-
Spinal blockades of class I antiarrythmic drugs with bupivacaine by isobolographic analysis in rats.
Neuroscience letters 20121018
-
Mexiletine for symptoms and signs of myotonia in nondystrophic myotonia: a randomized controlled trial.
JAMA 20121003
-
Mexiletine for treatment of myotonia: a trial triumph for rare disease networks.
JAMA 20121003
-
Primary erythromelalgia in a 12-year-old boy: positive response to sodium channel blockers despite negative SCN9A mutations.
Klinische Padiatrie 20120901
-
Oxidative stress in the in vivo DMBA rat model of breast cancer: suppression by a voltage-gated sodium channel inhibitor (RS100642).
Basic & clinical pharmacology & toxicology 20120801
-
Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia.
The Journal of pharmacology and experimental therapeutics 20120701
-
Biophysical characterization of M1476I, a sodium channel founder mutation associated with cold-induced myotonia in French Canadians.
The Journal of physiology 20120601
-
Voltage-gated Na+ channel blockers reduce functional bladder capacity in the conscious spontaneously hypertensive rat.
Urology 20120601
-
Enantioselective drug-protein interaction between mexiletine and plasma protein.
The Journal of pharmacy and pharmacology 20120601
-
Stereoselective binding of mexiletine and ketoprofen enantiomers with human serum albumin domains.
Acta pharmacologica Sinica 20120501
-
Asymmetric hydrolytic kinetic resolution with recyclable macrocyclic Co(III)-salen complexes: a practical strategy in the preparation of (R)-mexiletine and (S)-propranolol.
Chemistry (Weinheim an der Bergstrasse, Germany) 20120423
-
Wide QRS Tachycardia in a young patient.
Archives of internal medicine 20120409
-
Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels.
Journal of medicinal chemistry 20120209
-
Drug-induced hypersensitivity syndrome followed by persistent arthritis.
The Journal of dermatology 20120201
-
High-dose intravenous immunoglobulin monotherapy for drug-induced hypersensitivity syndrome.
Acta dermato-venereologica 20120101
-
Cardioprotective effects of sarcolemmal and mitochondrial K-ATP channel openers in an experimental model of autoimmune myocarditis. Role of the reduction in calcium overload during acute heart failure.
International heart journal 20120101
-
Long QT syndrome with nocturnal cardiac events caused by a KCNH2 missense mutation (G604S).
Internal medicine (Tokyo, Japan) 20120101
-
Bisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channel.
PloS one 20120101
-
Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks.
Pacing and clinical electrophysiology : PACE 20111201
-
Hemodialysis as an alternative treatment of mexiletine intoxication.
The American journal of emergency medicine 20111101
-
Enantiomeric purity of chiral derivatizing reagents for enantioresolution.
Bioanalysis 20110901
-
Indirect enantioresolution of (R,S)-mexiletine by reversed-phase high-performance liquid chromatography via diastereomerization with [(S,S)-O,O'-di-p-toluoyl tartaric acid anhydride], (S)-naproxen and nine chiral reagents synthesized as variants of Marfey's reagent.
Biomedical chromatography : BMC 20110301
-
High performance liquid chromatography enantioseparation of the novel designed mexiletine derivatives and its analogs.
Chirality 20110201
-
Mexiletine is an effective antimyotonia treatment in myotonic dystrophy type 1.
Neurology 20110125
-
Functional atrioventricular conduction block in an elderly patient with acquired long QT syndrome: elucidation of the mechanism of block.
Journal of electrocardiology 20110101
-
Refractory erythromelalgia of the ears: response to mexiletine.
American journal of otolaryngology 20110101
-
Translation of flecainide- and mexiletine-induced cardiac sodium channel inhibition and ventricular conduction slowing from nonclinical models to clinical.
Journal of pharmacological and toxicological methods 20110101
-
Highly sensitive determination and validation of gabapentin in pharmaceutical preparations by HPLC with 4-fluoro-7-nitrobenzofurazan derivatization and fluorescence detection.
Journal of chromatographic science 20110101
-
Reversed-phase high-performance liquid chromatographic separation of diastereomers of (R,S)-mexiletine prepared by microwave irradiation with four new chiral derivatizing reagents based on trichloro-s-triazine having amino acids as chiral auxiliaries and 10 others having amino acid amides.
Journal of chromatography. A 20101203
-
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug metabolism and disposition: the biological fate of chemicals 20101201
-
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 20101101
-
Combination therapy with mexiletine and sotalol suppresses inherited ventricular arrhythmias in German shepherd dogs better than mexiletine or sotalol monotherapy: a randomized cross-over study.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 20100801
-
Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.
British journal of pharmacology 20100701
-
Congenital long QT syndrome and 2:1 atrioventricular block: an optimistic outcome in the current era.
Heart rhythm 20100601
-
Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity.
Archiv der Pharmazie 20100601
-
Mexiletine is an effective antimyotonia treatment in myotonic dystrophy type 1.
Neurology 20100504
-
Neuroprotective effects of mexiletine on motor evoked potentials in demyelinated rat spinal cords.
Neuroscience research 20100501
-
Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20100501
-
Trafficking defects and gating abnormalities of a novel SCN5A mutation question gene-specific therapy in long QT syndrome type 3.
Circulation research 20100430
-
Intravenous lidocaine and mexiletine in the management of trigeminal autonomic cephalalgias.
Current pain and headache reports 20100401
-
Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs.
Chirality 20100301
-
Effects of mexiletine, a CYP1A2 inhibitor, on tizanidine pharmacokinetics and pharmacodynamics.
Journal of clinical pharmacology 20100301
-
Neonatal long QT syndrome type 3 predicted by positive lidocaine challenge.
Pacing and clinical electrophysiology : PACE 20100301
-
Polymyositis presenting with cardiac manifestations: Report of two cases and review of the literature.
Clinical neurology and neurosurgery 20100201
-
Fabrication and evaluation of chiral monolithic column modified by beta-cyclodextrin derivatives.
Talanta 20100115
-
A case of mexiletine-induced hypersensitivity syndrome presenting as eosinophilic pneumonia.
Journal of Korean medical science 20100101
-
Comparison of the effect of mexiletine and methylprednisolone on neural function and histopathological damage after transient spinal cord ischemia in rabbits.
Turkish neurosurgery 20100101
-
Mexiletine reverses oxaliplatin-induced neuropathic pain in rats.
Journal of pharmacological sciences 20100101
-
Assessing use-dependent inhibition of the cardiac Na(+/-) current (I(Na)) in the PatchXpress automated patch clamp.
Journal of pharmacological and toxicological methods 20100101
-
Validated HPTLC methods for quantification of mexiletine hydrochloride in a pharmaceutical formulation.
Journal of AOAC International 20100101
-
Column-switching HPLC determination of mexiletine using tris(bipyridine)ruthenium(III) electrogenerated chemiluminescence and precolumn derivatization with divinylsulfone.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20100101
-
Deracemization of mexiletine biocatalyzed by omega-transaminases.
Organic letters 20091105
-
Design and assessment of a potent sodium channel blocking derivative of mexiletine for minimizing experimental neuropathic pain in several rat models.
Neurochemical research 20091001
-
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nature chemical biology 20091001
-
The preventive effect of mexiletine on cerebral ischemic injury following experimental middle cerebral artery occlusion.
Turkish neurosurgery 20091001
-
Synthesis of dinitrophenyl-L-Pro-N-hydroxysuccinimide ester and four new variants of Sanger's reagent having chiral amines and their application for enantioresolution of mexiletine using reversed-phase high-performance liquid chromatography.
Journal of chromatography. A 20090724
-
Enantioselective determination of mexiletine and its metabolites p-hydroxymexiletine and hydroxymethylmexiletine in rat plasma by normal-phase liquid chromatography-tandem mass spectrometry: application to pharmacokinetics.
Chirality 20090701
-
Mexiletine and lidocaine suppress the excitability of dorsal horn neurons.
Anesthesia and analgesia 20090701
-
Effect of mexiletine on dynamic allodynia induced by chronic constriction injury of the sciatic nerve in rats.
The Journal of veterinary medical science 20090701
-
A case of myotonic dystrophy presenting with ventricular tachycardia and atrial fibrillation.
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20090701
-
2D- and 3D-QSAR of tocainide and mexiletine analogues acting as Na(v)1.4 channel blockers.
European journal of medicinal chemistry 20090401
-
Mexiletine-responsive erythromelalgia due to a new Na(v)1.7 mutation showing use-dependent current fall-off.
Experimental neurology 20090401
-
Intravenous lidocaine infusion for the treatment of post-acoustic neuroma resection headache: a case report.
Headache 20090201
-
Evaluation of pressor and visceromotor reflex responses to bladder distension in urethane anesthetized rats.
Neurourology and urodynamics 20090101
-
Experience with oral mexiletine in primary erythromelalgia in children.
Annals of Saudi medicine 20090101
-
Novel automated assay for the quality control of mexiletine hydrochloride formulations using sequential injection and on-line dilution.
Journal of pharmaceutical and biomedical analysis 20081201
-
Malignant perinatal variant of long-QT syndrome caused by a profoundly dysfunctional cardiac sodium channel.
Circulation. Arrhythmia and electrophysiology 20081201
-
A practical and efficient route for the highly enantioselective synthesis of mexiletine analogues and novel beta-thiophenoxy and pyridyl ethers.
The Journal of organic chemistry 20080905
-
One from column A and one from column B: may I take your order?
Anesthesiology 20080801
-
Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial.
Anesthesiology 20080801
-
Studies on somnolence in the daytime caused by drugs used for neuropathic pain.
Journal of pharmacological sciences 20080701
-
[Central and peripheral mechanisms in antinociception: current and future perspectives].
Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20080601
-
Development and validation of HPLC method for the resolution of drug intermediates: DL-3-Phenyllactic acid, DL-O-acetyl-3-phenyllactic acid and (+/-)-mexiletine acetamide enantiomers.
Talanta 20080315
-
Mexiletine therapy for chronic pain: survival analysis identifies factors predicting clinical success.
Journal of pain and symptom management 20080301
-
Suppression of atrial fibrillation with mexiletine pharmacotherapy in a young woman with type 1 long QT syndrome.
Heart rhythm 20080301
-
Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries.
Behavioural pharmacology 20080201
-
Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator.
Journal of medicinal chemistry 20080124
-
Pharmacologic evaluation of pressor and visceromotor reflex responses to bladder distension.
Neurourology and urodynamics 20080101
-
Selective and stability-indicating methods for the simultaneous determination of mexiletine hydrochloride and/or its related substance: 2,6-dimethylphenol.
Journal of AOAC International 20080101
-
Experimental studies of potential analgesics for the treatment of chemotherapy-evoked painful peripheral neuropathies.
Pain medicine (Malden, Mass.) 20080101
-
Mexiletine for refractory chronic daily headache: a report of nine cases.
Headache 20080101
-
[Determination of mexiletine in human blood by liquid chromatography-tandem mass spectrometry].
Fa yi xue za zhi 20071201
-
Pharmacokinetic study of three cardiovascular drugs by high-performance liquid chromatography using pre-column derivatization with 9,10-anthraquinone-2-sulfonyl chloride.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015
-
The effects of Na movement on surgical myocardial protection: the role of the Na+-H+ exchange system and Na-channel in the development of ischemia and reperfusion injury.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20071001
-
Gating properties of SCN5A mutations and the response to mexiletine in long-QT syndrome type 3 patients.
Circulation 20070904
-
Differential contribution of sodium channel subtypes to action potential generation in unmyelinated human C-type nerve fibers.
Anesthesiology 20070901
-
Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20070701
-
Burning mouth syndrome: will better understanding yield better management?
Pain practice : the official journal of World Institute of Pain 20070601
-
Attenuation of microtubule associated protein-2 degradation after mild head injury by mexiletine and calpain-2 inhibitor.
British journal of neurosurgery 20070601
-
Ventricular ectopy during REM sleep: implications for nocturnal sudden cardiac death.
Nature clinical practice. Cardiovascular medicine 20070501
-
A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents.
Journal of cardiovascular electrophysiology 20070401
-
The cutaneous analgesic effect of class I antiarrhythmic drugs.
Anesthesia and analgesia 20070401
-
Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography--tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070301
-
S,S,S-Tris(2-ethylhexyl) phosphorotrithioate as an effective solvent mediator for a mexiletine-sensitive membrane electrode.
Analytical and bioanalytical chemistry 20070301
-
Intravenous lidocaine for neuropathic pain: diagnostic utility and therapeutic efficacy.
Current pain and headache reports 20070201
-
Optical mapping of ventricular arrhythmias in LQTS mice with SCN5A mutation N1325S.
Biochemical and biophysical research communications 20070126
-
Simultaneous separation of 14 antiarrhythmic drugs and determination of mexiletine and flecainide by capillary zone electrophoresis.
Journal of AOAC International 20070101
-
The effect of intravenously administered mexiletine on tinnitus - a pilot study.
International journal of audiology 20061201
-
The effect of mexiletine on the level of lipid peroxidation and apoptosis of endothelium following experimental subarachnoid hemorrhage.
Neurological research 20061201
-
Effect of congestive heart failure on mexiletine pharmacokinetics in a Japanese population.
Biological & pharmaceutical bulletin 20061101
-
Partial expression defect for the SCN5A missense mutation G1406R depends on splice variant background Q1077 and rescue by mexiletine.
American journal of physiology. Heart and circulatory physiology 20061001
-
Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents.
British journal of pharmacology 20061001
-
Acetazolamide acts directly on the human skeletal muscle chloride channel.
Muscle & nerve 20060901
-
Evaluation of patients with paramyotonia at 23Na MR imaging during cold-induced weakness.
Radiology 20060801
-
Successful parental use of an automated external defibrillator for an infant with long-QT syndrome.
Pediatrics 20060801
-
Systemic lidocaine or mexiletine for neuropathic pain.
American family physician 20060701
-
Myotonia congenita--a cause of muscle weakness and stiffness.
Nature clinical practice. Neurology 20060701
-
Neuroprotective effect of mexiletine in the central nervous system of diabetic rats.
Molecular and cellular biochemistry 20060601
-
Potent analgesic effects of a putative sodium channel blocker M58373 on formalin-induced and neuropathic pain in rats.
European journal of pharmacology 20060501
-
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
-
Catalytic roles of CYP2D6.10 and CYP2D6.36 enzymes in mexiletine metabolism: in vitro functional analysis of recombinant proteins expressed in Saccharomyces cerevisiae.
Biochemical pharmacology 20060428
-
Effect of mexiletine on vincristine-induced painful neuropathy in mice.
European journal of pharmacology 20060424
-
Comparison of the effects of four Na+ channel analgesics on TTX-resistant Na+ currents in rat sensory neurons and recombinant Nav1.2 channels.
Neuroscience letters 20060313
-
[An uncommon cause of recurrent abdominal pain in a 63-year-old obese woman].
Deutsche medizinische Wochenschrift (1946) 20060303
-
Class Ic antiarrhythmics block human skeletal muscle Na channel during myotonia-like stimulation.
European journal of pharmacology 20060217
-
A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y.
The Journal of clinical investigation 20060201
-
Influence of mexiletine on action potential discharge and conduction in nodose Adelta afferent neurons innervating guinea pig isolated trachea.
Pulmonary pharmacology & therapeutics 20060101
-
Digoxin and mexiletine sensitivity in a Collie with the MDR1 mutation.
Journal of veterinary internal medicine 20060101
-
Effects of mexiletine on electrical field stimulation-induced contractile responses in the ipsilateral and contralateral vasa deferentia after unilateral testicular torsion/detorsion.
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20060101
-
Drug-induced hypersensitivity syndrome due to mexiletine hydrochloride associated with reactivation of human herpesvirus 7.
Dermatology (Basel, Switzerland) 20060101
-
Analysis of human Nav1.8 expressed in SH-SY5Y neuroblastoma cells.
European journal of pharmacology 20051228
-
The effect of stationary phase on lipophilicity determination of beta-blockers using reverse-phase chromatographic systems.
Biomedical chromatography : BMC 20051201
-
Systemic administration of local anesthetics to relieve neuropathic pain: a systematic review and meta-analysis.
Anesthesia and analgesia 20051201
-
Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice.
Journal of cardiovascular electrophysiology 20051201
-
Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs.
Pain 20051101
-
Systemic administration of local anesthetic agents to relieve neuropathic pain.
The Cochrane database of systematic reviews 20051019
-
Double-blind, placebo-controlled pilot study of mexiletine for acute mania or hypomania.
Journal of clinical psychopharmacology 20051001
-
Drug therapy in Brugada syndrome.
Current drug targets. Cardiovascular & haematological disorders 20051001
-
Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats.
Pain 20050901
-
Prevention of ventricular extrasystole by mexiletine in patients with normal QT intervals is associated with a reduction of transmural dispersion of repolarization.
International journal of cardiology 20050803
-
Mexiletine treatment-induced inhibition of caspase-3 activation and improvement of behavioral recovery after spinal cord injury.
Journal of neurosurgery. Spine 20050701
-
[Symptomatic treatment of painful diabetic neuropathy].
Nihon rinsho. Japanese journal of clinical medicine 20050601
-
Inhibitory effects of psychotropic drugs on mexiletine metabolism in human liver microsomes: prediction of in vivo drug interactions.
Xenobiotica; the fate of foreign compounds in biological systems 20050601
-
Effect of sodium channel blocker (mexiletine) on pathological ectopic firing pattern in a rat chronic constriction nerve injury model.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20050501
-
Primary erythromelalgia in a child responding to intravenous lidocaine and oral mexiletine treatment.
Pediatrics 20050401
-
Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain.
Bioorganic & medicinal chemistry letters 20050401
-
Drug-induced hypersensitivity syndrome due to mexiletine associated with human herpes virus 6 and cytomegalovirus reactivation.
The Journal of dermatology 20050401
-
Preferred mexiletine block of human sodium channels with IVS4 mutations and its pH-dependence.
Pharmacogenetics and genomics 20050401
-
Fiction: the Christmas card.
Neurology 20050308
-
Systemic lidocaine and mexiletine for the treatment of a patient with total ulcerative colitis.
Gut 20050301
-
Inhibitory effects of lidocaine and mexiletine on vasorelaxation mediated by adenosine triphosphate-sensitive K+ channels and the role of kinases in the porcine coronary artery.
Anesthesiology 20050301
-
A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor.
Molecular pharmacology 20050201
-
The effects of mexiletine on excitability properties of human median motor axons.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20050201
-
Mexiletine protects myocardium during acute ischemia by opening sarcolemmal K-ATP channel: studies in closed-chest acute ischemia model in rabbits.
Journal of cardiovascular pharmacology 20041201
-
Effect of mexiletine on fenvalerate-induced nociceptive response in diabetic mice.
Journal of pharmacological sciences 20041101
-
[The filter region of the myocardial Na channel, together with ion selectivity, controls pharmacodynamics of anti-arrhythmia agents--an analysis using the channel altered by idiopathic ventricular fibrillation].
[Hokkaido igaku zasshi] The Hokkaido journal of medical science 20041101
-
A case of fulminant Type 1 diabetes associated with mexiletine hypersensitivity syndrome.
Diabetic medicine : a journal of the British Diabetic Association 20041001
-
Effects of ciprofloxacin on the stereoselective disposition of mexiletine in man.
Therapeutic drug monitoring 20041001
-
Enantiomeric separation of basic drugs with partially filled serum albumin as chiral selector in capillary electrophoresis.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20041001
-
A case of primary erythromelalgia improved by mexiletine.
The British journal of dermatology 20040901
-
Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access.
Molecular pharmacology 20040801
-
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse.
Neuromuscular disorders : NMD 20040701
-
Rate-dependent QRS prolongation during exercise testing associated with hyperkalemia.
Journal of electrocardiology 20040701
-
Early effects of mild brain trauma on the cytoskeletal proteins neurofilament160 and MAP2, and the preventive effects of mexilitine.
Acta neurochirurgica 20040601
-
Images in cardiovascular medicine. Life-threatening neonatal arrhythmia: successful treatment and confirmation of clinically suspected extreme long QT-syndrome-3.
Circulation 20040511
-
Effects of antiarrhythmic agents on left ventricular function during exercise in patients with chronic left ventricular dysfunction.
Annals of nuclear medicine 20040501
-
A trafficking defective, Brugada syndrome-causing SCN5A mutation rescued by drugs.
Cardiovascular research 20040401
-
Characterization of mexiletine as an antagonist of beta-adrenoceptor in Chinese hamster ovary cells expressing cloned human beta-adrenoceptors.
Biochemical pharmacology 20040301
-
Frequent ventricular extrasystole treated by needling neiguan (PC 6) plus oral administration of mexiletine--a report of 30 cases.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20040301
-
Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na+ channels.
The Journal of physiology 20040201
-
Stereospecific synthesis of 'para-hydroxymexiletine' and sodium channel blocking activity evaluation.
Chirality 20040201
-
Systemic lidocaine in pain due to peripheral nerve injury and predictors of response.
Neurology 20040127
-
Novel antiarrhythmic compounds with combined class IB and class III mode of action.
Current medicinal chemistry 20040101
-
Oxcarbazepine antinociception in animals with inflammatory pain or painful diabetic neuropathy.
Clinical and experimental pharmacology & physiology 20040101
-
Inactivation-deficient human skeletal muscle Na+ channels (hNav1.4-L443C/A444W) in stably transfected HEK-293 cells.
Receptors & channels 20040101
-
Comparison of classical and derivative UV-spectrophotometric methods for the quantification of diltiazem and mexiletine.
Acta poloniae pharmaceutica 20040101
-
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels.
Journal of medicinal chemistry 20031120
-
Akt activation induced by an antioxidant compound during ischemia-reperfusion.
Free radical biology & medicine 20031101
-
Effects of mexiletine, ginkgo biloba extract (EGb 761), and their combination on experimental head injury.
Neurosurgical review 20031001
-
Attenuating effect of mexiletine hydrochloride on herpetic pain in mice infected with herpes simplex virus.
The Journal of pharmacy and pharmacology 20031001
-
Impact of CYP2D6*10 on mexiletine pharmacokinetics in healthy adult volunteers.
European journal of clinical pharmacology 20030901
-
Effects of mexiletine on the canine model of sparfloxacin-induced long QT syndrome.
European journal of pharmacology 20030822
-
Nifekalant hydrochloride, a novel class III antiarrhythmic agent, suppressed postoperative recurrent ventricular tachycardia in a patient undergoing coronary artery bypass grafting and the Dor approach.
Circulation journal : official journal of the Japanese Circulation Society 20030801
-
Mexiletine carbonyloxy beta-D-glucuronide: a novel metabolite in human urine.
Xenobiotica; the fate of foreign compounds in biological systems 20030801
-
Development of enzyme-linked immunosorbent assay for therapeutic drug monitoring of mexiletine.
Biological & pharmaceutical bulletin 20030601
-
Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment.
Brain : a journal of neurology 20030401
-
Effect of mexiletine on long QT syndrome model.
Acta pharmacologica Sinica 20030401
-
[Treatment of familial erythermalgia with the association of lidocaine and mexiletine].
Annales de dermatologie et de venereologie 20030401
-
Mexiletine inhibits nonadrenergic noncholinergic lower oesophageal sphincter relaxation in rabbits.
European journal of pharmacology 20030328
-
Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice.
Cardiovascular research 20030315
-
Mexiletine differentially modulates vasorelaxation mediated by adenosine triphosphate-sensitive K+ channels in aortas from normotensive and hypertensive rats.
Anesthesia and analgesia 20030301
-
Ventricular tachyarrhythmias in a canine model of LQT3: arrhythmogenic effects of sympathetic activity and therapeutic effects of mexiletine.
Circulation journal : official journal of the Japanese Circulation Society 20030301
-
Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile.
Naunyn-Schmiedeberg's archives of pharmacology 20030301
-
[HPLC-fluorescent spectrometric determination of serum mexiletine concentration after derivatization with fluram].
Yao xue xue bao = Acta pharmaceutica Sinica 20030301
-
[Intractable hiccups treated with mexiletine hydrochloride].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20030210
-
A case of a short-coupled variant of torsades de Pointes with electrical storm.
Pacing and clinical electrophysiology : PACE 20030201
-
A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain.
European journal of pharmacology 20030105
-
Storms of ventricular tachyarrhythmias associated with primary hyperparathyroidism in a patient with dilated cardiomyopathy.
International journal of cardiology 20030101
-
Role of specific cytochrome P450 enzymes in the N-oxidation of the antiarrhythmic agent mexiletine.
Xenobiotica; the fate of foreign compounds in biological systems 20030101
-
The effect of commonly used drugs on angiogenesis.
Anticancer research 20030101
-
The sodium channel blocker RS100642 reverses down-regulation of the sodium channel alpha-subunit Na(v) 1.1 expression caused by transient ischemic brain injury in rats.
Neurotoxicity research 20030101
-
Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists.
Neurotoxicity research 20030101
-
Down regulation of sodium channel Na(v)1.1 expression by veratridine and its reversal by a novel sodium channel blocker, RS100642, in primary neuronal cultures.
Neurotoxicity research 20030101
-
Long-term follow-up of sudden cardiac arrest survivors and electrophysiologically guided antiarrhythmic therapy.
Cardiology 20030101
-
A patient with seizures and a positive drug screen: three wrongs don't make a right.
The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20030101
-
Stable expression and characterization of human PN1 and PN3 sodium channels.
Receptors & channels 20030101
-
Persistent pain management for improved quality of life.
Journal of the American Pharmacists Association : JAPhA 20030101
-
[Differential diagnosis of idiopathic ventricular fibrillation].
Deutsche medizinische Wochenschrift (1946) 20021122
-
The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.
Anesthesia and analgesia 20021001
-
[Diabetic neuropathy--concept, staging, diagnosis, treatment].
Nihon rinsho. Japanese journal of clinical medicine 20021001
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Modification of the fenvalerate-induced nociceptive response in mice by diabetes.
Brain research 20020906
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Mexiletine on segmental hyperhidrosis.
Journal of neurology, neurosurgery, and psychiatry 20020901
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Effects of disopyramide and mexiletine on the terminal repolarization process of the in situ heart assessed using the halothane-anesthetized in vivo canine model.
Circulation journal : official journal of the Japanese Circulation Society 20020901
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Activation-recovery interval as a parameter to assess the intracardiac ventricular repolarization in patients with congenital long QT syndrome.
The American journal of cardiology 20020815
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Comparison of the effects of four antiarrhythmic treatments for familial ventricular arrhythmias in Boxers.
Journal of the American Veterinary Medical Association 20020815
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Pharmacological rescue of mutant ion channels.
Cardiovascular research 20020801
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A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine.
Cardiovascular research 20020801
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Sodium channel-blocking agents are not of benefit to rats with kaolin-induced hydrocephalus.
Neurosurgery 20020801
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Effects of analgesics on delayed postherpetic pain in mice.
Anesthesiology 20020501
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Possible mechanism for pharmacokinetic interaction between lidocaine and mexiletine.
Clinical pharmacology and therapeutics 20020501
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Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat.
Brain research 20020405
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Cardioprotective effect of mexiletine in acute myocardial ischemia tudies in the rabbit closed chest ischemia mode.
Circulation journal : official journal of the Japanese Circulation Society 20020401
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Mexiletine related chronic defibrillation threshold elevation: case report and review of the literature.
Pacing and clinical electrophysiology : PACE 20020401
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Congenital long QT syndrome with functionally impaired atrioventricular conduction: successful treatment by mexiletine and propranolol.
Journal of the Formosan Medical Association = Taiwan yi zhi 20020401
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Lack of interaction between amiodarone and mexiletine in cardiac arrhythmia patients.
Journal of clinical pharmacology 20020301
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Sodium channel blocking actions of the kappa-opioid receptor agonist U50,488 contribute to its visceral antinociceptive effects.
Journal of neurophysiology 20020301
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Molecular basis for exaggerated sensitivity to mexiletine in the cardiac isoform of the fast Na channel.
FEBS letters 20020227
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Electrical storms in an ICD-recipient with 429 delivered appropriate shocks: therapeutic management with antiarrhythmic drug combination.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20020201
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Evaluation of mexiletine clearance in a Japanese population.
The Annals of pharmacotherapy 20020201
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Alteration of ischemic reperfusion injury in the rat neocortex by a potent antioxidant mexiletine.
Acta neurochirurgica 20020201
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Rehabilitation of peripheral nerve injuries.
Physical medicine and rehabilitation clinics of North America 20020201
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[Lipomatosis dolorosa--a frequently overlooked disease picture].
Der Nervenarzt 20020201
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Mexiletine is effective on segmental hyperhidrosis: report of two cases.
Journal of neurology, neurosurgery, and psychiatry 20020101
-
[Possibility of gene-specific treatment for hereditary arrhythmic diseases].
Nihon rinsho. Japanese journal of clinical medicine 20020101
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The cellular electrophysiologic effect of a new amiodarone like antiarrhythmic drug GYKI 16638 in undiseased human ventricular muscle: comparison with sotalol and mexiletine.
Current medicinal chemistry 20020101
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Effects of glucose-induced insulin secretion on ventricular repolarization in patients with congenital long QT syndrome.
Circulation journal : official journal of the Japanese Circulation Society 20020101
-
Schwartz-Jampel syndrome: report of one case.
Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi 20020101
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Mexiletine block of disease-associated mutations in S6 segments of the human skeletal muscle Na(+) channel.
The Journal of physiology 20011215
-
Analgesic activity of a novel use-dependent sodium channel blocker, crobenetine, in mono-arthritic rats.
British journal of pharmacology 20011201
-
Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative.
Neurology 20011127
-
Scavenger effect of experimental and clinically used cardiovascular drugs.
Journal of cardiovascular pharmacology 20011101
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Mexiletine inhibits pharmacological actions of salbutamol through blockade of beta2-adrenoceptors in bovine tracheal smooth muscle.
Naunyn-Schmiedeberg's archives of pharmacology 20011101
-
Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes.
Anesthesiology 20010901
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Lidocaine potentiates atrial natriuretic peptide-induced relaxation of bovine tracheal smooth muscle.
European journal of pharmacology 20010810
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Influence of the CYP2D6*10 allele on the metabolism of mexiletine by human liver microsomes.
British journal of clinical pharmacology 20010701
-
In vivo pharmacology of BIIR 561 CL, a novel combined antagonist of AMPA receptors and voltage-dependent Na(+) channels.
British journal of pharmacology 20010701
-
Mild alkalinization and acidification differentially modify the effects of lidocaine or mexiletine on vasorelaxation mediated by ATP-sensitive K+ channels.
Anesthesiology 20010701
-
Nociception and allodynia/hyperalgesia induced by intrathecal administration of fenvalerate.
Japanese journal of pharmacology 20010701
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Electrophysiologic effects of an antiarrhythmic agent, bidisomide, on sodium current in isolated rat ventricular myocytes: comparison with mexiletine and disopyramide.
Japanese journal of pharmacology 20010501
-
DDPH inhibited L-type calcium current and sodium current in single ventricular myocyte of guinea pig.
Acta pharmacologica Sinica 20010501
-
The use-dependent sodium channel blocker mexiletine is neuroprotective against global ischemic injury.
Brain research 20010420
-
Normalization of ventricular repolarization with flecainide in long QT syndrome patients with SCN5A:DeltaKPQ mutation.
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20010401
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Suppressive effects of oxcarbazepine on tooth pulp-evoked potentials recorded at the trigeminal spinal tract nucleus in cats.
Clinical and experimental pharmacology & physiology 20010301
-
Effect of fluvoxamine on the pharmacokinetics of mexiletine in healthy Japanese men.
Clinical pharmacology and therapeutics 20010301
-
[Enantioseparation of twelve pharmaceutical racemates with high performance capillary electrophoresis using L-leucine as chiral selector].
Se pu = Chinese journal of chromatography 20010301
-
Effect of drugs used for neuropathic pain management on tetrodotoxin-resistant Na(+) currents in rat sensory neurons.
Anesthesiology 20010101
-
Regional block and mexiletine: the effect on pain after cancer breast surgery.
Regional anesthesia and pain medicine 20010101
-
Acute exanthematous pustular drug eruption induced by mexiletine.
European journal of dermatology : EJD 20010101
-
[Paramyotonia congenita].
Ryoikibetsu shokogun shirizu 20010101
-
[Na channel myotonia].
Ryoikibetsu shokogun shirizu 20010101
-
Effects of mexiletine on the canine cardiovascular system complicating cisapride overdose: potential utility of mexiletine for the treatment of drug-induced long QT syndrome.
Japanese journal of pharmacology 20000801
-
Efficacy of oral mexiletine for neuropathic pain with allodynia: a double-blind, placebo-controlled, crossover study.
Regional anesthesia and pain medicine 20000101
-
Effect of oral mexiletine on capsaicin-induced allodynia and hyperalgesia: a double-blind, placebo-controlled, crossover study.
Regional anesthesia and pain medicine 20000101
-
Lack of stereoselectivity for the antiallodynic effect of mexiletine in spinally injured rats.
European journal of pain (London, England) 20000101
-
Effects of mexiletine on algogenic mediator-induced nociceptive responses in mice.
Methods and findings in experimental and clinical pharmacology 19990101
-
Mexiletine-induced severe skin eruption, fever, eosinophilia, atypical lymphocytosis, and liver dysfunction.
Pain 19971001
-
Usefulness of oral quinidine-mexiletine combination therapy for sustained ventricular tachyarrhythmias as assessed by programmed electrical stimulation when quinidine monotherapy has failed.
American heart journal 19940401
-
Neurotoxicity of lidocaine combined with mexiletine.
Anesthesia and analgesia 19931201
-
Mexiletine's antifibrillatory actions are limited by the occurrence of convulsions in conscious animals.
European journal of pharmacology 19920121
-
Mexiletine-associated left ventricular dysfunction: a case study.
Maryland medical journal (Baltimore, Md. : 1985) 19910601
-
Long-term effect of mexiletine on left ventricular function and relation to suppression of ventricular arrhythmia.
The American journal of cardiology 19901115
-
Combined application of class I antiarrhythmic drugs causes 'additive', 'reductive', or 'synergistic' sodium channel block in cardiac muscles.
Cardiovascular research 19901101
-
Changes in cardiac output determined by continuous-wave Doppler echocardiography during propafenone or mexiletine drug testing.
The American journal of cardiology 19900215
-
Congestive heart failure induced by six of the newer antiarrhythmic drugs.
Journal of the American College of Cardiology 19891101
-
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system.
Arzneimittel-Forschung 19881001
-
Comparative efficacy and safety of oral mexiletine and quinidine in benign or potentially lethal ventricular arrhythmias.
The American journal of cardiology 19871201
-
[2 cases of lidocaine-resistant ventricular tachycardia treated with i.v. mexiletine during complicated acute myocardial infarct].
La Clinica terapeutica 19871130
-
Pharmacological investigation of a new anti-arrhythmic agent, GYKI-23 107.
Drugs under experimental and clinical research 19870101
-
[Anti-arrhythmic efficacy of the amiodarone-mexiletine combination in the treatment of resistant complex ventricular arrhythmias].
Giornale italiano di cardiologia 19860501
-
Mexiletine: long-term follow-up of a patient with prolonged QT interval and quinidine-induced torsades de pointes.
Southern medical journal 19850201
-
Inhibition of sympathetic nervous system by mexiletine, an antiarrhythmic agent, and its antagonism against ouabain.
Arzneimittel-Forschung 19850101
-
International mexiletine and placebo antiarrhythmic coronary trial: I. Report on arrhythmia and other findings. Impact Research Group.
Journal of the American College of Cardiology 19841201
-
Mexiletine for recurring ventricular arrhythmias: assessment by long-term electrocardiographic recordings and sequential electrophysiologic studies.
American heart journal 19840901
-
Hemodynamic effects of mexiletine.
American heart journal 19840501
-
Mexiletine in refractory ventricular arrhythmias.
Clinical pharmacology and therapeutics 19831201
-
Quantitative analysis of the antiarrhythmic effect of drugs on canine ventricular arrhythmias by the determination of minimum effective plasma concentrations.
Japanese circulation journal 19830101
-
[Sulfinpyrazone-associated renal failure (author's transl)].
Deutsche medizinische Wochenschrift (1946) 19820709
-
[Mexiletine in the treatment of lidocaine-resistant ventricular tachycardia. Preliminary results].
Giornale italiano di cardiologia 19820101
-
New drugs for treating cardiac arrhythmias.
Postgraduate medicine 19810101
-
Torsades de pointes as a manifestation of mexiletine toxicity.
American heart journal 19801201
-
Mexiletine in the treatment of ventricular arrhythmias.
Acta cardiologica. Supplementum 19800101