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XIAP inhibitor embelin induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells.
Environmental toxicology 20171101
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Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors.
The Journal of pharmacology and experimental therapeutics 20140501
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Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways.
PloS one 20140101
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Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Bioorganic & medicinal chemistry 20121115
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Antioxidant activity and protection of pancreatic β-cells by embelin in streptozotocin-induced diabetes.
Journal of diabetes 20120901
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Combination therapy of antiandrogen and XIAP inhibitor for treating advanced prostate cancer.
Pharmaceutical research 20120801
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Inhibition of UVB-induced oxidative damage and apoptotic biochemical changes in human lymphocytes by 2,5-dihydroxy-3-undecyl-1,4-benzoquinone (embelin).
International journal of radiation biology 20120801
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PEG-derivatized embelin as a dual functional carrier for the delivery of paclitaxel.
Bioconjugate chemistry 20120718
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XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells.
Molecular cancer therapeutics 20120701
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Co-expression of XIAP and cyclin D1 complex correlates with a poor prognosis in patients with hepatocellular carcinoma.
The American journal of pathology 20120501
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Preventive effect of embelin from embelia ribes on lipid metabolism and oxidative stress in high-fat diet-induced obesity in rats.
Planta medica 20120501
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Inhibition of X-linked inhibitor of apoptosis with embelin differentially affects male versus female behavioral outcome following neonatal hypoxia-ischemia in rats.
Developmental neuroscience 20120301
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Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells.
Medical oncology (Northwood, London, England) 20111201
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Protective effect of embelin from Embelia ribes Burm. against transient global ischemia-induced brain damage in rats.
Neurotoxicity research 20111101
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Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN.
Cancer letters 20110901
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Embelin reduces cutaneous TNF-α level and ameliorates skin edema in acute and chronic model of skin inflammation in mice.
European journal of pharmacology 20110715
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Embelin ameliorates dextran sodium sulfate-induced colitis in mice.
International immunopharmacology 20110601
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RP-HPLC-DAD method for the estimation of embelin as marker in Embelia ribes and its polyherbal formulations.
Biomedical chromatography : BMC 20110501
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Protective effect of embelin against acetic acid induced ulcerative colitis in rats.
European journal of pharmacology 20110301
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Anticonvulsant activity of embelin isolated from Embelia ribes.
Phytomedicine : international journal of phytotherapy and phytopharmacology 20110115
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Synthesis and evaluation of analgesic and anti-inflammatory activities of most active free radical scavenging derivatives of embelin-A structure-activity relationship.
Chemical & pharmaceutical bulletin 20110101
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Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 20101101
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Synthesis and characterization of amphiphilic lipopolymers for micellar drug delivery.
Biomacromolecules 20101011
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Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling.
The Journal of pathology 20101001
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Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathway.
Molecular cancer research : MCR 20101001
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Activation of endothelial nitric oxide synthase by the pro-apoptotic drug embelin: Striking discrepancy between nitric oxide-mediated cyclic GMP accumulation and L-citrulline formation.
Nitric oxide : biology and chemistry 20100515
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X-linked inhibitor of apoptosis protein inhibits apoptosis in inflammatory breast cancer cells with acquired resistance to an ErbB1/2 tyrosine kinase inhibitor.
Molecular cancer therapeutics 20100501
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Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin-induced apoptosis.
Molecular carcinogenesis 20100401
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XIAP-mediated protection of H460 lung cancer cells against cisplatin.
European journal of pharmacology 20100210
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Chemopreventive and hepatoprotective effects of embelin on N-nitrosodiethylamine and carbon tetrachloride induced preneoplasia and toxicity in rat liver.
Asian Pacific journal of cancer prevention : APJCP 20100101
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The XIAP inhibitor Embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP.
Neurochemistry international 20091101
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Effects of embelin on lipid peroxidation and free radical scavenging activity against liver damage in rats.
Basic & clinical pharmacology & toxicology 20091001
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Micellar delivery of bicalutamide and embelin for treating prostate cancer.
Pharmaceutical research 20090901
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Peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of Embelin on colon carcinogenesis.
Cancer research 20090601
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Inhibitory effects of antrodins A-E from Antrodia cinnamomea and their metabolites on hepatitis C virus protease.
Phytotherapy research : PTR 20090401
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Triterpenes from Cynomorium songaricium--analysis of HCV protease inhibitory activity, quantification, and content change under the influence of heating.
Journal of natural medicines 20090101
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Cell-penetrating peptide-conjugated XIAP-inhibitory cyclic hexapeptides enter into Jurkat cells and inhibit cell proliferation.
The FEBS journal 20081201
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Activity of 1,4-benzoquinones against formosan subterranean termites (Coptotermes formosanus).
Journal of agricultural and food chemistry 20080611
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Protein-protein recognition as a first step towards the inhibition of XIAP and Survivin anti-apoptotic proteins.
Journal of molecular recognition : JMR 20080101
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Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells.
The Journal of surgical research 20071001
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Free radical scavenging reactions and antioxidant activity of embelin: biochemical and pulse radiolytic studies.
Chemico-biological interactions 20070425
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Wound healing activity of embelin isolated from the ethanol extract of leaves of Embelia ribes Burm.
Journal of ethnopharmacology 20070212
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Microwave-assisted extraction of embelin from Embelia ribes.
Biotechnology letters 20070201
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Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products.
Molecular pharmacology 20070101
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Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein.
Bioorganic & medicinal chemistry letters 20061115
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Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
Journal of molecular graphics & modelling 20061101
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A nitrogen-containing 3-alkyl-1,4-benzoquinone and a gomphilactone derivative from Embelia ribes.
Journal of natural products 20061101
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Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
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Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats.
Molecular and cellular biochemistry 20060301
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Cell death in pancreatitis: caspases protect from necrotizing pancreatitis.
The Journal of biological chemistry 20060210
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Embelin derivatives and their anticancer activity through microtubule disassembly.
Planta medica 20051001
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Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats.
Fitoterapia 20050901
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Cytotoxic activity of embelin from Lysimachia punctata.
Fitoterapia 20050601
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Anti-fertility effects of embelin in female Sprague-Dawley rats may be due to suppression of ovarian function.
Acta biologica Hungarica 20050101
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Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.
Journal of medicinal chemistry 20040506
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Bioactive alkyl phenols and embelin from Oxalis erythrorhiza.
Journal of ethnopharmacology 20031001
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Electrochemically synthesized polymer of the plant substance embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone).
Applied biochemistry and biotechnology 20010101
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Inhibitory effects of sudanese medicinal plant extracts on hepatitis C virus (HCV) protease.
Phytotherapy research : PTR 20001101
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Steroid hormone activity of flavonoids and related compounds.
Breast cancer research and treatment 20000701
