5735-53-5 | 3,4-Dihydro-2h-1,4-benzoxazine

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$7.00	$5.00
5g	98%	in stock	$19.00	$14.00
10g	98%	in stock	$31.00	$22.00
25g	98%	in stock	$74.00	$52.00

Description

• Catalog Number: AB63719
• Chemical Name: 3,4-Dihydro-2h-1,4-benzoxazine
• CAS Number: 5735-53-5
• Molecular Formula: C8H9NO
• Molecular Weight: 135.1632
• MDL Number: MFCD02181098
• SMILES: C1CNc2c(O1)cccc2

Computed Properties

• Complexity: 116
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Undefined Atom Stereocenter Count: 1
• XLogP3: 1.7

Literature

• Fluorinated dual antithrombotic compounds based on 1,4-benzoxazine scaffold.

  European journal of medicinal chemistry 20120401

• Regioselective synthesis of heterocycles containing nitrogen neighboring an aromatic ring by reductive ring expansion using diisobutylaluminum hydride and studies on the reaction mechanism.

  The Journal of organic chemistry 20100205

• 3,4-Dihydro-2H-1,4-benzoxazine derivatives combining thrombin inhibitory and glycoprotein IIb/IIIa receptor antagonistic activity as a novel class of antithrombotic compounds with dual function.

  Journal of medicinal chemistry 20080925

• Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines.

  Bioorganic & medicinal chemistry letters 20080815

• Novel 2,3-dihydro-1,4-benzoxazines as potent and orally bioavailable inhibitors of tumor-driven angiogenesis.

  Journal of medicinal chemistry 20080327

• 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists.

  Bioorganic & medicinal chemistry letters 20070615

• A new synthesis of 2,3-dihydrobenzo[1,4]dioxine and 3,4-dihydro-2H-benzo[1,4]oxazine derivatives by tandem palladium-catalyzed oxidative aminocarbonylation-cyclization of 2-prop-2-ynyloxyphenols and 2-prop-2-ynyloxyanilines.

  The Journal of organic chemistry 20060929

• Development of 3,4-dihydro-2H-benzo[1,4]oxazine derivatives as dual thromboxane A2 receptor antagonists and prostacyclin receptor agonists.

  Bioorganic & medicinal chemistry 20060315

• Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity.

  Bioorganic & medicinal chemistry letters 20060301

• Generation of arylnitrenium ions by nitro-reduction and gas-phase synthesis of N-heterocycles.

  Journal of the American Society for Mass Spectrometry 20041101

• (Z)-7-Chloro-3-[(3-chlorophenyl)-methylidene]-4-p-tosyl-3,4-dihydro-2H-1,4-benzoxazine.

  Acta crystallographica. Section C, Crystal structure communications 20010601