5445-51-2 | H2cbdca

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$8.00	$5.00
25g	98%	in stock	$20.00	$14.00

Description

• Catalog Number: AI52223
• Chemical Name: H2cbdca
• CAS Number: 5445-51-2
• Molecular Formula: C6H8O4
• Molecular Weight: 144.1253
• MDL Number: MFCD00001325
• SMILES: OC(=O)C1(CCC1)C(=O)O
• NSC Number: 22073

Computed Properties

• Complexity: 164
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: 0.4

Literature

• Antitumor carboplatin is more toxic in tumor cells when photoactivated: enhanced DNA binding.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20120801

• A phase I/II study of carboplatin plus gemcitabine for elderly patients with advanced non-small cell lung cancer: West Japan Thoracic Oncology Group Trial (WJTOG) 2905.

  Lung cancer (Amsterdam, Netherlands) 20120701

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  Gan to kagaku ryoho. Cancer & chemotherapy 20120601

• Evaluation of a formula for individual dosage of nedaplatin based on renal function.

  Cancer chemotherapy and pharmacology 20120301

• [A case of stage IVb cervical carcinoma in which survival was prolonged by two different chemotherapies and CCRT].

  Gan to kagaku ryoho. Cancer & chemotherapy 20120301

• Present status and problems on molecular targeted therapy of cancer.

  Cancer research and treatment : official journal of Korean Cancer Association 20120301

• Synthesis, antiproliferative activity and estrogen receptor α affinity of novel estradiol-linked platinum(II) complex analogs to carboplatin and oxaliplatin. Potential vector complexes to target estrogen-dependent tissues.

  European journal of medicinal chemistry 20120201

• 4-Carboxypiperidinium 1-carboxycyclobutane-1-carboxylate.

  Acta crystallographica. Section C, Crystal structure communications 20120201

• Copper-transporting P-type adenosine triphosphatase (ATP7A) is associated with platinum-resistance in non-small cell lung cancer (NSCLC).

  Journal of translational medicine 20120101

• A phase II study of first-line chemotherapy with weekly carboplatin plus gemcitabine in advanced non-small cell lung cancer.

  Chemotherapy 20120101

• Hypotension due to Chemotherapy in a Patient with Small Cell Lung Cancer and Lambert-Eaton Myasthenic Syndrome Undergoing Hemodialysis: A First Case Report.

  Case reports in oncology 20120101

• Are platinum agents, paclitaxel and irinotecan effective for clear cell carcinoma of the ovary? DNA damage detected with γH2AX induced by anticancer agents.

  Journal of ovarian research 20120101

• [The clinical effect of combination therapy for oral cancer with S-1, superselective intra-arterial chemotherapy, and radiation therapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20111201

• Dicarboxylate-bridged (Mo2)n (n = 2, 3, 4) paddle-wheel complexes: potential intermediate building blocks for metal-organic frameworks.

  Dalton transactions (Cambridge, England : 2003) 20111121

• Synthesis of novel β-aminocyclobutanecarboxylic acid derivatives by a solvent-free aza-Michael addition and subsequent ring closure.

  Organic & biomolecular chemistry 20111021

• [Poorly-differentiated neuroendocrine carcinoma of ascending colon with liver metastases successfully treated with carboplatin and etoposide].

  Gan to kagaku ryoho. Cancer & chemotherapy 20110701

• Antiangiogenic agents in combination with chemotherapy in patients with advanced non-small cell lung cancer.

  Cancer investigation 20110501

• Expression of TGFß1 and its receptors is associated with biological features of ovarian cancer and sensitivity to paclitaxel/carboplatin.

  Oncology reports 20110401

• Risk factors contributing to the development of carboplatin-related delayed hypersensitivity reactions in Japanese patients with gynecologic cancers.

  Cancer chemotherapy and pharmacology 20110201

• Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110101

• Clinical responses to EGFR-tyrosine kinase inhibitor retreatment in non-small cell lung cancer patients who benefited from prior effective gefitinib therapy: a retrospective analysis.

  BMC cancer 20110101

• Review of the management of relapsed small-cell lung cancer with amrubicin hydrochloride.

  Clinical Medicine Insights. Oncology 20110101

• Epithelial thymic tumours in paediatric age: a report from the TREP project.

  Orphanet journal of rare diseases 20110101

• Platinum agent-induced hypersensitivity reactions: data mining of the public version of the FDA adverse event reporting system, AERS.

  International journal of medical sciences 20110101

• Gemcitabine: efficacy in the treatment of advanced stage nonsquamous non-small cell lung cancer.

  Clinical Medicine Insights. Oncology 20110101

• One-dimensional hydrogen-bonded infinite chain from nickel(II) tetraaza macrocyclic complex and 1,2-cyclopentanedicarboxylate ligand.

  International journal of molecular sciences 20110101

• Nab-paclitaxel for the treatment of breast cancer: efficacy, safety, and approval.

  OncoTargets and therapy 20110101

• Adverse event profiles of platinum agents: data mining of the public version of the FDA adverse event reporting system, AERS, and reproducibility of clinical observations.

  International journal of medical sciences 20110101

• DNA Interaction Studies of a New Platinum(II) Complex Containing Different Aromatic Dinitrogen Ligands.

  Bioinorganic chemistry and applications 20110101

• Neurotoxicity caused by the treatment with platinum analogues.

  Chemotherapy research and practice 20110101

• Unprecedented water addition to the α,β-unsaturated enone bond, mediated by the combination of carbonate and platinum(II).

  Chemistry (Weinheim an der Bergstrasse, Germany) 20101115

• Complex formation between Ru(η(6)-p-cym)(H2O)3]2+ and (O,O) donor ligands with biological relevance in aqueous solution.

  Dalton transactions (Cambridge, England : 2003) 20101114

• A randomized phase II trial of adjuvant chemotherapy with bi-weekly carboplatin plus paclitaxel versus carboplatin plus gemcitabine in patients with completely resected non-small cell lung cancer.

  Anticancer research 20101101

• Phase II trial of adjuvant chemotherapy with bi-weekly carboplatin plus paclitaxel in patients with completely resected non-small cell lung cancer.

  Anticancer research 20100701

• Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs.

  British journal of cancer 20100629

• In vitro ruthenation of human breast cancer suppressor gene 1 (BRCA1) by the antimetastasis compound RAPTA-C and its analogue CarboRAPTA-C.

  Chemistry & biodiversity 20100501

• Carboplatin and etoposide combined with radiotherapy for limited-stage small-cell esophageal carcinoma: three cases and review of the literature.

  Japanese journal of radiology 20100401

• Improved outcome of central nervous system germ cell tumors: implications for the role of risk-adapted intensive chemotherapy.

  Journal of Korean medical science 20100301

• Treatment for recurrent ovarian cancer-at first relapse.

  Journal of oncology 20100101

• [Combination chemotherapy with gemcitabine and paclitaxel in a hemodialysis patient with metastatic urothelial carcinoma].

  Hinyokika kiyo. Acta urologica Japonica 20100101

• Anti-tumor effects of CIK combined with oxaliplatin in human oxaliplatin-resistant gastric cancer cells in vivo and in vitro.

  Journal of experimental & clinical cancer research : CR 20100101

• Vitamin D in combination cancer treatment.

  Journal of Cancer 20100101

• Hypersensitivity reactions associated with platinum antineoplastic agents: a systematic review.

  Metal-based drugs 20100101

• Genetic polymorphisms in the endothelial nitric oxide synthase gene correlate with overall survival in advanced non-small-cell lung cancer patients treated with platinum-based doublet chemotherapy.

  BMC medical genetics 20100101

• A phase II study of cisplatin and irinotecan as induction chemotherapy followed by accelerated hyperfractionated thoracic radiotherapy with daily low-dose carboplatin in unresectable stage III non-small cell lung cancer: JCOG 9510.

  Japanese journal of clinical oncology 20091201

• Tumor platinum concentration following intraperitoneal administration of cisplatin versus carboplatin in an ovarian cancer model.

  Gynecologic oncology 20091201

• Relevance of the leaving group for antitumor activity of new platinum(II) compounds containing anthracene derivatives as a carrier ligand.

  Journal of inorganic biochemistry 20091201

• [Experience of postoperative adjuvant chemotherapy of lung cancer at outpatient department].

  Kyobu geka. The Japanese journal of thoracic surgery 20091201

• [Clinical evaluation of calculating carboplatin doses using modification of diet in renal disease (MDRD) estimate and adverse events].

  Gan to kagaku ryoho. Cancer & chemotherapy 20091201

• [A case of bronchogenic carcinoma which obtained long-term relapse free survival by argon plasma coagulation].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20091201

• Fasting and cancer treatment in humans: A case series report.

  Aging 20091201

• [Advanced lung cancer with mediastinal lymph node metastasis and recurrence of brain metastasis completely responsive to combination chemotherapy and gamma knife radiosurgery--a case report].

  Gan to kagaku ryoho. Cancer & chemotherapy 20091101

• [Neoadjuvant chemotherapy with intraperitoneal paclitaxel for advanced gynecologic cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20091101

• Analysis of feasibility and toxicity of concurrent chemoradiotherapy with S-1 for locally advanced squamous cell carcinoma of the head and neck in elderly cases and/or cases with comorbidity.

  Cancer chemotherapy and pharmacology 20091001

• Results of a preliminary study using hypofractionated involved-field radiation therapy and concurrent carboplatin/paclitaxel in the treatment of locally advanced non-small-cell lung cancer.

  International journal of clinical oncology 20091001

• A phase I study of gemcitabine and carboplatin in patients with advanced non-small cell lung cancer and a performance status of 2.

  Japanese journal of clinical oncology 20090901

• [Appropriate hemodialysis scheduling based on therapeutic drug monitoring of carboplatin in a patient with lung cancer and chronic renal failure].

  Gan to kagaku ryoho. Cancer & chemotherapy 20090901

• [A case of advanced non-small-cell lung cancer successfully treated with S-1 plus CBDCA after multiple chemotherapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20090901

• Phase I/II study of S-1 plus carboplatin in patients with advanced non-small cell lung cancer.

  European journal of cancer (Oxford, England : 1990) 20090801

• Synthesis of stable platinum complexes containing carborane in a carrier group for potential BNCT agents.

  Dalton transactions (Cambridge, England : 2003) 20090707

• Copper transporter 2 regulates the cellular accumulation and cytotoxicity of Cisplatin and Carboplatin.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090701

• Phase II study of oral vinorelbine in combination with carboplatin followed by consolidation therapy with oral vinorelbine as single-agent in unresectable localized or metastatic non-small cell lung carcinoma.

  Lung cancer (Amsterdam, Netherlands) 20090601

• [CDDP+CPT-11 therapy is useful for stage IVb esophageal small cell carcinoma].

  Gan to kagaku ryoho. Cancer & chemotherapy 20090501

• The role of the mammalian copper transporter 1 in the cellular accumulation of platinum-based drugs.

  Molecular pharmacology 20090201

• Enhanced apoptotic effect of combined modality of 9-hydroxypheophorbide alpha-mediated photodynamic therapy and carboplatin on AMC-HN-3 human head and neck cancer cells.

  Oncology reports 20090201

• Circulating endothelial cells in non-small cell lung cancer patients treated with carboplatin and paclitaxel.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20090201

• Primary small cell carcinoma of the breast.

  Breast cancer (Tokyo, Japan) 20090101

• Enhancing the efficacy of cisplatin in ovarian cancer treatment - could arsenic have a role.

  Journal of ovarian research 20090101

• [Feasibility and response of gemcitabine and carboplatin biweekly combination chemotherapy for patients with postoperative recurrence non-small cell lung cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20090101

• In Vitro Evaluation of Oxoplatin: An Oral Platinum(IV) Anticancer Agent.

  Metal-based drugs 20090101

• Equilibrium and kinetic investigations of the interaction of model platinum(II) complex with DNA constituents in reference to the antitumour activity: complex-formation reactions of [Pd(N,N-diethylethylenediamine)(H2O)2]2+ with ligands of biological significance and displacement reactions of DNA constituents.

  Bioinorganic chemistry and applications 20090101

• Malignant pleural mesothelioma with long-term tumor disappearance of a local relapse after surgery: a case report.

  Journal of medical case reports 20090101

• Non-Cross Resistant Sequential Single Agent Chemotherapy in First-Line Advanced Non-Small Cell Lung Cancer Patients: Results of a Phase II Study.

  Journal of oncology 20090101

• The ubiquitin-proteasome system as a molecular target in solid tumors: an update on bortezomib.

  OncoTargets and therapy 20090101

• In vitro-chemosensitivity test using the collagen gel droplet embedded culture drug test (CD-DST) for malignant pleural mesothelioma: possibility of clinical application.

  Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20081201

• Synthesis and anticancer activity of [2-hydroxy-1,3-diaminopropane-kappa 2N,N'] platinum(II) complexes.

  Journal of inorganic biochemistry 20081001

• c-Jun-NH2-terminal kinase potentiates apoptotic cell death in response to carboplatin in B lymphoma cells.

  Cancer chemotherapy and pharmacology 20080901

• [Study of the predictive method of 24-hour creatinine clearance in calculating the appropriate dosage of Carboplatin].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080801

• Treatment results of continuous intra-arterial CBDCA infusion chemotherapy in combination with radiation therapy for locally advanced tongue cancer.

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20080601

• [A long-surviving patient with lung pleomorphic carcinoma treated with postoperative carboplatin and paclitaxel combination chemotherapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20080601

• Preparation, characterization and in vitro anticancer activity of platinum(II) complexes with N-Cyclohexyl-1,3-propanediamine as the carrier.

  Chemical & pharmaceutical bulletin 20080501

• Influence of the anionic ligands on the anticancer activity of Ru(II)-dmso complexes: Kinetics of aquation and in vitro cytotoxicity of new dicarboxylate compounds in comparison with their chloride precursors.

  Journal of inorganic biochemistry 20080401

• In vitro gene expression analysis of nephrotoxic drugs in rat primary renal cortical tubular cells.

  Journal of applied toxicology : JAT 20080301

• [A case of multidrug-resistant squamous cell lung carcinoma responding to S-1 plus CPT-11 combination chemotherapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20080301

• Importance of platinum(II)-assisted platinum(IV) substitution for the oxidation of guanosine derivatives by platinum(IV) complexes.

  Inorganic chemistry 20080218

• Synthesis and cytotoxicity of platinum(II) complexes of a physiologically active carrier histamine.

  Archiv der Pharmazie 20080201

• Feasibility trial of adjuvant chemotherapy with paclitaxel and carboplatin after surgical resection in Japanese patients with non-small cell lung cancer: report of the Lung Oncology Group in Kyushu (LOGIK) protocol 0501.

  General thoracic and cardiovascular surgery 20080201

• [Adjuvant concurrent chemoradiotherapy for resected locally advanced lung cancer outpatients].

  Kyobu geka. The Japanese journal of thoracic surgery 20080101

• Analysis of the pattern of hypersensitivity reactions in patients receiving carboplatin retreatment for recurrent ovarian cancer.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20080101

• Carboplatin-induced gene expression changes in vitro are prognostic of survival in epithelial ovarian cancer.

  BMC medical genomics 20080101

• Chemoradiation therapy using radiotherapy, systemic chemotherapy with 5-fluorouracil and nedaplatin, and intra-arterial infusion using carboplatin for locally advanced head and neck cancer - Phase II study.

  Oral oncology 20071101

• Free radical-induced redox chemistry of platinum-containing anti-cancer drugs.

  Radiation research 20071001

• [Safety evaluation of adjuvant chemotherapy by weekly paclitaxel combined with weekly carboplatin in patients with postoperative non-small cell lung cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20070901

• Combined evaluation of Rad51 and ERCC1 expressions for sensitivity to platinum agents in non-small cell lung cancer.

  International journal of cancer 20070815

• The combined effects of multiple chemotherapeutic agents for malignant glioma cells.

  Journal of neuro-oncology 20070801

• Role of carbonate in the cytotoxicity of carboplatin.

  Chemical research in toxicology 20070601

• Phase-II study of docetaxel, estramustine phosphate, and carboplatin in patients with hormone-refractory prostate cancer.

  European urology 20070501

• [A case of postoperative multiple pulmonary metastases of non-small-cell lung cancer successfully treated with S-1].

  Gan to kagaku ryoho. Cancer & chemotherapy 20070501

• [A case of advanced clear cell carcinoma of the endometrium that responded remarkably to neoadjuvant chemotherapy of combination carboplatin plus weekly paclitaxel].

  Gan to kagaku ryoho. Cancer & chemotherapy 20070301

• [A case of meningeal carcinomatosis from lung cancer successfully treated with aggressive multimodal therapy].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20070301

• A phase I and pharmacokinetic study of indisulam in combination with carboplatin.

  British journal of cancer 20070226

• Phase I trial of paclitaxel, doxorubicin, and carboplatin (TAC) for the treatment of endometrial cancer.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20070101

• Phase II trial of carboplatin and infusional cyclosporine with alpha-interferon in recurrent ovarian cancer: a California Cancer Consortium Trial.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20070101

• Clinical benefit of readministration of gefitinib for initial gefitinib-responders with non-small cell lung cancer.

  BMC cancer 20070101

• Phase I study of paclitaxel, carboplatin and UFT in chemo-naive patients with advanced non-small cell lung cancer (NSCLC).

  Medical oncology (Northwood, London, England) 20070101

• Radiation reduces carboplatin sensitivity and enhances nedaplatin sensitivity in cervical squamous cell carcinoma in vitro.

  European journal of gynaecological oncology 20070101

• DNA-metallodrugs interactions signaled by electrochemical biosensors: an overview.

  Bioinorganic chemistry and applications 20070101

• Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.

  Analytical chemistry 20061215

• Hyperthermia combined with intra-thoracic chemotherapy and radiotherapy for malignant pleural mesothelioma.

  International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20061101

• [An advanced pulmonary adenocarcinoma case in which TS-1 proved effective].

  Gan to kagaku ryoho. Cancer & chemotherapy 20061101

• Combined effects of diamines and carboxylate bridges on structural and magnetic properties of a series of polynuclear copper(II) complexes with 1,1-cyclobutanedicarboxylic acid.

  Inorganic chemistry 20061002

• Contribution of the major copper influx transporter CTR1 to the cellular accumulation of cisplatin, carboplatin, and oxaliplatin.

  Molecular pharmacology 20061001

• [Combined chemotherapy with weekly paclitaxel and carboplatin for recurrent and refractory epithelial ovarian cancer--phase I study].

  Gan to kagaku ryoho. Cancer & chemotherapy 20061001

• [Adjuvant chemotherapy of paclitaxel plus carboplatin in uterine corpus cancer--comparison with cisplatin, adriamycin plus cyclophosphamide].

  Gan to kagaku ryoho. Cancer & chemotherapy 20060701

• [A case of malignant peritoneal mesothelioma successfully treated with carboplatin and paclitaxel].

  Gan to kagaku ryoho. Cancer & chemotherapy 20060701

• Treatment strategy for recurrent and refractory epithelial ovarian cancer: efficacy of high-dose chemotherapy with hematopoietic stem cell transplantation.

  Acta histochemica et cytochemica 20060701

• A phase II study of single-agent gefitinib as first-line therapy in patients with stage IV non-small-cell lung cancer.

  British journal of cancer 20060605

• In vitro sensitivity to platinum-derived drugs is associated with expression of thymidylate synthase and dihydropyrimidine dehydrogenase in human lung cancer.

  Oncology reports 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• [A case of a second cancer of metachronous multiple primary non-small cell lung cancer successfully treated with TS-1 and CDDP chemotherapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20060501

• Dose individualization of carboplatin after a 120-hour infusion schedule: higher dose intensity but fewer toxicities.

  Therapeutic drug monitoring 20060401

• Activation of carboplatin by carbonate.

  Chemical research in toxicology 20060101

• Studies on the synthesis, characterization, binding with DNA and activities of two cis-planaramineplatinum(II) complexes of the form: cis-PtL(NH3)Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine.

  BMC chemical biology 20060101

• Evaluation of combined nedaplatin and docetaxel therapy for human head and neck cancer in vivo.

  Anticancer research 20060101

• Ex vivo chemosensitivity of head and neck carcinoma to cytostatic drug combinations.

  Anticancer research 20060101

• Anticancer drug clustering in lung cancer based on gene expression profiles and sensitivity database.

  BMC cancer 20060101

• Persistent and aggressive treatment for thymic carcinoma. Results of a single-institute experience with 25 patients.

  Oncology 20060101

• Treatment of peritoneal carcinomatosis using carboplatin-loaded hydroxyapatite particles.

  Anticancer research 20060101

• The unprecedented bridging coordination mode of 1,1-cyclobutane dicarboxylate (mu-cbdc-O,O') stabilized by intramolecular hydrogen bonds in ruthenium(II) complexes.

  Dalton transactions (Cambridge, England : 2003) 20051221

• Down-regulation of O6-methylguanine-DNA methyltransferase gene expression in gliomas by platinum compounds.

  Oncology reports 20051101

• A phase I and pharmacokinetic study of the selective, non-peptidic inhibitor of matrix metalloproteinase BAY 12-9566 in combination with etoposide and carboplatin.

  Anti-cancer drugs 20051001

• [Effect of intraperitoneal chemotherapy on experimental peritoneal dissemination of gastric cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20051001

• Post-operative adjuvant chemoradiotherapy with carboplatin and 5-fluorouracil for primary branchiogenic carcinoma.

  The Journal of laryngology and otology 20050601

• Patterns of care survey (PCS) in lung cancer: how well does current U.S. practice with chemotherapy in the non-metastatic setting follow the literature?

  Lung cancer (Amsterdam, Netherlands) 20050401

• [Weekly paclitaxel administration and intraabdominal CBDCA injection possibly beneficial treatment for recurrent breast cancer associated with metastatic ovarian cancer and peritoneal dissemination after operation--a case report].

  Gan to kagaku ryoho. Cancer & chemotherapy 20050301

• [Superselective intraarterial chemotherapy using low dose CBDCA and Pirarubicin with concurrent radiotherapy for head and neck cancer].

  Nihon Jibiinkoka Gakkai kaiho 20050301

• Etodolac, a selective cyclo-oxygenase-2 inhibitor, enhances carboplatin-induced apoptosis of human tongue carcinoma cells by down-regulation of FAP-1 expression.

  Oral oncology 20050101

• Copper transporters regulate the cellular pharmacology and sensitivity to Pt drugs.

  Critical reviews in oncology/hematology 20050101

• Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20050101

• Germ cell testicular tumors in clinical stage A and normal values of serum tumor mark-ers post-orchiectomy: the experience in the management of 300 consecutive patients.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20050101

• Synergistic interaction between a novel mixed ligand copper(II) chelate complex and a panel of anticancer agents in T47D human breast cancer cells in vitro.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20050101

• Preliminary results of a phase II study of weekly paclitaxel (PTX) and carboplatin (CBDCA) administered concurrently with thoracic radiation therapy (TRT) followed by consolidation chemotherapy with PTX/CBDCA for stage III unresectable non-small-cell lung cancer (NSCLC).

  American journal of clinical oncology 20041201

• Immunohistochemical metallothionein expression in hepatocellular carcinoma: relation to tumor progression and chemoresistance to platinum agents.

  Journal of gastroenterology 20041201

• Establishment and characterization of a human ovarian small cell carcinoma, hypercalcemic type, cell line (OS-1) secreting PTH, PthrP and ACTH--special reference to the susceptibility of anti-cancer drugs.

  Human cell 20041201

• Phase II trial of carboplatin and infusional cyclosporine in platinum-resistant recurrent ovarian cancer.

  Cancer chemotherapy and pharmacology 20041001

• Phase I-II study of irinotecan (CPT-11) plus nedaplatin (254-S) with recombinant human granulocyte colony-stimulating factor support in patients with advanced or recurrent cervical cancer.

  British journal of cancer 20040913

• Radiation therapy with or without concurrent low-dose daily chemotherapy in locally advanced, nonmetastatic squamous cell carcinoma of the head and neck.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040901

• [Advanced non-small cell lung cancer responded to both vinorelbine and carboplatin over long-term outpatient treatment].

  Gan to kagaku ryoho. Cancer & chemotherapy 20040901

• AUC of Calvert's formula in targeted intra-arterial carboplatin chemoradiotherapy for cancer of the oral cavity.

  British journal of cancer 20040601

• [Paclitaxel plus carboplatin in ovarian cancer-comparison of adverse effects between monthly and weekly administration].

  Gan to kagaku ryoho. Cancer & chemotherapy 20040401

• Growth-inhibitory signals by activin A do not affect anticancer drug-sensitivity and acquired multi-drug-resistance in human ovarian endometrioid adenocarcinoma OVK-18 cells.

  Oncology reports 20040301

• Concurrent chemo-radiotherapy for nasopharyngeal carcinoma.

  Auris, nasus, larynx 20040301

• [Salvage combination chemotherapy with cytarabine, carboplatin and steroids for relapsed or refractory non-Hodgkin's lymphoma].

  Gan to kagaku ryoho. Cancer & chemotherapy 20040301

• [Outpatient chemotherapy and clinical pathway for non-small cell lung cancer].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20040301

• (2,2'-Bipyridine-kappa2N,N')(1,1-cyclobutanedicarboxylato-kappa2O,O')palladium(II), (1,1-cyclobutanedicarboxylato-kappa2O,O')(1,10-phenanthroline-kappa2N,N')palladium(II) monohydrate and (1,1-cyclobutanedicarboxylato-kappa2O,O')(1,10-phenanthroline-kappa2N,N')palladium(II) dihydrate.

  Acta crystallographica. Section C, Crystal structure communications 20040201

• Pharmacokinetic analysis of combination chemotherapy with carboplatin and etoposide in small-cell lung cancer patients undergoing hemodialysis.

  Annals of oncology : official journal of the European Society for Medical Oncology 20040101

• Improved targeting of platinum chemotherapeutics. the antitumour activity of the HPMA copolymer platinum agent AP5280 in murine tumour models.

  European journal of cancer (Oxford, England : 1990) 20040101

• Mechanisms of paclitaxel-induced apoptosis in an ovarian cancer cell line and its paclitaxel-resistant clone.

  Oncology 20040101

• Synthesis and biological activity of water-soluble maleimide derivatives of the anticancer drug carboplatin designed as albumin-binding prodrugs.

  Bioconjugate chemistry 20040101

• [A case of ovarian cancer with Parkinson's disease treated by combined chemotherapy with paclitaxel and carboplatin followed by surgery].

  Gan to kagaku ryoho. Cancer & chemotherapy 20031201

• Localised and unresectable neuroblastoma in infants: excellent outcome with low-dose primary chemotherapy.

  British journal of cancer 20031103

• Conformation of 2-aminomethylpyrrolidine and 2-aminomethylpiperidine in ternary platinum(II) complexes: regulation of conformation of the diamine by the coexisting ligand.

  Chemical & pharmaceutical bulletin 20031001

• [Evaluation of QOL with orally disintegrating antiemetic tablets in outpatient chemotherapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20031001

• Toward the design of novel polynuclear platinum antitumor complexes: a polydentate ligand system based on dipyridylamine and 1,3,5-trimethylenebenzene.

  Inorganic chemistry 20030922

• [Lung adenocarcinoma with multiple pulmonary metastases completely responsive to combination chemotherapy with carboplatin and weekly paclitaxel--a case report].

  Gan to kagaku ryoho. Cancer & chemotherapy 20030901

• Hypersensitivity reactions related to oxaliplatin (OHP).

  British journal of cancer 20030804

• The copper export pump ATP7B modulates the cellular pharmacology of carboplatin in ovarian carcinoma cells.

  Molecular pharmacology 20030801

• Carboplatin induces Fas (APO-1/CD95)-dependent apoptosis of human tongue carcinoma cells: sensitization for apoptosis by upregulation of FADD expression.

  International journal of cancer 20030710

• Impaired hydrolysis of cisplatin derivatives to aquated species prevents energy-dependent uptake in GLC4 cells resistant to cisplatin.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20030701

• First-line chemotherapy with epidoxorubicin, paclitaxel, and carboplatin for the treatment of advanced epithelial ovarian cancer patients.

  Gynecologic oncology 20030601

• Successful high-dose chemotherapy for widespread neuroaxis dissemination of an optico-hypothalamic juvenile pilocytic astrocytoma in an infant: a case report.

  Journal of neuro-oncology 20030501

• New cytotoxic and water-soluble bis(2-phenylazopyridine)ruthenium(II) complexes.

  Journal of medicinal chemistry 20030424

• Preclinical and clinical evaluation of four gemcitabine plus carboplatin schedules as front-line treatment for stage IV non-small-cell lung cancer.

  Annals of oncology : official journal of the European Society for Medical Oncology 20030201

• Maxillary cancer in a child: a case report.

  Auris, nasus, larynx 20030201

• Preparation, characterization, and antitumor activity of new cisplatin analogues with 1-methyl-4-(methylamino)piperidine: crystal structure of [PtII(1-methyl-4-(methylamino) piperidine)(oxalate)].

  Journal of inorganic biochemistry 20030201

• [Treatment results of patients over 3 years of age with medulloblastoma].

  Medycyna wieku rozwojowego 20030101

• Platinum agents in the treatment of osteosarcoma: efficacy of cisplatin vs. carboplatin in human osteosarcoma cell lines.

  Medical and pediatric oncology 20021201

• Phase II study of irinotecan and carboplatin for advanced non-small cell lung cancer.

  Lung cancer (Amsterdam, Netherlands) 20021201

• [A patient with mantle cell lymphoma who successfully underwent auto-PBSCT in combination with in vivo purging of tumor cells using rituximab].

  Gan to kagaku ryoho. Cancer & chemotherapy 20021201

• BcI-xL antisense treatment sensitizes Bcl-xL-overexpressing squamous cell carcinoma cells to carboplatin.

  Oral oncology 20021201

• [Combination chemotherapy of paclitaxel followed by nedaplatin for human ovarian cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20021101

• [Comparative clinical studies for head and neck cancer in Japan].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020901

• [Pilot study of an alternative CYVADIC + CBDCA protocol for adult soft tissue sarcoma as adjuvant chemotherapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020901

• A phase I and pharmacologic study of pyrazoloacridine (NSC 366140) and carboplatin in patients with advanced cancer.

  Investigational new drugs 20020801

• [Phase I study of biweekly paclitaxel and carboplatin administration in patients with advanced non-small cell lung cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020801

• Gemcitabine (GEM) and carboplatin (CBDCA) versus cisplatin (CDDP) and vinblastine (VLB) in advanced non-small-cell lung cancer (NSCLC) stages III and IV: a phase III randomised trial.

  Lung cancer (Amsterdam, Netherlands) 20020701

• [Therapy-related acute myeloid leukemia following double autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 20020601

• A prospective study of P-IMVP-16/CBDCA: a novel salvage chemotherapy for patients with aggressive non-Hodgkin's lymphoma who had previously received CHOP therapy as first-line chemotherapy.

  European journal of haematology 20020601

• Carboplatin induces less apoptosis in the cochlea of guinea pigs than cisplatin.

  Chemotherapy 20020501

• [Phase II study of combination therapy with paclitaxel and carboplatin against postoperative small residual disease in patients with stage I c-IV ovarian cancer--KCOG 989 trial].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020501

• Preparation and characterization of platinum(II) and (IV) complexes of 1,3-diaminepropane and 1,4-diaminebutane: circumvention of cisplatin resistance and DNA interstrand cross-link formation in CH1cisR ovarian tumor cells.

  Journal of medicinal chemistry 20020425

• Synthesis and selective tumor targeting properties of water soluble porphyrin-Pt(II) conjugates.

  Journal of inorganic biochemistry 20020410

• [Chemotherapy for small-cell lung cancer (SCLC) patients with renal failure].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020301

• [Cisplatin and carboplatin-induced ototoxicity in children: clinical aspects and perspectives for prevention].

  Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 20020201

• Bcl-x(L) confers multi-drug resistance in several squamous cell carcinoma cell lines.

  Oral oncology 20020101

• Comparisons of carboplatin and cisplatin as potentiators of 5-fluorouracil and radiotherapy in the mouse L1210 leukaemia model.

  Anticancer research 20020101

• First-line chemotherapy with vinorelbine, gemcitabine, and carboplatin in the treatment of brain metastases from non-small-cell lung cancer: a phase II study.

  Cancer investigation 20020101

• Carcinoma of the nasopharynx: analysis of treatment results in 91 patients.

  Acta oto-laryngologica. Supplementum 20020101

• Synthesis, characterization and antitumor activity of quinolone-platinum(II) conjugates.

  Journal of inorganic biochemistry 20011201

• Synthesis, characterization, DNA binding and cytotoxic studies of platinum(II) and palladium(II) complexes of the 2,2'-bipyridine and an anion of 1,1-cyclobutanedicarboxylic acid.

  Chemical & pharmaceutical bulletin 20011201

• Sequence-dependent antitumor efficacy of combination chemotherapy with nedaplatin, a newly developed platinum, and paclitaxel.

  Cancer letters 20011022

• [Effective combination chemotherapy using paclitaxel in the treatment of a small-cell lung cancer patient resistant to multiple drugs].

  Gan to kagaku ryoho. Cancer & chemotherapy 20011001

• Pharmacokinetic and pharmacodynamic analysis of combined chemotherapy with carboplatin and paclitaxel for patients with ovarian cancer.

  International journal of clinical oncology 20011001

• Association between expression of the MRP3 gene and exposure to platinum drugs in lung cancer.

  International journal of cancer 20010815

• [A case of pseudomyxoma peritonei treated successfully with intraperitoneal administration of CBDCA and etoposide, followed by local delivery of dextran with CDDP during surgery].

  Gan to kagaku ryoho. Cancer & chemotherapy 20010801

• [Feasibility, activity, and change in the level of blood paclitaxel concentration after weekly paclitaxel therapy for a patient with recurrent ovarian cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20010701

• [Combination chemotherapy of carboplatin and docetaxel for advanced non-small cell lung cancer (NSCLC)].

  Gan to kagaku ryoho. Cancer & chemotherapy 20010701

• Induction of cytochrome P450 3A4 by docetaxel in peripheral mononuclear cells and its expression in lung cancer.

  Cancer chemotherapy and pharmacology 20010701

• A pilot study of whole body hyperthermia and carboplatin in platinum-resistant ovarian cancer.

  European journal of cancer (Oxford, England : 1990) 20010601

• [A case of papillary adenocarcinoma of the ovary that responded favorably to irinotecan hydrochloride and cisplatin after the administration of paclitaxel and carboplatin].

  Gan to kagaku ryoho. Cancer & chemotherapy 20010601

• Drug interactions and cytotoxic effects of paclitaxel in combination with carboplatin, epirubicin, gemcitabine or vinorelbine in breast cancer cell lines and tumor samples.

  Breast cancer research and treatment 20010601

• An experimental study of the combined effect of radiotherapy and chemotherapy on head and neck squamous cell carcinoma cell line.

  Auris, nasus, larynx 20010501

• Concurrent chemotherapy and radiotherapy as initial treatment for stage II supraglottic squamous cell carcinoma.

  Auris, nasus, larynx 20010501

• [Dose finding study of paclitaxel and carboplatin for ovarian cancer (JKTB)].

  Gan to kagaku ryoho. Cancer & chemotherapy 20010401

• [Therapy-related myeloid leukemia following platinum-based chemotherapy for ovarian cancer].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 20010201

• Preclinical in vivo antitumor efficacy of nedaplatin with gemcitabine against human lung cancer.

  Japanese journal of cancer research : Gann 20010101

• Low dose carboplatin (AUC 4.5) combined with vinorelbine in the treatment of advanced non-small cell lung cancer: a single institution phase II study.

  Oncology reports 20010101

• [Refractory non-small-cell lung cancer responding to combination chemotherapy with docetaxel, gemcitabine and cisplatin].

  Gan to kagaku ryoho. Cancer & chemotherapy 20010101

• Effect of platinum coordination complex (PtCx) on citrate uptake by rat renal brush border membrane vesicles (BBMV): direct effect of carboplatin.

  Industrial health 20010101

• Successful autologous peripheral blood stem cell transplantation for relapsed intravascular lymphomatosis.

  Bone marrow transplantation 20010101

• Concurrent accelerated hyperfractionated radiation therapy and carboplatin/etoposide in patients with malignant glioma: long-term results of a phase II study.

  Journal of neuro-oncology 20010101

• Weekly dosing of carboplatin increases risk of allergy in children.

  Journal of pediatric hematology/oncology 20010101

• Primary chemotherapy in stage IV ovarian cancer. A prospective phase II study.

  European journal of gynaecological oncology 20010101

• Concurrent chemotherapy with carboplatin + 5-fluorouracil and radiotherapy in advanced squamous cell head and neck carcinoma: a retrospective single institution's study.

  Tumori 20010101

• Carboplatin AUC and gamma-glutamylcysteine synthetase gene expression in peripheral mononuclear cells of lung cancer patients.

  Anticancer research 20010101