55837-20-2 | Halofuginone

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$16.00	$11.00
100mg	95%	in stock	$155.00	$108.00
250mg	95%	in stock	$299.00	$209.00
1g	95%	in stock	$805.00	$563.00

Description

• Catalog Number: AB51886
• Chemical Name: Halofuginone
• CAS Number: 55837-20-2
• Molecular Formula: C16H17BrClN3O3
• Molecular Weight: 414.6815
• MDL Number: MFCD09834143
• SMILES: O=C(Cn1cnc2c(c1=O)cc(c(c2)Br)Cl)C[C@H]1NCCC[C@@H]1O

Computed Properties

• Complexity: 533
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 24
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 4
• XLogP3: 1.4

Literature

• Inhibition of matrix metalloproteinase-2 by halofuginone is mediated by the Egr1 transcription factor.

  Anti-cancer drugs 20121101

• Halofuginone prevents estrogen-deficient osteoporosis in mice.

  Journal of cellular biochemistry 20121001

• Validation of the aging hen (Gallus gallus domesticus) as an animal model for uterine leiomyomas.

  Biology of reproduction 20121001

• Halofugine prevents cutaneous graft versus host disease by suppression of Th17 differentiation.

  Hematology (Amsterdam, Netherlands) 20120901

• Anticoccidial effect of halofuginone hydrobromide against Eimeria tenella with associated histology.

  Parasitology research 20120801

• Halofuginone inhibits multiple myeloma growth in vitro and in vivo and enhances cytotoxicity of conventional and novel agents.

  British journal of haematology 20120601

• TH17 cells are critical for skin-specific pathological injury in acute graft-versus-host disease.

  Transplantation proceedings 20120601

• Local inhibition of angiogenesis by halofuginone coated silicone materials.

  Journal of materials science. Materials in medicine 20120501

• Characterization of Plasmodium liver stage inhibition by halofuginone.

  ChemMedChem 20120501

• Reduction of burn scar formation by halofuginone-eluting silicone gel sheets: a controlled study on nude mice.

  Annals of plastic surgery 20120301

• Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice.

  Science translational medicine 20120125

• Th17 response and inflammatory autoimmune diseases.

  International journal of inflammation 20120101

• Halofuginone down-regulates Smad3 expression and inhibits the TGFbeta-induced expression of fibrotic markers in human corneal fibroblasts.

  Molecular vision 20120101

• Altered tryptophan metabolism as a paradigm for good and bad aspects of immune privilege in chronic inflammatory diseases.

  Frontiers in immunology 20120101

• The immune diet: meeting the metabolic demands of lymphocyte activation.

  F1000 biology reports 20120101

• Involvement of host stroma cells and tissue fibrosis in pancreatic tumor development in transgenic mice.

  PloS one 20120101

• Determination of eleven coccidiostats in animal feed by liquid chromatography-tandem mass spectrometry at cross contamination levels.

  Analytica chimica acta 20110826

• Development and validation of a multi-residue liquid chromatography-tandem mass spectrometry confirmatory method for eleven coccidiostats in eggs.

  Analytica chimica acta 20110826

• [An absence of donor TH17 differentiation ameliorates dermal tissue damage].

  Zhonghua yi xue za zhi 20110712

• Efficacy of halofuginone lactate in the prevention of cryptosporidiosis in dairy calves.

  The Veterinary record 20110514

• [The role of Th17 cells in early onset of mice acute graft versus host disease].

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20110501

• Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.

  PLoS genetics 20110401

• Light-chain shuffling from an antigen-biased phage pool allows 185-fold improvement of an anti-halofuginone single-chain variable fragment.

  Analytical biochemistry 20110301

• Is there any synergic effect for coadministration of mitomycin C and halofuginone on the skin wound healing?

  American journal of otolaryngology 20110101

• Phase II AIDS Malignancy Consortium trial of topical halofuginone in AIDS-related Kaposi sarcoma.

  Journal of acquired immune deficiency syndromes (1999) 20110101

• Halofuginone and muscular dystrophy.

  Histology and histopathology 20110101

• Halofuginone-coated urethral catheters prevent periurethral spongiofibrosis in a rat model of urethral injury.

  Journal of endourology 20110101

• Identification of Baicalin as an immunoregulatory compound by controlling T(H)17 cell differentiation.

  PloS one 20110101

• How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?

  Malaria journal 20110101

• Natural products as starting points for future anti-malarial therapies: going back to our roots?

  Malaria journal 20110101

• The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy.

  PloS one 20110101

• Illthrift in suckling lambs secondary to umbilical infections and possible implication of cryptosporidiosis as a risk factor.

  Veterinary medicine international 20110101

• Aberrant repair and fibrosis development in skeletal muscle.

  Skeletal muscle 20110101

• Th17 cells and IL-17 in protective immunity to vaginal candidiasis.

  PloS one 20110101

• Calf health from birth to weaning. II. Management of diarrhoea in pre-weaned calves.

  Irish veterinary journal 20110101

• Probiotics for the control of parasites: an overview.

  Journal of parasitology research 20110101

• Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells.

  BMC research notes 20110101

• Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway.

  PloS one 20110101

• Efficacy of topical halofuginone in myringotomy patency.

  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20101101

• Pharmacokinetic and tissue distribution of doxycycline in broiler chickens pretreated with either: diclazuril or halofuginone.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20101101

• Inhibition of pancreatic stellate cell activation by halofuginone prevents pancreatic xenograft tumor development.

  Pancreas 20101001

• The effects of methylprednisolone and halofuginone on preventing esophageal and hypopharyngeal fibrosis in delivered radiotherapy.

  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20100901

• Is feline acquired reactive perforating collagenosis a wound healing defect? Treatment with topical betamethasone and halofuginone appears beneficial.

  Veterinary dermatology 20100801

• Fibrosis inhibition and muscle histopathology improvement in laminin-alpha2-deficient mice.

  Muscle & nerve 20100801

• Surface modification of silicone breast implants by binding the antifibrotic drug halofuginone reduces capsular fibrosis.

  Plastic and reconstructive surgery 20100701

• Innovative therapies for systemic sclerosis.

  Current opinion in rheumatology 20100501

• Halofuginone inhibits Smad3 phosphorylation via the PI3K/Akt and MAPK/ERK pathways in muscle cells: effect on myotube fusion.

  Experimental cell research 20100401

• Radioprotectors and mitigators of radiation-induced normal tissue injury.

  The oncologist 20100401

• The antifibrotic drug halofuginone inhibits proliferation and collagen production by human leiomyoma and myometrial smooth muscle cells.

  Fertility and sterility 20100301

• Halofuginone, a specific inhibitor of collagen type 1 synthesis, ameliorates oxidant colonic damage in rats with experimental colitis.

  Digestive diseases and sciences 20100301

• Halofuginone enhances the radiation sensitivity of human tumor cell lines.

  Cancer letters 20100301

• Dihydroxylation of vinyl sulfones: stereoselective synthesis of (+)- and (-)-febrifugine and halofuginone.

  The Journal of organic chemistry 20100115

• Halofuginone- and chitosan-coated amnion membranes demonstrate improved abdominal adhesion prevention.

  TheScientificWorldJournal 20100101

• Oesophageal foreign bodies in dogs: factors affecting success of endoscopic retrieval.

  Irish veterinary journal 20100101

• Validation of a multi-residue liquid chromatography-tandem mass spectrometry confirmatory method for 10 anticoccidials in eggs according to Commission Decision 2002/657/EC.

  Journal of chromatography. A 20091113

• Multi-residue confirmatory method for the determination of twelve coccidiostats in chicken liver using liquid chromatography tandem mass spectrometry.

  Journal of chromatography. A 20091113

• Systematic review and meta-analyses of the effects of halofuginone against calf cryptosporidiosis.

  Preventive veterinary medicine 20091001

• Halofuginone mediated protection against radiation-induced leg contracture.

  International journal of oncology 20090801

• Combination of cell culture and quantitative PCR for screening of drugs against Cryptosporidium parvum.

  Veterinary parasitology 20090610

• Immunology. Amino acid addiction.

  Science (New York, N.Y.) 20090605

• Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response.

  Science (New York, N.Y.) 20090605

• Recent advances in the treatment of systemic sclerosis.

  Clinical reviews in allergy & immunology 20090601

• Inhibition of transforming growth factor beta signaling by halofuginone as a modality for pancreas fibrosis prevention.

  Pancreas 20090501

• Effectiveness of topically applied halofuginone in management of subglottic stenosis in rats.

  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20090501

• Synthesis and comparison of antimalarial activity of febrifugine derivatives including halofuginone.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20090501

• Treatment of calf diarrhea: antimicrobial and ancillary treatments.

  The Veterinary clinics of North America. Food animal practice 20090301

• Halofuginone prevents extracellular matrix deposition in diabetic nephropathy.

  Biochemical and biophysical research communications 20090206

• Wound-healing modulation in upper airway stenosis-Myths and facts.

  Head & neck 20090101

• Anti-angiogenic effects of pterogynidine alkaloid isolated from Alchornea glandulosa.

  BMC complementary and alternative medicine 20090101

• Halofuginone has a beneficial effect on gentamicin-induced acute nephrotoxicity in rats.

  Drug and chemical toxicology 20090101

• Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis state of the art.

  Fibrogenesis & tissue repair 20090101

• Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy.

  Hepatology international 20081201

• Prevention of muscle fibrosis and improvement in muscle performance in the mdx mouse by halofuginone.

  Neuromuscular disorders : NMD 20081101

• An outbreak of cryptosporidiosis in a collection of Stone curlews (Burhinus oedicnemus) in Dubai.

  Avian pathology : journal of the W.V.P.A 20081001

• Myofibroblasts in pulmonary and brain metastases of alveolar soft-part sarcoma: a novel target for treatment?

  Neoplasia (New York, N.Y.) 20080901

• The effect of halofuginone, a specific inhibitor of collagen type 1 synthesis, in the prevention of pancreatic fibrosis in an experimental model of severe hyperstimulation and obstruction pancreatitis.

  The Journal of surgical research 20080701

• The preventive effect of halofuginone on posterior glottic stenosis in a rabbit model.

  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20080701

• Halofuginone upregulates the expression of heparanase in thioacetamide-induced liver fibrosis in rats.

  Laboratory investigation; a journal of technical methods and pathology 20080601

• Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone.

  American journal of physiology. Heart and circulatory physiology 20080401

• Focusing on fibrosis: halofuginone-induced functional improvement in the mdx mouse model of Duchenne muscular dystrophy.

  American journal of physiology. Heart and circulatory physiology 20080401

• Type I collagen expression contributes to angiogenesis and the development of deeply invasive cutaneous melanoma.

  International journal of cancer 20080301

• NF-kappa B: a new player in angiostatic therapy.

  Angiogenesis 20080301

• The liver pharmacological and xenobiotic gene response repertoire.

  Molecular systems biology 20080101

• Effect of halofuginone lactate on treatment and prevention of lamb cryptosporidiosis: an extensive field trial.

  Journal of veterinary pharmacology and therapeutics 20071201

• Involvement of ERK signaling in halofuginone-driven inhibition of fibroblast ability to contract collagen lattices.

  European journal of pharmacology 20071114

• (2R,3S)-(+)- and (2S,3R)-(-)-Halofuginone lactate: synthesis, absolute configuration, and activity against Cryptosporidium parvum.

  Bioorganic & medicinal chemistry letters 20070801

• Development and validation of a cell culture based assay for in vitro assessment of anticryptosporidial compounds.

  Parasitology research 20070601

• Gene expression during chemically induced liver fibrosis: effect of halofuginone on TGF-beta signaling.

  Cell and tissue research 20070401

• Evaluation of endotoxaemia in the prognosis and treatment of scouring merino lambs.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20070301

• Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effect.

  Molecular cancer therapeutics 20070201

• Effects of halofuginone on fibrosis formation secondary to experimentally induced subglottic trauma.

  The Laryngoscope 20070201

• Halofuginone reduces the occurrence of renal fibrosis in 5/6 nephrectomized rats.

  The Israel Medical Association journal : IMAJ 20070101

• Potential therapeutical effects of topical halofuginone hydrobromide in keloid management.

  Medical hypotheses 20070101

• Effect of halofuginone, a collagen alpha1(I) inhibitor, on wound healing in normal and irradiated skin: implication for hematopoietic stem cell transplantation.

  Acta haematologica 20070101

• Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options.

  Comparative hepatology 20070101

• Field study of the efficacy of halofuginone and decoquinate in the treatment of cryptosporidiosis in veal calves.

  The Veterinary record 20061111

• Hydrodynamics based transfection in normal and fibrotic rats.

  World journal of gastroenterology 20061014

• Halofuginone inhibits NF-kappaB and p38 MAPK in activated T cells.

  Journal of leukocyte biology 20060801

• Phase I and pharmacokinetic study of halofuginone, an oral quinazolinone derivative in patients with advanced solid tumours.

  European journal of cancer (Oxford, England : 1990) 20060801

• Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB.

  The Journal of biological chemistry 20060602

• Involvement of the tyrosine phosphatase early gene of liver regeneration (PRL-1) in cell cycle and in liver regeneration and fibrosis effect of halofuginone.

  Cell and tissue research 20060601

• Halofuginone prevents subglottic stenosis in a canine model.

  The Annals of otology, rhinology, and laryngology 20060501

• Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition.

  Neoplasia (New York, N.Y.) 20060401

• Halofuginone inhibits tumor growth in the polyoma middle T antigen mouse via a thrombospondin-1 independent mechanism.

  Cancer biology & therapy 20060201

• Inhibition of rat renal fibroblast proliferation by halofuginone.

  Nephron. Experimental nephrology 20060101

• Drug-eluting stent: a review and update.

  Vascular health and risk management 20051201

• Incidence of residues of nine anticoccidials in eggs.

  Food additives and contaminants 20051101

• Inhibition of Wilms tumor xenograft progression by halofuginone is accompanied by activation of WT-1 gene expression.

  The Journal of urology 20051001

• Deposition and depletion of five anticoccidials in eggs.

  Journal of agricultural and food chemistry 20050907

• Prevention of esophageal strictures in a caustic burn model using halofuginone, an inhibitor of collagen type I synthesis.

  The Laryngoscope 20050901

• Halofuginone inhibits collagen deposition in fibrous capsules around implants.

  Annals of plastic surgery 20050301

• Screening for the coccidiostats halofuginone and nicarbazin in egg and chicken muscle: development of an ELISA.

  Food additives and contaminants 20050201

• Residue analysis for halofuginone in sturgeon muscle by immunoaffinity cleanup and liquid chromatography.

  Journal of AOAC International 20050101

• Efficient and sensitive detection of residues of nine coccidiostats in egg and muscle by liquid chromatography-electrospray tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225

• Examination of antimicrobial activity of selected non-antibiotic drugs.

  Acta poloniae pharmaceutica 20041201

• Animal models of systemic sclerosis: insights into systemic sclerosis pathogenesis and potential therapeutic approaches.

  Current opinion in rheumatology 20041101

• Liquid chromatography-electrospray tandem mass spectrometric assay suitable for quantitation of halofuginone in plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041015

• Halofuginone can worsen liver fibrosis in bile duct obstructed rats.

  Liver international : official journal of the International Association for the Study of the Liver 20041001

• Halofuginone inhibits angiogenesis and growth in implanted metastatic rat brain tumor model--an MRI study.

  Neoplasia (New York, N.Y.) 20040901

• Suppression of hepatocellular carcinoma growth in mice by the alkaloid coccidiostat halofuginone.

  European journal of cancer (Oxford, England : 1990) 20040601

• Ureteral replacement using small-intestinal submucosa and a collagen inhibitor in a porcine model.

  Journal of endourology 20040601

• Potential nonhormonal therapeutics for medical treatment of leiomyomas.

  Seminars in reproductive medicine 20040501

• Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.

  The Journal of biological chemistry 20040409

• Smad3 as a mediator of the fibrotic response.

  International journal of experimental pathology 20040401

• Halofuginone, an inhibitor of collagen synthesis by rat stellate cells, stimulates insulin-like growth factor binding protein-1 synthesis by hepatocytes.

  Journal of hepatology 20040201

• The effect of halofuginone, a specific inhibitor of collagen type 1 synthesis, in the prevention of esophageal strictures related to caustic injury.

  American journal of surgery 20040201

• Determination of halofuginone in eggs by liquid chromatography/tandem mass spectrometry after cleanup with immunoaffinity chromatography.

  Rapid communications in mass spectrometry : RCM 20040101

• Halofuginone inhibits serum-stimulated pericardial tissue retraction in vitro.

  Tissue engineering 20040101

• The use of halofuginone in limiting urethral stricture formation and recurrence: an experimental study in rabbits.

  The Journal of urology 20031101

• Treatment with halofuginone results in marked growth inhibition of a von Hippel-Lindau pheochromocytoma in vivo.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20030901

• Resistance to anticoccidial drugs of Dutch avian Eimeria spp. field isolates originating from 1996, 1999 and 2001.

  Avian pathology : journal of the W.V.P.A 20030801

• Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma.

  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20030701

• Development and validation of a method for the confirmation of halofuginone in chicken liver and eggs using electrospray tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030505

• The production and characterisation of an antibody to detect the coccidiostat toltrazuril and its metabolite ponazuril.

  The Analyst 20030501

• A medical compound derived from herbs.

  Science (New York, N.Y.) 20030328

• Prevalence and control of bovine cryptosporidiosis in German dairy herds.

  Veterinary parasitology 20030325

• Hepatitis C and liver fibrosis.

  Cell death and differentiation 20030101

• Hepatic fibrosis: from bench to bedside.

  Journal of gastroenterology and hepatology 20021201

• Halofuginone inhibition of COL1A2 promoter activity via a c-Jun-dependent mechanism.

  Arthritis and rheumatism 20021001

• Halofuginone, a collagen type I inhibitor improves liver regeneration in cirrhotic rats.

  Journal of hepatology 20020901

• Halofuginone does not reduce fibrosis in bleomycin-induced lung injury.

  Life sciences 20020823

• Effect of halofuginone on the development of tight skin (TSK) syndrome.

  Autoimmunity 20020701

• Angiogenesis in bladder cancer--prognostic marker and target for future therapy.

  Surgical oncology 20020601

• The production and characterisation of dinitrocarbanilide antibodies raised using antigen mimics.

  Journal of immunological methods 20020601

• Growth inhibition of prostate cancer xenografts by halofuginone.

  The Prostate 20020501

• Analysis of the effect of halofuginone on bleomycin-induced scleroderma.

  Rheumatology (Oxford, England) 20020501

• Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts.

  The Journal of investigative dermatology 20020301

• Inhibition of anastomotic intimal hyperplasia by a synthetic nonsulphated heparin-mimicking compound.

  Experimental and clinical cardiology 20020101

• Reduction in dermal fibrosis in the tight-skin (Tsk) mouse after local application of halofuginone.

  Biochemical pharmacology 20011101

• Pharmacokinetics and tissue distribution of halofuginone (NSC 713205) in CD2F1 mice and Fischer 344 rats.

  Cancer chemotherapy and pharmacology 20011101

• Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats.

  Hepatology (Baltimore, Md.) 20010201

• Novel therapy in the treatment of scleroderma.

  Expert opinion on investigational drugs 20010101

• Determination of halofuginone and amprolium in chicken muscle and egg by liquid chromatography.

  Journal of AOAC International 20010101

• Halofuginone: a potent inhibitor of critical steps in angiogenesis progression.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20001201

• The activity of halofuginone in immunosuppressed rats infected with Cryptosporidium parvum.

  The Journal of antimicrobial chemotherapy 19950301