553-03-7 | 3,4-Dihydro-2(1H)-quinolinone

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$14.00	$10.00
10g	98%	in stock	$19.00	$14.00
25g	98%	in stock	$34.00	$24.00
100g	98%	in stock	$99.00	$69.00

Description

• Catalog Number: AB63718
• Chemical Name: 3,4-Dihydro-2(1H)-quinolinone
• CAS Number: 553-03-7
• Molecular Formula: C9H9NO
• Molecular Weight: 147.1739
• MDL Number: MFCD00016722
• SMILES: O=C1CCc2c(N1)cccc2
• NSC Number: 49170

Computed Properties

• Complexity: 167
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• XLogP3: 1.1

Literature

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  Acta crystallographica. Section E, Structure reports online 20120701

• Aflaquinolones A-G: secondary metabolites from marine and fungicolous isolates of Aspergillus spp.

  Journal of natural products 20120323

• Synthesis of tripeptide mimetics based on dihydroquinolinone and benzoxazinone scaffolds.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20111209

• Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.

  Journal of medicinal chemistry 20110811

• 2-(2-Chloro-6,7-dimethyl-quinolin-3-yl)-2,3-dihydro-quinolin-4(1H)-one.

  Acta crystallographica. Section E, Structure reports online 20110801

• Reactive spin state dependent enantiospecific photocyclization of axially chiral α-substituted acrylanilides.

  Chemical communications (Cambridge, England) 20110307

• Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).

  Bioorganic & medicinal chemistry letters 20110301

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

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  Bioorganic & medicinal chemistry letters 20100501

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  Acta crystallographica. Section E, Structure reports online 20091201

• Synthesis of highly enantioenriched 3,4-dihydroquinolin-2-ones by 6-exo-trig radical cyclizations of axially chiral alpha-halo-ortho-alkenyl anilides.

  Journal of the American Chemical Society 20091028

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  Acta crystallographica. Section E, Structure reports online 20091001

• Novel approach to 3,4-dihydro-2(1H)-quinolinone derivatives via cyclopropane ring expansion.

  Organic letters 20090305

• In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.

  Journal of medicinal chemistry 20081225

• Comparison of the bioactivation potential of the antidepressant and hepatotoxin nefazodone with aripiprazole, a structural analog and marketed drug.

  Drug metabolism and disposition: the biological fate of chemicals 20080601

• Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20080315

• Quinoline and derivatives at a tar oil contaminated site: hydroxylated products as indicator for natural attenuation?

  Environmental science & technology 20070801

• Synthesis, biological testing, and binding mode prediction of 6,9-diarylpurin-8-ones as p38 MAP kinase inhibitors.

  Journal of medicinal chemistry 20070503

• Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors.

  Bioorganic & medicinal chemistry letters 20070115

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: Quinolin(di)one and benzazepin(di)one derivatives. herve.geneste@abbott.com.

  Bioorganic & medicinal chemistry letters 20060201

• Synthesis of five-, six-, and seven-membered ring lactams by CpRh complex-catalyzed oxidative N-heterocyclization of amino alcohols.

  Organic letters 20040805

• Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a.

  Bioorganic & medicinal chemistry letters 20031215

• Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter: Part 3. A potential 5-HT transporter imaging agent, 3-(3-[18F]fluoropropyl)-6-nitroquipazine.

  Bioorganic & medicinal chemistry 20031117

• Radical ring closures of 4-isocyanato carbon-centered radicals.

  The Journal of organic chemistry 20030404

• Synthesis of 3-methoxycarbonylmethyl derivatives of dihydroquinolone and dihydrochromenone.

  The Journal of organic chemistry 20010323

• Synthesis and vasorelaxing evaluation of alpha-methylidene-gamma-butyrolactone bearing quinolin-2(1H)-one and 3,4-dihydroquinolin-2(1H)-one derivatives.

  European journal of medicinal chemistry 20010101