5370-01-4 | 2-(2-aminopropoxy)-1,3-dimethylbenzene hydrochloride

Packsize	Purity	Availability	Price	Discounted Price
25mg	99%	in stock	$6.00	$4.00
100mg	99%	in stock	$8.00	$6.00
5g	98%	in stock	$26.00	$18.00
25g	99%	in stock	$36.00	$25.00
500g	98%	in stock	$605.00	$423.00

Description

• Catalog Number: AB76226
• Chemical Name: 2-(2-aminopropoxy)-1,3-dimethylbenzene hydrochloride
• CAS Number: 5370-01-4
• Molecular Formula: C11H18ClNO
• Molecular Weight: 215.7197
• MDL Number: MFCD00216024
• SMILES: CC(COc1c(C)cccc1C)N.Cl
• NSC Number: 758639

Computed Properties

• Complexity: 139
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• Undefined Atom Stereocenter Count: 1

Literature

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  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20050201

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  Diabetic medicine : a journal of the British Diabetic Association 20041001

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  Therapeutic drug monitoring 20041001

• Enantiomeric separation of basic drugs with partially filled serum albumin as chiral selector in capillary electrophoresis.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20041001

• A case of primary erythromelalgia improved by mexiletine.

  The British journal of dermatology 20040901

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  Neuromuscular disorders : NMD 20040701

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  Journal of electrocardiology 20040701

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  Annals of nuclear medicine 20040501

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  Biochemical pharmacology 20040301

• Frequent ventricular extrasystole treated by needling neiguan (PC 6) plus oral administration of mexiletine--a report of 30 cases.

  Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20040301

• Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na+ channels.

  The Journal of physiology 20040201

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  Chirality 20040201

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  Neurology 20040127

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  Current medicinal chemistry 20040101

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  Clinical and experimental pharmacology & physiology 20040101

• Inactivation-deficient human skeletal muscle Na+ channels (hNav1.4-L443C/A444W) in stably transfected HEK-293 cells.

  Receptors & channels 20040101

• Comparison of classical and derivative UV-spectrophotometric methods for the quantification of diltiazem and mexiletine.

  Acta poloniae pharmaceutica 20040101

• Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels.

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• Akt activation induced by an antioxidant compound during ischemia-reperfusion.

  Free radical biology & medicine 20031101

• Effects of mexiletine, ginkgo biloba extract (EGb 761), and their combination on experimental head injury.

  Neurosurgical review 20031001

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  The Journal of pharmacy and pharmacology 20031001

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• Nifekalant hydrochloride, a novel class III antiarrhythmic agent, suppressed postoperative recurrent ventricular tachycardia in a patient undergoing coronary artery bypass grafting and the Dor approach.

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• Mexiletine carbonyloxy beta-D-glucuronide: a novel metabolite in human urine.

  Xenobiotica; the fate of foreign compounds in biological systems 20030801

• Development of enzyme-linked immunosorbent assay for therapeutic drug monitoring of mexiletine.

  Biological & pharmaceutical bulletin 20030601

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  Brain : a journal of neurology 20030401

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  Annales de dermatologie et de venereologie 20030401

• Mexiletine inhibits nonadrenergic noncholinergic lower oesophageal sphincter relaxation in rabbits.

  European journal of pharmacology 20030328

• Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice.

  Cardiovascular research 20030315

• Mexiletine differentially modulates vasorelaxation mediated by adenosine triphosphate-sensitive K+ channels in aortas from normotensive and hypertensive rats.

  Anesthesia and analgesia 20030301

• Ventricular tachyarrhythmias in a canine model of LQT3: arrhythmogenic effects of sympathetic activity and therapeutic effects of mexiletine.

  Circulation journal : official journal of the Japanese Circulation Society 20030301

• Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile.

  Naunyn-Schmiedeberg's archives of pharmacology 20030301

• [HPLC-fluorescent spectrometric determination of serum mexiletine concentration after derivatization with fluram].

  Yao xue xue bao = Acta pharmaceutica Sinica 20030301

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  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20030210

• A case of a short-coupled variant of torsades de Pointes with electrical storm.

  Pacing and clinical electrophysiology : PACE 20030201

• A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain.

  European journal of pharmacology 20030105

• Storms of ventricular tachyarrhythmias associated with primary hyperparathyroidism in a patient with dilated cardiomyopathy.

  International journal of cardiology 20030101

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  Xenobiotica; the fate of foreign compounds in biological systems 20030101

• The effect of commonly used drugs on angiogenesis.

  Anticancer research 20030101

• The sodium channel blocker RS100642 reverses down-regulation of the sodium channel alpha-subunit Na(v) 1.1 expression caused by transient ischemic brain injury in rats.

  Neurotoxicity research 20030101

• Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists.

  Neurotoxicity research 20030101

• Down regulation of sodium channel Na(v)1.1 expression by veratridine and its reversal by a novel sodium channel blocker, RS100642, in primary neuronal cultures.

  Neurotoxicity research 20030101

• Long-term follow-up of sudden cardiac arrest survivors and electrophysiologically guided antiarrhythmic therapy.

  Cardiology 20030101

• A patient with seizures and a positive drug screen: three wrongs don't make a right.

  The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20030101

• Stable expression and characterization of human PN1 and PN3 sodium channels.

  Receptors & channels 20030101

• Persistent pain management for improved quality of life.

  Journal of the American Pharmacists Association : JAPhA 20030101

• [Differential diagnosis of idiopathic ventricular fibrillation].

  Deutsche medizinische Wochenschrift (1946) 20021122

• The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.

  Anesthesia and analgesia 20021001

• [Diabetic neuropathy--concept, staging, diagnosis, treatment].

  Nihon rinsho. Japanese journal of clinical medicine 20021001

• Modification of the fenvalerate-induced nociceptive response in mice by diabetes.

  Brain research 20020906

• Mexiletine on segmental hyperhidrosis.

  Journal of neurology, neurosurgery, and psychiatry 20020901

• Effects of disopyramide and mexiletine on the terminal repolarization process of the in situ heart assessed using the halothane-anesthetized in vivo canine model.

  Circulation journal : official journal of the Japanese Circulation Society 20020901

• Activation-recovery interval as a parameter to assess the intracardiac ventricular repolarization in patients with congenital long QT syndrome.

  The American journal of cardiology 20020815

• Comparison of the effects of four antiarrhythmic treatments for familial ventricular arrhythmias in Boxers.

  Journal of the American Veterinary Medical Association 20020815

• Pharmacological rescue of mutant ion channels.

  Cardiovascular research 20020801

• A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine.

  Cardiovascular research 20020801

• Sodium channel-blocking agents are not of benefit to rats with kaolin-induced hydrocephalus.

  Neurosurgery 20020801

• Effects of analgesics on delayed postherpetic pain in mice.

  Anesthesiology 20020501

• Possible mechanism for pharmacokinetic interaction between lidocaine and mexiletine.

  Clinical pharmacology and therapeutics 20020501

• Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat.

  Brain research 20020405

• Cardioprotective effect of mexiletine in acute myocardial ischemia tudies in the rabbit closed chest ischemia mode.

  Circulation journal : official journal of the Japanese Circulation Society 20020401

• Mexiletine related chronic defibrillation threshold elevation: case report and review of the literature.

  Pacing and clinical electrophysiology : PACE 20020401

• Congenital long QT syndrome with functionally impaired atrioventricular conduction: successful treatment by mexiletine and propranolol.

  Journal of the Formosan Medical Association = Taiwan yi zhi 20020401

• Lack of interaction between amiodarone and mexiletine in cardiac arrhythmia patients.

  Journal of clinical pharmacology 20020301

• Sodium channel blocking actions of the kappa-opioid receptor agonist U50,488 contribute to its visceral antinociceptive effects.

  Journal of neurophysiology 20020301

• Molecular basis for exaggerated sensitivity to mexiletine in the cardiac isoform of the fast Na channel.

  FEBS letters 20020227

• Electrical storms in an ICD-recipient with 429 delivered appropriate shocks: therapeutic management with antiarrhythmic drug combination.

  Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20020201

• Evaluation of mexiletine clearance in a Japanese population.

  The Annals of pharmacotherapy 20020201

• Alteration of ischemic reperfusion injury in the rat neocortex by a potent antioxidant mexiletine.

  Acta neurochirurgica 20020201

• Rehabilitation of peripheral nerve injuries.

  Physical medicine and rehabilitation clinics of North America 20020201

• [Lipomatosis dolorosa--a frequently overlooked disease picture].

  Der Nervenarzt 20020201

• Mexiletine is effective on segmental hyperhidrosis: report of two cases.

  Journal of neurology, neurosurgery, and psychiatry 20020101

• [Possibility of gene-specific treatment for hereditary arrhythmic diseases].

  Nihon rinsho. Japanese journal of clinical medicine 20020101

• The cellular electrophysiologic effect of a new amiodarone like antiarrhythmic drug GYKI 16638 in undiseased human ventricular muscle: comparison with sotalol and mexiletine.

  Current medicinal chemistry 20020101

• Effects of glucose-induced insulin secretion on ventricular repolarization in patients with congenital long QT syndrome.

  Circulation journal : official journal of the Japanese Circulation Society 20020101

• Schwartz-Jampel syndrome: report of one case.

  Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi 20020101

• Mexiletine block of disease-associated mutations in S6 segments of the human skeletal muscle Na(+) channel.

  The Journal of physiology 20011215

• Analgesic activity of a novel use-dependent sodium channel blocker, crobenetine, in mono-arthritic rats.

  British journal of pharmacology 20011201

• Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative.

  Neurology 20011127

• Scavenger effect of experimental and clinically used cardiovascular drugs.

  Journal of cardiovascular pharmacology 20011101

• Mexiletine inhibits pharmacological actions of salbutamol through blockade of beta2-adrenoceptors in bovine tracheal smooth muscle.

  Naunyn-Schmiedeberg's archives of pharmacology 20011101

• Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes.

  Anesthesiology 20010901

• Lidocaine potentiates atrial natriuretic peptide-induced relaxation of bovine tracheal smooth muscle.

  European journal of pharmacology 20010810

• Influence of the CYP2D6*10 allele on the metabolism of mexiletine by human liver microsomes.

  British journal of clinical pharmacology 20010701

• In vivo pharmacology of BIIR 561 CL, a novel combined antagonist of AMPA receptors and voltage-dependent Na(+) channels.

  British journal of pharmacology 20010701

• Mild alkalinization and acidification differentially modify the effects of lidocaine or mexiletine on vasorelaxation mediated by ATP-sensitive K+ channels.

  Anesthesiology 20010701

• Nociception and allodynia/hyperalgesia induced by intrathecal administration of fenvalerate.

  Japanese journal of pharmacology 20010701

• Electrophysiologic effects of an antiarrhythmic agent, bidisomide, on sodium current in isolated rat ventricular myocytes: comparison with mexiletine and disopyramide.

  Japanese journal of pharmacology 20010501

• DDPH inhibited L-type calcium current and sodium current in single ventricular myocyte of guinea pig.

  Acta pharmacologica Sinica 20010501

• The use-dependent sodium channel blocker mexiletine is neuroprotective against global ischemic injury.

  Brain research 20010420

• Normalization of ventricular repolarization with flecainide in long QT syndrome patients with SCN5A:DeltaKPQ mutation.

  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20010401

• Suppressive effects of oxcarbazepine on tooth pulp-evoked potentials recorded at the trigeminal spinal tract nucleus in cats.

  Clinical and experimental pharmacology & physiology 20010301

• Effect of fluvoxamine on the pharmacokinetics of mexiletine in healthy Japanese men.

  Clinical pharmacology and therapeutics 20010301

• [Enantioseparation of twelve pharmaceutical racemates with high performance capillary electrophoresis using L-leucine as chiral selector].

  Se pu = Chinese journal of chromatography 20010301

• Effect of drugs used for neuropathic pain management on tetrodotoxin-resistant Na(+) currents in rat sensory neurons.

  Anesthesiology 20010101

• Regional block and mexiletine: the effect on pain after cancer breast surgery.

  Regional anesthesia and pain medicine 20010101

• Acute exanthematous pustular drug eruption induced by mexiletine.

  European journal of dermatology : EJD 20010101

• [Paramyotonia congenita].

  Ryoikibetsu shokogun shirizu 20010101

• [Na channel myotonia].

  Ryoikibetsu shokogun shirizu 20010101

• Effects of mexiletine on the canine cardiovascular system complicating cisapride overdose: potential utility of mexiletine for the treatment of drug-induced long QT syndrome.

  Japanese journal of pharmacology 20000801

• Efficacy of oral mexiletine for neuropathic pain with allodynia: a double-blind, placebo-controlled, crossover study.

  Regional anesthesia and pain medicine 20000101

• Effect of oral mexiletine on capsaicin-induced allodynia and hyperalgesia: a double-blind, placebo-controlled, crossover study.

  Regional anesthesia and pain medicine 20000101

• Lack of stereoselectivity for the antiallodynic effect of mexiletine in spinally injured rats.

  European journal of pain (London, England) 20000101

• Effects of mexiletine on algogenic mediator-induced nociceptive responses in mice.

  Methods and findings in experimental and clinical pharmacology 19990101

• Mexiletine-induced severe skin eruption, fever, eosinophilia, atypical lymphocytosis, and liver dysfunction.

  Pain 19971001

• Usefulness of oral quinidine-mexiletine combination therapy for sustained ventricular tachyarrhythmias as assessed by programmed electrical stimulation when quinidine monotherapy has failed.

  American heart journal 19940401

• Neurotoxicity of lidocaine combined with mexiletine.

  Anesthesia and analgesia 19931201

• Mexiletine's antifibrillatory actions are limited by the occurrence of convulsions in conscious animals.

  European journal of pharmacology 19920121

• Mexiletine-associated left ventricular dysfunction: a case study.

  Maryland medical journal (Baltimore, Md. : 1985) 19910601

• Long-term effect of mexiletine on left ventricular function and relation to suppression of ventricular arrhythmia.

  The American journal of cardiology 19901115

• Combined application of class I antiarrhythmic drugs causes 'additive', 'reductive', or 'synergistic' sodium channel block in cardiac muscles.

  Cardiovascular research 19901101

• Changes in cardiac output determined by continuous-wave Doppler echocardiography during propafenone or mexiletine drug testing.

  The American journal of cardiology 19900215

• Congestive heart failure induced by six of the newer antiarrhythmic drugs.

  Journal of the American College of Cardiology 19891101

• General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system.

  Arzneimittel-Forschung 19881001

• Comparative efficacy and safety of oral mexiletine and quinidine in benign or potentially lethal ventricular arrhythmias.

  The American journal of cardiology 19871201

• [2 cases of lidocaine-resistant ventricular tachycardia treated with i.v. mexiletine during complicated acute myocardial infarct].

  La Clinica terapeutica 19871130

• Pharmacological investigation of a new anti-arrhythmic agent, GYKI-23 107.

  Drugs under experimental and clinical research 19870101

• [Anti-arrhythmic efficacy of the amiodarone-mexiletine combination in the treatment of resistant complex ventricular arrhythmias].

  Giornale italiano di cardiologia 19860501

• Mexiletine: long-term follow-up of a patient with prolonged QT interval and quinidine-induced torsades de pointes.

  Southern medical journal 19850201

• Inhibition of sympathetic nervous system by mexiletine, an antiarrhythmic agent, and its antagonism against ouabain.

  Arzneimittel-Forschung 19850101

• International mexiletine and placebo antiarrhythmic coronary trial: I. Report on arrhythmia and other findings. Impact Research Group.

  Journal of the American College of Cardiology 19841201

• Mexiletine for recurring ventricular arrhythmias: assessment by long-term electrocardiographic recordings and sequential electrophysiologic studies.

  American heart journal 19840901

• Hemodynamic effects of mexiletine.

  American heart journal 19840501

• Mexiletine in refractory ventricular arrhythmias.

  Clinical pharmacology and therapeutics 19831201

• Quantitative analysis of the antiarrhythmic effect of drugs on canine ventricular arrhythmias by the determination of minimum effective plasma concentrations.

  Japanese circulation journal 19830101

• [Sulfinpyrazone-associated renal failure (author's transl)].

  Deutsche medizinische Wochenschrift (1946) 19820709

• [Mexiletine in the treatment of lidocaine-resistant ventricular tachycardia. Preliminary results].

  Giornale italiano di cardiologia 19820101

• New drugs for treating cardiac arrhythmias.

  Postgraduate medicine 19810101

• Torsades de pointes as a manifestation of mexiletine toxicity.

  American heart journal 19801201

• Mexiletine in the treatment of ventricular arrhythmias.

  Acta cardiologica. Supplementum 19800101