577779-57-8 | 4,5,6,7-Tetrabromobenzimidazole

Packsize	Purity	Availability	Price	Discounted Price
10mg	98%	in stock	$102.00	$72.00
25mg	98%	in stock	$242.00	$170.00
50mg	98%	in stock	$407.00	$285.00

Description

• Catalog Number: AG68055
• Chemical Name: 4,5,6,7-Tetrabromobenzimidazole
• CAS Number: 577779-57-8
• Molecular Formula: C7H2Br4N2
• Molecular Weight: 433.7202
• MDL Number: MFCD04116202
• SMILES: Brc1c(Br)c(Br)c2c(c1Br)[nH]cn2

Computed Properties

• Complexity: 203
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• XLogP3: 4.3

Literature

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  Organic & biomolecular chemistry 20121121

• Modified tetrahalogenated benzimidazoles with CK2 inhibitory activity are active against human prostate cancer cells LNCaP in vitro.

  Bioorganic & medicinal chemistry 20120715

• CK2α and CK2α' subunits differ in their sensitivity to 4,5,6,7-tetrabromo- and 4,5,6,7-tetraiodo-1H-benzimidazole derivatives.

  European journal of medicinal chemistry 20120101

• HMGA1 is a novel downstream nuclear target of the insulin receptor signaling pathway.

  Scientific reports 20120101

• GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis.

  Nature chemical biology 20111201

• Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of EEF1D as a substrate for CK2.

  Journal of proteome research 20111104

• Design and synthesis of CK2 inhibitors.

  Molecular and cellular biochemistry 20111001

• Protein kinase CK2 increases glutamatergic input in the hypothalamus and sympathetic vasomotor tone in hypertension.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110601

• Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors.

  Neuron 20100923

• Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.

  PLoS genetics 20100701

• Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro.

  Cell and tissue research 20100501

• Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2.

  The Journal of biological chemistry 20100409

• Halogenated imidazole derivatives block RNA polymerase II elongation along mitogen inducible genes.

  BMC molecular biology 20100101

• Synthesis and proapoptotic properties of new casein kinase II inhibitors.

  Acta poloniae pharmaceutica 20100101

• Efficacy and mechanism of anti-tumor action of new potential CK2 inhibitors toward glioblastoma cells.

  International journal of oncology 20091101

• Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2.

  Bioorganic & medicinal chemistry 20091015

• Exploring the binding of inhibitors derived from tetrabromobenzimidazole to the CK2 protein using a QM/MM-PB/SA approach.

  Journal of chemical information and modeling 20090401

• Synthesis of new analogs of benzotriazole, benzimidazole and phthalimide--potential inhibitors of human protein kinase CK2.

  Bioorganic & medicinal chemistry 20090215

• The selectivity of inhibitors of protein kinase CK2: an update.

  The Biochemical journal 20081101

• New inhibitors of protein kinase CK2, analogues of benzimidazole and benzotriazole.

  Molecular and cellular biochemistry 20080901

• Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage.

  EMBO reports 20080801

• An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets.

  Molecular & cellular proteomics : MCP 20080601

• Ecto-phosphorylation of CD98 regulates cell-cell interactions.

  PloS one 20080101

• The ATP-binding site of protein kinase CK2 holds a positive electrostatic area and conserved water molecules.

  Chembiochem : a European journal of chemical biology 20071015

• Treatment of P190 Bcr/Abl lymphoblastic leukemia cells with inhibitors of the serine/threonine kinase CK2.

  Leukemia 20070101

• Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2.

  Biochimica et biophysica acta 20051230

• Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.

  Chemistry & biology 20051101

• Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.

  Journal of medicinal chemistry 20041202

• TBBz but not TBBt discriminates between two molecular forms of CK2 in vivo and its implications.

  Biochemical and biophysical research communications 20031219

• Polyhalogenobenzimidazoles: synthesis and their inhibitory activity against casein kinases.

  Bioorganic & medicinal chemistry 20030901

• Alternative binding modes of an inhibitor to two different kinases.

  European journal of biochemistry 20030801

• Selectivity of 4,5,6,7-tetrabromobenzimidazole as an ATP-competitive potent inhibitor of protein kinase CK2 from various sources.

  Biochemical and biophysical research communications 20030620

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419