5875-06-9 | Proparacaine, HCl

Packsize	Purity	Availability	Price	Discounted Price
1mg	98+%	in stock	$7.00	$5.00
25mg	98+%	in stock	$9.00	$6.00
100mg	98+%	in stock	$16.00	$11.00
250mg	98+%	in stock	$28.00	$19.00
1g	98+%	in stock	$60.00	$42.00
5g	98+%	in stock	$209.00	$146.00

Description

• Catalog Number: AI53147
• Chemical Name: Proparacaine, HCl
• CAS Number: 5875-06-9
• Molecular Formula: C16H27ClN2O3
• Molecular Weight: 330.8502
• MDL Number: MFCD00083467
• SMILES: CCCOc1ccc(cc1N)C(=O)OCCN(CC)CC.Cl
• NSC Number: 759896

Computed Properties

• Complexity: 295
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 22
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 10

Literature

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  International ophthalmology 20120601

• Factors affecting patients' pain intensity during in office intravitreal injection procedure.

  Retina (Philadelphia, Pa.) 20120401

• Randomized double-masked controlled trial comparing pain scores with and without the use of supplementary 2% lidocaine gel in LASIK.

  American journal of ophthalmology 20120401

• Comparison of topical anesthetics for intravitreal injections : a randomized clinical trial.

  Retina (Philadelphia, Pa.) 20120401

• Ophthalmomyiasis externa caused by Muscae fly larva in deserts of the Thar.

  Ocular immunology and inflammation 20120401

• Local anaesthetic eye drops for prevention of pain in preterm infants undergoing screening for retinopathy of prematurity.

  The Cochrane database of systematic reviews 20110907

• The in vitro effects of proxymetacaine, fluorescein, and fusidic acid on real-time PCR assays used for the diagnosis of Feline herpesvirus 1 and Chlamydophila felis infections.

  Veterinary ophthalmology 20110901

• Pain relief for premature infants during ophthalmology assessment.

  Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 20110601

• Effect of a proparacaine 0.50%-sodium fluorescein 0.25% mix and contact ultrasound pachymetry on central and midperipheral corneal thickness measured by noncontact optical pachymetry.

  Journal of cataract and refractive surgery 20110501

• Topical anesthetic abuse keratopathy: a commonly overlooked health care problem.

  Cornea 20110501

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• No-patch 23-gauge vitrectomy under topical anesthesia: a pilot study.

  Indian journal of ophthalmology 20110101

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  International ophthalmology 20101201

• Effect of topical anesthesia and age on pain scores during retinopathy of prematurity screening.

  Journal of perinatology : official journal of the California Perinatal Association 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Dilute proparacaine for the management of acute corneal injuries in the emergency department.

  CJEM 20100901

• The reuse of ophthalmic minims: an unacceptable cross-infection risk?

  Eye (London, England) 20100801

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• The systemic toxicity of equipotent proxymetacaine, oxybuprocaine, and bupivacaine during continuous intravenous infusion in rats.

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  Journal of the Formosan Medical Association = Taiwan yi zhi 20091201

• Proparacaine complexation with beta-cyclodextrin and p-sulfonic acid calix[6]arene, as evaluated by varied (1)H-NMR approaches.

  Magnetic resonance in chemistry : MRC 20090901

• Topical proparacaine and episcleral venous pressure in the rabbit.

  Investigative ophthalmology & visual science 20090601

• Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats.

  Neuroscience letters 20090501

• Prolonged corneal anaesthesia by proxymetacaine hydrochloride detected by a thermal cooling stimulus.

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• Liquid nitrogen cryotherapy of superior limbic keratoconjunctivitis.

  American journal of ophthalmology 20090201

• Antibacterial activity of preservative-free topical anesthetic drops in current use in ophthalmology departments.

  Cornea 20090101

• An atypical presentation of acanthamoeba keratitis in a patient with keratoconus treated briefly with topical anesthetic.

  Eye & contact lens 20090101

• Comparative study of analgesic effectiveness using three different anesthetic techniques for intravitreal injection of bevacizumab.

  Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20090101

• Adjustable suture strabismus surgery in infants and children.

  Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 20081201

• Evaluation of duration of corneal anesthesia induced with ophthalmic 0.5% proparacaine hydrochloride by use of a Cochet-Bonnet aesthesiometer in clinically normal horses.

  American journal of veterinary research 20081201

• Neuroprotective effect of intravitreal triamcinolone acetonide against photoreceptor apoptosis in a rabbit model of subretinal hemorrhage.

  Investigative ophthalmology & visual science 20080901

• Topology of a ternary complex (proparacaine-beta-cyclodextrin-liposome) by STD NMR.

  Magnetic resonance in chemistry : MRC 20080901

• A lacrimal sac abscess incision and drainage technique.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20080901

• Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway.

  Diabetes 20080801

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  Ophthalmology 20080801

• Patient comfort and surgeon satisfaction during cataract surgery using topical anesthesia with or without dexmedetomidine sedation.

  European journal of ophthalmology 20080101

• Anterior sub-Tenon's anesthesia for the treatment of retinopathy of prematurity.

  Journal of pediatric ophthalmology and strabismus 20080101

• Intraoperative adjustable suture strabismus surgery under topical and subconjunctival anesthesia.

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  Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20071201

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  The Cochrane database of systematic reviews 20070718

• Analgesic efficacy of single-dose parecoxib for corneal suturing in children.

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• Posterior vitrectomy under topical anesthesia.

  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20070401

• Assisted local anaesthesia for endoscopic dacryocystorhinostomy.

  Clinical & experimental ophthalmology 20070401

• An assessment of the discomfort associated with the use of rose bengal 1% eyedrops on the normal human eye: a comparison with saline 0.9% and a topical ocular anaesthetic.

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• Topical anesthesia in transconjunctival sutureless 25-gauge vitrectomy for macular-based disorders.

  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20070101

• Effect of proparacaine on central corneal thickness values: an evaluation using noncontact specular microscopy and pentacam.

  Cornea 20070101

• Assessment of bacterial contamination of three multidose ophthalmic solutions.

  Veterinary ophthalmology 20070101

• Phacoemulsification in vitrectomized eyes under topical anesthesia.

  European journal of ophthalmology 20070101

• Duration of corneal anesthesia following topical administration of 0.5% proparacaine hydrochloride solution in clinically normal cats.

  American journal of veterinary research 20061001

• Prospective randomized double-masked trial to evaluate perioperative pain profile in different stages of simultaneous bilateral LASIK.

  Cornea 20060901

• Pupil dilation using a pledget sponge: a randomized controlled trial.

  Clinical & experimental ophthalmology 20060801

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  The Cochrane database of systematic reviews 20060719

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

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• Contamination of single-use Minims eye drops by multiple use in clinics.

  The Journal of hospital infection 20060201

• Comparison of corneal thickness after the instillation of topical anesthetics: proparacaine versus oxybuprocaine.

  Cornea 20060101

• Anaesthetic abuse keratopathy as a manifestation of ocular Munchausen's syndrome.

  Clinical & experimental ophthalmology 20060101

• Subtenon lidocaine vs topical proparacaine in adult strabismus surgery.

  Annals of ophthalmology (Skokie, Ill.) 20060101

• Patient pain during stretching of small pupils in phacoemulsification performed using topical anesthesia.

  Journal of cataract and refractive surgery 20050901

• Efficacy of sucrose to reduce pain in premature infants during eye examinations for retinopathy of prematurity.

  The Annals of pharmacotherapy 20050601

• Efficacy of topical anesthetics to reduce pain in premature infants during eye examinations for retinopathy of prematurity.

  The Annals of pharmacotherapy 20050501

• Flap suturing with proparacaine for recurrent epithelial ingrowth following laser in situ keratomileusis surgery.

  Journal of cataract and refractive surgery 20050501

• Randomised controlled trial of sub-Tenon's block versus topical anaesthesia for cataract surgery: a comparison of patient satisfaction.

  The British journal of ophthalmology 20050301

• Duration of effect and effect of multiple doses of topical ophthalmic 0.5% proparacaine hydrochloride in clinically normal dogs.

  American journal of veterinary research 20050101

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  Vestnik oftalmologii 20050101

• Systemic manifestations in response to mydriasis and physical examination during screening for retinopathy of prematurity.

  Retina (Philadelphia, Pa.) 20040401

• Effect of midazolam on anxiety level and pain perception in cataract surgery with topical anesthesia.

  Journal of cataract and refractive surgery 20040201

• Epithelial activity of hexokinase and glucose-6-phosphate dehydrogenase in cultured bovine lenses recovering from pharmaceutical-induced optical damage.

  Molecular vision 20031103

• Survival of equine herpesvirus-4, feline herpesvirus-1, and feline calicivirus in multidose ophthalmic solutions.

  Veterinary ophthalmology 20021201

• In vivo transscleral iontophoresis of amikacin to rabbit eyes.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20021201

• Surgeon experience and patient comfort during clear corneal phacoemulsification under topical local anesthesia.

  Journal of cataract and refractive surgery 20021101

• The local anesthetic proparacaine modifies sodium transport in toad skin and perturbs the structures of model and cell membranes.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101

• Allergic contact dermatitis to proparacaine with subsequent cross-sensitization to tetracaine from ophthalmic preparations.

  American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 20010901

• The efficacy of 0.5% proparacaine stored at room temperature.

  Veterinary ophthalmology 20010901

• A comparative study of proxymetacaine-fluorescein and lignocaine-fluorescein use during applanation tonometry.

  The British journal of ophthalmology 20010401

• Does instilling proxymetacaine before cyclopentolate significantly reduce stinging? The implications of paediatric cycloplegia.

  The British journal of ophthalmology 20010201

• Local anaesthesia for vitreoretinal surgery: an audit of patient and surgical experience.

  European journal of ophthalmology 20010101

• Inhibition of pilocarpine-induced aqueous humor flare, hypotony, and miosis by topical administration of anti-inflammatory and anesthetic drugs to dogs.

  American journal of veterinary research 19980401