59564-59-9 | 3,4-Dihydro-1h-quinoxalin-2-one

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$16.00	$12.00
5g	95%	in stock	$56.00	$39.00
25g	95%	in stock	$261.00	$183.00

Description

• Catalog Number: AG67057
• Chemical Name: 3,4-Dihydro-1h-quinoxalin-2-one
• CAS Number: 59564-59-9
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.1619
• MDL Number: MFCD00204133
• SMILES: O=C1CNc2c(N1)cccc2
• NSC Number: 73534

Computed Properties

• Complexity: 170
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Undefined Atom Stereocenter Count: 1
• XLogP3: 0.9

Upstream Synthesis Route

3,4-Dihydroquinoxalin-2(1H)-one, also known as DHQ, is a versatile compound widely used in chemical synthesis. It serves as a crucial building block in the preparation of various organic molecules due to its unique structural features and reactivity.In chemical synthesis, DHQ can be employed as a key intermediate for the production of diverse pharmaceuticals, agrochemicals, and functional materials. Its cyclic structure provides a stable framework for the introduction of additional functional groups through various synthetic transformations. By utilizing DHQ as a starting material, chemists can efficiently access complex molecular structures with tailored properties and desired functionalities.Moreover, DHQ is particularly valuable in the synthesis of heterocyclic compounds, which play a vital role in pharmaceutical drug discovery and development. Its ability to undergo selective reactions and form intricate ring systems makes it an indispensable tool in the construction of biologically active compounds with potential therapeutic applications.Overall, the application of 3,4-Dihydroquinoxalin-2(1H)-one in chemical synthesis enables researchers to explore new pathways for the creation of novel materials and molecules with significant implications in various industries.

Literature

• Aspartic acid scaffold in bradykinin B1 antagonists.

  Journal of peptide science : an official publication of the European Peptide Society 20090601

• Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors.

  Bioorganic & medicinal chemistry letters 20090201

• Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists.

  Bioorganic & medicinal chemistry letters 20080815

• Binding modes of dihydroquinoxalinones in a homology model of bradykinin receptor 1.

  Biochemical and biophysical research communications 20050527

• Discovery of a potent, non-peptide bradykinin B1 receptor antagonist.

  Journal of the American Chemical Society 20030625

• Traceless, self-cleaving solid- and solution-phase parallel synthesis of 3,4,7-trisubstituted 3,4-dihydroquinoxalin-2-ones.

  Journal of combinatorial chemistry 20010101