598-41-4 | Glycinamide

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$66.00	$47.00
5g	≥95%	in stock	$103.00	$72.00

Description

• Catalog Number: AG64803
• Chemical Name: Glycinamide
• CAS Number: 598-41-4
• Molecular Formula: C2H6N2O
• Molecular Weight: 74.0818
• MDL Number: MFCD01859715
• SMILES: NCC(=O)N

Computed Properties

• Complexity: 42.9
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 5
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: -1.8

Literature

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  Bioorganic & medicinal chemistry 20031001

• 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.

  Bioorganic & medicinal chemistry 20031001

• Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.

  Bioorganic & medicinal chemistry 20031001

• On the structural and functional modularity of glycinamide ribonucleotide formyltransferases.

  Protein science : a publication of the Protein Society 20031001

• Tomoregulin ectodomain shedding by proinflammatory cytokines.

  Life sciences 20030815

• Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells.

  International journal of oncology 20030801

• The role of Pemetrexed (Alimta , LY231514) in lung cancer therapy.

  Clinical lung cancer 20030701

• Pemetrexed and its emerging role in the treatment of thoracic malignancies.

  Expert opinion on investigational drugs 20030501

• Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.

  Biochemical pharmacology 20030401

• Pemetrexed (Alimta): a promising new agent for the treatment of breast cancer.

  Seminars in oncology 20030401

• Pemetrexed (Alimta): a novel multitargeted antifolate agent.

  Expert review of anticancer therapy 20030401

• Metal-catalyzed hydroxylaminolysis of unactivated amide and peptide bonds.

  Organic & biomolecular chemistry 20030307

• Novel antifolate drugs.

  Current oncology reports 20030301

• Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.

  International journal of cancer 20030220

• Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene and derived amino acid amides.

  Journal of medicinal chemistry 20030213

• Fragmentation reactions of protonated peptides containing glutamine or glutamic acid.

  Journal of mass spectrometry : JMS 20030201

• Deaza analogs of folic acid as antitumor agents.

  Current pharmaceutical design 20030101

• Practical asymmetric synthesis of vicinal diamines through the catalytic highly enantioselective alkylation of glycine amide derivatives.

  Angewandte Chemie (International ed. in English) 20030101

• Current data with pemetrexed (Alimta) in non-small-cell lung cancer.

  Clinical lung cancer 20030101

• LY309887, antifolate via the folate receptor suppresses murine type II collagen-induced arthritis.

  Clinical and experimental rheumatology 20030101

• Biochemical and structural characterization of the cross-linked complex of nitrogenase: comparison to the ADP-AlF4(-)-stabilized structure.

  Biochemistry 20021231

• Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.

  Biochemistry 20021203

• Molecular, biochemical, and cellular pharmacology of pemetrexed.

  Seminars in oncology 20021201

• Pemetrexed safety and dosing strategy.

  Seminars in oncology 20021201

• Preclinical and clinical studies with combinations of pemetrexed and gemcitabine.

  Seminars in oncology 20021201

• Pemetrexed in pancreatic cancer.

  Seminars in oncology 20021201

• Pemetrexed: an active new agent for breast cancer.

  Seminars in oncology 20021201

• A universal, vector-based system for nucleic acid reading-frame selection.

  Protein engineering 20021201

• Alimta (pemetrexed disodium): a multitargeted antifolate for the treatment of mesothelioma.

  Lung cancer (Amsterdam, Netherlands) 20021101

• New 2H-tetrahydro-1, 3, 5-thiadiazine-2-thiones incorporating glycine and glycinamide as potential antifungal agents.

  Archiv der Pharmazie 20021101

• Chemotactic agents induce IL-6Ralpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type.

  European journal of immunology 20021001

• Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163.

  Journal of leukocyte biology 20021001

• Chemically modified 'polar patch' mutants of subtilisin in peptide synthesis with remarkably broad substrate acceptance: designing combinatorial biocatalysts.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20020916

• Antifolates targeting purine synthesis allow entry of tumor cells into S phase regardless of p53 function.

  Cancer research 20020915

• The pemetrexed/gemcitabine combination in pancreatic cancer.

  Cancer 20020815

• 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.

  Bioorganic & medicinal chemistry 20020801

• Pemetrexed disodium combined with oxaliplatin, SN38, or 5-fluorouracil, based on the quantitation of drug interactions in human HT29 colon cancer cells.

  International journal of oncology 20020801

• Effect of short-term N(2) deficiency on expression of the ureide pathway in cowpea root nodules.

  Plant physiology 20020701

• [Differentially expressed genes in vascular endothelial cell line ECV 304 induced by high density lipoprotein].

  Zhonghua yi xue za zhi 20020701

• PurT-encoded glycinamide ribonucleotide transformylase. Accommodation of adenosine nucleotide analogs within the active site.

  The Journal of biological chemistry 20020628

• New N(3)S donor ligand small peptide analogues of the N-mercaptoacetyl-glycylglycylglycine ligand in the clinically used Tc-99m renal imaging agent: evidence for unusual amide oxygen coordination by two new ligands.

  Inorganic chemistry 20020603

• Incorporation of pemetrexed (Alimta) into the treatment of non-small cell lung cancer (thoracic tumors).

  Seminars in oncology 20020601

• Pemetrexed: translational research in breast cancer.

  Seminars in oncology 20020601

• Pemetrexed: a promising new treatment for breast cancer.

  Seminars in oncology 20020401

• Pemetrexed in the treatment of selected solid tumors.

  Seminars in oncology 20020401

• Nonpeptide alpha(v)beta(3) antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide.

  Bioorganic & medicinal chemistry letters 20020107

• Synthesis of a new antischistosomally active and toxicologically tolerant C-12 monothione surrogate of the universal antihelmintic praziquantel.

  Acta poloniae pharmaceutica 20020101

• Gemcitabine and pemetrexed disodium combinations in vitro and in vivo.

  Lung cancer (Amsterdam, Netherlands) 20011201

• Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.

  Biochemistry 20011113

• Proton transfer dynamics of GART: the pH-dependent catalytic mechanism examined by electrostatic calculations.

  Protein science : a publication of the Protein Society 20011101

• Pemetrexed disodium (Eli Lilly).

  Current opinion in investigational drugs (London, England : 2000) 20011101

• Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck.

  British journal of cancer 20010901

• Site-directed mutagenesis of ATP binding residues of biotin carboxylase. Insight into the mechanism of catalysis.

  The Journal of biological chemistry 20010706

• Synthesis and biological activity of 7-oxo substituted analogues of 5-deaza-5,6,7,8-tetrahydrofolic acid (5-DATHF) and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF).

  Journal of medicinal chemistry 20010705

• Involvement of a transformylase enzyme in siderophore synthesis in Pseudomonas aeruginosa.

  Microbiology (Reading, England) 20010601

• A permissive role for tumor necrosis factor in vascular endothelial growth factor-induced vascular permeability.

  Blood 20010301

• Increased shedding of angiotensin-converting enzyme by a mutation identified in the stalk region.

  The Journal of biological chemistry 20010223

• Gemcitabine and Pemetrexed disodium in treating breast cancer.

  Oncology (Williston Park, N.Y.) 20010201

• Synthetic Cu(II) and Ni(II) peptidases.

  Metal ions in biological systems 20010101

• Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors.

  The oncologist 20010101

• Preparation of Fab' from murine IgG2a for thiol reactive conjugation.

  Journal of drug targeting 20010101

• Sequence dependence of Alimta (LY231514, MTA) combined with doxorubicin in ZR-75-1 human breast carcinoma cells.

  Anticancer research 20010101