54-21-7 | Sodium salicylate

Packsize	Purity	Availability	Price	Discounted Price
500g	98%	in stock	$16.00	$11.00
1000g	98%	in stock	$30.00	$21.00

Description

• Catalog Number: AB79153
• Chemical Name: Sodium salicylate
• CAS Number: 54-21-7
• Molecular Formula: C7H6NaO3
• Molecular Weight: 161.11050999999998
• MDL Number: MFCD00002440
• SMILES: OC(=O)c1ccccc1O.[Na]

Computed Properties

• Complexity: 138
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1

Upstream Synthesis Route

Benzoic acid, 2-hydroxy-, sodium salt is commonly utilized in chemical synthesis as a versatile reagent. Its hydroxy and carboxylic acid functional groups make it a valuable component in organic reactions. This compound is frequently employed as a catalyst or a source of the 2-hydroxybenzoic acid moiety in the synthesis of various pharmaceuticals, industrial chemicals, and organic compounds. Additionally, it can serve as a key intermediate in the preparation of esters, ethers, and amides, contributing to the diversification of chemical structures in synthesis processes.

Literature

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• Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1.

  Pharmacological research 20141101

• Single high-dose dexamethasone and sodium salicylate failed to attenuate phosgene-induced acute lung injury in rats.

  Toxicology 20140106

• Assessment of ABCG2-mediated transport of xenobiotics across the blood-milk barrier of dairy animals using a new MDCKII in vitro model.

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• Quercetin and quercetin-3-O-glucuronide are equally effective in ameliorating endothelial insulin resistance through inhibition of reactive oxygen species-associated inflammation.

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• Auditory brainstem response as a possible objective indicator for salicylate-induced tinnitus in rats.

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• Suppressive effects of nonsteroidal anti-inflammatory drugs diclofenac sodium, salicylate and indomethacin on delayed rectifier K+-channel currents in murine thymocytes.

  Immunopharmacology and immunotoxicology 20121001

• Chemiluminescence characteristics of furan derivatives as blue fluorescers in peroxyoxalate-hydrogen peroxide system.

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• Phase I trial of sodium salicylate in patients with myelodysplastic syndromes and acute myelogenous leukemia.

  Leukemia research 20120501

• Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization.

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• Facilitation of human osteoblast apoptosis by sulindac and indomethacin under hypoxic injury.

  Journal of cellular biochemistry 20120101

• Altered neuronal intrinsic properties and reduced synaptic transmission of the rat's medial geniculate body in salicylate-induced tinnitus.

  PloS one 20120101

• Transcutaneous immunization system using a hydrotropic formulation induces a potent antigen-specific antibody response.

  PloS one 20120101

• Effect of intravenous sodium salicylate administration prior to castration on plasma cortisol and electroencephalography parameters in calves.

  Journal of veterinary pharmacology and therapeutics 20111201

• Modeling diabetes disease progression and salsalate intervention in Goto-Kakizaki rats.

  The Journal of pharmacology and experimental therapeutics 20111201

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• In vivo sodium salicylate causes tolerance to acute morphine exposure and alters the ability of high frequency stimulation to induce long-term potentiation in hippocampus area CA1.

  European journal of pharmacology 20111130

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• Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves following castration and dehorning.

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• Application of hydrotropy to transdermal formulations: hydrotropic solubilization of polyol fatty acid monoesters in water and enhancement effect on skin permeation of 5-FU.

  The Journal of pharmacy and pharmacology 20110801

• Spontaneous reversibility of damage to outer hair cells after sodium salicylate induced ototoxicity.

  The Journal of laryngology and otology 20110801

• Membrane cholesterol modulates cochlear electromechanics.

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• Effect of sodium salicylate, sodium oxalate, and sodium chloride on the micellization and adsorption of sodium deoxycholate in aqueous solutions.

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  Journal of oleo science 20110101

• Pharmacodynamics of tepoxalin, sodium-salicylate and ketoprofen in an intravenous lipopolysaccharide inflammation model in broiler chickens.

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• Salicylate prevents hepatic oxidative stress activation caused by short-term elevation of free fatty acids in vivo.

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  European journal of pharmacology 20100725

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  Ultrasonics sonochemistry 20100101

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• Salicylate, an aspirin metabolite, specifically inhibits the current mediated by glycine receptors containing alpha1-subunits.

  British journal of pharmacology 20090801

• Analgesic efficacy of sodium salicylate in an amphotericin B-induced bovine synovitis-arthritis model.

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• Differential effects of sodium salicylate on current-evoked firing of pyramidal neurons and fast-spiking interneurons in slices of rat auditory cortex.

  Hearing research 20090701

• Effects of mitogen-activated protein kinase signal pathway on heat shock protein 27 expression in human lens epithelial cells exposed to sodium salicylate in vitro.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20090601

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  Molecular cancer research : MCR 20090501

• Salicylate-induced morphological changes of isolated inner hair cells and outer hair cells from guinea-pig cochlea.

  Auris, nasus, larynx 20090401

• Ion-exchange membrane assisted transdermal iontophoretic delivery of salicylate and acyclovir.

  International journal of pharmaceutics 20090318

• Characterization of the ligand and DNA binding properties of a putative archaeal regulator ST1710.

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  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20090201

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  International journal of audiology 20090101

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  Cellular and molecular life sciences : CMLS 20080801

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  American journal of physiology. Heart and circulatory physiology 20080701

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  Biochemistry. Biokhimiia 20080701

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  Environmental science & technology 20080601

• Effect of vasoactive agents on the dermatopharmacokinetics and systemic disposition of model compounds, salicylate and FITC-dextran 4 kDa, following intracutaneous injection of the compounds.

  International journal of pharmaceutics 20080522

• Towards elucidation of the drug release mechanism from compressed hydrophilic matrices made of cellulose ethers. I. Pulse-field-gradient spin-echo NMR study of sodium salicylate diffusivity in swollen hydrogels with respect to polymer matrix physical structure.

  Journal of controlled release : official journal of the Controlled Release Society 20080522

• Implication of NAG-1 in synergistic induction of apoptosis by combined treatment of sodium salicylate and PI3K/MEK1/2 inhibitors in A549 human lung adenocarcinoma cells.

  Biochemical pharmacology 20080501

• Sodium salicylate switches glucose depletion-induced necrosis to autophagy and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells.

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• [Effect of sodium salicylate on the auditory brain stem response threshold and expression of glutamic acid decarboxylase in spiral ganglion of juvenile and adult guinea pigs].

  Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20080501

• The role of prestin in the generation of electrically evoked otoacoustic emissions in mice.

  Journal of neurophysiology 20080401

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  Hearing research 20080201

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• Synthesis and characterization of microparticles made of carboxymethyloxysuccinic-acid-modified PLA-PEG co-polymer.

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  Nature methods 20071101

• Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo.

  The Journal of endocrinology 20071101

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• Development and characterisation of interactive mixtures with a fine-particulate mucoadhesive carrier for nasal drug delivery.

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• Broad bandwidth optical and mechanical rheometry of wormlike micelle solutions.

  Physical review letters 20070810

• Attenuation of acute plasma cortisol response in calves following intravenous sodium salicylate administration prior to castration.

  Journal of veterinary pharmacology and therapeutics 20070801

• Sodium salicylate prevents paraquat-induced apoptosis in the rat lung.

  Free radical biology & medicine 20070701

• Dermatopharmacokinetics of salicylate following topical injection in rats: effect of osmotic pressure and injection volume on salicylate disposition.

  International journal of pharmaceutics 20070607

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  Hearing research 20070601

• Differential gene expression profiles in salicylate ototoxicity of the mouse.

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  Hearing research 20070401

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  Free radical biology & medicine 20070401

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  Anesthesia and analgesia 20070401

• Evidence that oxymorphone-induced increases in micronuclei occur secondary to hyperthermia.

  Toxicological sciences : an official journal of the Society of Toxicology 20070201

• Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy.

  Diabetes 20070201

• Development of a highly sensitive and selective microplate chemiluminescence enzyme immunoassay for the determination of free thyroxine in human serum.

  International journal of biological sciences 20070101

• Comparison of the effects of tens and sodium salicylate iontophoresis in the management of osteoarthritis of the knee.

  Nigerian quarterly journal of hospital medicine 20070101

• ATR-FTIR and XPS study on the structure of complexes formed upon the adsorption of simple organic acids on aluminum hydroxide.

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  Nigerian quarterly journal of hospital medicine 20070101

• Influence of polyethylene oxide on the rheological properties of semidilute, wormlike micellar solutions of hexadecyltrimethylammonium chloride and sodium salicylate.

  Journal of colloid and interface science 20061215

• The phenylic hydroxyl group is essential for the induction of stress response by sodium salicylate.

  Biochemical and biophysical research communications 20061110

• Biodegradation of phenol and sodium salicylate mixtures by suspended Pseudomonas putida CCRC 14365.

  Journal of hazardous materials 20061102

• Aspirin and salicylate suppress polymorphonuclear apoptosis delay mediated by proinflammatory stimuli.

  The Journal of pharmacology and experimental therapeutics 20061101

• Enhanced biodegradation of mixed phenol and sodium salicylate by Pseudomonas putida in membrane contactors.

  Water research 20061101

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  Clinical and experimental pharmacology & physiology 20061101

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  Food additives and contaminants 20061101

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  Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20061001

• Cisplatin ototoxicity and otoprotection with sodium salicylate.

  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20060901

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  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060701

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  Hearing research 20060501

• The anti-gastropathic and anti-rheumatic effect of niga-ichigoside F1 and 23-hydroxytormentic acid isolated from the unripe fruits of Rubus coreanus in a rat model.

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  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20060501

• Bis(trimethoxysilylpropyl)amine and tetraethoxysilane derived gels as effective controlled release carriers for water-soluble drugs of small molecules.

  Colloids and surfaces. B, Biointerfaces 20060415

• Biopharmaceutic and pharmacokinetic studies following the oral administration of sodium salicylate in oily and aqueous vehicles to rabbit.

  International journal of pharmaceutics 20060327

• Effects of incorporated drugs on degradation of novel 2,2'-bis(2-oxazoline) linked poly(lactic acid) films.

  International journal of pharmaceutics 20060309

• Depolarization of cochlear outer hair cells evokes active hair bundle motion by two mechanisms.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060308

• Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301

• Sodium salicylate inhibits TNF-alpha-induced NF-kappaB activation, cell migration, invasion and ICAM-1 expression in human melanoma cells.

  Melanoma research 20060201

• Sodium salicylate promotes neutrophil apoptosis by stimulating caspase-dependent turnover of Mcl-1.

  Journal of immunology (Baltimore, Md. : 1950) 20060115

• Effects of sodium salicylate on the expression of HSP27 protein during oxidative stress in tissue-cultured human lens epithelial cells.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20060101

• Salicylate activity. 1. Protection of plants from paraquat injury.

  Journal of agricultural and food chemistry 20051214

• Salicylate activity. 2. Potentiation of atrazine.

  Journal of agricultural and food chemistry 20051214

• Gene expression profiling analysis of Mycobacterium tuberculosis genes in response to salicylate.

  Archives of microbiology 20051101

• Implication of reactive oxygen species, ERK1/2, and p38MAPK in sodium salicylate-induced heat shock protein 72 expression in C6 glioma cells.

  International journal of molecular medicine 20051101

• Preparation of two-drug composite microparticles to improve the dissolution of insoluble drug in water for use with a 4-fluid nozzle spray drier.

  Journal of controlled release : official journal of the Controlled Release Society 20051020

• Inducible cyclooxygenase released prostaglandin mediates immunosuppression in acute phase of experimental Trypanosoma cruzi infection.

  Experimental parasitology 20051001

• Interaction of bilirubin with sealed and human serum albumin-entrapped sealed membranes.

  Molecular and cellular biochemistry 20050901

• Salicylate blocks L-type calcium channels in rat inferior colliculus neurons.

  Hearing research 20050701

• Nonsteroidal anti-inflammatory drugs differentially affect the heat shock response in cultured spinal cord cells.

  Cell stress & chaperones 20050701

• Sodium salicylate reduces gamma aminobutyric acid-induced current in rat spinal dorsal horn neurons.

  Neuroreport 20050531

• Distinct differences between TNF receptor 1- and TNF receptor 2-mediated activation of NFkappaB.

  Journal of biochemistry and molecular biology 20050531

• The effect of additives on the water solubilization capacity and conductivity in n-pentanol microemulsions.

  Journal of colloid and interface science 20050501

• Paradoxical enhancement of active cochlear mechanics in long-term administration of salicylate.

  Journal of neurophysiology 20050401

• Antipyretic effect of oral sodium salicylate after an intravenous E. coli LPS injection in broiler chickens.

  British poultry science 20050401

• Sodium salicylate attenuates lipopolysaccharide (LPS)-induced adipsia, but not hypophagia, in broiler chickens.

  British poultry science 20050401

• Effects of non-steroidal anti-inflammatory drugs on pain-related behaviour in a model of articular pain in the domestic fowl.

  Research in veterinary science 20050201

• Phenolic compounds, sodium salicylate and related compounds, as inhibitors of tumor cell growth and inducers of apoptosis in mouse leukemia L1210 cells.

  In vivo (Athens, Greece) 20050101

• Vertebral malformations induced by sodium salicylate correlate with shifts in expression domains of Hox genes.

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• Relevance of platelet-independent effects of aspirin to its salutary effect in atherosclerosis-related events.

  Journal of atherosclerosis and thrombosis 20050101

• Shear banding fluctuations and nematic order in wormlike micelles.

  Physical review letters 20041231

• Chlorpromazine inhibits cochlear function in guinea pigs.

  Hearing research 20041201

• Antioxidant protection in a new animal model of cisplatin-induced ototoxicity.

  Hearing research 20041201

• Enhanced active efflux, repression of porin synthesis and development of Mar phenotype by diazepam in two enterobacteria strains.

  Journal of medical microbiology 20041101

• Suppression of heat- and polyglutamine-induced cytotoxicity by nonsteroidal anti-inflammatory drugs.

  European journal of biochemistry 20041101

• Sodium salicylate inhibits NF-kappaB and induces apoptosis in PC12 cells.

  Journal of biochemical and biophysical methods 20041029

• Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta.

  The Journal of clinical endocrinology and metabolism 20041001

• Effect of corticosteroid on salicylate-induced morphological changes of isolated cochlear outer hair cells.

  The Annals of otology, rhinology, and laryngology 20040901

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  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040701

• Induction of transcription by p21Waf1/Cip1/Sdi1: role of NFkappaB and effect of non-steroidal anti-inflammatory drugs.

  Cell cycle (Georgetown, Tex.) 20040701

• Effects of salicylate on voltage-gated sodium channels in rat inferior colliculus neurons.

  Hearing research 20040701

• Hydrotropic agents for study of in vitro paclitaxel release from polymeric micelles.

  Journal of controlled release : official journal of the Controlled Release Society 20040618

• Comparative metabolic excretion profile of sodium salicylate in broiler chickens and homing pigeons.

  Journal of veterinary pharmacology and therapeutics 20040401

• Oral vaccination of African catfish with Vibrio anguillarum O2: effect on antigen uptake and immune response by absorption enhancers in lag time coated pellets.

  Fish & shellfish immunology 20040301

• Use of the ninhydrin assay to measure the release of chitosan from oral solid dosage forms.

  International journal of pharmaceutics 20040301

• Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases.

  Neuroscience letters 20040212

• Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts.

  Molecular pharmacology 20040201

• Salicylate regulates COX-2 expression through ERK and subsequent NF-kappaB activation in osteoblasts.

  Immunopharmacology and immunotoxicology 20040201

• Enhanced ileal absorption of a hydrophilic macromolecule, pentosan polysulfate sodium (PPS).

  Journal of biomaterials science. Polymer edition 20040101

• The effects of water supplementation with vitamin E and sodium salicylate (Uni-Sol) on the resistance of turkeys to Escherichia coli respiratory infection.

  Avian diseases 20040101

• Expression of c-fos in auditory and non-auditory brain regions of the gerbil after manipulations that induce tinnitus.

  Experimental brain research 20031201

• PepN is the major aminopeptidase in Escherichia coli: insights on substrate specificity and role during sodium-salicylate-induced stress.

  Microbiology (Reading, England) 20031201

• Effect of shape of sodium salicylate particles on physical property and in vitro aerosol performance of granules prepared by pressure swing granulation method.

  AAPS PharmSciTech 20031201

• Facilitation of iontophoretic drug delivery through intact and caries-affected dentine.

  International endodontic journal 20031001

• Aspirin and salicylate inhibit colon cancer medium- and VEGF-induced endothelial tube formation: correlation with suppression of cyclooxygenase-2 expression.

  Journal of thrombosis and haemostasis : JTH 20031001

• Evaluation of anhydride oligomers within polymer microsphere blends and their impact on bioadhesion and drug delivery in vitro.

  Biomaterials 20030901

• Auditory nerve fibre responses to salicylate revisited.

  Hearing research 20030901

• [The electro-physiological change of guinea pig cochlea caused by intracochlear perfusion of sodium salicylate].

  Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20030901

• A high performance liquid chromatography method for determination of gas-phase hydrogen peroxide in ambient air using Fenton's chemistry.

  Chemosphere 20030801

• Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK.

  International journal of oncology 20030801

• Identification of sodium salicylate as an hsp inducer using a simple screening system for stress response modulators in mammalian cells.

  European journal of biochemistry 20030801

• Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival.

  Blood 20030701

• Sodium salicylate inhibits expression of COX-2 through suppression of ERK and subsequent NF-kappaB activation in rat ventricular cardiomyocytes.

  Archives of pharmacal research 20030701

• A behavioral paradigm to judge acute sodium salicylate-induced sound experience in rats: a new approach for an animal model on tinnitus.

  Hearing research 20030601

• Aspirin and other cyclooxygenase inhibitors: new therapeutic insights.

  Seminars in vascular medicine 20030501

• Expression of NF-kappaB in epidermis and the relationship between NF-kappaB activation and inhibition of keratinocyte growth.

  The British journal of dermatology 20030401

• Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit vascular smooth muscle cell proliferation via differential effects on the cell cycle.

  The Journal of pharmacy and pharmacology 20030401

• Non-steroidal anti-inflammatory drug sodium salicylate, but not diclofenac or celecoxib, protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats.

  Brain research 20030321

• Molecular ordering of ROS production, mitochondrial changes, and caspase activation during sodium salicylate-induced apoptosis.

  Free radical biology & medicine 20030215

• Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.

  The Journal of pharmacology and experimental therapeutics 20030201

• Urate transport via human PAH transporter hOAT1 and its gene structure.

  Kidney international 20030101

• Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20030101

• Intraperitoneal administration of salicylate dose-dependently prevents stress-induced ulcer formation in rats.

  Polish journal of pharmacology 20030101

• Isolation and characterisation of new Planococcus sp. strain able for aromatic hydrocarbons degradation.

  Acta microbiologica Polonica 20030101

• Disposition of sodium salicylate, flunixin and meloxicam after intravenous administration in broiler chickens.

  Journal of veterinary pharmacology and therapeutics 20021201

• Inhibitory effects of sodium salicylate and acetylsalicylic acid on UVB-induced mouse skin carcinogenesis.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20021201

• Effects of nimodipine on salicylate ototoxicity.

  The Annals of otology, rhinology, and laryngology 20021201

• Aspirin and sodium salicylate inhibit proliferation and induce apoptosis in rheumatoid synovial cells.

  The Journal of pharmacy and pharmacology 20021201

• [Effects of salicylate on the capillary permeability of inner ear in guinea pigs].

  Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20021201

• Attenuation of iminodipropionitrile induced behavioral syndrome by sodium salicylate in rats.

  Pharmacology, biochemistry, and behavior 20021001

• Enhancement effects of double-chained cationic surfactants of n-dimethyldialkylammoniums on permeability of salicylate through guinea pig dorsal skin.

  Chemical & pharmaceutical bulletin 20021001

• Invited comment on W. Ebstein: On the therapy of diabetes mellitus, in particular on the application of sodium salicylate.

  Journal of molecular medicine (Berlin, Germany) 20021001

• The multidrug efflux pump NorA is not required for salicylate-induced reduction in drug accumulation by Staphylococcus aureus.

  International journal of antimicrobial agents 20020901

• Suppression of Japanese encephalitis virus infection by non-steroidal anti-inflammatory drugs.

  The Journal of general virology 20020801

• Anti-inflammatory effects of aspirin and sodium salicylate.

  European journal of pharmacology 20020628

• Degradation of and drug release from a novel 2,2-bis(2-oxazoline) linked poly(lactic acid) polymer.

  Journal of controlled release : official journal of the Controlled Release Society 20020617

• Role of ATP-sensitive potassium channels in prostaglandin-mediated gastroprotection in the rat.

  The Journal of pharmacology and experimental therapeutics 20020601

• Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function.

  Diabetes 20020601

• Activation of p38 mitogen-activated protein kinase and nuclear factor-kappaB in tumour necrosis factor-induced eotaxin release of human eosinophils.

  Clinical and experimental immunology 20020601

• Differential cytostatic effect of sodium salicylate in human colorectal cancers using an individualized histoculture system.

  Cancer chemotherapy and pharmacology 20020601

• Sodium salicylate-triggered apoptosis in HL-60 cells depends on caspase-8 activation.

  International journal of hematology 20020501

• Effect of bioadhesive polymers, sodium salicylate, polyoxyethylene-9-lauryl ether, and method of preparation on the relative hypoglycemia produced by insulin enteric-coated capsules in diabetic beagle dogs.

  Drug development and industrial pharmacy 20020501

• Oral delivery of insulin from enteric-coated capsules containing sodium salicylate: effect on relative hypoglycemia of diabetic beagle dogs.

  International journal of pharmaceutics 20020426

• Selective inhibition of STAT3 phosphorylation by sodium salicylate in cardiac fibroblasts.

  Biochemical pharmacology 20020401

• Inhibition of p-cresol on aerobic biodegradation of carbazole, and sodium salicylate by Pseudomonas putida.

  Water research 20020401

• NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells.

  Biochemical and biophysical research communications 20020308

• Aspirin and salicylates inhibit the IL-4- and IL-13-induced activation of STAT6.

  Journal of immunology (Baltimore, Md. : 1950) 20020201

• Iron (III) attenuates hydroxyl radical generation accompanying non-enzymatic oxidation of noradrenaline in the rat heart.

  Naunyn-Schmiedeberg's archives of pharmacology 20020201

• [Effects of sodium salicylate and extracellular K(+) on outward potassium current and resting potential of outer hair cell isolated from guinea pig cochlea].

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20020201

• Targeting of salicylate to skin and muscle following topical injections in rats.

  International journal of pharmaceutics 20020114

• Interaction of cyclooxygenase-2 inhibitors and salicylate in gastric mucosal damage.

  European journal of pharmacology 20020102

• NF-kappa B DNA-binding activity in embryos responding to a teratogen, cyclophosphamide.

  BMC developmental biology 20020101

• Effect of bio-adhesive polymers, sodium salicylate, polyoxyethylene-9-lauryl ether and method of preparation on the relative hypoglycemia produced by insulin enteric coated capsules in diabetic beagle dogs.

  Bollettino chimico farmaceutico 20020101

• A comparison of biodegradation of phenol and homologous compounds by Pseudomonas vesicularis and Staphylococcus sciuri strains.

  Acta microbiologica Polonica 20020101

• Sodium salicylate enhances the expression of cyclooxygenase-2 in endotoxin-stimulated human mononuclear cells.

  European journal of pharmacology 20011214

• Sodium salicylate inhibits prostaglandin formation without affecting the induction of cyclooxygenase-2 by bacterial lipopolysaccharide in vivo.

  The Journal of pharmacology and experimental therapeutics 20011201

• Activation of HIV in human skin by ultraviolet B radiation and its inhibition by NFkappaB blocking agents.

  Photochemistry and photobiology 20011201

• Aspirin and salicylate bind to immunoglobulin heavy chain binding protein (BiP) and inhibit its ATPase activity in human fibroblasts.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101

• Relative hypoglycemic effect of insulin suppositories in diabetic beagle dogs: optimization of various concentrations of sodium salicylate and polyoxyethylene-9-lauryl ether.

  Biological & pharmaceutical bulletin 20011101

• Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-kappaB activation in HeLa cells occur via a mechanism involving p38 MAP kinase.

  Cancer research 20011015

• Effect of salicylate and short-term sound exposure on extracochlear electrically-evoked otoacoustic emissions.

  Acta oto-laryngologica 20011001

• [Structural and functional changes in sympathetic ganglia following endotoxin and alpha1-antitrypsin exposure].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20011001

• [Changes in the afferent activity of the vagus nerve and the rectal temperature in rats following Escherichia coli endotoxin administration].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20011001

• Effect of media composition on yield values of bacteria growing on binary and ternary substrate mixtures in continuous culture.

  Biotechnology and bioengineering 20010905

• Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta.

  Science (New York, N.Y.) 20010831

• The contribution of NF-kappa B activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors.

  Blood 20010815

• FT-Raman, FT-IR and surface enhanced Raman scattering spectra of sodium salicylate.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20010701

• Selective suppression of CCAAT/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts.

  The Journal of biological chemistry 20010601

• Acanthoamoeba attachment to contact lenses.

  Ophthalmology 20010501

• Sodium salicylate increases CYP2E1 levels and enhances arachidonic acid toxicity in HepG2 cells and cultured rat hepatocytes.

  Molecular pharmacology 20010401

• Salicylates inhibit T cell adhesion on endothelium under nonstatic conditions: induction of L-selectin shedding by a tyrosine kinase-dependent mechanism.

  Journal of immunology (Baltimore, Md. : 1950) 20010115

• Salicylate and cocaine: interactive toxicity during chicken mid-embryogenesis.

  Free radical biology & medicine 20010115

• The possibility of achieving an interactive mixture with high dose homogeneity containing an extremely low proportion of a micronised drug.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010101

• Increases in the mutation frequency at which fusidic acid-resistant Staphylococcus aureus arise with salicylate.

  Journal of medical microbiology 20010101

• Quantitative analysis of hydroxyl radicals in the anterior optic nerve of the cat following transient ischemia.

  Ophthalmic surgery and lasers 20010101

• Increased sensitivity to sodium salicylate-induced apoptosis in drug-resistant leukemia L1210 cells.

  Anticancer research 20010101

• Preparation of regular sized Ca-alginate microspheres using membrane emulsification method.

  Journal of microencapsulation 20010101

• Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen.

  The Journal of biological chemistry 20001208

• Acetaminophen inhibits iNOS gene expression in RAW 264.7 macrophages: differential regulation of NF-kappaB by acetaminophen and salicylates.

  Biochemical and biophysical research communications 20000616

• Inhibition of carrageenan-induced edema by indomethacin or sodium salicylate does not prevent the increase of nerve growth factor in the rat hind paw.

  Neuroscience letters 20000114

• Sulindac inhibits activation of the NF-kappaB pathway.

  The Journal of biological chemistry 19990917

• Sodium salicylate inhibits macrophage TNF-alpha production and alters MAPK activation.

  The Journal of surgical research 19990615

• Induction of stromelysin gene expression by tumor necrosis factor alpha is inhibited by dexamethasone, salicylate, and N-acetylcysteine in synovial fibroblasts.

  The Journal of pharmacology and experimental therapeutics 19990601

• Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes.

  Cytokine 19990501

• Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate.

  Proceedings of the National Academy of Sciences of the United States of America 19990427

• Sodium salicylate activates caspases and induces apoptosis of myeloid leukemia cell lines.

  Blood 19990401

• Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells.

  Blood 19980815

• Induction of the DNA-binding and transcriptional activities of heat shock factor 1 is uncoupled in Xenopus oocytes.

  Biochimica et biophysica acta 19980312

• Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages.

  Molecular pharmacology 19970901

• Differential damage to auditory neurons and hair cells by ototoxins and neuroprotection by specific neurotrophins in rat cochlear organotypic cultures.

  The European journal of neuroscience 19960901

• Inhibition of NF-kappa B by sodium salicylate and aspirin.

  Science (New York, N.Y.) 19940812

• Sodium salicylate sensitivity in an asthmatic patient with aspirin sensitivity.

  Journal of Korean medical science 19910601

• Differential effects of non-steroidal anti-inflammatory drugs on seizures produced by pilocarpine in rats.

  Brain research 19881018

• Temporary hearing loss induced by combinations of intense sounds and nonsteroidal anti-inflammatory drugs.

  American journal of otolaryngology 19840101

• Therapeutic attempts in infants with nonketotic hyperglycinaemia.

  Journal of mental deficiency research 19810301

• Effect of myocardial ischaemia and antilipolytic agents on lipolysis and fatty acid metabolism in the in situ dog heart.

  Scandinavian journal of clinical and laboratory investigation 19791001

• Comparative nephrotoxicity of aspirin and phenacetin derivatives.

  British medical journal 19711127