59147-84-1 | 2-((2-Hydroxyethyl)thio)-3-methylnaphthalene-1,4-dione

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	2 weeks	$49.00	$35.00

Description

• Catalog Number: AG72532
• Chemical Name: 2-((2-Hydroxyethyl)thio)-3-methylnaphthalene-1,4-dione
• CAS Number: 59147-84-1
• Molecular Formula: C13H12O3S
• Molecular Weight: 248.2976
• MDL Number: MFCD11100314
• SMILES: OCCSC1=C(C)C(=O)c2c(C1=O)cccc2
• NSC Number: 672121

Computed Properties

• Complexity: 373
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• XLogP3: 1.4

Literature

• Formyl peptide receptor 1 and 2 dual agonist inhibits human neutrophil chemotaxis by the induction of chemoattractant receptor cross-desensitization.

  Journal of pharmacological sciences 20110101

• Grb2-associated binder-1 plays a central role in the hepatocyte growth factor enhancement of hepatoma growth inhibition by K vitamin analog compound 5.

  Hepatology (Baltimore, Md.) 20071201

• Phosphorylation regulates Myc expression via prolonged activation of the mitogen-activated protein kinase pathway.

  Journal of cellular physiology 20060701

• Modulation of bcl-2 family proteins in MAPK independent apoptosis induced by a cdc25 phosphatase inhibitor Cpd 5 in renal cancer cells.

  Oncology reports 20050901

• Vitamin K analog (compound 5) induces apoptosis in human hepatocellular carcinoma independent of the caspase pathway.

  Anti-cancer drugs 20050901

• Hepatocyte growth factor enhances protein phosphatase Cdc25A inhibitor compound 5-induced hepatoma cell growth inhibition via Akt-mediated MAPK pathway.

  Journal of cellular physiology 20050601

• Inhibition of rat liver regeneration after partial hepatectomy and induction of ERK phosphorylation by Cpd 5, a K vitamin-based anticancer compound.

  Carcinogenesis 20041201

• Involvement of c-Myc in growth inhibition of Hep 3B human hepatoma cells by a vitamin K analog.

  Journal of hepatology 20041101

• NAD(P)H:quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors.

  The Journal of pharmacology and experimental therapeutics 20040401

• Fluorouracil prodrugs for the treatment of proliferative vitreoretinopathy: formulation in silicone oil and in vitro release of fluorouracil.

  International journal of pharmaceutics 20030618

• Transient and sustained ERK phosphorylation and nuclear translocation in growth control.

  Journal of cellular physiology 20020801

• Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase.

  The Journal of biological chemistry 20020531

• EGFR-independent activation of ERK1/2 mediates growth inhibition by a PTPase antagonizing K-vitamin analog.

  Journal of cellular physiology 20020301

• Induction of apoptosis via mitogen-activated protein kinase pathway by a K vitamin analog in rat hepatocytes.

  Journal of hepatology 20020101

• Tumor cell growth inhibition and extracellular signal-regulated kinase (ERK) phosphorylation by novel K vitamins.

  Journal of molecular biology 20011207