554-57-4 | N-[(2E)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide

Packsize	Purity	Availability	Price	Discounted Price
25mg	98%	in stock	$6.00	$4.00
1g	98%	in stock	$50.00	$35.00
5g	98%	in stock	$117.00	$82.00
10g	98%	in stock	$203.00	$142.00
25g	98%	in stock	$403.00	$282.00
100g	98%	in stock	$946.00	$662.00

Description

• Catalog Number: AG25422
• Chemical Name: N-[(2E)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide
• CAS Number: 554-57-4
• Molecular Formula: C5H8N4O3S2
• Molecular Weight: 236.2720
• MDL Number: MFCD00083416
• SMILES: CC(=O)/N=c\1/sc(nn1C)S(=O)(=O)N
• NSC Number: 758426

Computed Properties

• Complexity: 419
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 0.1

Literature

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• Carbachol-induced fluid movement through methazolamide-sensitive bicarbonate production in rat parotid intralobular ducts: quantitative analysis of fluorescence images using fluorescent dye sulforhodamine under a confocal laser scanning microscope.

  European journal of cell biology 20020901

• Management of essential tremor.

  Current neurology and neuroscience reports 20020701

• Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.

  Bioorganic & medicinal chemistry letters 20020617

• Effects of anion and cation inhibitors and carbonic anhydrase inhibitors upon the activity of the gypsy moth (Lepidoptera: Lymantriidae) nucleo-polyhedrovirus.

  Journal of economic entomology 20020401

• Simulation of the pharmacokinetic profile of methazolamide in blood: effect of erythrocyte carbonic anhydrase binding on drug disposition.

  Pharmaceutical research 20020401

• Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.

  Journal of medicinal chemistry 20020328

• Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.

  Journal of medicinal chemistry 20020117

• Effects of carbonic anhydrase inhibition on the responsiveness of laryngeal receptors in cats to CO2.

  Experimental physiology 20010901

• Increased CO(2) stimulates K/Rb reabsorption mediated by H-K-ATPase in CCD of potassium-restricted rabbit.

  American journal of physiology. Renal physiology 20010801

• Biochemical, histological, and inhibitor studies of membrane carbonic anhydrase in frog gastric acid secretion.

  American journal of physiology. Gastrointestinal and liver physiology 20010701

• Gramicidin-perforated patch analysis on HCO3- secretion through a forskolin-activated anion channel in rat parotid intralobular duct cells.

  The Journal of membrane biology 20010301

• Changes in intraocular pressure associated with topical dorzolamide and oral methazolamide in glaucomatous dogs.

  Veterinary ophthalmology 20010301

• Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.

  Bioorganic & medicinal chemistry letters 20010226

• Cysteine conjugate of methazolamide is metabolized by beta-lyase.

  Journal of pharmaceutical sciences 20010201

• In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics.

  Journal of pharmacokinetics and biopharmaceutics 19990201

• Stevens-Johnson syndrome induced by methazolamide treatment.

  Archives of ophthalmology (Chicago, Ill. : 1960) 19970401

• Methazolamide-induced delirium.

  Pharmacotherapy 19970101

• Colour vision and side-effects during treatment with methazolamide.

  Eye (London, England) 19950101

• Treatment of essential tremor with methazolamide.

  Mayo Clinic proceedings 19911001

• Calcium metabolism in acidotic patients induced by carbonic anhydrase inhibitors: responses to citrate.

  The Journal of urology 19910501

• Organic impotence associated with carbonic anhydrase inhibitor therapy for glaucoma.

  Annals of ophthalmology 19870201

• Methazolamide and acetazolamide in acute mountain sickness.

  Aviation, space, and environmental medicine 19830701

• Methazolamide-induced hepatitis and pure RBC aplasia.

  Archives of internal medicine 19810801

• Blood dyscrasias in patients using methazolamide (neptazane) for glaucoma.

  Ophthalmology 19800401

• Aplastic anemia and agranulocytosis in patients using methazolamide for glaucoma.

  JAMA 19790629

• Nonfatal methazolamide-induced aplastic anemia.

  American journal of ophthalmology 19780701

• Urinary calculus during methazolamide therapy.

  American journal of ophthalmology 19760501

• Urinary calculi with methazolamide therapy.

  Documenta ophthalmologica. Advances in ophthalmology 19730221

• Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors.

  The British journal of ophthalmology 19680801