56-89-3 | L-Cystine

Packsize	Purity	Availability	Price	Discounted Price
25g	98%	in stock	$12.00	$9.00
100g	98%	in stock	$24.00	$17.00
500g	98%	in stock	$50.00	$35.00

Description

• Catalog Number: AB75076
• Chemical Name: L-Cystine
• CAS Number: 56-89-3
• Molecular Formula: C6H12N2O4S2
• Molecular Weight: 240.3005
• MDL Number: MFCD00064228
• SMILES: NC(C(=O)O)CSSC[C@@H](C(=O)O)N

Computed Properties

• Complexity: 192
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 7
• XLogP3: -6.3

Upstream Synthesis Route

L-Cystine is a valuable amino acid that plays a crucial role in chemical synthesis processes. In the realm of chemistry, L-Cystine is frequently utilized for its ability to form disulfide bonds. These bonds can impart structural stability and strength to various compounds, making L-Cystine a key component in the manufacturing of pharmaceuticals, cosmetics, and food additives. Additionally, L-Cystine is employed in the creation of novel materials, such as polymers and nanoparticles, due to its unique chemical properties. Its versatility and reactivity make L-Cystine a versatile tool for chemists seeking to develop innovative products and materials.

Literature

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• A phase I study of imexon plus gemcitabine as first-line therapy for advanced pancreatic cancer.

  Cancer chemotherapy and pharmacology 20100701

• Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc- as a neuroprotective drug target.

  CNS & neurological disorders drug targets 20100701

• Analysis of 24-hour urine parameters as it relates to age of onset of cystine stone formation.

  Journal of endourology 20100701

• Development of a rapid and sensitive method for determination of cysteine/cystine ratio in chemically defined media.

  Journal of chromatography. A 20100611

• Oxidation of plasma cysteine/cystine and GSH/GSSG redox potentials by acetaminophen and sulfur amino acid insufficiency in humans.

  The Journal of pharmacology and experimental therapeutics 20100601

• Growth retardation in children with cystinosis.

  Minerva pediatrica 20100601

• Downregulation of cystine transporter xc by irinotecan in human head and neck cancer FaDu xenografts.

  Chemotherapy 20100601

• Features of a spatially constrained cystine loop in the p10 FAST protein ectodomain define a new class of viral fusion peptides.

  The Journal of biological chemistry 20100528

• Cystine 186-cystine 209 disulfide bond is not essential for the procoagulant activity of tissue factor or for its de-encryption.

  Blood 20100527

• Synthesis of unnatural selenocystines and beta-aminodiselenides via regioselective ring-opening of sulfamidates using a sequential, one-pot, multistep strategy.

  The Journal of organic chemistry 20100507

• Long-term treatment of cystinosis in children with twice-daily cysteamine.

  The Journal of pediatrics 20100501

• Local hindlimb antioxidant infusion does not affect muscle glucose uptake during in situ contractions in rat.

  Journal of applied physiology (Bethesda, Md. : 1985) 20100501

• N-Acetylcysteine infusion does not affect glucose disposal during prolonged moderate-intensity exercise in humans.

  The Journal of physiology 20100501

• The pleiotropic CymR regulator of Staphylococcus aureus plays an important role in virulence and stress response.

  PLoS pathogens 20100501

• Structure-activity relationships in toll-like receptor-2 agonistic diacylthioglycerol lipopeptides.

  Journal of medicinal chemistry 20100422

• Fertility status in male cystinosis patients treated with cysteamine.

  Fertility and sterility 20100401

• Cysteine, thiourea and thiocyanate interactions with clays: FT-IR, Mössbauer and EPR spectroscopy and X-ray diffractometry studies.

  Amino acids 20100401

• Renal phenotype of the cystinosis mouse model is dependent upon genetic background.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100401

• Arsenic accumulation and thiol status in lichens exposed to As(V) in controlled conditions.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20100401

• Mouse cumulus-denuded oocytes restore developmental capacity completely when matured with optimal supplementation of cysteamine, cystine, and cumulus cells.

  Biology of reproduction 20100401

• Inhibition of apoptotic signalling in spermine-treated vascular smooth muscle cells by a novel glutathione precursor.

  Cell biology international 20100401

• Lactacidosis modulates glutathione metabolism and oxidative glutamate toxicity.

  Journal of neurochemistry 20100401

• Site-specific effects of diselenide bridges on the oxidative folding of a cystine knot peptide, omega-selenoconotoxin GVIA.

  Biochemistry 20100330

• Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines.

  The Journal of pharmacology and experimental therapeutics 20100301

• Potential mechanisms involved in the absorptive transport of cadmium in isolated perfused rabbit renal proximal tubules.

  Toxicology letters 20100301

• Analysis of 13Calpha and 13Cbeta chemical shifts of cysteine and cystine residues in proteins: a quantum chemical approach.

  Journal of biomolecular NMR 20100301

• Cystine and theanine supplementation restores high-intensity resistance exercise-induced attenuation of natural killer cell activity in well-trained men.

  Journal of strength and conditioning research 20100301

• 'Relaxers' damage hair: evidence from amino acid analysis.

  Journal of the American Academy of Dermatology 20100301

• Commentary: healthy hair and protein loss.

  Journal of the American Academy of Dermatology 20100301

• Antioxidant micronutrients and biomarkers of oxidative stress and inflammation in colorectal adenoma patients: results from a randomized, controlled clinical trial.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20100301

• Formation of pyrazines in Maillard model systems of lysine-containing dipeptides.

  Journal of agricultural and food chemistry 20100224

• Small-molecule diselenides catalyze oxidative protein folding in vivo.

  ACS chemical biology 20100219

• Cysteine and glutathione mixed-disulfide conjugates of thiosulfinates: chemical synthesis and biological activities.

  Journal of agricultural and food chemistry 20100210

• Developmental changes in cerebral white matter microstructure in a disorder of lysosomal storage.

  Cortex; a journal devoted to the study of the nervous system and behavior 20100201

• A novel murine model for chronic inflammatory alveolar bone loss.

  Journal of periodontal research 20100201

• Combined administration of (L)-cystine and (L)-theanine enhances immune functions and protects against influenza virus infection in aged mice.

  The Journal of veterinary medical science 20100201

• The DC gate in Channelrhodopsin-2: crucial hydrogen bonding interaction between C128 and D156.

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20100201

• Potent homocysteine-induced ERK phosphorylation in cultured neurons depends on self-sensitization via system Xc(-).

  Toxicology and applied pharmacology 20100115

• A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential.

  Free radical biology & medicine 20100115

• Evaluation of trends in urolith composition and characteristics of dogs with urolithiasis: 25,499 cases (1985-2006).

  Journal of the American Veterinary Medical Association 20100115

• Polarized spectroscopic elucidation of N-acetyl-L-cysteine, L-cysteine, L-cystine, L-ascorbic acid and a tool for their determination in solid mixtures.

  Amino acids 20100101

• Self-assembling and auto-crosslinkable hyaluronic acid hydrogels with a fibrillar structure.

  Acta biomaterialia 20100101

• Lupin protein isolate and cysteine-supplemented casein reduce calcification of atherosclerotic lesions in apoE-deficient mice.

  The British journal of nutrition 20100101

• Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking.

  Biological psychiatry 20100101

• Identification of human calculi with time-of-flight secondary ion mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20100101

• Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine.

  Cancer research 20100101

• Non-type I cystinuria associated with mental retardation and ataxia in a Korean boy with a new missence mutation(G173R) in the SLC7A9 gene.

  Journal of Korean medical science 20100101

• Comparison of the effects on lipid metabolism of dietary methionine and cystine between hepatoma-bearing and normal rats.

  Bioscience, biotechnology, and biochemistry 20100101

• Technetium-99m ethyl cysteinate dimer (ECD) cerebral accumulation and symptom and sign severity during hypothyroidism.

  Neuro endocrinology letters 20100101

• Oxpholipin 11D: an anti-inflammatory peptide that binds cholesterol and oxidized phospholipids.

  PloS one 20100101

• Amino acid accumulation limits the overexpression of proteins in Lactococcus lactis.

  PloS one 20100101

• Evaluation of nondigested carbohydrates in hydroxypropylated tapioca starch.

  Journal of food science 20100101

• An update and practical guide to renal stone management.

  Nephron. Clinical practice 20100101

• Effects of simultaneous dietary fish oil ingestion and sulfur amino acid supplementation on the lipid metabolism in hepatoma-bearing rats with hyperlipidemia.

  Journal of nutritional science and vitaminology 20100101

• Expression and RNA interference of salivary polygalacturonase genes in the tarnished plant bug, Lygus lineolaris.

  Journal of insect science (Online) 20100101

• Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women.

  PloS one 20100101

• Perfluorooctanoic acid for shotgun proteomics.

  PloS one 20100101

• Regulation of interleukin-4 signaling by extracellular reduction of intramolecular disulfides.

  Biochemical and biophysical research communications 20091225

• Molecularly defined antibody conjugation through a selenocysteine interface.

  Biochemistry 20091222

• Multiple screening of urolithic organic acids with copper nanoparticle-plated electrode: potential assessment of urolithic risks.

  Analytical biochemistry 20091215

• Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species.

  The Biochemical journal 20091210

• Time before isolating cystinotic leukocytes affects reliability of cystine determination.

  Pediatric nephrology (Berlin, Germany) 20091201

• Cysteamine prevents inhibition of adenylate kinase caused by cystine in rat brain cortex.

  Metabolic brain disease 20091201

• Trichothiodystrophy and fragile hair: the distinction between diagnostic signs and diagnostic labels in childhood hair disease.

  The British journal of dermatology 20091201

• A dual pressure linear ion trap Orbitrap instrument with very high sequencing speed.

  Molecular & cellular proteomics : MCP 20091201

• Quiz page. Fanconi syndrome caused by cystinosis, intermediate type.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20091201

• Nicotinic receptor ligands reduce ethanol intake by high alcohol-drinking HAD-2 rats.

  Alcohol (Fayetteville, N.Y.) 20091201

• The platelet receptor CLEC-2 is active as a dimer.

  Biochemistry 20091124

• Identification of specific transmembrane residues and ligand-induced interface changes involved in homo-dimer formation of a yeast G protein-coupled receptor.

  Biochemistry 20091124

• Measuring the poise of thiol/disulfide couples in vivo.

  Free radical biology & medicine 20091115

• Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity.

  Proteins 20091101

• Investigating the influences of redox buffer compositions on the amyloid fibrillogenesis of hen egg-white lysozyme.

  Biochimica et biophysica acta 20091101

• Electrochemical oxidation of selenocystine and selenomethionine.

  Colloids and surfaces. B, Biointerfaces 20091101

• In vitro radioprotection studies of organoselenium compounds: differences between mono- and diselenides.

  Radiation and environmental biophysics 20091101

• High-dose cysteine administration does not increase synthesis of the antioxidant glutathione preterm infants.

  Pediatrics 20091101

• The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.

  Bioorganic & medicinal chemistry 20091015

• Facile syntheses of L-beta-haloalanine derivatives from L-cysteine or L-cystine.

  Amino acids 20091001

• Estimation of urinary stone composition by automated processing of CT images.

  Urological research 20091001

• Extracellular redox modulation by regulatory T cells.

  Nature chemical biology 20091001

• Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions.

  The Biochemical journal 20090925

• Cystinosis of the brain and spinal cord with associated vasculopathy.

  Journal of the neurological sciences 20090915

• Gemini surfactant-protein interactions: effect of pH, temperature, and surfactant stereochemistry.

  Biomacromolecules 20090914

• Evaluation of treatment with cysteamine eyedrops for cystinosis with confocal microscopy.

  Cornea 20090901

• Cysteamine prevents inhibition of adenylate kinase caused by cystine in rat brain cortex.

  Metabolic brain disease 20090901

• [Fluorescence analysis of trace glucose using glucose oxidase and horseradish peroxidase].

  Guang pu xue yu guang pu fen xi = Guang pu 20090901

• Burn injury induces the expression of cystine/glutamate transporter (x(c)(-)) in mouse T cells.

  Immunology letters 20090815

• The xc- cystine/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: use of sulfasalazine.

  Cancer chemotherapy and pharmacology 20090801

• The x(c)(-) cystine/glutamate antiporter (xCT) as a potential target for therapy of cancer: yet another cytotoxic anticancer approach?

  Journal of cellular physiology 20090801

• Stereoselective HDAC inhibition from cysteine-derived zinc-binding groups.

  ChemMedChem 20090801

• Oxidation of bovine serum albumin: identification of oxidation products and structural modifications.

  Rapid communications in mass spectrometry : RCM 20090801

• Current medical aspects of pantethine.

  Ideggyogyaszati szemle 20090730

• Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle.

  The Journal of biological chemistry 20090724

• Use of the design-of-experiments approach for the development of a refolding technology for progenipoietin-1, a recombinant human cytokine fusion protein from Escherichia coli inclusion bodies.

  Biotechnology and applied biochemistry 20090714

• No selenium required: reactions catalyzed by mammalian thioredoxin reductase that are independent of a selenocysteine residue.

  Biochemistry 20090707

• CymR, the master regulator of cysteine metabolism in Staphylococcus aureus, controls host sulphur source utilization and plays a role in biofilm formation.

  Molecular microbiology 20090701

• Elucidating conformational changes in the gamma-aminobutyric acid transporter-1.

  The Journal of biological chemistry 20090612

• Cystine accumulation in the CNS results in severe age-related memory deficits.

  Neurobiology of aging 20090601

• Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine.

  Chest 20090601

• Laser capture microscopy in a study of expression of structural proteins in the cuticle cells of human hair.

  Experimental dermatology 20090601

• beta-N-methylamino-l-alanine induces oxidative stress and glutamate release through action on system Xc(-).

  Experimental neurology 20090601

• Theoretical and experimental sulfur K-edge X-ray absorption spectroscopic study of cysteine, cystine, homocysteine, penicillamine, methionine and methionine sulfoxide.

  Dalton transactions (Cambridge, England : 2003) 20090514

• Evidence for durable kidney stone prevention over several decades.

  BJU international 20090501

• Study of the oxidation dynamics of ethyl cysteinate dimer in solution by ultra-performance liquid chromatography with tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20090501

• In vivo confocal microscopy and anterior segment optical coherence tomography analysis of the cornea in nephropathic cystinosis.

  Ophthalmology 20090501

• Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia.

  Progress in neuro-psychopharmacology & biological psychiatry 20090430

• Effects of oral supplementation with cystine and theanine on the immune function of athletes in endurance exercise: randomized, double-blind, placebo-controlled trial.

  Bioscience, biotechnology, and biochemistry 20090423

• Molecular evolution of cystine-stabilized miniproteins as stable proteinaceous binders.

  Structure (London, England : 1993) 20090415

• Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator.

  Journal of structural biology 20090401

• Pseudo-merohedral twinning in monoclinic crystals of wild-type human brain neuroglobin.

  Acta crystallographica. Section D, Biological crystallography 20090401

• SPECT and PET imaging of EGF receptors with site-specifically labeled EGF and dimeric EGF.

  Bioconjugate chemistry 20090401

• Methionine+cystine requirement of broiler chickens fed low-density diets under tropical conditions.

  Tropical animal health and production 20090301

• Selenocystine induces caspase-independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species generation.

  The international journal of biochemistry & cell biology 20090301

• Interactions of the M. tuberculosis UsfX with the cognate sigma factor SigF and the anti-anti sigma factor RsfA.

  Biochimica et biophysica acta 20090301

• Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members.

  Brain : a journal of neurology 20090301

• Comparative evaluation of Tc-99m cystine and Tc-99m MAG3 in normals and patients with renal functional impairment.

  Clinical nuclear medicine 20090301

• The role of copper in cysteine oxidation: study of intra- and inter-molecular reactions in mass spectrometry.

  Metallomics : integrated biometal science 20090301

• Computational model of extracellular glutamate in the nucleus accumbens incorporates neuroadaptations by chronic cocaine.

  Neuroscience 20090218

• Characteristics of transport of selenoamino acids by epithelial amino acid transporters.

  Chemico-biological interactions 20090212

• Selenocystine induces reactive oxygen species-mediated apoptosis in human cancer cells.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20090201

• HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway.

  Toxicological sciences : an official journal of the Society of Toxicology 20090201

• Improved identification of endogenous peptides from murine nervous tissue by multiplexed peptide extraction methods and multiplexed mass spectrometric analysis.

  Journal of proteome research 20090201

• N,N'-Bis(5-aminosalicyl)-L-cystine is a potential colon-specific 5-aminosalicylic acid prodrug with dual therapeutic effects in experimental colitis.

  Journal of pharmaceutical sciences 20090101

• Oxidation of plasma cysteine/cystine redox state in endotoxin-induced lung injury.

  American journal of respiratory cell and molecular biology 20090101

• Oxidation of extracellular cysteine/cystine redox state in bleomycin-induced lung fibrosis.

  American journal of physiology. Lung cellular and molecular physiology 20090101

• Changing paradigms in diagnosis of inherited defects associated with urolithiasis.

  The Veterinary clinics of North America. Small animal practice 20090101

• Non-contact anterior segment OCT for corneal crystals in cystinosis.

  Journal of pediatric ophthalmology and strabismus 20090101

• Prolonged treatment with N-acetylcystine delays liver recovery from acetaminophen hepatotoxicity.

  Critical care (London, England) 20090101

• Intestinal barrier function in response to abundant or depleted mucosal glutathione in Salmonella-infected rats.

  BMC physiology 20090101

• Retrocyclin-2: a potent anti-HIV theta-defensin that forms a cyclic cystine ladder structural motif.

  Advances in experimental medicine and biology 20090101

• Role of N-acetylcysteine and cystine in glutathione synthesis in human erythrocytes.

  Redox report : communications in free radical research 20090101

• Intestinal redox status of major intracellular thiols in a rat model of chronic alcohol consumption.

  JPEN. Journal of parenteral and enteral nutrition 20090101

• [Hypothesis of biochemical mechanisms of kidney calculi formation].

  Urologiia (Moscow, Russia : 1999) 20090101

• Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation.

  BMC cell biology 20090101

• Enzymatic approach to analyze the effects of mercaptans on hair.

  Journal of cosmetic science 20090101

• Novel fluorescence molecular imaging of chemotherapy-induced intestinal apoptosis.

  Journal of biomedical optics 20090101

• Mechanisms of beta-N-methylamino-L-alanine induced neurotoxicity.

  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20090101

• Cystinosis, Fanconi syndrome, and odontogenic cysts.

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20081201

• Co-administration of l-cystine and l-theanine enhances efficacy of influenza vaccination in elderly persons: nutritional status-dependent immunogenicity.

  Geriatrics & gerontology international 20081201

• Reversible dynamic isomerism change in the solid state, from Bi4I16 clusters to BiI4 1D chains in L-cystine based hybrids: templating effect of cations in iodobismuthate network formation.

  Chemical communications (Cambridge, England) 20081130

• Selenocystine induces S-phase arrest and apoptosis in human breast adenocarcinoma MCF-7 cells by modulating ERK and Akt phosphorylation.

  Journal of agricultural and food chemistry 20081126

• Effect of fudosteine on mucin production.

  The European respiratory journal 20081101

• Is ascorbate able to reduce disulfide bridges? A cautionary note.

  Nitric oxide : biology and chemistry 20081101

• A novel approach to enhancing cellular glutathione levels.

  Journal of neurochemistry 20081101

• The three-fingered protein domain of the human genome.

  Cellular and molecular life sciences : CMLS 20081101

• Effect of dimethyl sulfides on the induction of apoptosis in human leukemia Jurkat cells and HL-60 cells.

  Bioscience, biotechnology, and biochemistry 20081101

• Clinicopathological features of ocular cystinosis.

  Clinical & experimental ophthalmology 20081101

• Urinary felinine excretion in intact male cats is increased by dietary cystine.

  The British journal of nutrition 20081001

• Production of bioactive human beta-defensin 5 and 6 in Escherichia coli by soluble fusion expression.

  Protein expression and purification 20081001

• A rapid LC-FTMS method for the analysis of cysteine, cystine and cysteine/cystine steady-state redox potential in human plasma.

  Clinica chimica acta; international journal of clinical chemistry 20081001

• Repeated exposure to cocaine alters the modulation of mesocorticolimbic glutamate transmission by medial prefrontal cortex Group II metabotropic glutamate receptors.

  Journal of neurochemistry 20081001

• Similar membrane affinity of mono- and Di-S-acylated ras membrane anchors: a new twist in the role of protein lipidation.

  Journal of the American Chemical Society 20080924

• Selenocystine induces apoptosis of A375 human melanoma cells by activating ROS-mediated mitochondrial pathway and p53 phosphorylation.

  Cellular and molecular life sciences : CMLS 20080901

• The undertow of sulfur metabolism on glutamatergic neurotransmission.

  Trends in biochemical sciences 20080901

• Nanoparticulate glutathione peroxidase mimics based on selenocystine-pullulan conjugates.

  Bioconjugate chemistry 20080901

• The photodimerization of a cinnamoyl moiety derivative in dilute solution based on the intramolecular chain interaction of gemini surfactant.

  The journal of physical chemistry. B 20080821

• Blunted cystine-glutamate antiporter function in the nucleus accumbens promotes cocaine-induced drug seeking.

  Neuroscience 20080813

• The xc- cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance.

  British journal of cancer 20080805

• Cyst(e)ine imbalance and its effect on methionine precursor utilization in chicks.

  Journal of animal science 20080801

• Acetazolamide is an effective adjunct for urinary alkalization in patients with uric acid and cystine stone formation recalcitrant to potassium citrate.

  Urology 20080801

• High-level expression and novel purification strategy of recombinant thanatin analog in Escherichia coli.

  Current microbiology 20080801

• Mutation in the cysteine bridge domain of the gamma-subunit affects light regulation of the ATP synthase but not photosynthesis or growth in Arabidopsis.

  Photosynthesis research 20080801

• Gene transfer may be preventive but not curative for a lysosomal transport disorder.

  Molecular therapy : the journal of the American Society of Gene Therapy 20080801

• The characterization of selected drugs with infrared laser desorption/tunable synchrotron vacuum ultraviolet photoionization mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20080801

• Peptide cysteine thiyl radicals abstract hydrogen atoms from surrounding amino acids: the photolysis of a cystine containing model peptide.

  The journal of physical chemistry. B 20080731

• Blockade of sensory abnormalities and kinin B(1) receptor expression by N-acetyl-L-cysteine and ramipril in a rat model of insulin resistance.

  European journal of pharmacology 20080728

• A novel HPLC-UV/nano-TiO2-chemiluminescence system for the determination of selenocystine and selenomethionine.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080715

• Identification of the major cysteine protease of Giardia and its role in encystation.

  The Journal of biological chemistry 20080627

• The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases.

  Journal of cellular physiology 20080601

• Cysteamine prevents inhibition of thiol-containing enzymes caused by cystine or cystine dimethylester loading in rat brain cortex.

  Metabolic brain disease 20080601

• Targeting cell death in vivo in experimental traumatic brain injury by a novel molecular probe.

  Journal of neurotrauma 20080601

• Conserved structural determinants in three-fingered protein domains.

  The FEBS journal 20080601

• [Cystine lithiasis: retrospective study about 25 cases].

  La Tunisie medicale 20080601

• Role of disulphide bonds in a thermophilic serine protease aqualysin I from Thermus aquaticus YT-1.

  Journal of biochemistry 20080501

• Active control of surface properties and aggregation behavior in amino acid-based Gemini surfactant systems.

  Journal of colloid and interface science 20080501

• Identification and subcellular localization of a new cystinosin isoform.

  American journal of physiology. Renal physiology 20080501

• High-throughput determination of fudosteine in human plasma by liquid chromatography-tandem mass spectrometry, following protein precipitation in the 96-well plate format.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080501

• The interactions between cysteamine, cystine and cumulus cells increase the intracellular glutathione level and developmental capacity of goat cumulus-denuded oocytes.

  Reproduction (Cambridge, England) 20080501

• Enzymatic degradation of keratin films and keratin fibers prepared from human hair.

  Biological & pharmaceutical bulletin 20080501

• Disulfide S-monoxides convert xanthine dehydrogenase into oxidase in rat liver cytosol more potently than their respective disulfides.

  Biological & pharmaceutical bulletin 20080501

• Reactive sulfur species: kinetics and mechanism of the equilibrium between cysteine sulfenyl thiocyanate and cysteine thiosulfinate ester in acidic aqueous solution.

  The Journal of organic chemistry 20080418

• Pulse radiolysis studies on reactions of hydroxyl radicals with selenocystine derivatives.

  The journal of physical chemistry. B 20080410

• A role for glutamate in growth and invasion of primary brain tumors.

  Journal of neurochemistry 20080401

• A cystine-cysteine shuttle mediated by xCT facilitates cellular responses to S-nitrosoalbumin.

  American journal of physiology. Cell physiology 20080401

• The cystine/cysteine cycle: a redox cycle regulating susceptibility versus resistance to cell death.

  Oncogene 20080306

• Cystinuria.

  Seminars in nephrology 20080301

• Comparative digestibility of amino acids of maize, sorghum, finger millet and pearl millet in cockerels and Japanese quails.

  British poultry science 20080301

• [Indirect determination of stability constant of zinc cystine chelate by flame atomic absorption spectrometry with ZnS].

  Guang pu xue yu guang pu fen xi = Guang pu 20080301

• Evaluation of cystine transport in cultured human kidney cells and establishment of cystinuria type I phenotype by antisense technology.

  Urological research 20080201

• Individual response of growing pigs to sulphur amino acid intake.

  Journal of animal physiology and animal nutrition 20080201

• Commentary: Sibling trials in Banbridge, County Down.

  International journal of epidemiology 20080201

• Disulfide bond-dependent mechanism of protection against oxidative stress in pyruvate-ferredoxin oxidoreductase of anaerobic Desulfovibrio bacteria.

  Biochemistry 20080122

• Bridging the gap between protein carboxyl methylation and phospholipid methylation to understand glucose-stimulated insulin secretion from the pancreatic beta cell.

  Biochemical pharmacology 20080115

• Ultra-stable peptide scaffolds for protein engineering-synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2.

  Chembiochem : a European journal of chemical biology 20080104

• The new oral immunomodulating drug DiNAC induces brachial artery vasodilatation at rest and during hyperemia in hypercholesterolemic subjects, likely by a nitric oxide-dependent mechanism.

  Atherosclerosis 20080101

• Natural and artificial cystine knots for assembly of homo- and heterotrimeric collagen models.

  Antioxidants & redox signaling 20080101

• Oxidative folding of cyclic cystine knot proteins.

  Antioxidants & redox signaling 20080101

• A prominent role for mucosal cystine/cysteine metabolism in intestinal immunoregulation.

  Gastroenterology 20080101

• Functional asymmetry of the conserved cystine loops in alphabetagamma GABA A receptors revealed by the response to GABA activation and drug potentiation.

  The international journal of biochemistry & cell biology 20080101

• Iron regulates L-cystine uptake and glutathione levels in lens epithelial and retinal pigment epithelial cells by its effect on cytosolic aconitase.

  Investigative ophthalmology & visual science 20080101

• Late-onset nephropathic cystinosis: clinical presentation, outcome, and genotyping.

  Clinical journal of the American Society of Nephrology : CJASN 20080101

• Use of inhaled heparin/N-acetylcystine in inhalation injury: does it help?

  Journal of burn care & research : official publication of the American Burn Association 20080101

• Synthesis and properties of N,N'-bis(5-aminosalicyl)-L-cystine as a colon-specific deliverer of 5-aminosalicylic acid and cystine.

  Drug delivery 20080101

• Management of cystinuric patients: an observational, retrospective, single-centre analysis.

  Urologia internationalis 20080101

• Hematological manifestations of nephropathic cystinosis.

  Acta haematologica 20080101

• Effect of disulfide-containing compounds on the Na+ transport in the frog skin.

  Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20080101

• Molecular characterization and complete genome sequence of avian paramyxovirus type 4 prototype strain duck/Hong Kong/D3/75.

  Virology journal 20080101

• Left handed beta helix models for mammalian prion fibrils.

  Prion 20080101

• Analysis on conservation of disulphide bonds and their structural features in homologous protein domain families.

  BMC structural biology 20080101

• Differential regulation of cell proliferation in neurogenic zones in mice lacking cystine transport by xCT.

  Biochemical and biophysical research communications 20071221

• beta-sheet hydrogen bonding patterns in cystine peptides.

  Organic letters 20071220

• Chemical disulfide mapping identifies an inhibitor cystine knot in the agouti signaling protein.

  FEBS letters 20071211

• Suppression by glutamate of proliferative activity through glutathione depletion mediated by the cystine/glutamate antiporter in mesenchymal C3H10T1/2 stem cells.

  Journal of cellular physiology 20071201

• A review of the role of enhanced apoptosis in the pathophysiology of cystinosis.

  Molecular genetics and metabolism 20071201

• Cystine calculi: correlation of CT-visible structure, CT number, and stone morphology with fragmentation by shock wave lithotripsy.

  Urological research 20071201

• Noninvasive differentiation of uric acid versus non-uric acid kidney stones using dual-energy CT.

  Academic radiology 20071201

• Enhancement of antigen-specific immunoglobulin G production in mice by co-administration of L-cystine and L-theanine.

  The Journal of veterinary medical science 20071201

• Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease.

  Current genomics 20071201

• Role of the asymmetry of the homodimeric b2 stator stalk in the interaction with the F1 sector of Escherichia coli ATP synthase.

  The Journal of biological chemistry 20071102

• Protein-thiol substitution or protein dethiolation by thiol/disulfide exchange reactions: the albumin model.

  Proteins 20071101

• Cystinuria in children and young adults: success of monitoring free-cystine urine levels.

  Pediatric nephrology (Berlin, Germany) 20071101

• Mechanisms of root canal sealers cytotoxicity on osteoblastic cell line MC3T3-E1.

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20071101

• Raman spectroscopy and DFT calculations of As(III) complexation with a cysteine-rich biomaterial.

  Journal of colloid and interface science 20071101

• Comparison of collision-induced dissociation and electron-induced dissociation of singly protonated aromatic amino acids, cystine and related simple peptides using a hybrid linear ion trap-FT-ICR mass spectrometer.

  Analytical and bioanalytical chemistry 20071101

• DL-Methionine is as efficacious as L-methionine, but modest L-cystine excesses are anorexigenic in sulfur amino acid-deficient purified and practical-type diets fed to chicks.

  Poultry science 20071101

• Mapping of glutathione and its precursor amino acids reveals a role for GLYT2 in glycine uptake in the lens core.

  Investigative ophthalmology & visual science 20071101

• [Massive residual stones after ESWL for staghorn cystine calculi were completely dissolved by oral administration of alkaline citrate: a case report].

  Hinyokika kiyo. Acta urologica Japonica 20071101

• A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models.

  Biochemical pharmacology 20071015

• Extracellular cysteine/cystine redox potential controls lung fibroblast proliferation and matrix expression through upregulation of transforming growth factor-beta.

  American journal of physiology. Lung cellular and molecular physiology 20071001

• 'Forbidden' disulfides: their role as redox switches.

  Current protein & peptide science 20071001

• Intrinsic fluorescence reports a global conformational change in the N-lobe of human serum transferrin following iron release.

  Biochemistry 20070918

• Control of extracellular cysteine/cystine redox state by HT-29 cells is independent of cellular glutathione.

  American journal of physiology. Regulatory, integrative and comparative physiology 20070901

• Elution behavior of diaminopimelic acid and related diamino acids using the advanced Marfey's method.

  Journal of chromatography. A 20070810

• Biogenesis of the essential Tim9-Tim10 chaperone complex of mitochondria: site-specific recognition of cysteine residues by the intermembrane space receptor Mia40.

  The Journal of biological chemistry 20070803

• Promotion of oxidative stress in kidney of rats loaded with cystine dimethyl ester.

  Pediatric nephrology (Berlin, Germany) 20070801

• Improved sequencing of oxidized cysteine and methionine containing peptides using electron transfer dissociation.

  Journal of the American Society for Mass Spectrometry 20070801

• Cystine dimethylester model of cystinosis: still reliable?

  Pediatric research 20070801

• Clinical presentation of CADASIL in an Italian patient with a rare Gly528Cys exon 10 NOTCH3 gene mutation.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20070801

• Organelle redox of CF and CFTR-corrected airway epithelia.

  Free radical biology & medicine 20070715

• Paracetamol overdose as a result of dental pain requiring medical treatment - two case reports.

  British dental journal 20070714

• Effect of cysteine and cystine addition on sensory profile and potent odorants of extruded potato snacks.

  Journal of agricultural and food chemistry 20070711

• The disulfide bond pattern of salmon egg lectin 24K from the Chinook salmon Oncorhynchus tshawytscha.

  Archives of biochemistry and biophysics 20070701

• Haemophagocytosis by myeloid precursors in lysinuric protein intolerance.

  British journal of haematology 20070701

• In vitro toxicity induced by methylmercury on sympathetic neurons is reverted by L-cysteine or glutathione.

  Neuroscience research 20070701

• Modification of Gd-DTPA cystine copolymers with PEG-1000 optimizes pharmacokinetics and tissue retention for magnetic resonance angiography.

  Magnetic resonance in medicine 20070701

• 1H, 13C and 15N resonance assignment of the oxidized form (Cys(67)-Cys (70)) of the N-terminal domain of PilB from Neisseria meningitidis.

  Biomolecular NMR assignments 20070701

• A mass spectrometric investigation of native and oxidatively inactivated chloroperoxidase.

  Chembiochem : a European journal of chemical biology 20070618

• Protect from light: photodegradation and protein biologics.

  Journal of pharmaceutical sciences 20070601

• Upregulation of cerebral cortical glutathione synthesis by ammonia in vivo and in cultured glial cells: the role of cystine uptake.

  Neurochemistry international 20070601

• Chemoprevention of smoke-induced alopecia in mice by oral administration of L-cystine and vitamin B6.

  Journal of dermatological science 20070601

• Expression and developmental regulation of the cystine/glutamate exchanger (xc-) in the rat.

  Neurochemical research 20070601

• Measurement of cystine in granulocytes using liquid chromatography-tandem mass spectrometry.

  Clinical biochemistry 20070601

• Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development.

  Journal of the American Society of Nephrology : JASN 20070601

• Monitoring of chemotherapy-induced cell death in melanoma tumors by N,N'-Didansyl-L-cystine.

  Technology in cancer research & treatment 20070601

• Isolated cystinuria (OMIM 238200) is not a separate entity but is caused by a mutation in the cystinuria gene SLC7A9.

  Clinical genetics 20070601

• Amino acid composition of two masticatory nuts (Cola acuminata and Garcinia kola) and a snack nut (Anacardium occidentale).

  International journal of food sciences and nutrition 20070601

• System xc- and glutamate transporter inhibition mediates microglial toxicity to oligodendrocytes.

  Journal of immunology (Baltimore, Md. : 1950) 20070515

• Cystine-modified biomass for Cd(II) and Pb(II) biosorption.

  Journal of hazardous materials 20070508

• Novel molecular imaging of cell death in experimental cerebral stroke.

  Brain research 20070504

• Ceftriaxone associated nephrolithiasis: a prospective study in 284 children.

  Pediatric nephrology (Berlin, Germany) 20070501

• Structure and conformation of the disulfide bond in dimeric lung surfactant peptides SP-B1-25 and SP-B8-25.

  Biochimica et biophysica acta 20070501

• A bacterial two-hybrid system based on the twin-arginine transporter pathway of E. coli.

  Protein science : a publication of the Protein Society 20070501

• Glycosides from the stem bark of Fraxinus sieboldiana.

  Journal of natural products 20070501

• Protective effect of a novel cystine C(60) derivative on hydrogen peroxide-induced apoptosis in rat pheochromocytoma PC12 cells.

  Chemico-biological interactions 20070425

• Modulation of cellular disulfide-bond formation and the ER redox environment by feedback regulation of Ero1.

  Cell 20070420

• Expression and function of cystine/glutamate transporter in neutrophils.

  Journal of leukocyte biology 20070401

• Glutamate suppresses osteoclastogenesis through the cystine/glutamate antiporter.

  The American journal of pathology 20070401

• A Ser326Cys polymorphism in the DNA repair gene hOGG1 is not associated with sporadic Alzheimer's disease.

  Neuroscience letters 20070313

• Evaluation and improvement of the properties of the novel cystine-knot microprotein McoEeTI for oral administration.

  International journal of pharmaceutics 20070306

• Linkage between the intramembrane H-bond network around aspartic acid 83 and the cytosolic environment of helix 8 in photoactivated rhodopsin.

  Journal of molecular biology 20070302

• The Uromodulin C744G mutation causes MCKD2 and FJHN in children and adults and may be due to a possible founder effect.

  Kidney international 20070301

• N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury.

  Annals of neurology 20070301

• Detailed structural analysis of amyloidogenic wild-type transthyretin using a novel purification strategy and mass spectrometry.

  Analytical chemistry 20070301

• Regional differences in cystine accumulation point to a sutural delivery pathway to the lens core.

  Investigative ophthalmology & visual science 20070301

• [Modulation of the phenotypic expression in the patient with cystinuria: influence of therapeutic intervention and diet].

  Archivos espanoles de urologia 20070301

• The lathyrus toxin, beta-N-oxalyl-L-alpha,beta-diaminopropionic acid (ODAP), and homocysteic acid sensitize CA1 pyramidal neurons to cystine and L-2-amino-6-phosphonohexanoic acid.

  Toxicology and applied pharmacology 20070215

• Identification of an intersubunit cross-link between substituted cysteine residues located in the putative ATP binding site of the P2X1 receptor.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070207

• Sulfasalazine-induced cystine starvation: potential use for prostate cancer therapy.

  The Prostate 20070201

• Ligands selective for alpha4beta2 but not alpha3beta4 or alpha7 nicotinic receptors generalise to the nicotine discriminative stimulus in the rat.

  Psychopharmacology 20070201

• Effects of long-term zinc supplementation on plasma thiol metabolites and redox status in patients with age-related macular degeneration.

  American journal of ophthalmology 20070201

• High-throughput synthesis of conopeptides: a safety-catch linker approach enabling disulfide formation in 96-well format.

  Journal of peptide science : an official publication of the European Peptide Society 20070201

• Cystine inhibits creatine kinase activity in pig retina.

  Archives of medical research 20070201

• A characteristic phenotypic retinal appearance in Norrie disease.

  Retina (Philadelphia, Pa.) 20070201

• The CARI guidelines. Kidney stones: cystine stones.

  Nephrology (Carlton, Vic.) 20070201

• Human eosinophil major basic protein 2: location of disulfide bonds and free sulfhydryl groups.

  The protein journal 20070101

• N,N-diacetyl-L-cystine improves endothelial function in atherosclerotic Watanabe heritable hyperlipidaemic rabbits.

  Basic & clinical pharmacology & toxicology 20070101

• Nephropathic cystinosis with bone marrow involvement.

  British journal of haematology 20070101

• A novel multielemental scanning thermal analysis (MESTA) method for the identification and characterization of solid substances.

  Journal of AOAC International 20070101

• Modification of proteins by cyclopentenone prostaglandins is differentially modulated by GSH in vitro.

  Annals of the New York Academy of Sciences 20070101

• Kinetics of uptake and deacetylation of N-acetylcysteine by human erythrocytes.

  The international journal of biochemistry & cell biology 20070101

• Effect of saliva, epigallocatechin gallate and hypoxia on Cu-induced oxidation and cytotoxicity.

  In vivo (Athens, Greece) 20070101

• Pathophysiology and clinical aspects of urinary lithiasis.

  Urologia internationalis 20070101

• Prevention of stone disease.

  Urologia internationalis 20070101

• Fundamental DSC investigations of alpha-keratinous materials as basis for the interpretation of specific effects of chemical, cosmetic treatments on human hair.

  Journal of cosmetic science 20070101

• Composition and clinically determined hardness of urinary tract stones.

  Scandinavian journal of urology and nephrology 20070101

• Excess dietary cystine intensifies the adverse effect of a methionine deficiency in the cat.

  Journal of animal physiology and animal nutrition 20061201

• CART (85-102)-inhibition of psychostimulant-induced hyperlocomotion: importance of cyclization.

  Peptides 20061201

• Cystine calculi: challenging group of stones.

  Postgraduate medical journal 20061201

• Inhibition of plasminogen activator inhibitor-1 binding to endocytosis receptors of the low-density-lipoprotein receptor family by a peptide isolated from a phage display library.

  The Biochemical journal 20061101

• Ion-exchange and potentiometric characterization of Al-cystine and Al-cysteine complexes.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20061101

• Cyclic insulin-regulated aminopeptidase (IRAP)/AT4 receptor ligands.

  Journal of peptide science : an official publication of the European Peptide Society 20061101

• [Modern general metaphylaxis of stone disease. New risks, new evidence, new recommendations].

  Der Urologe. Ausg. A 20061101

• Preclinical antitumor activity, pharmacokinetics and pharmacodynamics of imexon in mice.

  Anti-cancer drugs 20061101

• Simultaneous quantitation of homocysteine, cysteine and methionine in plasma and urine by liquid chromatography-tandem mass spectrometry.

  Annals of clinical biochemistry 20061101

• Cysteine, cystine or N-acetylcysteine supplementation in parenterally fed neonates.

  The Cochrane database of systematic reviews 20061018

• Kinetics and mechanisms of chlorine dioxide and chlorite oxidations of cysteine and glutathione.

  Inorganic chemistry 20061016

• Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20061011

• Multi-template approach to modeling engineered disulfide bonds.

  Proteins 20061001

• Controlled synthesis of (S,S)-2,7-diaminosuberic acid: a method for regioselective construction of dicarba analogues of multicystine-containing peptides.

  The Journal of organic chemistry 20060929

• -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia.

  World journal of gastroenterology 20060914

• High-level production of bioactive human beta-defensin-4 in Escherichia coli by soluble fusion expression.

  Applied microbiology and biotechnology 20060901

• Glutamate inhibits chondral mineralization through apoptotic cell death mediated by retrograde operation of the cystine/glutamate antiporter.

  The Journal of biological chemistry 20060825

• LDL oxidized with iron in the presence of homocysteine/cystine at acidic pH has low cytotoxicity despite high lipid peroxidation.

  Atherosclerosis 20060801

• Protective role of L-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060801

• Pharmacokinetics, biodistribution and contrast enhanced MR blood pool imaging of Gd-DTPA cystine copolymers and Gd-DTPA cystine diethyl ester copolymers in a rat model.

  Pharmaceutical research 20060801

• Cysteamine dose regimen.

  Pediatric nephrology (Berlin, Germany) 20060801

• New separation method for organic and inorganic selenium compounds based on anion exchange chromatography followed by inductively coupled plasma mass spectrometry.

  Analytical and bioanalytical chemistry 20060801

• Inhibition of creatine kinase activity by cystine in the kidney of young rats.

  Pediatric research 20060801

• Adaptational modification and ligand occupancy have opposite effects on positioning of the transmembrane signalling helix of a chemoreceptor.

  Molecular microbiology 20060801

• Disulfide bridge disruption in the alpha2 domain of the HLA class I molecule leads to low expression of the corresponding antigen.

  Human immunology 20060801

• Effects of selenocystine on lead-exposed Chinese hamster ovary (CHO) and PC-12 cells.

  Toxicology and applied pharmacology 20060715

• Cystine alters the renal and hepatic disposition of inorganic mercury and plasma thiol status.

  Toxicology and applied pharmacology 20060701

• A new class of [2Fe-2S]-cluster-containing protoporphyrin (IX) ferrochelatases.

  The Biochemical journal 20060701

• Ser351Cys mutation in the fibroblast growth factor receptor 2 gene results in severe Pfeiffer syndrome.

  Clinical dysmorphology 20060701

• Irreversible thermal denaturation of elongation factor Ts from Thermus thermophilus effect of the residual structure and intermonomer disulfide bond.

  Biochimica et biophysica acta 20060701

• nDsbD: a redox interaction hub in the Escherichia coli periplasm.

  Cellular and molecular life sciences : CMLS 20060701

• Blockade of the translocation and activation of mitogen-activated protein kinase kinase 4 (MKK4) signaling attenuates neuronal damage during later ischemia-reperfusion.

  Journal of neurochemistry 20060701

• Conformational stability of secretory leucocyte protease inhibitor: a protein with no hydrophobic core and very little secondary structure.

  Biochimica et biophysica acta 20060701

• Direct amino acid analysis method for speciation of selenoamino acids using high-performance anion-exchange chromatography coupled with integrated pulsed amperometric detection.

  Journal of chromatography. A 20060616

• Selenium speciation by high-performance anion-exchange chromatography-post-column UV irradiation coupled with atomic fluorescence spectrometry.

  Journal of chromatography. A 20060616

• Rapid synthesis of a register-specific heterotrimeric type I collagen helix encompassing the integrin alpha2beta1 binding site.

  Journal of molecular biology 20060602

• Reduced renal function and benefits of treatment in cystinuria vs other forms of nephrolithiasis.

  BJU international 20060601

• Renal crystal deposits and histopathology in patients with cystine stones.

  Kidney international 20060601

• Gd-DTPA L-cystine bisamide copolymers as novel biodegradable macromolecular contrast agents for MR blood pool imaging.

  Pharmaceutical research 20060601

• Understanding intestinal cysteamine bitartrate absorption.

  The Journal of pediatrics 20060601

• Non-covalent binding of fullerenes and biomolecules at surface-supported metallosupramolecular receptors.

  Chemical communications (Cambridge, England) 20060528

• Norcystine, a new tool for the study of the structure-activity relationship of peptides.

  Organic letters 20060525

• Role of the Cys18-Cys274 disulfide bond and of the third extracellular loop in the constitutive activation and internalization of angiotensin II type 1 receptor.

  Regulatory peptides 20060515

• Quantification of fudosteine in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry employing precolumn derivatization with 9-fluorenylmethyl chloroformate.

  Journal of mass spectrometry : JMS 20060501

• The electrochemical reaction mechanism of selenocystine on selenium-gold film modified glassy carbon electrode.

  Colloids and surfaces. B, Biointerfaces 20060501

• Design and synthesis of potent cystine-free cyclic hexapeptide agonists at the human urotensin receptor.

  Organic letters 20060427

• Hydrophobin HFBII in detail: ultrahigh-resolution structure at 0.75 A.

  Acta crystallographica. Section D, Biological crystallography 20060401

• Changing cellular location of CheZ predicted by molecular simulations.

  PLoS computational biology 20060401

• The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug delivery.

  Journal of drug targeting 20060401

• Examination of the slow unfolding of pro-nerve growth factor argues against a loop threading mechanism for nerve growth factor.

  Biochemistry 20060321

• Consequences of ERp57 deletion on oxidative folding of obligate and facultative clients of the calnexin cycle.

  The Journal of biological chemistry 20060310

• ApoSense: a novel technology for functional molecular imaging of cell death in models of acute renal tubular necrosis.

  European journal of nuclear medicine and molecular imaging 20060301

• New oxo-bridged peroxotungsten complexes containing biogenic co-ligand as potent inhibitors of alkaline phosphatase activity.

  Molecular and cellular biochemistry 20060301

• A proteomic approach to verify in vivo expression of a novel gamma-gliadin containing an extra cysteine residue.

  Proteomics 20060301

• Urinary cystine excretion and capacity in patients with cystinuria.

  Kidney international 20060301

• Effects of supplemental cystine or methionine on growth and lifespan of stroke-prone spontaneously hypertensive rats.

  The British journal of nutrition 20060301

• The cyclotides and related macrocyclic peptides as scaffolds in drug design.

  Current opinion in drug discovery & development 20060301

• S-nitrosocysteine elicits hemodynamic responses similar to those of the Bezold-Jarisch reflex via activation of stereoselective recognition sites.

  European journal of pharmacology 20060215

• Ascorbic acid reduction of microtubule protein disulfides and its relevance to protein S-nitrosylation assays.

  Biochemical and biophysical research communications 20060210

• Effect of pH on one-electron oxidation chemistry of organoselenium compounds in aqueous solutions.

  The journal of physical chemistry. A 20060209

• Adeno-associated virus-mediated gene transfer of a secreted form of TRAIL inhibits tumor growth and occurrence in an experimental tumor model.

  The journal of gene medicine 20060201

• Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif.

  The Biochemical journal 20060201

• Effect of amino acids containing sulfur on dithiolopyrrolone antibiotic productions by Saccharothrix algeriensis NRRL B-24137.

  Journal of applied microbiology 20060201

• High plasma cyst(e)ine level may indicate poor clinical outcome in patients with acute stroke: possible involvement of hydrogen sulfide.

  Journal of neuropathology and experimental neurology 20060201

• Biosynthesis of the cyclotide Kalata B1 by using protein splicing.

  Angewandte Chemie (International ed. in English) 20060130

• The central role of metal coordination in selenium antioxidant activity.

  Inorganic chemistry 20060123

• Enrichment of in vitro maturation medium for buffalo (Bubalus bubalis) oocytes with thiol compounds: effects of cystine on glutathione synthesis and embryo development.

  Theriogenology 20060120

• Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size.

  The Journal of biological chemistry 20060120

• Scanning cysteine mutagenesis analysis of Abeta-(1-40) amyloid fibrils.

  The Journal of biological chemistry 20060113

• Mechanistic implications of the structure of the mixed-disulfide intermediate of the disulfide oxidoreductase, 2-ketopropyl-coenzyme M oxidoreductase/carboxylase.

  Biochemistry 20060110

• Strict cysteamine dose regimen is required to prevent nocturnal cystine accumulation in cystinosis.

  Pediatric nephrology (Berlin, Germany) 20060101

• On the kinetics and mechanism of the reaction of cysteine and hydrogen peroxide in aqueous solution.

  Journal of pharmaceutical sciences 20060101

• Application of an exact mathematical model and the steady-state approximation to the kinetics of the reaction of cysteine and hydrogen peroxide in aqueous solution: a reply to the Ashby and Nagy commentary.

  Journal of pharmaceutical sciences 20060101

• Heterogeneous mutations in the SLC3A1 and SLC7A9 genes in Chinese patients with cystinuria.

  Kidney international 20060101

• Oleandrin-mediated oxidative stress in human melanoma cells.

  Journal of experimental therapeutics & oncology 20060101

• A robust hybrid peptide crystal formed with weak hydrogen bonds.

  Biopolymers 20060101

• The effect of engineered disulfide bonds on the stability of Drosophila melanogaster acetylcholinesterase.

  BMC biochemistry 20060101

• Xenobiotics in vitro: the influence of L-cystine, pantothenat, and miliacin on metabolic and proliferative capacity of keratinocytes.

  Cutaneous and ocular toxicology 20060101

• Ebselen attenuates oxidative stress in ischemic astrocytes depleted of glutathione. Comparison with glutathione precursors.

  Pharmacological reports : PR 20060101

• The pharmacokinetics of orally administered fudosteine in healthy Chinese volunteers.

  European journal of drug metabolism and pharmacokinetics 20060101

• [Cystinosis--an orphan disease. Pathogenesis and current treatment].

  Przeglad lekarski 20060101

• Renal lithiasis and nutrition.

  Nutrition journal 20060101

• Redefining oxidative stress.

  Antioxidants & redox signaling 20060101

• [Nuclear organization and expression of milk protein genes].

  Journal de la Societe de biologie 20060101

• Cytisine for the treatment of nicotine addiction: from a molecule to therapeutic efficacy.

  Pharmacological reports : PR 20060101

• Characterization of the redox and metal binding activity of BsSco, a protein implicated in the assembly of cytochrome c oxidase.

  Biochemistry 20051227

• A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors.

  The Journal of biological chemistry 20051216

• A novel conotoxin framework with a helix-loop-helix (Cs alpha/alpha) fold.

  Biochemistry 20051213

• The two cysteine-rich head domains of minicollagen from Hydra nematocysts differ in their cystine framework and overall fold despite an identical cysteine sequence pattern.

  Journal of molecular biology 20051202

• Biochemical characterization, stability studies and N-terminal sequence of a bi-functional inhibitor from Phaseolus aureus Roxb. (Mung bean).

  Biochimie 20051201

• Expression in Escherichia coli and disulfide bridge mapping of PSC33, an allergenic 2S albumin from peanut.

  Protein expression and purification 20051201

• Sulfur amino acids in Cushing's disease: insight in homocysteine and taurine levels in patients with active and cured disease.

  The Journal of clinical endocrinology and metabolism 20051201

• Distinct nuclear factor-kappaB/Rel proteins have opposing modulatory effects in glutamate-induced cell death in HT22 cells.

  Neurochemistry international 20051201

• Urine sediment from a Chihuahua.

  Veterinary clinical pathology 20051201

• Urological intervention in patients with cystinuria is decreased with medical compliance.

  The Journal of urology 20051201

• Crystal structure of a non-hemorrhagic fibrin(ogen)olytic metalloproteinase complexed with a novel natural tri-peptide inhibitor from venom of Agkistrodon acutus.

  Journal of structural biology 20051201

• Antioxidant supplements prevent oxidation of cysteine/cystine redox in patients with age-related macular degeneration.

  American journal of ophthalmology 20051201

• Relationship between zinc parameters and either body weight gain, protein intake or survival time in zinc-deficient rats.

  Journal of nutritional science and vitaminology 20051201

• Persistent glycoprotein misfolding activates the glucosidase II/UGT1-driven calnexin cycle to delay aggregation and loss of folding competence.

  Molecular cell 20051123

• Elevated oxidized glutathione in cystinotic proximal tubular epithelial cells.

  Biochemical and biophysical research communications 20051118

• Study of primary amines for nucleophilic cleavage of cyanylated cystinyl proteins in disulfide mass mapping methodology.

  Analytical biochemistry 20051115

• Redox imbalance in cystine/glutamate transporter-deficient mice.

  The Journal of biological chemistry 20051111

• Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5).

  Carcinogenesis 20051101

• Fatigue of kidney stones with heterogeneous microstructure subjected to shock-wave lithotripsy.

  Journal of biomedical materials research. Part B, Applied biomaterials 20051101

• Nephrolithiasis in children.

  Pediatric nephrology (Berlin, Germany) 20051101

• Prenatal diagnosis of cystinosis by quantitative measurement of cystine in chorionic villi and cultured cells.

  Prenatal diagnosis 20051101

• Confocal microscopy of the cornea in nephropathic cystinosis.

  The British journal of ophthalmology 20051101

• The role of the disulfide bond in amyloid-like fibrillogenesis in a model peptide system.

  Organic & biomolecular chemistry 20051007

• The effects of the interactions between amino acids on pyruvate kinase activity from the brain cortex of young rats.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20051001

• Protective effect of L-trans-pyrrolidine-2,4-dicarboxilic acid preload against cell death induced by oxygen/glucose deprivation in differentiated PC12 cells.

  Journal of neuroscience research 20051001

• Setaria cervi: kinetic studies of filarial glutathione synthetase by high performance liquid chromatography.

  Experimental parasitology 20051001

• Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells.

  Journal of neuroscience research 20051001

• Ascorbate is particularly effective against LDL oxidation in the presence of iron(III) and homocysteine/cystine at acidic pH.

  Biochimica et biophysica acta 20051001

• [Pharmacokinetics of fudosteine in healthy volunteers].

  Yao xue xue bao = Acta pharmaceutica Sinica 20051001

• Chiral recognition of dextran sulfate with D- and L-cystine studied by multiwavelength surface plasmon resonance.

  Carbohydrate research 20050905

• Altered status of glutathione and its metabolites in cystinotic cells.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20050901

• Carboxy-terminal truncations modify the outer pore vestibule of muscle chloride channels.

  Biophysical journal 20050901

• The effect of pressure on the crystal structure of hexagonal L-cystine.

  Journal of synchrotron radiation 20050901

• High cystine in platelets from patients with nephropathic cystinosis: a chemical, ultrastructural, and functional evaluation.

  Journal of clinical pathology 20050901

• Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance.

  Cancer research 20050815

• Inhibition of cystine uptake disrupts the growth of primary brain tumors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050803

• Cystine and glutamate transport in renal epithelial cells transfected with human system x(-) (c).

  Kidney international 20050801

• Mapping the functional domains of human transcobalamin using monoclonal antibodies.

  The FEBS journal 20050801

• Properties and significance of apoFNR as a second form of air-inactivated [4Fe-4S].FNR of Escherichia coli.

  The FEBS journal 20050801

• Effects of cystine and hydrogen peroxide on glutathione status and expression of antioxidant genes in Escherichia coli.

  Biochemistry. Biokhimiia 20050801

• Disulfide exchange in hydrogen-bonded cyclic assemblies: stereochemical self-selection by double dynamic chemistry.

  The Journal of organic chemistry 20050722

• Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050706

• Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050706

• Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor signaling.

  American journal of physiology. Gastrointestinal and liver physiology 20050701

• Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant.

  The Journal of biological chemistry 20050701

• Intravenous N-acetylcysteine does not prevent post-ERCP pancreatitis.

  Gastrointestinal endoscopy 20050701

• Crystal structure of a secreted insect ferritin reveals a symmetrical arrangement of heavy and light chains.

  Journal of molecular biology 20050610

• Intracellular proatherogenic events and cell adhesion modulated by extracellular thiol/disulfide redox state.

  Circulation 20050607

• O-raffinose crosslinked hemoglobin lacks site-specific chemistry in the central cavity: structural and functional consequences of beta93Cys modification.

  Proteins 20050601

• Transport of L-[14C]cystine and L-[14C]cysteine by subtypes of high affinity glutamate transporters over-expressed in HEK cells.

  Neurochemistry international 20050601

• Reactive sulfur species: kinetics and mechanism of the oxidation of cystine by hypochlorous acid to give N,N'-dichlorocystine.

  Chemical research in toxicology 20050601

• New binding specificities derived from Min-23, a small cystine-stabilized peptidic scaffold.

  Biochemistry 20050517

• Catalytic and direct oxidation of cysteine by octacyanomolybdate(V).

  Inorganic chemistry 20050516

• Conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter.

  The Journal of biological chemistry 20050513

• Aortic dissection and ankylosing spondylitis in hypocystinemia.

  The Journal of thoracic and cardiovascular surgery 20050501

• ERS1 encodes a functional homologue of the human lysosomal cystine transporter.

  The FEBS journal 20050501

• Misfolding of collagen X chains harboring Schmid metaphyseal chondrodysplasia mutations results in aberrant disulfide bond formation, intracellular retention, and activation of the unfolded protein response.

  The Journal of biological chemistry 20050422

• Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding.

  Brain research 20050418

• Radiolytic modification of sulfur-containing amino acid residues in model peptides: fundamental studies for protein footprinting.

  Analytical chemistry 20050415

• Cysteamine prevents and reverses the inhibition of creatine kinase activity caused by cystine in rat brain cortex.

  Neurochemistry international 20050401

• Measurement of cystine in urine by liquid chromatography-tandem mass spectrometry.

  Clinical chemistry 20050401

• Oxidative folding of conotoxins sharing an identical disulfide bridging framework.

  The FEBS journal 20050401

• Apparent fragility of African hair is unrelated to the cystine-rich protein distribution: a cytochemical electron microscopic study.

  Experimental dermatology 20050401

• Lactococcus lactis uses MscL as its principal mechanosensitive channel.

  The Journal of biological chemistry 20050311

• Oxidant-induced apoptosis in human retinal pigment epithelial cells: dependence on extracellular redox state.

  Investigative ophthalmology & visual science 20050301

• Molecular electron transfer of protein junctions characterised by conducting atomic force microscopy.

  Colloids and surfaces. B, Biointerfaces 20050225

• A pulsed potential waveform displaying enhanced detection capabilities towards sulfur-containing compounds at a gold working electrode.

  Journal of chromatography. A 20050225

• Lysosomal cystine augments apoptosis and causes the phenotype in cystinosis.

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20050218

• Peroxynitrite-mediated oxidation of the C85S/C152E mutant of dihydrofolate reductase from Escherichia coli: functional and structural effects.

  Archives of biochemistry and biophysics 20050215

• Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release.

  The Journal of biological chemistry 20050204

• Effect of the chemical form of supranutritional selenium on selenium load and selenoprotein activities in virgin, pregnant, and lactating rats.

  Journal of animal science 20050201

• Transient neonatal cystinuria.

  Kidney international 20050201

• Characterization of tiger-tail banding and hair shaft abnormalities in trichothiodystrophy.

  Journal of the American Academy of Dermatology 20050201

• [Cystinosis: an infrequent cause of distal myopathy].

  Revista de neurologia 20050201

• Mammalian isovalthine metabolism.

  Journal of animal physiology and animal nutrition 20050201

• Thimerosal neurotoxicity is associated with glutathione depletion: protection with glutathione precursors.

  Neurotoxicology 20050101

• A fusion protein system for the recombinant production of short disulfide bond rich cystine knot peptides using barnase as a purification handle.

  Protein expression and purification 20050101

• Synthesis of single- and multiple-stranded cystine-rich peptides.

  Biopolymers 20050101

• Inhibition of endotoxin- and antigen-induced airway inflammation by fudosteine, a mucoactive agent.

  Pulmonary pharmacology & therapeutics 20050101

• Ureteroscopy for pediatric urolithiasis: an evolving first-line therapy.

  Urology 20050101

• BspA (CyuC) in Lactobacillus fermentum BR11 is a highly expressed high-affinity L-cystine-binding protein.

  Current microbiology 20050101

• PEG-g-poly(GdDTPA-co-L-cystine): effect of PEG chain length on in vivo contrast enhancement in MRI.

  Biomacromolecules 20050101

• A strategy using NMR peptide structures of thromboxane A2 receptor as templates to construct ligand-recognition pocket of prostacyclin receptor.

  BMC biochemistry 20050101

• cDNA cloning and functional expression of a Ca2+-sensing receptor with truncated C-terminal tail from the Mozambique tilapia (Oreochromis mossambicus).

  The Journal of biological chemistry 20041217

• Transcriptional control of cystine/glutamate transporter gene by amino acid deprivation.

  Biochemical and biophysical research communications 20041203

• Cys-His proteases are among the wired proteins of the cell.

  Archives of biochemistry and biophysics 20041201

• Selective liberation of NO from S-nitrosocysteine with potassium thiocyanate, as monitored by an amperometric sensor.

  Archives of biochemistry and biophysics 20041201

• [Study on the interaction of cystine and polyphenol oxidase from nicotian tobaccum].

  Guang pu xue yu guang pu fen xi = Guang pu 20041201

• Transmembrane segment 3 of the Glut1 glucose transporter is an outer helix.

  The Journal of biological chemistry 20041105

• Glutathione precursors replenish decreased glutathione pool in cystinotic cell lines.

  Biochemical and biophysical research communications 20041105

• Helical CT evaluation of the chemical composition of urinary tract calculi with a discriminant analysis of CT-attenuation values and density.

  European radiology 20041101

• Mode of presentation and first line of management of non-recurrent urolithiasis in Kuwait.

  International journal of urology : official journal of the Japanese Urological Association 20041101

• Solution structure of Cu6 metallothionein from the fungus Neurospora crassa.

  European journal of biochemistry 20041101

• Shewanella profunda sp. nov., isolated from deep marine sediment of the Nankai Trough.

  International journal of systematic and evolutionary microbiology 20041101

• Exploiting thiol modifications.

  PLoS biology 20041101

• Disulfide bonds, their stereospecific environment and conservation in protein structures.

  Protein engineering, design & selection : PEDS 20041101

• In vivo homodimerisation of HTLV-1 Gag and MA gives clues to the retroviral capsid and TM envelope protein arrangement.

  Journal of molecular biology 20041029

• Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family.

  Journal of molecular biology 20041029

• C-S bond formation reaction between a phenolate and disulfide-bridged dicopper(I) complexes.

  Inorganic chemistry 20041018

• The Lathyrus excitotoxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid is a substrate of the L-cystine/L-glutamate exchanger system xc-.

  Toxicology and applied pharmacology 20041015

• Crystal structure of the cytochrome p450cam mutant that exhibits the same spectral perturbations induced by putidaredoxin binding.

  The Journal of biological chemistry 20041008

• Trans-editing of Cys-tRNAPro by Haemophilus influenzae YbaK protein.

  The Journal of biological chemistry 20041008

• Perioperative care of the patient with nephropathic cystinosis.

  Paediatric anaesthesia 20041001

• Treatment of cystinosis: simple in principle, difficult in practice.

  The Journal of pediatrics 20041001

• Long-term follow-up of well-treated nephropathic cystinosis patients.

  The Journal of pediatrics 20041001

• Interrelationship between methionine and cystine of early Peking ducklings.

  Poultry science 20041001

• Influence of N,N'-diacetyl-L-cystine on D-galactosamine/lipopolysaccharide induced immunological liver failure in mice.

  Yao xue xue bao = Acta pharmaceutica Sinica 20041001

• Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms.

  Journal of neurochemistry 20040901

• Comparison of cystine determination in mixed leukocytes vs polymorphonuclear leukocytes for diagnosis of cystinosis and monitoring of cysteamine therapy.

  Clinical chemistry 20040901

• NCD3G: a novel nine-cysteine domain in family 3 GPCRs.

  Trends in biochemical sciences 20040901

• An unconventional hypothesis of oxidation in Alzheimer's disease: intersections with excitotoxicity.

  Frontiers in bioscience : a journal and virtual library 20040901

• Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040801

• Spiral computed tomography: role in determination of chemical compositions of pure and mixed urinary stones--an in vitro study.

  Urology 20040801

• Enzymatic reactions involved in the repair of oxidized proteins.

  Experimental gerontology 20040801

• The structure of the Cys-rich terminal domain of Hydra minicollagen, which is involved in disulfide networks of the nematocyst wall.

  The Journal of biological chemistry 20040716

• Two conserved cysteine triads in human Ero1alpha cooperate for efficient disulfide bond formation in the endoplasmic reticulum.

  The Journal of biological chemistry 20040716

• Isolation and characterization at cholinergic nicotinic receptors of a neurotoxin from the venom of the Acanthophis sp. Seram death adder.

  Biochemical pharmacology 20040715

• Membrane binding modulates the quaternary structure of CTP:phosphocholine cytidylyltransferase.

  The Journal of biological chemistry 20040702

• Molecular pathogenesis of cystinosis: effect of CTNS mutations on the transport activity and subcellular localization of cystinosin.

  Human molecular genetics 20040701

• Hydrogen sulfide protects neurons from oxidative stress.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040701

• Study of selenium distribution in the protein fractions of the Brazil nut, Bertholletia excelsa.

  Journal of agricultural and food chemistry 20040630

• Cysteamine prevents and reverses the inhibition of pyruvate kinase activity caused by cystine in rat heart.

  Biochimica et biophysica acta 20040628

• Inhibition of pyruvate kinase activity by cystine in brain cortex of rats.

  Brain research 20040625

• Glial glutamate transporters limit spillover activation of presynaptic NMDA receptors and influence synaptic inhibition of Purkinje neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040623

• [Cystinosis: diagnosis through the measurement of the leukocyte cystine content by HPLC].

  Medicina clinica 20040619

• Entrapment and release of quinoline derivatives using a hydrogel of a low molecular weight gelator.

  Journal of controlled release : official journal of the Controlled Release Society 20040618

• [Cystinosis: deposition of cystine crystals in the bone marrow of a 27-year-old man].

  MMW Fortschritte der Medizin 20040610

• Prediction of the bonding states of cysteines using the support vector machines based on multiple feature vectors and cysteine state sequences.

  Proteins 20040601

• A combinatorial approach to the synthesis of cystine based organogelators.

  Journal of peptide science : an official publication of the European Peptide Society 20040601

• Structure of Ero1p, source of disulfide bonds for oxidative protein folding in the cell.

  Cell 20040528

• Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: the importance of the cyclic cystine knot.

  Biochemistry 20040525

• Determination of the disulfide bond arrangement of dengue virus NS1 protein.

  The Journal of biological chemistry 20040514

• Stimulation of Fe-S cluster insertion into apoFNR by Escherichia coli glutaredoxins 1, 2 and 3 in vitro.

  FEBS letters 20040507

• Effect of thiol antioxidant on body fat and insulin reactivity.

  Journal of molecular medicine (Berlin, Germany) 20040501

• Misfolded proinsulin accumulates in expanded pre-Golgi intermediates and endoplasmic reticulum subdomains in pancreatic beta cells of Akita mice.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040501

• Binding of phlorizin to the C-terminal loop 13 of the Na(+)/glucose cotransporter does not depend on the [560-608] disulfide bond.

  Archives of biochemistry and biophysics 20040501

• The A-superfamily of conotoxins: structural and functional divergence.

  The Journal of biological chemistry 20040423

• Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propetide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells.

  The Journal of biological chemistry 20040423

• A bacterial expression system revisited for the recombinant production of cystine-rich plant lipid transfer proteins.

  Biochemical and biophysical research communications 20040416

• Modification of cysteine residue in transthyretin and a synthetic peptide: analyses by electrospray ionization mass spectrometry.

  Biochimica et biophysica acta 20040408

• An R111C polymorphism in wild turkey cardiac troponin I accompanying the dilated cardiomyopathy-related abnormal splicing variant of cardiac troponin T with potentially compensatory effects.

  The Journal of biological chemistry 20040402

• Cellular protein kinase C isozyme regulation by exogenously delivered physiological disulfides--implications of oxidative protein kinase C regulation to cancer prevention.

  Carcinogenesis 20040401

• Vicinal disulfide bridge conformers by experimental methods and by ab initio and DFT molecular computations.

  Proteins 20040401

• Tarantulas: eight-legged pharmacists and combinatorial chemists.

  Toxicon : official journal of the International Society on Toxinology 20040401

• Stone clustering of patients with cystine urinary stone formation.

  Urology 20040401

• Amino acids and asthma: a case-control study.

  The European respiratory journal 20040401

• Prions: so many fibers, so little infectivity.

  Trends in biochemical sciences 20040401

• Identification on mouse chromosome 8 of new beta-defensin genes with regionally specific expression in the male reproductive organ.

  The Journal of biological chemistry 20040326

• [From gene to disease: cystinosis].

  Nederlands tijdschrift voor geneeskunde 20040306

• TMX, a human transmembrane oxidoreductase of the thioredoxin family: the possible role in disulfide-linked protein folding in the endoplasmic reticulum.

  Archives of biochemistry and biophysics 20040301

• Mercuric conjugates of cysteine are transported by the amino acid transporter system b(0,+): implications of molecular mimicry.

  Journal of the American Society of Nephrology : JASN 20040301

• About thiol derivatization and resolution of basic proteins in two-dimensional electrophoresis.

  Proteomics 20040301

• Assembly of MHC class I peptide complexes from the perspective of disulfide bond formation.

  Cellular and molecular life sciences : CMLS 20040301

• Reduced levels of Abeta 40 and Abeta 42 in brains of smoking controls and Alzheimer's patients.

  Neurobiology of disease 20040301

• Structure-function relationship of the extracellular calcium-sensing receptor.

  Cell calcium 20040301

• Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase.

  Biochimica et biophysica acta 20040227

• NF-kappaB-dependent induction of osteoprotegerin by Porphyromonas gingivalis in endothelial cells.

  Biochemical and biophysical research communications 20040227

• Murine Frizzled-1 behaves as an antagonist of the canonical Wnt/beta-catenin signaling.

  The Journal of biological chemistry 20040213

• Aspartate 345 of the dopamine transporter is critical for conformational changes in substrate translocation and cocaine binding.

  The Journal of biological chemistry 20040213

• Modulation of the redox state of tubulin by the glutathione/glutaredoxin reductase system.

  Biochemical and biophysical research communications 20040206

• Differentiation of substrate and non-substrate inhibitors of transport system xc(-): an obligate exchanger of L-glutamate and L-cystine.

  Neuropharmacology 20040201

• Promotion of corneal allograft survival by the induction of oxidative macrophages.

  Investigative ophthalmology & visual science 20040201

• Chemical modification of hamster arylamine N-acetyltransferase 2 with isozyme-selective and nonselective N-arylbromoacetamido reagents.

  The protein journal 20040201

• Positions of disulfide bonds and N-glycosylation site in juvenile hormone binding protein.

  Archives of biochemistry and biophysics 20040115

• L-cystine inhibits aspartate-beta-semialdehyde dehydrogenase by covalently binding to the essential 135Cys of the enzyme.

  Biochimica et biophysica acta 20040114

• Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists.

  Molecular endocrinology (Baltimore, Md.) 20040101

• Anaphylactoid reactions to intravenous N-acetylcysteine: a prospective case controlled study.

  Accident and emergency nursing 20040101

• Prevention of radiocontrast nephropathy with N-acetylcysteine in patients with chronic kidney disease: a meta-analysis of randomized, controlled trials.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20040101

• [Conversion of L-cystine and L-cysteine to taurin by the enzyme systems of liver cells].

  Prikladnaia biokhimiia i mikrobiologiia 20040101

• 'Signature sets', minimal fragment sets for identifying protein disulfide structures with cyanylation-based mass mapping methodology.

  Journal of proteome research 20040101

• PEG-g-poly(GdDTPA-co-L-cystine): a biodegradable macromolecular blood pool contrast agent for MR imaging.

  Bioconjugate chemistry 20040101

• Determination of free and total cyst(e)ine in plasma of dogs and cats.

  Veterinary clinical pathology 20040101

• Nondestructive analysis of urinary calculi using micro computed tomography.

  BMC urology 20040101

• Development of primers specific for LMW-GS genes located on chromosome 1D and molecular characterization of a gene from Glu-D3 complex locus in bread wheat.

  Hereditas 20040101

• Tracing the structure-function relationship of neuroglobin and cytoglobin using resonance Raman and electron paramagnetic resonance spectroscopy.

  IUBMB life 20040101

• [Glutathione: its biosynthesis, induction agents and concentrations in selected diseases].

  Medycyna pracy 20040101

• Role of disulfide bonds in the structure and activity of human insulin.

  Molecules and cells 20031231

• Solution structure of Alo-3: a new knottin-type antifungal peptide from the insect Acrocinus longimanus.

  Biochemistry 20031216

• Induction of the mitochondrial permeability transition by selenium compounds mediated by oxidation of the protein thiol groups and generation of the superoxide.

  Biochemical pharmacology 20031215

• Homocysteine potentiates calcification of cultured rat aortic smooth muscle cells.

  Life sciences 20031212

• Glutamine and KGF each regulate extracellular thiol/disulfide redox and enhance proliferation in Caco-2 cells.

  American journal of physiology. Regulatory, integrative and comparative physiology 20031201

• Urinary excretion of total cystine and the dibasic amino acids arginine, lysine and ornithine in relation to genetic findings in patients with cystinuria treated with sulfhydryl compounds.

  Urological research 20031201

• Redox regulation of PI3K/Akt and p53 in bovine aortic endothelial cells exposed to hydrogen peroxide.

  Antioxidants & redox signaling 20031201

• Evaluation of synchronous twin pulse technique for shock wave lithotripsy: determination of optimal parameters for in vitro stone fragmentation.

  The Journal of urology 20031201

• Inhibition mechanism of S-adenosylmethionine-induced movement deficits by prenylcysteine analogs.

  Pharmacology, biochemistry, and behavior 20031201

• Studies of urinary cystine precipitation in vitro: ontogeny of cystine nephrolithiasis and identification of meso-2,3-dimercaptosuccinic acid as a potential therapy for cystinuria.

  Molecular genetics and metabolism 20031201

• N-acetylcysteine does not prevent bronchopulmonary dysplasia in immature infants: a randomized controlled trial.

  The Journal of pediatrics 20031201

• Comparison of the performance of selenite cystine and mannitol selenite enrichment broths in the isolation of Salmonella spp. from faeces.

  Communicable disease and public health 20031201

• Spatial and dynamic interactions between phospholamban and the canine cardiac Ca2+ pump revealed with use of heterobifunctional cross-linking agents.

  The Journal of biological chemistry 20031128

• Nonnative interactions between cysteines direct productive assembly of P22 tailspike protein.

  Biophysical journal 20031101

• Evidence for cystine clustering in thermophilic proteomes.

  Trends in genetics : TIG 20031101

• Epigenetic silencing of the HIC-1 gene in human medulloblastomas.

  Journal of neuropathology and experimental neurology 20031101

• Bidirectional modulation of cystine/glutamate exchanger activity in cultured cortical astrocytes.

  Annals of the New York Academy of Sciences 20031101

• Arylamine N-acetyltransferases: covalent modification and inactivation of hamster NAT1 by bromoacetamido derivatives of aniline and 2-aminofluorene.

  Journal of protein chemistry 20031101

• Interacting helical surfaces of the transmembrane segments of subunits a and c' of the yeast V-ATPase defined by disulfide-mediated cross-linking.

  The Journal of biological chemistry 20031024

• Cystine uptake prevents production of hydrogen peroxide by Lactobacillus fermentum BR11.

  FEMS microbiology letters 20031010

• A Schistosoma japonicum very low-density lipoprotein-binding protein.

  The international journal of biochemistry & cell biology 20031001

• Astrocyte-mediated methylmercury neurotoxicity.

  Biological trace element research 20031001

• Characterization of ATPase activity of a hepatitis C virus NS3 helicase domain, and analysis involving mercuric reagents.

  Journal of biochemistry 20031001

• Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA.

  The Journal of biological chemistry 20030905

• The calpain domain of the maize DEK1 protein contains the conserved catalytic triad and functions as a cysteine proteinase.

  The Journal of biological chemistry 20030905

• Expression and regulation of L-cystine transporter, system xc-, in the newly developed rat retinal Müller cell line (TR-MUL).

  Glia 20030901

• Slc7a9-deficient mice develop cystinuria non-I and cystine urolithiasis.

  Human molecular genetics 20030901

• A mouse model for cystinuria type I.

  Human molecular genetics 20030901

• An engineered interdomain disulfide bond stabilizes human blood coagulation factor VIIIa.

  Journal of thrombosis and haemostasis : JTH 20030901

• Automated data interpretation based on the concept of 'negative signature mass' for mass-mapping disulfide structures of cystinyl proteins.

  Journal of the American Society for Mass Spectrometry 20030901

• Evolutionary origin of inhibitor cystine knot peptides.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030901

• Disruption of the Cys5-Cys7 disulfide bridge in the platelet glycoprotein Ibbeta prevents the normal maturation and surface exposure of GPIb-IX complexes.

  Thrombosis and haemostasis 20030901

• Methionine and cystine requirements of slow- and fast-feathering male broilers from zero to three weeks of age.

  Poultry science 20030901

• Methionine and cystine requirements of slow- and fast-feathering broiler males from three to six weeks of age.

  Poultry science 20030901

• [Inferior polar nephrectomy for multi-recurrent inferior caliceal cystine lithiasis].

  Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie 20030901

• Structure-function analysis of recombinant substrate protein 22 kDa (SP-22). A mitochondrial 2-CYS peroxiredoxin organized as a decameric toroid.

  The Journal of biological chemistry 20030829

• Synthesis of N-acetyl-S-(3-coumarinyl)-cysteine methyl ester and HPLC analysis of urinary coumarin metabolites.

  Toxicology 20030828

• Nanosecond dynamics of the mouse acetylcholinesterase cys69-cys96 omega loop.

  The Journal of biological chemistry 20030815

• Crystal structure of a proteolytically generated functional monoferric C-lobe of bovine lactoferrin at 1.9A resolution.

  Journal of molecular biology 20030808

• The role of cystine knots in collagen folding and stability, part I. Conformational properties of (Pro-Hyp-Gly)5 and (Pro-(4S)-FPro-Gly)5 model trimers with an artificial cystine knot.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20030804

• The role of cystine knots in collagen folding and stability, part II. Conformational properties of (Pro-Hyp-Gly)n model trimers with N- and C-terminal collagen type III cystine knots.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20030804

• Using analytical ultracentrifugation to study compositional variation in vertebrate genomes.

  European biophysics journal : EBJ 20030801

• Effects on in vitro embryo development and intracellular glutathione content of the presence of thiol compounds during maturation of prepubertal goat oocytes.

  Molecular reproduction and development 20030801

• Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030702

• Cystine crystal volume determination: a useful tool in the management of cystinuric patients.

  Urological research 20030701

• Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse.

  Nature neuroscience 20030701

• Mechanisms by which cysteine can inhibit or promote the oxidation of low density lipoprotein by copper.

  Atherosclerosis 20030701

• Refolding mechanism of ovalbumin: investigation by using a starting urea-denatured disulfide isomer with mispaired CYS367-CYS382.

  The Journal of biological chemistry 20030627

• Theoretical study of nucleophilic substitution at the disulfide bridge of cyclo-l-cystine.

  The Journal of organic chemistry 20030613

• Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT.

  Biochemical and biophysical research communications 20030606

• Rhodium-catalyzed disulfide exchange reaction.

  Journal of the American Chemical Society 20030604

• Screening of human primary melanocytes of defined melanocortin-1 receptor genotype: pigmentation marker, ultrastructural and UV-survival studies.

  Pigment cell research 20030601

• Association of the 5-HT2c gene with susceptibility and minimum body mass index in anorexia nervosa.

  Neuroreport 20030506

• EPR spectroscopy shows a microtubule-dependent conformational change in the kinesin switch 1 domain.

  Biophysical journal 20030501

• Nephrolithiasis in Cushing's disease: prevalence, etiopathogenesis, and modification after disease cure.

  The Journal of clinical endocrinology and metabolism 20030501

• Homocysteine strongly enhances metal-catalyzed LDL oxidation in the presence of cystine and cysteine.

  Atherosclerosis 20030501

• Inter-domain redox communication in flavoenzymes of the quiescin/sulfhydryl oxidase family: role of a thioredoxin domain in disulfide bond formation.

  Biochemistry 20030422

• N-acetylcysteine infusion alters blood redox status but not time to fatigue during intense exercise in humans.

  Journal of applied physiology (Bethesda, Md. : 1985) 20030401

• Chemical modification of the mitochondrial ornithine/citrulline carrier by SH reagents: effects on the transport activity and transition from carrier to pore-like function.

  Biochimica et biophysica acta 20030401

• Stimulation of prothrombinase activity by the nonapeptide Thr-Trp-Ala-Arg-Asn-Ser-Tyr-Asn-Val, a segment of a plant thionin.

  Peptides 20030401

• Role of cystine transport in intracellular glutathione level and cisplatin resistance in human ovarian cancer cell lines.

  British journal of cancer 20030324

• A new member of plant CS-lyases. A cystine lyase from Arabidopsis thaliana.

  The Journal of biological chemistry 20030321

• Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking.

  The Journal of biological chemistry 20030314

• Heterotypic interactions between transferrin receptor and transferrin receptor 2.

  Blood 20030301

• Regulation of L-cystine transport and intracellular GSH level by a nitric oxide donor in primary cultured rabbit conjunctival epithelial cell layers.

  Investigative ophthalmology & visual science 20030301

• Utilization of different soy products as affected by age in chicks.

  Poultry science 20030301

• Effects of adding some dietary fibers to a cystine diet on the activities of liver antioxidant enzymes and serum enzymes in rats.

  Bioscience, biotechnology, and biochemistry 20030301

• Retinyl esters are the substrate for isomerohydrolase.

  Biochemistry 20030225

• Molecular dynamics simulations of the unfolding mechanism of the catalytic domain from Aspergillus awamori var. X100 glucoamylase.

  Journal of biomolecular structure & dynamics 20030201

• Structure and polymorphism of the principal neutralization site of Thailand HIV-1 isolate.

  Journal of biomolecular structure & dynamics 20030201

• PKC isozyme S-cysteinylation by cystine stimulates the pro-apoptotic isozyme PKC delta and inactivates the oncogenic isozyme PKC epsilon.

  Carcinogenesis 20030201

• Capillary isotachophoresis of cystine in urine with on-line isotachophoresis sample pretreatment.

  Die Pharmazie 20030201

• [Pathophysiology, diagnosis and conservative therapy of non-calcium kidney calculi].

  Therapeutische Umschau. Revue therapeutique 20030201

• Functional cooperation of epithelial heteromeric amino acid transporters expressed in madin-darby canine kidney cells.

  The Journal of biological chemistry 20030110

• Snapshots of the cystine lyase C-DES during catalysis. Studies in solution and in the crystalline state.

  The Journal of biological chemistry 20030103

• Durability of the medical management of cystinuria.

  The Journal of urology 20030101

• Quantitation and location of disulfide bonds in proteins.

  Methods in molecular biology (Clifton, N.J.) 20030101

• Vitamin C inhibits diethylmaleate-induced L-cystine transport in human vascular smooth muscle cells.

  Free radical biology & medicine 20030101

• Nutritional evaluation of dried tomato seeds.

  Poultry science 20030101

• [Cystinosis: from cystine crystals to the cystinosin].

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20030101

• Structural and functional properties of IL-4delta2, an alternative splice variant of human IL-4.

  Journal of proteome research 20030101

• The antiatherogenic effect of DiNAC: experimental findings supporting immunomodulation as a new treatment for atherosclerosis related diseases.

  Cardiovascular drug reviews 20030101

• Role of gamma-glutamyltransferase in the homeostasis of glutathione during oxidative and nitrosative stress.

  BioFactors (Oxford, England) 20030101

• Subcycling PCR for long-distance amplifications of regions with high and low guanine-cystine content: amplification of the intron 22 inversion of the FVIII gene.

  Methods in molecular biology (Clifton, N.J.) 20030101

• Single amino acids in the carboxyl terminal domain of aquaporin-1 contribute to cGMP-dependent ion channel activation.

  BMC physiology 20030101

• Understanding base-assisted desulfurization using a variety of disulfide-bridged peptides.

  Biopolymers 20030101

• Suppression of cystine uptake by sulfasalazine inhibits proliferation of human mammary carcinoma cells.

  Anticancer research 20030101

• Orientation and motion of myosin light chain and troponin in reconstituted muscle fibers as detected by ESR with a new bifunctional spin label.

  Advances in experimental medicine and biology 20030101

• A huge bladder cystine stone.

  International urology and nephrology 20030101

• Correlations of cationic charges with salt sensitivity and microbial specificity of cystine-stabilized beta -strand antimicrobial peptides.

  The Journal of biological chemistry 20021227

• Structural basis of BMP signalling inhibition by the cystine knot protein Noggin.

  Nature 20021212

• Polyethylene glycol conjugation at Cys232 prolongs the half-life of alpha1 proteinase inhibitor.

  American journal of respiratory cell and molecular biology 20021201

• Extracellular thiol/disulfide redox state affects proliferation rate in a human colon carcinoma (Caco2) cell line.

  Free radical biology & medicine 20021201

• Medical evaluation of nephrolithiasis.

  Endocrinology and metabolism clinics of North America 20021201

• S-nitrosocysteine and cystine from reaction of cysteine with nitrous acid. A kinetic investigation.

  The Journal of organic chemistry 20021129

• Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression.

  The Journal of biological chemistry 20021122

• Purification, characterization and identification of cysteine desulfhydrase of Corynebacterium glutamicum, and its relationship to cysteine production.

  FEMS microbiology letters 20021119

• Renaturation of human proinsulin--a study on refolding and conversion to insulin.

  Analytical biochemistry 20021115

• Production of intracellular 35S-glutathione by rat and human hepatocytes for the quantification of xenobiotic reactive intermediates.

  Chemico-biological interactions 20021110

• Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif.

  The Journal of biological chemistry 20021108

• The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor.

  The Journal of biological chemistry 20021108

• Toward synthetic analogues of linked redox and catalytic multimetal sites in proteins: a model of the histidine-cysteine bridged dicopper array.

  Inorganic chemistry 20021104

• Roles of disulfide bridges in scorpion toxin BmK M1 analyzed by mutagenesis.

  The journal of peptide research : official journal of the American Peptide Society 20021101

• Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine.

  The Journal of pharmacology and experimental therapeutics 20021101

• C-terminal cysteine residues determine the IgE binding of Aspergillus fumigatus allergen Asp f 2.

  Journal of immunology (Baltimore, Md. : 1950) 20021101

• Cystinosis: from gene to disease.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20021101

• Preventing kidney stones: calcium restriction not warranted.

  Cleveland Clinic journal of medicine 20021101

• Mouse methionine sulfoxide reductase B: effect of selenocysteine incorporation on its activity and expression of the seleno-containing enzyme in bacterial and mammalian cells.

  Biochemical and biophysical research communications 20021004

• Skin colour and skin cancer - MC1R, the genetic link.

  Melanoma research 20021001

• Characterization of selenium species in Brazil nuts by HPLC-ICP-MS and ES-MS.

  Journal of agricultural and food chemistry 20020925

• Role of disulfide bonds in folding and activity of leiurotoxin I: just two disulfides suffice.

  Biochemistry 20020924

• The [Lys(-2)-Arg(-1)-des(17-21)]-endothelin-1 peptide retains the specific Arg(-1)-Asp8 salt bridge but reveals discrepancies between NMR data and molecular dynamics simulations.

  Biochemistry 20020917

• The light subunit of system b(o,+) is fully functional in the absence of the heavy subunit.

  The EMBO journal 20020916

• Disruption of the long-range GPIIIa Cys(5)-Cys(435) disulfide bond results in the production of constitutively active GPIIb-IIIa (alpha(IIb)beta(3)) integrin complexes.

  Blood 20020915

• Discrimination between mono- and trimethylated cap structures by two isoforms of Caenorhabditis elegans eIF4E.

  The EMBO journal 20020902

• rBAT-b(0,+)AT heterodimer is the main apical reabsorption system for cystine in the kidney.

  American journal of physiology. Renal physiology 20020901

• Potential involvement of copper and thiol-disulphide interchange in prion proteins' conformational conversion.

  Medical hypotheses 20020901

• Crystalline histiocytosis in hereditary cysinosis.

  Archives of pathology & laboratory medicine 20020901

• Roles of endogenous glutathione levels on 6-hydroxydopamine-induced apoptotic neuronal cell death in human neuroblastoma SK-N-SH cells.

  Neuropharmacology 20020901

• [Optimal conditions for determination of L-cystine using capillary isotachophoresis].

  Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20020901

• Intracellular redox regulation by a cystine derivative suppresses UV-induced NF-kappa B activation.

  FEBS letters 20020828

• Complete structure of an increasing capillary permeability protein (ICPP) purified from Vipera lebetina venom. ICPP is angiogenic via vascular endothelial growth factor receptor signalling.

  The Journal of biological chemistry 20020816

• Simple classification of renal calculi closely related to their micromorphology and etiology.

  Clinica chimica acta; international journal of clinical chemistry 20020801

• Inhibition of Na(+)-dependent transporters in cystine-loaded human renal cells: electrophysiological studies on the Fanconi syndrome of cystinosis.

  Journal of the American Society of Nephrology : JASN 20020801

• Cellular uptake of antisense oligonucleotides after complexing or conjugation with cell-penetrating model peptides.

  European journal of biochemistry 20020801

• Enzymatic properties of a new peptide deformylase from pathogenic bacterium Leptospira interrogans.

  Biochemical and biophysical research communications 20020726

• Solid-phase extraction for the simultaneous preconcentration of organic (selenocystine) and inorganic [Se(IV), Se(VI)] selenium in natural waters.

  Journal of chromatography. A 20020719

• Cystinosis.

  The New England journal of medicine 20020711

• The impact of cystinuria on renal function.

  The Journal of urology 20020701

• Apical heterodimeric cystine and cationic amino acid transporter expressed in MDCK cells.

  American journal of physiology. Renal physiology 20020701

• Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment.

  The Journal of pharmacology and experimental therapeutics 20020701

• Cysteine-mediated electron transfer in syntrophic acetate oxidation by cocultures of Geobacter sulfurreducens and Wolinella succinogenes.

  Archives of microbiology 20020701

• Cerebral cystine uptake: a tale of two transporters.

  Trends in pharmacological sciences 20020701

• Cerebral vasculature is the major target of oxidative protein alterations in bacterial meningitis.

  Journal of neuropathology and experimental neurology 20020701

• [Electrochemical reduction of pentaerythrityltetranitrate (PETN) and metabolites].

  Die Pharmazie 20020701

• Beare-Stevenson cutis gyrata syndrome with Chiari malformation.

  Acta neurochirurgica 20020701

• Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity.

  Biochemistry 20020618

• Analysis of the roles of amino acid residues in the flavoprotein tryptophan 2-monooxygenase modified by 2-oxo-3-pentynoate: characterization of His338, Cys339, and Cys511 mutant enzymes.

  Archives of biochemistry and biophysics 20020601

• Cystine transport activity of heterozygous rBAT mutants expressed in Xenopus oocytes.

  Nephron 20020601

• Specificity of resistance to oxidative stress.

  Journal of neurochemistry 20020601

• Expression of a streptococcal glucosyltransferase as a fusion to a solute-binding protein in Lactobacillus fermentum BR11.

  FEMS microbiology letters 20020521

• Role of individual disulfide bonds in hen lysozyme early folding steps.

  Protein science : a publication of the Protein Society 20020501

• Immunomodulation with DiNAC-- a new approach to the treatment of atherosclerosis?

  Expert opinion on investigational drugs 20020501

• Plasma cystine concentration and redox state in aging and physical exercise.

  Mechanisms of ageing and development 20020501

• Ru(II)-catalyzed cascade reactions in stereocontrolled construction of rigid as-indacene-bridged bis(alpha-amino acid) derivatives.

  The Journal of organic chemistry 20020419

• Exogenous cysteine and cystine promote cell proliferation in CaCo-2 cells.

  Cell proliferation 20020401

• gamma-Glutamyl transpeptidase and glutathione biosynthesis in non-tumorigenic and tumorigenic rat liver oval cell lines.

  Carcinogenesis 20020401

• Solution structures of the cis- and trans-Pro30 isomers of a novel 38-residue toxin from the venom of Hadronyche Infensa sp. that contains a cystine-knot motif within its four disulfide bonds.

  Biochemistry 20020312

• The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier.

  The EMBO journal 20020301

• Induction of xCT gene expression and L-cystine transport activity by diethyl maleate at the inner blood-retinal barrier.

  Investigative ophthalmology & visual science 20020301

• Promoting effect of beta-mercaptoethanol on in vitro development under oxidative stress and cystine uptake of bovine embryos.

  Biology of reproduction 20020301

• Facile formation of chiral calixarene analogs incorporating cystine peptide into the macrocyclic ring.

  Chemical & pharmaceutical bulletin 20020301

• Increased rate of glutathione synthesis from cystine in drug-resistant MCF-7 cells.

  Biochemical pharmacology 20020301

• Molecular dynamics simulations as a tool for improving protein stability.

  Protein engineering 20020301

• Antibacterial activities and conformations of synthetic alpha-defensin HNP-1 and analogs with one, two and three disulfide bridges.

  The journal of peptide research : official journal of the American Peptide Society 20020301

• Solution structure and dynamics of melanoma inhibitory activity protein.

  Journal of biomolecular NMR 20020301

• Hyperhomocyst(e)inemia induces accelerated transplant vascular sclerosis in syngeneic and allogeneic rat cardiac transplants.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20020301

• Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules.

  The Journal of biological chemistry 20020215

• Predicting the disulfide bonding state of cysteines using protein descriptors.

  Proteins 20020215

• Structural requirements for palmitoylation of surfactant protein C precursor.

  The Biochemical journal 20020201

• Identification of structural motifs and amino acids within the structure of human heparan sulfate 3-O-sulfotransferase that mediate enzymatic function.

  Biochemical and biophysical research communications 20020201

• Analysis of cystine in human blood for monitoring of cases of burns.

  Journal of pharmaceutical and biomedical analysis 20020201

• Structure motif discovery and mining the PDB.

  Bioinformatics (Oxford, England) 20020201

• The solution structure of gomesin, an antimicrobial cysteine-rich peptide from the spider.

  European journal of biochemistry 20020201

• Stabilization of a (betaalpha)8-barrel protein by an engineered disulfide bridge.

  European journal of biochemistry 20020201

• Amino acid concentrations in the blood of the jugular vein and peripheral artery after traumatic brain injury: decreased release of glutamate into the jugular vein in the early phase.

  Journal of neurotrauma 20020201

• Evaluation of circulating levels and renal clearance of natural amino acids in patients with Cushing's disease.

  Journal of endocrinological investigation 20020201

• Functional implications of post-translational modifications of phospholipases D1 and D2.

  Biochimica et biophysica acta 20020130

• New monomeric cobalt(II) and zinc(II) complexes of a mixed N,S(alkylthiolate) ligand: model complexes of (His)(His)(Cys) metalloprotein active sites.

  Inorganic chemistry 20020128

• Redox regulation of cytosolic glycerol-3-phosphate dehydrogenase: Cys(102) is the target of the redox control and essential for the catalytic activity.

  Biochimica et biophysica acta 20020115

• Cystine: a promoter of the growth and aggregation of calcium oxalate crystals in normal undiluted human urine.

  The Journal of urology 20020101

• Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge.

  Annals of neurology 20020101

• Male fertility is compatible with an Arg(840)Cys substitution in the AR in a large Chinese family affected with divergent phenotypes of AR insensitivity syndrome.

  The Journal of clinical endocrinology and metabolism 20020101

• The amino acid requirements of Corynebacterium diphtheriae PW 8 substrain CN 2000.

  Journal of applied microbiology 20020101

• Association of changes in the pattern of urinary calculi in Taiwanese with diet habit change between 1956 and 1999.

  Journal of the Formosan Medical Association = Taiwan yi zhi 20020101

• Tetraethylammonium block of water flux in Aquaporin-1 channels expressed in kidney thin limbs of Henle's loop and a kidney-derived cell line.

  BMC physiology 20020101

• A degradation study of a series of chloromethyl and diazomethyl ketone anti-leukemic agents.

  Drug development and industrial pharmacy 20020101

• Mitogen activated protein kinase activation and oxidant signaling in astrocytoma cells.

  Journal of neuro-oncology 20020101

• A switch in disulfide linkage during minicollagen assembly in hydra nematocysts or how to assemble a 150-bar-resistant structure.

  Journal of structural biology 20020101

• Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine administration.

  Amino acids 20020101

• Nephropathic cystinosis associated with cardiomyopathy: a 27-year clinical follow-up.

  BMC nephrology 20020101

• Cathepsin B stability, but not activity, is affected in cysteine:cystine redox buffers.

  Biological chemistry 20020101

• Dissociations of disulfide-linked gaseous polypeptide/protein anions: ion chemistry with implications for protein identification and characterization.

  Journal of proteome research 20020101

• Extracorporeal shock wave lithotripsy for cystine urolithiasis in children: outcome and complications.

  International urology and nephrology 20020101

• Role of glutamate transporters in the regulation of glutathione levels in human macrophages.

  American journal of physiology. Cell physiology 20011201

• Cargo delivery kinetics of cell-penetrating peptides.

  Biochimica et biophysica acta 20011201

• A normal rate of cellular cholesterol removal can be mediated by plasma from a patient with familial lecithin-cholesterol acyltransferase (LCAT) deficiency.

  Clinica chimica acta; international journal of clinical chemistry 20011201

• Determination of pyrophosphate in renal calculi and urine by means of an enzymatic method.

  Clinica chimica acta; international journal of clinical chemistry 20011201

• Identification and characterization of uptake systems for cystine and cysteine in cultured astrocytes and neurons: evidence for methylmercury-targeted disruption of astrocyte transport.

  Journal of neuroscience research 20011201

• Gamma-glutamyl transpeptidase and glutathione biosynthesis in non-tumorigenic and tumorigenic rat liver oval cell lines.

  Carcinogenesis 20011201

• Defect of heparin binding in plasma and recombinant von Willebrand factor with type 2 von Willebrand disease mutations.

  Thrombosis and haemostasis 20011201

• Transport measurements across Caco-2 monolayers of different organic and inorganic selenium: influence of sulfur compounds.

  Biological trace element research 20011201

• Sequential comparison of peptides containing half-cystine residues from ovalbumins of six avian species.

  Bioscience, biotechnology, and biochemistry 20011201

• Type 1 von Willebrand disease mutation Cys1149Arg causes intracellular retention and degradation of heterodimers: a possible general mechanism for dominant mutations of oligomeric proteins.

  Blood 20011115

• Cystinosin, the protein defective in cystinosis, is a H(+)-driven lysosomal cystine transporter.

  The EMBO journal 20011101

• Glutamate induces oxidative stress not mediated by glutamate receptors or cystine transporters: protective effect of melatonin and other antioxidants.

  Journal of pineal research 20011101

• Molecular mechanisms of cystine transport.

  Biochemical Society transactions 20011101

• [Development of selective antagonists against an HIV second receptor].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20011101

• [Cystinuria and cystine kidney lithiasis. Diagnosis and therapeutic approach].

  Archivos espanoles de urologia 20011101

• Thiol-disulfide exchange between nuclear-encoded and chloroplast-encoded subunits of pea acetyl-CoA carboxylase.

  The Journal of biological chemistry 20011026

• Probing conformational changes in the I-like domain and the cysteine-rich repeat of human beta 3 integrins following disulfide bond disruption by cysteine mutations: identification of cysteine 598 involved in alphaIIbbeta3 activation.

  The Journal of biological chemistry 20011019

• Demonstration of a cystine unit as a promising turn scaffold for the design of a parallel U-shaped two-helix bundle motif: crystal structure of the homodimer Cys(Aib(n))(2) (n = 3, 4).

  Biopolymers 20011015

• N,N'-diacetyl-L-cystine (DiNAC), the disulphide dimer of N-acetylcysteine, inhibits atherosclerosis in WHHL rabbits: evidence for immunomodulatory agents as a new approach to prevent atherosclerosis.

  The Journal of pharmacology and experimental therapeutics 20011001

• Oxidative glutamate toxicity can be a component of the excitotoxicity cascade.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20011001

• IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding.

  The EMBO journal 20011001

• N-acetylcysteine increases cerebral perfusion pressure in pigs with fulminant hepatic failure.

  Critical care medicine 20011001

• Ocular findings among patients with late-diagnosed or poorly controlled homocystinuria compared with a screened, well-controlled population.

  Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 20011001

• Mucus fishing syndrome: case report and new treatment option.

  Optometry (St. Louis, Mo.) 20011001

• Activation of carrier-mediated transport of L-cystine at the blood-brain and blood-retinal barriers in vivo.

  Microvascular research 20010901

• The molecular basis of Dutch infantile nephropathic cystinosis.

  Nephron 20010901

• CSTX-9, a toxic peptide from the spider Cupiennius salei: amino acid sequence, disulphide bridge pattern and comparison with other spider toxins containing the cystine knot structure.

  Cellular and molecular life sciences : CMLS 20010901

• Structural analysis of free and enzyme-bound amaranth alpha-amylase inhibitor: classification within the knottin fold superfamily and analysis of its functional flexibility.

  Protein engineering 20010901

• Kinetics in the pre-steady state of the formation of cystines in ribonucleoside diphosphate reductase: evidence for an asymmetric complex.

  Biochemistry 20010814

• Solution structure of the satiety factor, CART, reveals new functionality of a well-known fold.

  Biochemistry 20010807

• Location and mechanism of alpha 2,6-sialyltransferase dimer formation. Role of cysteine residues in enzyme dimerization, localization, activity, and processing.

  The Journal of biological chemistry 20010803

• Urinary sulfur compounds in Down syndrome.

  Clinical chemistry 20010801

• Hounsfield unit density in the determination of urinary stone composition.

  Urology 20010801

• The intellectual abilities of early-treated individuals with pyridoxine-nonresponsive homocystinuria due to cystathionine beta-synthase deficiency.

  Journal of inherited metabolic disease 20010801

• Metabolism of S-nitrosoglutathione by endothelial cells.

  American journal of physiology. Heart and circulatory physiology 20010701

• Role of the cystine-knot motif at the C-terminus of rat mucin protein Muc2 in dimer formation and secretion.

  The Biochemical journal 20010701

• Medical and surgical therapy of the cystine stone patient.

  Current opinion in urology 20010701

• Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia.

  Journal of chemical neuroanatomy 20010701

• Determination of amino acids by ion-exchange chromatography on filter paper spotted blood samples stored at different temperatures and for different periods: comparison with capillary and venous blood.

  Clinical biochemistry 20010701

• Monitoring of the subtraction process in solid-phase representational difference analysis: characterization of a candidate drug.

  Gene 20010627

• Self-assembling, cystine-derived, fused nanotubes based on spirane architecture: design, synthesis, and crystal structure of cystinospiranes.

  Journal of the American Chemical Society 20010620

• Partial restoration of lutropin activity by an intersubunit disulfide bond: implications for structure/function studies.

  Experimental biology and medicine (Maywood, N.J.) 20010601

• Estimation of the total sulfur amino acid requirement and the effect of betaine in diets deficient in total sulfur amino acids for the weanling pig.

  Journal of animal science 20010601

• Effect of fudosteine, a new cysteine derivative, on mucociliary transport.

  The Journal of pharmacy and pharmacology 20010601

• Synthesis of diaminosuberic acid derivatives via ring-closing alkyne metathesis.

  The Journal of organic chemistry 20010518

• Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules.

  Molecular endocrinology (Baltimore, Md.) 20010501

• The metabolism of sulphur in relation to the biochemistry of cystine and cysteine: its fundamental importance in biology. A cyclic interchange between their mono- and di-sulphides is the unique reaction creating life and intelligence.

  Medical hypotheses 20010501

• A new strategy for the synthesis of cyclopeptides containing diaminoglutaric acid.

  Journal of peptide science : an official publication of the European Peptide Society 20010501

• xCt cystine transporter expression in HEK293 cells: pharmacology and localization.

  Biochemical and biophysical research communications 20010420

• Functional contributions of noncysteine residues within the cystine knots of human chorionic gonadotropin subunits.

  The Journal of biological chemistry 20010406

• Cysteinylation of MHC class II ligands: peptide endocytosis and reduction within APC influences T cell recognition.

  Journal of immunology (Baltimore, Md. : 1950) 20010401

• Evaluation of urinary tract calculi in children.

  Archives of disease in childhood 20010401

• Expression and characterization of von Willebrand factor dimerization defects in different types of von Willebrand disease.

  Blood 20010401

• Blood glutathione and cysteine concentrations in twin children.

  Experimental biology and medicine (Maywood, N.J.) 20010401

• Effect of oxygen on induction of the cystine transporter by bacterial lipopolysaccharide in mouse peritoneal macrophages.

  The Journal of biological chemistry 20010330

• Identification of a novel thioredoxin-related transmembrane protein.

  The Journal of biological chemistry 20010330

• Disulfide bond structure of the AVR9 elicitor of the fungal tomato pathogen Cladosporium fulvum: evidence for a cystine knot.

  Biochemistry 20010327

• Methylmercury inhibits the in vitro uptake of the glutathione precursor, cystine, in astrocytes, but not in neurons.

  Brain research 20010309

• Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein.

  American journal of human genetics 20010301

• Three-dimensional structure of human follicle-stimulating hormone.

  Molecular endocrinology (Baltimore, Md.) 20010301

• [Spider and scorpion toxins as the ion channel blocker].

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20010301

• Occurrence of the Asn45Ser mutation in the GPIX gene in a Belgian patient with Bernard Soulier syndrome.

  Platelets 20010301

• Role of stone analysis in metabolic evaluation and medical treatment of nephrolithiasis.

  Journal of endourology 20010301

• Folding screening assayed by proteolysis: application to various cystine deletion mutants of vascular endothelial growth factor.

  Protein engineering 20010301

• A DNA polymerase with specificity for five base pairs.

  Journal of the American Chemical Society 20010227

• Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM).

  The Journal of biological chemistry 20010223

• [Toxic epidermal necrolysis (drug-induced Lyell's syndrome). 2. Treatment].

  Deutsche medizinische Wochenschrift (1946) 20010216

• CT and stone fragility.

  Journal of endourology 20010201

• [Cystine lithiasis: physiopathology and medical treatment].

  Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie 20010201

• In vitro renaturation of recombinant human pro-urokinase expressed in Escherichia coli.

  Chinese medical journal 20010201

• The role of disulfide bridge in the folding and stability of the recombinant human prion protein.

  The Journal of biological chemistry 20010126

• Pro-sequence assisted folding and disulfide bond formation of human nerve growth factor.

  Journal of molecular biology 20010119

• Intracellular folding pathway of the cystine knot-containing glycoprotein hormone alpha-subunit.

  Biochemistry 20010116

• Diet-induced hyperhomocysteinemia exacerbates neointima formation in rat carotid arteries after balloon injury.

  Circulation 20010102

• The cystine knot motif in toxins and implications for drug design.

  Toxicon : official journal of the International Society on Toxinology 20010101

• Mechanism and significance of increased glutathione level in human hepatocellular carcinoma and liver regeneration.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010101

• Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells.

  Investigative ophthalmology & visual science 20010101

• p-Aminophenol-induced liver toxicity: tentative evidence of a role for acetaminophen.

  Journal of biochemical and molecular toxicology 20010101

• Synthesis of monensin derivatives and their effect on the activity of ricin A-chain immunotoxins.

  Methods in molecular biology (Clifton, N.J.) 20010101

• Effects of metal ions on the oxidation and nitrosation of cysteine residues in proteins and enzymes.

  Metal ions in biological systems 20010101

• Capture and identification of folding intermediates of cystinyl proteins by cyanylation and mass spectrometry.

  Journal of molecular graphics & modelling 20010101

• The amino acid transport system b(o,+) and cystinuria.

  Molecular membrane biology 20010101

• [Leber's hereditary optic neuropathy].

  Vestnik oftalmologii 20010101

• Caldesmon exhibits a clustered distribution along individual chicken gizzard native thin filaments.

  Journal of muscle research and cell motility 20010101

• L-Quisqualic acid transport into hippocampal neurons by a cystine-sensitive carrier is required for the induction of quisqualate sensitization.

  Neuroscience 20010101

• Matrix-assisted laser desorption/ionization time-of-flight mass spectrometric observation of a peptide triplet induced by thermal cleavage of cystine.

  Rapid communications in mass spectrometry : RCM 20010101

• The effect of cysteine on the altered expression of class alpha and mu glutathione S-transferase genes in the rat liver during protein-calorie malnutrition.

  Biochimica et biophysica acta 20001018

• Nitric oxide induces Zn2+ release from metallothionein by destroying zinc-sulphur clusters without concomitant formation of S-nitrosothiol.

  The Biochemical journal 19991115

• Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B.

  The Journal of clinical investigation 19980301

• Isolation, purification, and characterization of the major autolysin from Pseudomonas aeruginosa.

  Canadian journal of microbiology 19971101

• Synthesis and biological evaluation of1',2'-seconucleo-5'- phosphonates.

  Journal of medicinal chemistry 19960301

• Probing the functional conformation of the tridecapeptide mating pheromone of Saccharomyces cerevisiae through study of disulfide-constrained analogs.

  International journal of peptide and protein research 19960301

• The peptide binding site of the substance P (NK-1) receptor localized by a photoreactive analogue of substance P: presence of a disulfide bond.

  Proceedings of the National Academy of Sciences of the United States of America 19960109

• Flavin-dependent alkyl hydroperoxide reductase from Salmonella typhimurium. 2. Cystine disulfides involved in catalysis of peroxide reduction.

  Biochemistry 19960109

• Immunomodulatory activity of conformationally restricted peptides related to TGF-beta-2 90-99 sequence.

  Archivum immunologiae et therapiae experimentalis 19960101

• Urinary excretion of free cystine and the tiopronin-cysteine-mixed disulfide during long term tiopronin treatment of cystinuria.

  Nephron 19950101

• [Results of treatment of cystinuria and cystine lithiasis with alpha-mercaptopropionylglycine. Apropos of 40 patients].

  Journal d'urologie 19940101

• Mode of disulfide bond formation of a heat-stable enterotoxin (STh) produced by a human strain of enterotoxigenic Escherichia coli.

  FEBS letters 19870504

• Management of cystine nephrolithiasis with alpha-mercaptopropionylglycine.

  The Journal of urology 19861101

• Biosynthesis of the sulfonolipid 2-amino-3-hydroxy-15-methylhexadecane-1-sulfonic acid in the gliding bacterium Cytophaga johnsonae.

  Journal of bacteriology 19840701

• The renal clearance of amino acids in cystinuria.

  The Journal of clinical investigation 19670701