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Evaluation of protective effects of costunolide and dehydrocostuslactone on ethanol-induced gastric ulcer in mice based on multi-pathway regulation.
Chemico-biological interactions 20160425
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Guaianolide sesquiterpene lactones, a source to discover agents that selectively inhibit acute myelogenous leukemia stem and progenitor cells.
Journal of medicinal chemistry 20121025
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[Chemical constituents from a portion of ethanolicextract of Saussurea lappa roots].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501
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[Chemical constituents of Dolomiaea souliei].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501
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Induction of Fas-mediated extrinsic apoptosis, p21WAF1-related G2/M cell cycle arrest and ROS generation by costunolide in estrogen receptor-negative breast cancer cells, MDA-MB-231.
Molecular and cellular biochemistry 20120401
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[Study on stability of major pharmaceutical ingredients of vladimiriae radix before and after being roasted in artificial gastric juice, artificial intestinal juice and isolated rat gastric, intestinal or colonic incubation juice].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120301
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Regulatory effects of costunolide on dopamine metabolism-associated genes inhibit dopamine-induced apoptosis in human dopaminergic SH-SY5Y cells.
Neuroscience letters 20120124
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Antimicrobial activity of sesquiterpene lactones isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm.
BMC complementary and alternative medicine 20120101
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Costunolide induces apoptosis in platinum-resistant human ovarian cancer cells by generating reactive oxygen species.
Gynecologic oncology 20111201
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Matrix solid-phase dispersion extraction coupled with HPLC-diode array detection method for the analysis of sesquiterpene lactones in root of Saussurea lappa C.B.Clarke.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110915
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Lettuce costunolide synthase (CYP71BL2) and its homolog (CYP71BL1) from sunflower catalyze distinct regio- and stereoselective hydroxylations in sesquiterpene lactone metabolism.
The Journal of biological chemistry 20110617
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Costunolide stimulates the function of osteoblastic MC3T3-E1 cells.
International immunopharmacology 20110601
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Costunolide inhibits proinflammatory cytokines and iNOS in activated murine BV2 microglia.
Frontiers in bioscience (Elite edition) 20110601
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Quantitative analysis of costunolide and dehydrocostuslactone in rat plasma by ultraperformance liquid chromatography-electrospray ionization-mass spectrometry.
Biomedical chromatography : BMC 20110501
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Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer.
The Journal of urology 20110501
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Costunolide induces apoptosis in human endometriotic cells through inhibition of the prosurvival Akt and nuclear factor kappa B signaling pathway.
Biological & pharmaceutical bulletin 20110101
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Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells.
Radiation oncology (London, England) 20110101
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Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation.
PloS one 20110101
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Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana.
PloS one 20110101
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Antioxidant activity of costunolide and eremanthin isolated from Costus speciosus (Koen ex. Retz) Sm.
Chemico-biological interactions 20101205
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Costunolide-induced apoptosis in human leukemia cells: involvement of c-jun N-terminal kinase activation.
Biological & pharmaceutical bulletin 20091001
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Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae).
Journal of ethnopharmacology 20090730
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Normo-glycemic and hypolipidemic effect of costunolide isolated from Costus speciosus (Koen ex. Retz.)Sm. in streptozotocin-induced diabetic rats.
Chemico-biological interactions 20090515
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Genepolide, a sesterpene gamma-lactone with a novel carbon skeleton from mountain wormwood (Artemisia umbelliformis).
Journal of natural products 20090327
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Effects of a hexane extract from Laurus novocanariensis leaves on the ethanol metabolism of Wistar rats.
Fitoterapia 20090301
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Use of self-organizing maps and molecular descriptors to predict the cytotoxic activity of sesquiterpene lactones.
European journal of medicinal chemistry 20081001
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Costunolide-induced apoptosis is caused by receptor-mediated pathway and inhibition of telomerase activity in NALM-6 cells.
Biological & pharmaceutical bulletin 20080501
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Reversal of cocaine-induced planarian behavior by parthenolide and related sesquiterpene lactones.
Pharmacology, biochemistry, and behavior 20080401
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Melanogenesis inhibitory compounds from Saussureae Radix.
Archives of pharmacal research 20080301
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Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20071201
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Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp.
The Journal of antimicrobial chemotherapy 20070301
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Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells.
Cancer letters 20070208
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Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA.
Bioorganic & medicinal chemistry letters 20061101
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Synthesis of 13-amino costunolide derivatives as anticancer agents.
Bioorganic & medicinal chemistry letters 20060815
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Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks.
Journal of medicinal chemistry 20060406
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Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system.
Bioorganic & medicinal chemistry 20060101
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(1)H, (13)C NMR and X-ray crystallographic studies of highly polyhalogenated derivatives of costunolide lactone.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051101
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Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells.
Cancer letters 20050928
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Preparative isolation and purification of costunolide and dehydrocostuslactone from Aucklandia lappa Decne by high-speed counter-current chromatography.
Journal of chromatography. A 20050527
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Direct identification and quantitative determination of costunolide and dehydrocostuslactone in the fixed oil of Laurus novocanariensis by 13C-NMR spectroscopy.
Phytochemical analysis : PCA 20050101
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A sesquiterpene lactone, costunolide, interacts with microtubule protein and inhibits the growth of MCF-7 cells.
Chemico-biological interactions 20040115
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Costunolide inhibits interleukin-1beta expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells.
Biochemical and biophysical research communications 20040102
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Cytotoxic sesquiterpene lactones from the root of Saussurea lappa.
Journal of natural products 20030901
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Sesquiterpenes (costunolide and zaluzanin D) isolated from laurel (Laurus nobilis L.) induce cell death and morphological change indicative of apoptotic chromatin condensation in leukemia HL-60 cells.
International journal of molecular medicine 20030801
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Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway.
Cancer letters 20021210
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Costunolide triggers apoptosis in human leukemia U937 cells by depleting intracellular thiols.
Japanese journal of cancer research : Gann 20021201
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Potentiation of 1,25-dihydroxyvitamin D(3)-induced differentiation of human promyelocytic leukemia cells into monocytes by costunolide, a germacranolide sesquiterpene lactone.
Biochemical pharmacology 20021015
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Costunolide induces differentiation of human leukemia HL-60 cells.
Archives of pharmacal research 20020801
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Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome p450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory.
Plant physiology 20020501
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Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, on blood-ethanol elevation in rats: involvement of inhibition of gastric emptying and increase in gastric juice secretion.
Alcohol and alcoholism (Oxford, Oxfordshire) 20020101
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Antimycobacterial plant terpenoids.
Planta medica 20011101
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Apoptosis-Inducing costunolide and a novel acyclic monoterpene from the stem bark of Magnolia sieboldii.
Archives of pharmacal research 20010801
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Costunolide, a sesquiterpene from the stem bark of Magnolia sieboldii, inhibits the RAS-farnesyl-proteintransferase.
Planta medica 20010601
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Inhibition by costunolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1.
Cancer letters 20010310
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Patch test sensitization to Compositae mix, sesquiterpene-lactone mix, Compositae extracts, laurel leaf, Chlorophorin, Mansonone A, and dimethoxydalbergione.
American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 20010301
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Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release.
Biological & pharmaceutical bulletin 20010301
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A sesquiterpene lactone, costunolide, from Magnolia grandiflora inhibits NF-kappa B by targeting I kappa B phosphorylation.
Planta medica 20010301
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A new sesquiterpene lactone from Tsoongiodendron odorum Chun.
Journal of Asian natural products research 20010101
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Allelopathic agents from Cyrtocymura cincta.
Natural product letters 20010101
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Antimycobacterial evaluation of germacranolides.
Phytochemistry 19980901
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Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats.
Cancer research 19950315
