554-57-4 | N-[(2E)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide

Packsize	Purity	Availability	Price	Discounted Price
25mg	98%	in stock	$15.00	$10.00
100mg	98%	in stock	$19.00	$13.00
250mg	98%	in stock	$25.00	$17.00
1g	98%	in stock	$49.00	$34.00
5g	98%	in stock	$121.00	$85.00
10g	98%	in stock	$201.00	$141.00
25g	98%	in stock	$401.00	$281.00
100g	98%	in stock	$945.00	$661.00

Description

• Catalog Number: AG25422
• Chemical Name: N-[(2E)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide
• CAS Number: 554-57-4
• Molecular Formula: C5H8N4O3S2
• Molecular Weight: 236.272
• MDL Number: MFCD00083416
• SMILES: CC(=O)/N=c1/sc(nn1C)S(=O)(=O)N
• NSC Number: 758426

Computed Properties

• Complexity: 419
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 0.1

Literature

• Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.

  Bioorganic & medicinal chemistry 20131001

• A case of paclitaxel-induced maculopathy treated with methazolamide.

  Korean journal of ophthalmology : KJO 20121001

• Bilateral transient myopia, angle-closure glaucoma, and choroidal detachment induced by methazolamide.

  Japanese journal of ophthalmology 20120901

• Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo.

  Diabetes 20120801

• Impact of hemolysis during sample collection: how different is drug concentration in hemolyzed plasma from that of normal plasma?

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120715

• Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.

  Journal of medicinal chemistry 20120412

• Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.

  Bioorganic & medicinal chemistry 20120215

• Determination of memantine in rat plasma by HPLC-fluorescence method and its application to study of the pharmacokinetic interaction between memantine and methazolamide.

  Biomedical chromatography : BMC 20120201

• Effect of intermittent hypobaric hypoxia on efficacy & clearance of drugs.

  The Indian journal of medical research 20120201

• Design of cationic nanostructured heterolipid matrices for ocular delivery of methazolamide.

  International journal of nanomedicine 20120101

• Pharmacological characterisation of apical Na+ and Cl- transport mechanisms of the anal papillae in the larval mosquito Aedes aegypti.

  The Journal of experimental biology 20111201

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• HLA and Disease Associations in Koreans.

  Immune network 20111201

• Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.

  European journal of medicinal chemistry 20110901

• Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.

  Bioorganic & medicinal chemistry 20110815

• Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.

  Bioorganic & medicinal chemistry 20110615

• Biochemical and molecular characterization of stress-induced β-carbonic anhydrase from a C(4) plant, Pennisetum glaucum.

  Journal of plant physiology 20110415

• Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.

  Bioorganic & medicinal chemistry 20110315

• (R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.

  Bioorganic & medicinal chemistry letters 20110301

• Regulation of anion transport across the uterine epithelium of Gallus domesticus.

  Poultry science 20110301

• A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.

  Bioorganic & medicinal chemistry 20110201

• Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.

  Bioorganic & medicinal chemistry letters 20110115

• Successful treatment of recurrent epithelial ingrowth associated with interface fluid syndrome, flap necrosis, and epithelial defects following LASIK.

  Journal of refractive surgery (Thorofare, N.J. : 1995) 20110101

• A potential new therapeutic system for glaucoma: solid lipid nanoparticles containing methazolamide.

  Journal of microencapsulation 20110101

• The metabolism of methazolamide - identification of metabolites in guinea pig urine.

  Drug metabolism letters 20110101

• Treat ankylosing spondylitis with methazolamide.

  International journal of medical sciences 20110101

• Bacterial carbonic anhydrases as drug targets: toward novel antibiotics?

  Frontiers in pharmacology 20110101

• Addition of a fixed combination of brinzolamide 1%/timolol 0.5% to prostaglandin monotherapy in patients with glaucoma or ocular hypertension.

  Clinical ophthalmology (Auckland, N.Z.) 20110101

• Preparation and evaluation of in situ gelling ophthalmic drug delivery system for methazolamide.

  Drug development and industrial pharmacy 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Cyclodextrin solubilization of carbonic anhydrase inhibitor drugs: formulation of dorzolamide eye drop microparticle suspension.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20101001

• Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.

  European journal of medicinal chemistry 20100901

• Larvae of the midge Chironomus riparius possess two distinct mechanisms for ionoregulation in response to ion-poor conditions.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100901

• Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.

  European journal of medicinal chemistry 20100601

• HLA-B*5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.

  Pharmacogenomics 20100601

• The hypoxia-induced facilitation of augmented breaths is suppressed by the common effect of carbonic anhydrase inhibition.

  Respiratory physiology & neurobiology 20100531

• Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium.

  American journal of physiology. Gastrointestinal and liver physiology 20100501

• Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.

  Journal of medicinal chemistry 20100311

• Methazolamide calcium phosphate nanoparticles in an ocular delivery system.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100301

• Saccharomyces cerevisiae β-carbonic anhydrase: inhibition and activation studies.

  Current pharmaceutical design 20100101

• Overview of essential tremor.

  Neuropsychiatric disease and treatment 20100101

• Safety, tolerability, and efficacy of fixed combination therapy with dorzolamide hydrochloride 2% and timolol maleate 0.5% in glaucoma and ocular hypertension.

  Clinical ophthalmology (Auckland, N.Z.) 20100101

• Increased expression of carbonic anhydrase I in the synovium of patients with ankylosing spondylitis.

  BMC musculoskeletal disorders 20100101

• Involvement of signaling molecules on na/h exchanger-1 activity in human monocytes.

  The open cardiovascular medicine journal 20100101

• Effects of acetazolamide on infantile nystagmus syndrome waveforms: comparisons to contact lenses and convergence in a well-studied subject.

  The open ophthalmology journal 20100101

• Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.

  Bioorganic & medicinal chemistry letters 20091201

• Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy.

  Human molecular genetics 20091101

• Methazolamide does not impair respiratory work performance in anesthetized rabbits.

  American journal of physiology. Regulatory, integrative and comparative physiology 20090901

• Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.

  Bioorganic & medicinal chemistry letters 20090901

• Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.

  Bioorganic & medicinal chemistry 20090715

• Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.

  Bioorganic & medicinal chemistry 20090701

• Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.

  Bioorganic & medicinal chemistry letters 20090601

• Titration calorimetry standards and the precision of isothermal titration calorimetry data.

  International journal of molecular sciences 20090601

• Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.

  Journal of medicinal chemistry 20090514

• Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury.

  Stroke 20090501

• Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.

  Journal of medicinal chemistry 20090423

• QSAR studies for the inhibition of the transmembrane carbonic anhydrase isozyme XIV with sulfonamides using PRECLAV software.

  Journal of enzyme inhibition and medicinal chemistry 20090401

• Studies on bicarbonate transporters and carbonic anhydrase in porcine nonpigmented ciliary epithelium.

  Investigative ophthalmology & visual science 20090401

• Acetazolamide reversibly inhibits water conduction by aquaporin-4.

  Journal of structural biology 20090401

• A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.

  Bioorganic & medicinal chemistry letters 20090301

• Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties.

  Biochemistry 20090217

• Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3.

  American journal of physiology. Gastrointestinal and liver physiology 20090201

• Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.

  Bioorganic & medicinal chemistry 20090201

• Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.

  Bioorganic & medicinal chemistry 20090201

• Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.

  Journal of medicinal chemistry 20090122

• CO2 chemosensing in rat oesophagus.

  Gut 20081201

• Recent advances in pharmacotherapy of glaucoma.

  Indian journal of pharmacology 20081001

• Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080917

• Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.

  Bioorganic & medicinal chemistry letters 20080615

• Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.

  Journal of medicinal chemistry 20080612

• Rational use of the fixed combination of dorzolamide - timolol in the management of raised intraocular pressure and glaucoma.

  Clinical ophthalmology (Auckland, N.Z.) 20080601

• Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.

  Bioorganic & medicinal chemistry letters 20080415

• Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.

  Bioorganic & medicinal chemistry letters 20080415

• Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.

  Bioorganic & medicinal chemistry 20080401

• Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.

  Journal of medicinal chemistry 20080327

• Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).

  Bioorganic & medicinal chemistry letters 20080301

• Pharmacological impact on loop gain properties to prevent irregular breathing.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080301

• Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.

  Bioorganic & medicinal chemistry letters 20080201

• Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.

  Bioorganic & medicinal chemistry letters 20080115

• Carbonic anhydrase II and alveolar fluid reabsorption during hypercapnia.

  American journal of respiratory cell and molecular biology 20080101

• The alpha and beta classes carbonic anhydrases from Helicobacter pylori as novel drug targets.

  Current pharmaceutical design 20080101

• The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents.

  Current pharmaceutical design 20080101

• Alkalinization in the isolated and perfused anterior midgut of the larval mosquito, Aedes aegypti.

  Journal of insect science (Online) 20080101

• Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy.

  British journal of cancer 20071203

• Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.

  Bioorganic & medicinal chemistry 20071201

• Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.

  Bioorganic & medicinal chemistry letters 20070915

• Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.

  Bioorganic & medicinal chemistry letters 20070801

• Carbonic anhydrases as targets for medicinal chemistry.

  Bioorganic & medicinal chemistry 20070701

• Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.

  Bioorganic & medicinal chemistry letters 20070701

• Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.

  Journal of medicinal chemistry 20070405

• PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum.

  American journal of physiology. Gastrointestinal and liver physiology 20070401

• Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition.

  American journal of physiology. Lung cellular and molecular physiology 20070401

• Statement on high-altitude illnesses. An Advisory Committee Statement (ACS).

  Canada communicable disease report = Releve des maladies transmissibles au Canada 20070401

• Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.

  Bioorganic & medicinal chemistry letters 20070315

• Topical inhibition of nasal carbonic anhydrase affects the CO2 detection threshold in rats.

  Chemical senses 20070301

• Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy.

  The Journal of physiology 20070215

• Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides.

  Bioorganic & medicinal chemistry letters 20070215

• Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.

  Journal of medicinal chemistry 20070125

• The development of topically acting carbonic anhydrase inhibitors as anti-glaucoma agents.

  Current topics in medicinal chemistry 20070101

• Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.

  Journal of medicinal chemistry 20061130

• A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by 'click-tailing'.

  Journal of medicinal chemistry 20061102

• Inhibition profiling of human carbonic anhydrase II by high-throughput screening of structurally diverse, biologically active compounds.

  Journal of biomolecular screening 20061001

• Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.

  Journal of medicinal chemistry 20060907

• Expression, purification, kinetic, and structural characterization of an alpha-class carbonic anhydrase from Aedes aegypti (AaCA1).

  Biochimica et biophysica acta 20060801

• The carbonic anhydrase inhibitors methazolamide and acetazolamide have different effects on the hypoxic ventilatory response in the anaesthetized cat.

  The Journal of physiology 20060715

• Degradation and effects of the potential mosquito larvicides methazolamide and acetazolamide in sheepshead minnow (Cyprinodon variegatus).

  Ecotoxicology and environmental safety 20060701

• Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum.

  Gastroenterology 20060701

• Epithelial carbonic anhydrases facilitate PCO2 and pH regulation in rat duodenal mucosa.

  The Journal of physiology 20060615

• Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa.

  American journal of ophthalmology 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.

  Bioorganic & medicinal chemistry letters 20060415

• Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.

  Journal of medicinal chemistry 20060323

• Mirtazapine in the treatment of essential tremor: an open-label, observer-blind study.

  Neuropsychiatric disease and treatment 20060301

• Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib.

  Bioorganic & medicinal chemistry letters 20060115

• Carbonic anhydrase inhibitors ameliorate the symptoms of hypokalaemic periodic paralysis in rats by opening the muscular Ca2+-activated-K+ channels.

  Neuromuscular disorders : NMD 20060101

• [Diuretic therapy in heart failure].

  Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20060101

• Effects of low-dose methazolamide on the control of breathing in cats.

  Advances in experimental medicine and biology 20060101

• Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.

  Journal of medicinal chemistry 20051201

• Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.

  Bioorganic & medicinal chemistry letters 20051101

• Functional interaction of carbonic anhydrase and chloride/bicarbonate exchange in human platelets.

  Platelets 20051101

• Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.

  Bioorganic & medicinal chemistry letters 20050901

• Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.

  Bioorganic & medicinal chemistry letters 20050901

• Carbonic anhydrase in the adult mosquito midgut.

  The Journal of experimental biology 20050901

• Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.

  Journal of medicinal chemistry 20050728

• Rat adrenal chromaffin cells are neonatal CO2 sensors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050713

• Stimulation of renal sulfate secretion by metabolic acidosis requires Na+/H+ exchange induction and carbonic anhydrase.

  American journal of physiology. Renal physiology 20050701

• Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.

  Bioorganic & medicinal chemistry letters 20050615

• Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.

  Bioorganic & medicinal chemistry letters 20050615

• Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.

  Bioorganic & medicinal chemistry letters 20050502

• Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.

  Bioorganic & medicinal chemistry letters 20050502

• Proton-mediated feedback inhibition of presynaptic calcium channels at the cone photoreceptor synapse.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050420

• Measuring drug concentrations using pulsatile microdialysis: theory and method development in vitro.

  International journal of pharmaceutics 20050411

• HCO3- secretion in the esophageal submucosal glands.

  American journal of physiology. Gastrointestinal and liver physiology 20050401

• Mechanism of augmented duodenal HCO(3)(-) secretion after elevation of luminal CO(2).

  American journal of physiology. Gastrointestinal and liver physiology 20050301

• Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?

  Bioorganic & medicinal chemistry letters 20050215

• Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.

  Bioorganic & medicinal chemistry letters 20050215

• Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.

  Bioorganic & medicinal chemistry letters 20050215

• Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.

  Bioorganic & medicinal chemistry letters 20050201

• Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.

  Bioorganic & medicinal chemistry letters 20050117

• Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa.

  BMC cancer 20050101

• Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.

  Bioorganic & medicinal chemistry letters 20041220

• Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.

  Bioorganic & medicinal chemistry letters 20041206

• Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties.

  Bioorganic & medicinal chemistry letters 20041206

• Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.

  Bioorganic & medicinal chemistry letters 20041101

• Theoretical study of gas-phase acidity, pKa, lipophilicity, and solubility of some biologically active sulfonamides.

  Bioorganic & medicinal chemistry 20041015

• Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library.

  Journal of medicinal chemistry 20041007

• Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.

  Bioorganic & medicinal chemistry letters 20040716

• Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.

  Bioorganic & medicinal chemistry letters 20040621

• Low-dose PGE2 mimics the duodenal secretory response to luminal acid in mice.

  American journal of physiology. Gastrointestinal and liver physiology 20040601

• Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor.

  Journal of enzyme inhibition and medicinal chemistry 20040601

• Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.

  Journal of medicinal chemistry 20040520

• Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity.

  Bioorganic & medicinal chemistry 20040515

• Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.

  Bioorganic & medicinal chemistry letters 20040503

• Acid-base effects on intestinal Cl- absorption and vesicular trafficking.

  American journal of physiology. Cell physiology 20040501

• Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.

  Journal of medicinal chemistry 20040422

• Carbonic anhydrase inhibitors are specific openers of skeletal muscle BK channel of K+-deficient rats.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040401

• Interactions of human organic anion transporters with diuretics.

  The Journal of pharmacology and experimental therapeutics 20040301

• Alkalization of larval mosquito midgut and the role of carbonic anhydrase in different species of mosquitoes.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20040301

• Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.

  Journal of medicinal chemistry 20040226

• Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.

  Bioorganic & medicinal chemistry letters 20040223

• Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.

  Journal of medicinal chemistry 20040129

• Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.

  Bioorganic & medicinal chemistry letters 20040119

• Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.

  Bioorganic & medicinal chemistry letters 20040105

• Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.

  Bioorganic & medicinal chemistry letters 20040105

• NHE3 inhibition activates duodenal bicarbonate secretion in the rat.

  American journal of physiology. Gastrointestinal and liver physiology 20040101

• Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.

  Journal of medicinal chemistry 20031204

• Cortisol alters carbonic anhydrase-mediated renal sulfate secretion.

  American journal of physiology. Regulatory, integrative and comparative physiology 20031201

• Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.

  Bioorganic & medicinal chemistry letters 20030901

• Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the perfluorobenzoyl analogue of methazolamide. Implications for the drug design of fluorinated inhibitors.

  Journal of enzyme inhibition and medicinal chemistry 20030801

• Focal CO2/H+ alters phrenic motor output response to chemical stimulation of cat pre-Botzinger complex in vivo.

  Journal of applied physiology (Bethesda, Md. : 1985) 20030601

• Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.

  Journal of medicinal chemistry 20030522

• Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.

  Journal of medicinal chemistry 20030522

• Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.

  Bioorganic & medicinal chemistry letters 20030324

• Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.

  Bioorganic & medicinal chemistry letters 20030310

• Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.

  Bioorganic & medicinal chemistry letters 20030310

• Effects of oral administration of methazolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs.

  American journal of veterinary research 20030201

• Benefits and risks of pharmacological treatments for essential tremor.

  Drug safety 20030101

• Inhibition of aquaporin-mediated CO2 diffusion and voltage-gated H+ channels by zinc does not alter rabbit lung CO2 and NO excretion.

  Clinical science (London, England : 1979) 20021201

• Forskolin-induced clearance of the fluorescent dye sulforhodamine from rat parotid intralobular duct lumen: visualization of the secretory function under a confocal laser scanning microscope.

  The Journal of membrane biology 20021201

• Non-catalytic role of carbonic anhydrase in rat intestinal absorption.

  Biochimica et biophysica acta 20021114

• Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays.

  Physiological genomics 20021029

• Carbachol-induced fluid movement through methazolamide-sensitive bicarbonate production in rat parotid intralobular ducts: quantitative analysis of fluorescence images using fluorescent dye sulforhodamine under a confocal laser scanning microscope.

  European journal of cell biology 20020901

• Management of essential tremor.

  Current neurology and neuroscience reports 20020701

• Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.

  Bioorganic & medicinal chemistry letters 20020617

• Effects of anion and cation inhibitors and carbonic anhydrase inhibitors upon the activity of the gypsy moth (Lepidoptera: Lymantriidae) nucleo-polyhedrovirus.

  Journal of economic entomology 20020401

• Simulation of the pharmacokinetic profile of methazolamide in blood: effect of erythrocyte carbonic anhydrase binding on drug disposition.

  Pharmaceutical research 20020401

• Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.

  Journal of medicinal chemistry 20020328

• Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.

  Journal of medicinal chemistry 20020117

• Effects of carbonic anhydrase inhibition on the responsiveness of laryngeal receptors in cats to CO2.

  Experimental physiology 20010901

• Increased CO(2) stimulates K/Rb reabsorption mediated by H-K-ATPase in CCD of potassium-restricted rabbit.

  American journal of physiology. Renal physiology 20010801

• Biochemical, histological, and inhibitor studies of membrane carbonic anhydrase in frog gastric acid secretion.

  American journal of physiology. Gastrointestinal and liver physiology 20010701

• Gramicidin-perforated patch analysis on HCO3- secretion through a forskolin-activated anion channel in rat parotid intralobular duct cells.

  The Journal of membrane biology 20010301

• Changes in intraocular pressure associated with topical dorzolamide and oral methazolamide in glaucomatous dogs.

  Veterinary ophthalmology 20010301

• Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.

  Bioorganic & medicinal chemistry letters 20010226

• Cysteine conjugate of methazolamide is metabolized by beta-lyase.

  Journal of pharmaceutical sciences 20010201

• In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics.

  Journal of pharmacokinetics and biopharmaceutics 19990201

• Stevens-Johnson syndrome induced by methazolamide treatment.

  Archives of ophthalmology (Chicago, Ill. : 1960) 19970401

• Methazolamide-induced delirium.

  Pharmacotherapy 19970101

• Colour vision and side-effects during treatment with methazolamide.

  Eye (London, England) 19950101

• Treatment of essential tremor with methazolamide.

  Mayo Clinic proceedings 19911001

• Calcium metabolism in acidotic patients induced by carbonic anhydrase inhibitors: responses to citrate.

  The Journal of urology 19910501

• Organic impotence associated with carbonic anhydrase inhibitor therapy for glaucoma.

  Annals of ophthalmology 19870201

• Methazolamide and acetazolamide in acute mountain sickness.

  Aviation, space, and environmental medicine 19830701

• Methazolamide-induced hepatitis and pure RBC aplasia.

  Archives of internal medicine 19810801

• Blood dyscrasias in patients using methazolamide (neptazane) for glaucoma.

  Ophthalmology 19800401

• Aplastic anemia and agranulocytosis in patients using methazolamide for glaucoma.

  JAMA 19790629

• Nonfatal methazolamide-induced aplastic anemia.

  American journal of ophthalmology 19780701

• Urinary calculus during methazolamide therapy.

  American journal of ophthalmology 19760501

• Urinary calculi with methazolamide therapy.

  Documenta ophthalmologica. Advances in ophthalmology 19730221

• Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors.

  The British journal of ophthalmology 19680801