548-83-4 | Galangin

Packsize	Purity	Availability	Price	Discounted Price
25mg	95%	in stock	$39.00	$27.00
100mg	95%	in stock	$110.00	$77.00
250mg	95%	in stock	$177.00	$124.00
1g	95%	in stock	$431.00	$302.00

Description

• Catalog Number: AI52293
• Chemical Name: Galangin
• CAS Number: 548-83-4
• Molecular Formula: C15H10O5
• Molecular Weight: 270.2369
• MDL Number: MFCD00006833
• SMILES: Oc1cc(O)c2c(c1)oc(c(c2=O)O)c1ccccc1
• NSC Number: 407229

Computed Properties

• Complexity: 424
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 1
• XLogP3: 2.3

Literature

• Galangin induces cell death by modulating the expression of glyoxalase-1 and Nrf-2 in HeLa cells.

  Chemico-biological interactions 20180105

• Comparative Developmental Toxicity of Flavonoids Using an Integrative Zebrafish System.

  Toxicological sciences : an official journal of the Society of Toxicology 20161101

• Galangin prevents aminoglycoside-induced ototoxicity by decreasing mitochondrial production of reactive oxygen species in mouse cochlear cultures.

  Toxicology letters 20160314

• 3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease.

  Pharmacological research 20151001

• Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR).

  Toxicology letters 20150304

• Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo.

  Chemico-biological interactions 20141205

• Galangin suppresses HepG2 cell proliferation by activating the TGF-β receptor/Smad pathway.

  Toxicology 20141204

• Design, synthesis and exploring the quantitative structure-activity relationship of some antioxidant flavonoid analogues.

  Bioorganic & medicinal chemistry letters 20141101

• Galangin attenuates mast cell-mediated allergic inflammation.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130701

• In vivo investigation on the potential of galangin, kaempferol and myricetin for protection of D-galactose-induced cognitive impairment.

  Food chemistry 20121215

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• Flavonoid aglycones can compete with Ochratoxin A for human serum albumin: a new possible mode of action.

  International journal of biological macromolecules 20121001

• Influence of dietary flavonoids on the glycation of plasma proteins.

  Molecular bioSystems 20120801

• The photodegradation of quercetin: relation to oxidation.

  Molecules (Basel, Switzerland) 20120726

• The bioflavonoid galangin suppresses the growth of ehrlich ascites carcinoma in Swiss Albino mice: a molecular insight.

  Applied biochemistry and biotechnology 20120701

• Anticomplement and antimicrobial activities of flavonoids from Entada phaseoloides.

  Natural product communications 20120701

• SERS spectroscopy of kaempferol and galangin under the interaction of human serum albumin with adsorbed silver nanoparticles.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120615

• Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13.

  Bioorganic & medicinal chemistry letters 20120615

• Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy.

  European journal of medicinal chemistry 20120601

• Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test.

  Molecules (Basel, Switzerland) 20120507

• Inhibitory activity of liposomal flavonoids during oxidative metabolism of human neutrophils upon stimulation with immune complexes and phorbol ester.

  Drug delivery 20120501

• Galangin induces apoptosis in gastric cancer cells via regulation of ubiquitin carboxy-terminal hydrolase isozyme L1 and glutathione S-transferase P.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301

• Small molecule inhibitors of the HPV16-E6 interaction with caspase 8.

  Bioorganic & medicinal chemistry letters 20120301

• Induction of oxidative DNA damage by flavonoids of propolis: its mechanism and implication about antioxidant capacity.

  Chemical research in toxicology 20120113

• Antimicrobial flavonoids from the twigs of Populus nigra x Populus deltoides.

  Natural product research 20120101

• ¹H-NMR simultaneous identification of health-relevant compounds in propolis extracts.

  Phytochemical analysis : PCA 20120101

• Synergistic activity and mode of action of flavonoids isolated from smaller galangal and amoxicillin combinations against amoxicillin-resistant Escherichia coli.

  Journal of applied microbiology 20120101

• New acetylcholinesterase inhibitors for Alzheimer's disease.

  International journal of Alzheimer's disease 20120101

• Molecular modeling study of chiral separation and recognition mechanism of β-adrenergic antagonists by capillary electrophoresis.

  International journal of molecular sciences 20120101

• De novo transcriptome of safflower and the identification of putative genes for oleosin and the biosynthesis of flavonoids.

  PloS one 20120101

• Propolis standardized extract (EPP-AF®), an innovative chemically and biologically reproducible pharmaceutical compound for treating wounds.

  International journal of biological sciences 20120101

• Galangin induces autophagy through upregulation of p53 in HepG2 cells.

  Pharmacology 20120101

• AHR and the Transcriptional Regulation of Type-17/22 ILC.

  Frontiers in immunology 20120101

• Galangin induces apoptosis in hepatocellular carcinoma cells through the caspase 8/t-Bid mitochondrial pathway.

  Journal of Asian natural products research 20120101

• Novel norcantharidin-loaded liver targeting chitosan nanoparticles to enhance intestinal absorption.

  International journal of nanomedicine 20120101

• Correlation between mammalian cell cytotoxicity of flavonoids and the redox potential of phenoxyl radical/phenol couple.

  Acta biochimica Polonica 20120101

• Trihydroxyflavones with antioxidant and anti-inflammatory efficacy.

  BioFactors (Oxford, England) 20120101

• Antioxidant capacity of flavonoids in hepatic microsomes is not reflected by antioxidant effects in vivo.

  Oxidative medicine and cellular longevity 20120101

• Influence of oxidative stress on inducing micturition dysfunction following chronic infravesical obstruction and the protective role of an antioxidant diet - association of in vivo and in vitro studies in rats.

  International braz j urol : official journal of the Brazilian Society of Urology 20120101

• Characterization of flavonol inhibition of DnaB helicase: real-time monitoring, structural modeling, and proposed mechanism.

  Journal of biomedicine & biotechnology 20120101

• Toxicological aspects of the use of phenolic compounds in disease prevention.

  Interdisciplinary toxicology 20111201

• Galanin and the orexin 2 receptor as possible regulators of enkephalin in the paraventricular nucleus of the hypothalamus: relation to dietary fat.

  Neuroscience 20111013

• Current pharmacological and phytochemical studies of the plant Alpinia galanga.

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20111001

• Effect of galangin supplementation on oxidative damage and inflammatory changes in fructose-fed rat liver.

  Chemico-biological interactions 20110905

• Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain.

  European journal of medicinal chemistry 20110901

• Analysis of flavonoids in honey by HPLC coupled with coulometric electrode array detection and electrospray ionization mass spectrometry.

  Analytical and bioanalytical chemistry 20110601

• Galangin suppresses the proliferation of β-catenin response transcription-positive cancer cells by promoting adenomatous polyposis coli/Axin/glycogen synthase kinase-3β-independent β-catenin degradation.

  Molecular pharmacology 20110601

• Chemical composition of the ethanolic propolis extracts and its effect on HeLa cells.

  Journal of ethnopharmacology 20110601

• Bioactivity guided isolation of anticancer constituents from leaves of Alnus sieboldiana (Betulaceae).

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20110415

• Effect of traditional Chinese medicinal herbs on Candida spp. from patients with HIV/AIDS.

  Advances in dental research 20110401

• Ethanolic Extract of Propolis Augments TRAIL-Induced Apoptotic Death in Prostate Cancer Cells.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Concentration-Dependent Protection by Ethanol Extract of Propolis against γ-Ray-Induced Chromosome Damage in Human Blood Lymphocytes.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Inhibition of Klebsiella pneumoniae DnaB helicase by the flavonol galangin.

  The protein journal 20110101

• In-vitro antiviral activity of Solanum nigrum against Hepatitis C Virus.

  Virology journal 20110101

• The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

  International journal of molecular sciences 20110101

• Honey induces apoptosis in renal cell carcinoma.

  Pharmacognosy magazine 20110101

• In vitro evaluation of the antioxidant activity of liposomal flavonols by the HRP-H2O2-luminol system.

  Journal of microencapsulation 20110101

• Clinical Evidence of the Efficacy of a Mouthwash Containing Propolis for the Control of Plaque and Gingivitis: A Phase II Study.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Analytical methods applied to diverse types of Brazilian propolis.

  Chemistry Central journal 20110101

• Polyphenolic fraction of Algerian propolis protects rat kidney against acute oxidative stress induced by doxorubicin.

  Indian journal of nephrology 20110101

• Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells.

  Neoplasma 20110101

• Honey and renal cell carcinoma.

  Pharmacognosy magazine 20110101

• [Composition, antifungal and radical scavenging activities of 4 propolis].

  Medical mycology journal 20110101

• Propolis can potentialise the anti-adhesion activity of proanthocyanidins on uropathogenic Escherichia coli in the prevention of recurrent urinary tract infections.

  BMC research notes 20110101

• Effect of Turkish propolis extracts on proteome of prostate cancer cell line.

  Proteome science 20110101

• Bioactive constituents and medicinal importance of genus Alnus.

  Pharmacognosy reviews 20110101

• Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives.

  Chemical research in toxicology 20101220

• Reversing β-lactam antibiotic resistance of Staphylococcus aureus with galangin from Alpinia officinarum Hance and synergism with ceftazidime.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20101215

• 3-O-arylmethylgalangin, a novel isostere for anti-HCV 1,3-diketoacids (DKAs).

  Bioorganic & medicinal chemistry 20101101

• 7-O-Arylmethylgalangin as a novel scaffold for anti-HCV agents.

  Bioorganic & medicinal chemistry letters 20101001

• Relationships between structures of hydroxyflavones and their antioxidative effects.

  Bioorganic & medicinal chemistry letters 20100915

• Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro.

  Chemico-biological interactions 20100906

• Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction.

  Archives of biochemistry and biophysics 20100901

• Selective inhibition of methoxyflavonoids on human CYP1B1 activity.

  Bioorganic & medicinal chemistry 20100901

• Semantic similarity for automatic classification of chemical compounds.

  PLoS computational biology 20100901

• Galangin induces apoptosis of hepatocellular carcinoma cells via the mitochondrial pathway.

  World journal of gastroenterology 20100721

• Metabolites of galangin by 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P450 1A1 in human intestinal epithelial Caco-2 cells and their antagonistic activity toward aryl hydrocarbon receptor.

  Journal of agricultural and food chemistry 20100714

• In vitro modulation of naturally occurring flavonoids on cytochrome P450 2A6 (CYP2A6) activity.

  Xenobiotica; the fate of foreign compounds in biological systems 20100701

• Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism.

  Biochemical pharmacology 20100601

• Dietary bioflavonoids inhibit Escherichia coli ATP synthase in a differential manner.

  International journal of biological macromolecules 20100601

• Generalized concentration addition predicts joint effects of aryl hydrocarbon receptor agonists with partial agonists and competitive antagonists.

  Environmental health perspectives 20100501

• Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells.

  Journal of natural products 20100423

• Biogenic synthesis of Au and Ag nanoparticles by Indian propolis and its constituents.

  Colloids and surfaces. B, Biointerfaces 20100301

• Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd.

  Indian journal of experimental biology 20100301

• Effect of Zinc (II) on the interactions of bovine serum albumin with flavonols bearing different number of hydroxyl substituent on B-ring.

  Journal of inorganic biochemistry 20100201

• Argentinean propolis from Zuccagnia punctata Cav. (Caesalpinieae) exudates: phytochemical characterization and antifungal activity.

  Journal of agricultural and food chemistry 20100113

• Antiviral activity and mode of action of propolis extracts and selected compounds.

  Phytotherapy research : PTR 20100101

• Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase.

  European journal of medicinal chemistry 20100101

• Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.

  Bioorganic & medicinal chemistry 20100101

• Apoptotic effects of chrysin in human cancer cell lines.

  International journal of molecular sciences 20100101

• A novel dietary supplement containing multiple phytochemicals and vitamins elevates hepatorenal and cardiac antioxidant enzymes in the absence of significant serum chemistry and genomic changes.

  Oxidative medicine and cellular longevity 20100101

• Differential mechanisms for the inhibition of human cytochrome P450 1A2 by apigenin and genistein.

  Journal of biochemical and molecular toxicology 20100101

• Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines.

  BMC complementary and alternative medicine 20100101

• Potent modification of inducible CYP1A1 expression by flavonoids.

  Biological & pharmaceutical bulletin 20100101

• Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro.

  International journal of biological sciences 20100101

• Dose-dependent effect of galangin on fructose-mediated insulin resistance and oxidative events in rat kidney.

  Redox report : communications in free radical research 20100101

• Novel screening method for potential skin-whitening compounds by a luciferase reporter assay.

  Bioscience, biotechnology, and biochemistry 20100101

• Genotoxicity and mutagenicity of Echinodorus macrophyllus (chapéu-de-couro) extracts.

  Genetics and molecular biology 20100101

• The potential role of honey and its polyphenols in preventing heart diseases: a review.

  African journal of traditional, complementary, and alternative medicines : AJTCAM 20100101

• Isolation of β-sitosterol diglucosyl caprate from Alpinia galanga.

  Pharmacognosy research 20100101

• Effect of seasonal variations and collection form on antioxidant activity of propolis from San Juan, Argentina.

  Journal of medicinal food 20091201

• Influence of the target molecule on the oxygen radical absorbance capacity index: a comparison between alizarin red- and fluorescein-based methodologies.

  Journal of medicinal food 20091201

• Methylation of dietary flavones increases their metabolic stability and chemopreventive effects.

  International journal of molecular sciences 20091101

• Two new sesquiterpene glucosides from Dennstaedtia scabra (Wall.) Moore.

  Chemical & pharmaceutical bulletin 20091001

• Antimicrobial activity of two propolis samples against human Campylobacter jejuni.

  Journal of medicinal food 20091001

• Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay.

  Bioorganic & medicinal chemistry letters 20090815

• Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells.

  Bioorganic & medicinal chemistry 20090815

• Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study.

  Chemical research in toxicology 20090701

• Simultaneous quantification of eight major bioactive phenolic compounds in Chinese propolis by high-performance liquid chromatography.

  Natural product communications 20090601

• Correlation between antiangiogenic activity and antioxidant activity of various components from propolis.

  Molecular nutrition & food research 20090501

• Main flavonoids, DPPH activity, and metal content allow determination of the geographical origin of propolis from the Province of San Juan (Argentina).

  Journal of agricultural and food chemistry 20090408

• Acidity of hydroxyl groups: an overlooked influence on antiradical properties of flavonoids.

  The Journal of organic chemistry 20090403

• Cytotoxic constituents of chinese propolis.

  Journal of natural products 20090401

• Comparison of intraperitoneal honey and sodium hyaluronate-carboxymethylcellulose (Seprafilm) for the prevention of postoperative intra-abdominal adhesions.

  Clinics (Sao Paulo, Brazil) 20090401

• Subcellular localization of flavonol aglycone in hepatocytes visualized by confocal laser scanning fluorescence microscope.

  Cytotechnology 20090401

• Mechanism of CYP2C9 inhibition by flavones and flavonols.

  Drug metabolism and disposition: the biological fate of chemicals 20090301

• Antioxidant effects of flavonoid from Croatian Cystus incanus L. rich bee pollen.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090301

• Flavonoid-induced morphological modifications of endothelial cells through microtubule stabilization.

  Nutrition and cancer 20090101

• Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention.

  BMC cancer 20090101

• Assessment of the medicinal potentials of the methanol extracts of the leaves and stems of Buddleja saligna.

  BMC complementary and alternative medicine 20090101

• From functional food to medicinal product: systematic approach in analysis of polyphenolics from propolis and wine.

  Nutrition journal 20090101

• Antiproliferative effects of honey and of its polyphenols: a review.

  Journal of biomedicine & biotechnology 20090101

• Yeast artificial chromosomes employed for random assembly of biosynthetic pathways and production of diverse compounds in Saccharomyces cerevisiae.

  Microbial cell factories 20090101

• Bioactivity of flavonoids isolated from Lychnophora markgravii against Leishmania amazonensis amastigotes.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

• Bee products prevent VEGF-induced angiogenesis in human umbilical vein endothelial cells.

  BMC complementary and alternative medicine 20090101

• [Comparative effects of flavonoids on cell cycle passage and apoptosis induction in human acute lymphoblastic leukemia MT-4 cells].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20090101

• Protective effects of Chinese propolis and its component, chrysin, against neuronal cell death via inhibition of mitochondrial apoptosis pathway in SH-SY5Y cells.

  Journal of agricultural and food chemistry 20081008

• Screening of herbal constituents for aromatase inhibitory activity.

  Bioorganic & medicinal chemistry 20080915

• Antioxidant activity of flavonoids in isolated mitochondria.

  Phytotherapy research : PTR 20080901

• Protective effects of epigallocatechin gallate after UV irradiation of cultured human lens epithelial cells.

  Korean journal of ophthalmology : KJO 20080901

• Chemical composition and botanical origin of red propolis, a new type of brazilian propolis.

  Evidence-based complementary and alternative medicine : eCAM 20080901

• Inhibition of peroxide-induced radical generation by plant polyphenols in C6 astroglioma cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20080801

• [Study on apoptosis of BEL-7402 cells induced by galangin].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080801

• Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells.

  Cancer letters 20080708

• Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria x ananassa) achene and receptacle.

  Journal of experimental botany 20080701

• Role of Bax in quercetin-induced apoptosis in human prostate cancer cells.

  Biochemical pharmacology 20080615

• Synergistic effects of the combination of galangin with gentamicin against methicillin-resistant Staphylococcus aureus.

  Journal of microbiology (Seoul, Korea) 20080601

• Polyphenol contents and antioxidant activities of five Indigofera species (Fabaceae) from Burkina Faso.

  Pakistan journal of biological sciences : PJBS 20080601

• Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron.

  Journal of cellular biochemistry 20080415

• Influence of B-ring hydroxylation on interactions of flavonols with bovine serum albumin.

  Journal of agricultural and food chemistry 20080409

• Complexation of flavonoids with iron: structure and optical signatures.

  The journal of physical chemistry. B 20080214

• Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism.

  Breast cancer research : BCR 20080101

• Antibacterial and antioxidant properties of the methanol extracts of the leaves and stems of Calpurnia aurea.

  BMC complementary and alternative medicine 20080101

• The flavonoid, fisetin, inhibits UV radiation-induced oxidative stress and the activation of NF-kappaB and MAPK signaling in human lens epithelial cells.

  Molecular vision 20080101

• Protective effects of epigallocatechin gallate after UV irradiation in cultured human retinal pigment epithelial cells.

  Korean journal of ophthalmology : KJO 20071201

• [Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60].

  Ai zheng = Aizheng = Chinese journal of cancer 20071201

• Analysis of the polyphenolic fraction of propolis from different sources by liquid chromatography-tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20071105

• Studies on the interactions between some flavonols and cyclodextrins.

  Bioorganic & medicinal chemistry letters 20071101

• Sonoran propolis: chemical composition and antiproliferative activity on cancer cell lines.

  Planta medica 20071101

• Aggregation of Staphylococcus aureus following treatment with the antibacterial flavonol galangin.

  Journal of applied microbiology 20071101

• Determination of flavonoid aglycones in several food samples by mixed micellar electrokinetic chromatography.

  Journal of separation science 20071001

• Effect of mouthrinse containing propolis on oral microorganisms and human gingival fibroblasts.

  European journal of dentistry 20071001

• Mechanism of inhibition of human secretory phospholipase A2 by flavonoids: rationale for lead design.

  Journal of computer-aided molecular design 20070801

• Mechanism and inhibitory effect of galangin and its flavonoid mixture from Alpinia officinarum on mushroom tyrosinase and B16 murine melanoma cells.

  Journal of enzyme inhibition and medicinal chemistry 20070801

• Neutrophil effector functions triggered by Fc-gamma and/or complement receptors are dependent on B-ring hydroxylation pattern and physicochemical properties of flavonols.

  Life sciences 20070704

• Esterase inhibition by grapefruit juice flavonoids leading to a new drug interaction.

  Drug metabolism and disposition: the biological fate of chemicals 20070701

• Evaluation of antioxidative activity of Croatian propolis samples using DPPH* and ABTS*+ stable free radical assays.

  Molecules (Basel, Switzerland) 20070515

• [Quantitative analysis of galangin from propolis in different areas by HPLC].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070501

• Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: a comparison of different flavonoids in activating estrogenic effect and in preventing beta-amyloid-induced cell death.

  Journal of agricultural and food chemistry 20070321

• Chemopreventive herbal anti-oxidants: current status and future perspectives.

  Journal of clinical biochemistry and nutrition 20070301

• Inhibition of horseradish peroxidase catalytic activity by new 3-phenylcoumarin derivatives: synthesis and structure-activity relationships.

  Bioorganic & medicinal chemistry 20070201

• In vitro antimicrobial activity of propolis samples from different geographical origins against certain oral pathogens.

  Anaerobe 20070101

• Optimisation of an extraction procedure and chemical characterisation of Croatian propolis tinctures.

  Phytochemical analysis : PCA 20070101

• Elastase release by stimulated neutrophils inhibited by flavonoids: importance of the catechol group.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101

• Different extraction methods of biologically active components from propolis: a preliminary study.

  Chemistry Central journal 20070101

• Evaluation of propolis polyphenols absorption in humans by liquid chromatography/tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20070101

• Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism.

  The Journal of biological chemistry 20061201

• TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers.

  Journal of agricultural and food chemistry 20061115

• Influence of galangin on HL-60 cell proliferation and survival.

  Cancer letters 20061108

• Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death.

  Investigative ophthalmology & visual science 20060701

• Propolis from the northwest of Argentina as a source of antifungal principles.

  Journal of applied microbiology 20060701

• Combinatorial biosynthesis of flavones and flavonols in Escherichia coli.

  Applied microbiology and biotechnology 20060601

• Antiparasitic activity of flavonoids and isoflavones against Cryptosporidium parvum and Encephalitozoon intestinalis.

  FEMS microbiology letters 20060601

• Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.

  Journal of medicinal chemistry 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Methylation protects dietary flavonoids from rapid hepatic metabolism.

  Xenobiotica; the fate of foreign compounds in biological systems 20060501

• Chemical structure of flavonols in relation to modulation of angiogenesis and immune-endothelial cell adhesion.

  The Journal of nutritional biochemistry 20060301

• Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.

  Toxicology in vitro : an international journal published in association with BIBRA 20060301

• Inhibition of rat vas deferens contractions by flavonoids in-vitro.

  The Journal of pharmacy and pharmacology 20060301

• Assessment of the antibacterial activity of galangin against 4-quinolone resistant strains of Staphylococcus aureus.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20060201

• Vasorelaxant effect of the flavonoid galangin on isolated rat thoracic aorta.

  Life sciences 20060118

• Inhibitors from the rhizomes of Alpinia officinarum on production of nitric oxide in lipopolysaccharide-activated macrophages and the structural requirements of diarylheptanoids for the activity.

  Bioorganic & medicinal chemistry 20060101

• Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds.

  Molecular nutrition & food research 20060101

• Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A.

  Breast cancer research : BCR 20060101

• Human cytomegalovirus-inhibitory flavonoids: studies on antiviral activity and mechanism of action.

  Antiviral research 20051201

• Galangin protects pig detrusor nerves from repetitive field stimulation and anoxia/glucopenia injury.

  Urology 20051201

• The effect of quercetin and galangin on glutathione reductase.

  Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201

• Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro.

  Archives of pharmacal research 20051101

• Molecular targets of dietary polyphenols with anti-inflammatory properties.

  Yonsei medical journal 20051031

• Detection of galangin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss.

  Journal of ethnopharmacology 20051003

• The inhibitory effect of the flavonoid galangin on urinary bladder smooth muscle contractility is mediated in part by modulation of Ca2+ release from intracellular stores.

  Planta medica 20051001

• Synthesis, spectral and electrochemical properties of Al(III) and Zn(II) complexes with flavonoids.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050701

• Flavonoid galangin prevents smooth muscle fatigue of pig urinary bladder.

  The Journal of pharmacy and pharmacology 20050501

• Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids.

  Archives of pharmacal research 20050501

• The interaction of flavonoids with mitochondria: effects on energetic processes.

  Chemico-biological interactions 20050415

• Flavonoids and tyrosine nitration: structure-activity relationship correlation with enthalpy of formation.

  Toxicology in vitro : an international journal published in association with BIBRA 20050301

• [Xanthine oxidase inhibitory activity and hypouricemia effect of propolis in rats].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20050301

• Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2.

  Biochemical pharmacology 20050215

• Chemical compositions and antimicrobial activities of four different Anatolian propolis samples.

  Microbiological research 20050101

• Multiple-signaling pathways are involved in the inhibitory effects of galangin on urinary bladder contractility.

  Neurourology and urodynamics 20050101

• Galangin expresses bactericidal activity against multiple-resistant bacteria: MRSA, Enterococcus spp. and Pseudomonas aeruginosa.

  FEMS microbiology letters 20041101

• Inhibitory effect of flavonoids on N-acetylation of 5-aminosalicylic acid in cultured rat hepatocytes.

  Biological & pharmaceutical bulletin 20040901

• Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription.

  Mutation research 20040713

• The thiol reactivity of the oxidation product of 3,5,7-trihydroxy-4H-chromen-4-one containing flavonoids.

  Toxicology letters 20040615

• Separation of flavonoids and phenolic acids from propolis by capillary zone electrophoresis.

  Electrophoresis 20040601

• Identification of metabolites in plasma and urine of Uruguayan propolis-treated rats.

  Journal of agricultural and food chemistry 20040519

• Inhibitory effect of flavonoids on sulfo- and glucurono-conjugation of acetaminophen in rat cultured hepatocytes and liver subcellular preparations.

  Biological & pharmaceutical bulletin 20040501

• Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells.

  Biochemical pharmacology 20040415

• Determination of flavonoids by high-performance liquid chromatography and capillary electrophoresis.

  Journal of chromatography. A 20040402

• Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.

  Biochemical and biophysical research communications 20040319

• Effects of ethanol extract of propolis (EEP) and its flavones on inducible gene expression in J774A.1 macrophages.

  Journal of ethnopharmacology 20040301

• Herbal modulation of P-glycoprotein.

  Drug metabolism reviews 20040201

• Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake.

  The Journal of biological chemistry 20040109

• Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action.

  Breast cancer research : BCR 20040101

• Antioxidant properties of complexes of flavonoids with metal ions.

  Redox report : communications in free radical research 20040101

• Validated methods for the quantification of biologically active constituents of poplar-type propolis.

  Phytochemical analysis : PCA 20040101

• Flavonoids induce apoptosis in human leukemia U937 cells through caspase- and caspase-calpain-dependent pathways.

  Nutrition and cancer 20040101

• Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.

  Environmental health perspectives 20031201

• Analysis of propolis from the continental and Adriatic regions of Croatia.

  Acta pharmaceutica (Zagreb, Croatia) 20031201

• Reduction of genistein clastogenicity in Chinese hamster V79 cells by daidzein and other flavonoids.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20031001

• Presence of fatty acid synthase inhibitors in the rhizome of Alpinia officinarum hance.

  Journal of enzyme inhibition and medicinal chemistry 20030801

• Anti-complement activity of constituents from the stem-bark of Juglans mandshurica.

  Biological & pharmaceutical bulletin 20030701

• Inhibitory effect of the plant flavonoid galangin on rat vas deferens in vitro.

  Life sciences 20030516

• Glucuronidation activity of the UGT2B17 enzyme toward xenobiotics.

  Drug metabolism and disposition: the biological fate of chemicals 20030501

• Taxonomic significance of flavonoid variation in temperate species of Nothofagus.

  Phytochemistry 20030401

• Inhibitory effects of some flavonoids on the activity of mushroom tyrosinase.

  Biochemistry. Biokhimiia 20030401

• Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy.

  Journal of agricultural and food chemistry 20030312

• Effect of flavone derivatives on interleukin-1beta (IL-1beta) mRNA expression and IL-1beta protein synthesis in stimulated RAW 264.7 macrophages.

  Scandinavian journal of immunology 20030201

• Effects of flavonoids on cisplatin-induced apoptosis of HL-60 and L1210 leukemia cells.

  Leukemia research 20030101

• Trypanocidal activity of Lychnophora staavioides Mart. (Vernonieae, Asteraceae).

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20030101

• Effects of flavonoids on glutathione and glutathione-related enzymes in cisplatin-treated L1210 leukemia cells.

  Neoplasma 20030101

• Assessment of the antibacterial activity of selected flavonoids and consideration of discrepancies between previous reports.

  Microbiological research 20030101

• Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.

  Journal of natural products 20021201

• Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin.

  Fitoterapia 20021101

• The role of the phenethyl ester of caffeic acid (CAPE) in the inhibition of rat lung cyclooxygenase activity by propolis.

  Fitoterapia 20021101

• Phytochemical compounds involved in the anti-inflammatory effect of propolis extract.

  Fitoterapia 20021101

• Antiemetic principles of Alpinia officinarum.

  Journal of natural products 20020901

• The inhibitory effect of propolis and caffeic acid phenethyl ester on cyclooxygenase activity in J774 macrophages.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20020901

• Effect of the flavonoid galangin on urinary bladder rat contractility in-vitro.

  The Journal of pharmacy and pharmacology 20020801

• 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta.

  Cancer research 20020701

• Glucuronidation versus oxidation of the flavonoid galangin by human liver microsomes and hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20020501

• Constituents of Chinese propolis and their antiproliferative activities.

  Journal of natural products 20020501

• Rutin-enhanced antibacterial activities of flavonoids against Bacillus cereus and Salmonella enteritidis.

  Bioscience, biotechnology, and biochemistry 20020501

• Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of alpha-glucosidase action.

  Bioscience, biotechnology, and biochemistry 20020301

• The flavonoid galangin inhibits the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia.

  FEMS microbiology letters 20020219

• Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9.

  Drug metabolism and disposition: the biological fate of chemicals 20020201

• Interactions of flavones and other phytochemicals with adenosine receptors.

  Advances in experimental medicine and biology 20020101

• Chemical composition of European propolis: expected and unexpected results.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101

• Evaluation of the clastogenic, DNA intercalative, and topoisomerase II-interactive properties of bioflavonoids in Chinese hamster V79 cells.

  Environmental and molecular mutagenesis 20020101

• Inhibitory effects of naturally occurring compounds on aflatoxin B(1) biotransformation.

  Journal of agricultural and food chemistry 20011101

• Peroxynitrite scavenging of flavonoids: structure activity relationship.

  Environmental toxicology and pharmacology 20010901

• Anti-genotoxicity of galangin as a cancer chemopreventive agent candidate.

  Mutation research 20010501

• Role of lipophilicity and hydrogen peroxide formation in the cytotoxicity of flavonols.

  Bioscience, biotechnology, and biochemistry 20010501

• Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups.

  Toxicology in vitro : an international journal published in association with BIBRA 20010201

• Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1.

  Life sciences 20010112

• B-ring substituted 5,7-dihydroxyflavonols with high-affinity binding to P-glycoprotein responsible for cell multidrug resistance.

  Bioorganic & medicinal chemistry letters 20010108

• Vancomycin resistance reversal in enterococci by flavonoids.

  The Journal of pharmacy and pharmacology 20010101

• The bioflavonoid galangin blocks aryl hydrocarbon receptor activation and polycyclic aromatic hydrocarbon-induced pre-B cell apoptosis.

  Molecular pharmacology 20000901

• Inhibitory activity of flavonoids and tannins against HIV-1 protease.

  Biological & pharmaceutical bulletin 20000901

• Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens.

  Journal of ethnopharmacology 19970401

• Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.

  Journal of medicinal chemistry 19960607

• Interactions of flavonoids and other phytochemicals with adenosine receptors.

  Journal of medicinal chemistry 19960202

• Inhibition of HIV activation in latently infected cells by flavonoid compounds.

  AIDS research and human retroviruses 19960101

• Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates.

  Drug metabolism and disposition: the biological fate of chemicals 19940101

• Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.

  Journal of natural products 19940101

• Flavones are inhibitors of HIV-1 proteinase.

  Biochemical and biophysical research communications 19921030

• Antimicrobial constituents of Gomphrena martiana and Gomphrena boliviana.

  Journal of ethnopharmacology 19920401

• Effects of propolis flavonoids on virus infectivity and replication.

  Microbiologica 19900701

• Inhibition of reverse transcriptases by flavonoids.

  Antiviral research 19890901

• Genetic effects of the flavonols quercetin, kaempferol, and galangin on Chinese hamster ovary cells in vitro.

  Mutation research 19830201

• [On the antimicrobial activity of propolis and propolis constituents (author's transl)].

  Die Pharmazie 19790101