56-47-3 | Pregn-4-ene-3,20-dione, 21-(acetyloxy)-

Packsize	Purity	Availability	Price	Discounted Price
1g	≥95%	in stock	$57.00	$40.00
5g	≥95%	in stock	$222.00	$155.00
10g	≥95%	in stock	$413.00	$289.00
25g	≥95%	in stock	$821.00	$575.00

Description

• Catalog Number: AI52559
• Chemical Name: Pregn-4-ene-3,20-dione, 21-(acetyloxy)-
• CAS Number: 56-47-3
• Molecular Formula: C23H32O4
• Molecular Weight: 372.4978
• MDL Number: MFCD00003660
• SMILES: CC(=O)OCC(=O)[C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=CC(=O)CC[C@]12C

Computed Properties

• Complexity: 707
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 6
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• XLogP3: 3.1

Literature

• Genetic and Pharmacologic Inhibition of the Chemokine Receptor CXCR2 Prevents Experimental Hypertension and Vascular Dysfunction.

  Circulation 20161101

• Treatment with heme arginate alleviates adipose tissue inflammation and improves insulin sensitivity and glucose metabolism in a rat model of Human primary aldosteronism.

  Free radical biology & medicine 20121215

• Implication of CD38 gene in podocyte epithelial-to-mesenchymal transition and glomerular sclerosis.

  Journal of cellular and molecular medicine 20120801

• Mice lacking macrophage 12/15-lipoxygenase are resistant to experimental hypertension.

  American journal of physiology. Heart and circulatory physiology 20120601

• A custom rat and baboon hypertension gene array to compare experimental models.

  Experimental biology and medicine (Maywood, N.J.) 20120101

• Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists.

  Journal of medicinal chemistry 20111222

• Relative contributions of mitochondria and NADPH oxidase to deoxycorticosterone acetate-salt hypertension in mice.

  Kidney international 20110701

• Heme arginate suppresses cardiac lesions and hypertrophy in deoxycorticosterone acetate-salt hypertension.

  Experimental biology and medicine (Maywood, N.J.) 20090701

• Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a.

  Hypertension (Dallas, Tex. : 1979) 20080701

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Search of chemical scaffolds for novel antituberculosis agents.

  Journal of biomolecular screening 20050401

• Heme oxygenase-mediated endothelial dysfunction in DOCA-salt, but not in spontaneously hypertensive, rat arterioles.

  American journal of physiology. Heart and circulatory physiology 20040501

• Effect of chronic treatment of adult spontaneously hypertensive rats with an endothelin receptor antagonist.

  Hypertension (Dallas, Tex. : 1979) 19950401

• Effect of indomethacin on desoxycorticosterone acetate-sodium chloride-induced renal lesions in the pregnant rat and her offspring.

  Developmental pharmacology and therapeutics 19800101