57-66-9 | 4-(dipropylsulfamoyl)benzoic acid

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$8.00	$5.00
5g	98%	in stock	$18.00	$12.00
25g	98%	in stock	$69.00	$48.00
100g	98%	in stock	$203.00	$142.00
500g	98%	in stock	$713.00	$499.00

Description

• Catalog Number: AB78599
• Chemical Name: 4-(dipropylsulfamoyl)benzoic acid
• CAS Number: 57-66-9
• Molecular Formula: C13H19NO4S
• Molecular Weight: 285.3593
• MDL Number: MFCD00038402
• SMILES: CCCN(S(=O)(=O)c1ccc(cc1)C(=O)O)CCC

Computed Properties

• Complexity: 374
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 19
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 7
• XLogP3: 3.2

Literature

• Transporter-dependent cytotoxicity of antiviral drugs in primary cultures of human proximal tubular cells.

  Toxicology 20180701

• From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity.

  Toxicological sciences : an official journal of the Society of Toxicology 20180201

• Nitro-fatty acid inhibition of triple-negative breast cancer cell viability, migration, invasion, and tumor growth.

  The Journal of biological chemistry 20180126

• Multiple drug transporters mediate the placental transport of sulpiride.

  Archives of toxicology 20171201

• Interaction between rhein acyl glucuronide and methotrexate based on human organic anion transporters.

  Chemico-biological interactions 20171101

• Inhibition of organic anion transporter (OAT) activity by cigarette smoke condensate.

  Toxicology in vitro : an international journal published in association with BIBRA 20171001

• Gender-specific expression of ATP-binding cassette (Abc) transporters and cytoprotective genes in mouse choroid plexus.

  Toxicology 20170701

• Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine.

  Xenobiotica; the fate of foreign compounds in biological systems 20170401

• Inhibition of SLC drug transporter activities by environmental bisphenols.

  Toxicology in vitro : an international journal published in association with BIBRA 20170401

• Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate.

  Toxicology 20160701

• Inhibiting the Inflammasome: A Chemical Perspective.

  Journal of medicinal chemistry 20160310

• Mechanism of high affinity inhibition of the human urate transporter URAT1.

  Scientific reports 20160101

• Screening to Identify Multidrug Resistance-Associated Protein Inhibitors with Neuroblastoma-Selective Cytotoxicity.

  Biological & pharmaceutical bulletin 20160101

• Toxicological evaluation of acyl glucuronides utilizing half-lives, peptide adducts, and immunostimulation assays.

  Toxicology in vitro : an international journal published in association with BIBRA 20151225

• Effect of uptake transporters OAT3 and OATP1B1 and efflux transporter MRP2 on the pharmacokinetics of eluxadoline.

  Journal of clinical pharmacology 20150501

• Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease.

  Toxicological sciences : an official journal of the Society of Toxicology 20150201

• Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model.

  Neurotoxicology 20140901

• Gene expression regulation of Bcl2, Bax and cytochrome-C by geraniol on chronic MPTP/probenecid induced C57BL/6 mice model of Parkinson's disease.

  Chemico-biological interactions 20140625

• A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.

  Toxicological sciences : an official journal of the Society of Toxicology 20140101

• Evaluation and mechanistic analysis of the cytotoxicity of the acyl glucuronide of nonsteroidal anti-inflammatory drugs.

  Drug metabolism and disposition: the biological fate of chemicals 20140101

• Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates.

  Toxicology 20130915

• p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase.

  Kidney international 20130401

• Targeting organic anion transporter 3 with probenecid as a novel anti-influenza a virus strategy.

  Antimicrobial agents and chemotherapy 20130101

• Uric acid reduction rectifies prehypertension in obese adolescents.

  Hypertension (Dallas, Tex. : 1979) 20121101

• Uricosuric and nephroprotective properties of Ramulus Mori ethanol extract in hyperuricemic mice.

  Journal of ethnopharmacology 20121011

• Challenges associated with the management of gouty arthritis in patients with chronic kidney disease: a systematic review.

  Seminars in arthritis and rheumatism 20121001

• The pharmacokinetics of oxypurinol in people with gout.

  British journal of clinical pharmacology 20120901

• Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice.

  Molecular nutrition & food research 20120901

• Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation.

  Journal of molecular and cellular cardiology 20120701

• Dizziness and rash in an HIV positive man.

  BMJ (Clinical research ed.) 20120628

• TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity.

  American journal of physiology. Cell physiology 20120615

• Transepithelial transport of 4-chloro-2-methylphenoxyacetic acid (MCPA) across human intestinal Caco-2 cell monolayers.

  Basic & clinical pharmacology & toxicology 20120601

• In vivo kinetics of indoxyl sulfate in humans and its renal interaction with angiotensin-converting enzyme inhibitor quinapril in rats.

  The Journal of pharmacology and experimental therapeutics 20120601

• Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

  Journal of medicinal chemistry 20120524

• A role for the organic anion transporter OAT3 in renal creatinine secretion in mice.

  American journal of physiology. Renal physiology 20120515

• In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna.

  Journal of clinical pharmacology 20120401

• Differences in the pharmacokinetics of 4-amino-3-chlorophenyl hydrogen sulfate, a metabolite of resatorvid, in rats and dogs.

  Drug metabolism and disposition: the biological fate of chemicals 20120401

• Pannexin1 drives multicellular aggregate compaction via a signaling cascade that remodels the actin cytoskeleton.

  The Journal of biological chemistry 20120309

• The history and future of probenecid.

  Cardiovascular toxicology 20120301

• Multidrug resistance protein (MRP) 4 attenuates benzo[a]pyrene-mediated DNA-adduct formation in human bronchoalveolar H358 cells.

  Toxicology letters 20120225

• Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3.

  Pharmacological research 20120201

• First evidence of epithelial transport in tardigrades: a comparative investigation of organic anion transport.

  The Journal of experimental biology 20120201

• Organic anion transporters involved in the excretion of bestatin in the kidney.

  Peptides 20120201

• [Transport of limonin in rat intestine in situ and Caco-2 cells in vitro].

  Yao xue xue bao = Acta pharmaceutica Sinica 20120201

• Use of newly available febuxostat in a case of chronic tophaceous gout contraindicated to allopurinol and probenecid.

  The Medical journal of Malaysia 20120201

• Protective compounds in animal models of trigeminal activation and neurodegeneration.

  Ideggyogyaszati szemle 20120130

• Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease.

  Brain research 20120118

• Ethyl-eicosapentaenoate (E-EPA) attenuates motor impairments and inflammation in the MPTP-probenecid mouse model of Parkinson's disease.

  Behavioural brain research 20120115

• Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels.

  Glia 20120101

• Palmitic and linoleic acids induce ER stress and apoptosis in hepatoma cells.

  Lipids in health and disease 20120101

• African American patients with gout: efficacy and safety of febuxostat vs allopurinol.

  BMC musculoskeletal disorders 20120101

• Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy.

  Malaria journal 20120101

• The efficacy and safety of febuxostat for urate lowering in gout patients ≥65 years of age.

  BMC geriatrics 20120101

• Low nasal carriage of drug-resistant bacteria among medical students in Vienna.

  GMS Krankenhaushygiene interdisziplinar 20120101

• Testing for aerobic heterotrophic bacteria allows no prediction of contamination with potentially pathogenic bacteria in the output water of dental chair units.

  GMS Krankenhaushygiene interdisziplinar 20120101

• Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium.

  PloS one 20120101

• The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters.

  The Journal of biological chemistry 20111230

• Risk factors of cellulitis treatment failure with once-daily intravenous cefazolin plus oral probenecid.

  Southern medical journal 20111201

• How clinical and research failures lead to suboptimal prescribing: the example of chronic gout.

  BMJ (Clinical research ed.) 20111201

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• Impact of exercise on mitochondrial transcription factor expression and damage in the striatum of a chronic mouse model of Parkinson's disease.

  Neuroscience letters 20111121

• Micellar electrokinetic chromatographic analysis for in vitro accumulation of anthracyclines enhanced by inhibitors of cell membrane transporter-proteins in cancer cells.

  Biomedical chromatography : BMC 20111001

• Regulation of endocytosis into human brain-microvascular endothelial cells by inhibition of efflux proteins.

  Colloids and surfaces. B, Biointerfaces 20111001

• Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson's disease.

  Pharmacology, biochemistry, and behavior 20111001

• Catastrophic axial gout causing paraplegia in a patient with glycogen storage disease.

  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20111001

• Functional test of multidrug transporter activity in hippocampal-neocortical brain slices from epileptic patients.

  Journal of neuroscience methods 20110915

• Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters.

  Xenobiotica; the fate of foreign compounds in biological systems 20110901

• Allopurinol reduces the lethality associated with acute renal failure induced by Crotalus durissus terrificus snake venom: comparison with probenecid.

  PLoS neglected tropical diseases 20110901

• [Gout - regardless of therapeutic options a 'forgotten' disease].

  Deutsche medizinische Wochenschrift (1946) 20110801

• New bitter blocker discovered, study finds.

  Journal of the American Dental Association (1939) 20110801

• Organic anion and cation transporters are possibly involved in renal excretion of entecavir in rats.

  Life sciences 20110704

• Interactions of human organic anion transporter 1 (hOAT1) with substances associated with forensic toxicology.

  Legal medicine (Tokyo, Japan) 20110701

• G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast.

  Neuropharmacology 20110601

• Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in patients with gout.

  The Journal of rheumatology 20110501

• Organic anion transporter 3 mediates the efflux transport of an amphipathic organic anion, dehydroepiandrosterone sulfate, across the blood-brain barrier in mice.

  Drug metabolism and disposition: the biological fate of chemicals 20110501

• Developing potent human uric acid transporter 1 (hURAT1) inhibitors.

  Journal of medicinal chemistry 20110428

• Parallel regulation of extracellular ATP and inorganic pyrophosphate: roles of growth factors, transduction modulators, and ANK.

  Connective tissue research 20110401

• Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson's disease with moderate neurodegeneration.

  The European journal of neuroscience 20110401

• Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation.

  The Journal of biological chemistry 20110304

• Modulated pharmacokinetics and increased small intestinal toxicity of methotrexate in bilirubin-treated rats.

  The Journal of pharmacy and pharmacology 20110201

• Interactions of urate transporter URAT1 in human kidney with uricosuric drugs.

  Nephrology (Carlton, Vic.) 20110201

• Prevalence of contraindications and prescription of pharmacologic therapies for gout.

  The American journal of medicine 20110201

• Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20110101

• Protective effect of L-kynurenine and probenecid on 6-hydroxydopamine-induced striatal toxicity in rats: implications of modulating kynurenate as a protective strategy.

  Neurotoxicology and teratology 20110101

• [Drug-drug interactions and nephrotoxicity].

  Therapeutische Umschau. Revue therapeutique 20110101

• Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin.

  PloS one 20110101

• Anti-hypertensive effects of probenecid via inhibition of the α-adrenergic receptor.

  Pharmacological reports : PR 20110101

• Decontamination of room air and adjoining wall surfaces by nebulizing hydrogen peroxide.

  GMS Krankenhaushygiene interdisziplinar 20110101

• Involvement of TRPV2 activation in intestinal movement through nitric oxide production in mice.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20101208

• A predictive ligand-based Bayesian model for human drug-induced liver injury.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization.

  American journal of physiology. Cell physiology 20101201

• Pathways for ATP release by bovine ciliary epithelial cells, the initial step in purinergic regulation of aqueous humor inflow.

  American journal of physiology. Cell physiology 20101201

• Crystal arthropathies: recognizing and treating 'the gouch'.

  Primary care 20101201

• [Impact of serum uric acid level on the cardiovascular system as a risk factor].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20101201

• [Treatment of hyperuricemia and gout based on the guideline for the management of hyperuricemia and gout].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20101201

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Effects of probenecid on the pharmacokinetics of mizoribine and co-administration of the two drugs in patients with nephrotic syndrome.

  International journal of clinical pharmacology and therapeutics 20101101

• Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes.

  American journal of physiology. Heart and circulatory physiology 20101001

• Characterization of cellular uptake of perfluorooctanoate via organic anion-transporting polypeptide 1A2, organic anion transporter 4, and urate transporter 1 for their potential roles in mediating human renal reabsorption of perfluorocarboxylates.

  Toxicological sciences : an official journal of the Society of Toxicology 20101001

• Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1).

  The Journal of pharmacology and experimental therapeutics 20100901

• Uric acid increases fibronectin synthesis through upregulation of lysyl oxidase expression in rat renal tubular epithelial cells.

  American journal of physiology. Renal physiology 20100801

• Protective effect of systemic L-kynurenine and probenecid administration on behavioural and morphological alterations induced by toxic soluble amyloid beta (25-35) in rat hippocampus.

  Behavioural brain research 20100711

• cAMP efflux from human trophoblast cell lines: a role for multidrug resistance protein (MRP)1 transporter.

  Molecular human reproduction 20100701

• Modulated function of tissue efflux transporters under hyperbilirubinemia in rats.

  European journal of pharmacology 20100625

• Development and optimization of a high-throughput bioassay for TRPM7 ion channel inhibitors.

  Journal of biomolecular screening 20100601

• Catalpol attenuates MPTP induced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neurotrophic factor in striatum.

  Neuroscience 20100428

• Tenofovir/probenecid combination in HIV/HBV-coinfected patients: how to escape Fanconi syndrome recurrence?

  AIDS (London, England) 20100424

• Biliary efflux transporters involved in the clearance of rosuvastatin in sandwich culture of primary rat hepatocytes.

  Toxicology in vitro : an international journal published in association with BIBRA 20100301

• Multidrug resistance proteins restrain the intestinal absorption of trans-resveratrol in rats.

  The Journal of nutrition 20100301

• Comparative renal excretion of VX-702, a novel p38 MAPK inhibitor, and methotrexate in the perfused rat kidney model.

  Drug development and industrial pharmacy 20100301

• Pharmacokinetic properties and bioequivalence of two compound formulations of 1500 mg ampicillin (1167 mg)/probenecid (333 mg): a randomized-sequence, single-dose, open-label, two-period crossover study in healthy Chinese male volunteers.

  Clinical therapeutics 20100301

• Probenecid treatment enhances retinal and brain delivery of N-4-benzoylaminophenylsulfonylglycine: an anionic aldose reductase inhibitor.

  Brain research bulletin 20100215

• Ultrasonography shows disappearance of monosodium urate crystal deposition on hyaline cartilage after sustained normouricemia is achieved.

  Rheumatology international 20100201

• Extracellular osmolarity modulates G protein-coupled receptor-dependent ATP release from 1321N1 astrocytoma cells.

  American journal of physiology. Cell physiology 20100201

• Competitive inhibition of renal tubular secretion of ciprofloxacin and metabolite by probenecid.

  British journal of clinical pharmacology 20100201

• Masking and manipulation.

  Handbook of experimental pharmacology 20100101

• On call. I've had gout for many years. I used to take Zyloprim without any problems, but I just had a severe allergic reaction, so my doctor switched me to Benemid. I'm doing okay, but the drug sometimes upsets my stomach. Do you have any suggestions?

  Harvard men's health watch 20100101

• Interactions of human organic anion transporters with aristolochic acids.

  Journal of pharmacological sciences 20100101

• [The clinical picture of gout is changing].

  Duodecim; laaketieteellinen aikakauskirja 20100101

• Molecular mechanisms of biliary excretion of cefditoren and the effects of cefditoren on the expression levels of hepatic transporters.

  Drug metabolism and pharmacokinetics 20100101

• Prognostic significance of p53-expression in colorectal carcinoma as measured by a luminometric immunoassay.

  German medical science : GMS e-journal 20100101

• Pannexin 1 contributes to ATP release in airway epithelia.

  American journal of respiratory cell and molecular biology 20091101

• Treatment failure gout.

  Medicine and health, Rhode Island 20091101

• Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy.

  Toxicology 20091001

• Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives.

  Journal of medicinal chemistry 20090910

• Impaired glutamate homeostasis and programmed cell death in a chronic MPTP mouse model of Parkinson's disease.

  Experimental neurology 20090901

• Neuroprotective effects of probenecid in a transgenic animal model of Huntington's disease.

  Journal of neural transmission (Vienna, Austria : 1996) 20090901

• l-kynurenine combined with probenecid and the novel synthetic kynurenic acid derivative attenuate nitroglycerin-induced nNOS in the rat caudal trigeminal nucleus.

  Neuropharmacology 20090901

• Influence of efflux transporters on liver, bile and brain disposition of amitriptyline in mice.

  International journal of pharmaceutics 20090813

• Behavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson's disease.

  Physiology & behavior 20090804

• Opportunities for improving medication use and monitoring in gout.

  Annals of the rheumatic diseases 20090801

• Thrombocytopenia from combination treatment with oseltamivir and probenecid: case report, MedWatch data summary, and review of the literature.

  Pharmacotherapy 20090801

• Neuroprotective effect of long-term NDI1 gene expression in a chronic mouse model of Parkinson disorder.

  Rejuvenation research 20090801

• Probenecid, an inhibitor of transmembrane organic anion transporters, alters tissue distribution of DNA adducts in 1-hydroxymethylpyrene-treated rats.

  Toxicology 20090728

• The effect of probenecid and MK-571 on the feto-maternal transfer of saquinavir in dually perfused human term placenta.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090712

• Evaluation of substrate and inhibitor properties of a novel MDR modulator H17 towards transmembrane efflux pumps.

  European journal of medicinal chemistry 20090701

• Organic anion transporter OAT1 is involved in renal handling of citrulline.

  American journal of physiology. Renal physiology 20090701

• Uptake of metronidazole by human gingival fibroblasts.

  Journal of periodontology 20090601

• Nitric oxide stimulates embryonic somatotroph differentiation and growth hormone mRNA and protein expression through a cyclic guanosine monophosphate-independent mechanism.

  Tissue & cell 20090401

• Esterified trityl radicals as intracellular oxygen probes.

  Free radical biology & medicine 20090401

• Autocrine ATP release coupled to extracellular pyrophosphate accumulation in vascular smooth muscle cells.

  American journal of physiology. Cell physiology 20090401

• Should syphilis be treated differently in HIV-positive and HIV-negative individuals? Treatment outcomes at a university hospital, Brighton, UK.

  International journal of STD & AIDS 20090401

• Thermodynamics of cosolvent action: phenacetin, salicylic acid and probenecid.

  Journal of pharmaceutical sciences 20090301

• The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine.

  Drug metabolism and disposition: the biological fate of chemicals 20090301

• A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis.

  The Journal of biological chemistry 20090213

• Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.

  The Journal of pharmacology and experimental therapeutics 20090201

• Functionality of drug efflux pumps in antimonial resistant Leishmania donovani field isolates.

  Indian journal of biochemistry & biophysics 20090201

• Effects of endurance exercise on ventral tegmental area neurons in the chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and probenecid-treated mice.

  Neuroscience letters 20090130

• Efficacy and tolerability of urate-lowering drugs in gout: a randomised controlled trial of benzbromarone versus probenecid after failure of allopurinol.

  Annals of the rheumatic diseases 20090101

• Low dosage cidofovir without probenecid as treatment for BK virus hamorrhagic cystitis after hemopoietic stem cell transplant.

  The Pediatric infectious disease journal 20090101

• Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration.

  BMC neuroscience 20090101

• Effect of probenecid on kinetics of enrofloxacin in lactating goats after subcutaneous administration.

  Indian journal of experimental biology 20090101

• Adherence with urate-lowering therapies for the treatment of gout.

  Arthritis research & therapy 20090101

• Detection of HER-2/neu, c-myc amplification and p53 inactivation by FISH in Egyptian patients with breast cancer.

  German medical science : GMS e-journal 20090101

• Paclitaxel-resistance conferred by altered expression of efflux and influx transporters for paclitaxel in the human hepatoma cell line, HepG2.

  Drug metabolism and pharmacokinetics 20090101

• Membrane Based Measurement Technology for in situ Monitoring of Gases in Soil.

  Sensors (Basel, Switzerland) 20090101

• Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

  Journal of medicinal chemistry 20081113

• Kynurenine diminishes the ischemia-induced histological and electrophysiological deficits in the rat hippocampus.

  Neurobiology of disease 20081101

• Modelling Parkinson-like neurodegeneration via osmotic minipump delivery of MPTP and probenecid.

  Journal of neurochemistry 20081101

• Influence of cyclic guanosine 3',5' monophosphate modulators on muscle contraction of rat aortas.

  Saudi medical journal 20081101

• Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.

  Journal of medicinal chemistry 20081009

• Evaluation of the selected barrier properties of retinal pigment epithelial cell line ARPE-19 for an in-vitro blood-brain barrier model.

  Human & experimental toxicology 20081001

• Probenecid, a gout remedy, inhibits pannexin 1 channels.

  American journal of physiology. Cell physiology 20080901

• Role of organic anion transporters in the pharmacokinetics of zonampanel, an alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist, in rats.

  Drug metabolism and disposition: the biological fate of chemicals 20080801

• Probenecid, but not cystic fibrosis, alters the total and renal clearance of fexofenadine.

  Journal of clinical pharmacology 20080801

• Population pharmacokinetics of oseltamivir when coadministered with probenecid.

  Journal of clinical pharmacology 20080801

• Capillary electrophoresis of diuretics and probenecid in methanol.

  Journal of chromatography. A 20080711

• Lack of effect of P-glycoprotein inhibition on renal clearance of dicloxacillin in patients with cystic fibrosis.

  Pharmacotherapy 20080701

• Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

  Journal of medicinal chemistry 20080612

• Stroke in pregnancy associated with syphilis.

  The journal of obstetrics and gynaecology research 20080601

• Uric acid lowering therapy: prescribing patterns in a large cohort of older adults.

  Annals of the rheumatic diseases 20080501

• Neuroprotection achieved in the ischaemic rat cortex with L-kynurenine sulphate.

  Life sciences 20080423

• Role of multi-drug resistance-associated protein-1 transporter in statin-induced myopathy.

  Life sciences 20080409

• Pharmacokinetics, tissue distribution and excretion of a new photodynamic drug deuxemether.

  Journal of photochemistry and photobiology. B, Biology 20080328

• Fluorescence-enhanced europium-diethylenetriaminepentaacetic (DTPA)-monoamide complexes for the assessment of renal function.

  Journal of medicinal chemistry 20080227

• Do short-term markers of treatment efficacy predict long-term sequelae of pelvic inflammatory disease?

  American journal of obstetrics and gynecology 20080101

• Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in healthy subjects.

  Clinical pharmacokinetics 20080101

• Mrp2-related efflux of scutellarin in the intestinal absorption in rats.

  Die Pharmazie 20080101

• Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor.

  Drug metabolism and disposition: the biological fate of chemicals 20071201

• Effect of pharmacological lowering of plasma urate on exercise-induced oxidative stress.

  Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 20071201

• Down-regulation of intestinal multidrug resistance-associated protein 2 in long-evans cinnamon rats.

  Drug metabolism and pharmacokinetics 20071201

• Gout: joint pain and more.

  Harvard men's health watch 20071201

• Pharmacokinetics of 3-[125I]iodo-alpha-methyl-L-tyrosine, a tumor imaging agent, after probenecid loading in mice implanted with colon cancer DLD-1 cells.

  Nuclear medicine and biology 20071101

• Management of cellulitis in a pediatric emergency department.

  Pediatric emergency care 20071101

• Effect of probenecid on the biliary excretion of belotecan.

  Archives of pharmacal research 20071101

• Endurance exercise promotes cardiorespiratory rehabilitation without neurorestoration in the chronic mouse model of parkinsonism with severe neurodegeneration.

  Neuroscience 20071012

• Carboxylic acid drug-induced DNA nicking in HEK293 cells expressing human UDP-glucuronosyltransferases: role of acyl glucuronide metabolites and glycation pathways.

  Chemical research in toxicology 20071001

• Transient receptor potential V2 expressed in sensory neurons is activated by probenecid.

  Neuroscience letters 20070925

• Possible involvement of organic anion and cation transporters in renal excretion of xanthine derivatives, 3-methylxanthine and enprofylline.

  Life sciences 20070922

• Biochemical effectiveness of allopurinol and allopurinol-probenecid in previously benzbromarone-treated gout patients.

  Clinical rheumatology 20070901

• Multidrug resistance protein 1 (MRP1) in rabbit conjunctival epithelial cells: its effect on drug efflux and its regulation by adenoviral infection.

  Pharmaceutical research 20070801

• Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2).

  Drug metabolism and disposition: the biological fate of chemicals 20070801

• Probenecid-induced membranous nephropathy.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070801

• Molecular epidemiology of malaria in Cameroon. XXVI. Twelve-year in vitro and molecular surveillance of pyrimethamine resistance and experimental studies to modulate pyrimethamine resistance.

  The American journal of tropical medicine and hygiene 20070801

• Reduction in non-glomerular renal clearance of the caffeine metabolite 1-methylxanthine by probenecid.

  International journal of clinical pharmacology and therapeutics 20070801

• PET-evaluated transport of [11C]hydroxyurea across the rat blood-brain barrier--lack of influence of cyclosporin and probenecid.

  Drug metabolism letters 20070801

• Molecular mechanism of alpha-tocopheryl-phosphate transport across the cell membrane.

  Biochemical and biophysical research communications 20070727

• Isolation and characterization of polyspecific mouse organic solute carrier protein 1 (mOscp1).

  Drug metabolism and disposition: the biological fate of chemicals 20070701

• Impact of genetic knockout of PEPT2 on cefadroxil pharmacokinetics, renal tubular reabsorption, and brain penetration in mice.

  Drug metabolism and disposition: the biological fate of chemicals 20070701

• Identification of molecular compounds critical to Alzheimer's-like plaque formation.

  Journal of neuroscience research 20070701

• Mechanistic study on the intestinal absorption and disposition of baicalein.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070701

• Characterisation of exogenous folate transport in Plasmodium falciparum.

  Molecular and biochemical parasitology 20070701

• Active renal secretion of NXY-059, a novel neuroprotectant, is mediated via an organic acid transporter.

  Journal of clinical pharmacology 20070701

• Electrokinetic migration of acidic drugs across a supported liquid membrane.

  Journal of chromatography. A 20070608

• Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells.

  Drug metabolism and disposition: the biological fate of chemicals 20070601

• Possible multiple transporters were involved in hepatobiliary excretion of antofloxacin in rats.

  Xenobiotica; the fate of foreign compounds in biological systems 20070601

• Prevention of electrical stimulation-induced increase of c-fos immunoreaction in the caudal trigeminal nucleus by kynurenine combined with probenecid.

  Neuroscience letters 20070517

• The pancreatohepatorenal cAMP-adenosine mechanism.

  The Journal of pharmacology and experimental therapeutics 20070501

• Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.

  Current drug metabolism 20070501

• Quantitation of Armillarisin A in human plasma by liquid chromatography-electrospray tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20070411

• Block of CFTR-dependent chloride currents by inhibitors of multidrug resistance-associated proteins.

  European journal of pharmacology 20070410

• Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2).

  Pharmaceutical research 20070401

• One center's experience: the serology and drugs associated with drug-induced immune hemolytic anemia--a new paradigm.

  Transfusion 20070401

• Site-specific bidirectional efflux of 2,4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells.

  The Journal of pharmacy and pharmacology 20070401

• Progesterone inhibits folic acid transport in human trophoblasts.

  The Journal of membrane biology 20070401

• DNA damage caused by benzo(a)pyrene in MCF-7 cells is increased by verapamil, probenecid and PSC833.

  Toxicology letters 20070227

• Chiral recognition of amethopterin enantiomers by the reduced folate carrier in Caco-2 cells.

  Drug metabolism and pharmacokinetics 20070225

• Schisandrin B: a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1.

  Cancer letters 20070208

• Evidence of Oatp and Mdr1 in cryopreserved rat hepatocytes.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070201

• Efflux of drugs and solutes from brain: the interactive roles of diffusional transcapillary transport, bulk flow and capillary transporters.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070101

• Kynurenine in combination with probenecid mitigates the stimulation-induced increase of c-fos immunoreactivity of the rat caudal trigeminal nucleus in an experimental migraine model.

  Journal of neural transmission (Vienna, Austria : 1996) 20070101

• In silico prediction of pregnane X receptor activators by machine learning approaches.

  Molecular pharmacology 20070101

• [A case of papillitis revealing primary syphilis].

  Medecine et maladies infectieuses 20070101

• Mitoxantrone permeability in MDCKII cells is influenced by active influx transport.

  Molecular pharmaceutics 20070101

• Flow cytometric monitoring of multidrug drug resistance protein 1 (MRP1/ABCC1) -mediated transport of 2',7'-bis-(3-carboxypropyl)-5-(and-6)- carboxyfluorescein (BCPCF) into human erythrocyte membrane inside-out vesicles.

  Molecular membrane biology 20070101

• [Diagnosis of interstitial nephropathy caused by BK virus in renal transplantation. Therapeutic management with cidofovir plus probenecid].

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20070101

• Verapamil, but not probenecid, co-administration can convert desloratadine to a sedating antihistamine in mice.

  Drug metabolism letters 20070101

• High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid.

  Circulation 20061205

• Schistosoma mansoni: biochemical characterization of lactate transporters or similar proteins.

  Experimental parasitology 20061101

• Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.

  The Journal of pharmacy and pharmacology 20061101

• Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction.

  Drug metabolism and disposition: the biological fate of chemicals 20061001

• Comparison of permeation enhancing strategies for an oral factor Xa inhibitor using the Caco-2 cell monolayer model.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20061001

• Potential gamma-hydroxybutyric acid (GHB) drug interactions through blood-brain barrier transport inhibition: a pharmacokinetic simulation-based evaluation.

  Journal of pharmacokinetics and pharmacodynamics 20061001

• Function of multidrug resistance-associated protein 2 in acute hepatic failure rats.

  European journal of pharmacology 20060928

• Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes.

  Epilepsy research 20060901

• Membrane transporter proteins: a challenge for CNS drug development.

  Dialogues in clinical neuroscience 20060901

• Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20).

  American journal of physiology. Renal physiology 20060801

• The efflux of flavonoids morin, isorhamnetin-3-O-rutinoside and diosmetin-7-O-beta-D-xylopyranosyl-(1-6) -beta-D-glucopyranoside in the human intestinal cell line caco-2.

  Pharmaceutical research 20060801

• A blistering disease: bullous erysipelas.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20060801

• Efficacy of probenecid for a patient with juvenile dermatomyositis complicated with calcinosis.

  The Journal of rheumatology 20060801

• Apparent active transport of MDMA is not mediated by P-glycoprotein: a comparison with MDCK and Caco-2 monolayers.

  Biopharmaceutics & drug disposition 20060701

• Tubular transporters and clearance of adefovir.

  European journal of pharmacology 20060701

• Human vascular smooth muscle cells express a urate transporter.

  Journal of the American Society of Nephrology : JASN 20060701

• Subchronic treatment with kynurenine and probenecid: effects on prepulse inhibition and firing of midbrain dopamine neurons.

  Journal of neural transmission (Vienna, Austria : 1996) 20060501

• A phase I clinical pharmacologic study of pralatrexate in combination with probenecid in adults with advanced solid tumors.

  Cancer chemotherapy and pharmacology 20060501

• Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid.

  Drug metabolism and disposition: the biological fate of chemicals 20060501

• Transfer of probenecid and cephalexin into breast milk.

  The Annals of pharmacotherapy 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Carrier-mediated processes at several rat brain interfaces determine the neuropharmacokinetics of morphine and morphine-6-beta-D-glucuronide.

  Life sciences 20060411

• Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060401

• Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists.

  The Journal of pharmacology and experimental therapeutics 20060301

• Probenecid with oseltamivir for human influenza A (H5N1) virus infection?

  The New England journal of medicine 20060223

• In vivo and in vitro modulation of MDR molecules in murine thymocytes.

  International immunopharmacology 20060201

• Intermediate-dose cidofovir without probenecid in the treatment of BK virus allograft nephropathy.

  Pediatric transplantation 20060201

• [Molecular mechanism in biological transport in the kidney: Urate transporter URAT1].

  Nihon rinsho. Japanese journal of clinical medicine 20060201

• A concise history of gout and hyperuricemia and their treatment.

  Arthritis research & therapy 20060101

• Elevated reactive oxygen species but not glutathione regulate mercury resistance to AML-2/DX100 cells.

  Immunopharmacology and immunotoxicology 20060101

• Febuxostat--treatment for hyperuricemia and gout?

  The New England journal of medicine 20051208

• Transepithelial transport of fluorescent p-glycoprotein and MRP2 substrates by insect Malpighian tubules: confocal microscopic analysis of secreted fluid droplets.

  The Journal of experimental biology 20051201

• Wartime tactic doubles power of scarce bird-flu drug.

  Nature 20051103

• Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules.

  The Journal of pharmacology and experimental therapeutics 20051101

• Handling of the homocysteine S-conjugate of methylmercury by renal epithelial cells: role of organic anion transporter 1 and amino acid transporters.

  The Journal of pharmacology and experimental therapeutics 20051101

• Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity.

  Drug metabolism and disposition: the biological fate of chemicals 20051101

• An update on the treatment options for gout and calcium pyrophosphate deposition.

  Expert opinion on pharmacotherapy 20051101

• Transepithelial urate transport by avian renal proximal tubule epithelium in primary culture.

  The Journal of experimental biology 20051101

• [Tubular transporters OAT1 and MRP2 and clearance of adefovir].

  Nephrologie & therapeutique 20051101

• A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters.

  The Journal of pharmacology and experimental therapeutics 20051001

• Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20051001

• Handling of cysteine S-conjugates of methylmercury in MDCK cells expressing human OAT1.

  Kidney international 20051001

• Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats.

  Epilepsia 20051001

• MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid.

  International journal of cancer 20050920

• Transport of N-acetylcysteine s-conjugates of methylmercury in Madin-Darby canine kidney cells stably transfected with human isoform of organic anion transporter 1.

  The Journal of pharmacology and experimental therapeutics 20050901

• Effects of active transport of 5-hydroxyindoleacetic acid on measures of serotonin metabolism in the brain.

  Neuroscience and behavioral physiology 20050901

• Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids.

  Life sciences 20050826

• Phenolsulfonphthalein transport by potential-sensitive urate transport system.

  European journal of pharmacology 20050822

• Functional involvement of rat organic anion transporter 2 (Slc22a7) in the hepatic uptake of the nonsteroidal anti-inflammatory drug ketoprofen.

  Drug metabolism and disposition: the biological fate of chemicals 20050801

• Mrp2/Abcc2 transport activity is stimulated by protein kinase Calpha in a baculo virus co-expression system.

  Life sciences 20050617

• Effect of probenecid on the pharmacokinetics of carbamazepine in healthy subjects.

  European journal of clinical pharmacology 20050601

• Specificity of the fluorescein transport process in Malpighian tubules of the cricket Acheta domesticus.

  The Journal of experimental biology 20050601

• Prediction of genotoxicity of chemical compounds by statistical learning methods.

  Chemical research in toxicology 20050601

• Functional expression of pig renal organic anion transporter 3 (pOAT3).

  Biochimie 20050501

• The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.

  Molecular cancer therapeutics 20050501

• Systemically administered glucosamine-kynurenic acid, but not pure kynurenic acid, is effective in decreasing the evoked activity in area CA1 of the rat hippocampus.

  European journal of pharmacology 20050418

• Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects.

  American journal of physiology. Renal physiology 20050401

• UDP-glucuronosyltransferases and clinical drug-drug interactions.

  Pharmacology & therapeutics 20050401

• Expression and activity of multidrug resistance protein 1 in a murine thymoma cell line.

  Immunology 20050401

• Altered brain penetration of diclofenac and mefenamic acid, but not acetaminophen, in Shiga-like toxin II-treated mice.

  Journal of pharmacological sciences 20050401

• Absorption of fumonisin B1 and aminopentol on an in vitro model of intestinal epithelium; the role of P-glycoprotein.

  Toxicon : official journal of the International Society on Toxinology 20050301

• Synthesis and biological testing of aminoxyls designed for long-term retention by living cells.

  Organic & biomolecular chemistry 20050221

• Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11).

  Molecular pharmacology 20050201

• Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis.

  Journal of medical virology 20050201

• Role of two adjacent cytoplasmic tyrosine residues in MRP1 (ABCC1) transport activity and sensitivity to sulfonylureas.

  Biochemical pharmacology 20050201

• Characterization of secretory intestinal transport of phenolsulfonphthalein.

  Drug metabolism and pharmacokinetics 20050201

• Mercury induces multidrug resistance-associated protein gene through p38 mitogen-activated protein kinase.

  Toxicology letters 20050115

• Pharmacology of drugs for hyperuricemia. Mechanisms, kinetics and interactions.

  Contributions to nephrology 20050101

• Potential utility of natural polyphenols for reversing fat-induced insulin resistance.

  Medical hypotheses 20050101

• Influence of probenecid on the delivery of morphine-6-glucuronide to the brain.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050101

• Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics.

  Clinical pharmacology and therapeutics 20050101

• The outcome of oropharyngeal gonorrhoea treatment with different regimens.

  International journal of STD & AIDS 20050101

• Inhibition of MRP1-mediated efflux in human erythrocytes by mono-anionic bile salts.

  Anticancer research 20050101

• Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter.

  American journal of nephrology 20050101

• Multidrug resistance-associated protein 2 (MRP2) affects hepatobiliary elimination but not the intestinal disposition of tenofovir disoproxil fumarate and its metabolites.

  Xenobiotica; the fate of foreign compounds in biological systems 20050101

• Beta-trace protein (prostaglandin D synthase)--a stable and reliable protein in perilymph.

  German medical science : GMS e-journal 20050101

• Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.

  British journal of pharmacology 20041201

• Probenecid interacts with the pharmacokinetics of morphine-6-glucuronide in humans.

  Anesthesiology 20041201

• Comparative effects of pyrimethamine-sulfadoxine, with and without probenecid, on Plasmodium falciparum gametocytes in children with acute, uncomplicated malaria.

  Annals of tropical medicine and parasitology 20041201

• Astroglial plasticity and glutamate function in a chronic mouse model of Parkinson's disease.

  Experimental neurology 20041101

• Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter.

  Journal of the American Society of Nephrology : JASN 20041101

• Kynurenine administered together with probenecid markedly inhibits pentylenetetrazol-induced seizures. An electrophysiological and behavioural study.

  Neuropharmacology 20041101

• Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier.

  Endocrinology 20040901

• Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3.

  Drug metabolism and disposition: the biological fate of chemicals 20040901

• Monocarboxylate transport inhibition alters retinal function and cellular amino acid levels.

  The European journal of neuroscience 20040901

• An integrated model for the analysis of pharmacokinetic data from microdialysis experiments.

  Pharmaceutical research 20040901

• Syphilis in the HIV-infected patient: an update on epidemiology, diagnosis, and management.

  Current HIV/AIDS reports 20040901

• Endogenous kynurenic acid disrupts prepulse inhibition.

  Biological psychiatry 20040815

• Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney.

  American journal of physiology. Renal physiology 20040801

• ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages.

  Antiviral therapy 20040801

• [Synthesis of polymeric drug nanomicrospheres containing probenecid].

  Guang pu xue yu guang pu fen xi = Guang pu 20040801

• The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter.

  The Journal of physiology 20040615

• Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier.

  The Journal of pharmacology and experimental therapeutics 20040601

• Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia.

  The Journal of pharmacology and experimental therapeutics 20040601

• Evaluation and comparison of MRP1 activity with three fluorescent dyes and three modulators in leukemic cell lines.

  Leukemia research 20040601

• Renal secretion of the antiviral nucleoside analog AM188 is inhibited by probenecid, p-aminohippuric acid, and cimetidine in the isolated perfused rat kidney.

  Pharmaceutical research 20040601

• Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023.

  Cancer chemotherapy and pharmacology 20040501

• Localization of heparin and low-molecular-weight heparin in the rat kidney.

  Thrombosis and haemostasis 20040501

• Open randomized study of pyrimethamine-sulphadoxine vs. pyrimethamine-sulphadoxine plus probenecid for the treatment of uncomplicated Plasmodium falciparum malaria in children.

  Tropical medicine & international health : TM & IH 20040501

• Hepatobiliary excretion of berberine.

  Drug metabolism and disposition: the biological fate of chemicals 20040401

• Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid.

  Drug metabolism and disposition: the biological fate of chemicals 20040401

• [Role of active transport of 5-hydroxyindoleacetic acid in serotonin metabolism in the brain].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20040401

• Mediation of annexin 1 secretion by a probenecid-sensitive ABC-transporter in rat inflamed mucosa.

  Biochemical pharmacology 20040315

• Once-daily cefazolin and probenecid for skin and soft tissue infections.

  The Annals of pharmacotherapy 20040301

• Pharmacological activation of plasma-membrane KATP channels reduces reoxygenation-induced Ca(2+) overload in cardiac myocytes via modulation of the diastolic membrane potential.

  British journal of pharmacology 20040301

• Therapeutic potential of folate uptake inhibition in Plasmodium falciparum.

  Trends in parasitology 20040301

• Production and role of extracellular guanosine cyclic 3', 5' monophosphate in sodium uptake in human proximal tubule cells.

  Hypertension (Dallas, Tex. : 1979) 20040201

• Function and localization of urate transporter 1 in mouse kidney.

  Journal of the American Society of Nephrology : JASN 20040201

• [Therapy of syphilis].

  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20040201

• Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine.

  Journal of pharmacological sciences 20040201

• Inhibition of multidrug transporters by verapamil or probenecid does not alter blood-brain barrier penetration of levetiracetam in rats.

  Epilepsy research 20040201

• Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion.

  Journal of the American Society of Nephrology : JASN 20040101

• Transport of 99mTc-MAG3 via rat renal organic anion transporter 1.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20040101

• Valproic acid uptake by bovine brain microvessel endothelial cells: role of active efflux transport.

  Epilepsy research 20040101

• Cryptosporidium parvum: effect of multi-drug reversing agents on the expression and function of ATP-binding cassette transporters.

  Experimental parasitology 20040101

• Hyperuricaemia and preeclampsia: is there a pathogenic link?

  Medical hypotheses 20040101

• Bodipy-FL-verapamil: a fluorescent probe for the study of multidrug resistance proteins.

  Cellular oncology : the official journal of the International Society for Cellular Oncology 20040101

• Two male siblings with hereditary renal hypouricemia and exercise-induced ARF.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20031201

• Potential roles of P-gp and calcium channels in loperamide and diphenoxylate transport.

  Toxicology and applied pharmacology 20031115

• Effect of probenecid and quinidine on the transport of alovudine (3'-fluorothymidine) to the rat brain studied by microdialysis.

  Pharmacology & toxicology 20031101

• Multidrug-resistant tumor cells remain sensitive to a recombinant interleukin-4-Pseudomonas exotoxin, except when overexpressing the multidrug resistance protein MRP1.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20031015

• Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites.

  Biochemical and biophysical research communications 20031010

• Functional expression of the multidrug resistance protein 1 in microglia.

  The Journal of pharmacology and experimental therapeutics 20031001

• Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro.

  Neuropharmacology 20031001

• Sources for superoxide release: lessons from blockade of electron transport, NADPH oxidase, and anion channels in diaphragm.

  Antioxidants & redox signaling 20031001

• Regulated secretion of macrophage migration inhibitory factor is mediated by a non-classical pathway involving an ABC transporter.

  FEBS letters 20030911

• Evidence for an active transport of morphine-6-beta-d-glucuronide but not P-glycoprotein-mediated at the blood-brain barrier.

  Journal of neurochemistry 20030901

• Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane.

  Hepatology (Baltimore, Md.) 20030801

• UV or X-irradiation increases the cytoplasmic accumulation of rhodamine 123 in various cancer cell lines.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20030801

• Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions.

  The Journal of biological chemistry 20030627

• Apparent lack of Mrp1-mediated efflux at the luminal side of mouse blood-brain barrier endothelial cells.

  Pharmaceutical research 20030601

• Probenecid-induced changes in the clearance of pranoprofen enantiomers.

  Chirality 20030505

• Effect of chronic probenecid therapy on cefazolin serum concentrations.

  The Annals of pharmacotherapy 20030501

• Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient.

  American journal of physiology. Renal physiology 20030401

• Control of hepatocyte DNA synthesis by intracellular pH and its role in the action of tumor promoters.

  Journal of cellular physiology 20030401

• An artificial amino acid, 4-iodo-L-meta-tyrosine: biodistribution and excretion via kidney.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030401

• Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20030401

• ATP released from astrocytes during swelling activates chloride channels.

  Journal of neurophysiology 20030401

• Morphine blood-brain barrier transport is influenced by probenecid co-administration.

  Pharmaceutical research 20030401

• Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics.

  European journal of pharmacology 20030328

• Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine kidney cells.

  Molecular pharmacology 20030301

• Sulfate conjugating and transport functions of MDCK distal tubular cells.

  Kidney international 20030301

• Pharmacokinetics of 5 (and 6)-carboxy-2',7'-dichlorofluorescein and its diacetate promoiety in the liver.

  The Journal of pharmacology and experimental therapeutics 20030201

• Transport of 5-formyltetrahydrofolate into primary cultured rat astrocytes.

  Archives of biochemistry and biophysics 20030201

• Mechanisms by which 2',3'-dideoxyinosine (ddI) crosses the guinea-pig CNS barriers; relevance to HIV therapy.

  Journal of neurochemistry 20030201

• Interaction of ibuprofen and probenecid with drug metabolizing enzyme phenotyping procedures using caffeine as the probe drug.

  British journal of clinical pharmacology 20030201

• Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites.

  Chemico-biological interactions 20030106

• Prolactin regulation of the pendrin-iodide transporter in the mammary gland.

  American journal of physiology. Endocrinology and metabolism 20030101

• Urate transport via human PAH transporter hOAT1 and its gene structure.

  Kidney international 20030101

• Pharmacokinetics and renal effects of cidofovir with a reduced dose of probenecid in HIV-infected patients with cytomegalovirus retinitis.

  Journal of clinical pharmacology 20030101

• No-wash dyes for calcium flux measurement.

  BioTechniques 20030101

• Endometritis does not predict reproductive morbidity after pelvic inflammatory disease.

  American journal of obstetrics and gynecology 20030101

• Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats.

  Pharmaceutical research 20030101

• [Drug therapy for idiopathic hyperuricemia--introduction, dose, and side effects].

  Nihon rinsho. Japanese journal of clinical medicine 20030101

• [Molecular mechanism for urinary excretion of hypoxanthine and xanthine].

  Nihon rinsho. Japanese journal of clinical medicine 20030101

• Effect of the dimeric bile acid analogue S 0960, a specific inhibitor of the apical sodium-dependent bile salt transporter in the ileum, on the renal handling of taurocholate.

  Arzneimittel-Forschung 20030101

• Stability, cellular uptake, biotransformation, and efflux of tea polyphenol (-)-epigallocatechin-3-gallate in HT-29 human colon adenocarcinoma cells.

  Cancer research 20021215

• Single-cell image analysis to assess ABC-transporter-mediated efflux in highly purified hematopoietic progenitors.

  Cytometry 20021201

• Screening for 18 diuretics and probenecid in doping analysis by liquid chromatography-tandem mass spectrometry.

  Biomedical chromatography : BMC 20021201

• p-Aminohippurate transport at the apical membrane in the OK kidney epithelial cell line.

  Pharmaceutical research 20021201

• Lyme disease.

  Clinical evidence 20021201

• Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease.

  Brain research 20021122

• Tumour cell uptake of the metastasis inhibitor ruthenium complex NAMI-A and its in vitro effects on KB cells.

  Cancer chemotherapy and pharmacology 20021101

• Involvement of multidrug resistance proteins (MDR) in the modulation of glucocorticoid response.

  The Journal of steroid biochemistry and molecular biology 20021101

• Functional analysis of ABCA8, a new drug transporter.

  Biochemical and biophysical research communications 20021018

• Disposition of acamprosate in the rat: influence of probenecid.

  Biopharmaceutics & drug disposition 20021001

• The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1).

  AIDS (London, England) 20020906

• Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1.

  Journal of pineal research 20020901

• Chronic arsenic-exposed human prostate epithelial cells exhibit stable arsenic tolerance: mechanistic implications of altered cellular glutathione and glutathione S-transferase.

  Toxicology and applied pharmacology 20020901

• Reduced gastrointestinal toxicity following inhibition of the biliary excretion of irinotecan and its metabolites by probenecid in rats.

  Pharmaceutical research 20020901

• The influence of inhibition of probenecid sensitive transporters on the central nervous system (CNS) uptake and the antinociceptive activity of morphine-6-glucuronide in rats.

  Neuroscience letters 20020830

• Characterization of methotrexate transport and its drug interactions with human organic anion transporters.

  The Journal of pharmacology and experimental therapeutics 20020801

• Differential effects of p-glycoprotein and multidrug resistance protein-1 on productive human immunodeficiency virus infection.

  The Journal of infectious diseases 20020801

• Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice.

  The Journal of biological chemistry 20020726

• CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20020701

• Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity.

  Journal of the American Society of Nephrology : JASN 20020701

• Outpatient pelvic inflammatory disease treatment as effective as inpatient care, study finds.

  Report on medical guidelines & outcomes research 20020614

• Role of human organic anion transporter 4 in the transport of ochratoxin A.

  Biochimica et biophysica acta 20020612

• Once-daily intravenous cefazolin plus oral probenecid is equivalent to once-daily intravenous ceftriaxone plus oral placebo for the treatment of moderate-to-severe cellulitis in adults.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020601

• Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors.

  The Journal of pharmacology and experimental therapeutics 20020601

• Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.

  Cancer research 20020601

• Methylmercury accumulation and fluxes across the intestine of channel catfish, Ictalurus punctatus.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020601

• Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6).

  The Journal of biological chemistry 20020510

• Neotrofin is transported out of brain by a saturable mechanism: possible involvement of multidrug resistance and monocarboxylic acid transporters.

  Drug metabolism and disposition: the biological fate of chemicals 20020501

• Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus.

  Molecular pharmacology 20020501

• Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney.

  Kidney international 20020501

• 99mTc-N, N'-bis(aminoethyl)propanediamine hexaacetic acid (BPHA): a glomerular filtration agent similar to 99mTc-DTPA.

  Nuclear medicine and biology 20020501

• The influence of P-glycoprotein on morphine transport in Caco-2 cells. Comparison with paclitaxel.

  European journal of pharmacology 20020405

• Mapping of local renal blood flow with PET and H(2)(15)O.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20020401

• Contributions of saturable active secretion, passive transcellular, and paracellular diffusion to the overall transport of furosemide across adenocarcinoma (Caco-2) cells.

  Journal of pharmaceutical sciences 20020401

• Mechanism and regulation of vitamin B(6) uptake by renal tubular epithelia: studies with cultured OK cells.

  American journal of physiology. Renal physiology 20020301

• The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP.

  Journal of the American Society of Nephrology : JASN 20020301

• Human organic anion transporters and human organic cation transporters mediate renal antiviral transport.

  The Journal of pharmacology and experimental therapeutics 20020301

• Budesonide reduces multidrug resistance-associated protein 1 expression in an airway epithelial cell line (Calu-1).

  European journal of pharmacology 20020215

• Evaluation of the clinical relevance of the expression and function of P-glycoprotein, multidrug resistance protein and lung resistance protein in patients with primary acute myelogenous leukemia.

  Leukemia research 20020201

• [Hyperuricemia and gout--treatment].

  Deutsche medizinische Wochenschrift (1946) 20020201

• The distribution of the anti-HIV drug, 2'3'-dideoxycytidine (ddC), across the blood-brain and blood-cerebrospinal fluid barriers and the influence of organic anion transport inhibitors.

  Journal of neurochemistry 20020201

• The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies.

  Drug metabolism and disposition: the biological fate of chemicals 20020101

• Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in goats given enrofloxacin alone and in combination with probenecid.

  Veterinary journal (London, England : 1997) 20020101

• Cidofovir-induced end-stage renal failure.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20020101

• The effects of probenecid on the disposition of risperidone and olanzapine in healthy volunteers.

  Clinical pharmacology and therapeutics 20020101

• Transport of methotrexate into LNCaP human prostate cancer cells.

  BioFactors (Oxford, England) 20020101

• The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites.

  Drug metabolism and pharmacokinetics 20020101

• Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).

  The Journal of biological chemistry 20011207

• P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain.

  Neuroreport 20011116

• Interleukin-1beta stimulates cyclic GMP efflux in brain astrocytes.

  FEBS letters 20011102

• Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule.

  The Journal of pharmacology and experimental therapeutics 20011101

• Interaction of 2,3-dimercapto-1-propane sulfonate with the human organic anion transporter hOAT1.

  The Journal of pharmacology and experimental therapeutics 20011101

• Effect of probenecid on fluorescein transport in the central nervous system using in vitro and in vivo models.

  Pharmaceutical research 20011101

• Cidofovir as primary pre-emptive therapy for post-transplant cytomegalovirus infections.

  Bone marrow transplantation 20011101

• Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome.

  The Journal of biological chemistry 20011005

• Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport.

  Cancer research 20011001

• Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier.

  Journal of neurochemistry 20011001

• Uraemia suppresses central dopaminergic metabolism and impairs motor activity in rats.

  Intensive care medicine 20011001

• Sex-related differences in the renal disposition of the acidic metabolite of clentiazem in rat.

  Xenobiotica; the fate of foreign compounds in biological systems 20011001

• Influence of multidrug resistance (MDR) proteins at the blood-brain barrier on the transport and brain distribution of enaminone anticonvulsants.

  Journal of pharmaceutical sciences 20011001

• Characterization of ochratoxin A transport by human organic anion transporters.

  Life sciences 20010921

• Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1.

  American journal of physiology. Renal physiology 20010901

• Induction of chemoresistance in HL-60 cells concomitantly causes a resistance to apoptosis and the synthesis of P-glycoprotein.

  Leukemia 20010901

• Effect of probenecid on ventricular cerebrospinal fluid methotrexate pharmacokinetics after intralumbar administration in nonhuman primates.

  Cancer chemotherapy and pharmacology 20010901

• Effect of acetazolamide on outward permeability of blood-retina barrier using differential vitreous flyorophotometry.

  Current eye research 20010901

• Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain.

  Neuroreport 20010808

• Nifedipine modulation of biliary GSH and GSSG/ conjugate efflux in normal and regenerating rat liver.

  American journal of physiology. Gastrointestinal and liver physiology 20010701

• Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier.

  The Journal of pharmacology and experimental therapeutics 20010701

• Transport of fluorescein in MDCKII-MRP1 transfected cells and mrp1-knockout mice.

  Biochemical and biophysical research communications 20010622

• Effect of capillary efflux transport inhibition on the determination of probe recovery during in vivo microdialysis in the brain.

  The Journal of pharmacology and experimental therapeutics 20010601

• Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters.

  European journal of pharmacology 20010511

• Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.

  Molecular pharmacology 20010501

• Probenecid-associated alterations in valproic acid pharmacokinetics in rats: can in vivo disposition of valproate glucuronide be predicted from in vitro formation data?

  Drug metabolism and disposition: the biological fate of chemicals 20010501

• Double-edged sword of chemosensitizer: increase of multidrug resistance protein (MRP) in leukemic cells by an MRP inhibitor probenecid.

  Biochemical and biophysical research communications 20010427

• Probenecid-associated alterations in valproate glucuronide hepatobiliary disposition: mechanistic assessment using mathematical modeling.

  The Journal of pharmacology and experimental therapeutics 20010401

• Furosemide-probenecid interaction as a laboratory exercise for undergraduate education in clinical pharmacology.

  Clinical pharmacology and therapeutics 20010401

• Assessment of active transport of HIV protease inhibitors in various cell lines and the in vitro blood--brain barrier.

  AIDS (London, England) 20010309

• A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells.

  Pharmaceutical research 20010201

• Interactions between cimetidine, nitrofurantoin, and probenecid active transport into rat milk.

  The Journal of pharmacology and experimental therapeutics 20010101

• Effects of probenecid on renal function in surgical patients anesthetized with low-flow sevoflurane.

  Anesthesiology 20010101

• Secretory transport of p-aminohippuric acid across intestinal epithelial cells in Caco-2 cells and isolated intestinal tissue.

  The Journal of pharmacy and pharmacology 20010101

• Identification of an organic anion transport system in the human colon carcinoma cell line HT29 clone 19A.

  Pflugers Archiv : European journal of physiology 20010101

• Effect of probenecid on the kinetics of a single oral 400mg dose of moxifloxacin in healthy male volunteers.

  Clinical pharmacokinetics 20010101

• Mouse model of Parkinsonism: a comparison between subacute MPTP and chronic MPTP/probenecid treatment.

  Neuroscience 20010101

• The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides.

  The Journal of biological chemistry 20000929

• Subjective sensation of heaviness in gout patients.

  Hiroshima journal of medical sciences 20000601

• Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions.

  Molecular pharmacology 20000401

• Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta.

  The Journal of biological chemistry 20000211

• Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.

  Kidney international 19991201

• Transport of ochratoxin A by renal multispecific organic anion transporter 1.

  The Journal of pharmacology and experimental therapeutics 19990601

• Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain.

  The Journal of biological chemistry 19990507

• Restoration of the uricosuric effect of probenecid after triglycylvasopressine administration in a gouty patient.

  Clinical nephrology 19981001

• Role of the renal cysteine conjugate beta-lyase pathway in inhaled compound A nephrotoxicity in rats.

  Anesthesiology 19980601

• The nephrotoxicity and hepatotoxicity of 1,1,2,2-tetrafluoroethyl-L-cysteine in the rat.

  Archives of toxicology 19980501

• Randomized, controlled study of the safety and efficacy of intravenous cidofovir for the treatment of relapsing cytomegalovirus retinitis in patients with AIDS.

  Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 19980401

• Mixed effects of 2,6-dithiopurine against cyclophosphamide mediated bladder and lung toxicity in mice.

  Toxicology 19980116

• Expression of the multidrug resistance-associated protein (MRP) and chemoresistance of human non-small-cell lung cancer cells.

  International journal of cancer 19970926

• Possible role of the multidrug resistance-associated protein (MRP) in chemoresistance of human melanoma cells.

  International journal of cancer 19970328

• Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells.

  Cancer chemotherapy and pharmacology 19970101

• Transport of the antiviral nucleoside analogs 3'-azido-3'-deoxythymidine and 2',3'-dideoxycytidine by a recombinant nucleoside transporter (rCNT) expressed in Xenopus laevis oocytes.

  Molecular pharmacology 19960801

• Renal handling of urate in a patient with familial juvenile gouty nephropathy.

  Internal medicine (Tokyo, Japan) 19960701

• Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions.

  Proceedings of the National Academy of Sciences of the United States of America 19960528

• Pharmacokinetics of bacampicillin in equids.

  American journal of veterinary research 19951101

• Nephrotoxicity of 4-amino-3-S-glutathionylphenol and its modulation by metabolism or transport inhibitors.

  Archives of toxicology 19940101

• Renal hypouricemia due to enhanced tubular secretion of urate associated with urolithiasis: successful treatment of urolithiasis by alkalization of urine K+, Na(+)-citrate.

  Nephron 19930101

• In vivo nephrotoxic action of an isomeric mixture of S-(1-phenyl-2-hydroxyethyl)glutathione and S-(2-phenyl-2-hydroxyethyl)glutathione in Fischer-344 rats.

  Toxicology 19910325

• Probenecid and zidovudine metabolism.

  Lancet (London, England) 19890826

• Probenecid induced immune hemolytic anemia.

  The Journal of rheumatology 19860201

• Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity.

  Biochemical pharmacology 19860115

• The mechanisms of target cell injury by nephrotoxins.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 19860101

• Immune hemolytic anemia associated with probenecid.

  American journal of clinical pathology 19850901

• Role of renal metabolism and excretion in 5-nitrofuran-induced uroepithelial cancer in the rat.

  The Journal of clinical investigation 19850901

• Enhancement of cisplatin nephrotoxicity by probenecid.

  Cancer treatment reports 19840201

• One gram of cefoxitin cures uncomplicated gonococcal urethritis caused by penicillinase-producing Neisseria gonorrhoeae (PPNG).

  Sexually transmitted diseases 19830101

• Treatment of gonorrhea: comparison of cefotaxime and penicillin.

  Antimicrobial agents and chemotherapy 19810501

• Homovanilic acid in Huntington's disease and Sydenham's chorea.

  Journal of neurology, neurosurgery, and psychiatry 19810301

• Effect of probenecid on the natriuresis and renin release induced by bumetanide in man.

  Journal of clinical pharmacology 19810101

• Use of probenecid in ticarcillin-induced hypokalemia.

  Clinical therapeutics 19800101

• Skin sensitizing properties of arylalcanoic acids and their analogues.

  Contact dermatitis 19790901

• Potentiation of haloperidol-induced catalepsy by dopamine agonists: possible involvement of central 5-hydroxytryptamine.

  Pharmacology, biochemistry, and behavior 19790401

• Transient hyperkinesia after a single intravenous perfusion of diphenylhydantoin. Report of a case associated with nontoxic plasma levels of diphenylhydantoin.

  European neurology 19790101

• Studies on the modification of renal lesions due to aspirin and oxyphenbutazone in the rat and the effects on the kidney of 2:4 dinitrophenol.

  Pathology 19760701

• Cephalexin-related nephropathy.

  JAMA 19751110

• Penicillin-induced immune hemolytic anemia. Occurrence of massive intravascular hemolysis.

  JAMA 19750804

• Relationship between the transport and toxicity of cephalosporins in the kidney.

  The Journal of infectious diseases 19750801

• Letter: Visual defect from chloroquine phosphate.

  Archives of dermatology 19750801

• Letter: Drug-induced red cell aplasia.

  British medical journal 19741019

• Acute Heinz-body anaemia in burned patients.

  Lancet (London, England) 19730901

• Probenecid-induced nephrotic syndrome.

  Archives of pathology 19720901

• Haematuria during methicillin therapy.

  Postgraduate medical journal 19710701

• Complications in a patient with subacute bacterial endocarditis with particular reference to massive penicillin therapy.

  The Medical journal of Australia 19690621

• Probenecid and renal failure.

  British medical journal 19680907

• Penicillin-induced haemolytic anaemia.

  British medical journal 19680907

• Probenecid, nephrotic syndrome, and renal failure.

  Annals of the rheumatic diseases 19680501

• Neurotoxicity and 'massive' intravenous therapy with penicillin. A study of possible predisposing factors.

  Archives of internal medicine 19670701

• Nephrotic syndrome caused by probenecid.

  JAMA 19670102