56-54-2 | (S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol

Packsize	Purity	Availability	Price	Discounted Price
10g	>98%	in stock	$23.00	$16.00
25g	>98%	in stock	$43.00	$30.00
500g	98%	in stock	$783.00	$548.00

Description

• Catalog Number: AB46974
• Chemical Name: (S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol
• CAS Number: 56-54-2
• Molecular Formula: C20H24N2O2
• Molecular Weight: 324.4168
• MDL Number: MFCD00135581
• SMILES: C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@H](c1ccnc2c1cc(OC)cc2)O

Computed Properties

• Complexity: 457
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 24
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 2.9

Upstream Synthesis Route

As a professional chemist, I can tell you that (9S)-6'-Methoxycinchonan-9-ol is a valuable compound used in chemical synthesis processes. This compound is particularly useful as a chiral building block in the creation of pharmaceuticals, agrochemicals, and other fine chemicals. Due to its unique structure and stereochemistry, (9S)-6'-Methoxycinchonan-9-ol can serve as a key intermediate in the synthesis of complex molecules with specific chirality requirements. Its presence can impart desired biological activity or enhance the efficiency of certain reactions. In the realm of organic chemistry, this compound plays a crucial role in the construction of asymmetric carbon centers, facilitating the production of enantiopure compounds essential in drug discovery and development. Its application in chemical synthesis highlights its significance as a versatile and indispensable tool for achieving precise molecular arrangements and functionalities.

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  Archives of toxicology 20110801

• Pain management in patients with cancer: focus on opioid analgesics.

  Current pain and headache reports 20110801

• Substrate- and species-dependent inhibition of P-glycoprotein-mediated transport: implications for predicting in vivo drug interactions.

  Journal of pharmaceutical sciences 20110801

• Computerized detection of adverse drug reactions in the medical intensive care unit.

  International journal of medical informatics 20110801

• Human liver enzymes responsible for metabolic elimination of tyramine; a vasopressor agent from daily food.

  Drug metabolism letters 20110801

• Nonlinear pharmacokinetics of oral quinidine and verapamil in healthy subjects: a clinical microdosing study.

  Clinical pharmacology and therapeutics 20110801

• Pre-emptive intrathecal quinidine alleviates spinal nerve ligation-induced peripheral neuropathic pain.

  The Journal of pharmacy and pharmacology 20110801

• Impact of impurities on IC50 values of P450 inhibitors.

  Drug metabolism letters 20110801

• Is antiarrhythmic treatment in the elderly different? a review of the specific changes.

  Drugs & aging 20110801

• Erythematous granuloma annulare.

  Annals of dermatology 20110801

• Metabolism of dl-praeruptorin A in rat liver microsomes using HPLC-electrospray ionization tandem mass spectrometry.

  Archives of pharmacal research 20110801

• Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

  Journal of medicinal chemistry 20110714

• Conformational study of 9-dehydro-9-trifluoromethyl cinchona alkaloids via 19F NMR spectroscopy: emergence of trifluoromethyl moiety as a conformational stabilizer and a probe.

  Journal of the American Chemical Society 20110706

• Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.

  Cardiovascular research 20110701

• Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system.

  Pharmacology & therapeutics 20110701

• Anti-prion activities and drug-like potential of functionalized quinacrine analogs with basic phenyl residues at the 9-amino position.

  European journal of medicinal chemistry 20110701

• Pseudobulbar affect: the spectrum of clinical presentations, etiologies and treatments.

  Expert review of neurotherapeutics 20110701

• Mechanisms for membrane transport of metformin in human intestinal epithelial Caco-2 cells.

  Biopharmaceutics & drug disposition 20110701

• Current concepts in the pharmacotherapy of pseudobulbar affect.

  Drugs 20110618

• Dextromethorphan/quinidine (Nuedexta) for pseudobulbar affect.

  The Medical letter on drugs and therapeutics 20110613

• Rapid quantification of quinine and its major metabolite (3S)-3-hydroxyquinine in diluted urine by UPLC-MS/MS.

  Journal of pharmaceutical and biomedical analysis 20110601

• A refined cytochrome P540 IC₅₀ shift assay for reliably identifying CYP3A time-dependent inhibitors.

  Drug metabolism and disposition: the biological fate of chemicals 20110601

• Founder mutations in the Netherlands: familial idiopathic ventricular fibrillation and DPP6.

  Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 20110601

• SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.

  PLoS neglected tropical diseases 20110601

• Inhibition of human cytochrome P450 3A4 by cholesterol.

  The Journal of biological chemistry 20110527

• Successful use of quinine in the treatment of electrical storm in a child with Brugada syndrome.

  Journal of cardiovascular electrophysiology 20110501

• Influences on the pharmacokinetics of oxycodone: a multicentre cross-sectional study in 439 adult cancer patients.

  European journal of clinical pharmacology 20110501

• Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.

  Toxicology and applied pharmacology 20110501

• Mapping of reentrant spontaneous polymorphic ventricular tachycardia in a Scn5a+/- mouse model.

  American journal of physiology. Heart and circulatory physiology 20110501

• Dextromethorphan/quinidine: in pseudobulbar affect.

  CNS drugs 20110501

• Drug-induced lupus erythematosus: incidence, management and prevention.

  Drug safety 20110501

• The impact of VKORC1-1639 G>A polymorphism on the maintenance dose of oral anticoagulants for thromboembolic prophylaxis in North India: A pilot study.

  Indian journal of human genetics 20110501

• Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.

  Journal of medicinal chemistry 20110414

• Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes.

  Toxicology letters 20110410

• Doxycycline for malaria chemoprophylaxis and treatment: report from the CDC expert meeting on malaria chemoprophylaxis.

  The American journal of tropical medicine and hygiene 20110405

• Malaria in pregnancy: update on emergency management.

  The Journal of emergency medicine 20110401

• Yeast response and tolerance to polyamine toxicity involving the drug : H+ antiporter Qdr3 and the transcription factors Yap1 and Gcn4.

  Microbiology (Reading, England) 20110401

• Benfluorex: the last chapter of drug-induced valvular heart disease?

  European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology 20110401

• Transcriptional activation of the anchoring protein SAP97 by heat shock factor (HSF)-1 stabilizes K(v) 1.5 channels in HL-1 cells.

  British journal of pharmacology 20110401

• Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia.

  Circulation. Arrhythmia and electrophysiology 20110401

• Study of stereoselective interactions of carbamoylated quinine and quinidine with 3,5-dinitrobenzoyl α-amino acids using VCD spectroscopy in the region of C−H stretching vibrations.

  Chirality 20110401

• Identification and induction of cytochrome P450s involved in the metabolism of flavone-8-acetic acid in mice.

  Drug metabolism letters 20110401

• Pruritus ani.

  Journal of the Korean Society of Coloproctology 20110401

• Artesunate: investigational drug for the treatment of severe falciparum malaria in Hawai'i.

  Hawaii medical journal 20110401

• The influence of progesterone alone and in combination with estradiol on ventricular action potential duration and triangulation in response to potassium channel inhibition.

  Journal of cardiovascular electrophysiology 20110301

• Torsades, sex hormones, and ventricular repolarization.

  Journal of cardiovascular electrophysiology 20110301

• A novel mutation in the KCNH2 gene associated with short QT syndrome.

  Journal of molecular and cellular cardiology 20110301

• Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.

  Drug metabolism and disposition: the biological fate of chemicals 20110301

• Structural bases for the different anti-fibrillatory effects of chloroquine and quinidine.

  Cardiovascular research 20110301

• Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity.

  European journal of drug metabolism and pharmacokinetics 20110301

• Complete atrioventricular block-induced Torsade de pointes, manifested by epilepsy.

  The Korean journal of internal medicine 20110301

• Recent developments in the management of patients at risk for sudden cardiac death.

  Postgraduate medicine 20110301

• From toxins targeting ligand gated ion channels to therapeutic molecules.

  Toxins 20110301

• The direct asymmetric vinylogous aldol reaction of furanones with α-ketoesters: access to chiral γ-butenolides and glycerol derivatives.

  Angewandte Chemie (International ed. in English) 20110218

• Electrical storm in Brugada syndrome during pregnancy.

  Pacing and clinical electrophysiology : PACE 20110201

• Coffee, broccoli and spices are strong inducers of electrophile response element-dependent transcription in vitro and in vivo - studies in electrophile response element transgenic mice.

  Molecular nutrition & food research 20110201

• A hybrid process for chiral separation of compound-forming systems.

  Chirality 20110201

• The utility of in vitro data in making accurate predictions of human P-glycoprotein-mediated drug-drug interactions: a case study for AZD5672.

  Drug metabolism and disposition: the biological fate of chemicals 20110201

• Spatial and temporal heterogeneities are localized to the right ventricular outflow tract in a heterozygotic Scn5a mouse model.

  American journal of physiology. Heart and circulatory physiology 20110201

• Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillation.

  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20110201

• Present state and future perspectives of using pluripotent stem cells in toxicology research.

  Archives of toxicology 20110201

• Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis.

  Journal of natural products 20110128

• New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases.

  Journal of medicinal chemistry 20110127

• In vitro biotransformation and investigation of metabolic enzymes possibly responsible for the metabolism of bisdesoxyolaquindox in the liver fractions of rats, chicken, and pigs.

  Toxicology 20110111

• Maternal baicalin treatment increases fetal lung surfactant phospholipids in rats.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Traditional Medicinal Plant Extracts and Natural Products with Activity against Oral Bacteria: Potential Application in the Prevention and Treatment of Oral Diseases.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Antiarrhythmic and antioxidant activity of novel pyrrolidin-2-one derivatives with adrenolytic properties.

  Naunyn-Schmiedeberg's archives of pharmacology 20110101

• A KCR1 variant implicated in susceptibility to the long QT syndrome.

  Journal of molecular and cellular cardiology 20110101

• Organic cation transporter-mediated renal secretion of ipratropium and tiotropium in rats and humans.

  Drug metabolism and disposition: the biological fate of chemicals 20110101

• Delayed conduction and its implications in murine Scn5a(+/-) hearts: independent and interacting effects of genotype, age, and sex.

  Pflugers Archiv : European journal of physiology 20110101

• CYP1A2-mediated biotransformation of cardioactive 2-thienylidene-3,4-methylenedioxybenzoylhydrazine (LASSBio-294) by rat liver microsomes and human recombinant CYP enzymes.

  European journal of medicinal chemistry 20110101

• Regulating the regulators: the post-translational code of class I HDAC1 and HDAC2.

  Journal of biomedicine & biotechnology 20110101

• Impact of sarcoplasmic reticulum calcium release on calcium dynamics and action potential morphology in human atrial myocytes: a computational study.

  PLoS computational biology 20110101

• Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum.

  Malaria journal 20110101

• Role of investigating thrombophilic disorders in young stroke.

  Stroke research and treatment 20110101

• Sex differences in drug disposition.

  Journal of biomedicine & biotechnology 20110101

• Optical coherence tomography findings of quinine poisoning.

  Clinical ophthalmology (Auckland, N.Z.) 20110101

• Parkinsonism caused by adverse drug reactions: a case series.

  Journal of medical case reports 20110101

• A call for using natural compounds in the development of new antimalarial treatments - an introduction.

  Malaria journal 20110101

• Natural products as starting points for future anti-malarial therapies: going back to our roots?

  Malaria journal 20110101

• Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions.

  Malaria journal 20110101

• Identification of platelet refractoriness in oncohematologic patients.

  Clinics (Sao Paulo, Brazil) 20110101

• Paliperidone extended-release: does it have a place in antipsychotic therapy?

  Drug design, development and therapy 20110101

• Atrial fibrillation and the use of oral bisphosphonates.

  Therapeutics and clinical risk management 20110101

• Inhibition of ATP-sensitive K+ channels and L-type Ca2+ channels by amiodarone elicits contradictory effect on insulin secretion in MIN6 cells.

  Journal of pharmacological sciences 20110101

• A study of toxicity and differential gene expression in murine liver following exposure to anti-malarial drugs: amodiaquine and sulphadoxine-pyrimethamine.

  Malaria journal 20110101

• Pharmacokinetics of tolbutamide in acute renal failure induced by glycerol: speculative thoughts and perspectives.

  Drug metabolism and pharmacokinetics 20110101

• Studies of new fused benzazepine as selective dopamine D3 receptor antagonists using 3D-QSAR, molecular docking and molecular dynamics.

  International journal of molecular sciences 20110101

• Fatal Myocarditis in Course of Plasmodium falciparum Infection: Case Report and Review of Cardiac Complications in Malaria.

  Case reports in medicine 20110101

• The stress response factors Yap6, Cin5, Phd1, and Skn7 direct targeting of the conserved co-repressor Tup1-Ssn6 in S. cerevisiae.

  PloS one 20110101

• Monitoring disopyramide, lidocaine, and quinidine by micellar liquid chromatography.

  Journal of AOAC International 20110101

• Overexpression of CYP3A4, but not of CYP2D6, promotes hypoxic response and cell growth of Hep3B cells.

  Drug metabolism and pharmacokinetics 20110101

• Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes.

  Journal of translational medicine 20110101

• Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers.

  Cell communication and signaling : CCS 20110101

• Pharmacological management of atrial fibrillation: one, none, one hundred thousand.

  Cardiology research and practice 20110101

• Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin production.

  PloS one 20110101

• Hypoglycaemia and severe Plasmodium falciparum malaria among pregnant Sudanese women in an area characterized by unstable malaria transmission.

  Parasites & vectors 20110101

• Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome.

  PloS one 20110101

• Vascular endothelial growth factor inhibitor-induced hypertension: basics for primary care providers.

  Cardiology research and practice 20110101

• Biochemical and genetic analysis of butyrylcholinesterase (BChE) in a family, due to prolonged neuromuscular blockade after the use of succinylcholine.

  Genetics and molecular biology 20110101

• Metabolic manipulation in chronic heart failure: study protocol for a randomised controlled trial.

  Trials 20110101

• Polymorphism of Plasmodium falciparum Na(+)/H(+) exchanger is indicative of a low in vitro quinine susceptibility in isolates from Viet Nam.

  Malaria journal 20110101

• Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review.

  Journal of pharmacy & bioallied sciences 20110101

• Update on the optimal use of voriconazole for invasive fungal infections.

  Infection and drug resistance 20110101

• Role of aliskiren in blood pressure control and renoprotection.

  International journal of nephrology and renovascular disease 20110101

• Extra-corporeal life support for near-fatal multi-drug intoxication: a case report.

  Journal of medical case reports 20110101

• Atrial fibrillation (acute onset).

  BMJ clinical evidence 20110101

• Octreotide-induced thrombocytopenia: a case report.

  Journal of medical case reports 20110101

• Effects of quinidine on the action potential duration restitution property in the right ventricular outflow tract in patients with brugada syndrome.

  Circulation journal : official journal of the Japanese Circulation Society 20110101

• Improvement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer.

  International journal of nanomedicine 20110101

• Clinical potential of lurasidone in the management of schizophrenia.

  Therapeutics and clinical risk management 20110101

• Prevention of sudden cardiac death.

  Indian pacing and electrophysiology journal 20110101

• A novel study design for antibiotic trials in acute exacerbations of COPD: MAESTRAL methodology.

  International journal of chronic obstructive pulmonary disease 20110101

• Developing and testing a high-fidelity simulation scenario for an uncommon life-threatening disease: severe malaria.

  Journal of tropical medicine 20110101

• Isoniazid causing drug-induced thrombocytopenia.

  Eplasty 20110101

• Treatment of African children with severe malaria - towards evidence-informed clinical practice using GRADE.

  Malaria journal 20110101

• Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs).

  PloS one 20110101

• Clinical therapeutics in pregnancy.

  Journal of biomedicine & biotechnology 20110101

• Evaluation of CYP450 inhibitory effects and steady-state pharmacokinetics of genistein in combination with cholecalciferol and citrated zinc bisglycinate in postmenopausal women.

  International journal of women's health 20110101

• Battle of oral anticoagulants in the field of atrial fibrillation scrutinized from a clinical practice (the real world) perspective.

  Thrombosis journal 20110101

• Depression in vascular pathologies: the neurologist's point of view.

  Vascular health and risk management 20110101

• Cinchona alkaloids are also produced by an endophytic filamentous fungus living in cinchona plant.

  Chemical & pharmaceutical bulletin 20110101

• Perioperative atrial fibrillation in five patients - role of anxiety.

  Journal of anaesthesiology, clinical pharmacology 20110101

• Frequent Ventricular Premature Contractions under Anaesthesia in Prone Position.

  Journal of anaesthesiology, clinical pharmacology 20110101

• Predictors of atrial fibrillation following coronary artery bypass grafting.

  Clinical Medicine Insights. Cardiology 20110101

• Homocysteine as a risk factor for atherosclerosis: is its conversion to s-adenosyl-L-homocysteine the key to deregulated lipid metabolism?

  Journal of lipids 20110101

• Molecular markers of anti-malarial drug resistance in Lahj Governorate, Yemen: baseline data and implications.

  Malaria journal 20110101

• BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells.

  PloS one 20110101

• On-chip constructive cell-network study (II): on-chip quasi-in vivo cardiac toxicity assay for ventricular tachycardia/fibrillation measurement using ring-shaped closed circuit microelectrode with lined-up cardiomyocyte cell network.

  Journal of nanobiotechnology 20110101

• Treating nausea and vomiting in palliative care: a review.

  Clinical interventions in aging 20110101

• Pharmacogenetic testing affects choice of therapy among women considering tamoxifen treatment.

  Genome medicine 20110101

• Utility of frozen cell lines in medium throughput electrophysiology screening of hERG and NaV1.5 blockade.

  Journal of pharmacological and toxicological methods 20110101

• Na Channel β Subunits: Overachievers of the Ion Channel Family.

  Frontiers in pharmacology 20110101

• Identification of intracellular and plasma membrane calcium channel homologues in pathogenic parasites.

  PloS one 20110101

• Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast.

  BMC biology 20110101

• Fitting the elementary rate constants of the P-gp transporter network in the hMDR1-MDCK confluent cell monolayer using a particle swarm algorithm.

  PloS one 20110101

• Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology.

  PloS one 20110101

• Targeting GIRK Channels for the Development of New Therapeutic Agents.

  Frontiers in pharmacology 20110101

• A patient with mexiletine-related psychosis.

  International journal of general medicine 20110101

• A Primer on Detecting Cirrhosis and Caring for These Patients without Causing Harm.

  International journal of hepatology 20110101

• 'Wait and see' approach to the emergency department cardioversion of acute atrial fibrillation.

  Emergency medicine international 20110101

• Drug allergy.

  Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20110101

• Rapid and green analytical method for the determination of quinoline alkaloids from Cinchona succirubra based on Microwave-Integrated Extraction and Leaching (MIEL) prior to high performance liquid chromatography.

  International journal of molecular sciences 20110101

• Psychosocial implications of tubal ligation in a rural health district: a phenomenological study.

  Reproductive health 20110101

• Pharmacological basis and clinical evidence of dabigatran therapy.

  Journal of hematology & oncology 20110101

• Identification of pyrimethamine- and chloroquine-resistant Plasmodium falciparum in Africa between 1984 and 1998: genotyping of archive blood samples.

  Malaria journal 20110101

• Piperacillin-induced immune hemolysis presenting with tachycardia and cardiac arrest.

  Case reports in medicine 20110101

• Functionally Relevant Residues of Cdr1p: A Multidrug ABC Transporter of Human Pathogenic Candida albicans.

  Journal of amino acids 20110101

• Evaluation of the reinforcing and subjective effects of heroin in combination with dextromethorphan and quinidine.

  Journal of opioid management 20110101

• A single blind comparative clinical study of the effects of chlorpromazine and risperidone on positive and negative symptoms in patients of schizophrenia.

  Indian journal of psychological medicine 20110101

• Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs.

  ISRN pharmaceutics 20110101

• QT Interval and QT Dispersion in Patients Undergoing Hemodialysis: Revisiting the Old Theory.

  Nephron extra 20110101

• A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.

  Journal of medicinal chemistry 20101223

• Highly enantioselective organocatalytic α-amination reactions of aryl oxindoles: developing designer multifunctional alkaloid catalysts.

  Organic letters 20101217

• An electrochemical microfluidic platform for human P450 drug metabolism profiling.

  Analytical chemistry 20101215

• Quinidine thiourea-catalyzed aldol reaction of unactivated ketones: highly enantioselective synthesis of 3-alkyl-3-hydroxyindolin-2-ones.

  Angewandte Chemie (International ed. in English) 20101203

• A predictive ligand-based Bayesian model for human drug-induced liver injury.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women.

  European journal of clinical pharmacology 20101201

• Characterisation of zuclopenthixol metabolism by in vitro and therapeutic drug monitoring studies.

  Acta psychiatrica Scandinavica 20101201

• Cytochrome P450-mediated hepatic metabolism of new fluorescent substrates in cats and dogs.

  Journal of veterinary pharmacology and therapeutics 20101201

• Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.

  Assay and drug development technologies 20101201

• Successful drug development despite adverse preclinical findings part 1: processes to address issues and most important findings.

  Journal of toxicologic pathology 20101201

• Adenosine triphosphate depletion by cyanide results in a Na(+)-dependent Mg(2+) extrusion from liver cells.

  Metabolism: clinical and experimental 20101101

• Dextromethorphan plus ultra low-dose quinidine reduces pseudobulbar affect.

  Annals of neurology 20101101

• Modulation of drug block of the cardiac potassium channel KCNA5 by the drug transporters OCTN1 and MDR1.

  British journal of pharmacology 20101101

• Strong detrimental effect of a minute enantiomeric impurity of a chiral selector on the enantioselectivity factor.

  Angewandte Chemie (International ed. in English) 20101011

• Drug-induced arrhythmia.

  Circulation 20101005

• Regional variations in action potential alternans in isolated murine Scn5a (+/-) hearts during dynamic pacing.

  Acta physiologica (Oxford, England) 20101001

• Increased right ventricular repolarization gradients promote arrhythmogenesis in a murine model of Brugada syndrome.

  Journal of cardiovascular electrophysiology 20101001

• Poly(vinyl alcohol) microspheres with pH- and thermosensitive properties as temperature-controlled drug delivery.

  Acta biomaterialia 20101001

• Interaction between topically and systemically coadministered P-glycoprotein substrates/inhibitors: effect on vitreal kinetics.

  Drug metabolism and disposition: the biological fate of chemicals 20101001

• Atrial arrhythmogenic properties in wild-type and Scn5a+/- murine hearts.

  Experimental physiology 20101001

• Monitoring of troponin release from cardiomyocytes during exposure to toxic substances using surface plasmon resonance biosensing.

  Analytical and bioanalytical chemistry 20101001

• Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase.

  Pharmacogenetics and genomics 20101001

• Ca2+-dependent and Na+-dependent K+ conductances contribute to a slow AHP in thalamic paraventricular nucleus neurons: a novel target for orexin receptors.

  Journal of neurophysiology 20101001

• Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and ABCB1 wild type dogs.

  Journal of veterinary pharmacology and therapeutics 20101001

• Metabolomics-based discovery of diagnostic biomarkers for onchocerciasis.

  PLoS neglected tropical diseases 20101001

• Pharmacological properties and physiological function of a P2X-like current in single proximal tubule cells isolated from frog kidney.

  The Journal of membrane biology 20101001

• Bifunctional thiourea-promoted cascade aza-Michael-Henry-dehydration reactions: asymmetric preparation of 3-nitro-1,2-dihydroquinolines.

  Organic & biomolecular chemistry 20100921

• Discovering drug-drug interactions: a text-mining and reasoning approach based on properties of drug metabolism.

  Bioinformatics (Oxford, England) 20100915

• Uptake of codeine into intestinal epithelial (Caco-2) and brain endothelial (RBE4) cells.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100911

• A phenotypic combination of idiopathic VF and Brugada syndrome.

  Pacing and clinical electrophysiology : PACE 20100901

• In vivo studies of Scn5a+/- mice modeling Brugada syndrome demonstrate both conduction and repolarization abnormalities.

  Journal of electrocardiology 20100901

• Treatment of Irritability in Huntington's Disease.

  Current treatment options in neurology 20100901

• Interaction of gatifloxacin with efflux transporters: a possible mechanism for drug resistance.

  International journal of pharmaceutics 20100816

• Characterization of glutathione conjugates of duloxetine by mass spectrometry and evaluation of in silico approaches to rationalize the site of conjugation for thiophene containing drugs.

  Chemical research in toxicology 20100816

• Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages.

  Biochemical and biophysical research communications 20100806

• Effects of flecainide and quinidine on action potential and ventricular arrhythmogenic properties in Scn3b knockout mice.

  Clinical and experimental pharmacology & physiology 20100801

• Furanocoumarin derivatives in Kampo extract medicines inhibit cytochrome P450 3A4 and P-glycoprotein.

  Drug metabolism and disposition: the biological fate of chemicals 20100801

• Quinidine interaction with Shab K+ channels: pore block and irreversible collapse of the K+ conductance.

  The Journal of physiology 20100801

• Atrial arrhythmogenicity in aged Scn5a+/DeltaKPQ mice modeling long QT type 3 syndrome and its relationship to Na+ channel expression and cardiac conduction.

  Pflugers Archiv : European journal of physiology 20100801

• Evaluation of cytochrome P450 inhibition assays using human liver microsomes by a cassette analysis /LC-MS/MS.

  Drug metabolism letters 20100801

• Rifampicin-induced thrombocytopenia.

  Indian journal of pharmacology 20100801

• Last stop before exit - hepatitis C assembly and release as antiviral drug targets.

  Viruses 20100801

• Development of a drug screening platform based on engineered heart tissue.

  Circulation research 20100709

• The anti-necrosis role of hypoxic preconditioning after acute anoxia is mediated by aldose reductase and sorbitol pathway in PC12 cells.

  Cell stress & chaperones 20100701

• Stereoselective and multiple carrier-mediated transport of cetirizine across Caco-2 cell monolayers with potential drug interaction.

  Chirality 20100701

• Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3.

  Cardiovascular research 20100701

• Examination of the ability of the nasal administration route to confer a brain exposure advantage for three chemical inhibitors of P-glycoprotein.

  Journal of pharmaceutical sciences 20100701

• Successful acute and long-term management of electrical storm in Brugada syndrome using orciprenaline and quinine/quinidine.

  Clinical research in cardiology : official journal of the German Cardiac Society 20100701

• Quantitative prediction of intestinal metabolism in humans from a simplified intestinal availability model and empirical scaling factor.

  Drug metabolism and disposition: the biological fate of chemicals 20100701

• Differential roles of phase I and phase II enzymes in 3,4-methylendioxymethamphetamine-induced cytotoxicity.

  Drug metabolism and disposition: the biological fate of chemicals 20100701

• Effects of K openers on the QT prolongation induced by HERG-blocking drugs in guinea-pigs.

  The Journal of pharmacy and pharmacology 20100701

• Organocatalytic Michael addition of unprotected 3-substituted oxindoles to nitroolefins.

  Organic & biomolecular chemistry 20100628

• Arrhythmic risk biomarkers for the assessment of drug cardiotoxicity: from experiments to computer simulations.

  Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 20100628

• Novel quinolizidinyl derivatives as antiarrhythmic agents: 2. Further investigation.

  Journal of medicinal chemistry 20100624

• Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation.

  Cell metabolism 20100609

• Development and validation of RP-HPLC-fluorescence method for quantitative determination of quinidine, a probe substrate for P-glycoprotein inhibition assay using Caco-2 cell monolayer.

  Biomedical chromatography : BMC 20100601

• High efficacy of disopyramide in the management of ventricular fibrillation storms in a patient with Brugada syndrome.

  Pacing and clinical electrophysiology : PACE 20100601

• Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation.

  Drug metabolism and disposition: the biological fate of chemicals 20100601

• To the editor--Irreplaceable antiarrhythmic medications are disappearing: the case of quinidine.

  Heart rhythm 20100601

• To the editor:--Old drugs never die; they just fade away.

  Heart rhythm 20100601

• To the editor--Market withdrawal of quinidine bisulfate (Kinidin Durules) in 2006.

  Heart rhythm 20100601

• To the editor: response---Irreplaceable antiarrhythmic medications are disappearing: the case of quinidine.

  Heart rhythm 20100601

• Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone.

  The Journal of pharmacology and experimental therapeutics 20100601

• Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans.

  Therapeutic drug monitoring 20100601

• Inline pneumatically assisted atmospheric pressure matrix-assisted laser desorption/ionization ion trap mass spectrometry.

  Journal of mass spectrometry : JMS 20100601

• The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone.

  British journal of pharmacology 20100601

• Genetic polymorphisms and drug interactions modulating CYP2D6 and CYP3A activities have a major effect on oxycodone analgesic efficacy and safety.

  British journal of pharmacology 20100601

• Study on absorption sites of quinidine and methotrexate in rat intestine.

  Die Pharmazie 20100601

• A status report on drug-associated acne and acneiform eruptions.

  Journal of drugs in dermatology : JDD 20100601

• A mathematical model to understand the mechanisms of action of class 1 antiarrhythmic drugs.

  Indian journal of pharmacology 20100601

• Overcoming multidrug resistance in human cancer cells by natural compounds.

  Toxins 20100601

• Targeting SYK kinase-dependent anti-apoptotic resistance pathway in B-lineage acute lymphoblastic leukaemia (ALL) cells with a potent SYK inhibitory pentapeptide mimic.

  British journal of haematology 20100501

• Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum.

  PLoS pathogens 20100501

• Dimeric quinidine-catalyzed enantioselective aminooxygenation of oxindoles: an organocatalytic approach to 3-hydroxyoxindole derivatives.

  Journal of the American Chemical Society 20100428

• Crystal engineering of pharmaceutical Co-crystals: application of methyl paraben as molecular hook.

  Journal of the American Chemical Society 20100414

• Effect of polymer hygroscopicity on the phase behavior of amorphous solid dispersions in the presence of moisture.

  Molecular pharmaceutics 20100405

• Effects of experimental setup on the apparent concentration dependency of active efflux transport in in vitro cell permeation experiments.

  Molecular pharmaceutics 20100405

• Considerations on the use of adjunct red blood cell exchange transfusion in the treatment of severe Plasmodium falciparum malaria.

  Transfusion 20100401

• In vitro assessment of cytochrome P450 inhibition and induction potential of azacitidine.

  Cancer chemotherapy and pharmacology 20100401

• Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model.

  Pharmaceutical research 20100401

• Evaluation of in vivo P-glycoprotein phenotyping probes: a need for validation.

  Clinical pharmacokinetics 20100401

• Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells.

  The European journal of neuroscience 20100401

• AVP-923, a combination of dextromethorphan hydrobromide and quinidine sulfate for the treatment of pseudobulbar affect and neuropathic pain.

  IDrugs : the investigational drugs journal 20100401

• Drug-induced thrombocytopenia for the hospitalist physician with a focus on heparin-induced thrombocytopenia.

  Hospital practice (1995) 20100401

• Pyrazinamide induced thrombocytopenia.

  Indian journal of pharmacology 20100401

• Chiral recognition in cinchona alkaloid protonated dimers: mass spectrometry and UV photodissociation studies.

  The journal of physical chemistry. A 20100311

• HPLC of basic drugs using non-aqueous ionic eluents: evaluation of a 3 mum strong cation-exchange material.

  Biomedical chromatography : BMC 20100301

• Dielectric study of equimolar acetaminophen-aspirin, acetaminophen-quinidine, and benzoic acid-progesterone molecular alloys in the glass and ultraviscous states and their relevance to solubility and stability.

  Journal of pharmaceutical sciences 20100301

• In vitro selection of Plasmodium falciparum drug-resistant parasite lines.

  The Journal of antimicrobial chemotherapy 20100301

• Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes.

  Stem cell research 20100301

• A case of Brugada syndrome presenting with incessant polymorphic ventricular tachycardia.

  Clinical cardiology 20100301

• Model analysis of the concentration-dependent permeability of P-gp substrates.

  Pharmaceutical research 20100301

• Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies.

  Analytical and bioanalytical chemistry 20100301

• A semi-mechanistic model to predict the effects of liver cirrhosis on drug clearance.

  Clinical pharmacokinetics 20100301

• Safety considerations of fluoroquinolones in the elderly: an update.

  Drugs & aging 20100301

• Decoding pathogenesis of slow-channel congenital myasthenic syndromes using recombinant expression and mice models.

  Puerto Rico health sciences journal 20100301

• Pharmacokinetic interactions between ritonavir and quinine in healthy volunteers following concurrent administration.

  British journal of clinical pharmacology 20100301

• A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle.

  Proceedings of the National Academy of Sciences of the United States of America 20100223

• Catalytic asymmetric formation of delta-lactones from unsaturated acyl halides.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20100222

• Chemoreceptor hypersensitivity, sympathetic excitation, and overexpression of ASIC and TASK channels before the onset of hypertension in SHR.

  Circulation research 20100219

• Practical and highly selective sulfur ylide mediated asymmetric epoxidations and aziridinations using an inexpensive, readily available chiral sulfide. Applications to the synthesis of quinine and quinidine.

  Journal of the American Chemical Society 20100217

• Enantiomer separation and indirect chromatographic absolute configuration prediction of chiral pirinixic acid derivatives: Limitations of polysaccharide-type chiral stationary phases in comparison to chiral anion-exchangers.

  Journal of chromatography. A 20100212

• 'Orphan drugs' in cardiology: nadolol and quinidine.

  Journal of cardiovascular medicine (Hagerstown, Md.) 20100201

• Effects of cytochrome P450 inhibitors on the biotransformation of fluorogenic substrates by adult male rat liver microsomes and cDNA-expressed rat cytochrome P450 isoforms.

  Toxicological sciences : an official journal of the Society of Toxicology 20100201

• Inhibition of UV-B induced apoptosis in corneal epithelial cells by potassium channel modulators.

  Experimental eye research 20100201

• If the KI is defined by the free energy of binding to P-glycoprotein, which kinetic parameters define the IC50 for the Madin-Darby canine kidney II cell line overexpressing human multidrug resistance 1 confluent cell monolayer?

  Drug metabolism and disposition: the biological fate of chemicals 20100201

• Synthesis and biological activity of the calcium modulator (R) and (S)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

  Bioorganic & medicinal chemistry letters 20100201

• Trimipraminium maleate.

  Acta crystallographica. Section E, Structure reports online 20100201

• Comparative study of the oxidation of propranolol enantiomers in hepatic and small intestinal microsomes from cynomolgus and marmoset monkeys.

  Chemico-biological interactions 20100105

• Blood-brain barrier transport of naloxone does not involve P-glycoprotein-mediated efflux.

  Journal of pharmaceutical sciences 20100101

• Resonance light scattering study on the interaction between quinidine sulfate and congo red and its analytical application.

  Luminescence : the journal of biological and chemical luminescence 20100101

• Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux.

  Pharmacological research 20100101

• Involvement of OCTN2 in the transport of acetyl-L-carnitine across the inner blood-retinal barrier.

  Investigative ophthalmology & visual science 20100101

• Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine.

  Channels (Austin, Tex.) 20100101

• Effect of metabolic blockade on the psychoactive effects of dextromethorphan.

  Human psychopharmacology 20100101

• Cellular basis for atrial fibrillation in an experimental model of short QT1: implications for a pharmacological approach to therapy.

  Heart rhythm 20100101

• Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay.

  BMC biochemistry 20100101

• Congenital short QT syndrome.

  Indian pacing and electrophysiology journal 20100101

• How the heart can fibrillate: when diversity is a disadvantage.

  Heart rhythm 20100101

• Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study.

  BMJ (Clinical research ed.) 20100101

• The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes.

  Journal of pharmacological and toxicological methods 20100101

• Spontaneous recovery of the injured higher olfactory center in the terrestrial slug limax.

  PloS one 20100101

• Surface engineering of macrophages with nanoparticles to generate a cell-nanoparticle hybrid vehicle for hypoxia-targeted drug delivery.

  International journal of nanomedicine 20100101

• Severe odynophagia in a patient developing after azithromycin intake: a case report.

  Cases journal 20100101

• KCNQ1 K+ channels are involved in lipopolysaccharide-induced apoptosis of distal kidney cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• Inhibition of 2-aminoethoxydiphenyl borate-induced rat atrial ectopic activity by anti-arrhythmic drugs.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• Human and murine embryonic stem cell-derived cardiomyocytes serve together as a valuable model for drug safety screening.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• The risk of performing cardiopulmonary bypass in malaria patients: a small case series.

  Texas Heart Institute journal 20100101

• Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate.

  PloS one 20100101

• Atorvastatin as a potential anti-malarial drug: in vitro synergy in combinational therapy with quinine against Plasmodium falciparum.

  Malaria journal 20100101

• Platelet transfusions: trigger, dose, benefits, and risks.

  F1000 medicine reports 20100101

• New options with dabigatran etexilate in anticoagulant therapy.

  Vascular health and risk management 20100101

• Intravenous artesunate for the treatment of severe malaria.

  The Annals of pharmacotherapy 20100101

• Risk stratification in young patients with channelopathies.

  Indian pacing and electrophysiology journal 20100101

• Proarrhythmia Induced by Propafenone: What is the Mechanism?

  Indian pacing and electrophysiology journal 20100101

• Ventricular tachycardia in pregnant patients.

  Clinical Medicine Insights. Cardiology 20100101

• Emergency therapy of maternal and fetal arrhythmias during pregnancy.

  Journal of emergencies, trauma, and shock 20100101

• Sodium channel molecular conformations and antiarrhythmic drug affinity.

  Trends in cardiovascular medicine 20100101

• Membrane transport mechanisms of quinidine and procainamide in renal LLC-PK1 and intestinal LS180 cells.

  Biological & pharmaceutical bulletin 20100101

• Artemisone effective against murine cerebral malaria.

  Malaria journal 20100101

• Principal component analysis of HPLC retention data and molecular modeling structural parameters of cardiovascular system drugs in view of their pharmacological activity.

  International journal of molecular sciences 20100101

• Dronedarone for the treatment of atrial fibrillation and atrial flutter: approval and efficacy.

  Vascular health and risk management 20100101

• Repetitive compound muscle action potentials in electrophysiological diagnosis of congenital myasthenic syndromes: a case report and review of literature.

  Annals of Indian Academy of Neurology 20100101

• Emerging treatments in the management of schizophrenia - focus on sertindole.

  Drug design, development and therapy 20100101

• Selection and preference for botulinum toxins in the management of photoaging and facial lines: patient and physician considerations.

  Patient preference and adherence 20100101

• Recent advances in the management of chronic stable angina II. Anti-ischemic therapy, options for refractory angina, risk factor reduction, and revascularization.

  Vascular health and risk management 20100101

• Evidence at a glance: error matrix approach for overviewing available evidence.

  BMC medical research methodology 20100101

• Design of the Prevention of Adult Caries Study (PACS): a randomized clinical trial assessing the effect of a chlorhexidine dental coating for the prevention of adult caries.

  BMC oral health 20100101

• Brugada syndrome: Controversies in Risk stratification and Management.

  Indian pacing and electrophysiology journal 20100101

• A review of the mechanisms of ventricular arrhythmia in brugada syndrome.

  Indian pacing and electrophysiology journal 20100101

• Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to acetic acid.

  Microbial cell factories 20100101

• Antiphospholipid syndrome; its implication in cardiovascular diseases: a review.

  Journal of cardiothoracic surgery 20100101

• Effects of anti-malarial drugs on the electrocardiographic QT interval modelled in the isolated perfused guinea pig heart system.

  Malaria journal 20100101

• Development, clinical utility, and place in therapy of posaconazole for prevention and treatment of invasive fungal infections.

  Drug design, development and therapy 20100101

• The persistent sodium current blocker riluzole is antiarrhythmic and anti-ischaemic in a pig model of acute myocardial infarction.

  PloS one 20100101

• On the mechanism of chloroquine resistance in Plasmodium falciparum.

  PloS one 20100101

• Traditional herbal medicine in far-west Nepal: a pharmacological appraisal.

  Journal of ethnobiology and ethnomedicine 20100101

• Anti-malaria drug mefloquine induces motor learning deficits in humans.

  Frontiers in neuroscience 20100101

• Outward Currents Contributing to Inspiratory Burst Termination in preBötzinger Complex Neurons of Neonatal Mice Studied in Vitro.

  Frontiers in neural circuits 20100101

• Do selective serotonin receptor inhibitor antidepressants reduce tamoxifen's effectiveness and increase the risk of death from breast cancer?

  Breast cancer research : BCR 20100101

• Metabolic activity and mRNA levels of human cardiac CYP450s involved in drug metabolism.

  PloS one 20100101

• Quinidine depresses the transmural electrical heterogeneity of transient outward potassium current of the right ventricular outflow tract free wall.

  Journal of cardiovascular disease research 20100101

• Cisatracurium in different doses versus atracurium during general anesthesia for abdominal surgery.

  Saudi journal of anaesthesia 20100101

• The effect of acyclovir on the tubular secretion of creatinine in vitro.

  Journal of translational medicine 20100101

• New and emerging therapeutic agents for the treatment of fibromyalgia: an update.

  Journal of pain research 20100101

• General anaesthesia for insertion of an automated implantable cardioverter defibrillator in a child with Brugada and autism.

  Indian journal of anaesthesia 20100101

• Modulation of the p-glycoproein-mediated intestinal secretion of glibenclamide: in vitro and in vivo assessments.

  Journal of young pharmacists : JYP 20100101

• Newer antithrombotic drugs.

  Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 20100101

• Evidence of active transport involvement in morphine transport via MDCKII and MDCK-PGP cell lines.

  Research in pharmaceutical sciences 20100101

• Theory and developments in an unobtrusive cardiovascular system representation: ballistocardiography.

  The open biomedical engineering journal 20100101

• Role of posaconazole in the treatment of oropharyngeal candidiasis.

  Infection and drug resistance 20100101

• Beyond reverse pharmacology: Mechanism-based screening of Ayurvedic drugs.

  Journal of Ayurveda and integrative medicine 20100101

• Stereoselective Inhibition of the hERG1 Potassium Channel.

  Frontiers in pharmacology 20100101

• Antiplatelet therapy in acute coronary syndromes: focus on ticagrelor.

  Journal of blood medicine 20100101

• Impact of anti-cancer drugs and other determinants on serum protein binding of morphine 6-glucuronide.

  Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20100101

• Rapid LC-MS drug metabolite profiling using microsomal enzyme bioreactors in a parallel processing format.

  Analytical chemistry 20091215

• Asymmetric synthesis of fluorinated flavanone derivatives by an organocatalytic tandem intramolecular oxa-Michael addition/electrophilic fluorination reaction by using bifunctional cinchona alkaloids.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20091214

• Quinidine therapy in children affected by Brugada syndrome: are we far from a safe alternative?

  Cardiology in the young 20091201

• Further study on mefloquine concerning several aspects in experimental treatment of mice and hamsters infected with Schistosoma japonicum.

  Parasitology research 20091201

• Influence of quinidine, cimetidine, and ketoconazole on the enantioselective pharmacokinetics and metabolism of metoprolol in rats.

  Chirality 20091101

• Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome.

  Journal of molecular and cellular cardiology 20091101

• A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study.

  Biomedical chromatography : BMC 20091101

• A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel.

  Analytical biochemistry 20091101

• Tanshinone IIA protects against sudden cardiac death induced by lethal arrhythmias via repression of microRNA-1.

  British journal of pharmacology 20091101

• (5-Ethenyl-1-aza-bicyclo-[2.2.2]octan-2-yl)(6-meth-oxy-3-quinol-yl)methanol methanol solvate.

  Acta crystallographica. Section E, Structure reports online 20091101

• Regional differences in capillary density, perfusion rate, and P-glycoprotein activity: a quantitative analysis of regional drug exposure in the brain.

  Biochemical pharmacology 20091015

• Cardiomyocyte differentiation of human induced pluripotent stem cells.

  Circulation 20091013

• Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology.

  Neurology 20091013

• Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s.

  Chemico-biological interactions 20091007

• Pharmacological changes in cellular Ca2+ homeostasis parallel initiation of atrial arrhythmogenesis in murine Langendorff-perfused hearts.

  Clinical and experimental pharmacology & physiology 20091001

• [Idiosyncratic drug-induced thrombocytopenia].

  La Revue de medecine interne 20091001

• In vitro antimalarial interactions between mefloquine and cytochrome P450 inhibitors.

  Acta tropica 20091001

• Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment.

  Molecular pharmacology 20091001

• Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of p-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine.

  Drug metabolism and disposition: the biological fate of chemicals 20091001

• Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.

  Bioorganic & medicinal chemistry 20091001

• Effects of dextromethorphan/quinidine on auditory event-related potentials in multiple sclerosis patients with pseudobulbar affect.

  Journal of clinical psychopharmacology 20091001

• Involuntary emotional expression disorder in Alzheimer's disease - psychopharmacotherapy aspects.

  Psychiatria Danubina 20090901

• Inhibitory effects of ketoconazole, cimetidine and erythromycin on hepatic CYP3A activities in cats.

  The Journal of veterinary medical science 20090901

• Influence of peripheral groups on the physical and chemical behavior of cinchona alkaloids.

  The journal of physical chemistry. B 20090827

• Influence of efflux transporters on liver, bile and brain disposition of amitriptyline in mice.

  International journal of pharmaceutics 20090813

• Bifunctional catalysis by natural cinchona alkaloids: a mechanism explained.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20090810

• Electrical storm reversible by isoproterenol infusion in a striking case of early repolarization.

  Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20090801

• Vitreal kinetics of quinidine in rabbits in the presence of topically coadministered P-glycoprotein substrates/modulators.

  Drug metabolism and disposition: the biological fate of chemicals 20090801

• Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers.

  Drug metabolism and disposition: the biological fate of chemicals 20090801

• Excitatory effects of gap junction blockers on cerebral cortex seizure-like activity in rats and mice.

  Epilepsia 20090801

• Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting.

  American journal of physiology. Gastrointestinal and liver physiology 20090801

• Mechanisms and clinical management of inherited channelopathies: long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome.

  Heart rhythm 20090801

• Recent advances in pharmacotherapy of atrial fibrillation.

  Indian journal of pharmacology 20090801

• Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance.

  Current cardiology reviews 20090801

• Enantioselective plasma protein binding of propafenone: mechanism, drug interaction, and species difference.

  Chirality 20090701

• Biowaiver monographs for immediate release solid oral dosage forms: quinidine sulfate.

  Journal of pharmaceutical sciences 20090701

• Atrial arrhythmogenesis in wild-type and Scn5a+/delta murine hearts modelling LQT3 syndrome.

  Pflugers Archiv : European journal of physiology 20090701

• Probing the mechanisms underlying modulation of quinidine sensitivity to cardiac I(Ks) block by protein kinase A-mediated I(Ks) phosphorylation.

  British journal of pharmacology 20090701

• The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel.

  Journal of cardiovascular pharmacology 20090701

• Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols.

  PLoS neglected tropical diseases 20090701

• Building disease-specific drug-protein connectivity maps from molecular interaction networks and PubMed abstracts.

  PLoS computational biology 20090701

• (1α,8β)-6β-Benzo-yloxy-6-dehydroxy-heteratisine from Aconitum zeravschanicum.

  Acta crystallographica. Section E, Structure reports online 20090701

• Antiarrhythmic drug-induced internalization of the atrial-specific k+ channel kv1.5.

  Circulation research 20090619

• A comparison of the effects of p-glycoprotein inhibitors on the blood-brain barrier permeation of cyclic prodrugs of an opioid peptide (DADLE).

  Journal of pharmaceutical sciences 20090601

• Ligand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selection.

  Drug metabolism and disposition: the biological fate of chemicals 20090601

• The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport.

  The AAPS journal 20090601

• Functional expression, inhibition and induction of CYP enzymes in HepaRG cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20090601

• Quinacrine and a novel apigenin dimer can synergistically increase the pentamidine susceptibility of the protozoan parasite Leishmania.

  The Journal of antimicrobial chemotherapy 20090601

• Stereoselective differences in the cytochrome P450-dependent dealkylation and demethylenation of N-methyl-benzodioxolyl-butanamine (MBDB, Eden) enantiomers.

  Biochemical pharmacology 20090601

• Effects of antiarrhythmic drugs on the hyperpolarization-activated cyclic nucleotide-gated channel current.

  Journal of pharmacological sciences 20090601

• Electrical storm in Brugada syndrome successfully treated with orciprenaline; effect of low-dose quinidine on the electrocardiogram.

  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20090501

• Effects of quinidine on antinociception and pharmacokinetics of morphine in rats.

  The Journal of pharmacy and pharmacology 20090501

• Pharmacological characteristics and clinical applications of K201.

  Current clinical pharmacology 20090501

• Functional interaction between purinergic system and opioid withdrawal: in vitro evidence.

  Current drug safety 20090501

• Managing toxicities and optimal dosing of targeted drugs in advanced kidney cancer.

  Current oncology (Toronto, Ont.) 20090501

• Development of an in-capillary approach to nanoscale automated in vitro cytochromes p450 assays.

  Journal of medicinal chemistry 20090423

• Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: proof-of-concept study with aflatoxin B1.

  Chemico-biological interactions 20090415

• A cell-based sensor system for toxicity testing using multiwavelength fluorescence spectroscopy.

  Analytical biochemistry 20090415

• Recycling the tert-butanesulfinyl group in the synthesis of amines using tert-butanesulfinamide.

  The Journal of organic chemistry 20090403

• Grapefruit juice and its constituents augment colchicine intestinal absorption: potential hazardous interaction and the role of p-glycoprotein.

  Pharmaceutical research 20090401

• Unbound drug concentration in brain homogenate and cerebral spinal fluid at steady state as a surrogate for unbound concentration in brain interstitial fluid.

  Drug metabolism and disposition: the biological fate of chemicals 20090401

• The Registry of the German Competence NETwork on Atrial Fibrillation: patient characteristics and initial management.

  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20090401

• A preliminary assessment of the effects of ATI-2042 in subjects with paroxysmal atrial fibrillation using implanted pacemaker methodology.

  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20090401

• Quinidine revisited.

  The American journal of medicine 20090401

• Quinidine for pharmacological cardioversion of atrial fibrillation: a retrospective analysis in 501 consecutive patients.

  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20090401

• [Enzyme kinetics of ligustilide metabolism in rat liver microsomes].

  Yao xue xue bao = Acta pharmaceutica Sinica 20090401

• Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: animal and human studies.

  Progress in neuro-psychopharmacology & biological psychiatry 20090317

• Possible participation of chloride ion channels in ATP release from cancer cells in suspension.

  Clinical and experimental pharmacology & physiology 20090301

• Pinoline may be used as a probe for CYP2D6 activity.

  Drug metabolism and disposition: the biological fate of chemicals 20090301

• Empiric quinidine therapy for asymptomatic Brugada syndrome: time for a prospective registry.

  Heart rhythm 20090301

• One small step.

  Pacing and clinical electrophysiology : PACE 20090301

• Excellent long-term reproducibility of the electrophysiologic efficacy of quinidine in patients with idiopathic ventricular fibrillation and Brugada syndrome.

  Pacing and clinical electrophysiology : PACE 20090301

• Recognition and management of drug-induced cytopenias: the example of idiosyncratic drug-induced thrombocytopenia.

  Expert opinion on drug safety 20090301

• [Muscle cramps--differential diagnosis and therapy].

  Medizinische Monatsschrift fur Pharmazeuten 20090301

• Implantable cardioverter-defibrillator implantation in a patient with atrial standstill.

  Yonsei medical journal 20090227

• Characteristics of recurrent ventricular fibrillation associated with inferolateral early repolarization role of drug therapy.

  Journal of the American College of Cardiology 20090217

• Idiopathic ventricular fibrillation 'Le Syndrome d'Haïssaguerre' and the fear of J waves.

  Journal of the American College of Cardiology 20090217

• Structure-activity relationship and studies on the molecular mechanism of leishmanicidal N,C-coupled arylisoquinolinium salts.

  Journal of medicinal chemistry 20090212

• Arrhythmogenic actions of the Ca2+ channel agonist FPL-64716 in Langendorff-perfused murine hearts.

  Experimental physiology 20090201

• The carnitine transporter SLC22A5 is not a general drug transporter, but it efficiently translocates mildronate.

  Drug metabolism and disposition: the biological fate of chemicals 20090201

• Insight into the effects of chiral isomers quinidine and quinine on CYP2D6 inhibition.

  Bioorganic & medicinal chemistry letters 20090201

• Separation of Cinchona alkaloids on a novel strong cation-exchange-type chiral stationary phase-comparison with commercially available strong cation exchanger and reversed-phase packing materials.

  Analytical and bioanalytical chemistry 20090201

• Simultaneous liquid chromatographic analysis of ritonavir, quinine and 3-hydroxyquinine in human plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090201

• Use of propafenone for conversion of chronic atrial fibrillation in horses.

  American journal of veterinary research 20090201

• Regulation of antiarrhythmic drug propafenone effects on the c-type Kv1.4 potassium channel by PHo and K+.

  Journal of Korean medical science 20090201

• Determination of nicardipine and amlodipine in human plasma using on-line solid-phase extraction with a monolithic weak cation-exchange column.

  Talanta 20090115

• In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes.

  Stem cells and development 20090101

• Fatal transfusion-transmitted Babesia microti in the Midwest.

  Transfusion 20090101

• Enantioselective complexation of carbamoylated quinine and quinidine with N-blocked amino acids: vibrational and electronic circular dichroism study.

  Analytical and bioanalytical chemistry 20090101

• Discovering plausible mechanistic details of hepatic drug interactions.

  Drug metabolism and disposition: the biological fate of chemicals 20090101

• Inhibition of P-glycoprotein-mediated paclitaxel resistance by reversibly linked quinine homodimers.

  Molecular pharmacology 20090101

• In vitro nimesulide studies toward understanding idiosyncratic hepatotoxicity: diiminoquinone formation and conjugation.

  Chemical research in toxicology 20090101

• Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes.

  Chemical research in toxicology 20090101

• Ventricular fibrillation with prominent early repolarization associated with a rare variant of KCNJ8/KATP channel.

  Journal of cardiovascular electrophysiology 20090101

• Involvement of P-glycoprotein and multidrug resistance associated protein 1 on the transepithelial transport of a mercaptoacetamide-based histone-deacetylase inhibitor in Caco-2 cells.

  Biological & pharmaceutical bulletin 20090101

• Expression and functional characterization of choline transporter in human keratinocytes.

  Journal of pharmacological sciences 20090101

• Does artesunate prolong the electrocardiograph QT interval in patients with severe malaria?

  The American journal of tropical medicine and hygiene 20090101

• Organic cation/carnitine transporter family expression patterns in adult murine heart.

  Pathology, research and practice 20090101

• Segmental dependent transport of low permeability compounds along the small intestine due to P-glycoprotein: the role of efflux transport in the oral absorption of BCS class III drugs.

  Molecular pharmaceutics 20090101

• Assessing the efficiency of mixed effects modelling in quantifying metabolism based drug-drug interactions: using in vitro data as an aid to assess study power.

  Pharmaceutical statistics 20090101

• Protandim, a fundamentally new antioxidant approach in chemoprevention using mouse two-stage skin carcinogenesis as a model.

  PloS one 20090101

• Drug-induced esophagitis.

  Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20090101

• [Plasmodium falciparum malaria acquired in Sub-Saharan Africa].

  Medicina 20090101

• Early repolarization electrocardiography pattern with unexplained syncope during training in a young black African non-elite athlete: an accidental finding?

  Cardiology journal 20090101

• Electrical cardioversion.

  Annals of Saudi medicine 20090101

• Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma.

  BMC urology 20090101

• Atomoxetine for the treatment of attention-deficit/hyperactivity disorder in children and adolescents: a review.

  Neuropsychiatric disease and treatment 20090101

• Characterization of voltage-gated potassium channels in human neural progenitor cells.

  PloS one 20090101

• Extracellular potassium dependency of block of HERG by quinidine and cisapride is primarily determined by the permeant ion and not by inactivation.

  Channels (Austin, Tex.) 20090101

• A cardiologic approach to non-insulin antidiabetic pharmacotherapy in patients with heart disease.

  Cardiovascular diabetology 20090101

• Epileptogenic potential of mefloquine chemoprophylaxis: a pathogenic hypothesis.

  Malaria journal 20090101

• Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells.

  Journal of biomedicine & biotechnology 20090101

• Extracorporeal life support in severe drug intoxication: a retrospective cohort study of seventeen cases.

  Critical care (London, England) 20090101

• Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation.

  PloS one 20090101

• Update on babesiosis.

  Interdisciplinary perspectives on infectious diseases 20090101

• Changes in frequency of spontaneous oscillations in procerebrum correlate to behavioural choice in terrestrial snails.

  Frontiers in cellular neuroscience 20090101

• The use of oral ranolazine to convert new or paroxysmal atrial fibrillation: a review of experience with implications for possible 'pill in the pocket' approach to atrial fibrillation.

  Indian pacing and electrophysiology journal 20090101

• Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons.

  PloS one 20090101

• The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast tumors.

  BMC cancer 20090101

• Short QT syndrome: a review.

  Cardiology in review 20090101

• Comparative study of increased plasma quinidine concentration in rats with glycerol- and cisplatin-induced acute renal failure.

  Drug metabolism and pharmacokinetics 20090101

• Genetic variations of the SLC22A4 gene in Chinese and Indian populations of Singapore.

  Drug metabolism and pharmacokinetics 20090101

• A human hepatocyte-bearing mouse: an animal model to predict drug metabolism and effectiveness in humans.

  PPAR research 20090101

• Atrial fibrillation in cardiac channelopathies.

  Indian pacing and electrophysiology journal 20090101

• Effect of magnetic nanoparticles of Fe3O4 and 5-bromotetrandrine on reversal of multidrug resistance in K562/A02 leukemic cells.

  International journal of nanomedicine 20090101

• Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent.

  PloS one 20090101

• Is newer better? Propafenone versus quinidine for conversion of atrial fibrillation.

  Cardiology journal 20090101

• Efficacy and tolerability of oral propafenone versus quinidine in the treatment of recent onset atrial fibrillation: A randomized, prospective study.

  Cardiology journal 20090101

• Quality of malaria case management at outpatient health facilities in Angola.

  Malaria journal 20090101

• Drug-induced hematologic syndromes.

  Advances in hematology 20090101

• Short-term and long-term success of electrical cardioversion in atrial fibrillation in managed care system.

  International archives of medicine 20090101

• Role of multidrug transporters in neurotherapeutics.

  Annals of Indian Academy of Neurology 20090101

• Digoxin in management of heart failure in children: Should it be continued or relegated to the history books?

  Annals of pediatric cardiology 20090101

• Genetic testing in specific cardiomyopathies.

  F1000 medicine reports 20090101

• Intermittent weakness and mediastinal weakening.

  McGill journal of medicine : MJM : an international forum for the advancement of medical sciences by students 20090101

• Improving glycemic and cholesterol control through an integrated approach incorporating colesevelam - a clinical perspective.

  Diabetes, metabolic syndrome and obesity : targets and therapy 20090101

• Role of darunavir in the management of HIV infection.

  HIV/AIDS (Auckland, N.Z.) 20090101

• In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.

  Journal of medicinal chemistry 20081225

• 2,5-Dimethoxyamphetamine-derived designer drugs: studies on the identification of cytochrome P450 (CYP) isoenzymes involved in formation of their main metabolites and on their capability to inhibit CYP2D6.

  Toxicology letters 20081215

• Tuning of synaptic integration in the medial entorhinal cortex to the organization of grid cell firing fields.

  Neuron 20081210

• Pharmacophore based discovery of potential antimalarial agent targeting haem detoxification pathway.

  European journal of medicinal chemistry 20081201

• Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition.

  Archives of toxicology 20081201

• Modulating effect of polyethylene glycol on the intestinal transport and absorption of prednisolone, methylprednisolone and quinidine in rats by in-vitro and in-situ absorption studies.

  The Journal of pharmacy and pharmacology 20081201

• Termination of equine atrial fibrillation by quinidine: an optical mapping study.

  Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 20081201

• Enhancement by grapefruit juice of morphine antinociception.

  Biological & pharmaceutical bulletin 20081201

• Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine.

  Heart rhythm 20081201

• Synergistic effects on enantioselectivity of zwitterionic chiral stationary phases for separations of chiral acids, bases, and amino acids by HPLC.

  Analytical chemistry 20081115

• Drug binding to the inactivated state is necessary but not sufficient for high-affinity binding to human ether-à-go-go-related gene channels.

  Molecular pharmacology 20081101

• Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs.

  British journal of pharmacology 20081101

• Effect of CYP2D6 polymorphism on pharmacokinetics of a novel ACAT inhibitor, pactimibe and its unique metabolite, R-125528.

  International journal of clinical pharmacology and therapeutics 20081101

• Influence of quinidine, fluvoxamine, and ketoconazole on the enantioselective pharmacokinetics of citalopram in rats.

  Canadian journal of physiology and pharmacology 20081101

• A PI3-kinase-mediated negative feedback regulates neuronal excitability.

  PLoS genetics 20081101

• Validation of the use of nonnaive surgically catheterized rats for pharmacokinetics studies.

  Journal of the American Association for Laboratory Animal Science : JAALAS 20081101

• Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.

  Journal of medicinal chemistry 20081009

• Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.

  Journal of medicinal chemistry 20081009

• Physiological consequences of the P2328S mutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts.

  Acta physiologica (Oxford, England) 20081001

• Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone.

  Drug metabolism and disposition: the biological fate of chemicals 20081001

• Improving resolution in single-scan 2D spectroscopy.

  Journal of magnetic resonance (San Diego, Calif. : 1997) 20081001

• Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1.

  Biochemical pharmacology 20081001

• Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84).

  Biochemical pharmacology 20081001

• Identification of cytochrome P450 enzymes involved in the metabolism of the designer drugs N-(1-phenylcyclohexyl)-3-ethoxypropanamine and N-(1-phenylcyclohexyl)-3-methoxypropanamine.

  Chemical research in toxicology 20081001

• Successful conversion of recent-onset atrial fibrillation by sequential administration of up to three antiarrhythmic drugs.

  Clinical cardiology 20081001

• Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations.

  Current drug metabolism 20081001

• On Brugada syndrome.

  The Israel Medical Association journal : IMAJ 20081001

• Therapeutic strategies in congenital myasthenic syndromes.

  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20081001

• Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties.

  Progress in biophysics and molecular biology 20081001

• Malaria and hereditary elliptocytosis.

  American journal of hematology 20080901

• Muscle cramps in cirrhosis: the therapeutic value of quinine. Is it underused?

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20080901

• A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation.

  Drug metabolism and disposition: the biological fate of chemicals 20080901

• Monoaminergic modulation of the Na+-activated K+ channel in Kenyon cells isolated from the mushroom body of the cricket (Gryllus bimaculatus) brain.

  Journal of neurophysiology 20080901

• In silico risk assessment for drug-induction of cardiac arrhythmia.

  Progress in biophysics and molecular biology 20080901

• Marked impact of P-glycoprotein on the absorption of TAK-427 in rats.

  Biopharmaceutics & drug disposition 20080901

• Effect of cationic drugs on the transporting activity of human and rat OCT/Oct 1-3 in vitro and implications for drug-drug interactions.

  Xenobiotica; the fate of foreign compounds in biological systems 20080901

• The use of phosphodiesterase 5 inhibitors with concomitant medications.

  Journal of endocrinological investigation 20080901

• [Effects of cytochrome P450 isozymes on aristolochic acid renal cytotoxicity].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

• Dextromethorphan/quinidine sulfate for pseudobulbar affect.

  Drugs of today (Barcelona, Spain : 1998) 20080901

• Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.

  Journal of medicinal chemistry 20080828

• Interaction of coenzyme Q10 with the intestinal drug transporter P-glycoprotein.

  Journal of agricultural and food chemistry 20080827

• Transvenous electrical cardioversion of atrial fibrillation in six horses using custom made cardioversion catheters.

  Veterinary journal (London, England : 1997) 20080801

• Effects of ketoconazole and quinidine on pharmacokinetics of pactimibe and its plasma metabolite, R-125528, in humans.

  Drug metabolism and disposition: the biological fate of chemicals 20080801

• The crystal structure of halofantrine-ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials.

  Journal of inorganic biochemistry 20080801

• Psychiatric disorders and traumatic brain injury.

  Neuropsychiatric disease and treatment 20080801

• Posaconazole in the management of refractory invasive fungal infections.

  Therapeutics and clinical risk management 20080801

• The Relationship Between HIV Infection and Cardiovascular Disease.

  Current cardiology reviews 20080801

• Safety considerations in the pharmacological management of atrial fibrillation.

  International journal of cardiology 20080721

• Electrical storm in a patient with arrhythmogenic right ventricular cardiomyopathy and SCN5A mutation.

  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20080701

• Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.

  Drug metabolism and disposition: the biological fate of chemicals 20080701

• Validation and application of Caco-2 assays for the in vitro evaluation of development candidate drugs as substrates or inhibitors of P-glycoprotein to support regulatory submissions.

  Xenobiotica; the fate of foreign compounds in biological systems 20080701

• Neuromuscular junctional disorders.

  Indian journal of pediatrics 20080701

• Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

  Journal of medicinal chemistry 20080612

• Hepatic uptake and excretion of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a novel if channel inhibitor, in rats and humans.

  Drug metabolism and disposition: the biological fate of chemicals 20080601

• Integrated in vitro analysis for the in vivo prediction of cytochrome P450-mediated drug-drug interactions.

  Drug metabolism and disposition: the biological fate of chemicals 20080601

• Indolealkylamines: biotransformations and potential drug-drug interactions.

  The AAPS journal 20080601

• Additive effects of combined application of multiple hERG blockers.

  Journal of cardiovascular pharmacology 20080601

• Successful radiofrequency catheter ablation for electrical storm of ventricular fibrillation in a patient with Brugada syndrome.

  Circulation journal : official journal of the Japanese Circulation Society 20080601

• Stereoselective oxidation and glucuronidation of carvedilol in human liver and intestinal microsomes.

  Biological & pharmaceutical bulletin 20080601

• Application of multivariate methods to the simultaneous Fourier Transform Infrared (FT-IR) spectrometric determination of stereo-isomers; quinine and quinidine.

  Chemical & pharmaceutical bulletin 20080601

• In situ intestinal absorption of cyclosporine A solid dispersion in rats.

  Drug development and industrial pharmacy 20080601

• The causes and treatment of pseudobulbar affect in ischemic stroke.

  Current treatment options in cardiovascular medicine 20080601

• Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical.

  The AAPS journal 20080601

• Weak cation-exchange restricted-access material for on-line purification of basic drugs in plasma.

  Journal of chromatography. A 20080509

• Effects of potassium channel openers in the isolated perfused hypokalaemic murine heart.

  Acta physiologica (Oxford, England) 20080501

• The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080501

• Detection of novel reactive metabolites of trazodone: evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine.

  Drug metabolism and disposition: the biological fate of chemicals 20080501

• Functional expression of the voltage-gated neuronal mammalian potassium channel rat ether à go-go1 in yeast.

  FEMS yeast research 20080501

• Scaling of in vitro membrane permeability to predict P-glycoprotein-mediated drug absorption in vivo.

  Drug metabolism and disposition: the biological fate of chemicals 20080501

• Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice.

  The Journal of pharmacology and experimental therapeutics 20080501

• Modest effect of impaired P-glycoprotein on the plasma concentrations of fexofenadine, quinidine, and loperamide following oral administration in collies.

  Drug metabolism and disposition: the biological fate of chemicals 20080501

• Brain levels of dextromethorphan and the intensity of opioid withdrawal in mice.

  Drug and alcohol dependence 20080501

• Molecular modelling of human CYP2D6 and molecular docking of a series of ajmalicine- and quinidine-like inhibitors.

  International journal of biological macromolecules 20080501

• Clinical and molecular genetics of the short QT syndrome.

  Current opinion in cardiology 20080501

• Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.

  Journal of medicinal chemistry 20080410

• Biotransformation and pharmacokinetics of the novel anticancer drug, SYUIQ-5, in the rat.

  Investigational new drugs 20080401

• Pharmacological separation of early afterdepolarizations from arrhythmogenic substrate in DeltaKPQ Scn5a murine hearts modelling human long QT 3 syndrome.

  Acta physiologica (Oxford, England) 20080401

• Cellular basis for arrhythmogenesis in an experimental model of the SQT1 form of the short QT syndrome.

  Heart rhythm 20080401

• hERG: the long and short of it.

  Heart rhythm 20080401

• Nitric oxide is involved in appetitive but not aversive olfactory learning in the land mollusk Limax valentianus.

  Learning & memory (Cold Spring Harbor, N.Y.) 20080401

• Insulin increases excitability via a dose-dependent dual inhibition of voltage-activated K+ currents in differentiated N1E-115 neuroblastoma cells.

  The European journal of neuroscience 20080401

• [Treatment of rheumatic valvular disease complicated by atrial fibrillation with quinidine in 11 children].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20080401

• A review on the impact of P-glycoprotein on the penetration of drugs into the brain. Focus on psychotropic drugs.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080301

• An improved synthesis of 10,11-didehydro Cinchona alkaloids.

  Chirality 20080301

• Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.

  British journal of pharmacology 20080301

• In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier.

  Drug metabolism and disposition: the biological fate of chemicals 20080301

• Fate of quinidine, a P-glycoprotein substrate, in the gastrointestinal tract after oral administration in rats.

  Die Pharmazie 20080301

• Modification of K+ channel-drug interactions by ancillary subunits.

  The Journal of physiology 20080215

• Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity.

  Investigational new drugs 20080201

• Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells.

  Drug metabolism and disposition: the biological fate of chemicals 20080201

• Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases.

  Xenobiotica; the fate of foreign compounds in biological systems 20080201

• Transfusion-transmitted malaria in a kidney transplant recipient. How safe is our blood transfusion?

  Saudi medical journal 20080201

• Cost-effectiveness of implantable cardioverter-defibrillators in Brugada syndrome treatment.

  Journal of medical systems 20080201

• Carvedilol in hypertension treatment.

  Vascular health and risk management 20080201

• Highly enantioselective Michael addition of malononitrile to alpha,beta-unsaturated ketones.

  Organic & biomolecular chemistry 20080121

• Protein concentration and pH affect the apparent P-glycoprotein-ATPase activation kinetics.

  International journal of pharmaceutics 20080104

• Criteria for arrhythmogenicity in genetically-modified Langendorff-perfused murine hearts modelling the congenital long QT syndrome type 3 and the Brugada syndrome.

  Pflugers Archiv : European journal of physiology 20080101

• Effect of P-glycoprotein expression levels on the concentration-dependent permeability of drugs to the cell membrane.

  Journal of pharmaceutical sciences 20080101

• Magnesium-calcium signalling in rat parotid acinar cells: effects of acetylcholine.

  Molecular and cellular biochemistry 20080101

• Identification of cytochrome P450 enzymes involved in the metabolism of the new designer drug 4'-methyl-alpha-pyrrolidinobutyrophenone.

  Drug metabolism and disposition: the biological fate of chemicals 20080101

• Optimisation and validation of a medium-throughput electrophysiology-based hNav1.5 assay using IonWorks.

  Journal of pharmacological and toxicological methods 20080101

• The additive effects of the active component of grapefruit juice (naringenin) and antiarrhythmic drugs on HERG inhibition.

  Cardiology 20080101

• Extracellular acidification and hyperkalemia induce changes in HERG inhibition by ibutilide.

  Cardiology 20080101

• Going beyond efficacy: strategies for cancer pain management.

  Current oncology (Toronto, Ont.) 20080101

• Effect of chemosensitizers on minimum inhibitory concentrations of fluconazole in Candida albicans.

  Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20080101

• Collateral effects of antiarrhythmics in pediatric age.

  Current pharmaceutical design 20080101

• CYP2D6 is primarily responsible for the metabolism of clomiphene.

  Drug metabolism and pharmacokinetics 20080101

• Low-level quinolone-resistance in multi-drug resistant typhoid.

  Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20080101

• Dextromethorphan and quinidine combination for heroin detoxification.

  The American journal on addictions 20080101

• Pediatric electrophysiology in India: a sub-speciality come of age.

  Indian pacing and electrophysiology journal 20080101

• Device therapy in children: current indications.

  Indian pacing and electrophysiology journal 20080101

• Genetics of inherited arrhythmias in children.

  Indian pacing and electrophysiology journal 20080101

• Inherited arrhythmias in children.

  Indian pacing and electrophysiology journal 20080101

• Social uses of personal health information within PatientsLikeMe, an online patient community: what can happen when patients have access to one another's data.

  Journal of medical Internet research 20080101

• Laugh syncope as a rare sub-type of the situational syncopes: a case report.

  Journal of medical case reports 20080101

• Involvement of carnitine/organic cation transporter OCTN2 (SLC22A5) in distribution of its substrate carnitine to the heart.

  Drug metabolism and pharmacokinetics 20080101

• Genome-wide compensatory changes accompany drug- selected mutations in the Plasmodium falciparum crt gene.

  PloS one 20080101

• Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart.

  Journal of pharmacological and toxicological methods 20080101

• Quality of anticoagulation and use of warfarin-interacting medications in long-term care: a chart review.

  BMC geriatrics 20080101

• [New indications of quinidine rescue it from the forgotten].

  Revista clinica espanola 20080101

• Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes.

  PloS one 20080101

• Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds.

  Journal of pharmacological and toxicological methods 20080101

• Antimalarial therapy selection for quinolone resistance among Escherichia coli in the absence of quinolone exposure, in tropical South America.

  PloS one 20080101

• Drug therapy considerations in arrhythmias in children.

  Indian pacing and electrophysiology journal 20080101

• ECG phenomena of the early ventricular repolarization in the 21 century.

  Indian pacing and electrophysiology journal 20080101

• Formation of the food vacuole in Plasmodium falciparum: a potential role for the 19 kDa fragment of merozoite surface protein 1 (MSP1(19)).

  PloS one 20080101

• Toward a comprehensive approach to the collection and analysis of pica substances, with emphasis on geophagic materials.

  PloS one 20080101

• Cellular mechanisms underlying the laxative effect of flavonol naringenin on rat constipation model.

  PloS one 20080101

• Role of cytochrome P450 in drug interactions.

  Nutrition & metabolism 20080101

• The prince and the pauper. A tale of anticancer targeted agents.

  Molecular cancer 20080101

• Chloroquine-resistant Plasmodium vivax malaria in Debre Zeit, Ethiopia.

  Malaria journal 20080101

• A novel approach to the prediction of drug-drug interactions in humans based on the serum incubation method.

  Drug metabolism and pharmacokinetics 20080101

• Directional transcellular transport of bisoprolol in P-glycoprotein-expressed LLC-GA5-COL150 cells, but not in renal epithelial LLC-PK1 Cells.

  Drug metabolism and pharmacokinetics 20080101

• Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury.

  Critical care (London, England) 20080101

• MFS transportome of the human pathogenic yeast Candida albicans.

  BMC genomics 20080101

• Chemical-genetic profile analysis in yeast suggests that a previously uncharacterized open reading frame, YBR261C, affects protein synthesis.

  BMC genomics 20080101

• Short QT syndrome. Update on a recent entity.

  Archives of cardiovascular diseases 20080101

• Opposed circulating plasma levels of endothelin-1 and C-type natriuretic peptide in children with Plasmodium falciparum malaria.

  Malaria journal 20080101

• Evaluation of the inhibitory and induction potential of YM758, a novel If channel inhibitor, for human P450-mediated metabolism.

  European journal of drug metabolism and pharmacokinetics 20080101

• Atrial fibrillation (acute onset).

  BMJ clinical evidence 20080101

• Early detection of allergic diseases in otorhinolaryngology.

  GMS current topics in otorhinolaryngology, head and neck surgery 20080101

• Defeating cancer with antidepressants.

  Ecancermedicalscience 20080101

• Factors controlling adsorption equilibria from solution onto solid surfaces: the uptake of cinchona alkaloids on platinum surfaces.

  Journal of the American Chemical Society 20071226

• TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones.

  The Journal of physiology 20071215

• Quinidine: a valuable medication joins the list of 'endangered species'.

  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20071201

• In vitro metabolism of the analgesic bicifadine in the mouse, rat, monkey, and human.

  Drug metabolism and disposition: the biological fate of chemicals 20071201

• Characterization of phenoloxidase activity in Sydney rock oysters (Saccostrea glomerata).

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20071201

• Review of duloxetine in the management of diabetic peripheral neuropathic pain.

  Vascular health and risk management 20071201

• Paliperidone ER: a review of the clinical trial data.

  Neuropsychiatric disease and treatment 20071201

• Sodium-dependent potassium channels of a Slack-like subtype contribute to the slow afterhyperpolarization in lamprey spinal neurons.

  The Journal of physiology 20071115

• Acid-sensing ion channels contribute to transduction of extracellular acidosis in rat carotid body glomus cells.

  Circulation research 20071109

• In vivo bicarbonate requirement for water oxidation by Photosystem II in the hypercarbonate-requiring cyanobacterium Arthrospira maxima.

  Journal of inorganic biochemistry 20071101

• In vivo effects of mutant HERG K+ channel inhibition by disopyramide in patients with a short QT-1 syndrome: a pilot study.

  Journal of cardiovascular electrophysiology 20071101

• The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol.

  Basic & clinical pharmacology & toxicology 20071101

• [Electrical storm].

  Annales de cardiologie et d'angeiologie 20071101

• Pharmacokinetic analysis of transcellular transport of levofloxacin across LLC-PK1 and Caco-2 cell monolayers.

  Biological & pharmaceutical bulletin 20071101

• [Experimental studies on antiarrhythmic effect of jumi extraction].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20071101

• Peripartum cardiomyopathy: review of the literature.

  Yonsei medical journal 20071031

• Chiral discrimination of quinine and quinidine based on notable room temperature phosphorescence lifetime differences with gamma-cyclodextrin as chiral selector.

  Talanta 20071031

• [Drug-induced thrombocytopenia].

  Nihon rinsho. Japanese journal of clinical medicine 20071028

• [Drug-induced hemolytic anemia].

  Nihon rinsho. Japanese journal of clinical medicine 20071028

• New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation.

  Journal of medicinal chemistry 20071018

• Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation.

  The Cochrane database of systematic reviews 20071017

• Two-pore-domain potassium channels contribute to neuronal potassium release and glial potassium buffering in the rat hippocampus.

  Brain research 20071010

• Stealth dendrimers for antiarrhythmic quinidine delivery.

  Journal of materials science. Materials in medicine 20071001

• Staurosporine-induced cell death in salmonid cells: the role of apoptotic volume decrease, ion fluxes and MAP kinase signaling.

  Apoptosis : an international journal on programmed cell death 20071001

• Characterization of cytochrome P450-mediated drug metabolism in cats.

  Journal of veterinary pharmacology and therapeutics 20071001

• Effect of calcium-channel antagonist on repolarization heterogeneity of ventricular myocardium in an in vitro rabbit model of long QT syndrome.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20071001

• Colesevelam hydrochloride: reducing atherosclerotic coronary heart disease risk factors.

  Vascular health and risk management 20071001

• [Metabolic products and pathway of neferine in rat liver].

  Yao xue xue bao = Acta pharmaceutica Sinica 20071001

• Malaria treatment in the United States.

  JAMA 20070926

• A quantitative analysis of the effect of cycle length on arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts.

  Pflugers Archiv : European journal of physiology 20070901

• IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation.

  Journal of cellular physiology 20070901

• Acute hepatotoxicity: a predictive model based on focused illumina microarrays.

  Toxicological sciences : an official journal of the Society of Toxicology 20070901

• Separation of early afterdepolarizations from arrhythmogenic substrate in the isolated perfused hypokalaemic murine heart through modifiers of calcium homeostasis.

  Acta physiologica (Oxford, England) 20070901

• In vitro assessment of cytochrome P450 inhibition: strategies for increasing LC/MS-based assay throughput using a one-point IC(50) method and multiplexing high-performance liquid chromatography.

  Journal of pharmaceutical sciences 20070901

• Decrease in intracellular concentration causes the shift in Km value of efflux pump substrates.

  Drug metabolism and disposition: the biological fate of chemicals 20070901

• Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra.

  Pharmaceutical research 20070901

• In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies.

  Toxicological sciences : an official journal of the Society of Toxicology 20070901

• [Death of the quinidine durules--their rise and fall].

  Lakartidningen 20070901

• It's nothing to laugh about: understanding disorders of emotional expression.

  The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20070901

• Therapeutic use of dextromethorphan: key learnings from treatment of pseudobulbar affect.

  Journal of the neurological sciences 20070815

• Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17.

  Drug metabolism and disposition: the biological fate of chemicals 20070801

• Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin.

  Biochemical pharmacology 20070801

• Cardiotoxicity of antimalarial drugs.

  The Lancet. Infectious diseases 20070801

• A clinical trial of topical bleaching treatment with nanoscale tretinoin particles and hydroquinone for hyperpigmented skin lesions.

  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20070801

• Treatment of chronic atrial fibrillation in the horse with flecainide: personal observation.

  Veterinary research communications 20070801

• Role of posaconazole in the management of oropharyngeal and esophageal candidiasis.

  Therapeutics and clinical risk management 20070801

• Involvement of P-glycoprotein and multidrug resistance associated protein 1 in the transport of tanshinone IIB, a primary active diterpenoid quinone from the roots of Salvia miltiorrhiza, across the blood-brain barrier.

  Drug metabolism letters 20070801

• Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.

  Biochemical pharmacology 20070715

• Probing the substrate specificity of the ergothioneine transporter with methimazole, hercynine, and organic cations.

  Biochemical pharmacology 20070715

• Frequency-dependent effects of various IKr blockers on cardiac action potential duration in a human atrial model.

  American journal of physiology. Heart and circulatory physiology 20070701

• In situ kinetic modelling of intestinal efflux in rats: functional characterization of segmental differences and correlation with in vitro results.

  Biopharmaceutics & drug disposition 20070701

• Timolol metabolism in human liver microsomes is mediated principally by CYP2D6.

  Drug metabolism and disposition: the biological fate of chemicals 20070701

• Molecular identification and functional characterization of rabbit MATE1 and MATE2-K.

  American journal of physiology. Renal physiology 20070701

• Development of a quantitative LC-MS/MS analytical method coupled with turbulent flow chromatography for digoxin for the in vitro P-gp inhibition assay.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701

• [Enzyme kinetics of schizandrin metabolism and sex differences in rat liver microsomes].

  Yao xue xue bao = Acta pharmaceutica Sinica 20070701

• Serum cardiac markers in patients with acute myocardial infarction: oxidative stress, C-reactive protein and N-terminal probrain natriuretic Peptide.

  Journal of clinical biochemistry and nutrition 20070701

• Synthesis and biological studies of novel 2-aminoalkylethers as potential antiarrhythmic agents for the conversion of atrial fibrillation.

  Journal of medicinal chemistry 20070614

• Species differences of inhibitory effects on P-glycoprotein-mediated drug transport.

  Journal of pharmaceutical sciences 20070601

• Proton modulation of ion channels in isolated horizontal cells of the goldfish retina.

  The Journal of physiology 20070601

• Reduction of dispersion of repolarization and prolongation of postrepolarization refractoriness explain the antiarrhythmic effects of quinidine in a model of short QT syndrome.

  Journal of cardiovascular electrophysiology 20070601

• Quinidine in short QT syndrome: an old drug for a new disease.

  Journal of cardiovascular electrophysiology 20070601

• Acute and chronic management in patients with Brugada syndrome associated with electrical storm of ventricular fibrillation.

  Heart rhythm 20070601

• Treatment of ventricular fibrillation storm in Brugada syndrome: weathering the storm but staying in hot water?

  Heart rhythm 20070601

• Role of P-glycoprotein in restricting the brain penetration of tanshinone IIA, a major active constituent from the root of Salvia miltiorrhiza Bunge, across the blood-brain barrier.

  Xenobiotica; the fate of foreign compounds in biological systems 20070601

• [Simultaneous determination of the inhibitory potency of compounds on the activity of five cytochrome P-450 enzymes using a cocktail probe substrates method].

  Yao xue xue bao = Acta pharmaceutica Sinica 20070601

• Psychiatric manifestations of neurologic disease: where are we headed?

  Dialogues in clinical neuroscience 20070601

• Solution phase enantioselective recognition and discrimination by electrospray ionization--mass spectrometry: state-of-the-art, methods, and an eye towards increased throughput measurements.

  Combinatorial chemistry & high throughput screening 20070601

• A brief review of moxifloxacin in the treatment of elderly patients with community-acquired pneumonia (CAP).

  Clinical interventions in aging 20070601

• Treatment of malaria in the United States: a systematic review.

  JAMA 20070523

• Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/- murine hearts modelling the Brugada syndrome.

  The Journal of physiology 20070515

• A Ba2+-resistant, acid-sensitive K+ conductance in Na+-absorbing H441 human airway epithelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20070501

• The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts.

  Pflugers Archiv : European journal of physiology 20070501

• Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein.

  The Journal of pharmacology and experimental therapeutics 20070501

• Kinetics of the time-dependent inactivation of CYP2D6 in cryopreserved human hepatocytes by methylenedioxymethamphetamine (MDMA).

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070501

• The neuropsychiatry of multiple sclerosis: a review of recent developments.

  Current opinion in psychiatry 20070501

• Dielectric relaxation and crystallization of ultraviscous melt and glassy states of aspirin, ibuprofen, progesterone, and quinidine.

  Journal of pharmaceutical sciences 20070501

• Effects of atorvastatin and simvastatin on atrial plateau currents.

  Journal of molecular and cellular cardiology 20070501

• [Short QT syndrome].

  Herz 20070501

• Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.

  Current drug metabolism 20070501

• Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier.

  Current drug metabolism 20070501

• Chronic arsenic exposure and cardiac repolarization abnormalities with QT interval prolongation in a population-based study.

  Environmental health perspectives 20070501

• In situ UV resonance Raman micro-spectroscopic localization of the antimalarial quinine in cinchona bark.

  The journal of physical chemistry. B 20070426

• Clinical aspects and prognosis of Brugada syndrome in children.

  Circulation 20070417

• Brugada syndrome in children: don't ask, don't tell?

  Circulation 20070417

• Quinidine-induced lupus anticoagulant, hypoprothrombinemia, and antiprothrombin antibodies.

  American journal of hematology 20070401

• The novel antimalarial compound dioncophylline C forms a complex with heme in solution.

  ChemMedChem 20070401

• A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents.

  Journal of cardiovascular electrophysiology 20070401

• Potassium channel blockers quinidine and caesium halt cell proliferation in C6 glioma cells via a polyamine-dependent mechanism.

  Biochemical Society transactions 20070401

• Drug-induced lupus associated with synthetic conjugated estrogens.

  The Annals of pharmacotherapy 20070401

• Does metronidazole interact with CYP3A substrates by inhibiting their metabolism through this metabolic pathway? Or should other mechanisms be considered?

  The Annals of pharmacotherapy 20070401

• The cutaneous analgesic effect of class I antiarrhythmic drugs.

  Anesthesia and analgesia 20070401

• One center's experience: the serology and drugs associated with drug-induced immune hemolytic anemia--a new paradigm.

  Transfusion 20070401

• The therapy of congenital myasthenic syndromes.

  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20070401

• Microbial transformation of dextromethorphan by Cunninghamella blakesleeana AS 3.153.

  Chemical & pharmaceutical bulletin 20070401

• Involuntary emotional expression disorder: treating the untreated.

  CNS spectrums 20070401

• Electrical storms in Brugada syndrome successfully treated with isoproterenol infusion and quinidine orally.

  Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 20070401

• Development and validation of RP-HPLC-UV method for simultaneous determination of buparvaquone, atenolol, propranolol, quinidine and verapamil: a tool for the standardization of rat in situ intestinal permeability studies.

  Journal of pharmaceutical and biomedical analysis 20070312

• A comparative pharmacokinetic study in healthy volunteers of the effect of carbamazepine and oxcarbazepine on cyp3a4.

  Epilepsia 20070301

• Neuropsychiatric consequences of cardiovascular medications.

  Dialogues in clinical neuroscience 20070301

• Cosmetic use of botulinum toxin type A in the elderly.

  Clinical interventions in aging 20070301

• Electrometric measurement of plasma, erythrocyte, and whole blood cholinesterase activities in healthy human volunteers.

  Journal of medical toxicology : official journal of the American College of Medical Toxicology 20070301

• Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist.

  Journal of medicinal chemistry 20070222

• Oral bioavailability and intestinal secretion of amitriptyline: Role of P-glycoprotein?

  International journal of pharmaceutics 20070207

• In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver.

  Journal of pharmaceutical sciences 20070201

• Possible interethnic differences in quinidine-induced QT prolongation between healthy Caucasian and Korean subjects.

  British journal of clinical pharmacology 20070201

• Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance.

  Drug metabolism and disposition: the biological fate of chemicals 20070201

• Primary culture of rat hepatocytes in 96-well plates: effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screening.

  Toxicology in vitro : an international journal published in association with BIBRA 20070201

• Crystal and molecular structures of trichloro-cobalt(II) complexes of epiquinine, epiquinidine, and epidihydrocinchonine.

  Chirality 20070201

• Saccharomyces cerevisiae multidrug resistance transporter Qdr2 is implicated in potassium uptake, providing a physiological advantage to quinidine-stressed cells.

  Eukaryotic cell 20070201

• Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers.

  European journal of clinical pharmacology 20070201

• A real reason for patients with pseudobulbar affect to smile.

  Annals of neurology 20070201

• Lack of inhibitory effects of several fluoroquinolones on cytochrome P-450 3A activities at clinical dosage in dogs.

  Journal of veterinary pharmacology and therapeutics 20070201

• Case 32-2006: a girl with fever after a visit to Africa.

  The New England journal of medicine 20070201

• Case 32-2006: a girl with fever after a visit to Africa.

  The New England journal of medicine 20070201

• Pharmacokinetics of quinine and its metabolites in pregnant Sudanese women with uncomplicated Plasmodium falciparum malaria.

  Journal of clinical pharmacy and therapeutics 20070201

• Sodium-activated potassium current in guinea pig gastric myocytes.

  Journal of Korean medical science 20070201

• Marketing and drug costs: who is laughing and crying?

  Annals of neurology 20070201

• Ionic basis of pharmacological therapy in Brugada syndrome.

  Journal of cardiovascular electrophysiology 20070201

• Identification of human cytochrome P450 enzymes involved in the major metabolic pathway of fluvoxamine.

  Xenobiotica; the fate of foreign compounds in biological systems 20070201

• Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death.

  Circulation 20070130

• Novel quinolizidinyl derivatives as antiarrhythmic agents.

  Journal of medicinal chemistry 20070125

• Simple-to-use, reference criteria for revealing drug-induced QT interval prolongation in conscious dogs.

  European journal of pharmacology 20070105

• Effect of transporters on the secretion of phytochemicals by the roots of Arabidopsis thaliana.

  Planta 20070101

• The effect of high extracellular potassium on IKr inhibition by anti-arrhythmic agents.

  Cardiology 20070101

• Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation.

  Drug metabolism and disposition: the biological fate of chemicals 20070101

• Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/Delta murine hearts modelling long QT syndrome 3.

  The Journal of physiology 20070101

• Differential contributions of Shaker and Shab K+ currents to neuronal firing patterns in Drosophila.

  Journal of neurophysiology 20070101

• Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine.

  Molecular microbiology 20070101

• CYP3A4 mediated in vitro metabolism of vinflunine in human liver microsomes.

  Acta pharmacologica Sinica 20070101

• Differences in arrhythmogenicity between the canine right ventricular outflow tract and anteroinferior right ventricle in a model of Brugada syndrome.

  Heart rhythm 20070101

• Overestimating resistance in field testing of malaria parasites: simple methods for estimating high EC50 values using a Bayesian approach.

  Malaria journal 20070101

• Mid-term follow-up of patients with Brugada syndrome following a cardioverter defibrillator implantation: a single center experience.

  Indian pacing and electrophysiology journal 20070101

• Cytotoxicity of chloroquine in isolated rat hepatocytes.

  Journal of applied toxicology : JAT 20070101

• Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heart.

  Acta physiologica (Oxford, England) 20070101

• A postsynaptic negative feedback mediated by coupling between AMPA receptors and Na+-activated K+ channels in spinal cord neurones.

  The European journal of neuroscience 20070101

• Quinine-induced arrhythmia in a patient with severe malaria.

  Acta medica Indonesiana 20070101

• Atrial, SA nodal, and AV nodal electrophysiology in standing horses: normal findings and electrophysiologic effects of quinidine and diltiazem.

  Journal of veterinary internal medicine 20070101

• Highly enantioselective epoxidation of 2-methylnaphthoquinone (vitamin K3) mediated by new cinchona alkaloid phase-transfer catalysts.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

• Application of chimeric mice with humanized liver for predictive ADME.

  Drug metabolism reviews 20070101

• Clinical review: aggressive management and extracorporeal support for drug-induced cardiotoxicity.

  Critical care (London, England) 20070101

• Biodiversity, traditional medicine and public health: where do they meet?

  Journal of ethnobiology and ethnomedicine 20070101

• The effects of quinidine and its chiral isolates on erg-1sm potassium current and correlation with gastrointestinal augmentation.

  American journal of therapeutics 20070101

• Acceptability and efficacy of intra-rectal quinine alkaloids as a pre-transfer treatment of non-per os malaria in peripheral health care facilities in Mopti, Mali.

  Malaria journal 20070101

• [Long QT syndrome induced by cordaron and quinidine].

  Klinicheskaia meditsina 20070101

• Approach to the asymptomatic patients with Brugada syndrome.

  Indian pacing and electrophysiology journal 20070101

• Effect of caffeine on quinidine transport to the central nervous system in rats.

  Journal of basic and clinical physiology and pharmacology 20070101

• Action potential experiments complete hERG assay and QT-interval measurements in cardiac preclinical studies.

  Journal of pharmacological and toxicological methods 20070101

• Echocardiographic evidence of left atrial mechanical dysfunction after conversion of atrial fibrillation to sinus rhythm in 5 horses.

  Journal of veterinary internal medicine 20070101

• Increased absorption of digoxin from the human jejunum due to inhibition of intestinal transporter-mediated efflux.

  Clinical pharmacokinetics 20070101

• [Atrial fibrillation].

  Archivos de cardiologia de Mexico 20070101

• Medicinal importance of grapefruit juice and its interaction with various drugs.

  Nutrition journal 20070101

• A man with tropical travel history, fever, and pulmonary infiltrates.

  Comprehensive therapy 20070101

• Myasthenia gravis.

  Orphanet journal of rare diseases 20070101

• Pilot feasibility study of an emergency paediatric kit for intra-rectal quinine administration used by the personnel of community-based health care units in Senegal.

  Malaria journal 20070101

• Antiarrhythmics: elimination and dosage considerations in hepatic impairment.

  Clinical pharmacokinetics 20070101

• A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response.

  PloS one 20070101

• Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes.

  European journal of drug metabolism and pharmacokinetics 20070101

• Impact of the changes in P-glycoprotein activity on domperidone pharmacokinetics in rat plasma.

  Pharmacological reports : PR 20070101

• Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes.

  European journal of drug metabolism and pharmacokinetics 20070101

• Competitive chemisorption between pairs of cinchona alkaloids and related compounds from solution onto platinum surfaces.

  Journal of the American Chemical Society 20061227

• P-Glycoprotein (P-gp) expressed in a confluent monolayer of hMDR1-MDCKII cells has more than one efflux pathway with cooperative binding sites.

  Biochemistry 20061226

• The connexin 36 blockers quinine, quinidine and mefloquine inhibit cortical spreading depression in a rat neocortical slice model in vitro.

  Brain research bulletin 20061211

• Evaluation of the state of active ingredients in pharmaceutical preparations using fourier transform-Raman difference spectra.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20061201

• Dextromethorphan/quinidine: a novel dextromethorphan product for the treatment of emotional lability.

  Expert opinion on pharmacotherapy 20061201

• Erythrocyte G protein as a novel target for malarial chemotherapy.

  PLoS medicine 20061201

• Atomoxetine: a novel treatment for child and adult ADHD.

  Neuropsychiatric disease and treatment 20061201

• Functional characterization of the brain-to-blood efflux clearance of human amyloid-beta peptide (1-40) across the rat blood-brain barrier.

  Neuroscience research 20061101

• Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney.

  Drug metabolism and disposition: the biological fate of chemicals 20061101

• Event-recorder monitoring in the diagnosis of atrial fibrillation in symptomatic patients: subanalysis of the SOPAT trial.

  Journal of cardiovascular electrophysiology 20061101

• Altering extracellular potassium concentration does not modulate drug block of human ether-a-go-go-related gene (hERG) channels.

  Clinical and experimental pharmacology & physiology 20061101

• Are one or two dangerous? Quinine and quinidine exposure in toddlers.

  The Journal of emergency medicine 20061101

• OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice.

  PLoS medicine 20061101

• Quinidine ceases electrical storm in an ablated patient with an implantable cardioverter-defibrillator: an old lady in the modern era.

  International journal of cardiology 20061026

• Case records of the Massachusetts General Hospital. Case 32-2006. A 3-year-old girl with fever after a visit to Africa.

  The New England journal of medicine 20061019

• Calculation of standard electrode potential of half reaction for benzoquinone and hydroquinone.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20061001

• Adaptive downregulation of a quinidine-sensitive cation conductance in renal principal cells of TWIK-1 knockout mice.

  Pflugers Archiv : European journal of physiology 20061001

• Comparison of permeation enhancing strategies for an oral factor Xa inhibitor using the Caco-2 cell monolayer model.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20061001

• Short QT syndrome: a case report and review of literature.

  Resuscitation 20061001

• Transport of timolol and tilisolol in rabbit corneal epithelium.

  Biological & pharmaceutical bulletin 20061001

• Induction of human P-glycoprotein in Caco-2 cells: development of a highly sensitive assay system for P-glycoprotein-mediated drug transport.

  Drug metabolism and pharmacokinetics 20061001

• Dextromethorphan and quinidine in adult patients with uncontrolled painful diabetic peripheral neuropathy: a 29-day, multicenter, open-label, dose-escalation study.

  Clinical therapeutics 20061001

• The complexity of intestinal absorption and exsorption of digoxin in rats.

  International journal of pharmaceutics 20060928

• [Drug-induced hypoglycemia].

  Nihon rinsho. Japanese journal of clinical medicine 20060928

• Use of a failing rabbit heart as a model to predict torsadogenicity.

  Toxicological sciences : an official journal of the Society of Toxicology 20060901

• Minimizing polymorphic metabolism in drug discovery: evaluation of the utility of in vitro methods for predicting pharmacokinetic consequences associated with CYP2D6 metabolism.

  Drug metabolism and disposition: the biological fate of chemicals 20060901

• Intestinal and hepatic metabolic activity of five cytochrome P450 enzymes: impact on prediction of first-pass metabolism.

  The Journal of pharmacology and experimental therapeutics 20060901

• Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome.

  Journal of molecular and cellular cardiology 20060901

• Activation of metabotropic glutamate receptors induces propagating network oscillations in the intact cerebral cortex of the newborn mouse.

  Neuropharmacology 20060901

• Pharmacological activation and inhibition of Slack (Slo2.2) channels.

  Neuropharmacology 20060901

• Metabolism and metabolic inhibition of gambogic acid in rat liver microsomes.

  Acta pharmacologica Sinica 20060901

• The pronociceptive effect of ondansetron in the setting of P-glycoprotein inhibition.

  Anesthesia and analgesia 20060901

• Metabolic and efflux properties of Caco-2 cells stably transfected with nuclear receptors.

  Pharmaceutical research 20060901

• The winged chariot and the iron cages.

  The Ulster medical journal 20060901

• Clinical oral doses of dexamethasone decreases intrinsic clearance of quinidine, a cytochrome P450 3A substrate in dogs.

  The Journal of veterinary medical science 20060901

• Preparation of surfactant-free nanoparticles of methacrylic acid copolymers used for film coating.

  AAPS PharmSciTech 20060901

• Membrane transporter proteins: a challenge for CNS drug development.

  Dialogues in clinical neuroscience 20060901

• Mechanisms, regulation and pathologic significance of Mg2+ efflux from erythrocytes.

  Magnesium research 20060901

• Binding of anti-prion agents to glycosaminoglycans: evidence from electronic absorption and circular dichroism spectroscopy.

  Biochemical and biophysical research communications 20060811

• A phase I dose-finding and pharmacokinetic study of subcutaneous semisynthetic homoharringtonine (ssHHT) in patients with advanced acute myeloid leukaemia.

  British journal of cancer 20060807

• Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.

  Journal of the American Society of Nephrology : JASN 20060801

• A clinical drug library screen identifies astemizole as an antimalarial agent.

  Nature chemical biology 20060801

• Induction of propranolol metabolism by Ginkgo biloba extract EGb 761 in rats.

  Current drug metabolism 20060801

• Characterization of hepatic drug-metabolizing activities of Bama miniature pigs (Sus scrofa domestica): comparison with human enzyme analogs.

  Comparative medicine 20060801

• Transient rhythmic network activity in the somatosensory cortex evoked by distributed input in vitro.

  Neuroscience 20060721

• Connexin-36 gap junctions mediate electrical coupling between ventral tegmental area GABA neurons.

  Synapse (New York, N.Y.) 20060701

• Expression, purification, and characterization of mouse CYP2d22.

  Drug metabolism and disposition: the biological fate of chemicals 20060701

• Quinine distribution in pregnant mice with Plasmodium berghei malaria.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060701

• Establishment and characterization of the transformants stably-expressing MDR1 derived from various animal species in LLC-PK1.

  Pharmaceutical research 20060701

• Efavirenz does not interact with the ABCB1 transporter at the blood-brain barrier.

  Pharmaceutical research 20060701

• Pharmacological strategies for overcoming multidrug resistance.

  Current drug targets 20060701

• The procerebrum is necessary for odor-aversion learning in the terrestrial slug Limax valentianus.

  Learning & memory (Cold Spring Harbor, N.Y.) 20060701

• Effect of therapeutic moderate hypothermia on multi-drug resistance protein 1-mediated transepithelial transport of drugs.

  Neurologia medico-chirurgica 20060701

• Pseudobulbar affect in multiple sclerosis: toward the development of innovative therapeutic strategies.

  Journal of the neurological sciences 20060615

• Distinct frequency-dependent regulation of nerve terminal excitability and synaptic transmission by IA and IK potassium channels revealed by Drosophila Shaker and Shab mutations.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060607

• Frequency of high-risk use of QT-prolonging medications.

  Pharmacoepidemiology and drug safety 20060601

• Effects of gap junction blockers on human neocortical synchronization.

  Neurobiology of disease 20060601

• Effect of benzo[a]pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer.

  Toxicology 20060601

• Pharmacological rescue of carnitine transport in primary carnitine deficiency.

  Human mutation 20060601

• Interactions of cardiac drugs.

  The Annals of pharmacotherapy 20060601

• Saturable absorptive transport of the hydrophilic organic cation ranitidine in Caco-2 cells: role of pH-dependent organic cation uptake system and P-glycoprotein.

  Pharmaceutical research 20060601

• Intestinal absorptive transport of the hydrophilic cation ranitidine: a kinetic modeling approach to elucidate the role of uptake and efflux transporters and paracellular vs. transcellular transport in Caco-2 cells.

  Pharmaceutical research 20060601

• Voriconazole in the management of nosocomial invasive fungal infections.

  Therapeutics and clinical risk management 20060601

• Localization of multidrug transporter substrates within model membranes.

  Biochemistry 20060516

• Sensing metal ions with DNA building blocks: fluorescent pyridobenzimidazole nucleosides.

  Journal of the American Chemical Society 20060510

• Influence of erythromycin on the pharmacokinetics of ximelagatran may involve inhibition of P-glycoprotein-mediated excretion.

  Drug metabolism and disposition: the biological fate of chemicals 20060501

• Oxidative metabolism of the alkaloid rutaecarpine by human cytochrome P450.

  Drug metabolism and disposition: the biological fate of chemicals 20060501

• Tetraethylammonium and nicotine transport by the Malpighian tubules of insects.

  Journal of insect physiology 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Metabolism and effect of para-toluene-sulfonamide on rat liver microsomal cytochrome P450 from in vivo and in vitro studies.

  Acta pharmacologica Sinica 20060501

• Randomized, controlled trial of dextromethorphan/quinidine for pseudobulbar affect in multiple sclerosis.

  Annals of neurology 20060501

• Monitoring of drugs with a narrow therapeutic range in ambulatory care.

  The American journal of managed care 20060501

• Torsades de pointes in congenital long QT syndrome following low-dose orphenadrine.

  International journal of clinical practice 20060501

• Effect of plantain on therapeutic drug monitoring of digoxin and thirteen other common drugs.

  Annals of clinical biochemistry 20060501

• Oxidative metabolism of 5-methoxy-N,N-diisopropyltryptamine (Foxy) by human liver microsomes and recombinant cytochrome P450 enzymes.

  Biochemical pharmacology 20060428

• Ciprofloxacin permeability and its active secretion through rat small intestine in vitro.

  International journal of pharmaceutics 20060426

• Antiarrhythmic drugs for maintaining sinus rhythm after cardioversion of atrial fibrillation: a systematic review of randomized controlled trials.

  Archives of internal medicine 20060410

• Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.

  Journal of medicinal chemistry 20060406

• The role of transporters in drug interactions.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060401

• Development, validation and utility of an in vitro technique for assessment of potential clinical drug-drug interactions involving P-glycoprotein.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060401

• Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction.

  Drug metabolism and disposition: the biological fate of chemicals 20060401

• Modulation of P-glycoprotein-mediated efflux by prodrug derivatization: an approach involving peptide transporter-mediated influx across rabbit cornea.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20060401

• [Short QT Syndromes].

  Herz 20060401

• [Malaria: report of 12 non autochthonous cases].

  Revista medica de Chile 20060401

• Characterization of the cytochrome P450 enzymes and enzyme kinetic parameters for metabolism of BVT.2938 using different in vitro systems.

  Journal of pharmaceutical and biomedical analysis 20060318

• Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A.

  American journal of physiology. Regulatory, integrative and comparative physiology 20060301

• Selectivity of substrate (trifluoperazine) and inhibitor (amitriptyline, androsterone, canrenoic acid, hecogenin, phenylbutazone, quinidine, quinine, and sulfinpyrazone) 'probes' for human udp-glucuronosyltransferases.

  Drug metabolism and disposition: the biological fate of chemicals 20060301

• Alpha 1-acid glycoprotein reverses cocaine-induced sodium channel blockade in cardiac myocytes.

  Toxicology 20060301

• Pharmacokinetic analysis of transcellular transport of quinidine across monolayers of human intestinal epithelial Caco-2 cells.

  Biological & pharmaceutical bulletin 20060301

• Determination of p-glycoprotein ATPase activity using luciferase.

  Biological & pharmaceutical bulletin 20060301

• Drug therapy of paroxysmal atrial fibrillation in the elderly over 75 years old.

  Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20060301

• Effects of low-dose quinidine on ventricular tachyarrhythmias in patients with Brugada syndrome: low-dose quinidine therapy as an adjunctive treatment.

  Journal of cardiovascular pharmacology 20060301

• The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model.

  Journal of ethnopharmacology 20060220

• An increase in late sodium current potentiates the proarrhythmic activities of low-risk QT-prolonging drugs in female rabbit hearts.

  The Journal of pharmacology and experimental therapeutics 20060201

• Two-pore-domain potassium channels support anion secretion from human airway Calu-3 epithelial cells.

  Pflugers Archiv : European journal of physiology 20060201

• Territrems B and C metabolism in human liver microsomes: major role of CYP3A4 and CYP3A5.

  Toxicology 20060201

• A 21-year-old woman from Africa with fever, anemia, and jaundice 7 days after arriving in the US.

  Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association 20060201

• Prediction of drug-drug interactions for AUCoral of high clearance drug from in vitro data: utilization of a microtiter plate assay and a dispersion model.

  Current drug metabolism 20060201

• A hundred years of cascading - started by Paul Morawitz (1879-1936), a pioneer of haemostasis and of transfusion.

  Transfusion medicine (Oxford, England) 20060201

• Brugada syndrome and vasovagal syncope.

  Pacing and clinical electrophysiology : PACE 20060201

• Application of solid-phase microextraction in the investigation of protein binding of pharmaceuticals.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060118

• Development of an on-line extraction turbulent flow chromatography tandem mass spectrometry method for cassette analysis of Caco-2 cell based bi-directional assay samples.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060118

• Long QT syndrome: reduced repolarization reserve and the genetic link.

  Journal of internal medicine 20060101

• Interaction of the mitotic kinesin Eg5 inhibitor monastrol with P-glycoprotein.

  Naunyn-Schmiedeberg's archives of pharmacology 20060101

• Characterization of brimonidine transport in retinal pigment epithelium.

  Investigative ophthalmology & visual science 20060101

• Elimination of late potentials by quinidine in a patient with Brugada syndrome.

  Journal of electrocardiology 20060101

• Thirty years on quinidine for paroxysmal ventricular tachycardia.

  Journal of the Royal Society of Medicine 20060101

• The impact of CYP2C8 polymorphism and grapefruit juice on the pharmacokinetics of repaglinide.

  British journal of clinical pharmacology 20060101

• Increased risk of paroxysmal atrial fibrillation episodes associated with acute increases in ambient air pollution.

  Environmental health perspectives 20060101

• Monomorphic ventricular tachycardia due to Brugada syndrome successfully treated by hydroquinidine therapy in a 3-year-old child.

  Journal of cardiovascular electrophysiology 20060101

• Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.

  Malaria journal 20060101

• Drug-induced QT prolongation: an update.

  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20060101

• St. John's wort does not interfere with therapeutic drug monitoring of 12 commonly monitored drugs using immunoassays.

  Journal of clinical laboratory analysis 20060101

• Development and characterization of LLC-PK1 cells containing Sprague-Dawley rat Abcb1a (Mdr1a): comparison of rat P-glycoprotein transport to human and mouse.

  Journal of pharmacological and toxicological methods 20060101

• Proarrhythmia.

  Handbook of experimental pharmacology 20060101

• Therapy for the Brugada syndrome.

  Handbook of experimental pharmacology 20060101

• Evaluation of solid-phase sorbents for the analysis of ropinirole in whole blood.

  Journal of analytical toxicology 20060101

• Assessing the properties of internal standards for quantitative matrix-assisted laser desorption/ionization mass spectrometry of small molecules.

  Rapid communications in mass spectrometry : RCM 20060101

• Effects of cardioactive medications on retrograde conduction: continuing relevance for current devices.

  Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20060101

• Efflux mechanism of taurocholate across the rat intestinal basolateral membrane.

  Molecular pharmaceutics 20060101

• Serum cystatin C levels to predict serum concentration of digoxin in Japanese patients.

  International journal of medical sciences 20060101

• In vitro studies on quetiapine metabolism using the substrate depletion approach with focus on drug-drug interactions.

  Drug metabolism and drug interactions 20060101

• Potassium channel gene mutations rarely cause atrial fibrillation.

  BMC medical genetics 20060101

• Potential interactions of methylphenidate and atomoxetine with dextromethorphan.

  Journal of the American Pharmacists Association : JAPhA 20060101

• Liquid chromatographic analysis of cinchona alkaloids in beverages.

  Journal of AOAC International 20060101

• Brugada syndrome.

  Orphanet journal of rare diseases 20060101

• Prediction of in vivo drug-drug interactions from in vitro data : factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4.

  Clinical pharmacokinetics 20060101

• Pulmonary manifestations of malaria : recognition and management.

  Treatments in respiratory medicine 20060101

• An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics.

  Toxicology 20051215

• Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3).

  The Journal of pharmacology and experimental therapeutics 20051201

• Comparison of P-glycoprotein-mediated drug-digoxin interactions in Caco-2 with human and rodent intestine: relevance to in vivo prediction.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20051201

• pH-dependent functional activity of P-glycoprotein in limiting intestinal absorption of protic drugs: kinetic analysis of quinidine efflux in situ.

  Journal of pharmaceutical sciences 20051201

• Validation of an electrometric blood cholinesterase measurement in goats.

  Journal of veterinary science 20051201

• Carnitine/organic cation transporter OCTN2-mediated transport of carnitine in primary-cultured epididymal epithelial cells.

  Reproduction (Cambridge, England) 20051201

• Effects of inhibitors of nonselective cation channels on the acetylcholine-induced depolarization of circular smooth muscle from the guinea-pig stomach antrum.

  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20051201

• Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality.

  Therapeutics and clinical risk management 20051201

• Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

  The Journal of biological chemistry 20051118

• [Atrial flutter and fibrillation].

  Praxis 20051109

• Interaction of organic cations with a newly identified plasma membrane monoamine transporter.

  Molecular pharmacology 20051101

• Pre-equilibrium capillary zone electrophoresis or frontal analysis: advantages of plateau peak conditions in affinity capillary electrophoresis.

  Electrophoresis 20051101

• Tyrosine and tyramine increase endogenous ganglionic morphine and dopamine levels in vitro and in vivo: cyp2d6 and tyrosine hydroxylase modulation demonstrates a dopamine coupling.

  Medical science monitor : international medical journal of experimental and clinical research 20051101

• How to perform transvenous electrical cardioversion in horses with atrial fibrillation.

  Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 20051101

• Chromatographic separation of phenylpropanol enantiomers on a quinidine carbamate-type chiral stationary phase.

  Journal of chromatography. A 20051014

• Chromatographic behavior of the enantiomers of 2,2,2-trifluoro-1-(9-anthryl)ethanol on a quinidine-carbamate chiral stationary phase.

  Journal of chromatography. A 20051014

• New drug salt formation in biodegradable microspheres.

  International journal of pharmaceutics 20051013

• Dopamine modulation of two delayed rectifier potassium currents in a small neural network.

  Journal of neurophysiology 20051001

• Quinidine and procainamide inhibit murine macrophage uptake of apoptotic and necrotic cells: a novel contributing mechanism of drug-induced-lupus.

  Apoptosis : an international journal on programmed cell death 20051001

• Effects of dietary or injected organic cations on larval Drosophila melanogaster: mortality and elimination of tetraethylammonium from the hemolymph.

  Archives of insect biochemistry and physiology 20051001

• The steady-state Michaelis-Menten analysis of P-glycoprotein mediated transport through a confluent cell monolayer cannot predict the correct Michaelis constant Km.

  Pharmaceutical research 20051001

• Short QT interval syndrome: a case report.

  Journal of electrocardiology 20051001

• Short QT syndrome. Genotype-phenotype correlations.

  Journal of electrocardiology 20051001

• Drug therapy in Brugada syndrome.

  Current drug targets. Cardiovascular & haematological disorders 20051001

• Treatment of an ocular squamous cell carcinoma in a stallion with atrial fibrillation.

  The Canadian veterinary journal = La revue veterinaire canadienne 20051001

• Inducibility of abnormal automaticity and triggered activity in myocardial sleeves of canine pulmonary veins.

  International journal of cardiology 20050915

• Effects of quinine, quinidine, and chloroquine on alpha9alpha10 nicotinic cholinergic receptors.

  Molecular pharmacology 20050901

• Molecular and functional characterization of an Na+-independent choline transporter in rat astrocytes.

  Journal of neurochemistry 20050901

• Electrophysiological basis and genetics of Brugada syndrome.

  Journal of cardiovascular electrophysiology 20050901

• Blood schizontocidal activity of azithromycin and its combination with alpha/beta arteether against multi-drug resistant Plasmodium yoelii nigeriensis, a novel MDR parasite model for antimalarial screening.

  Parasitology 20050901

• Catalytic asymmetric desymmetrization of cyclic meso-1,3- and 1,4-diols by a phosphinite derivative of quinidine.

  Organic letters 20050818

• Short QT syndrome.

  Cardiovascular research 20050815

• Interactions of mefloquine with ABC proteins, MRP1 (ABCC1) and MRP4 (ABCC4) that are present in human red cell membranes.

  Biochemical pharmacology 20050815

• Regulatory and necrotic volume increase in boar spermatozoa.

  Journal of cellular physiology 20050801

• Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20050801

• Substrate specific metabolism by polymorphic cytochrome P450 2D6 alleles.

  Toxicology in vitro : an international journal published in association with BIBRA 20050801

• Quinidine plus verapamil vs. quinidine alone to prevent recurrences of atrial fibrillation.

  European heart journal 20050801

• Prediction of in vivo intestinal absorption enhancement on P-glycoprotein inhibition, from rat in situ permeability.

  Journal of pharmaceutical sciences 20050801

• Human cardiac potassium channel DNA polymorphism modulates access to drug-binding site and causes drug resistance.

  The Journal of clinical investigation 20050801

• Studies of the inhibition of serum pseudocholinesterase activity in vitro by commonly used drugs.

  American journal of clinical pathology 20050801

• pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum.

  Molecular microbiology 20050801

• Arrhythmic storm responsive to quinidine in a patient with Brugada syndrome and vasovagal syncope.

  Pacing and clinical electrophysiology : PACE 20050801

• Practical application of guinea pig telemetry system for QT evaluation.

  The Journal of toxicological sciences 20050801

• Pharmacologic prophylaxis: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery.

  Chest 20050801

• Selective cleavage of AChR cRNAs harbouring mutations underlying the slow channel myasthenic syndrome by hammerhead ribozymes.

  Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research 20050801

• [3H]linopirdine binding to rat brain membranes is not relevant for M-channel interaction.

  European journal of pharmacology 20050725

• Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT.

  The Journal of biological chemistry 20050708

• CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions.

  The Journal of pharmacology and experimental therapeutics 20050701

• Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.

  Journal of pharmaceutical sciences 20050701

• Quinoline antimalarials decrease the rate of beta-hematin formation.

  Journal of inorganic biochemistry 20050701

• [PAFAC Study. Secondary prevention of atrial fibrillation after cardioversion].

  Der Internist 20050701

• Localization and differential activity of P-glycoprotein in the bovine olfactory and nasal respiratory mucosae.

  Pharmaceutical research 20050701

• Brief review of the recently described short QT syndrome and other cardiac channelopathies.

  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20050701

• Rate-limiting biotransformation of triamterene is mediated by CYP1A2.

  International journal of clinical pharmacology and therapeutics 20050701

• Clinical characteristics and treatment of short QT syndrome.

  Expert review of cardiovascular therapy 20050701

• [Definition and mechanism of drug-induced thrombocytopenia].

  Rinsho byori. The Japanese journal of clinical pathology 20050701

• Successful treatment of electrical storm with oral quinidine in Brugada syndrome.

  Italian heart journal : official journal of the Italian Federation of Cardiology 20050701

• Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors.

  Journal of medicinal chemistry 20050602

• The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist.

  Journal of clinical pharmacology 20050601

• Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillators.

  Environmental health perspectives 20050601

• Ventricular tachycardia induced by biventricular pacing in patient with severe ischemic cardiomyopathy.

  Journal of cardiovascular electrophysiology 20050601

• Suppression of electrical storm by oral quinidine in a patient with Brugada syndrome.

  Journal of cardiovascular electrophysiology 20050601

• Confirmation of the structure of (3S)-3-hydroxyquinine: synthesis and X-ray crystal structure of its 9-aceto analogue.

  Journal of natural products 20050601

• Evaluation of dextromethorphan metabolism using hepatocytes from CYP2D6 poor and extensive metabolizers.

  Drug metabolism and pharmacokinetics 20050601

• Transcellular transport of creatinine in renal tubular epithelial cell line LLC-PK1.

  Drug metabolism and pharmacokinetics 20050601

• Class I antiarrhythmics inhibit Na+ absorption and Cl- secretion in rabbit descending colon epithelium.

  Naunyn-Schmiedeberg's archives of pharmacology 20050601

• Usefulness of hepatocytes for evaluating the genetic polymorphism of CYP2D6 substrates.

  Xenobiotica; the fate of foreign compounds in biological systems 20050601

• Identification of cytochrome P450 forms involved in the 4-hydroxylation of valsartan, a potent and specific angiotensin II receptor antagonist, in human liver microsomes.

  Xenobiotica; the fate of foreign compounds in biological systems 20050601

• Expert Canadian consensus suggestions on the rational, clinical use of ziprasidone in the treatment of schizophrenia and related psychotic disorders.

  Neuropsychiatric disease and treatment 20050601

• Treatment of pseudobulbar affect in ALS: October 26 highlight and commentary.

  Neurology 20050524

• Efficient synthesis of an imidazole-substituted delta-amino acid by the integration of chiral technologies.

  Organic letters 20050512

• Measurement of unbound ranitidine in blood and bile of anesthetized rats using microdialysis coupled to liquid chromatography and its pharmacokinetic application.

  Journal of chromatography. A 20050506

• Hepatic uptake of the novel antifungal agent caspofungin.

  Drug metabolism and disposition: the biological fate of chemicals 20050501

• Quinidine cardiotoxicity.

  The Journal of emergency medicine 20050501

• Chlorpropamide 2-hydroxylation is catalysed by CYP2C9 and CYP2C19 in vitro: chlorpropamide disposition is influenced by CYP2C9, but not by CYP2C19 genetic polymorphism.

  British journal of clinical pharmacology 20050501

• Treatment of pseudobulbar affect in ALS.

  The Lancet. Neurology 20050501

• Variable electrocardiographic effects of short-term quinidine sulfate administration in Brugada syndrome.

  Pacing and clinical electrophysiology : PACE 20050501

• QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone.

  Pacing and clinical electrophysiology : PACE 20050501

• A novel missense mutation in the SCN5A gene associated with Brugada syndrome bidirectionally affecting blocking actions of antiarrhythmic drugs.

  Journal of cardiovascular electrophysiology 20050501

• Catalytic enantioselective sulfinyl transfer using cinchona alkaloid catalysts.

  Organic letters 20050428

• Development and characterization of an immobilized human organic cation transporter based liquid chromatographic stationary phase.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050425

• New general sulfinylating process for asymmetric synthesis of enantiopure sulfinates and sulfoxides.

  Organic letters 20050414

• Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.

  Drug metabolism and disposition: the biological fate of chemicals 20050401

• Characterization of chromanol 293B-induced block of the delayed-rectifier K+ current in heart-derived H9c2 cells.

  Life sciences 20050401

• A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes.

  Journal of pharmaceutical and biomedical analysis 20050401

• Development of oxygen sensing in the gills of zebrafish.

  The Journal of experimental biology 20050401

• [Effects of quinidine on pinacidil-induced transmural dispersion of repolarization in canine right ventricular wall].

  Zhonghua xin xue guan bing za zhi 20050401

• Do naïve ruminants degrade alkaloids in the rumen?

  Journal of chemical ecology 20050401

• 25th anniversary of the International Long-QT Syndrome Registry: an ongoing quest to uncover the secrets of long-QT syndrome.

  Circulation 20050308

• Predictive models of CYP3A4 Heteroactivation: in vitro-in vivo scaling and pharmacophore modeling.

  The Journal of pharmacology and experimental therapeutics 20050301

• Assessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20050301

• Characterization of human cytochrome P450 enzymes involved in the in vitro metabolism of perospirone.

  Biopharmaceutics & drug disposition 20050301

• Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: implications on nose-to-brain transport.

  Journal of pharmaceutical sciences 20050301

• High-throughput solution-based medicinal library screening against human serum albumin.

  Analytical chemistry 20050301

• Polymorphism screening in the cardiac K+ channel gene KCNA5.

  Clinical pharmacology and therapeutics 20050301

• [Drug induced uveitis].

  Archivos de la Sociedad Espanola de Oftalmologia 20050301

• The influence of extracellular acidosis on the effect of IKr blockers.

  Journal of cardiovascular pharmacology and therapeutics 20050301

• Electrical activity alterations induced by chronic absorption of lindane (gamma-hexachlorocyclohexane) trace concentrations in adult rat heart.

  Canadian journal of physiology and pharmacology 20050301

• Mechanisms underlying regulation of a barium-sensitive K+ conductance by ATP in single proximal tubule cells isolated from frog kidney.

  The Journal of membrane biology 20050301

• Identification of cytochrome P450 enzymes involved in the metabolism of 3',4'-methylenedioxy-alpha-pyrrolidinopropiophenone (MDPPP), a designer drug, in human liver microsomes.

  Xenobiotica; the fate of foreign compounds in biological systems 20050301

• Pre-clinical assessment of DRF 4367, a novel COX-2 inhibitor: evaluation of pharmacokinetics, absolute oral bioavailability and metabolism in mice and comparative inter-species in vitro metabolism.

  Xenobiotica; the fate of foreign compounds in biological systems 20050301

• Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4.

  Therapeutics and clinical risk management 20050301

• pH-dependent functional activity of P-glycoprotein in limiting intestinal absorption of protic drugs 1. Simultaneous determination of quinidine and permeability markers in rat in situ perfusion samples.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050225

• The yeast multidrug transporter Qdr3 (Ybr043c): localization and role as a determinant of resistance to quinidine, barban, cisplatin, and bleomycin.

  Biochemical and biophysical research communications 20050218

• A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system.

  Toxicological sciences : an official journal of the Society of Toxicology 20050201

• Cyp2D6 catalyzes 5-hydroxylation of 1-(2-pyrimidinyl)-piperazine, an active metabolite of several psychoactive drugs, in human liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20050201

• Cobalt complexes with cinchonidine and quinidine: effect of C8/C9 stereochemistry and 6'-substitution on intermolecular interactions.

  Chirality 20050201

• Treatment of emotional lability in ALS.

  The Lancet. Neurology 20050201

• When should we discontinue antiarrhythmic therapy for atrial fibrillation after coronary artery bypass grafting? A prospective randomized study.

  The Journal of thoracic and cardiovascular surgery 20050201

• Cutaneous hyperpigmentation due to chronic quinine ingestion.

  Cutis 20050201

• Metformin transport by renal basolateral organic cation transporter hOCT2.

  Pharmaceutical research 20050201

• Characterization of a hERG screen using the IonWorks HT: comparison to a hERG rubidium efflux screen.

  Assay and drug development technologies 20050201

• Genetic susceptibility to acquired long QT syndrome: pharmacologic challenge in first-degree relatives.

  Heart rhythm 20050201

• Brugada syndrome--an update.

  Chang Gung medical journal 20050201

• Highly enantioselective amination of alpha-substituted alpha-cyanoacetates with chiral catalysts accessible from both quinine and quinidine.

  Organic letters 20050120

• Role of the solvent in the adsorption-desorption equilibrium of cinchona alkaloids between solution and a platinum surface: correlations among solvent polarity, cinchona solubility, and catalytic performance.

  The journal of physical chemistry. B 20050113

• Up-regulation of P-glycoprotein expression in small intestine under chronic serotonin-depleted conditions in rats.

  The Journal of pharmacology and experimental therapeutics 20050101

• The elementary mass action rate constants of P-gp transport for a confluent monolayer of MDCKII-hMDR1 cells.

  Biophysical journal 20050101

• The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model.

  Drug metabolism and disposition: the biological fate of chemicals 20050101

• Nitromusk and polycyclic musk compounds as long-term inhibitors of cellular xenobiotic defense systems mediated by multidrug transporters.

  Environmental health perspectives 20050101

• Recurrent cardiac events in patients with idiopathic ventricular fibrillation, excluding patients with the Brugada syndrome.

  BMC medicine 20050101

• Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG.

  Journal of cardiovascular electrophysiology 20050101

• Potent CYP3A4 inhibitory constituents of Piper cubeba.

  Journal of natural products 20050101

• Science review: The use of proton pump inhibitors for gastric acid suppression in critical illness.

  Critical care (London, England) 20050101

• Block of NA+ and K+ currents in rat ventricular myocytes by quinacainol and quinidine.

  Clinical and experimental pharmacology & physiology 20050101

• Cytochrome P450-dependent metabolism of gefitinib.

  Xenobiotica; the fate of foreign compounds in biological systems 20050101

• [Atrial fibrillation: choice of the method of pharmacological cardioversion].

  Kardiologiia 20050101

• [Algid malaria].

  Meditsinskaia parazitologiia i parazitarnye bolezni 20050101

• Microarray karyotyping of commercial wine yeast strains reveals shared, as well as unique, genomic signatures.

  BMC genomics 20050101

• In vivo evidence for the efflux transport of pentazocine from the brain across the blood-brain barrier using the brain efflux index method.

  Journal of drug targeting 20050101

• Dextromethorphan/quinidine: AVP 923, dextromethorphan/cytochrome P450-2D6 inhibitor, quinidine/dextromethorphan.

  Drugs in R&D 20050101

• Specific therapy based on the genotype and cellular mechanism in inherited cardiac arrhythmias. Long QT syndrome and Brugada syndrome.

  Current pharmaceutical design 20050101

• Gender and its effect in cardiovascular pharmacotherapeutics: recent considerations.

  Congestive heart failure (Greenwich, Conn.) 20050101

• Some fundamental and technical aspects of the quantitative analysis of pharmaceutical drugs by matrix-assisted laser desorption/ionization mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20050101

• Transport of thalidomide by the human intestinal caco-2 monolayers.

  European journal of drug metabolism and pharmacokinetics 20050101

• A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a-go-go-related gene (HERG) channels.

  American journal of therapeutics 20050101

• Assessing observational studies of medical treatments.

  Emerging themes in epidemiology 20050101

• ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal.

  Cancer cell international 20050101

• Editorial: Atrial fibrillation in horses: new treatment choices for the new millennium?

  Journal of veterinary internal medicine 20050101

• Transvenous electrical cardioversion of equine atrial fibrillation: technical considerations.

  Journal of veterinary internal medicine 20050101

• Therapeutic options for emotional lability: current and emerging treatments.

  The American journal of geriatric pharmacotherapy 20050101

• Review of pseudobulbar affect including a novel and potential therapy.

  The Journal of neuropsychiatry and clinical neurosciences 20050101

• Identification of enzymes involved in phase I metabolism of ciclesonide by human liver microsomes.

  European journal of drug metabolism and pharmacokinetics 20050101

• QT PRODACT: in vivo QT assay in the conscious dog for assessing the potential for QT interval prolongation by human pharmaceuticals.

  Journal of pharmacological sciences 20050101

• Congenital short QT syndrome. A review.

  Romanian journal of internal medicine = Revue roumaine de medecine interne 20050101

• Rate-control or rhythm-control: where do we stand?

  Indian pacing and electrophysiology journal 20050101

• Electrical storms in Brugada syndrome: review of pharmacologic and ablative therapeutic options.

  Indian pacing and electrophysiology journal 20050101

• [Character of patients with paroxysmal atrial fibrillation].

  Folia medica Cracoviensia 20050101

• Evidence for a substrate specific and inhibitable drug efflux system in chloroquine resistant Plasmodium falciparum strains.

  Biochemistry 20041228

• Reconstitution of the basal calcium transport in resealed human red blood cell ghosts.

  Biochemical and biophysical research communications 20041224

• In vitro and ex vivo evidence for modulation of P-glycoprotein activity by progestins.

  Biochemical pharmacology 20041215

• Structure of the amodiaquine-FPIX mu oxo dimer solution complex at atomic resolution.

  Inorganic chemistry 20041213

• Adsorption of the enantiomers of 2,2,2-trifluoro-1-(9-anthryl)-ethanol on silica-bonded chiral quinidine-carbamate.

  Journal of chromatography. A 20041203

• Utility of recombinant enzyme kinetics in prediction of human clearance: impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates.

  Drug metabolism and disposition: the biological fate of chemicals 20041201

• Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism.

  Biochemical pharmacology 20041201

• Probenecid interacts with the pharmacokinetics of morphine-6-glucuronide in humans.

  Anesthesiology 20041201

• The vascular and cardioprotective effects of liriodenine in ischemia-reperfusion injury via NO-dependent pathway.

  Nitric oxide : biology and chemistry 20041201

• Effect of various cytochrome P450 3A and P-glycoprotein modulators on the biliary clearance of bromosulphaphthalein in male wistar rats.

  Die Pharmazie 20041201

• The effect of a series of organic cations upon the plasmalemmal serotonin transporter, SERT.

  Life sciences 20041119

• Impairment of olfactory discrimination by blockade of nitric oxide activity in the terrestrial slug Limax valentianus.

  Neuroscience letters 20041111

• Effects of uremic toxins on hepatic uptake and metabolism of erythromycin.

  Drug metabolism and disposition: the biological fate of chemicals 20041101

• Mechanism-based inactivation of CYP2D6 by methylenedioxymethamphetamine.

  Drug metabolism and disposition: the biological fate of chemicals 20041101

• Neuroepithelial oxygen chemoreceptors of the zebrafish gill.

  The Journal of physiology 20041101

• Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell model.

  Biochemical pharmacology 20041101

• Pharmacokinetics of baicalin in rats and its interactions with cyclosporin A, quinidine and SKF-525A: a microdialysis study.

  Planta medica 20041101

• Susceptibility of Leptospira serovars to antimalarial agents.

  The American journal of tropical medicine and hygiene 20041101

• Use of intravenous flecainide in horses with naturally-occurring atrial fibrillation.

  Equine veterinary journal 20041101

• [Mechanism of mono-hydroxylation of daidzein in human liver microsomes].

  Yao xue xue bao = Acta pharmaceutica Sinica 20041101

• Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: a randomized trial.

  Neurology 20041026

• Malaria-related deaths among U.S. travelers, 1963-2001.

  Annals of internal medicine 20041005

• Effect of quinidine on the 10-hydroxylation of R-warfarin: species differences and clearance projection.

  The Journal of pharmacology and experimental therapeutics 20041001

• Ethanol suppression of ventral tegmental area GABA neuron electrical transmission involves N-methyl-D-aspartate receptors.

  The Journal of pharmacology and experimental therapeutics 20041001

• Pharmacokinetics of erythromycin in rabbit corneas after single-dose infusion: role of P-glycoprotein as a barrier to in vivo ocular drug absorption.

  The Journal of pharmacology and experimental therapeutics 20041001

• Pharmacokinetics of dextromethorphan after single or multiple dosing in combination with quinidine in extensive and poor metabolizers.

  Journal of clinical pharmacology 20041001

• Five new alkaloids from the leaves of Remijia peruviana.

  Journal of natural products 20041001

• Multiple oral dosing of ketoconazole influences pharmacokinetics of quinidine after intravenous and oral administration in beagle dogs.

  Journal of veterinary pharmacology and therapeutics 20041001

• Automated tight seal electrophysiology for assessing the potential hERG liability of pharmaceutical compounds.

  Assay and drug development technologies 20041001

• QT-screen: high-throughput cardiac safety pharmacology by extracellular electrophysiology on primary cardiac myocytes.

  Assay and drug development technologies 20041001

• Efficacy of quinidine in high-risk patients with Brugada syndrome.

  Circulation 20040928

• Limitations to antiarrhythmic drug use in patients with atrial fibrillation.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20040928

• Human organic cation transporter 3 mediates the transport of antiarrhythmic drugs.

  European journal of pharmacology 20040919

• Acid-sensitive two-pore domain potassium (K2P) channels in mouse taste buds.

  Journal of neurophysiology 20040901

• Fenproporex N-dealkylation to amphetamine--enantioselective in vitro studies in human liver microsomes as well as enantioselective in vivo studies in Wistar and Dark Agouti rats.

  Biochemical pharmacology 20040901

• Evidence for a novel K(+) channel modulated by alpha(1A)-adrenoceptors in cardiac myocytes.

  Molecular pharmacology 20040901

• The sensitivities of yeast strains deficient in PDR ABC transporters, to quinoline-ring antimalarial drugs.

  Annals of tropical medicine and parasitology 20040901

• Quinidine-induced gastric ulcer.

  Gastrointestinal endoscopy 20040901

• A 25-year control of idiopathic ventricular fibrillation with electrophysiologic-guided antiarrhythmic drug therapy.

  Heart rhythm 20040901

• Drug-drug interactions of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338.

  European journal of pharmacology 20040823

• Highly enantioselective conjugate addition of malonate and beta-ketoester to nitroalkenes: asymmetric C-C bond formation with new bifunctional organic catalysts based on cinchona alkaloids.

  Journal of the American Chemical Society 20040818

• Defining determinant molecular properties for the blockade of the apamin-sensitive SKCa channel in guinea-pig hepatocytes: the influence of polarizability and molecular geometry.

  Bioorganic & medicinal chemistry letters 20040802

• Exact kinetic analysis of passive transport across a polarized confluent MDCK cell monolayer modeled as a single barrier.

  Journal of pharmaceutical sciences 20040801

• Prevention of atrial fibrillation after cardioversion: results of the PAFAC trial.

  European heart journal 20040801

• Quinidine rehabilitated and more lessons from the PAFAC and SOPAT anti-arrhythmic drug trials for the prevention of paroxysmal atrial fibrillation.

  European heart journal 20040801

• Suppression of paroxysmal atrial tachyarrhythmias--results of the SOPAT trial.

  European heart journal 20040801

• In situ transport of vinblastine and selected P-glycoprotein substrates: implications for drug-drug interactions at the mouse blood-brain barrier.

  Pharmaceutical research 20040801

• ABC transporter inhibitors that are substrates enhance lentiviral vector transduction into primitive hematopoietic progenitor cells.

  Blood 20040715

• An apical K(+)-dependent HCO(3)- transport pathway opposes transepithelial HCO(3)- absorption in rat medullary thick ascending limb.

  American journal of physiology. Renal physiology 20040701

• Delayed shrinkage triggered by the Na+-K+ pump in terbutaline-stimulated rat alveolar type II cells.

  Experimental physiology 20040701

• Cloning and functional expression of a novel marmoset cytochrome P450 2D enzyme, CYP2D30: comparison with the known marmoset CYP2D19.

  Biochemical pharmacology 20040701

• Torsade de pointes: the clinical considerations.

  International journal of cardiology 20040701

• Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy volunteers.

  Clinical pharmacology and therapeutics 20040701

• Inhibitory effect of lamotrigine on A-type potassium current in hippocampal neuron-derived H19-7 cells.

  Epilepsia 20040701

• Sesquiterpenes and flavonol glycosides from Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activities.

  Journal of natural products 20040701

• Comparison of kinetic properties of quinidine and dofetilide block of HERG channels.

  European journal of pharmacology 20040616

• ET-1 inhibits B-16 murine melanoma cell migration by decreasing K(+) currents.

  Cell motility and the cytoskeleton 20040601

• Validated assays for human cytochrome P450 activities.

  Drug metabolism and disposition: the biological fate of chemicals 20040601

• Involvement of P-glycoprotein in blood-brain barrier transport of pentazocine in rats using brain uptake index method.

  Biological & pharmaceutical bulletin 20040601

• Successful use of quinidine in treatment of electrical storm in Brugada syndrome.

  Pacing and clinical electrophysiology : PACE 20040601

• Travell trigger points--molecular and osteopathic perspectives.

  The Journal of the American Osteopathic Association 20040601

• Hydroquinidine therapy in Brugada syndrome.

  Journal of the American College of Cardiology 20040519

• Membrane-delimited regulation of novel background K+ channels by MgATP in murine immature B cells.

  The Journal of biological chemistry 20040514

• [Treatment of atrial fibrillation in a Hungarian hospital department of cardiologic internal medicine at the turn of the millennium].

  Orvosi hetilap 20040509

• The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone.

  British journal of clinical pharmacology 20040501

• Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier.

  Drug metabolism and disposition: the biological fate of chemicals 20040501

• Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents.

  Molecular pharmacology 20040501

• Acidification alters antiarrhythmic drug blockade of the ether-a-go-go-related Gene (HERG) Channels.

  Basic & clinical pharmacology & toxicology 20040501

• Inactivation gating determines drug potency: a common mechanism for drug blockade of HERG channels.

  Acta pharmacologica Sinica 20040501

• Organic cation transport by Malpighian tubules of Drosophila melanogaster: application of two novel electrophysiological methods.

  The Journal of experimental biology 20040501

• Maternal arrhythmias during pregnancy.

  Archives of gynecology and obstetrics 20040501

• Comparison of systolic cardiac function before and after treatment of atrial fibrillation in horses with and without additional cardiac valve insufficiencies.

  Veterinary research communications 20040501

• Emerging drug--resistance and guidelines for treatment of malaria.

  Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20040501

• Influence of different recombinant systems on the cooperativity exhibited by cytochrome P4503A4.

  Xenobiotica; the fate of foreign compounds in biological systems 20040501

• Short QT syndrome: pharmacological treatment.

  Journal of the American College of Cardiology 20040421

• Inactivation and recovery in Kv1.4 K+ channels: lipophilic interactions at the intracellular mouth of the pore.

  The Journal of physiology 20040401

• A voltage-gated K(+) current in renal inner medullary collecting duct cells.

  American journal of physiology. Cell physiology 20040401

• A trafficking defective, Brugada syndrome-causing SCN5A mutation rescued by drugs.

  Cardiovascular research 20040401

• Rifampicin seems to act as both an inducer and an inhibitor of the metabolism of repaglinide.

  European journal of clinical pharmacology 20040401

• Comparison of prediction methods for in vivo clearance of (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride, a dopamine D2 receptor antagonist, in humans.

  Drug metabolism and disposition: the biological fate of chemicals 20040401

• Hepatobiliary excretion of berberine.

  Drug metabolism and disposition: the biological fate of chemicals 20040401

• Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20040401

• Oral antiarrhythmic drugs in converting recent onset atrial fibrillation.

  Pharmacy world & science : PWS 20040401

• Influence of concomitant quinidine administration on dextromethorphan disposition in rats.

  Journal of veterinary pharmacology and therapeutics 20040401

• Transport of clonidine at cultured epithelial cells (JEG-3) of the human placenta.

  Pharmaceutical research 20040401

• Atrial fibrillation: rate control often better than rhythm control.

  Prescrire international 20040401

• Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone.

  Xenobiotica; the fate of foreign compounds in biological systems 20040401

• The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6.

  Drug metabolism and disposition: the biological fate of chemicals 20040401

• Single-channel properties and pH sensitivity of two-pore domain K+ channels of the TALK family.

  Biochemical and biophysical research communications 20040319

• Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.

  Biochemical and biophysical research communications 20040319

• Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay.

  The Journal of pharmacology and experimental therapeutics 20040301

• Crystal and molecular structures of new enantiopure quinuclidines.

  Chirality 20040301

• Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl.

  Journal of clinical pharmacology 20040301

• CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes.

  British journal of clinical pharmacology 20040301

• Tubifex tubifex Müll.--photosensitive organism.

  Central European journal of public health 20040301

• Diastereoisomer-selective inclusion complexation of Cinchona alkaloids with a modified beta-cyclodextrin: fluorescent behavior enhanced by chiral-tether binding. Short communication.

  Chemistry & biodiversity 20040301

• Pharmacokinetics and pharmacodynamic effects of amiodarone in plasma of ponies after single intravenous administration.

  Toxicology and applied pharmacology 20040215

• Alteration of room temperature phosphorescence lifetimes of quinine and quinidine by chiral additives.

  Chemical communications (Cambridge, England) 20040207

• Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain.

  Endocrinology 20040201

• The effect of parenteral nutrition fluids on the binding of therapeutic drugs to human serum in vitro.

  Therapeutic drug monitoring 20040201

• Mechanism-based inactivation of cytochrome P450 2D6 by 1-[(2-ethyl-4-methyl-1H-imidazol-5-yl)methyl]- 4-[4-(trifluoromethyl)-2-pyridinyl]piperazine: kinetic characterization and evidence for apoprotein adduction.

  Chemical research in toxicology 20040201

• In vivo metabolism of the new designer drug 1-(4-methoxyphenyl)piperazine (MeOPP) in rat and identification of the human cytochrome P450 enzymes responsible for the major metabolic step.

  Xenobiotica; the fate of foreign compounds in biological systems 20040201

• [Congenital myasthenic syndromes: phenotypic expression and pathophysiological characterisation].

  Revue neurologique 20040201

• [High throughput screening method of potassium channel regulators].

  Yao xue xue bao = Acta pharmaceutica Sinica 20040201

• Utility of microtiter plate assays for human cytochrome P450 inhibition studies in drug discovery: application of simple method for detecting quasi-irreversible and irreversible inhibitors.

  Drug metabolism and pharmacokinetics 20040201

• Catalytic asymmetric total syntheses of quinine and quinidine.

  Journal of the American Chemical Society 20040128

• Quinine/quinidine-induced thrombocytopenia: a great imitator.

  Archives of internal medicine 20040126

• Beta 2-adrenergic regulation of ciliary beat frequency in rat bronchiolar epithelium: potentiation by isosmotic cell shrinkage.

  The Journal of physiology 20040115

• Cytochrome P450 dependent metabolism of the new designer drug 1-(3-trifluoromethylphenyl)piperazine (TFMPP). In vivo studies in Wistar and Dark Agouti rats as well as in vitro studies in human liver microsomes.

  Biochemical pharmacology 20040115

• Variable modulation of opioid brain uptake by P-glycoprotein in mice.

  Biochemical pharmacology 20040115

• National trends in antiarrhythmic and antithrombotic medication use in atrial fibrillation.

  Archives of internal medicine 20040112

• Effects of solvent composition and ionic strength on the interaction of quinoline antimalarials with ferriprotoporphyrin IX.

  Journal of inorganic biochemistry 20040101

• Oxidative one-carbon cleavage of the octyl side chain of olanexidine, a novel antimicrobial agent, in dog liver microsomes.

  Xenobiotica; the fate of foreign compounds in biological systems 20040101

• Theoretical possibilities for the development of novel antiarrhythmic drugs.

  Current medicinal chemistry 20040101

• The influence of gender on arrhythmias.

  Cardiology in review 20040101

• Drug-drug interactions evaluated by a highly active reconstituted native human cytochrome P4503A4 and human NADPH-cytochrome P450 reductase system.

  Arzneimittel-Forschung 20040101

• Fatal attraction: synthetic musk fragrances compromise multixenobiotic defense systems in mussels.

  Marine environmental research 20040101

• QT prolongation in anaesthetized guinea-pigs: an experimental approach for preliminary screening of torsadogenicity of drugs and drug candidates.

  Journal of applied toxicology : JAT 20040101

• In vitro interaction of the HIV protease inhibitor ritonavir with herbal constituents: changes in P-gp and CYP3A4 activity.

  American journal of therapeutics 20040101

• Clinical review: clinical management of atrial fibrillation - rate control versus rhythm control.

  Critical care (London, England) 20040101

• Micro-electrode arrays in cardiac safety pharmacology: a novel tool to study QT interval prolongation.

  Drug safety 20040101

• Interactions between grapefruit juice and cardiovascular drugs.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20040101

• Characterization and function of TWIK-related acid sensing K+ channels in a rat nociceptive cell.

  Neuroscience 20040101

• The in vitro metabolism of desglymidodrine, an active metabolite of prodrug midodrine by human liver microsomes.

  European journal of drug metabolism and pharmacokinetics 20040101

• Drug-induced immune thrombocytopenia.

  Drug safety 20040101

• Effects of E4031 and quinidine on atrial and ventricular refractoriness in rabbits in vivo.

  Proceedings of the Western Pharmacology Society 20040101

• Antiarrhythmic profile and endothelial action of novel decahydroquinoline derivatives.

  Polish journal of pharmacology 20040101

• Identification of the cytochrome P450 enzymes involved in the metabolism of domperidone.

  Xenobiotica; the fate of foreign compounds in biological systems 20040101

• Renal elimination of a novel and potent alphavbeta3 integrin antagonist in animals.

  Xenobiotica; the fate of foreign compounds in biological systems 20040101

• Circumventing P-glycoprotein-mediated cellular efflux of quinidine by prodrug derivatization.

  Molecular pharmaceutics 20040101

• Role of pharmacotherapy in Brugada syndrome.

  Indian pacing and electrophysiology journal 20040101

• Congenital short QT syndrome.

  Indian pacing and electrophysiology journal 20040101

• Current concepts on ventricular fibrillation: a vicious circle of cardiomyocyte calcium overload in the initiation, maintenance, and termination of ventricular fibrillation.

  Indian pacing and electrophysiology journal 20040101

• Actual therapeutic management of allergic and hyperreactive nasal disorders.

  GMS current topics in otorhinolaryngology, head and neck surgery 20040101

• Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20031217

• Management of atrial fibrillation: review of the evidence for the role of pharmacologic therapy, electrical cardioversion, and echocardiography.

  Annals of internal medicine 20031216

• Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.

  Journal of the National Cancer Institute 20031203

• The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031201

• Inhibition of heme crystal growth by antimalarials and other compounds: implications for drug discovery.

  Biochemical pharmacology 20031201

• Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine.

  Clinical pharmacology and therapeutics 20031201

• Platelet function and immune response.

  Journal of pediatric hematology/oncology 20031201

• Atrioventricular nodal ablation and His-bundle pacing: an acute canine model for proarrhythmic risk assesment.

  Journal of cardiovascular electrophysiology 20031201

• Effect of P-glycoprotein on the ocular disposition of a model substrate, quinidine.

  Current eye research 20031201

• Study of inhibition of CYP2A6 by some drugs derived from quinoline.

  The Journal of pharmacy and pharmacology 20031201

• Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543.

  Xenobiotica; the fate of foreign compounds in biological systems 20031201

• 'Open access' generic method for continuous determination of major human CYP450 probe substrates/metabolites and its application in drug metabolism studies.

  Xenobiotica; the fate of foreign compounds in biological systems 20031201

• Nonselective cation channels activated by the stimulation of muscarinic receptors in mammalian gastric smooth muscle.

  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20031201

• Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.

  British journal of cancer 20031117

• Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers.

  Pharmacogenetics 20031101

• Effect of probenecid and quinidine on the transport of alovudine (3'-fluorothymidine) to the rat brain studied by microdialysis.

  Pharmacology & toxicology 20031101

• Ca(2+)-inactivated K+ current is modulated by endothelin-1 in B-16 murine melanoma cells.

  Pigment cell research 20031001

• The P-glycoprotein inhibitor quinidine decreases the threshold for bupivacaine-induced, but not lidocaine-induced, convulsions in rats.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20031001

• Respiratory and miotic effects of morphine in healthy volunteers when P-glycoprotein is blocked by quinidine.

  Clinical pharmacology and therapeutics 20031001

• Identification of cytochrome P450 enzymes involved in the metabolism of 4'-methoxy-alpha-pyrrolidinopropiophenone (MOPPP), a designer drug, in human liver microsomes.

  Xenobiotica; the fate of foreign compounds in biological systems 20031001

• Babesiosis. Two atypical cases from Minnesota and a review.

  American journal of clinical pathology 20031001

• A high-throughput method for enzyme kinetic studies.

  Journal of biomolecular screening 20031001

• High-performance liquid chromatographic method for the determination of quinine and 3-hydroxyquinine in blood samples dried on filter paper.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030925

• Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.

  International journal of pharmaceutics 20030916

• Intestinal elimination of albendazole sulfoxide: pharmacokinetic effects of inhibitors.

  International journal of pharmaceutics 20030916

• Uptake of histamine by mouse peritoneal macrophages and a macrophage cell line, RAW264.7.

  American journal of physiology. Cell physiology 20030901

• Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1.

  American journal of physiology. Cell physiology 20030901

• Metabolism and elimination of quinine in healthy volunteers.

  European journal of clinical pharmacology 20030901

• Medication-induced oesophageal disorders.

  Expert opinion on drug safety 20030901

• Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes.

  European journal of biochemistry 20030901

• Macroporous monolithic chiral stationary phases for capillary electrochromatography: New chiral monomer derived from cinchona alkaloid with enhanced enantioselectivity.

  Electrophoresis 20030901

• Synthesis of N-substituted-N-acylthioureas of 4-substituted piperazines endowed with local anaesthetic, antihyperlipidemic, antiproliferative activities and antiarrythmic, analgesic, antiaggregating actions.

  Farmaco (Societa chimica italiana : 1989) 20030901

• Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.

  Bioorganic & medicinal chemistry letters 20030818

• Lack of interaction of digoxin and P-glycoprotein inhibitors, quinidine and verapamil in human placenta in vitro.

  European journal of obstetrics, gynecology, and reproductive biology 20030815

• Ethanol excitation of dopaminergic ventral tegmental area neurons is blocked by quinidine.

  The Journal of pharmacology and experimental therapeutics 20030801

• Modulation of P-glycoprotein transport activity in the mouse blood-brain barrier by rifampin.

  The Journal of pharmacology and experimental therapeutics 20030801

• Up-regulation of vascular and renal mitogen-activated protein kinases in hypertensive rats is normalized by inhibitors of the Na+/Mg2+ exchanger.

  Clinical science (London, England : 1979) 20030801

• Conformational spaces of Cinchona alkaloids.

  Chirality 20030801

• Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes.

  Toxicology in vitro : an international journal published in association with BIBRA 20030801

• Evidence for the involvement of human liver microsomes CYP1A2 in the mono-hydroxylation of daidzein.

  Clinica chimica acta; international journal of clinical chemistry 20030801

• Identification of cytochrome p450 enzymes involved in the metabolism of 4'-methyl-alpha-pyrrolidinopropiophenone, a novel scheduled designer drug, in human liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20030801

• The metabolism of diclofenac--enzymology and toxicology perspectives.

  Current drug metabolism 20030801

• Effects of sex on the pharmacokinetic and pharmacodynamic properties of quinidine.

  British journal of clinical pharmacology 20030801

• pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions.

  Pharmaceutical research 20030801

• Quantitative evaluation of the function of small intestinal P-glycoprotein: comparative studies between in situ and in vitro.

  Pharmaceutical research 20030801

• Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers.

  Pharmaceutical research 20030801

• A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord.

  The Journal of biological chemistry 20030725

• Cinchona alkaloid derived ligands in catalytic asymmetric transfer hydrogenation.

  Organic & biomolecular chemistry 20030721

• Phosphorylation of the IKs channel complex inhibits drug block: novel mechanism underlying variable antiarrhythmic drug actions.

  Circulation 20030715

• Cause of atrioventricular block in patients after heart transplantation.

  Transplantation 20030715

• Role of human hepatic cytochrome P-450s in territrem A metabolism.

  Journal of toxicology and environmental health. Part A 20030711

• Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: study with cDNA-expressed systems of the rat.

  Drug metabolism and disposition: the biological fate of chemicals 20030701

• Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation.

  Drug metabolism and disposition: the biological fate of chemicals 20030701

• Physiologically based modelling of inhibition of metabolism and assessment of the relative potency of drug and metabolite: dextromethorphan vs. dextrorphan using quinidine inhibition.

  British journal of clinical pharmacology 20030701

• Interaction of quinidine, disopyramide and metoprolol with melanin in vitro in relation to drug-induced ocular toxicity.

  Die Pharmazie 20030701

• In vitro activation of 7-benzyloxyresorufin O-debenzylation and nifedipine oxidation in human liver microsomes.

  Xenobiotica; the fate of foreign compounds in biological systems 20030701

• Contribution of organic anion transporting polypeptide OATP-C to hepatic elimination of the opioid pentapeptide analogue [D-Ala2, D-Leu5]-enkephalin.

  The Journal of pharmacy and pharmacology 20030701

• Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide.

  Biochemical and biophysical research communications 20030627

• Identification of epitopes on cytochrome P450 3A4/5 recognized by monoclonal antibodies.

  Archives of biochemistry and biophysics 20030615

• Safety and feasibility of a clinical pathway for the outpatient initiation of antiarrhythmic medications in patients with atrial fibrillation or atrial flutter.

  The American journal of cardiology 20030615

• [Drug therapy of atrial fibrillation].

  Orvosi hetilap 20030615

• Drug interactions.

  The Medical letter on drugs and therapeutics 20030609

• Examination of the functional activity of P-glycoprotein in the rat placental barrier using rhodamine 123.

  The Journal of pharmacology and experimental therapeutics 20030601

• An amperometric biosensor with human CYP3A4 as a novel drug screening tool.

  Biochemical pharmacology 20030601

• Polymorphic hydroxylation of perhexiline in vitro.

  British journal of clinical pharmacology 20030601

• Extracellular acidosis modulates drug block of Kv4.3 currents by flecainide and quinidine.

  Journal of cardiovascular electrophysiology 20030601

• Swelling-activated chloride and potassium conductance in primary cultures of mouse proximal tubules. Implication of KCNE1 protein.

  The Journal of membrane biology 20030601

• Psychiatric side effects of medications prescribed in internal medicine.

  Dialogues in clinical neuroscience 20030601

• Treatment of slow-channel congenital myasthenic syndrome with fluoxetine.

  Neurology 20030527

• A novel O2-sensing mechanism in rat glossopharyngeal neurones mediated by a halothane-inhibitable background K+ conductance.

  The Journal of physiology 20030501

• Arachidonic acid activates an open rectifier potassium channel in cultured rat cortical astrocytes.

  Journal of neuroscience research 20030501

• Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole.

  Drug metabolism and disposition: the biological fate of chemicals 20030501

• Impact of nonspecific binding to microsomes and phospholipid on the inhibition of cytochrome P4502D6: implications for relating in vitro inhibition data to in vivo drug interactions.

  Drug metabolism and disposition: the biological fate of chemicals 20030501

• Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain.

  Molecular pharmacology 20030501

• Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man.

  European journal of clinical pharmacology 20030501

• Prediction of in vivo hepatic clearance from in vitro data using cryopreserved human hepatocytes.

  Xenobiotica; the fate of foreign compounds in biological systems 20030501

• Poor correlation between intestinal and hepatic metabolic rates of CYP3A4 substrates in rats.

  Pharmaceutical research 20030501

• Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.

  Journal of medicinal chemistry 20030424

• Quinidine impairs proliferation of neurofibromatosis type 2-deficient human malignant mesothelioma cells.

  Cancer 20030415

• Cytochrome P450 in vitro reaction phenotyping: a re-evaluation of approaches used for P450 isoform identification.

  Drug metabolism and disposition: the biological fate of chemicals 20030401

• Inhibition of P-glycoprotein by newer antidepressants.

  The Journal of pharmacology and experimental therapeutics 20030401

• Inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues.

  Chemical research in toxicology 20030401

• Effects of flecainide and quinidine on Kv4.2 currents: voltage dependence and role of S6 valines.

  British journal of pharmacology 20030401

• Procainamide and quinidine inhibition of the human hepatic degradation of meperidine in vitro.

  Journal of analytical toxicology 20030401

• Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.

  Pharmaceutical research 20030401

• Effect of nitric oxide on electrolyte transport across the porcine proximal colon.

  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20030401

• [Effects of Rbl on action potentials and force of contraction in guinea pig ventricular papillary muscles].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030401

• [Adverse drug reactions in three older patients, even without changes in medication].

  Nederlands tijdschrift voor geneeskunde 20030329

• Old and new antiarrhythmic drugs for converting and maintaining sinus rhythm in atrial fibrillation: comparative efficacy and results of trials.

  The American journal of cardiology 20030320

• Pharmacologic and nonpharmacologic options to maintain sinus rhythm: guideline-based and new approaches.

  The American journal of cardiology 20030320

• Fatty acid release and oxidation are factors in lipoxygenase inhibitor-induced apoptosis.

  Toxicology letters 20030303

• Oxidative metabolism of amprenavir in the human liver. Effect of the CYP3A maturation.

  Drug metabolism and disposition: the biological fate of chemicals 20030301

• Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: comparison with fluoxetine and quinidine.

  Drug metabolism and disposition: the biological fate of chemicals 20030301

• Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein.

  The Journal of pharmacology and experimental therapeutics 20030301

• Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1.

  Molecular pharmacology 20030301

• Metabolism and metabolic inhibition of cilnidipine in human liver microsomes.

  Acta pharmacologica Sinica 20030301

• Dissociation of E-4031 from the HERG channel caused by mutations of an amino acid results in greater block at high stimulation frequency.

  Cardiovascular research 20030301

• Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.

  Pharmacogenetics 20030301

• P-glycoprotein-mediated intestinal and biliary digoxin transport in humans.

  Clinical pharmacology and therapeutics 20030301

• Comparison of the effect of class IA antiarrhythmic drugs on transmembrane potassium currents in rabbit ventricular myocytes.

  Journal of cardiovascular pharmacology and therapeutics 20030301

• Digoxin remains useful in the management of chronic heart failure.

  The Medical clinics of North America 20030301

• Effect of isoproterenol on lipid peroxidation and antioxidant enzymes of myocardial tissue of mice and protection by quinidine.

  Molecular and cellular biochemistry 20030301

• Detection of proarrhythmia in the female rabbit heart: blinded validation.

  Journal of cardiovascular electrophysiology 20030301

• TCM treatment of extrasystole with huanglian shengmai yin--a report of 357 cases.

  Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20030301

• Chromatographic performance of large-pore versus small-pore columns in micellar liquid chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030225

• Enantiomer separation of N-protected amino acids by non-aqueous capillary electrophoresis and high-performance liquid chromatography with tert.-butyl carbamoylated quinine in either the background electrolyte or the stationary phase.

  Journal of chromatography. A 20030214

• Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis.

  Biochemistry 20030211

• The importance of the QT interval: a review of the literature.

  Acta psychiatrica Scandinavica 20030201

• Inhibitors of Na+/Mg2+ exchange activity attenuate the development of hypertension in angiotensin II-induced hypertensive rats.

  Journal of hypertension 20030201

• Amiodarone attenuates fluoride-induced hyperkalemia in vitro.

  Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 20030201

• Derivation of occupational exposure limits based on target blood concentrations in humans.

  Regulatory toxicology and pharmacology : RTP 20030201

• Selective binding of chiral molecules of cinchona alkaloid by beta- and gamma-cyclodextrins and organoselenium-bridged bis(beta-cyclodextrin)s.

  Bioorganic chemistry 20030201

• Influence of quinidine and flecainide on autonomic nervous activity in thoroughbred horses.

  The Veterinary record 20030125

• Kv1.4 channel block by quinidine: evidence for a drug-induced allosteric effect.

  The Journal of physiology 20030115

• Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.

  Journal of medicinal chemistry 20030102

• Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.

  Archives of biochemistry and biophysics 20030101

• High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20030101

• Differences in cytochrome P450 forms involved in the metabolism of N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine monohydrochloride (NE-100), a novel sigma ligand, in human liver and intestine.

  Drug metabolism and disposition: the biological fate of chemicals 20030101

• Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: importance of triangulation, reverse use dependence, and instability.

  Journal of cardiovascular pharmacology 20030101

• In vivo androgen treatment shortens the QT interval and increases the densities of inward and delayed rectifier potassium currents in orchiectomized male rabbits.

  Cardiovascular research 20030101

• Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp isolated from Cinchona pubescens.

  Chemical & pharmaceutical bulletin 20030101

• Role of CYP2D6 in the stereoselective disposition of venlafaxine in humans.

  Pharmacogenetics 20030101

• Highly stereoselective, uniformly sized molecularly imprinted polymers for cinchona alkaloids in hydro-organic mobile phases.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20030101

• Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate.

  Rapid communications in mass spectrometry : RCM 20030101

• Cerebral malaria: optimising management.

  CNS drugs 20030101

• Fluoroquinolones in the elderly: safety considerations.

  Drugs & aging 20030101

• Multivariate analysis of risk factors for QT prolongation following subarachnoid hemorrhage.

  Critical care (London, England) 20030101

• Catalyzation of cocaine N-demethylation by cytochromes P4502B, P4503A, and P4502D in fish liver.

  Journal of biochemical and molecular toxicology 20030101

• [Drug resistant tropical malaria in the Republic of Guinea (West Africa)].

  Meditsinskaia parazitologiia i parazitarnye bolezni 20030101

• Carnitine transport: pathophysiology and metabolism of known molecular defects.

  Journal of inherited metabolic disease 20030101

• [The antiarrhythmic activity of the trimecain ammonium derivative in myocardial ischemia].

  Eksperimental'naia i klinicheskaia farmakologiia 20030101

• Clinical review: Severe malaria.

  Critical care (London, England) 20030101

• V79 Chinese hamster cells genetically engineered for polymorphic cytochrome P450 2D6 and their predictive value for humans.

  ALTEX 20030101

• Drug transport studies using quantitative microdialysis.

  Methods in molecular medicine 20030101

• The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids.

  Malaria journal 20030101

• Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine.

  Malaria journal 20030101

• QT prolongation and fatal arrhythmias: a review of clinical implications and effects of drugs.

  American journal of therapeutics 20030101

• [Study of antiarrhythmic activity and duration of action of quaternidine].

  Eksperimental'naia i klinicheskaia farmakologiia 20030101

• Tramadol--the impact of its pharmacokinetic and pharmacodynamic properties on the clinical management of pain.

  Arzneimittel-Forschung 20030101

• Stereoselectivity in the pharmacodynamics and pharmacokinetics of the chiral antimalarial drugs.

  Clinical pharmacokinetics 20030101

• [Chronic heart failure and atrial fibrilation: aspects of management].

  Kardiologiia 20030101

• In-vitro response of Plasmodium falciparum to the main alkaloids of Cinchona in northwestern Thailand.

  Wiener klinische Wochenschrift 20030101

• Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).

  Journal of medicinal chemistry 20021219

• Delayed-onset amnesia caused by protein synthesis inhibition in odor-taste associative memory of the terrestrial slug Limax valentianus.

  Neuroscience letters 20021216

• Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro; 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway.

  Drug metabolism and disposition: the biological fate of chemicals 20021201

• Multiple cytochrome P450 enzymes responsible for the oxidative metabolism of the substituted (S)-3-phenylpiperidine, (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride, in human liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20021201

• Mechanism for the tissue distribution of grepafloxacin, a fluoroquinolone antibiotic, in rats.

  Drug metabolism and disposition: the biological fate of chemicals 20021201

• Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach.

  Drug metabolism and disposition: the biological fate of chemicals 20021201

• Assembly with the Kvbeta1.3 subunit modulates drug block of hKv1.5 channels.

  Molecular pharmacology 20021201

• Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives.

  Acta pharmacologica Sinica 20021201

• Quinine pharmacokinetics in chronic haemodialysis patients.

  British journal of clinical pharmacology 20021201

• Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?

  British journal of clinical pharmacology 20021201

• MDR1-mediated interaction of digoxin with antiarrhythmic or antianginal drugs.

  Biological & pharmaceutical bulletin 20021201

• Differences in pharmacokinetics and hepatobiliary transport of a novel anti-inflammatory agent between normal and adjuvant arthritis rats.

  Xenobiotica; the fate of foreign compounds in biological systems 20021201

• KV2.1 K+ channels underlie major voltage-gated K+ outward current in H9c2 myoblasts.

  The Japanese journal of physiology 20021201

• Development of neuroleptic agents: pharmacogenetics and current safety issues of regulatory concern.

  Dialogues in clinical neuroscience 20021201

• HL60 cells halted in G1 or S phase differentiate normally.

  Experimental cell research 20021115

• Myc protein is differentially sensitive to quinidine in tumor versus immortalized breast epithelial cell lines.

  International journal of cancer 20021101

• Evaluation of the permeation characteristics of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs across the blood-brain barrier using an in situ perfused rat brain model.

  The Journal of pharmacology and experimental therapeutics 20021101

• Intracellular calcium was involved in muscarinic currents increased by hypoosmotic membrane stretch in gastric myocytes of guinea pig.

  Acta pharmacologica Sinica 20021101

• What is the minimal pacing rate that prevents torsades de pointes? Insights from patients with permanent pacemakers.

  Pacing and clinical electrophysiology : PACE 20021101

• Electrocardiographic toxicity in the guinea pig.

  Current protocols in pharmacology 20021101

• Diclofenac-induced inactivation of CYP3A4 and its stimulation by quinidine.

  Drug metabolism and disposition: the biological fate of chemicals 20021001

• Stereoselective metabolism of bufuralol racemate and enantiomers in human liver microsomes.

  The Journal of pharmacology and experimental therapeutics 20021001

• [Recent onset atrial fibrillation at a unit of internal medicine].

  Recenti progressi in medicina 20021001

• Oxidation of methoxyphenethylamines by cytochrome P450 2D6. Analysis of rate-limiting steps.

  The Journal of biological chemistry 20020913

• Stem cell-derived cardiomyocytes demonstrate arrhythmic potential.

  Circulation 20020903

• Mode-dependent inhibition by quinidine of Na+-Ca2+ exchanger current from guinea-pig isolated ventricular myocytes.

  Clinical and experimental pharmacology & physiology 20020901

• The interactions of a selective protein kinase C beta inhibitor with the human cytochromes P450.

  Drug metabolism and disposition: the biological fate of chemicals 20020901

• Maintaining stability of sinus rhythm in atrial fibrillation: antiarrhythmic drugs versus ablation.

  Current cardiology reports 20020901

• Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein.

  Journal of experimental botany 20020901

• Characterization of quinidine 3-hydroxylation as a probe for the CYP 3A enzyme using a novel capillary electrophoresis technique.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020901

• Quinidine does not affect the renal clearance of moxonidine.

  British journal of clinical pharmacology 20020901

• [Elective cardioversion of atrial fibrillation. Are quinidine and electrical shock really equivalent?].

  Revista espanola de cardiologia 20020901

• Control of mammary tumor cell growth in vitro by novel cell differentiation and apoptosis agents.

  Breast cancer research and treatment 20020901

• Atrial fibrillation: onset and perpetuation.

  Veterinary journal (London, England : 1997) 20020901

• Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity.

  Life sciences 20020816

• Analysis of the Cinchona alkaloids by high-performance liquid chromatography and other separation techniques.

  Journal of chromatography. A 20020816

• Solution structures of antimalarial drug-heme complexes.

  Biochemistry 20020813

• Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method.

  Drug metabolism and disposition: the biological fate of chemicals 20020801

• Effects of quinine and quinidine on the transient outward and on the L-type Ca(2+) current in rat ventricular cardiomyocytes.

  Pharmacology 20020801

• Effects of cigarette smoking on quinine pharmacokinetics in malaria.

  European journal of clinical pharmacology 20020801

• The functional properties of the human ether-à-go-go-like (HELK2) K+ channel.

  The European journal of neuroscience 20020801

• The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver.

  British journal of clinical pharmacology 20020801

• How to enhance acute outcome of electrical cardioversion by drug therapy: importance of immediate reinitiation of atrial fibrillation.

  Journal of cardiovascular electrophysiology 20020801

• Advantages of in vitro cytotoxicity testing by using primary rat hepatocytes in comparison with established cell lines.

  The Journal of toxicological sciences 20020801

• Characterization of four types of background potassium channels in rat cerebellar granule neurons.

  The Journal of physiology 20020715

• Highly selective hydroformylation of the cinchona alkaloids.

  The Journal of organic chemistry 20020712

• Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine.

  British journal of pharmacology 20020701

• cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.

  Journal of the American Society of Nephrology : JASN 20020701

• The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19.

  Pharmaceutical research 20020701

• The effects of antimalarial drugs on ventricular repolarization.

  The American journal of tropical medicine and hygiene 20020701

• [Antiarrhythmic drugs in atrial fibrillation].

  La Revue du praticien 20020615

• Cloning of two transcripts, HKT4.1a and HKT4.1b, from the human two-pore K+ channel gene KCNK4. Chromosomal localization, tissue distribution and functional expression.

  Brain research. Molecular brain research 20020615

• Treatment of codeine dependence with inhibitors of cytochrome P450 2D6.

  Journal of clinical psychopharmacology 20020601

• Change from the CYP2D6 extensive metabolizer to the poor metabolizer phenotype during treatment With bupropion.

  Therapeutic drug monitoring 20020601

• 4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine.

  The Journal of pharmacology and experimental therapeutics 20020601

• Cardiac electrophysiologic and antiarrhythmic actions of a pavine alkaloid derivative, O-methyl-neocaryachine, in rat heart.

  British journal of pharmacology 20020601

• Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana Moens ex Trimen.

  Bioorganic & medicinal chemistry letters 20020520

• Rifampin and rifabutin drug interactions: an update.

  Archives of internal medicine 20020513

• Subconductance activity induced by quinidine and quinidinium in purified cardiac sarcoplasmic reticulum calcium release channels.

  The Journal of pharmacology and experimental therapeutics 20020501

• The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine.

  British journal of clinical pharmacology 20020501

• Oral quinidine therapy for chronic atrial fibrillation.

  Journal of cardiology 20020501

• [Slow channel syndrome due to an autosomal translocation at 2q31-9p27].

  Revue neurologique 20020501

• Asymmetric chelated Claisen rearrangements in the presence of chiral ligands--scope and limitations.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20020415

• AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae.

  Biochemical and biophysical research communications 20020405

• The anthelminthic agent albendazole does not interact with p-glycoprotein.

  Drug metabolism and disposition: the biological fate of chemicals 20020401

• A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?

  The Journal of physiology 20020401

• Stereoselective transport of hydrophilic quaternary drugs by human MDR1 and rat Mdr1b P-glycoproteins.

  British journal of pharmacology 20020401

• Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice.

  British journal of pharmacology 20020401

• Whole-cell recording from honeybee olfactory receptor neurons: ionic currents, membrane excitability and odourant response in developing workerbee and drone.

  The European journal of neuroscience 20020401

• Augmentation of the activity of an immunotoxin, anti-Tac(Fv)-PE40KDEL, in T cell lines infected with human T cell leukemia virus type-I.

  Leukemia & lymphoma 20020401

• Use of biphasic electrical cardioversion for treatment of idiopathic atrial fibrillation in two horses.

  Journal of the American Veterinary Medical Association 20020401

• Functional distinction of human EAG1 and EAG2 potassium channels.

  FEBS letters 20020313

• Influence of the ORM1 phenotypes on serum unbound concentration and protein binding of quinidine.

  Clinica chimica acta; international journal of clinical chemistry 20020301

• Limited antifibrillatory effectiveness of clinically relevant concentrations of class I antiarrhythmics in isolated perfused rat hearts.

  Journal of cardiovascular pharmacology 20020301

• Colour reactions of PH. EUR. for identification of drugs using 1,3-dibromo-5,5-dimethylhydantoin (DBH) instead of elemental bromine. Analytical methods of pharmacopoeias with DBH in respect to environmental and economical concern, Part 10.

  Die Pharmazie 20020301

• Effects of estrogen on cardiac electrophysiology in female mice.

  Journal of cardiovascular electrophysiology 20020301

• Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.

  Pharmacology & toxicology 20020301

• [Stereoselectivity in O-demethylation of trans tramadol in rat liver microsomes in vitro].

  Yao xue xue bao = Acta pharmaceutica Sinica 20020301

• Enantiomeric separation of N-protected amino acids by non-aqueous capillary electrophoresis with dimeric forms of quinine and quinidine derivatives serving as chiral selectors.

  Journal of chromatography. A 20020301

• Basolateral potassium channels of rabbit colon epithelium: role in sodium absorption and chloride secretion.

  Biochimica et biophysica acta 20020218

• The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations.

  The Journal of biological chemistry 20020215

• A co-culture-based model of human blood-brain barrier: application to active transport of indinavir and in vivo-in vitro correlation.

  Brain research 20020215

• Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance.

  International journal of cancer 20020210

• A Shaker homologue encodes an A-type current in Xenopus laevis.

  Brain research 20020208

• [Why is QT interval interesting?].

  Ugeskrift for laeger 20020204

• Proarrhythmic effects of intravenous quinidine, amiodarone, D-sotalol, and almokalant in the anesthetized rabbit model of torsade de pointes.

  Journal of cardiovascular pharmacology 20020201

• Determination of (3S)-3-hydroxy quinidine for metabolism screening experiments using direct injection capillary electrophoresis and laser-induced fluorescence detection.

  Biomedical chromatography : BMC 20020201

• Ionic basis of the resting membrane potential and action potential in the pharyngeal muscle of Caenorhabditis elegans.

  Journal of neurophysiology 20020201

• [The efficacy of scheduled cardioversion in atrial fibrillation. Comparison of two schemes of treatment: electrical versus pharmacological cardioversion].

  Revista espanola de cardiologia 20020201

• Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.

  Pharmaceutical research 20020201

• Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum.

  Molecular pharmacology 20020101

• Drug interactions with patient-controlled analgesia.

  Clinical pharmacokinetics 20020101

• Evidence for the possible involvement of Ca2+ entry blockade in the relaxation by class I antiarrhythmic drugs in the isolated pig coronary smooth muscle.

  Naunyn-Schmiedeberg's archives of pharmacology 20020101

• Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).

  European journal of human genetics : EJHG 20020101

• Risk of mortality in a cohort of patients newly diagnosed with chronic atrial fibrillation.

  BMC cardiovascular disorders 20020101

• Adverse effects of the antimalaria drug, mefloquine: due to primary liver damage with secondary thyroid involvement?

  BMC public health 20020101

• The molecular basis of cardiac arrhythmias.

  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20020101

• Proliferation and morphological transformation of RMK cells exposed to hydroquinine containing ionomers.

  Biomedical sciences instrumentation 20020101

• Serum quinidine concentrations and effect on QT dispersion and interval.

  The Annals of pharmacotherapy 20020101

• Does lindane (gamma-hexachlorocyclohexane) increase the rapid delayed rectifier outward K+ current (IKr) in frog atrial myocytes?

  BMC pharmacology 20020101

• In vivo effect of 5- and 8-methoxypsoralens and cimetidine on R,S-warfarin metabolism in rat.

  Journal of applied toxicology : JAT 20020101

• Kinetic analysis for multiple substrate interaction at the active site of cytochrome P450.

  Methods in enzymology 20020101

• Choline transport in Leishmania major promastigotes and its inhibition by choline and phosphocholine analogs.

  Molecular and biochemical parasitology 20020101

• New crystalline complex of quinine and quinidine.

  Enantiomer 20020101

• Use of beta-blockers in atrial fibrillation.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20020101

• Comparative analysis of in vitro and in vivo pharmacokinetic parameters related to individual variability of GTS-21 in canine.

  Drug metabolism and pharmacokinetics 20020101

• mRNA expression and amino acid transport characteristics of cultured human brain microvascular endothelial cells (hBME).

  Drug metabolism and pharmacokinetics 20020101

• Involvement of specific transport system of renal basolateral membranes in distribution of nicotine in rats.

  Drug metabolism and pharmacokinetics 20020101

• Antimalarial drugs inhibit the acetylcholine-receptor-operated potassium current in atrial myocytes.

  Heart, lung & circulation 20020101

• The long QT syndrome.

  Indian pacing and electrophysiology journal 20020101

• Non-pharmacological treatment of atrial fibrillation.

  Indian pacing and electrophysiology journal 20020101

• The antidotal effect of alpha(1)-acid glycoprotein on amitriptyline toxicity in cardiac myocytes.

  Toxicology 20011214

• [Atrial fibrillation successfully converted. A new standard in the prevention of recurrence?].

  MMW Fortschritte der Medizin 20011213

• [Unexpected high plasma level of drugs. Blocked transporter can be the cause].

  MMW Fortschritte der Medizin 20011213

• Rutaecarpine-induced block of delayed rectifier K+ current in NG108-15 neuronal cells.

  Neuropharmacology 20011201

• Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein.

  Pharmaceutical research 20011201

• Safety and effectiveness of oral quinidine in cardioversion of persistent atrial fibrillation.

  Journal of cardiology 20011201

• Lead ions but not other metallic ions increase resistance to hypotonic lysis in prenatal hemopoiesis red blood cells.

  Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20011201

• A case series of drug-induced long QT syndrome and Torsade de Pointes.

  Singapore medical journal 20011201

• Transport characteristics of grepafloxacin and levofloxacin in the human intestinal cell line Caco-2.

  European journal of pharmacology 20011123

• Drug block of I(kr): model systems and relevance to human arrhythmias.

  Journal of cardiovascular pharmacology 20011101

• Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes.

  Journal of the American College of Cardiology 20011101

• Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011.

  Biological & pharmaceutical bulletin 20011101

• Differential inhibition of human CYP1A1 and CYP1A2 by quinidine and quinine.

  Xenobiotica; the fate of foreign compounds in biological systems 20011101

• Amiodarone -- waxed and waned and waxed again.

  Expert opinion on pharmacotherapy 20011101

• An amino acid residue whose change by mutation affects drug binding to the HERG channel.

  FEBS letters 20011012

• Different enantioselective 9-hydroxylation of risperidone by the two human CYP2D6 and CYP3A4 enzymes.

  Drug metabolism and disposition: the biological fate of chemicals 20011001

• In vitro metabolism of tegaserod in human liver and intestine: assessment of drug interactions.

  Drug metabolism and disposition: the biological fate of chemicals 20011001

• Functional expression of P-glycoprotein in rat brain microglia.

  The Journal of pharmacology and experimental therapeutics 20011001

• Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK and HERG.

  The Journal of pharmacology and experimental therapeutics 20011001

• Functional characteristics and steroid hormone-mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells.

  The Journal of pharmacology and experimental therapeutics 20011001

• In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense.

  Planta medica 20011001

• GAT2/BGT-1 as a system responsible for the transport of gamma-aminobutyric acid at the mouse blood-brain barrier.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20011001

• Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test.

  Clinical pharmacology and therapeutics 20011001

• Glycoprotein V-specific platelet-associated antibodies in thrombocytopenic patients.

  Clinical and laboratory haematology 20011001

• Influence of P-glycoprotein on the transplacental passage of cyclosporine.

  Journal of pharmaceutical sciences 20011001

• Purinoreceptors are involved in the control of acute morphine withdrawal.

  Life sciences 20010921

• [Immuno-allergic cytopenias].

  La Revue du praticien 20010915

• Three thiadiazinone derivatives, EMD 60417, EMD 66430, and EMD 66398, with class III antiarrhythmic activity but different electrophysiologic profiles.

  Journal of cardiovascular pharmacology 20010901

• Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1.

  American journal of physiology. Renal physiology 20010901

• Metabolism of vanoxerine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, by human cytochrome P450 enzymes.

  Drug metabolism and disposition: the biological fate of chemicals 20010901

• Multidrug resistance-associated protein-1 functional activity in Calu-3 cells.

  The Journal of pharmacology and experimental therapeutics 20010901

• Inactivation of rat cytochrome P450 2D enzyme by a further metabolite of 4-hydroxypropranolol, the major and active metabolite of propranolol.

  Biological & pharmaceutical bulletin 20010901

• Quinidine induced electrocardiographic normalization in two patients with Brugada syndrome.

  Pacing and clinical electrophysiology : PACE 20010901

• Development of stereoselective nonaqueous capillary electrophoresis system for the resolution of cationic and amphoteric analytes.

  Electrophoresis 20010901

• Alkaline phosphatase from rat liver and kidney is differentially modulated.

  Clinical biochemistry 20010901

• Interactions of 1-methyl-4-phenylpyridinium and other compounds with P-glycoprotein: relevance to toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

  Brain research 20010810

• Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram.

  Drug metabolism and disposition: the biological fate of chemicals 20010801

• Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20010801

• Independent organic cation transport activity of Na(+)-L-carnitine cotransport system in LLC-PK(1) cells.

  American journal of physiology. Renal physiology 20010801

• Study of tea polyphenol as a reversal agent for carcinoma cell lines' multidrug resistance (study of TP as a MDR reversal agent).

  Nuclear medicine and biology 20010801

• [Pharmacokinetics and drug interactions of antidepressive agents].

  Nihon rinsho. Japanese journal of clinical medicine 20010801

• Binding constant determination of drugs toward subdomain IIIA of human serum albumin by near-infrared dye-displacement capillary electrophoresis.

  Electrophoresis 20010801

• The potential for CYP2D6 inhibition screening using a novel scintillation proximity assay-based approach.

  Journal of biomolecular screening 20010801

• Characterization and localization of cytochrome P450 mediated metabolism of MPTP to nor-MPTP in mouse brain: relevance to Parkinson's disease.

  Neurotoxicity research 20010801

• ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.

  Journal of medicinal chemistry 20010719

• Novel target genes of the yeast regulator Pdr1p: a contribution of the TPO1 gene in resistance to quinidine and other drugs.

  Gene 20010711

• A direct injection capillary electrophoretic technique for miniaturized high-throughput metabolic screening of the CYP 3A4 enzyme using quinidine as a probe.

  Journal of pharmaceutical and biomedical analysis 20010701

• Cytochrome P450-catalyzed metabolism of ezlopitant alkene (CJ-12,458), a pharmacologically active metabolite of ezlopitant: enzyme kinetics and mechanism of an alkene hydration reaction.

  Drug metabolism and disposition: the biological fate of chemicals 20010701

• Comparison of 'type I' and 'type II' organic cation transport by organic cation transporters and organic anion-transporting polypeptides.

  The Journal of pharmacology and experimental therapeutics 20010701

• Effect of mdr1a P-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds.

  Pharmaceutical research 20010701

• Mechanism-based inactivation of CYP2D6 by 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine.

  Drug metabolism and disposition: the biological fate of chemicals 20010601

• In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4'- and 10-hydroxywarfarin.

  Drug metabolism and disposition: the biological fate of chemicals 20010601

• Effect of capillary efflux transport inhibition on the determination of probe recovery during in vivo microdialysis in the brain.

  The Journal of pharmacology and experimental therapeutics 20010601

• Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology.

  Toxicology in vitro : an international journal published in association with BIBRA 20010601

• Synchronized neural activity in the Drosophila memory centers and its modulation by amnesiac.

  Neuron 20010601

• Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions.

  Current drug metabolism 20010601

• Coumarin substrates for cytochrome P450 2D6 fluorescence assays.

  Analytical biochemistry 20010515

• Evaluation of the contribution to enantioselectivity of quinine and quinidine scaffolds in chemically and physically mixed chiral selectors.

  Chirality 20010505

• Metabolism of sulfinpyrazone sulfide and sulfinpyrazone by human liver microsomes and cDNA-expressed cytochrome P450s.

  Drug metabolism and disposition: the biological fate of chemicals 20010501

• Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.

  Molecular pharmacology 20010501

• Mechanical effects of liriodenine on the left ventricular-arterial coupling in Wistar rats: pressure-stroke volume analysis.

  British journal of pharmacology 20010501

• Interactions between antiarrhythmic drugs and cardiac memory.

  Cardiovascular research 20010501

• Quinidine as an antiarrhythmic.

  Chest 20010501

• Effect of P-glycoprotein on flavopiridol sensitivity.

  British journal of cancer 20010501

• Bufuralol metabolism by guinea pig adrenal and hepatic microsomes.

  Pharmacology 20010501

• Oral quinine pharmacokinetics and dietary salt intake.

  European journal of clinical pharmacology 20010501

• Metabolism of amiodarone (Part III): identification of rabbit cytochrome P450 isoforms involved in the hydroxylation of mono-N-desethylamiodarone.

  Xenobiotica; the fate of foreign compounds in biological systems 20010501

• Angiotensin II type I receptor modulates intracellular free Mg2+ in renally derived cells via Na+-dependent Ca2+-independent mechanisms.

  The Journal of biological chemistry 20010427

• Quinidine and malaria.

  Archives of internal medicine 20010423

• Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6.

  The Biochemical journal 20010415

• Simultaneous determination of quinine and four metabolites in plasma and urine by high-performance liquid chromatography.

  Journal of chromatography. B, Biomedical sciences and applications 20010415

• High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. II. Validation of a direct injection/on-line guard cartridge extraction-tandem mass spectrometry method for CYP2D6 inhibition assessment.

  Journal of chromatography. B, Biomedical sciences and applications 20010405

• Simultaneous measurement of plasma ropivacaine and bupivacaine concentrations by HPLC with UV detection.

  Therapeutic drug monitoring 20010401

• Factors influencing the prediction of steady state concentrations of digoxin.

  Biological & pharmaceutical bulletin 20010401

• Cardiovascular effects of verapamil and quinidine at normal and elevated ambient pressure.

  Aviation, space, and environmental medicine 20010401

• HPTLC method for the estimation of alkaloids of Cinchona officinalis stem bark and its marketed formulations.

  Planta medica 20010401

• CIBIS, MERIT-HF, and COPERNICUS trial outcomes: do they complete the chapter on beta-adrenergic blockers as antiarrhythmic and antifibrillatory drugs?

  Journal of cardiovascular pharmacology and therapeutics 20010401

• Importance of QT interval determination and renal function assessment during antiarrhythmic drug therapy.

  Journal of cardiovascular pharmacology and therapeutics 20010401

• Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels.

  Biochemical and biophysical research communications 20010323

• Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole.

  Toxicological sciences : an official journal of the Society of Toxicology 20010301

• Ascorbic acid-induced modulation of venous tone in humans.

  Hypertension (Dallas, Tex. : 1979) 20010301

• Capillary electrophoretic separation, immunochemical recognition and analysis of the diastereomers quinine and quinidine and two quinidine metabolites in body fluids.

  Journal of pharmaceutical and biomedical analysis 20010301

• Moxifloxacin: clinical efficacy and safety.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20010301

• Characterization of (+/-)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6.

  Pharmacogenetics 20010301

• Effect of hydroxyzine on the transport of etoposide in rat small intestine.

  Anti-cancer drugs 20010301

• Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil.

  British journal of clinical pharmacology 20010301

• Persistence of Plasmodium falciparum in the placenta after apparently effective quinidine/clindamycin therapy.

  Journal of perinatology : official journal of the California Perinatal Association 20010301

• Calcium-activated potassium current in single Novikoff cell.

  Methods and findings in experimental and clinical pharmacology 20010301

• From the Centers for Disease Control and Prevention. Availability and use of parenteral quinidine gluconate for severe or complicated malaria.

  JAMA 20010214

• CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.

  Drug metabolism and disposition: the biological fate of chemicals 20010201

• Modulation of P450 CYP3A4-dependent metabolism by P-glycoprotein: implications for P450 phenotyping.

  The Journal of pharmacology and experimental therapeutics 20010201

• Characterization of a novel cationic drug transporter in human retinal pigment epithelial cells.

  The Journal of pharmacology and experimental therapeutics 20010201

• Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2.

  Molecular pharmacology 20010201

• Effect of coadministered drugs and ethanol on the binding of therapeutic drugs to human serum in vitro.

  Therapeutic drug monitoring 20010201

• Single oral loading dose of propafenone for pharmacological cardioversion of recent-onset atrial fibrillation.

  Journal of the American College of Cardiology 20010201

• A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells.

  Pharmaceutical research 20010201

• Improved intestinal absorption of sulpiride in rats with synchronized oral delivery systems.

  Journal of controlled release : official journal of the Controlled Release Society 20010129

• Salt and cosolvent effects on ionic drug loading into microspheres using an O/W method.

  Journal of controlled release : official journal of the Controlled Release Society 20010129

• Evaluation of a vincristine resistant Caco-2 cell line for use in a calcein AM extrusion screening assay for P-glycoprotein interaction.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010101

• A novel zidovudine uptake system in microglia.

  The Journal of pharmacology and experimental therapeutics 20010101

• A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry.

  Drug metabolism and disposition: the biological fate of chemicals 20010101

• Transport of [3H]MPP+ in an immortalized rat brain microvessel endothelial cell line (RBE 4).

  Naunyn-Schmiedeberg's archives of pharmacology 20010101

• How do I prolong QT? Let me count the ways.

  Journal of cardiovascular electrophysiology 20010101

• Sympathetic activation enhances QT prolongation by quinidine.

  Journal of cardiovascular electrophysiology 20010101

• Species plays an important role in drug-induced prolongation of action potential duration and early afterdepolarizations in isolated Purkinje fibers.

  Journal of cardiovascular electrophysiology 20010101

• A high-performance liquid chromatographic assay for the determination of desbutylhalofantrine enantiomers in rat plasma.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20010101

• A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function.

  Pharmaceutical research 20010101

• Evaluation of drug-induced QT interval prolongation: implications for drug approval and labelling.

  Drug safety 20010101

• Pharmacokinetic interactions of antimalarial agents.

  Clinical pharmacokinetics 20010101

• Alteration of drug kinetics in rats following exposure to trichloroethylene.

  Pharmacology 20010101

• Effect of hydrophilic substances on liberation of quinidine from starch - alginate sphere.

  Acta poloniae pharmaceutica 20010101

• Drug interaction studies with esomeprazole, the (S)-isomer of omeprazole.

  Clinical pharmacokinetics 20010101

• Cytochrome P450 enzymes involved in the metabolic pathway of the histamine 2 (H2)-receptor antagonist roxatidine acetate by human liver microsomes.

  Arzneimittel-Forschung 20010101

• In vitro evaluation of quinidine sensitivity in Brazilian Plasmodium falciparum isolates: comparative analysis to quinine and chloroquine.

  Revista do Instituto de Medicina Tropical de Sao Paulo 20010101

• Pharmacologic conversion of atrial fibrillation: a systematic review of available evidence.

  Progress in cardiovascular diseases 20010101

• Role of transport proteins in drug absorption, distribution and excretion.

  Xenobiotica; the fate of foreign compounds in biological systems 20010101

• Is it Crohn's disease? A severe systemic granulomatous reaction to sulfasalazine in patient with rheumatoid arthritis.

  BMC gastroenterology 20010101

• [Congenital myasthenic syndrome (CMS) caused by postsynaptic defects].

  Ryoikibetsu shokogun shirizu 20010101

• [A severe form of falciparum malaria associated with staphylococcal endocarditis].

  Vojnosanitetski pregled 20010101

• Renovascular actions of adenosine in the isolated perfused rat kidney: possible underlying mechanisms.

  Journal of basic and clinical physiology and pharmacology 20010101

• [Effect of quinine and quinidine on the status of hematopoietic and lymphoid organs].

  Eksperimental'naia i klinicheskaia farmakologiia 20010101

• Is arrhythmogenic right ventricular cardiomyopathy a paediatric problem too?

  Images in paediatric cardiology 20010101

• TWIK-2, an inactivating 2P domain K+ channel.

  The Journal of biological chemistry 20000915

• Images in cardiovascular medicine. Labile repolarization from 'cell to bedside'.

  Circulation 20000815

• Amiodarone-induced AV block and ventricular standstill. A forme fruste of an idiopathic long QT syndrome.

  International journal of cardiology 20000801

• Metabolism of 3-methylindole by porcine liver microsomes: responsible cytochrome P450 enzymes.

  Toxicological sciences : an official journal of the Society of Toxicology 20000601

• TASK-3, a new member of the tandem pore K(+) channel family.

  The Journal of biological chemistry 20000331

• Fluorometric screening for metabolism-based drug--drug interactions.

  Journal of pharmacological and toxicological methods 20000101

• Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).

  The Journal of pharmacology and experimental therapeutics 19980701

• [Quinidine-induced syncope simulating transient cerebral ischemic attack].

  Orvosi hetilap 19980607

• Effects of quinidine and verapamil on human cardiovascular alpha1-adrenoceptors.

  Circulation 19980407

• Life-threatening vasculitis related to quinidine occurring in a healthy volunteer during a clinical trial.

  European journal of clinical pharmacology 19980101

• Amiodarone induced torsades de pointes with excessive QT dispersion following quinidine induced polymorphic ventricular tachycardia.

  Pacing and clinical electrophysiology : PACE 19970901

• Torsade de pointes with amiodarone in a patient with previous torsade during beta-receptor blockade.

  The Canadian journal of cardiology 19970401

• Management of quinidine syncope in twenty cases.

  Chinese medical journal 19970401

• Prolonged quinidine half-life with associated toxicity in a patient with hepatic failure.

  Pharmacotherapy 19970101

• QT prolongation and development of torsades de pointes with the concomitant administration of oral erythromycin base and quinidine.

  Pharmacotherapy 19970101

• [Hypersensitive urticarial vasculitis after natisedine intake].

  Annales de dermatologie et de venereologie 19970101

• Atrial flutter with 1:1 conduction after administration of the antimalarial drug mefloquine.

  Clinical cardiology 19961201

• Tobacco budworm P-glycoprotein: biochemical characterization and its involvement in pesticide resistance.

  Biochimica et biophysica acta 19961024

• Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels.

  Proceedings of the National Academy of Sciences of the United States of America 19960820

• Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes.

  Xenobiotica; the fate of foreign compounds in biological systems 19960701

• P-glycoprotein involvement in cuticular penetration of [14C]thiodicarb in resistant tobacco budworms.

  Toxicology letters 19960601

• [Torsade de pointes during quinidine and amiodarone therapy].

  Medizinische Klinik (Munich, Germany : 1983) 19960315

• Comparisons of oral propafenone and quinidine as an initial treatment option in patients with symptomatic paroxysmal atrial fibrillation: a double-blind, randomized trial.

  Journal of internal medicine 19960301

• Prospective comparison of flecainide versus quinidine for the treatment of paroxysmal atrial fibrillation/flutter. The Flecainide Multicenter Atrial Fibrillation Study Group.

  The American journal of cardiology 19960125

• Comparison of sotalol with digoxin-quinidine for conversion of acute atrial fibrillation to sinus rhythm (the Sotalol-Digoxin-Quinidine Trial).

  The American journal of cardiology 19950901

• Antiarrhythmic and bradycardic drugs inhibit currents of cloned K+ channels, KV1.2 and KV1.4.

  European journal of pharmacology 19950804

• Proarrhythmic effects of a quinidine analog in dogs with chronic A-V block.

  Fundamental & clinical pharmacology 19950101

• Monitoring of intravenous quinidine infusion in the treatment of Plasmodium falciparum malaria.

  The Annals of pharmacotherapy 19950101

• [Use of cyclosporin and verapamil in association with chemotherapy in the treatment of pediatric patients with advanced-stage neoplasms. A pilot study].

  Minerva pediatrica 19941001

• Differences in corrected QT intervals at minimal and maximal heart rate may identify patients at risk for torsades de pointes during treatment with antiarrhythmic drugs.

  Journal of cardiovascular electrophysiology 19940501

• Usefulness of oral quinidine-mexiletine combination therapy for sustained ventricular tachyarrhythmias as assessed by programmed electrical stimulation when quinidine monotherapy has failed.

  American heart journal 19940401

• Torsade de pointes complicating drug treatment of low-malignant forms of arrhythmia: four cases reports.

  Clinical cardiology 19940401

• Managing chronic atrial fibrillation: a Markov decision analysis comparing warfarin, quinidine, and low-dose amiodarone.

  Annals of internal medicine 19940315

• D-penicillamine- and quinidine-induced antinuclear antibodies in A.SW (H-2s) mice: similarities with autoantibodies in spontaneous and heavy metal-induced autoimmunity.

  European journal of immunology 19940301

• Susceptibility of ageing kidney to quinidine.

  Pharmacological research 19940101

• Delirium at therapeutic serum concentrations of digoxin and quinidine.

  Psychosomatics 19940101

• Class I antiarrhythmic drugs: allosteric inhibitors of [3H] batrachotoxinin binding to rat cardiac sodium channels.

  The Journal of pharmacology and experimental therapeutics 19940101

• Mechanisms of ventricular arrhythmia during amitriptyline toxicity.

  Journal of cardiovascular pharmacology 19931201

• Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs.

  JAMA 19931201

• Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies.

  Journal of medicinal chemistry 19930430

• The effectiveness and safety of the simultaneous administration of quinidine and amiodarone in the conversion of chronic atrial fibrillation.

  American heart journal 19930401

• A comparison of the pharmacokinetic and pharmacodynamic properties of quinine and quinidine in healthy Thai males.

  British journal of clinical pharmacology 19930301

• Precordial QT interval dispersion as a marker of torsade de pointes. Disparate effects of class Ia antiarrhythmic drugs and amiodarone.

  Circulation 19921101

• Assessment of the efficacy and safety of antiarrhythmic therapy for chronic atrial fibrillation: observations on the role of trial design and implications of drug-related mortality.

  American heart journal 19921001

• Quinidine-induced uveitis.

  Israel journal of medical sciences 19921001

• A randomized double-blind crossover study comparing the efficacy and tolerability of flecainide and quinidine in the control of patients with symptomatic paroxysmal atrial fibrillation.

  American heart journal 19920901

• Flecainide in quinidine-resistant atrial fibrillation.

  The American journal of cardiology 19920820

• Autoantibodies associated with lupus induced by diverse drugs target a similar epitope in the (H2A-H2B)-DNA complex.

  The Journal of clinical investigation 19920701

• Characterization of multiple quinine-dependent antibodies in a patient with episodic hemolytic uremic syndrome and immune agranulocytosis.

  Blood 19920701

• Hemodynamic effects of quinidine and famotidine in patients with congestive heart failure.

  Clinical pharmacology and therapeutics 19920301

• Time-, voltage-, and state-dependent block by quinidine of a cloned human cardiac potassium channel.

  Molecular pharmacology 19920201

• Torsades de pointes and ventricular fibrillation in a canine model of quinidine-induced QT prolongation.

  Annals of the New York Academy of Sciences 19920127

• [Clinical effectiveness and potential hazards of combined kordaron and quinidine therapy of patients with atrial fibrillation].

  Klinicheskaia meditsina 19920101

• Propafenone-induced torsade de pointes: cross-reactivity with quinidine.

  Pacing and clinical electrophysiology : PACE 19911101

• Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes.

  Cancer research 19911001

• Usefulness of the electrophysiology laboratory for evaluation of proarrhythmic drug response in coronary artery disease.

  The American journal of cardiology 19910415

• Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae.

  Biochemistry 19901225

• Nonlinear dynamic analysis of temporally heterogeneous action potential characteristics.

  Pacing and clinical electrophysiology : PACE 19901201

• Quinidine/quinine: stereospecific electrophysiologic and antiarrhythmic effects in a canine model of ventricular tachycardia.

  Journal of cardiovascular pharmacology 19901101

• Alteration of propranolol pharmacokinetics and pharmacodynamics by quinidine in man.

  Journal of pharmacobio-dynamics 19901101

• Suppression of repolarization-related arrhythmias in vitro and in vivo by low-dose potassium channel activators.

  Circulation 19901001

• Comparison of the effects of intravenous LNC-834, a new antiarrhythmic agent, and quinidine in canine models of arrhythmia.

  Journal of cardiovascular pharmacology 19900901

• Erythromycin-induced long QT syndrome: concordance with quinidine and underlying cellular electrophysiologic mechanism.

  The American journal of medicine 19900801

• A functional psychosis precipitated by quinidine.

  The Medical journal of Australia 19900702

• [Torsade de pointes induced by quinidine: a case treated successfully with verapamil].

  Giornale italiano di cardiologia 19900501

• Synthesis and cardiac electrophysiological activity of aryl-substituted derivatives of the class III antiarrhythmic agent sematilide. Potential class I/III agents.

  Journal of medicinal chemistry 19900201

• [Quinidine-induced syncope--an example of the arrhythmogenic effect of anti-arrhythmia agents].

  Zeitschrift fur arztliche Fortbildung 19900101

• [Fatal thrombocytopenia triggered by quinidine].

  Ugeskrift for laeger 19891009

• [Ventricular fibrillation caused by the combined administration of amiodarone and quinidine].

  Kardiologiia 19890701

• Class I antiarrhythmic drug receptor: biochemical evidence for state-dependent interaction with quinidine and lidocaine.

  Molecular pharmacology 19890701

• Broad sensitivity of rodent arrhythmia models to class I, II, III, and IV antiarrhythmic agents.

  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19890601

• Selective killing of human T cell lymphotropic virus type I-transformed cell lines by a damavaricin Fc derivative.

  The Journal of antibiotics 19890501

• An unusual photoactivated skin eruption. Quinidine-induced livedo reticularis.

  Archives of dermatology 19890301

• A canine model of torsades de pointes.

  Pacing and clinical electrophysiology : PACE 19881201

• Quinidine: an update on therapeutics, pharmacokinetics and serum concentration monitoring.

  The American journal of cardiology 19881103

• Clinical characteristics of patients with ventricular fibrillation during antiarrhythmic drug therapy.

  The New England journal of medicine 19880804

• 'Quinidine syncope' without lengthening of Q-Tc interval in the presence of left bundle branch block. Role of programmed ventricular stimulation studies.

  Chest 19880701

• Plasma concentrations of quinidine, its major metabolites, and dihydroquinidine in patients with torsades de pointes.

  Clinical pharmacology and therapeutics 19880601

• Quinidine phenylethylbarbiturate-induced fulminant hepatitis in a pregnant woman. A case report.

  Journal of hepatology 19880401

• Quinidine-induced allergic granulomatous angiitis: an unusual cause of acute renal failure.

  The Medical journal of Australia 19880201

• Quinidine attenuates sympathetically induced poststenotic myocardial ischemia.

  Journal of cardiovascular pharmacology 19871201

• Comparative efficacy and safety of oral mexiletine and quinidine in benign or potentially lethal ventricular arrhythmias.

  The American journal of cardiology 19871201

• Intermittent fascicular extrasystoles producing pseudo AV block: electrophysiologic effects of beta agonists and antagonists.

  Pacing and clinical electrophysiology : PACE 19870901

• Enhanced antiarrhythmic efficacy of propafenone when used in combination with procainamide or quinidine.

  American heart journal 19870901

• Quinidine-induced torsade de pointes suppressed by paroxysmal atrial fibrillation.

  International journal of cardiology 19870901

• Efficacy of nadolol in preventing supraventricular tachycardia after coronary artery bypass grafting.

  The American journal of cardiology 19870831

• Quinidine syncope in children.

  Journal of the American College of Cardiology 19870501

• Orthostatic hypotension due to quinidine and atenolol.

  The American journal of medicine 19870501

• Skeletal muscle weakness resulting from quinidine ingestion.

  Southern medical journal 19870301

• Proarrhythmic effects of antiarrhythmic drugs during programmed ventricular stimulation in patients without ventricular tachycardia.

  Journal of the American College of Cardiology 19870201

• Orthostatic hypotension due to quinidine and propranolol.

  The American journal of medicine 19861201

• Clinical features and basic mechanisms of quinidine-induced arrhythmias.

  Journal of the American College of Cardiology 19860701

• Epicardial activation patterns of torsade de pointes in canine hearts with quinidine-induced long QT interval but without myocardial infarction.

  American heart journal 19860601

• Incidence and clinical features of the quinidine-associated long QT syndrome: implications for patient care.

  American heart journal 19860601

• Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death.

  Research communications in chemical pathology and pharmacology 19860301

• [Hepatitis caused by quinidine. Study of a case and review of the literature].

  Gastroenterologie clinique et biologique 19860301

• Quinidine-induced hepatitis. A common and reversible hypersensitivity reaction.

  Archives of internal medicine 19860301

• Central action of beta-adrenoceptor antagonists on blood pressure after acute administration in rats.

  Journal de pharmacologie 19860101

• Use of amiodarone in the treatment of persistent and paroxysmal atrial fibrillation resistant to quinidine therapy.

  Journal of the American College of Cardiology 19851201

• A new model of ventricular fibrillation induced by isoprenaline and catechol-O-methyl transferase inhibitor at a high perfusion temperature in isolated rat hearts.

  Journal of pharmacological methods 19851201

• Quinidine-induced vasculitis.

  Archives of internal medicine 19851101

• Quinidine-induced nephrotic syndrome.

  Journal of the National Medical Association 19851101

• Inhomogeneity of ventricular refractory period in canine heart with quinidine-induced long QT interval: a comparative study on effects of heart rate, isoprenaline, and lignocaine.

  Cardiovascular research 19851001

• Effects of bretylium tosylate on inhomogeneity of refractoriness and ventricular fibrillation threshold in canine hearts with quinidine-induced long QT interval.

  Cardiovascular research 19851001

• Torsade de pointes induced by sotalol.

  British medical journal (Clinical research ed.) 19850824

• Quinidine-induced photosensitive livedo reticularis-like eruption.

  Journal of the American Academy of Dermatology 19850201

• Mexiletine: long-term follow-up of a patient with prolonged QT interval and quinidine-induced torsades de pointes.

  Southern medical journal 19850201

• Drug-induced torsade de pointes.

  Clinical pharmacy 19850101

• Evidence supporting 3(S)-3-hydroxyquinidine-associated cardiotoxicity.

  Therapeutic drug monitoring 19850101

• Facilitation of ventricular tachyarrhythmia induction by isoproterenol.

  The American journal of cardiology 19841001

• Sotalol-induced prolongation of the Q-T interval and attacks of unconsciousness.

  International journal of clinical pharmacology, therapy, and toxicology 19840901

• Effect of some beta adrenergic blocking agents and phenytoin on potentiation of quinidine antiarrhythmic activity in the mouse.

  Archives internationales de pharmacodynamie et de therapie 19840701

• Unusual hepatotoxic reaction to quinidine.

  Canadian Medical Association journal 19840415

• Torsade de pointes due to quinidine: observations in 31 patients.

  American heart journal 19840301

• Magnesium therapy for torsades de pointes.

  The American journal of cardiology 19840201

• Antiarrhythmic drugs: a possible cause of out-of-hospital cardiac arrest.

  The New England journal of medicine 19831124

• Drug interactions with amiodarone.

  American heart journal 19831001

• Use of heart cell cultures as a tool for the evaluation of halothane arrhythmia.

  Toxicology and applied pharmacology 19830915

• 1-[4-(2-ter-butyl-quinolyl)]-3-(4-piperidyl)propanol (PK 10139): a new potent and long-acting antiarrhythmic agent.

  The Journal of pharmacology and experimental therapeutics 19830401

• [The anti-arrhythmia drug quinidine as an alternative in the treatment of severe falciparum malaria].

  Schweizerische medizinische Wochenschrift 19830219

• Quinidine-induced syncope.

  Archives of internal medicine 19830201

• [Anti-arrhythmia properties of pyromecaine].

  Farmakologiia i toksikologiia 19830101

• The response to procainamide during electrophysiologic study for sustained ventricular tachyarrhythmias predicts the response to other medications.

  Circulation 19830101

• [Comparative study of the activity of anti-arrhythmia agents in calcium chloride-induced arrhythmia in mice].

  Farmakologiia i toksikologiia 19830101

• Sinoatrial arrest due to lidocaine injection in sick sinus syndrome during amiodarone administration.

  American heart journal 19821201

• [Harmful interactions of amiodarone and class I anti-arrhythmia agents].

  Schweizerische medizinische Wochenschrift 19821106

• Mechanism of action of quinidine on heart rate in the dog.

  The Journal of pharmacology and experimental therapeutics 19820901

• Torsades de pointes, a common arrhythmia, induced by medication.

  Canadian Medical Association journal 19820901

• Dangerous interaction between amiodarone and quinidine.

  Lancet (London, England) 19820612

• [Atypical ventricular tachycardia due to disopyramide].

  Harefuah 19820315

• Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.

  Chest 19820301

• Cardiovascular effects of quinidine and procainamide on intact dogs and isolated cross-perfused canine atria.

  Journal of cardiovascular pharmacology 19820101

• Visual disturbances associated with quinidine and quinine.

  Neurology 19811201

• Does physostigmine reverse quinidine delirium?

  The Western journal of medicine 19811101

• Multiform quinidine toxicity.

  Southern medical journal 19811001

• Verapamil: its potential for causing serious complications in patients with hypertrophic cardiomyopathy.

  Circulation 19810901

• Digoxin retinal toxicity. Clinical and electrophysiological evaluation of a cone dysfunction syndrome.

  Archives of ophthalmology (Chicago, Ill. : 1960) 19810901

• Torsade de pointes ventricular tachycardia. A complication of disopyramide shared with quinidine.

  Journal of electrocardiology 19810701

• Ventricular tachyarrhythmias induced by disopyramide and other similar anti-arrhythmic drugs.

  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 19810606

• Disopyramide-induced Torsade de Pointes.

  Archives of internal medicine 19810601

• Synthesis and antiarrhythmic activity of new benzofuran derivatives.

  Journal of medicinal chemistry 19810201

• Ventricular pacing in atypical ventricular tachycardia.

  Journal of electrocardiology 19810101

• Quinidine therapy and digitalis toxicity.

  Journal of the American Geriatrics Society 19810101

• Open clinical studies at a referral center: chronic maintenance tocainide therapy in patients with recurrent sustained ventricular tachycardia refractory to conventional antiarrhythmic agents.

  American heart journal 19801201

• Hepatosplenomegaly as a manifestation of quinidine hypersensitivity.

  Age and ageing 19801101

• [Sudden arrest of respiration and attacks of syncope induced by small dose of quinidine--report of the clinical data of 6 cases (author's transl)].

  Zhonghua nei ke za zhi 19801101

• Overdrive pacing in quinidine syncope and other long QT-interval syndromes.

  Archives of internal medicine 19800801

• [Paradoxic response to disopyramide and quinidine (author's transl)].

  Zeitschrift fur Kardiologie 19800801

• Granulomatous hepatitis as a manifestation of quinidine hypersensitivity.

  Archives of internal medicine 19800301

• Henoch-Schönlein syndrome associated with quinidine.

  JAMA 19800201

• Prodromal ventricular premature beats preceded by a diastolic wave.

  Acta medica Scandinavica 19800101

• Antiarrhythmic activity of dextro- and levo-isomers of 5-methyl-8-(2-hydroxy-3-t-butylamino-propoxy) coumarin hydrocholoride (bucumolol), a beta-adrenergic blocking agent, on aconitine-induced atrial and ouabain-induced ventricular arrhythmias in dogs.

  Japanese journal of pharmacology 19791201

• Pharmacokinetics of dihydroquinidine in congestive heart failure patients after intravenous quinidine administration.

  European journal of clinical pharmacology 19790901

• Bretylium tosylate: a newly available antiarrhythmic drug for ventricular arrhythmias.

  Annals of internal medicine 19790801

• Disopyramide-induced syncope.

  The American journal of cardiology 19790801

• Lymphocyte transformation studies in drug hypersensitivity.

  Canadian Medical Association journal 19790505

• Disopyramide-induced ventricular fibrillation.

  The American journal of cardiology 19790501

• Immune hemolytic anemia and thrombocytopenia secondary to quinidine: in vitro studies of the quinidine-dependent red cell and platelet antibodies.

  Blood 19790301

• Trigeminal neuralgia from digitalis intoxication.

  JAMA 19790112

• Problems raised by a complex arrhythmia following quinidine cardioversion of an atrial fibrillation.

  Medecine interne 19790101

• Atypical ventricular tachycardia as a manifestation of disopyramide toxicity.

  The American journal of cardiology 19781201

• Right ventricular monophasic action potentials in patients with long QT syndrome.

  British heart journal 19780901

• Successful treatment by overdrive pacing of recurrent quinidine syncope due to ventricular tachycardia.

  The American journal of medicine 19780401

• Peripheral neuropathy with disopyramide.

  Lancet (London, England) 19780211

• Disopyramide in myocardial infarction.

  Lancet (London, England) 19780211

• Ventricular tachycardia-flutter associated with disopyramide therapy: a report of three cases.

  Heart & lung : the journal of critical care 19780101

• Quinidine-induced hemolytic anemia: immunohematologic characterization.

  Transfusion 19780101

• [Clinical death in an attempt at sinus rhythm restoration with quinidine in auricular fibrillation].

  Vutreshni bolesti 19780101

• Adverse reactions to practolol in hospitalized patients: a report from the Boston Collaborative Drug Surveillance Program.

  European journal of clinical pharmacology 19771114

• Quinidine dementia.

  JAMA 19770509

• Drug-induced anaphylaxis, convulsions, deafness, and extrapyramidal symptoms.

  Lancet (London, England) 19770312

• Drug-induced lupus erythematosus.

  Arizona medicine 19770301

• Adverse reactions to quinidine in hospitalized patients: findings based on data from the Boston Collaborative Drug Surveillance Program.

  Progress in cardiovascular diseases 19770101

• Use of glucagon in the treatment of quinidine toxicity in the heart.

  Cardiovascular research 19770101

• Quinidine syncope: torsade de pointes with low quinidine plasma concentrations.

  European journal of cardiology 19761201

• Quinidine-induced ventricular flutter and fibrillation without digitalis therapy.

  The American journal of cardiology 19761001

• Quinidine syncope. A report of successful treatment with bretylium tosylate.

  The Journal of thoracic and cardiovascular surgery 19760901

• Quinidine-induced lupus nephritis.

  JAMA 19760503

• Quinidine hypersensitivity and liver involvement. A survey of 32 patients.

  Gastroenterology 19760501

• Use of cardioactive drugs in acute myocardial infarction.

  Heart & lung : the journal of critical care 19760101

• Mechanism of action of quinidine on squid axon membranes.

  The Journal of pharmacology and experimental therapeutics 19760101

• Quinidine hepatitis.

  Archives of internal medicine 19750601

• Drug-induced haemolytic anemia.

  Clinics in haematology 19750201

• Hydroxyzine hydrochloride: possible adverse cardiac interactions.

  Psychopharmacology communications 19750101

• Method for the production of severe ventricular dysrhythmias in small laboratory animals.

  Recent advances in studies on cardiac structure and metabolism 19750101

• Quinidine-induced granulomatous hepatitis.

  Annals of internal medicine 19741201

• Effect of procaine amide, quinidine, and ajmaline in the Wolff-Parkinson-White syndrome.

  Circulation 19740701

• Fluorescence of 6-methoxyquinoline, quinine, and quinidine in aqueous media.

  Journal of pharmaceutical sciences 19740601

• Antiarrhythmic drug therapy for sporadic ventricular ectopic arrhythmias.

  Circulation 19740401

• A comparison of the experimental anti-arrhythmic properties of acebutolol (M and B 17,803), propranolol and practolol.

  British journal of pharmacology 19740301

• Photosensitive livedo reticularis.

  Archives of dermatology 19730701

• Drug-induced deafness.

  JAMA 19730423

• Quinidine hemolytic anemia in the absence of thrombocytopenia in a patient with hemoglobin D.

  Transfusion 19730301

• Cardiovascular effects of a newer antiarrhythmic agent, disopyramide phosphate.

  American heart journal 19721201

• Quinidine syncope; report of a case successfully treated with lidocaine.

  Chest 19721201

• Quinidine-induced liver disease.

  Annals of internal medicine 19721001

• Treatment of ventricular tachycardia in an infant.

  Canadian Medical Association journal 19720722

• Sinoatrial arrest due to lidocaine in a patient receiving guinidine.

  Chest 19720601

• Sino-atrial block in man provoked by quinidine.

  Journal of electrocardiology 19720101

• Possible quinidine-induced hemorrhage in a patient on warfarin sodium.

  The New England journal of medicine 19690327

• Recurrent ventricular fibrillation precipitated by quinidine. Report of a patient with recovery after 28 paroxysms.

  Archives of internal medicine 19680701

• Antiarrhythmic activity of some isoquinoline derivatives determined by a rapid screening procedure in the mouse.

  The Journal of pharmacology and experimental therapeutics 19680301

• [Comparative antiarrhythmic and antitoxic activity of beta-hexamethyleneimino-para-butoxypropiophenone, novocaine amide and quinidine in arrhythmia, induced by calcium chlorides in mice].

  Farmakologiia i toksikologiia 19680101

• Quinidine-sulfate-induced hypoplastic anemia and agranulocytosis.

  JAMA 19670731

• Quinidine-induced tachycardia in dogs with bundle branch block.

  The Journal of pharmacology and experimental therapeutics 19660901

• Quinidine-induced paroxysmal ventricular fibrillation treated with propranolol.

  British medical journal 19660618

• The effect of diphenylhydantoin sodium (dilantin), procaine hydrochloride, procaine amide hydrochloride, and quinidine hydrochloride upon ouabain-induced ventricular tachycardia in unanesthetized dogs.

  Circulation 19540701