545395-94-6 | Amg 9810

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$18.00	$12.00
5mg	98%	in stock	$32.00	$22.00
10mg	98%	in stock	$42.00	$29.00
50mg	98%	in stock	$108.00	$75.00
100mg	98%	in stock	$183.00	$128.00
250mg	98%	in stock	$310.00	$217.00
1g	98%	in stock	$832.00	$582.00

Description

• Catalog Number: AX38699
• Chemical Name: Amg 9810
• CAS Number: 545395-94-6
• Molecular Formula: C21H23NO3
• Molecular Weight: 337.41221999999993
• MDL Number: MFCD00955103
• SMILES: O=C(Nc1ccc2c(c1)OCCO2)/C=C/c1ccc(cc1)C(C)(C)C

Computed Properties

• Complexity: 474
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 4.6

Literature

• Effects of single swim stress on changes in TRPV1-mediated plasticity in the amygdala.

  Behavioural brain research 20130101

• Functional interactions between NMDA receptors and TRPV1 in trigeminal sensory neurons mediate mechanical hyperalgesia in the rat masseter muscle.

  Pain 20120701

• Structure-activity relationships of vanilloid receptor agonists for arteriolar TRPV1.

  British journal of pharmacology 20120301

• Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20111019

• The antinociceptive potency of N-arachidonoyl-dopamine (NADA) and its interaction with endomorphin-1 at the spinal level.

  Pharmacology, biochemistry, and behavior 20111001

• Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats.

  Pain 20110801

• TRPM3 is a nociceptor channel involved in the detection of noxious heat.

  Neuron 20110512

• TRPV1-antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling.

  Carcinogenesis 20110501

• Synergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammation.

  Gastroenterology 20110401

• Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath.

  European journal of pharmacology 20100901

• The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation.

  Pain 20100301

• Comparison of the peripheral mediator background of heat injury- and plantar incision-induced drop of the noxious heat threshold in the rat.

  Life sciences 20100213

• Pharmacologic antagonism of the oral aversive taste-directed response to capsaicin in a mouse brief access taste aversion assay.

  The Journal of pharmacology and experimental therapeutics 20100201

• Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia.

  Pain 20090801

• Differential effects of transient receptor vanilloid one (TRPV1) antagonists in acid-induced excitation of esophageal vagal afferent fibers of rats.

  Neuroscience 20090630

• Effect of increasing temperature on TRPV1-mediated responses in isolated rat pulmonary sensory neurons.

  American journal of physiology. Lung cellular and molecular physiology 20080301

• The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant.

  Molecular pain 20080101

• Three-dimensional quantitative structure-activity relationships and activity predictions of human TRPV1 channel antagonists: comparative molecular field analysis and comparative molecular similarity index analysis of cinnamides.

  Journal of medicinal chemistry 20071115

• Novel vanilloid receptor-1 antagonists: 1. Conformationally restricted analogues of trans-cinnamides.

  Journal of medicinal chemistry 20070726

• The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain.

  Journal of medicinal chemistry 20070531

• Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret.

  The European journal of neuroscience 20070501

• Antihyperalgesic effects of vanilloid-1 and bradykinin-1 receptor antagonists following spinal cord injury in rats.

  Journal of neurosurgery. Spine 20070501

• The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070328

• Thermal sensitivity of isolated vagal pulmonary sensory neurons: role of transient receptor potential vanilloid receptors.

  American journal of physiology. Regulatory, integrative and comparative physiology 20060901

• AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties.

  The Journal of pharmacology and experimental therapeutics 20050401

• Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides.

  Journal of medicinal chemistry 20050113

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• D-glucose-6-phosphate dehydrogenase (Entner-Doudoroff enzyme) from Pseudomonas fluorescens. Purification, properties and regulation.

  European journal of biochemistry 19751115