5747-48-8 | 11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine

Packsize	Purity	Availability	Price	Discounted Price
10mg	95%	in stock	$99.00	$70.00
100mg	95%	in stock	$102.00	$71.00
250mg	95%	in stock	$170.00	$119.00
1g	95%	in stock	$432.00	$302.00
5g	95%	in stock	$1,435.00	$1,004.00

Description

• Catalog Number: AG69782
• Chemical Name: 11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine
• CAS Number: 5747-48-8
• Molecular Formula: C17H17N3S
• Molecular Weight: 295.402
• MDL Number: MFCD09835366
• SMILES: N1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2

Computed Properties

• Complexity: 392
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 2.5

Literature

• Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders.

  Frontiers in psychiatry 20130101

• Metabolism of the active metabolite of quetiapine, N-desalkylquetiapine in vitro.

  Drug metabolism and disposition: the biological fate of chemicals 20120901

• Identification and characterization of potential impurities of quetiapine fumarate.

  Pharmaceutical development and technology 20090101

• N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080901

• Antipsychotic and antidepressive effects of second generation antipsychotics: two different pharmacological mechanisms?

  European archives of psychiatry and clinical neuroscience 20050601