536-71-0 | 4,4'-(Triaz-1-ene-1,3-diyl)dibenzimidamide

Packsize	Purity	Availability	Price	Discounted Price
1g	99%	2 weeks	$23.00	$16.00
5g	99%	2 weeks	$39.00	$27.00
25g	99%	2 weeks	$98.00	$69.00
100g	99%	2 weeks	$243.00	$170.00

Description

• Catalog Number: AB52530
• Chemical Name: 4,4'-(Triaz-1-ene-1,3-diyl)dibenzimidamide
• CAS Number: 536-71-0
• Molecular Formula: C14H15N7
• Molecular Weight: 281.3158
• MDL Number: MFCD00866606
• SMILES: NC(=N)c1ccc(cc1)N/N=N/c1ccc(cc1)C(=N)N

Computed Properties

• Complexity: 390
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 5
• Rotatable Bond Count: 5
• XLogP3: 1.9

Literature

• Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms.

  Arteriosclerosis, thrombosis, and vascular biology 20141201

• Is trypanocidal drug resistance a threat for livestock health and production in endemic areas? Food for thoughts from Sahelian goats infected by Trypanosoma vivax in Bobo Dioulasso (Burkina Faso).

  Veterinary parasitology 20121221

• Comparative serum biochemical changes induced by experimental infection of T. brucei and T. congolense in pigs.

  Veterinary parasitology 20121221

• Ghibe river basin in Ethiopia: present situation of trypanocidal drug resistance in Trypanosoma congolense using tests in mice and PCR-RFLP.

  Veterinary parasitology 20121026

• Involvement of mitochondrial genes of Babesia gibsoni in resistance to diminazene aceturate.

  The Journal of veterinary medical science 20120901

• Purification of plasmid DNA from clarified and non-clarified Escherichia coli lysates by berenil pseudo-affinity chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901

• Analysis of energy generation and glycolysis pathway in diminazene aceturate-resistant Babesia gibsoni isolate in vitro.

  The Japanese journal of veterinary research 20120801

• Field detection of resistance to isometamidium chloride and diminazene aceturate in Trypanosoma vivax from the region of the Boucle du Mouhoun in Burkina Faso.

  Veterinary parasitology 20120608

• The therapeutic efficacy of two antibabesial strategies against Babesia gibsoni.

  Veterinary parasitology 20120525

• Modeling the control of trypanosomiasis using trypanocides or insecticide-treated livestock.

  PLoS neglected tropical diseases 20120501

• Development of in vitro atovaquone-resistant Babesia gibsoni with a single-nucleotide polymorphism in cytb.

  Veterinary parasitology 20120430

• Energetics of ligand binding to the DNA minor groove.

  Physical chemistry chemical physics : PCCP 20120428

• Current advances in detection and treatment of babesiosis.

  Current medicinal chemistry 20120401

• Quinol derivatives as potential trypanocidal agents.

  Bioorganic & medicinal chemistry 20120215

• Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP.

  Bioorganic & medicinal chemistry letters 20120115

• Highly debilitating natural Trypanosoma vivax infections in Brazilian calves: epidemiology, pathology, and probable transplacental transmission.

  Parasitology research 20120101

• Comparison of protective immune responses to apicomplexan parasites.

  Journal of parasitology research 20120101

• Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery.

  Journal of drug delivery 20120101

• Validation of an HPLC method for the simultaneous determination of diminazene diaceturate and phenazone in injectable veterinary granules and bulk powders.

  Pakistan journal of pharmaceutical sciences 20120101

• The Trypanosoma cruzi virulence factor oligopeptidase B (OPBTc) assembles into an active and stable dimer.

  PloS one 20120101

• How full is our antihypertensives pipeline?

  Journal of pharmacology & pharmacotherapeutics 20120101

• Detection of multiple drug-resistant Trypanosoma congolense populations in village cattle of south-east Mali.

  Parasites & vectors 20120101

• Biological activities of xanthatin from Xanthium strumarium leaves.

  Phytotherapy research : PTR 20111201

• Biodynamic parameters of micellar diminazene in sheep erythrocytes and blood plasma.

  Journal of veterinary science 20111201

• High prevalence of drug resistance in animal trypanosomes without a history of drug exposure.

  PLoS neglected tropical diseases 20111201

• Susceptibility of mice to Trypanosoma evansi treated with human plasma containing different concentrations of apolipoprotein L-1.

  The Korean journal of parasitology 20111201

• Convolutamines I and J, antitrypanosomal alkaloids from the bryozoan Amathia tortusa.

  Bioorganic & medicinal chemistry 20111115

• The pharmacological profile of brain liver intestine Na+ channel: inhibition by diarylamidines and activation by fenamates.

  Molecular pharmacology 20111101

• Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke.

  Experimental physiology 20111001

• Managing tsetse transmitted trypanosomosis by insecticide treated nets--an affordable and sustainable method for resource poor pig farmers in Ghana.

  PLoS neglected tropical diseases 20111001

• Genital lesions in male red fronted gazelles (Gazella rufifrons) experimentally infected with Trypanosoma brucei and the effect of melarsamine hydrochloride (Cymelarsan®) and diminazene aceturate (Berenil®) in its treatment.

  Theriogenology 20110901

• CBFB and MYH11 in inv(16)(p13q22) of acute myeloid leukemia displaying close spatial proximity in interphase nuclei of human hematopoietic stem cells.

  Genes, chromosomes & cancer 20110901

• Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities.

  The Biochemical journal 20110901

• Prediction of off-target effects on angiotensin-converting enzyme 2.

  Journal of biomolecular screening 20110901

• Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis.

  PLoS neglected tropical diseases 20110901

• Serial haematology results in transfused and non-transfused dogs naturally infected with Babesia rossi.

  Journal of the South African Veterinary Association 20110901

• Experimental infection with Rangelia vitalii in dogs: acute phase, parasitemia, biological cycle, clinical-pathological aspects and treatment.

  Experimental parasitology 20110801

• Polyamines in aging and disease.

  Aging 20110801

• Influence of trypanocidal therapy on the haematology of vervet monkeys experimentally infected with Trypanosoma brucei rhodesiense.

  Acta tropica 20110701

• Diminazene aceturate associated with sodium selenite and vitamin E in the treatment of Trypanosoma evansi infection in rats.

  Experimental parasitology 20110701

• The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes.

  Molecular pharmacology 20110701

• Improved PCR-RFLP for the detection of diminazene resistance in Trypanosoma congolense under field conditions using filter papers for sample storage.

  PLoS neglected tropical diseases 20110701

• Drug delivery systems in the treatment of African trypanosomiasis infections.

  Expert opinion on drug delivery 20110601

• SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.

  PLoS neglected tropical diseases 20110601

• Specific berenil-DNA interactions: an approach for separation of plasmid isoforms by pseudo-affinity chromatography.

  Analytical biochemistry 20110515

• Effect of topoisomerase inhibitors and DNA-binding drugs on the cell proliferation and ultrastructure of Trypanosoma cruzi.

  International journal of antimicrobial agents 20110501

• The effects of combination of methanolic leaf extract of Azadirachta indica and diminazene diaceturate in the treatment of experimental Trypanosoma brucei brucei infection in rats.

  Asian Pacific journal of tropical medicine 20110501

• Horses naturally infected by Trypanosoma vivax in southern Brazil.

  Parasitology research 20110101

• Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation.

  Bioorganic & medicinal chemistry 20110101

• Emergence of new types of Theileria orientalis in Australian cattle and possible cause of theileriosis outbreaks.

  Parasites & vectors 20110101

• Efficacy study of novel diamidine compounds in a Trypanosoma evansi goat model.

  PloS one 20110101

• Molecular and cellular characterization of an AT-hook protein from Leishmania.

  PloS one 20110101

• In vitro and in vivo antileishmanial efficacy of a combination therapy of diminazene and artesunate against Leishmania donovani in BALB/c mice.

  Revista do Instituto de Medicina Tropical de Sao Paulo 20110101

• Functional modifications of acid-sensing ion channels by ligand-gated chloride channels.

  PloS one 20110101

• Neglected disease - african sleeping sickness: recent synthetic and modeling advances.

  Scientia pharmaceutica 20110101

• Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones.

  Molecular biology international 20110101

• Gold nanoparticles in biology and medicine: recent advances and prospects.

  Acta naturae 20110101

• Development of a nanoparticulate formulation of diminazene to treat African trypanosomiasis.

  Nanotechnology 20101217

• Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor.

  The Journal of biological chemistry 20101210

• The killing of African trypanosomes by ethidium bromide.

  PLoS pathogens 20101201

• Reduced transcript levels of the heat shock protein 70 gene in diminazene aceturate-resistant Babesia gibsoni variants under low concentrations of diminazene aceturate.

  The Japanese journal of veterinary research 20101101

• Babesia canis and Babesia rossi co-infection in an untraveled Nigerian dog.

  Veterinary parasitology 20101029

• Chemosensitization of Trypanosoma congolense strains resistant to isometamidium chloride by tetracyclines and enrofloxacin.

  PLoS neglected tropical diseases 20100901

• Efficacy of Cymelarsan and Diminasan against Trypanosoma equiperdum infections in mice and horses.

  Veterinary parasitology 20100804

• Malaria gametocytogenesis.

  Molecular and biochemical parasitology 20100801

• Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif.

  Bioorganic & medicinal chemistry letters 20100801

• Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. I. Parasitological, hematological and pathological parameters.

  PLoS neglected tropical diseases 20100801

• DNA instability at chromosomal fragile sites in cancer.

  Current genomics 20100801

• Diarylamidines: high potency inhibitors of acid-sensing ion channels.

  Neuropharmacology 20100601

• Development and characterization of a strain of Babesia gibsoni resistant to diminazene aceturate in vitro.

  The Journal of veterinary medical science 20100601

• Structural binding evidence of the trypanocidal drugs berenil and pentacarinate active principles to a serine protease model.

  International journal of biological macromolecules 20100601

• In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi.

  Veterinary parasitology 20100511

• Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species.

  European journal of medicinal chemistry 20100301

• Frequency and therapy monitoring of canine Babesia spp. infection by high-resolution melting curve quantitative FRET-PCR.

  Veterinary parasitology 20100226

• Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives.

  Journal of medicinal chemistry 20100211

• Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes.

  Eukaryotic cell 20100201

• Evaluation of the in vitro growth-inhibitory effect of epoxomicin on Babesia parasites.

  Veterinary parasitology 20100120

• Characterization of major surface protease homologues of Trypanosoma congolense.

  Journal of biomedicine & biotechnology 20100101

• Immunobiology of African trypanosomes: need of alternative interventions.

  Journal of biomedicine & biotechnology 20100101

• Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging.

  Particle and fibre toxicology 20100101

• Proteomics of Trypanosoma evansi infection in rodents.

  PloS one 20100101

• Use of a doxycycline-enrofloxacin-metronidazole combination with/without diminazene diaceturate to treat naturally occurring canine babesiosis caused by Babesia gibsoni.

  Acta veterinaria Scandinavica 20100101

• Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia.

  PloS one 20100101

• Experiences with an in-training community service model in the control of zoonotic sleeping sickness in Uganda.

  Journal of veterinary medical education 20100101

• The effect of a novel dinuclear platinum complex with berenil and 2-picoline ligands on growth of human breast cancer cells.

  Acta poloniae pharmaceutica 20100101

• Senna occidentalis leaf extract possesses antitrypanosomal activity and ameliorates the trypanosome-induced anemia and organ damage.

  Pharmacognosy research 20100101

• The intravenous pharmacokinetics of diminazene in healthy dogs.

  Journal of the South African Veterinary Association 20091201

• The effects of hairpin loops on ligand-DNA interactions.

  The journal of physical chemistry. B 20091029

• Diminazene aceturate in the control of Trypanosoma evansi infection in cats.

  Veterinary parasitology 20091028

• Structure and inhibition of human diamine oxidase.

  Biochemistry 20091020

• Endemic type of animal trypanosomiasis is not associated with lower genotype variability of Trypanosoma congolense isolates circulating in livestock.

  Research in veterinary science 20091001

• Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.

  The American journal of tropical medicine and hygiene 20091001

• Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal.

  PLoS neglected tropical diseases 20090901

• Advancing drug innovation for neglected diseases-criteria for lead progression.

  PLoS neglected tropical diseases 20090801

• Effects of melarsamine hydrochloride (Cymelarsan) and diminazene aceturate (Berenil) on the pathology of experimental Trypanosoma brucei infection in red fronted gazelles (Gazella rufifrons).

  Veterinary parasitology 20090707

• Immunospecific immunoglobulins and IL-10 as markers for Trypanosoma brucei rhodesiense late stage disease in experimentally infected vervet monkeys.

  Tropical medicine & international health : TM & IH 20090701

• Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis.

  Brain : a journal of neurology 20090501

• Isolation of antibabesial compounds from Brucea javanica, Curcuma xanthorrhiza, and Excoecaria cochinchinensis.

  Bioscience, biotechnology, and biochemistry 20090323

• Evaluation of efficacy of bruceine A, a natural quassinoid compound extracted from a medicinal plant, Brucea javanica, for canine babesiosis.

  The Journal of veterinary medical science 20090101

• Canine babesiosis: from molecular taxonomy to control.

  Parasites & vectors 20090101

• Chemotherapy of human african trypanosomiasis.

  Interdisciplinary perspectives on infectious diseases 20090101

• A luciferase based viability assay for ATP detection in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.

  Parasites & vectors 20090101

• In vitro antitrypanosomal activities of quassinoid compounds from the fruits of a medicinal plant, Brucea javanica.

  Veterinary parasitology 20081220

• Pharmacophore based discovery of potential antimalarial agent targeting haem detoxification pathway.

  European journal of medicinal chemistry 20081201

• Five-fold increase in Trypanosoma congolense isolates resistant to diminazene aceturate over a seven-year period in Eastern Zambia.

  Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20081201

• The blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain.

  Journal of neurochemistry 20081101

• Preparation of polyclonal antibodies to diminazene and its detection in animal blood plasma.

  International immunopharmacology 20081001

• The promotion of secondary structures in single-stranded DNA by drugs that bind to duplex DNA: an atomic force microscopy study.

  Nanotechnology 20080924

• Estimation of tsetse challenge and its relationship with trypanosomosis incidence in cattle kept under pastoral production systems in Kenya.

  Veterinary parasitology 20080817

• Comparative efficacy of diminazene diaceturate and diminazene aceturate for the treatment of babesiosis in horses.

  Tropical animal health and production 20080801

• Enhancement of hydrophilic drug loading and release characteristics through micellization with new carboxymethyldextran-PEG block copolymers of tunable charge density.

  International journal of pharmaceutics 20080522

• Assessment of the occurrence of trypanocidal drug resistance in trypanosomes of naturally infected cattle in the Adamaoua region of Cameroon using the standard mouse test and molecular tools.

  Acta tropica 20080501

• Molecular tools for the rapid detection of drug resistance in animal trypanosomes.

  Trends in parasitology 20080501

• Prevalence of bovine trypanosomosis and trypanocidal drug sensitivity studies on Trypanosoma congolense in Wolyta and Dawero zones of southern Ethiopia.

  Veterinary parasitology 20080325

• Comparative efficacy assessment of pentamidine isethionate and diminazene aceturate in the chemotherapy of Trypanosoma brucei brucei infection in dogs.

  Veterinary parasitology 20080214

• Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.

  Journal of medicinal chemistry 20080214

• Acute phase response in mice experimentally infected with Trypanosoma congolense: a molecular gauge of parasite-host interaction.

  Veterinary parasitology 20080125

• Microarray analysis of the in vivo sequence preferences of a minor groove binding drug.

  BMC genomics 20080101

• DNA-binding activity and cytotoxicity of Pt-berenil compounds in MDA-MB-231 and MCF-7 breast cancer cells.

  Acta poloniae pharmaceutica 20080101

• Synthesis, DNA-binding affinity and cytotoxicity of the dinuclear platinum(II) complexes with berenil and amines ligands.

  Acta poloniae pharmaceutica 20080101

• A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum.

  BMC genomics 20080101

• Screening of Indonesian medicinal plant extracts for antibabesial activity and isolation of new quassinoids from Brucea javanica.

  Journal of natural products 20071001

• Heterogeneity in the trypanosomosis incidence in Zebu cattle of different ages and sex on the plateau of eastern Zambia.

  Acta tropica 20070801

• Clinical management of babesiosis in dogs with homeopathic Crotalus horridus 200C.

  Homeopathy : the journal of the Faculty of Homeopathy 20070401

• Anti-babesial compounds from Curcuma xanthorrhiza.

  Natural product research 20070401

• Molecular characterisation of Babesia gibsoni infection from a pit-bull terrier pup recently imported into South Africa.

  Journal of the South African Veterinary Association 20070301

• Occurrence of multiple drug resistance in Trypanosoma brucei rhodesiense isolated from sleeping sickness patients.

  The Onderstepoort journal of veterinary research 20070301

• The pathogenesis of anaemia in goats experimentally infected with Trypanosoma congolense or Trypanosoma brucei: use of the myeloid:erythroid ratio.

  Veterinary parasitology 20070227

• Rigid dipeptide mimics: synthesis of enantiopure C6-functionalized pyrrolizidinone amino acids.

  The Journal of organic chemistry 20070202

• Trypanosomiasis by Trypanosoma vivax in cattle in the Brazilian semiarid: Description of an outbreak and lesions in the nervous system.

  Veterinary parasitology 20070131

• Co-administration of Na-EDTA and diminazene aceturate (DA) to mice infected with DA-resistant Trypanosoma brucei.

  Journal of comparative pathology 20070101

• Genotypic and phenotypic characterization of Trypanosoma brucei gambiense isolates from Ibba, South Sudan, an area of high melarsoprol treatment failure rate.

  Acta tropica 20070101

• Combined contribution of TbAT1 and TbMRPA to drug resistance in Trypanosoma brucei.

  Molecular and biochemical parasitology 20061201

• Androgens differentially potentiate mouse intestinal smooth muscle by nongenomic activation of polyamine synthesis and Rho kinase activation.

  Endocrinology 20061201

• Fumagillin, a new P-glycoprotein-interfering agent able to modulate moxidectin efflux in rat hepatocytes.

  Journal of veterinary pharmacology and therapeutics 20061201

• Confirmation of diminazene diaceturate in bovine plasma using electrospray liquid chromatography-mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061121

• SSCP analysis of the P2 purine transporter TcoAT1 gene of Trypanosoma congolense leads to a simple PCR-RFLP test allowing the rapid identification of diminazene resistant stocks.

  Acta tropica 20061101

• Response of four indigenous cattle breeds to natural tsetse and trypanosomosis challenge in the Ghibe valley of Ethiopia.

  Veterinary parasitology 20061010

• Porcine eperythrozoonosis in China.

  Annals of the New York Academy of Sciences 20061001

• Equine trypanosomosis in the Central River Division of The Gambia: a study of veterinary gate-clinic consultation records.

  Preventive veterinary medicine 20060817

• Stability analysis for double-stranded DNA oligomers and their noncovalent complexes with drugs by laser spray.

  Journal of mass spectrometry : JMS 20060801

• Excitability scores of goats administered ascorbic acid and transported during hot-dry conditions.

  Journal of veterinary science 20060601

• Chemotherapy against babesiosis.

  Veterinary parasitology 20060531

• Epidemiology of Trypanosoma vivax infection in cattle in the tse-tse free area of Lake Chad.

  Preventive veterinary medicine 20060517

• Study on the susceptibility of Sahel goats to experimental Trypanosoma vivax infection.

  Veterinary parasitology 20060430

• Quantitative analysis of DNA-porphyrin interactions.

  Biopolymers 20060405

• Complexes of poly(ethylene oxide)-block-poly(L-glutamate) and diminazene.

  Langmuir : the ACS journal of surfaces and colloids 20060227

• Drug-resistance of Trypanosoma b. rhodesiense isolates from Tanzania.

  Tropical medicine & international health : TM & IH 20060201

• Leishmania donovani: differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays.

  Experimental parasitology 20060101

• A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats.

  Parasitology 20060101

• RNA aptamers as potential pharmaceuticals against infections with African trypanosomes.

  Handbook of experimental pharmacology 20060101

• The effectivity analysis of accumulation of liposomal, micellar, and water-soluble forms of diminazene in cells and in organs.

  Drug delivery 20060101

• In vitro growth inhibition of bloodstream forms of Trypanosoma brucei and Trypanosoma congolense by iron chelators.

  Kinetoplastid biology and disease 20060101

• Comparative application of wavelet approaches to absorption and ratio spectra for the simultaneous determination of diminazene aceturate and phenazone in veterinary granules for injection.

  Die Pharmazie 20051201

• The susceptibility of Trypanosoma congolense isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride.

  The Onderstepoort journal of veterinary research 20051201

• Acquired resistance to berenil in a cloned isolate of Trypanosoma evansi is associated with upregulation of a novel gene, TeDR40.

  Parasitology 20051101

• Thermodynamic evaluation and modeling of proton and water exchange associated with benzamidine and berenil binding to beta-trypsin.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20051101

• Diminazene aceturate resistance on the virulence of Trypanosoma brucei for rats.

  Journal of comparative pathology 20051101

• The pharmacokinetics of diminazene aceturate after intramuscular administration in healthy dogs.

  Journal of the South African Veterinary Association 20050901

• Synthesis of a novel PEG-block-poly(aspartic acid-stat-phenylalanine) copolymer shows potential for formation of a micellar drug carrier.

  International journal of pharmaceutics 20050613

• Susceptibility of West African Dwarf goats and WAD x Saanen crosses to experimental infection with Trypanosoma congolense.

  Veterinary parasitology 20050610

• Identification of anti-babesial activity for four ethnoveterinary plants in vitro.

  Veterinary parasitology 20050610

• Anti-babesial compounds from Curcuma zedoaria.

  Planta medica 20050501

• Semicarbazide-functionalized Si(111) surfaces for the site-specific immobilization of peptides.

  Langmuir : the ACS journal of surfaces and colloids 20050215

• Exotic diseases of dogs and cats at risk of importation to Ireland.

  Irish veterinary journal 20050101

• Transition models to assess risk factors for new and persistent trypanosome infections in cattle-analysis of longitudinal data from the Ghibe Valley, southwest Ethiopia.

  The Journal of parasitology 20041201

• Knowledge and attitudes of cattle owners regarding trypanosomosis control in tsetse-infested areas of Uganda.

  Journal of the South African Veterinary Association 20041201

• Analysis of GAA/TTC DNA triplexes using nuclear magnetic resonance and electrospray ionization mass spectrometry.

  Analytical biochemistry 20041115

• Degradation of berenil (diminazene aceturate) in acidic aqueous solution.

  The Journal of pharmacy and pharmacology 20041001

• Trypanocidal failure suggested by PCR results in cattle field samples.

  Acta tropica 20040901

• Protective efficacy of isometamidium chloride and diminazene aceturate against natural Trypanosoma brucei, Trypanosoma congolense and Trypanosoma vivax infections in cattle under a suppressed tsetse population in Uganda.

  The Onderstepoort journal of veterinary research 20040901

• DNA minor groove binders as potential antitumor and antimicrobial agents.

  Medicinal research reviews 20040701

• Micronuclei induced by aneugens and clastogens in mononucleate and binucleate cells using the cytokinesis block assay.

  Mutagenesis 20040701

• Effect of diminazene block treatment on live redwater vaccine reactions.

  The Onderstepoort journal of veterinary research 20040601

• Lipid-drug conjugate nanoparticles of the hydrophilic drug diminazene-cytotoxicity testing and mouse serum adsorption.

  Journal of controlled release : official journal of the Controlled Release Society 20040518

• Bloodstream form-specific up-regulation of silent vsg expression sites and procyclin in Trypanosoma brucei after inhibition of DNA synthesis or DNA damage.

  The Journal of biological chemistry 20040402

• Application of field methods to assess isometamidium resistance of trypanosomes in cattle in western Ethiopia.

  Acta tropica 20040401

• Characterization of a novel DNA minor-groove complex.

  Biophysical journal 20040201

• Trypanocidal drug resistance in eastern province of Zambia.

  Veterinary parasitology 20040130

• The effects of diminazene aceturate and ceftriaxone on ram sperm.

  Theriogenology 20040115

• A large-scale trial to evaluate the efficacy of a 1% pour-on formulation of cyfluthrin (Cylence, Bayer) in controlling bovine trypanosomosis in Eastern Zambia.

  Tropical animal health and production 20040101

• RNA-interference silencing of the adenosine transporter-1 gene in Trypanosoma evansi confers resistance to diminazene aceturate.

  Experimental parasitology 20040101

• Gametocytogenesis: the puberty of Plasmodium falciparum.

  Malaria journal 20040101

• Efficacy of combined atovaquone and azithromycin for therapy of chronic Babesia gibsoni (Asian genotype) infections in dogs.

  Journal of veterinary internal medicine 20040101

• Efficacy of Trypan: a diminazene based drug as antileishmanial agent.

  Acta tropica 20040101

• The effect of inducing agents on the metabolism of trypanocidal diamidines by isolated rat hepatocytes.

  Chemico-biological interactions 20031215

• Changes in adenosine transport associated with melaminophenyl arsenical (Mel CY) resistance in Trypanosoma evansi: down-regulation and affinity changes of the P2 transporter.

  Parasitology 20031201

• The leucocytic and parasitaemic profiles and immune response of rats treated with retinyl palmitate before infection with Trypanosoma brucei.

  Journal of comparative pathology 20031101

• Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.

  Eukaryotic cell 20031001

• The effects of diminazene aceturate on systemic blood pressure in clinically healthy adult dogs.

  Journal of the South African Veterinary Association 20030901

• Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice.

  Brain : a journal of neurology 20030701

• Field studies of drug-resistant cattle trypanosomes in Kénédougou Province, Burkina Faso.

  Acta tropica 20030401

• Intra-uterine Infection with Babesia bovis in a 2-day-old Calf.

  Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20030301

• Chemotherapy of surra in horses and mules with diminazene aceturate.

  Veterinary parasitology 20030102

• The pathogenicity of diminazene aceturate-resistant Trypanosoma brucei in rats after treatment with the drug.

  Journal of comparative pathology 20030101

• The rare human fragile site 16B.

  Cytogenetic and genome research 20030101

• Liquid chromatographic determination of diminazene diaceturate (Berenil) in raw bovine milk.

  Journal of AOAC International 20030101

• Electron paramagnetic resonance dynamic signatures of TAR RNA-small molecule complexes provide insight into RNA structure and recognition.

  Biochemistry 20021217

• Determination of diminazene aceturate in pharmaceutical formulations by HPLC and identification of related substances by LC/MS.

  Journal of pharmaceutical and biomedical analysis 20021107

• A competitive enzyme-linked immunosorbent assay for diminazene.

  Acta tropica 20021101

• Financial implications of rearing sheep and goats under natural trypanosomosis challenge at Galana ranch, Kenya.

  Tropical animal health and production 20021101

• Residual effect of antibabesial drugs on the live redwater blood vaccines.

  Annals of the New York Academy of Sciences 20021001

• Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda.

  Acta tropica 20021001

• Lipid-drug-conjugate (LDC) nanoparticles as novel carrier system for the hydrophilic antitrypanosomal drug diminazenediaceturate.

  Journal of drug targeting 20020801

• In vitro cultivation of Chinese strains of Babesia spp.

  Parasitology research 20020501

• Developments in the treatment of leishmaniasis and trypanosomiasis.

  Expert opinion on emerging drugs 20020501

• Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei.

  International journal of antimicrobial agents 20020301

• Inhibition of DNA replication by berenil in plasmids containing Poly(dA)poly(dT) sequences.

  Plasmid 20020301

• S-adenosylmethionine decarboxylase from Leishmania donovani. Molecular, genetic, and biochemical characterization of null mutants and overproducers.

  The Journal of biological chemistry 20020222

• Effect of strand orientation on the interaction of berenil with DNA triple helices.

  European biophysics journal : EBJ 20020201

• Discriminating small molecule DNA binding modes by single molecule force spectroscopy.

  FEBS letters 20020116

• Inhibition of DNA replication by berenil of bacterial plasmids containing poly(dA)-poly(dT) sequences. 2D gel analysis of replicative intermediates.

  Cellular and molecular biology (Noisy-le-Grand, France) 20020101

• Changes in properties of adenosine transporters in Trypanosoma evansi and modes of selection of resistance to the melaminophenyl arsenical drug, Mel Cy.

  Veterinary parasitology 20011213

• Enhancing effects of anti-CD40 treatment on the immune response of SCID-bovine mice to Trypanosoma congolense infection.

  Journal of leukocyte biology 20011201

• In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense.

  Planta medica 20011001

• Drug-resistant Trypanosoma congolense in naturally infected donkeys in north Omo Zone, southern Ethiopia.

  Veterinary parasitology 20010831

• Drug-polyionic block copolymer interactions for micelle formation: physicochemical characterisation.

  Journal of controlled release : official journal of the Controlled Release Society 20010810

• Bioassay-guided studies on the cytotoxic and in vitro trypanocidal activities of a sesquiterpene (Muzigadial) derived from a Ugandan medicinal plant (Warburgia ugandensis).

  African health sciences 20010801

• Heterogeneous DNA binding modes of berenil.

  Biochimica et biophysica acta 20010628

• A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity.

  Journal of the American Chemical Society 20010627

• Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle.

  Veterinary parasitology 20010612

• Concentration-dependent inhibition of sheep erythrocyte ghost plasma membrane Ca2+-ATPase activity by Berenil.

  Journal of veterinary pharmacology and therapeutics 20010601

• DNA minor-groove recognition by small molecules.

  Natural product reports 20010601

• The incidence of new and the prevalence and persistence of recurrent trypanosome infections in cattle in southwest Ethiopia exposed to a high challenge with drug-resistant parasites.

  Acta tropica 20010525

• A comparative evaluation of parasitological tests and a PCR for Trypanosoma evansi diagnosis in experimentally infected water buffaloes.

  Veterinary parasitology 20010509

• Transporters in African trypanosomes: role in drug action and resistance.

  International journal for parasitology 20010501

• Effect of clindamycin therapy on phagocytic and oxidative activity profiles of spleen mononuclear cells in Babesia rodhaini-infected mice.

  The Journal of veterinary medical science 20010501

• Validation of a polymerase chain reaction assay for monitoring the therapeutic efficacy of diminazene aceturate in trypanosome-infected sheep.

  Veterinary parasitology 20010320

• Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals.

  Molecular pharmacology 20010301

• Cytokines and the acute phase response in post-treatment reactive encephalopathy of Trypanosoma brucei brucei infected mice.

  Parasitology international 20010301

• Enhanced lipid peroxide levels in the erythrocytes of calves with haemoglobinuria.

  Veterinary research communications 20010101

• In vitro effect of diamidines on intracellular polyamines of Acanthamoeba polyphaga.

  Drugs under experimental and clinical research 20010101

• Highly potent synthetic polyamides, bisdistamycins, and lexitropsins as inhibitors of human immunodeficiency virus type 1 integrase.

  Molecular pharmacology 19980801

• Linked lexitropsins and the in vitro inhibition of HIV-1 reverse transcriptase RNA-directed DNA polymerization: a novel induced-fit of 3,5 m-pyridyl bisdistamycin to enzyme-associated template-primer.

  Biochemistry 19961203

• Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.

  Annals of tropical medicine and parasitology 19961201

• New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.

  Journal of medicinal chemistry 19951124

• DNA-binding activity and biological effects of aromatic polyamidines.

  Biochemical pharmacology 19940211

• Efficacy of DL-alpha-difluoromethylornithine in a rat model of Pneumocystis carinii pneumonia.

  Antimicrobial agents and chemotherapy 19880801

• Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia.

  Antimicrobial agents and chemotherapy 19880601

• Antifungal and antibacterial activities of diarylamidine derivatives.

  Antimicrobial agents and chemotherapy 19800801