-
Novel miRNA biomarkers for genotoxicity screening in mouse.
Toxicology 20180701
-
Yangonin protects against cholestasis and hepatotoxity via activation of farnesoid X receptor in vivo and in vitro.
Toxicology and applied pharmacology 20180601
-
Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption.
Toxicology 20170701
-
Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.
Archives of toxicology 20170501
-
Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis.
Toxicology 20170215
-
Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury.
Archives of toxicology 20170101
-
Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach.
Archives of toxicology 20170101
-
Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development.
Toxicology letters 20161130
-
Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice.
Toxicology and applied pharmacology 20160901
-
Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes.
Toxicology 20160831
-
Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats.
Toxicology and applied pharmacology 20160815
-
Promising toxicological biomarkers for the diagnosis of liver injury types: Bile acid metabolic profiles and oxidative stress marker as screening tools in drug development.
Chemico-biological interactions 20160805
-
Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease.
Toxicology 20160715
-
Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism.
Blood 20160602
-
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.
Chemical research in toxicology 20160321
-
Onset of hepatocarcinogen-specific cell proliferation and cell cycle aberration during the early stage of repeated hepatocarcinogen administration in rats.
Journal of applied toxicology : JAT 20160201
-
Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs.
Toxicological sciences : an official journal of the Society of Toxicology 20150601
-
Alisol B 23-acetate protects against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes involved in bile acid homeostasis.
Toxicology and applied pharmacology 20150315
-
Resveratrol effectively attenuates α-naphthyl-isothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms.
Acta pharmacologica Sinica 20141201
-
Differential Fmo3 gene expression in various liver injury models involving hepatic oxidative stress in mice.
Toxicology 20141105
-
Comparative gene and protein expression analyses of a panel of cytokines in acute and chronic drug-induced liver injury in rats.
Toxicology 20141003
-
The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury.
The Journal of pharmacology and experimental therapeutics 20140601
-
Metabolomic analysis of arginine metabolism in acute hepatic injury in rats.
The Journal of toxicological sciences 20140201
-
Alpha-naphthylisothiocyanate modulates hepatobiliary transporters in sandwich-cultured rat hepatocytes.
Toxicology letters 20140103
-
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
PloS one 20140101
-
Genomic biomarkers for cardiotoxicity in rats as a sensitive tool in preclinical studies.
Journal of applied toxicology : JAT 20131001
-
Evaluation of miR-122 and other biomarkers in distinct acute liver injury in rats.
Toxicologic pathology 20130701
-
Expression patterns of cell cycle proteins in the livers of rats treated with hepatocarcinogens for 28 days.
Archives of toxicology 20130601
-
Loss of A(1) adenosine receptor attenuates alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice.
Toxicological sciences : an official journal of the Society of Toxicology 20130101
-
Changes of pharmacokinetics of 6,7-dimethoxycoumarin in a rat model of alpha-naphthylisothiocyanate-induced experimental hepatic injury after Yinchenhao Decoction () treatment.
Chinese journal of integrative medicine 20121101
-
Effect of JBP485 on obstructive jaundice is related to regulation of renal Oat1, Oat3 and Mrp2 expression in ANIT-treated rats.
Peptides 20120701
-
Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity.
Toxicology and applied pharmacology 20120601
-
Genetic Variations in TXNRD1 as Potential Predictors of Drug-Induced Liver Injury.
Allergy, asthma & immunology research 20120501
-
Metabolic profiling of the rat liver after chronic ingestion of alpha-naphthylisothiocyanate using in vivo and ex vivo magnetic resonance spectroscopy.
Toxicological sciences : an official journal of the Society of Toxicology 20120401
-
Protective effect of Danning tablet on acute livery injury with cholestasis induced by α-naphthylisothiocyanate in rats.
Journal of ethnopharmacology 20120327
-
Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis in mice.
Toxicological sciences : an official journal of the Society of Toxicology 20120301
-
Mechanism of exacerbative effect of progesterone on drug-induced liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 20120301
-
Comparative pharmacokinetic study of paeoniflorin and albiflorin after oral administration of Radix Paeoniae Rubra in normal rats and the acute cholestasis hepatitis rats.
Fitoterapia 20120301
-
Effect of alpha-naphthylisothiocyanate-induced liver injury on intestinal adaptation in a rat model of short bowel syndrome.
Pediatric surgery international 20120201
-
Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis.
Gastroenterology 20120201
-
Suppression of the HPA axis during extrahepatic biliary obstruction induces cholangiocyte proliferation in the rat.
American journal of physiology. Gastrointestinal and liver physiology 20120101
-
Plasma microRNA profiles in rat models of hepatocellular injury, cholestasis, and steatosis.
PloS one 20120101
-
Identification of biomarkers of chemically induced hepatocarcinogenesis in rasH2 mice by toxicogenomic analysis.
Archives of toxicology 20111201
-
Pathogenesis of primary sclerosing cholangitis.
Best practice & research. Clinical gastroenterology 20111201
-
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
PLoS computational biology 20111201
-
1-[(Ferrocen-1-yl)meth-yl]-3-(naphthalen-1-yl)thio-urea.
Acta crystallographica. Section E, Structure reports online 20111201
-
Immunohistochemical characterization of macrophages and myofibroblasts in α-Naphthylisothiocyanate (ANIT)--induced bile duct injury and subsequent fibrogenesis in rats.
Toxicologic pathology 20110801
-
Evaluation study on urine metabolomics in yinhuang rat model induced by triplet factors of rhubarb, ethanol, and α-nephthylisothiolyanate.
Chinese journal of integrative medicine 20110501
-
Fibrosis in autoimmune and cholestatic liver disease.
Best practice & research. Clinical gastroenterology 20110401
-
Fibrinogen deficiency increases liver injury and early growth response-1 (Egr-1) expression in a model of chronic xenobiotic-induced cholestasis.
The American journal of pathology 20110301
-
Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice.
Toxicology and applied pharmacology 20110201
-
Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 20110101
-
Measuring size-dependent permeability of the tight junction using PEG profiling.
Methods in molecular biology (Clifton, N.J.) 20110101
-
Hepatotoxicity or hepatoprotection? Pattern recognition for the paradoxical effect of the Chinese herb Rheum palmatum L. in treating rat liver injury.
PloS one 20110101
-
Existence of inverted profile in chemically responsive molecular pathways in the zebrafish liver.
PloS one 20110101
-
Protective effects of Moutan Cortex Radicis against acute hepatotoxicity.
African journal of traditional, complementary, and alternative medicines : AJTCAM 20110101
-
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug metabolism and disposition: the biological fate of chemicals 20101201
-
The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis.
The American journal of pathology 20101201
-
Interleukin-17 is involved in alpha-naphthylisothiocyanate-induced liver injury in mice.
Toxicology 20100910
-
Time course gene expression using laser capture microscopy-extracted bile ducts, but not hepatic parenchyma, reveals acute alpha-naphthylisothiocyanate toxicity.
Toxicologic pathology 20100801
-
Acute ANIT toxicity in male IL-10 knockout and wild-type mice.
Toxicologic pathology 20100801
-
Increased intestinal absorption of mizoribine, an immunosuppressive agent, in cholestatic rats.
Die Pharmazie 20100701
-
Metabolic Fingerprinting in Toxicological Assessment Using FT-ICR MS.
Journal of toxicologic pathology 20100601
-
Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies.
Toxicological sciences : an official journal of the Society of Toxicology 20100501
-
Evaluation of a liver micronucleus assay in young rats (III): a study using nine hepatotoxicants by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS).
Mutation research 20100430
-
[Effect of emodin on P-gp expression in intrahepatic cholestatic rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100401
-
Identification of urinary biomarkers useful for distinguishing a difference in mechanism of toxicity in rat model of cholestasis.
Basic & clinical pharmacology & toxicology 20090901
-
Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.
Toxicological sciences : an official journal of the Society of Toxicology 20090701
-
Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation.
Hepatology (Baltimore, Md.) 20090701
-
Investigations of free anthraquinones from rhubarb against alpha-naphthylisothiocyanate-induced cholestatic liver injury in rats.
Basic & clinical pharmacology & toxicology 20090601
-
Comparative study on the protective effects of Yinchenhao Decoction against liver injury induced by alpha-naphthylisothiocyanate and carbon tetrachloride.
Chinese journal of integrative medicine 20090601
-
Quantitative analysis of valiolamine through pre-column derivatization with phenylisocyanate using high-performance liquid chromatography with UV detection: selection of reagent, identification of derivative and optimization of derivatization conditions.
Journal of pharmaceutical and biomedical analysis 20090501
-
[Effect and mechanism of emodin on cholestatic hepatitis].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20090501
-
Characterization of the enhancing effect of protamine on the proliferative activity of hepatocyte growth factor in rat hepatocytes.
Pharmaceutical research 20090401
-
Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice.
American journal of physiology. Gastrointestinal and liver physiology 20090401
-
ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling.
Toxicological sciences : an official journal of the Society of Toxicology 20090401
-
Gene expression profiling in rat liver treated with compounds inducing elevation of bilirubin.
Human & experimental toxicology 20090401
-
[Therapeutic effects of emodin on acute cholestatic hepatitis and mechanism thereof: experiment with rats].
Zhonghua yi xue za zhi 20090317
-
The impact of new research technologies on our understanding of environmental causes of disease: the concept of clinical vulnerability.
Environmental health : a global access science source 20090101
-
Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles.
PloS one 20090101
-
Raman spectral signatures of human liver perfusates correlate with oxidation reduction potential.
Molecular medicine reports 20090101
-
Monitoring healthy metabolic trajectories with nutritional metabonomics.
Nutrients 20090101
-
Modulation of the inflammatory response and apoptosis using epidermal growth factor and hepatocyte growth factor in a liver injury model: a potential approach to the management and treatment of cholestatic liver disease.
Journal of pediatric surgery 20081201
-
Bile acids metabonomic study on the CCl4- and alpha-naphthylisothiocyanate-induced animal models: quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry.
Chemical research in toxicology 20081201
-
Urinary metabolic fingerprinting for alpha-naphthylisothiocyanate-induced intrahepatic cholestasis in rats using Fourier transform-ion cyclotron resonance mass spectrometry.
Toxicologic pathology 20081001
-
In vivo effect of selective macrophage suppression on the development of intrahepatic cholestasis in mice.
Bulletin of experimental biology and medicine 20081001
-
Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway.
European journal of pharmacology 20080820
-
A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats.
Toxicology 20080819
-
Activity of lysosomal enzymes in the bile and serum of mice with intrahepatic cholestasis.
Bulletin of experimental biology and medicine 20080501
-
Validation of putative genomic biomarkers of nephrotoxicity in rats.
Toxicology 20080418
-
Integration of clinical chemistry, expression, and metabolite data leads to better toxicological class separation.
Toxicological sciences : an official journal of the Society of Toxicology 20080401
-
Protective response of the Ah receptor to ANIT-induced biliary epithelial cell toxicity in see-through medaka.
Toxicological sciences : an official journal of the Society of Toxicology 20080401
-
[Role of early growth response factor-1 signal pathway in acute intrahepatic cholestatic hepatic injury in rats].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20080301
-
Hepatoprotective effect of Hypericum japonicum extract and its fractions.
Journal of ethnopharmacology 20080227
-
Seizure susceptibility alteration following reversible cholestasis in mice: Modulation by opioids and nitric oxide.
European journal of pharmacology 20080212
-
Integrative top-down system metabolic modeling in experimental disease states via data-driven Bayesian methods.
Journal of proteome research 20080201
-
Non invasive high resolution in vivo imaging of alpha-naphthylisothiocyanate (ANIT) induced hepatobiliary toxicity in STII medaka.
Aquatic toxicology (Amsterdam, Netherlands) 20080120
-
Piecewise multivariate modelling of sequential metabolic profiling data.
BMC bioinformatics 20080101
-
A CD133-expressing murine liver oval cell population with bilineage potential.
Stem cells (Dayton, Ohio) 20071001
-
Acute hepatotoxicity: a predictive model based on focused illumina microarrays.
Toxicological sciences : an official journal of the Society of Toxicology 20070901
-
Uniform procedure of (1)H NMR analysis of rat urine and toxicometabonomics Part II: comparison of NMR profiles for classification of hepatotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 20070701
-
Bone marrow fails to differentiate into liver epithelium during murine development and regeneration.
Hepatology (Baltimore, Md.) 20070501
-
Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells.
Toxicological sciences : an official journal of the Society of Toxicology 20070301
-
Melatonin attenuates disruption of serum cholesterol status in rats with a single alpha-naphthylisothiocyanate treatment.
Journal of pineal research 20070301
-
Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats.
Toxicology 20070212
-
Protective effect of glycyrrhizin, glycyrrhetic acid and matrine on acute cholestasis induced by alpha-naphthyl isothiocyanate in rats.
Planta medica 20070201
-
Protective effect of glycyrrhizin and matrine on acute vanishing bile duct syndrome induced by alpha-naphthylisothiocyanate in rats.
Hepatology research : the official journal of the Japan Society of Hepatology 20070201
-
Determination and kinetics of producing glucosamine using fungi.
Biotechnology progress 20070101
-
Saikokeishito Extract Exerts a Therapeutic Effect on alpha-Naphthylisothiocyanate-Induced Liver Injury in Rats through Attenuation of Enhanced Neutrophil Infiltration and Oxidative Stress in the Liver Tissue.
Journal of clinical biochemistry and nutrition 20070101
-
Investigation of the hepatotoxicity profile of chemical entities using Liverbeads and WIF-B9 in vitro models.
Toxicology in vitro : an international journal published in association with BIBRA 20060901
-
ANIT toxicity toward mouse hepatocytes in vivo is mediated primarily by neutrophils via CD18.
American journal of physiology. Gastrointestinal and liver physiology 20060801
-
Heterogeneity of the intrahepatic biliary epithelium.
World journal of gastroenterology 20060614
-
alpha-Tocopherol protects against alpha-naphthylisothiocyanate-induced hepatotoxicity in rats less effectively than melatonin.
Chemico-biological interactions 20060610
-
Lack of evidence that bone marrow cells contribute to cholangiocyte repopulation during experimental cholestatic ductal hyperplasia.
Liver international : official journal of the International Association for the Study of the Liver 20060501
-
Analysis of kanamycin A in human plasma and in oral dosage form by derivatization with 1-naphthyl isothiocyanate and high-performance liquid chromatography.
Journal of separation science 20060301
-
The potential risks of nanomaterials: a review carried out for ECETOC.
Particle and fibre toxicology 20060101
-
Characterization of ANIT-induced toxicity using precision-cut rat and dog liver slices cultured in a dynamic organ roller system.
Toxicologic pathology 20060101
-
Liquid chromatography-mass spectrometric analysis of urinary metabolites and their pattern recognition for the prediction of drug-induced hepatotoxicity.
Chemical research in toxicology 20051201
-
NMR spectroscopic-based metabonomic investigation on the acute biochemical effects induced by Ce(NO3)3 in rats.
Journal of inorganic biochemistry 20051101
-
Pharmacokinetics of alpha-naphthyl isothiocyanate in rats.
Journal of pharmaceutical sciences 20051101
-
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
Clinical chemistry 20051001
-
Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action.
Journal of biotechnology 20050929
-
Chemometric analysis of biofluids following toxicant induced hepatotoxicity: a metabonomic approach to distinguish the effects of 1-naphthylisothiocyanate from its products.
Xenobiotica; the fate of foreign compounds in biological systems 20050801
-
Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation.
World journal of gastroenterology 20050721
-
Limited protective role of V-PYRRO/NO against cholestasis produced by alpha-naphthylisothiocyanate in mice.
Biochemical pharmacology 20050701
-
Biliary excretion of taurocholate, organic anions and vinblastine in rats with alpha-naphthylisothiocyanate-induced cholestasis.
Journal of gastroenterology and hepatology 20050701
-
Effect of alpha-naphthyl isothiocyanate on 2-amino-3-methylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats.
International journal of cancer 20050620
-
Effect of betaine supplementation on changes in hepatic metabolism of sulfur-containing amino acids and experimental cholestasis induced by alpha-naphthylisothiocyanate.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050501
-
Comparison of metabolic profiles from serum from hepatotoxin-treated rats by nuclear-magnetic-resonance-spectroscopy-based metabonomic analysis.
Analytical biochemistry 20050501
-
Studies on the acute biochemical effects of La(NO3)3 using 1H NMR spectroscopy of urine combined with pattern recognition.
Journal of inorganic biochemistry 20050201
-
Identification of 4-methylspinaceamine--a Pictet-Spengler condensation reaction product of histamine with acetaldehyde--in human urine.
Life sciences 20050128
-
Effects of alpha-naphthyl isothiocyanate and a heterocyclic amine, PhIP, on cytochrome P-450, mutagenic activation of various carcinogens and glucuronidation in rat liver.
Mutagenesis 20050101
-
In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid.
Journal of medicinal food 20050101
-
Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injury.
American journal of physiology. Gastrointestinal and liver physiology 20040901
-
Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines.
Experimental biology and medicine (Maywood, N.J.) 20040901
-
Discriminating different classes of toxicants by transcript profiling.
Environmental health perspectives 20040801
-
Effects of benzyl-, phenethyl-, and alpha-naphthyl isothiocyanates on P-glycoprotein- and MRP1-mediated transport.
Journal of pharmaceutical sciences 20040701
-
Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver.
Biochemical pharmacology 20040601
-
Development of a LC-MS/MS method for the analysis of volatile primary and secondary amines as NIT (naphthylisothiocyanate) derivatives.
Analytical and bioanalytical chemistry 20040201
-
Hepatotoxin-induced hypercreatinaemia and hypercreatinuria: their relationship to one another, to liver damage and to weakened nutritional status.
Archives of toxicology 20040201
-
Effects of feeding and body weight loss on the 1H-NMR-based urine metabolic profiles of male Wistar Han rats: implications for biomarker discovery.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20040101
-
[6,8-Dimethyl-2-piperidinomethyl-2,3-dihydrothiazolo[2,3-f]xanthine: a new inductor of the monooxygenase system inhibits experimental intrahepatic cholestasis in rats].
Eksperimental'naia i klinicheskaia farmakologiia 20040101
-
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.
The Journal of clinical investigation 20031201
-
Use of a low-density microarray for studying gene expression patterns induced by hepatotoxicants on primary cultures of rat hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 20031001
-
Toward the identification of liver toxicity markers: a proteome study in human cell culture and rats.
Proteomics 20031001
-
Assessment of hepatocytes and liver slices as in vitro test systems to predict in vivo gene expression.
Toxicological sciences : an official journal of the Society of Toxicology 20030901
-
Glucocorticoid receptors are downregulated in hepatic T lymphocytes in rats with experimental cholangitis.
Gut 20030901
-
Histological changes and impairment of liver mitochondrial bioenergetics after long-term treatment with alpha-naphthyl-isothiocyanate (ANIT).
Toxicology 20030828
-
Glutathione depletion exacerbates methylenedianiline toxicity to biliary epithelial cells and hepatocytes in rats.
Toxicological sciences : an official journal of the Society of Toxicology 20030801
-
A metabonomic investigation of hepatotoxicity using diffusion-edited 1H NMR spectroscopy of blood serum.
The Analyst 20030701
-
Determination of alpha-naphthylisothiocyanate and metabolites alpha-naphthylamine and alpha-naphthylisocyanate in rat plasma and urine by high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030505
-
Preventive effect of melatonin on the progression of alpha-naphthylisothiocyanate-induced acute liver injury in rats.
Journal of pineal research 20030401
-
Hepatic artery and portal vein remodeling in rat liver: vascular response to selective cholangiocyte proliferation.
The American journal of pathology 20030401
-
Cholestasis induced by chronic treatment with alpha-naphthyl-isothiocyanate (ANIT) affects rat renal mitochondrial bioenergetics.
Archives of toxicology 20030401
-
An hypothesis for a mechanism underlying hepatotoxin-induced hypercreatinuria.
Archives of toxicology 20030401
-
Cardiac mitochondrial calcium loading capacity is severely affected after chronic cholestasis in Wistar rats.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20030301
-
Reduction in cardiac mitochondrial calcium loading capacity is observable during alpha-naphthylisothiocyanate-induced acute cholestasis: a clue for hepatic-derived cardiomyopathies?
Biochimica et biophysica acta 20030120
-
Chronic cholestasis and cardiac mitochondrial function in Wistar rats: a model for cardiovascular alterations in chronic liver disease?
Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20030101
-
Cholestasis: human disease and experimental animal models.
Annals of hepatology 20030101
-
Trace analysis of tobramycin in human plasma by derivatization and high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021125
-
Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine.
Pharmaceutical research 20021001
-
Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis.
Bulletin of experimental biology and medicine 20020901
-
Functional heterogeneity of cholangiocytes.
Seminars in liver disease 20020801
-
NMR and pattern recognition studies on liver extracts and intact livers from rats treated with alpha-naphthylisothiocyanate.
Biochemical pharmacology 20020701
-
Improved efficiency of hepatic mitochondrial function in rats with cholestasis induced by an acute dose of alpha-naphthylisothiocyanate.
Toxicology and applied pharmacology 20020701
-
Experimental colitis attenuates development of toxin-induced cholangitis in rats.
Digestive diseases and sciences 20020601
-
Disruption of mitochondrial calcium homeostasis after chronic alpha-naphthylisothiocyanate administration: relevance for cholestasis.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20020501
-
Preventive effect of the Taiwan folk medicine Ixeris laevigata var. oldhami on alpha-naphthyl-isothiocyanate and carbon tetrachloride-induced acute liver injury in rats.
Phytotherapy research : PTR 20020301
-
Metabolic trajectory characterisation of xenobiotic-induced hepatotoxic lesions using statistical batch processing of NMR data.
The Analyst 20020201
-
Alpha-glutathione S-transferase in the assessment of hepatotoxicity--its diagnostic utility in comparison with other recognized markers in the Wistar Han rat.
Toxicologic pathology 20020101
-
High performance liquid chromatographic determination of glucosamine in rat plasma.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20020101
-
Prophylactic effect of four prescriptions of traditional Chinese medicine on alpha-naphthylisothiocyanate and carbon tetrachloride induced toxicity in rats.
Acta pharmacologica Sinica 20011201
-
Effect of melatonin on changes in hepatic antioxidant enzyme activities in rats treated with alpha-naphthylisothiocyanate.
Journal of pineal research 20011101
-
Role of MRP2 and GSH in intrahepatic cycling of toxins.
Toxicology 20011005
-
NMR and pattern recognition studies on the time-related metabolic effects of alpha-naphthylisothiocyanate on liver, urine, and plasma in the rat: an integrative metabonomic approach.
Chemical research in toxicology 20011001
-
Regression of cholangiocyte proliferation after cessation of ANIT feeding is coupled with increased apoptosis.
American journal of physiology. Gastrointestinal and liver physiology 20010701
-
Quantitative assessment of the rat intrahepatic biliary system by three-dimensional reconstruction.
The American journal of pathology 20010601
-
[Study on hepatic-protective effect of 'yinzhihuang' granula].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20010501
-
Regulation of cholangiocyte proliferation.
Liver 20010401
-
Determination of morpholine in air by derivatisation with 1-naphthylisothiocyanate and HPLC analysis.
The Analyst 20010201
-
Characterization of the protective effects of melatonin and related indoles against alpha-naphthylisothiocyanate-induced liver injury in rats.
Journal of cellular biochemistry 20010101
-
Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants.
Toxicological sciences : an official journal of the Society of Toxicology 20001001
-
ANIT-induced disruption of biliary function in rat hepatocyte couplets.
Toxicological sciences : an official journal of the Society of Toxicology 19990201
-
Cytotoxicity of naphthylisothiocyanates in rat hepatocyte-neutrophil cocultures.
Toxicology letters 19980501
-
Naphthylisothiocyanate disposition in bile and its relationship to liver glutathione and toxicity.
Biochemical pharmacology 19951026
-
Leukotrienes and alpha-naphthylisothiocyanate-induced liver injury.
Toxicology 19950626
-
Cholestatic potentials of alpha-naphthylisothiocyanate (ANIT) and beta-naphthylisothiocyanate (BNIT) in the isolated perfused rat liver.
Biochemical pharmacology 19931203
-
Lack of benefit of ursodeoxycholic acid in drug-induced cholestasis in the rat.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19920501
-
Relationship between alpha-naphthylisothiocyanate-induced liver injury and elevations in hepatic non-protein sulfhydryl content.
Biochemical pharmacology 19910822
-
Increased paracellular permeability in intrahepatic cholestasis induced by carmustine (BCNU) in rats.
Gastroenterology 19910701
-
Drug-induced intrahepatic cholestasis: characterization of different pathomechanisms.
Archives of toxicology 19870101
-
Hepatic levels of cytosolic, microsomal and 'mitochondrial' epoxide hydrolases and other drug-metabolizing enzymes after treatment of mice with various xenobiotics and endogenous compounds.
Chemico-biological interactions 19870101
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No increase of biliary permeability in ethinylestradiol-treated rats.
Gastroenterology 19831001
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Effect of various factors on the induction of liver tumors in animals by quinoline.
Gan 19771201