist 20070101

• Kinetic radical-scavenging activity of colchicine and tropolone.

  In vivo (Athens, Greece) 20070101

• Plant troponoids: chemistry, biological activity, and biosynthesis.

  Current medicinal chemistry 20070101

• A novel function for selenium in biological system: selenite as a highly effective iron carrier for Chinese hamster ovary cell growth and monoclonal antibody production.

  Biotechnology and bioengineering 20061220

• Hinokitiol, a metal chelator derived from natural plants, suppresses cell growth and disrupts androgen receptor signaling in prostate carcinoma cell lines.

  Biochemical and biophysical research communications 20061208

• Labelling of human mesenchymal stem cells with indium-111 for SPECT imaging: effect on cell proliferation and differentiation.

  European journal of nuclear medicine and molecular imaging 20061001

• Lack of hinokitiol (beta-thujaplicin) carcinogenicity in F344/DuCrj rats.

  The Journal of toxicological sciences 20061001

• Determination of tributyltin and 4-hydroxybutyldibutyltin chlorides in seawater by liquid chromatography with atmospheric pressure chemical ionization-mass spectrometry.

  Analytica chimica acta 20060925

• Differential regulation of melanosomal proteins after hinokitiol treatment.

  Journal of dermatological science 20060901

• Quantum tunneling in the midrange vibrational fundamentals of tropolone.

  The journal of physical chemistry. A 20060810

• The design of organic catalysis for epoxidation by hydrogen peroxide.

  Journal of molecular modeling 20060701

• Raman spectroscopic studies on tropolone complexes with La, Nd, Sm, Yb.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060701

• The excellence of Aomori Hiba (Hinokiasunaro) in its use as building materials of Buddhist temples and Shinto shrines.

  Biocontrol science 20060601

• An exploration of electronic structure and nuclear dynamics in tropolone. I. The X 1A1 ground state.

  The Journal of chemical physics 20060528

• The conformational state of polyphenol oxidase from field bean (Dolichos lablab) upon SDS and acid-pH activation.

  The Biochemical journal 20060501

• Preferential inhibition of the magnesium-dependent strand transfer reaction of HIV-1 integrase by alpha-hydroxytropolones.

  Molecular pharmacology 20060401

• Therapeutic effects of beta-thujaplicin eardrops on canine Malassezia-related otitis externa.

  The Journal of veterinary medical science 20060401

• Delineating the role of polyphenol oxidase in the darkening of alkaline wheat noodles.

  Journal of agricultural and food chemistry 20060322

• Searching for a new anti-HCV therapy: synthesis and properties of tropolone derivatives.

  Biochemical and biophysical research communications 20060310

• High-resolution studies of tropolone in the S0 and S1 electronic states: isotope driven dynamics in the zero-point energy levels.

  The Journal of chemical physics 20060221

• Isoelectronic homologues and isomers: tropolone, 5-azatropolone, 1-H-azepine-4,5-dione, saddle points, and ions.

  The journal of physical chemistry. A 20060202

• Signal transduction and metabolic flux of beta-thujaplicin and monoterpene biosynthesis in elicited Cupressus lusitanica cell cultures.

  Metabolic engineering 20060101

• Human metallothionein gene expression is upregulated by beta-thujaplicin: possible involvement of protein kinase C and reactive oxygen species.

  Biological & pharmaceutical bulletin 20060101

• Relationship between electronic structure and cytotoxic activity of tropolones.

  In vivo (Athens, Greece) 20060101

• Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel.

  Beilstein journal of organic chemistry 20060101

• In vitro growth inhibition of bloodstream forms of Trypanosoma brucei and Trypanosoma congolense by iron chelators.

  Kinetoplastid biology and disease 20060101

• Production of sepedonin by Sepedonium chrysospermum NT-1 in submerged culture.

  Environmental sciences : an international journal of environmental physiology and toxicology 20060101

• Arachidonate 12-lipoxygenases with reference to their selective inhibitors.

  Biochemical and biophysical research communications 20051209

• Inhibition of human immunodeficiency virus type 1 reverse transcriptase, RNase H, and integrase activities by hydroxytropolones.

  Antimicrobial agents and chemotherapy 20051201

• Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesis.

  Biological & pharmaceutical bulletin 20051201

• Prooxidant action of hinokitiol: hinokitiol-iron dependent generation of reactive oxygen species.

  Basic & clinical pharmacology & toxicology 20051201

• Effects of beta-thujaplicin on anti-Malassezia pachydermatis remedy for canine otitis externa.

  The Journal of veterinary medical science 20051201

• Mosquito larvicidal activity of active constituent derived from Chamaecyparis obtusa leaves against 3 mosquito species.

  Journal of the American Mosquito Control Association 20051201

• Efforts directed toward the synthesis of colchicine: application of palladium-catalyzed siloxane cross-coupling methodology.

  The Journal of organic chemistry 20051028

• Determining the minimum number of detectable cardiac-transplanted 111In-tropolone-labelled bone-marrow-derived mesenchymal stem cells by SPECT.

  Physics in medicine and biology 20051007

• Sgk1, a cell survival response in neurodegenerative diseases.

  Molecular and cellular neurosciences 20051001

• Potential antimalarial lead structures from fungi of marine origin.

  Planta medica 20051001

• Total synthesis of (-)-colchicine via a Rh-triggered cycloaddition cascade.

  Organic letters 20050929

• Oxidation of the flavonoid eriodictyol by tyrosinase.

  Plant physiology and biochemistry : PPB 20050901

• Role of cations and confinement in asymmetric photochemistry: enantio- and diastereo-selective photocyclization of tropolone derivatives within zeolites.

  Organic & biomolecular chemistry 20050821

• The all-Cartesian reaction plane Hamiltonian: formulation and application to the H-atom transfer in tropolone.

  The Journal of chemical physics 20050801

• Polyphenol oxidase from Dominga table grape.

  Journal of agricultural and food chemistry 20050727

• Activation of catechol-O-methyltransferase in astrocytes stimulates homocysteine synthesis and export to neurons.

  Glia 20050701

• 18O effects on the infrared spectrum and skeletal tunneling of tropolone.

  The Journal of chemical physics 20050608

• Oxidative stress in plant cell culture: a role in production of beta-thujaplicin by Cupresssus lusitanica suspension culture.

  Biotechnology and bioengineering 20050605

• Development of Animal-free, Protein-Free and Chemically-Defined Media for NS0 Cell Culture.

  Cytotechnology 20050601

• Six-coordinate titanium complexes of a tripodal aminetris(phenoxide) ligand: synthesis, structure, and dynamics.

  Inorganic chemistry 20050418

• Benzotropolone inhibitors of estradiol methylation: kinetics and in silico modeling studies.

  Bioorganic & medicinal chemistry 20050401

• Acaricidal activity of active constituent isolated in Chamaecyparis obtusa leaves against Dermatophagoides spp.

  Journal of agricultural and food chemistry 20050323

• Implications of comparative spectral doublets observed for neon-isolated and gaseous tropolone(OH) and tropolone(OD).

  The Journal of chemical physics 20050322

• Dynamical hydrogen atom tunneling in dichlorotropolone: a combined quantum, semiclassical, and classical study.

  The Journal of chemical physics 20050322

• Ring expansion of sulfur substituted p-quinamines: regiospecific synthesis of 4-aminotropones.

  Chemical communications (Cambridge, England) 20050227

• Methyl group rotation driven by proton transfer through a long-range chemical interaction.

  Angewandte Chemie (International ed. in English) 20050211

• Characterization and purification of polyphenol oxidase from artichoke (Cynara scolymus L.).

  Journal of agricultural and food chemistry 20050209

• Protection by tropolones against H2O2-induced DNA damage and apoptosis in cultured Jurkat cells.

  Free radical research 20050201

• Fungal diversity from western redcedar fences and their resistance to beta-thujaplicin.

  Antonie van Leeuwenhoek 20050201

• Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones.

  Nucleic acids research 20050101

• Anticholinesterase efficiency of some tropolone alkaloids and their lumiderivatives.

  Doklady. Biochemistry and biophysics 20050101

• Biological activity of beta-dolabrin, gamma-thujaplicin, and 4-acetyltropolone, hinokitiol-related compounds.

  Biological & pharmaceutical bulletin 20041001

• Polarization spectroscopy of gaseous tropolone in a strong electric field.

  The Journal of chemical physics 20040908

• Cerebral neutrophil recruitment, histology, and outcome in acute ischemic stroke: an imaging-based study.

  Stroke 20040701

• Biological activity of alpha-thujaplicin, the isomer of hinokitiol.

  Biological & pharmaceutical bulletin 20040601

• Rapid accumulation and metabolism of polyphosphoinositol and its possible role in phytoalexin biosynthesis in yeast elicitor-treated Cupressus lusitanica cell cultures.

  Planta 20040501

• Jasmonate and ethylene signalling and their interaction are integral parts of the elicitor signalling pathway leading to beta-thujaplicin biosynthesis in Cupressus lusitanica cell cultures.

  Journal of experimental botany 20040501

• Liquid chromatography-hydride generation-atomic absorption spectrometry for the speciation of tin in seafoods.

  Journal of environmental monitoring : JEM 20040401

• Beta-thujaplicin: new quantitative CZE method and adsorption to goethite.

  Journal of agricultural and food chemistry 20040324

• Time-dependent probability of quantum tunneling in terms of the quasisemiclassical method.

  The Journal of chemical physics 20040308

• Rotation-tunneling analysis of the origin band in the tropolone pi(*)<--pi absorption system.

  The Journal of chemical physics 20040308

• Determination of organotin compounds in biological samples using accelerated solvent extraction, sodium tetraethylborate ethylation, and multicapillary gas chromatography-flame photometric detection.

  Analytical and bioanalytical chemistry 20040301

• Evaluation of developmental toxicity of beta-thujaplicin (hinokitiol) following oral administration during organogenesis in rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040301

• (-)-Epigallocatechin-3-gallate and hinokitiol reduce melanin synthesis via decreased MITF production.

  Archives of pharmacal research 20040301

• Synthesis and structural characterization of silver(I), aluminium(III) and cobalt(II) complexes with 4-isopropyltropolone (hinokitiol) showing noteworthy biological activities. Action of silver(I)-oxygen bonding complexes on the antimicrobial activities.

  Journal of inorganic biochemistry 20040101

• Transmission electron microscopy of Schistosoma mansoni cercariae treated with hinokitiol (beta-thujaplicin), a compound for potential skin application against cercarial penetration.

  The Tohoku journal of experimental medicine 20040101

• Cytotoxic activity of deferiprone, maltol and related hydroxyketones against human tumor cell lines.

  Anticancer research 20040101

• Comparison of tropane alkaloid spectra between Datura innoxia grown in Egypt and Bulgaria.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101

• Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by tropolones.

  Anticancer research 20040101

• [Antimicrobial activity of hinokitiol against Legionella pneumophila].

  Journal of UOEH 20031201

• Biological activity of tropolone.

  Biological & pharmaceutical bulletin 20031001

• Generation of reactive oxygen species from Hinokitiol under near-UV irradiation.

  Bioscience, biotechnology, and biochemistry 20030901

• Carbon-13 CP-MAS nuclear magnetic resonance studies of teas.

  Solid state nuclear magnetic resonance 20030501

• Butyltin compounds in retail mollusc products.

  Food additives and contaminants 20030501

• Seasonal and spatial variations of alkaloids in Merendera montana in relation to chemical defense and phenology.

  Journal of chemical ecology 20030501

• Partial purification of latent persimmon fruit polyphenol oxidase.

  Journal of agricultural and food chemistry 20030326

• Adhesion of endometrial cells labeled with 111Indium-tropolonate to peritoneum: a novel in vitro model to study endometriosis.

  Fertility and sterility 20030301

• Multiple signalling pathways mediate fungal elicitor-induced beta-thujaplicin biosynthesis in Cupressus lusitanica cell cultures.

  Journal of experimental botany 20030201

• Low-level iron-dependent mutants of Listeria monocytogenes and their virulence in macrophages.

  Canadian journal of microbiology 20030201

• Antibacterial effect of beta-thujaplicin on staphylococci isolated from atopic dermatitis: relationship between changes in the number of viable bacterial cells and clinical improvement in an eczematous lesion of atopic dermatitis.

  The Journal of antimicrobial chemotherapy 20030101

• Actions of U-92032, a T-type Ca2+ channel antagonist, support a functional linkage between I(T) and slow intrathalamic rhythms.

  Journal of neurophysiology 20030101

• Improved fermentation processes for NS0 cell lines expressing human antibodies and glutamine synthetase.

  Biotechnology progress 20030101

• Synthesis and in vitro anti-protozoal activity of a series of benzotropolone derivatives incorporating endocyclic hydrazines.

  European journal of medicinal chemistry 20030101

• Cytotoxic activity of tropolones against human oral tumor cell lines.

  Anticancer research 20030101

• Tyrosinase-mediated oxidation of acetaminophen to 4-acetamido-o-benzoquinone.

  Biological chemistry 20021201

• Biomimetic cycloaddition approach to tropolone natural products via a tropolone ortho-quinone methide.

  Organic letters 20020822

• Biological activity of 4-acetyltropolone, the minor component of Thujopsis dolabrata SIeb. et Zucc. hondai Mak.

  Biological & pharmaceutical bulletin 20020801

• One-step stereoselective synthesis and NMR chiral shift properties of a novel hexacoordinated phosphorus cation.

  Organic letters 20020711

• Feedback regulation of beta-thujaplicin production and formation of its methyl ether in a suspension culture of Cupressus lusitanica.

  Phytochemistry 20020701

• Enantioselective photoreaction of achiral tropolone ether in inclusion crystals with optically active host compounds.

  Chirality 20020701

• Synthesis of new azulene derivatives and study of their effect on lipid peroxidation and lipoxygenase activity.

  Chemical & pharmaceutical bulletin 20020701

• Selective preconcentration and determination of tributyltin in fresh water by electrothermal atomic absorption spectrometry.

  Analytical and bioanalytical chemistry 20020401

• Role of tyrosinase in the genoprotective effect of the edible mushroom, Agaricus bisporus.

  Life sciences 20020222

• Diagnostic value of (111)In-granulocyte scintigraphy in patients with fever of unknown origin.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20020201

• Application of Lewis acid catalyzed tropone [6+4] cycloadditions to the synthesis of the core of CP-225,917.

  Organic letters 20011227

• Crossover phase behavior (discotic to calamitic) in liquid-crystalline copper complexes. Dependence on the length and position of alkoxy chains in new polycatenar bis[5-(dialkoxybenzylidine)aminotropololonato]copper(II) complexes.

  Inorganic chemistry 20011203

• The impact of recent advances in immunology and cancer therapy on nuclear medicine.

  Seminars in nuclear medicine 20011001

• Abnormal platelet adhesion on abdominal vessels in asymptomatic patients with paroxysmal nocturnal hemoglobinuria.

  Annals of hematology 20011001

• Fungicidal activity of beta-thujaplicin analogues.

  Pest management science 20010901

• A new tropolone from the insect pathogenic fungus Cordyceps sp. BCC 1681.

  The Journal of antibiotics 20010901

• Synthesis and structural characterization of tin(II) and zinc(II) derivatives of cyclic alpha-hydroxyketones, including the structures of Sn(maltol)(2), Sn(tropolone)(2), Zn(tropolone)(2), and Zn(hinokitiol)(2).

  Inorganic chemistry 20010813

• Cytotoxic effects of beta-thujaplicin on rat thymocytes and prevention by the compound in tributyltin-induced thymocyte damage.

  Bulletin of environmental contamination and toxicology 20010701

• Hydroxy- or methoxy-substituted benzaldoximes and benzaldehyde-O-alkyloximes as tyrosinase inhibitors.

  Bioorganic & medicinal chemistry 20010701

• Biological activity of alpha-thujaplicin, the minor component of Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO.

  Biological & pharmaceutical bulletin 20010601

• Synthesis and biological evaluation of O-alkylated tropolones and related alpha-ketohydroxy derivatives as ribonucleotide reductase inhibitors.

  European journal of medicinal chemistry 20010601

• Synthesis of N-substituted N-nitrosohydroxylamines as inhibitors of mushroom tyrosinase.

  Bioorganic & medicinal chemistry 20010501

• Production of beta-thujaplicin in Cupressus lusitanica suspension cultures fed with organic acids and monoterpenes.

  Bioscience, biotechnology, and biochemistry 20010501

• Total synthesis of tropoloisoquinolines: imerubrine, isoimerubrine, and grandirubrine.

  Journal of the American Chemical Society 20010411

• Partial purification, characterization, and histochemical localization of fully latent desert truffle (Terfezia claveryi Chatin) polyphenol oxidase.

  Journal of agricultural and food chemistry 20010401

• Novel retinoidal tropolone derivatives. Bioisosteric relationship of tropolone ring with benzoic acid moiety in retinoid structure.

  Chemical & pharmaceutical bulletin 20010401

• Improved beta-thujaplicin production in Cupressus lusitanica suspension cultures by fungal elicitor and methyl jasmonate.

  Applied microbiology and biotechnology 20010401

• Cytotoxicity of the hinokitiol-related compounds, gamma-thujaplicin and beta-dolabrin.

  Biological & pharmaceutical bulletin 20010301

• Does the photochemical conversion of colchicine into lumicolchicines involve triplet transients? A solvent dependence study.

  Photochemistry and photobiology 20010301

• Effects of tolcapone upon soluble and membrane-bound brain and liver catechol-O-methyltransferase.

  Brain research 19990306

• Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3.

  Cell proliferation 19990201

• Thujaplicin-copper chelates inhibit replication of human influenza viruses.

  Antiviral research 19980801

• A new model of ventricular fibrillation induced by isoprenaline and catechol-O-methyl transferase inhibitor at a high perfusion temperature in isolated rat hearts.

  Journal of pharmacological methods 19851201