583-08-4 | Nicotinoyl-glycine

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$42.00	$30.00
5g	>98.0%(T)	in stock	$108.00	$75.00
25g	95%	in stock	$315.00	$221.00

Description

• Catalog Number: AB59349
• Chemical Name: Nicotinoyl-glycine
• CAS Number: 583-08-4
• Molecular Formula: C8H8N2O3
• Molecular Weight: 180.1607
• MDL Number: MFCD00023578
• SMILES: OC(=O)CNC(=O)c1cccnc1
• NSC Number: 71273

Computed Properties

• Complexity: 206
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: -0.4

Literature

• Simultaneous quantification of niacin and its three main metabolites in human plasma by LC-MS/MS.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901

• Beneficial metabolic effects of 2',3',5'-tri-acetyl-N6- (3-hydroxylaniline) adenosine in the liver and plasma of hyperlipidemic hamsters.

  PloS one 20120101

• Assessment of potential pharmacokinetic interactions of ezetimibe/simvastatin and extended-release niacin tablets in healthy subjects.

  European journal of clinical pharmacology 20110501

• Feedback modeling of non-esterified fatty acids in rats after nicotinic acid infusions.

  Journal of pharmacokinetics and pharmacodynamics 20110201

• Pharmacokinetics and dose recommendations of Niaspan® in chronic kidney disease and dialysis patients.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110101

• Chemometric analysis of biofluids from mice experimentally infected with Schistosoma mansoni.

  Parasites & vectors 20110101

• [Determination of nicacid and its metabolites in human plasma by HPLC-MS/MS].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20101101

• Simultaneous determination of niacin and its metabolites--nicotinamide, nicotinuric acid and N-methyl-2-pyridone-5-carboxamide--in human plasma by LC-MS/MS and its application to a human pharmacokinetic study.

  Biomedical chromatography : BMC 20101001

• Role of nicotinamide in DNA damage, mutagenesis, and DNA repair.

  Journal of nucleic acids 20100101

• A comparison of the pharmacokinetics of two different formulations of extended-release niacin.

  Current medical research and opinion 20090101

• Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).

  Bioorganic & medicinal chemistry 20081201

• Targeting multiple dyslipidemias with fixed combinations--focus on extended release niacin and simvastatin.

  Vascular health and risk management 20081001

• Analysis of time-related metabolic fluctuations induced by ethionine in the rat.

  Journal of proteome research 20071201

• The comparative bioavailability of an extended-release niacin and lovastatin fixed dose combination tablet versus extended-release niacin tablet, lovastatin tablet and a combination of extended-release niacin tablet and lovastatin tablet.

  Biopharmaceutics & drug disposition 20070901

• Plasma and urine pharmacokinetics of niacin and its metabolites from an extended-release niacin formulation.

  International journal of clinical pharmacology and therapeutics 20070801

• Nicotinic acid induces secretion of prostaglandin D2 in human macrophages: an in vitro model of the niacin flush.

  Atherosclerosis 20070601

• Effect of the rate of niacin administration on the plasma and urine pharmacokinetics of niacin and its metabolites.

  Journal of clinical pharmacology 20070601

• Azabicyclic amino acids by stereoselective dearomatizing cyclization of the enolates of N-nicotinoyl glycine derivatives.

  Organic letters 20061109

• Simultaneous determination of niacin, niacinamide and nicotinuric acid in human plasma.

  Journal of pharmaceutical and biomedical analysis 20050104

• Simultaneous determination of nicotinic acid and its metabolites using hydrophilic interaction chromatography with tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20050101

• Effects of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinuric acid by rats.

  Bioscience, biotechnology, and biochemistry 20040101

• Synthesis and asymmetric reducing performance of chitin/dihydronicotinamide conjugates having glycine or L-leucine spacer arms.

  Biomacromolecules 20020101