59-30-3 | Folic Acid

Packsize	Purity	Availability	Price	Discounted Price
25g	98%	in stock	$12.00	$8.00
100g	98%	in stock	$43.00	$30.00
500g	98%	in stock	$142.00	$99.00

Description

• Catalog Number: AB46189
• Chemical Name: Folic Acid
• CAS Number: 59-30-3
• Molecular Formula: C19H19N7O6
• Molecular Weight: 441.3975
• MDL Number: MFCD08273745
• SMILES: OC(=O)CC[C@@H](C(=O)O)NC(=O)c1ccc(cc1)NCc1cnc2c(n1)c(=O)[nH]c(n2)N
• NSC Number: 758158

Computed Properties

• Complexity: 767
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 32
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 6
• Rotatable Bond Count: 9
• XLogP3: -1.1

Upstream Synthesis Route

Folic acid, also known as vitamin B9, plays a crucial role in various chemical synthesis processes. In the realm of organic chemistry, folic acid is widely applied as a key component in the synthesis of nucleic acids, such as DNA and RNA. Its participation in one-carbon transfer reactions makes it an essential cofactor in the biosynthesis of purines and pyrimidines, the building blocks of DNA and RNA.Furthermore, folic acid is employed in the synthesis of amino acids, specifically methionine, by contributing methyl groups for the methylation of homocysteine. This process is vital for protein synthesis and various metabolic pathways in living organisms. The ability of folic acid to donate and shuttle one-carbon units makes it a versatile and indispensable molecule in the realm of chemical synthesis.In pharmaceutical chemistry, folic acid serves as a precursor for the synthesis of various antifolate drugs, including methotrexate and trimethoprim. These drugs function by inhibiting the enzyme dihydrofolate reductase, disrupting folate metabolism in cancer cells and bacteria, respectively. The incorporation of folic acid derivatives in drug design exemplifies its significance in medicinal chemistry and the development of therapeutic agents.Beyond its role in nucleic acid and amino acid synthesis, folic acid also finds applications in the preparation of folate conjugates for targeted drug delivery systems and in the design of novel catalysts for organic transformations. Its versatility and importance in diverse chemical processes highlight the profound impact of folic acid in advancing the field of chemical synthesis.