55-22-1 | isonicotinic acid

Packsize	Purity	Availability	Price	Discounted Price
10g	98%	in stock	$6.00	$4.00
25g	98%	in stock	$8.00	$5.00
100g	98%	in stock	$9.00	$6.00
250g	98%	in stock	$19.00	$13.00
500g	98%	in stock	$30.00	$21.00

Description

• Catalog Number: AB46316
• Chemical Name: isonicotinic acid
• CAS Number: 55-22-1
• Molecular Formula: C6H5NO2
• Molecular Weight: 123.1094
• MDL Number: MFCD00006429
• SMILES: OC(=O)c1ccncc1
• NSC Number: 1483

Computed Properties

• Complexity: 108
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 0.4

Upstream Synthesis Route

Isonicotinic acid, also known as pyridine-4-carboxylic acid, is a versatile compound widely used in chemical synthesis. This organic acid plays a crucial role in the pharmaceutical industry, where it serves as a key building block for the synthesis of various drug molecules.One of the primary applications of isonicotinic acid in chemical synthesis is its use in the production of anti-tuberculosis drugs, such as isoniazid. By reacting isonicotinic acid with hydrazine, isoniazid is formed, which is a potent medication used in the treatment of tuberculosis. Isonicotinic acid's conjugate base, isonicotinate, is also utilized in the synthesis of other pharmaceutical compounds due to its ability to form stable complexes with metal ions.In addition to its pharmaceutical applications, isonicotinic acid is employed in the preparation of various metal complexes and coordination compounds. Its nitrogen-containing ring structure allows it to chelate with metal ions, forming stable coordination complexes that find utility in catalysis, materials science, and analytical chemistry.Furthermore, isonicotinic acid can be used as a precursor in the synthesis of heterocyclic compounds, such as pyridine derivatives and pharmaceutical intermediates. Its unique chemical properties make it a valuable building block in organic synthesis, enabling the creation of diverse molecular structures with specific properties and functionalities.Overall, isonicotinic acid's versatility and reactivity make it a valuable compound in chemical synthesis, particularly in the pharmaceutical industry, where it contributes to the development of life-saving medications and novel chemical entities.

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• catena-Poly[[[triaqua-(nitrato-κO,O')neodymium(III)]-bis-(μ(2)-pyridinium-4-carboxyl-ato-κO:O')] bis-(perchlorate) monohydrate].

  Acta crystallographica. Section E, Structure reports online 20090201

• Infrared and Raman study of some isonicotinic acid metal(II) halide and tetracyanonickelate complexes.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090101

• Induction of differentiation in k562 cell line by nicotinic acid-related compounds.

  Bioscience, biotechnology, and biochemistry 20090101

• Systemic acquired resistance in soybean is regulated by two proteins, Orthologous to Arabidopsis NPR1.

  BMC plant biology 20090101

• Poly[diaqua-μ(2)-isonicotinato-μ(2)-oxalato-terbium(III)].

  Acta crystallographica. Section E, Structure reports online 20090101

• Poly[diaqua-μ(2)-isonicotinato-μ(2)-oxalato-terbium(III)].

  Acta crystallographica. Section E, Structure reports online 20090101

• Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide.

  Journal of inorganic biochemistry 20081201

• catena-Poly[{di-μ-isonicotinato-bis[di-aqua-isonicotinatoeuropium(III)]}-μ-isonicotinato-[diisonicotinatocopper(II)]-μ-isonicotinato].

  Acta crystallographica. Section E, Structure reports online 20081201

• NMR and theoretical study on interactions between diperoxovanadate complex and 4-substituted pyridines.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081115

• The Arabidopsis GRAS protein SCL14 interacts with class II TGA transcription factors and is essential for the activation of stress-inducible promoters.

  The Plant cell 20081101

• Poly[(mu2-aqua-kappa2O:O)(mu3-azido-kappa3N1:N1:N3)(mu2-isonicotinato-kappa2O:O')lead(II)].

  Acta crystallographica. Section C, Crystal structure communications 20081101

• In vitro effects of molecular nanosomal hybrid compositions with oxidized dextrans, conjugated with isonicotinic acid hydrazine on peritoneal macrophages.

  Bulletin of experimental biology and medicine 20081101

• Synthesis, crystal structures, and luminescence of organic-lanthanide complexes with nicotinate and isonicotinate ligands.

  Inorganic chemistry 20081020

• Dimolybdenum bis-2,4,6-triisopropyl-benzoate bis-4-isonicotinate: a redox active analogue of 4,4'-bipyridine with ambivalent properties.

  Inorganic chemistry 20081020

• Dynamic crystal-to-crystal conversion of a 3D-3D coordination polymer by de- and re-hydration.

  Dalton transactions (Cambridge, England : 2003) 20081014

• Effects of anabolic and therapeutic doses of dexamethasone on thymus morphology and apoptosis in veal calves.

  The Veterinary record 20081011

• Sandwich-type tetranuclear lanthanide complexes with cucurbit[6]uril: from molecular compounds to coordination polymers.

  Inorganic chemistry 20081006

• [RuII(NO+)]3+-core complexes with 4-methyl-pyrimidine and ethyl-isonicotinate: synthesis, X-ray structure, spectroscopy, and computational and NO-release studies upon UVA irradiation.

  Journal of inorganic biochemistry 20081001

• Poly[tetra-aqua-μ(4)-bromido-di-μ(2)-bromido-μ(2)-hydroxido-di-μ(3)-iso-nicotinato-tetra-μ(2)-isonicotinato-tetra-copper(I)dithulium(III)].

  Acta crystallographica. Section E, Structure reports online 20081001

• N'-Prop-ylisonicotinohydrazide.

  Acta crystallographica. Section E, Structure reports online 20081001

• A highly sensitive spectrophotometric determination of micro amounts of vanadium(V) in environmental and alloy samples by using 3,4-dihydroxybenzaldehydeisonicotinoylhydrazone (3,4-DHBINH).

  Environmental monitoring and assessment 20080901

• Poly[[aqua-[μ(3)-(2,6-H(2))-isonicotinato-κN:O:O'][μ(2)-(2,6-H(2))-isonicotinato-κN:O]manganese(II)] ethanol solvate].

  Acta crystallographica. Section E, Structure reports online 20080801

• catena-Poly[[[diaqua-terbium(III)]-tri-μ(2)-isonicotinato-κO:O'] tris(perchlorate) monohydrate].

  Acta crystallographica. Section E, Structure reports online 20080801

• 1,3-Dicyclo-hexyl-1-isonicotinoylurea monohydrate.

  Acta crystallographica. Section E, Structure reports online 20080801

• 6-(4-Pyrid-yl)-3-(3,4,5-trimethoxy-phen-yl)-1,2,4-triazolo[3,4-b][1,3,4]thia-diazole.

  Acta crystallographica. Section E, Structure reports online 20080801

• Monolayers of the lipid derivatives of isoniazid at the air/water interface and the formation of self-assembled nanostructures in water.

  Colloids and surfaces. B, Biointerfaces 20080715

• 4-Carboxy-pyridinium 3-carb-oxy-4-hydroxy-benzene-sulfonate.

  Acta crystallographica. Section E, Structure reports online 20080701

• Regulation of cardiac sympathetic afferent reflex by GABA(A) and GABA(B) receptors in paraventricular nucleus in rats.

  The European journal of neuroscience 20080601

• A single-step sequencing method for the identification of Mycobacterium tuberculosis complex species.

  PLoS neglected tropical diseases 20080601

• catena-Poly[[bis-[(2-carboxy-benzoato-κO)silver(I)](Ag-Ag)]bis-(μ-isonicotinic acid-κN:O)].

  Acta crystallographica. Section E, Structure reports online 20080601

• Benzoyl-methyl pyridine-4-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20080601

• A unique 2D framework containing linear trimeric cobalt(II) of mixed Td-Oh-Td geometries linked by two different single-carboxylate-aromatic amine ligands: structure and magnetic properties.

  Dalton transactions (Cambridge, England : 2003) 20080514

• Effect of GABA A receptor activation on UT-coupled signaling pathways in rat cortical astrocytes.

  Peptides 20080501

• Evaluation of 2-methyl-3-hydroxy-4-pyridinecarboxylic acid as a possible chelating agent for iron and aluminium.

  Dalton transactions (Cambridge, England : 2003) 20080407

• Epimers of bicyclo[2.2.2]octan-2-ol derivatives with antiprotozoal activity.

  European journal of medicinal chemistry 20080401

• trans-Diaqua-bis(ethyl-enediamine-κN,N')copper(II) bis[3-(3-pyrid-yl)propionate] dihydrate.

  Acta crystallographica. Section E, Structure reports online 20080401

• Changes in the gene expression of C-myc and CD38 in HL-60 cells during differentiation induced by nicotinic acid-related compounds.

  Bioscience, biotechnology, and biochemistry 20080301

• Poly[diaqua-penta-kis(μ(4)-benzene-1,2-dicarboxyl-ato)(μ(3)-benzene-1,2-dicarboxyl-ato)tetra-thulium(III)].

  Acta crystallographica. Section E, Structure reports online 20080301

• NKCC1 cotransporter inactivation underlies embryonic development of chloride-mediated inhibition in mouse spinal motoneuron.

  The Journal of physiology 20080215

• trans-(1,8-Dibenzyl-1,3,6,8,10,13-hexa-azacyclo-tetra-deca-ne)diisonicotinatonickel(II).

  Acta crystallographica. Section E, Structure reports online 20080201

• Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: the methyl pyrazinylketone isonicotinoyl hydrazone series.

  Journal of medicinal chemistry 20080124

• Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives.

  Bioorganic & medicinal chemistry letters 20080115

• Linking two distinct layered networks of nanosized {Ln18} and {Cu24} wheels through isonicotinate ligands.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• Coordinated NH3-removal-induced hydrogen adsorption of Cu-complex crystals.

  Langmuir : the ACS journal of surfaces and colloids 20080101

• Determination of cortisol in human plasma by thin-layer chromatography and fluorescence derivatization with isonicotinic acid hydrazide.

  Journal of chromatographic science 20080101

• Facile, one-step production of niacin (vitamin B3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• Epithelial expression of mRNA and protein for IL-6, IL-10 and TNF-alpha in endobronchial biopsies in horses with recurrent airway obstruction.

  BMC veterinary research 20080101

• 'Diversity oriented synthesis' of functionalized chiral tetrahydropyridines: potential GABA receptor agonists and azasugars from natural amino acids via a sequential Baylis-Hillman reaction and RCM protocol.

  Journal of combinatorial chemistry 20080101

• Expression of gamma-aminobutyric acid receptor (subtype A) in prostate cancer.

  Acta oncologica (Stockholm, Sweden) 20080101

• Synthesis, structural, and biological studies of some schiff bases and their metal complexes.

  Metal-based drugs 20080101

• catena-Poly[[[tetra-aqua-samarium(III)]-di-μ-isonicotinato-κO:O'] chloride].

  Acta crystallographica. Section E, Structure reports online 20080101

• Sodium (1R,2S,5S)-2-hydr-oxy-6,6-dimethyl-bicyclo-[3.1.1]heptane-2-carboxyl-ate penta-hydrate.

  Acta crystallographica. Section E, Structure reports online 20080101

• 4-[4-(4-Fluoro-phen-yl)-2-methyl-5-oxo-2,5-dihydro-isoxazol-3-yl]-1-methyl-pyridinium iodide-4-[3-(4-fluoro-phen-yl)-2-methyl-5-oxo-2,5-dihydro-isoxazol-4-yl]-1-methyl-pyridinium iodide (0.6/0.4).

  Acta crystallographica. Section E, Structure reports online 20080101

• A review on plant-derived natural products and their analogs with anti-tumor activity.

  Indian journal of pharmacology 20080101

• {Ln(III)[mu(5)-kappa(2),kappa(1),kappa(1),kappa(1),kappa(1)-1,2-(CO2)(2)C6H4][isonicotine][H2O]}(2)Cu(I) x X (Ln = Eu, Sm, Nd; X = ClO4-, Cl-): a new pillared-layer approach to heterobimetallic 3d-4f 3d-network solids.

  Inorganic chemistry 20071210

• Isoniazid: metabolic aspects and toxicological correlates.

  Current drug metabolism 20071201

• Study on complex formation of biologically active pyridine derivatives with cyclodextrins by capillary electrophoresis.

  Journal of pharmaceutical and biomedical analysis 20071130

• A series of lanthanide-transition metal frameworks based on 1-, 2-, and 3D metal-organic motifs linked by different 1D copper(I) halide motifs.

  Inorganic chemistry 20071126

• Synthesis of (aryloxyacetylamino)-isonicotinic/nicotinic acid analogues as potent hypoxia-inducible factor (HIF)-1alpha inhibitors.

  Bioorganic & medicinal chemistry letters 20071115

• Differential baroreflex control of sympathetic drive by angiotensin II in the nucleus tractus solitarii.

  American journal of physiology. Regulatory, integrative and comparative physiology 20071101

• Salicylic acid is important for basal defense of Solanum tuberosum against Phytophthora infestans.

  Molecular plant-microbe interactions : MPMI 20071101

• Poly[aqua(mu3-benzene-1,2-dicarboxylato)bis(mu3-hydroxido)bis(mu2-isonicotinato)dierbium(III) monohydrate] and the thulium analogue.

  Acta crystallographica. Section C, Crystal structure communications 20071101

• Antimalarial cation-dimers synthesized in two steps from an inexpensive starting material, isonicotinic acid.

  ChemMedChem 20071001

• Amine modification of digested peptide at C-terminal end during protein digestion by protease.

  Biological & pharmaceutical bulletin 20071001

• Diversity of crystal structure with different lanthanide ions involving in situ oxidation-hydrolysis reaction.

  Dalton transactions (Cambridge, England : 2003) 20070928

• 3D homometallic carboxylate ferrimagnet constructed from a manganese(II) succinate carboxylate layer motif pillared by isonicotinate spacers.

  Inorganic chemistry 20070903

• Endogenous GABA and glutamate finely tune the bursting of olfactory bulb external tufted cells.

  Journal of neurophysiology 20070801

• Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid.

  Journal of medicinal chemistry 20070726

• 3D coordination framework [Ln(4)(mu(3)-OH)(2)Cu(6)I(5)(IN)(8)(OAc)(3)] (IN = isonicotinate): employing 2D layers of lanthanide wheel clusters and 1D chains of copper halide clusters.

  Inorganic chemistry 20070625

• A deliberate approach for the syntheses of heterometallic supramolecules containing dimolybdenum Mo(2)4+ species coordinated to other metal units.

  Dalton transactions (Cambridge, England : 2003) 20070614

• Surface modification of high-nuclearity lanthanide clusters: two tetramers constructed by cage-shaped [Dy26] clusters and isonicotinate linkers.

  Inorganic chemistry 20070416

• On the relevance of an antiferromagnetic dimer model for the spin-gapped magnetic solids Cu(terpy)Mo2O7 and Cu(OH)(p-pyc)H2O.

  Inorganic chemistry 20070402

• Identification of a cytochrome P450 cDNA (CYP98A5) from Phaseolus vulgaris, inducible by 3,5-dichlorosalicylic acid and 2,6-dichloro isonicotinic acid.

  Journal of plant physiology 20070401

• A regenerable ruthenium tetraammine nitrosyl complex immobilized on a modified silica gel surface: preparation and studies of nitric oxide release and nitrite-to-NO conversion.

  Journal of colloid and interface science 20070315

• LC and LC-MS study of stress decomposition behaviour of isoniazid and establishment of validated stability-indicating assay method.

  Journal of pharmaceutical and biomedical analysis 20070312

• Metallacrown-based compartments: selective encapsulation of three isonicotinate anions in non-centrosymmetric solids.

  Chemical communications (Cambridge, England) 20070312

• 4-Cyanobenzaldehyde isonicotinoylhydrazone monohydrate: a three-dimensional hydrogen-bonded framework structure.

  Acta crystallographica. Section C, Crystal structure communications 20070301

• Chemically induced expression of rice OSB2 under the control of the OsPR1.1 promoter confers increased anthocyanin accumulation in transgenic rice.

  Journal of agricultural and food chemistry 20070221

• First direct-formation and properties of microspherical superstructure. Morphology of diamineplatinum(II) complexes with isonicotinate.

  Chemical communications (Cambridge, England) 20070207

• Modulation of creatine kinase activity by ruthenium complexes.

  Journal of inorganic biochemistry 20070201

• 3-Nitrobenzaldehyde isonicotinoylhydrazone monohydrate redetermined at 120 K: sheets built from O-H...O, O-H...N, N-H...O and C-H...O hydrogen bonds.

  Acta crystallographica. Section C, Crystal structure communications 20070101

• Timing of the developmental switch in GABA(A) mediated signaling from excitation to inhibition in CA3 rat hippocampus using gramicidin perforated patch and extracellular recordings.

  Epilepsia 20070101

• [Relationship of the course of nephrotuberculosis in patients to various combinations of genetic markers].

  Problemy tuberkuleza i boleznei legkikh 20070101

• Regulation of betaine synthesis by precursor supply and choline monooxygenase expression in Amaranthus tricolor.

  Journal of experimental botany 20070101

• Photosensitizers containing the 1,8-naphthyridyl moiety and their use in dye-sensitized solar cells.

  Inorganic chemistry 20061211

• Langerhans cells release prostaglandin D2 in response to nicotinic acid.

  The Journal of investigative dermatology 20061201

• A robust microporous 3D cobalt(II) coordination polymer with new magnetically frustrated 2D lattices: single-crystal transformation and guest modulation of cooperative magnetic properties.

  Dalton transactions (Cambridge, England : 2003) 20061128

• Coordination framework hosts consisting of 4-pyridyl-substituted carboxylic acid (PCA) dimers and 1D chains of Ni2+ and SCN-: a rational structural extension toward coordination framework hosts with large rectangular cavities.

  Inorganic chemistry 20061113

• Spontaneously resolved homochiral 3D lanthanide-silver heterometallic coordination framework with extended helical Ln-O-Ag subunits.

  Inorganic chemistry 20061113

• Comparison of the anti-neoplastic effects of dirhodium(II) tetrapropionate and its adducts with nicotinate and isonicotinate anions in mice bearing Ehrlich tumors.

  European journal of medicinal chemistry 20061001

• A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation.

  Journal of the American Chemical Society 20060927

• The role of serendipity in drug discovery.

  Dialogues in clinical neuroscience 20060901

• The Kölliker-Fuse nucleus gates the postinspiratory phase of the respiratory cycle to control inspiratory off-switch and upper airway resistance in rat.

  The European journal of neuroscience 20060801

• Accurate length control of supramolecular oligomerization: Vernier assemblies.

  Journal of the American Chemical Society 20060712

• Subthalamic stimulation evokes complex EPSCs in the rat substantia nigra pars reticulata in vitro.

  The Journal of physiology 20060615

• Novel synthetic 2,6-dichloroisonicotinate derivatives as effective elicitors for inducing the biosynthesis of plant secondary metabolites.

  Applied microbiology and biotechnology 20060601

• GABA-induced calcium signaling in cultured enteric neurons is reinforced by activation of cholinergic pathways.

  Neuroscience 20060512

• Bioactive 1,4-dihydroisonicotinic acid derivatives prevent oxidative damage of liver cells.

  European journal of pharmacology 20060510

• Catalase-peroxidase of Mycobacterium bovis BCG converts isoniazid to isonicotinamide, but not to isonicotinic acid: differentiation parameter between enzymes of Mycobacterium bovis BCG and Mycobacterium tuberculosis.

  Biochimica et biophysica acta 20060501

• Separation of nicotinic acid and its structural isomers using 1-ethyl-3-methylimidazolium ionic liquid as a buffer additive by capillary electrophoresis.

  Journal of pharmaceutical and biomedical analysis 20060411

• First metal azide complex with isonicotinate as a bridging ligand showing new net topology: hydrothermal synthesis, structure, and magnetic properties.

  Inorganic chemistry 20060403

• IR-SERS study and theoretical analogue on the adsorption behavior of pyridine carboxylic acid on silver nanoparticles.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060301

• A simple synthetic route to methyl 3-fluoropyridine-4-carboxylate by nucleophilic aromatic substitution.

  Molecules (Basel, Switzerland) 20060225

• Monitoring the ingestion of anti-tuberculosis drugs by simple non-invasive methods.

  International journal of pharmaceutics 20060113

• Aerobic biodegradation of 4-methylpyridine and 4-ethylpyridine by newly isolated Pseudonocardia sp. strain M43.

  FEMS microbiology letters 20060101

• A rash imposition from a lifestyle omission: a case report of pellagra.

  The Ulster medical journal 20060101

• Acetylation genotype and phenotype in patients with systemic lupus erythematosus.

  Pharmacological reports : PR 20060101

• Effect of beclomethasone dipropionate and dexamethasone isonicotinate on lung function, bronchoalveolar lavage fluid cytology, and transcription factor expression in airways of horses with recurrent airway obstruction.

  Journal of veterinary internal medicine 20060101

• Isoniazid is not a lead compound for its pyridyl ring derivatives, isonicotinoyl amides, hydrazides, and hydrazones: a critical review.

  Current medicinal chemistry 20060101

• Synthesis, Biological, Spectral, and Thermal Investigations of Cobalt(II) and Nickel(II) Complexes of N-Isonicotinamido -2',4'-Dichlorobenzalaldimine.

  Bioinorganic chemistry and applications 20060101

• An investigation of the surface-enhanced Raman scattering (SERS) effect from a new substrate of silver-modified silver electrode.

  Journal of colloid and interface science 20051215

• Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci.

  Journal of medicinal chemistry 20051006

• Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro.

  Journal of neurophysiology 20051001

• pi-Stacked hydrogen-bonded chains of rings in 2,4-difluorobenzaldehyde isonicotinoylhydrazone and hydrogen-bonded sheets in 2,3-dichlorobenzaldehyde isonicotinoylhydrazone.

  Acta crystallographica. Section C, Crystal structure communications 20051001

• Open metal-organic framework containing cuprate chains.

  Inorganic chemistry 20050905

• A solvothermally in situ generated mixed-ligand approach for NLO-active metal-organic framework materials.

  Inorganic chemistry 20050613

• The relationship between chemical structure and antimicrobial activity of selected nicotinates, p-iodobenzoates, picolinates and isonicotinates.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050601

• Centrally-mediated antinociceptive actions of GABA(A) receptor agonists in the rat spared nerve injury model of neuropathic pain.

  European journal of pharmacology 20050601

• Surface-enhanced Raman spectroscopy using silver-coated porous glass-ceramic substrates.

  Applied spectroscopy 20050601

• Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family.

  The Biochemical journal 20050515

• Synthesis and characterization of hydrogen-bonded assemblies of W6S8L6 clusters.

  Inorganic chemistry 20050404

• Synthesis of isonicotinic acid N'-arylidene-N-[2-oxo-2-(4-aryl-piperazin-1-yl)-ethyl]-hydrazides as antituberculosis agents.

  Bioorganic & medicinal chemistry letters 20050315

• Respiratory rhythm entrainment by somatic afferent stimulation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050223

• Ditopic redox-active polyferrocenyl zinc(II) dithiocarbamate macrocyclic receptors: synthesis, coordination and electrochemical recognition properties.

  Dalton transactions (Cambridge, England : 2003) 20050221

• A 3D coordination framework based on linkages of nanosized hydroxo lanthanide clusters and copper centers by isonicotinate ligands.

  Angewandte Chemie (International ed. in English) 20050218

• Neurokininergic mechanism within the lateral crescent nucleus of the parabrachial complex participates in the heart-rate response to nociception.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050209

• A new layered zinc phosphate templated by protonated isonicotinate, [Zn2(C6H5NO2)2(HPO4)2].

  Acta crystallographica. Section C, Crystal structure communications 20050201

• Dinuclear zinc(II) dithiocarbamate macrocycles: ditopic receptors for a variety of guest molecules.

  Dalton transactions (Cambridge, England : 2003) 20050121

• Siloxane-supported organometallic compounds and their catalytic activities for the hydrosilylation of vinylsilanes and dienes.

  Dalton transactions (Cambridge, England : 2003) 20050107

• [Effects of a single dose of dexamethasone-21-isonicotinate on the phagocytosis performance of neutrophilic granulocytes and monocytes in periparturient dairy cows].

  Berliner und Munchener tierarztliche Wochenschrift 20050101

• Clinical presentation of abdominal tuberculosis in HIV seronegative adults.

  BMC gastroenterology 20050101

• Determination of ethylene thiourea in urine by HPLC-DAD.

  Journal of analytical toxicology 20050101

• Antioxidant activity of new ruthenium compounds.

  Redox report : communications in free radical research 20050101

• Insights into GABA receptor signalling in TM3 Leydig cells.

  Neuroendocrinology 20050101

• [DNA-repair modulation using derivatives of 1,4-dihydroisonicotinic acid as an example].

  TSitologiia i genetika 20050101

• Crystalline inclusion compounds constructed through self-assembly of isonicotinic acid and thiocyanato coordination bridges.

  Journal of the American Chemical Society 20041222

• Electrophysiological and neurochemical characterization of neurons of the medial preoptic area in Japanese quail (Coturnix japonica).

  Brain research 20041217

• Nonpolymeric hydrogelator derived from N-(4-pyridyl)isonicotinamide.

  Langmuir : the ACS journal of surfaces and colloids 20041123

• Molecular ordering in isonicotinic acid on rutile TiO2(110) investigated with valence band photoemission.

  The Journal of chemical physics 20041122

• Interference of isonicotinyl hydrazone in the microbiological analysis of rifampicin from anti-tuberculosis FDC products containing isoniazid.

  Journal of pharmaceutical and biomedical analysis 20041115

• Interparticle spacing control in the superlattices of carboxylic acid-capped gold nanoparticles by hydrogen-bonding mediation.

  Langmuir : the ACS journal of surfaces and colloids 20041109

• Antimycobacterial constituents from Juniperus procera, Ferula communis and Plumbago zeylanica and their in vitro synergistic activity with isonicotinic acid hydrazide.

  Phytotherapy research : PTR 20041101

• Effects of a single dose of dexamethasone-21-isonicotinate on the metabolism of heifers in early lactation.

  The Veterinary record 20041023

• Catalase-peroxidases (KatG) exhibit NADH oxidase activity.

  The Journal of biological chemistry 20041008

• Calcium-independent inhibition of GABA(A) current by caffeine in hippocampal slices.

  Brain research 20040806

• Nikkomycin biosynthesis: formation of a 4-electron oxidation product during turnover of NikD with its physiological substrate.

  Biochemistry 20040720

• Synthesis, absolute stereochemistry and molecular design of the new antifungal and antibacterial antibiotic produced by Streptomyces sp.201.

  Bioorganic & medicinal chemistry letters 20040705

• Guest sorption and desorption in the metal-organic framework [Co(INA)(2)] (INA=isonicotinate)--evidence of intermediate phases during desorption.

  Dalton transactions (Cambridge, England : 2003) 20040621

• 2-[(18)F]-fluoroisonicotinic acid hydrazide: biological evaluation in an acute infection model.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20040601

• A novel ligand-unsupported 3D framework polymer of trimeric copper(I) and its NLO property.

  Chemical communications (Cambridge, England) 20040507

• Usefulness of graphical invariants in quantitative structure-activity correlations of tuberculostatic drugs of the isonicotinic acid hydrazide type.

  Journal of molecular modeling 20040401

• Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus.

  The European journal of neuroscience 20040201

• A modeling study suggests complementary roles for GABAA and NMDA receptors and the SK channel in regulating the firing pattern in midbrain dopamine neurons.

  Journal of neurophysiology 20040101

• Isonicotinic acid hydrazide: an anti-tuberculosis drug inhibits malarial transmission in the mosquito gut.

  Experimental parasitology 20040101

• Stimulation of TM3 Leydig cell proliferation via GABA(A) receptors: a new role for testicular GABA.

  Reproductive biology and endocrinology : RB&E 20040101

• The effects of a single injection of dexamethasone-21-isonicotinate on the lymphocyte functions of dairy cows at two weeks post partum.

  Veterinary research 20040101

• [Experience with fenazid in perperas with respiratory tuberculosis and post-tuberculous changes in the lung].

  Problemy tuberkuleza i boleznei legkikh 20040101

• [Comparative assessment of cell mechanisms of the antidiabetic action of a new organic derivative of oxovanadium(IV) and vanadyl sulfate].

  Eksperimental'naia i klinicheskaia farmakologiia 20040101

• Electrochemical behavior of the antituberculosis drug isoniazid and its square-wave adsorptive stripping voltammetric estimation in bulk form, tablets and biological fluids at a mercury electrode.

  Journal of pharmaceutical and biomedical analysis 20031124

• A novel three-dimensional network constructed from tetramolybdate clusters linked via two types of copper complex fragments: synthesis, characterization, and magnetic behavior of [[CuII(2,2'-bpy)][CuII(IN)2][Mo4O12(OH)2]].

  Inorganic chemistry 20031103

• Unusual coordination assemblies from platinum(II) thienyl and bithienyl complexes.

  Inorganic chemistry 20031103

• Knockout analysis of Arabidopsis transcription factors TGA2, TGA5, and TGA6 reveals their redundant and essential roles in systemic acquired resistance.

  The Plant cell 20031101

• Synthesis, antitubercular activity and pharmacokinetic studies of some Schiff bases derived from 1-alkylisatin and isonicotinic acid hydrazide (INH).

  Archives of pharmacal research 20031001

• Differential arithmetic of shunting inhibition for voltage and spike rate in neocortical pyramidal cells.

  The European journal of neuroscience 20031001

• Nociception attenuates parasympathetic but not sympathetic baroreflex via NK1 receptors in the rat nucleus tractus solitarii.

  The Journal of physiology 20030901

• 3'-Azido-3'-deoxy-5'-O-isonicotinoylthymidine: a novel antiretroviral analog of zidovudine. II. Stability in aqueous media and experimental and theoretical ionization constants.

  Nucleosides, nucleotides & nucleic acids 20030901

• Expression of CD38 in human promyelocytic leukemia HL-60 cell line during differentiation by niacin-related compounds.

  Bioscience, biotechnology, and biochemistry 20030801

• Electrochromic devices based on binuclear mixed valence compounds adsorbed on nanocrystalline semiconductors.

  Inorganic chemistry 20030630

• N-isonicotinoyl-(L)-4-aminophenylalanine derivatives as tight binding VLA-4 antagonists.

  Bioorganic & medicinal chemistry letters 20030602

• Reactivity of tracheal smooth muscles in albino rats with experimental diabetes mellitus treated with a new complex compound of oxovanadium (IV) and isonicotinic acid hydrazide.

  Bulletin of experimental biology and medicine 20030601

• Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compounds.

  Bioscience, biotechnology, and biochemistry 20030501

• Reduced affinity for Isoniazid in the S315T mutant of Mycobacterium tuberculosis KatG is a key factor in antibiotic resistance.

  The Journal of biological chemistry 20030425

• A new type of three-dimensional framework constructed from dodecanuclear cadmium(II) macrocycles.

  Chemical communications (Cambridge, England) 20030421

• Cationic sigma-phenylplatinum(II) complexes with carboxylic acid functionality: pK(a) determinations and x-ray structures.

  Inorganic chemistry 20030224

• New heterometallic coordination polymers self-assembled from copper(II) nitrate and (diamine)Pt(II)(pyridinecarboxylates)(2).

  Inorganic chemistry 20030210

• A novel three-dimensional coordination polymer constructed with mixed-valence dimeric copper(I,II) units.

  Chemical communications (Cambridge, England) 20030207

• Modulation of CYP79 genes and glucosinolate profiles in Arabidopsis by defense signaling pathways.

  Plant physiology 20030101

• Systemic acquired resistance in sunflower (Helianthus annuus L.).

  TSitologiia i genetika 20030101

• Electrospray ionization mass spectrometry in studies of aluminium(III)-ligand solution equilibria.

  Rapid communications in mass spectrometry : RCM 20030101

• [Acute poisoning with selected hepatotoxic agents: biochemistry of toxic effect, clinical symptoms and treatment].

  Przeglad lekarski 20030101

• Modulation of the components of the rat dark-adapted electroretinogram by the three subtypes of GABA receptors.

  Visual neuroscience 20030101

• Utilization of glycine and serine as nitrogen sources in the roots of Zea mays and Chamaegigas intrepidus.

  Journal of experimental botany 20021201

• Pemphigus foliaceus in a goat.

  Veterinary dermatology 20021201

• gamma-Aminobutyric acid (A) receptor agonists accelerate cutaneous barrier recovery and prevent epidermal hyperplasia induced by barrier disruption.

  The Journal of investigative dermatology 20021101

• Novel synthesis of 2-[18F]-fluoroisonicotinic acid hydrazide and initial biological evaluation.

  Nuclear medicine and biology 20021101

• Heterobinuclear complexes as building blocks in designing extended structures.

  Inorganic chemistry 20021021

• Design and structural extension of a supramolecular inclusion-compound host made by the formation of dimers of isonicotinic acid and thiocyanato coordinating bridges.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20021018

• OsBIMK1, a rice MAP kinase gene involved in disease resistance responses.

  Planta 20021001

• Over-expression of TGA5, which encodes a bZIP transcription factor that interacts with NIM1/NPR1, confers SAR-independent resistance in Arabidopsis thaliana to Peronospora parasitica.

  The Plant journal : for cell and molecular biology 20021001

• The topochemical 1,6-polymerization of a triene.

  Journal of the American Chemical Society 20020911

• Furosemide modulation of GABA(A) receptors in dopaminergic neurones of the rat substantia nigra.

  Neuropharmacology 20020901

• Gramicidin S: a peptide model for protein glycation and reversal of glycation using nucleophilic amines.

  The journal of peptide research : official journal of the American Peptide Society 20020801

• GABA(A) receptor ligands and their therapeutic potentials.

  Current topics in medicinal chemistry 20020801

• Arabidopsis SON1 is an F-box protein that regulates a novel induced defense response independent of both salicylic acid and systemic acquired resistance.

  The Plant cell 20020701

• Chloroisonicotinamide derivative induces a broad range of disease resistance in rice and tobacco.

  Plant & cell physiology 20020701

• Synthesis of pyridine nucleotide analogs consisting of nicotinoylamino acids by means of transglycosidation reactions catalyzed by mammalian pyridine nucleotide transglycosidases.

  Journal of nutritional science and vitaminology 20020601

• [Electrochemical behavior of dopamine at the poly (isonicotinic acid) modified glassy carbon electrode].

  Yao xue xue bao = Acta pharmaceutica Sinica 20020601

• Priming in plant-pathogen interactions.

  Trends in plant science 20020501

• Pathogen stress increases somatic recombination frequency in Arabidopsis.

  Nature genetics 20020301

• Interpenetrating nets in cis-bis(pyridine-4-carboxylate)nickel(II).

  Acta crystallographica. Section C, Crystal structure communications 20020301

• Potential of a novel antibiotic, 2-methylheptyl isonicotinate, as a biocontrol agent against fusarial wilt of crucifers.

  Pest management science 20020301

• Radical scavenging activities of niacin-related compounds.

  Bioscience, biotechnology, and biochemistry 20020301

• Kinetics and mechanism of ligand interchange in pentacyano-L-osmate(II) complexes (L = H(2)O, NH(3), N-heterocyclic ligands).

  Inorganic chemistry 20020114

• Efficacy of three corticosteroids for the treatment of heaves.

  Equine veterinary journal 20020101

• Effects of coligand variation on the in vivo characteristics of Tc-99m-labeled interleukin-8 in detection of infection.

  Bioconjugate chemistry 20020101

• The molybdenum-containing hydroxylases of nicotinate, isonicotinate, and nicotine.

  Metal ions in biological systems 20020101

• Isonicotinic acid hydrazide induced anagen effluvium and associated lichenoid eruption.

  The Journal of dermatology 20011201

• Complex regional pain syndrome.

  Lancet (London, England) 20011103

• Salicylic acid and NIM1/NPR1-independent gene induction by incompatible Peronospora parasitica in arabidopsis.

  Molecular plant-microbe interactions : MPMI 20011001

• Potentiation of GABA(A) receptor agonists by GABA uptake inhibitors in the rat ventral midbrain.

  European journal of pharmacology 20010928

• Anticlastogenicity of two derivatives of 1,4-dihydroisonicotinic acid in mouse micronucleus test.

  Mutation research 20010920

• Complexes trans-[RuCl(2)(nic)(4)] and trans-[RuCl(2)(i-nic)(4)] as free radical scavengers.

  Journal of inorganic biochemistry 20010901

• Identification of catalase-like activity from Mycobacterium leprae and the relationship between catalase and isonicotinic acid hydrazide (INH).

  Journal of medical microbiology 20010801

• Direct visualization of protein interactions in plant cells.

  Nature biotechnology 20010801

• Identification of a 2,6-dichloroisonicotinic-acid-sensitive protein kinase from tobacco by affinity chromatography on benzothiadiazole-sepharose and NIM-metal chelate adsorbent.

  Pest management science 20010801

• [Method-performance studies of notified analytical method for inabenfide].

  Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20010801

• Anticonvulsant properties of the methanolic extract of Cyperus articulatus (Cyperaceae).

  Journal of ethnopharmacology 20010701

• Intravenous pyridoxine-induced metabolic acidosis.

  Annals of emergency medicine 20010701

• Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions.

  British journal of pharmacology 20010601

• Rh(III) porphyrins as building blocks for porphyrin coordination arrays: from dimers to heterometallic undecamers.

  Inorganic chemistry 20010521

• Post-episode depression of GABAergic transmission in spinal neurons of the chick embryo.

  Journal of neurophysiology 20010501

• GABAA receptor subunit interactions important for benzodiazepine and zinc modulation: a patch-clamp and single cell RT-PCR study.

  The European journal of neuroscience 20010501

• Ion interaction reagent reversed-phase high-performance liquid chromatography determination of anti-tuberculosis drugs and metabolites in biological fluids.

  Journal of chromatography. B, Biomedical sciences and applications 20010425

• Mycobacterial FurA is a negative regulator of catalase-peroxidase gene katG.

  Molecular microbiology 20010301

• Alternative splicing of a Drosophila GABA receptor subunit gene identifies determinants of agonist potency.

  Neuroscience 20010101

• Molecularly imprinted polymers from nicotinamide and its positional isomers.

  Journal of molecular recognition : JMR 20010101

• Characterisation and partial purification of the GABA(B) receptor from the rat cerebellum using the novel antagonist [3H]CGP 62349.

  Brain research. Molecular brain research 19990825

• 2-Hydroxyisonicotinate dehydrogenase isolated from Mycobacterium sp. INA1.

  FEMS microbiology letters 19980715

• Catabolism of isonicotinate by Mycobacterium sp. INA1: extended description of the pathway and purification of the molybdoenzyme isonicotinate dehydrogenase.

  Journal of general microbiology 19931101

• Action of 1-isonicotinyl-2-palmitoyl hydrazine against the Mycobacterium avium complex and enhancement of its activity by m-fluorophenylalanine.

  Antimicrobial agents and chemotherapy 19901101

• Metabolism of isoniazid & related compounds by microorganisms: isolation, characterization & growth of isoniazid-degrading organism.

  Indian journal of experimental biology 19781001

• Mode of action and quantitative structure-activity correlations of tuberculostatic drugs of the isonicotinic acid hydrazide type.

  Journal of medicinal chemistry 19760401

• [Use of B6, B1, B12 vitamins in polyneuritis due to the use of isonicotinic acid hydrazine].

  Hospital (Rio de Janeiro, Brazil) 19700201

• [Chemical studies the mechanism of action of isoniazid].

  Arzneimittel-Forschung 19661101