5469-70-5 | Pyridazin-3-amine

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$14.00	$10.00
10g	98%	in stock	$17.00	$12.00
25g	98%	in stock	$41.00	$29.00

Description

• Catalog Number: AB44430
• Chemical Name: Pyridazin-3-amine
• CAS Number: 5469-70-5
• Molecular Formula: C4H5N3
• Molecular Weight: 95.1026
• MDL Number: MFCD01529869
• SMILES: Nc1cccnn1
• NSC Number: 25228

Computed Properties

• Complexity: 54.9
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 7
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• XLogP3: -1.2

Upstream Synthesis Route

3-Aminopyridazine is a versatile chemical compound that finds extensive application in modern organic synthesis. This highly reactive compound serves as a key building block in the production of various pharmaceuticals, agrochemicals, and fine chemicals. Its unique structure and reactivity make it a valuable intermediate in the synthesis of complex molecules.One prominent application of 3-Aminopyridazine is its use as a starting material in the preparation of heterocyclic compounds. By undergoing various transformations, such as cyclization reactions and functional group modifications, 3-Aminopyridazine can be transformed into structurally diverse compounds with diverse biological activities.Furthermore, 3-Aminopyridazine has been utilized in the synthesis of molecular probes and fluorescent labels due to its ability to undergo reactions with various functional groups. Its versatility in chemical reactions allows for the introduction of specific properties or functionalities into target molecules, making it a valuable tool in chemical biology and medicinal chemistry research.In summary, 3-Aminopyridazine is a crucial reagent in chemical synthesis, enabling the creation of novel molecules with potential applications in pharmaceuticals, agrochemicals, and materials science. Its versatility and reactivity make it an essential component in the toolkit of synthetic chemists seeking to develop new compounds with tailored properties and functions.

Literature

• Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2.

  Journal of medicinal chemistry 20160526

• Competitive antagonism of insect GABA receptors by iminopyridazine derivatives of GABA.

  Bioorganic & medicinal chemistry 20121001

• In vivo evaluation of alpha7 nicotinic acetylcholine receptor agonists [11C]A-582941 and [11C]A-844606 in mice and conscious monkeys.

  PloS one 20100101

• Polyfunctional nitriles in organic syntheses: a novel route to aminopyrroles, pyridazines and pyrazolo[3,4-c]pyridazines.

  Molecules (Basel, Switzerland) 20090216

• A novel and convenient protocol for synthesis of pyridazines.

  Organic letters 20090115

• R75761, a lead compound for the development of antiviral drugs in late stage poliomyelitis eradication strategies and beyond.

  Antiviral research 20080601

• Privileged structures: a useful concept for the rational design of new lead drug candidates.

  Mini reviews in medicinal chemistry 20071101

• Use of 4-bromo pyridazine 3,6-dione for building 3-amino pyridazine libraries.

  Molecular diversity 20060801

• De novo and molecular target-independent discovery of orally bioavailable lead compounds for neurological disorders.

  Current Alzheimer research 20060701

• Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation.

  Journal of molecular neuroscience : MN 20040101

• Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo.

  Neurobiology of aging 20040101

• An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury.

  Bioorganic & medicinal chemistry letters 20031020

• Discovery of new chemical classes of synthetic ligands that suppress neuroinflammatory responses.

  Journal of molecular neuroscience : MN 20020101

• Serotonin receptor and transporter ligands - current status.

  Current medicinal chemistry 20010701

• Structure-based 3D QSAR and design of novel acetylcholinesterase inhibitors.

  Journal of computer-aided molecular design 20010501