602306-29-6 | 2-​Pyrimidinamine, 4-​[2-​methyl-​1-​(1-​methylethyl)​-​1H-​imidazol-​5-​yl]​-​N-​[4-​(methylsulfonyl)​phenyl]​-

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$45.00	$31.00
5mg	98%	in stock	$54.00	$38.00
50mg	98%	in stock	$498.00	$348.00
100mg	98%	in stock	$742.00	$519.00

Description

• Catalog Number: AG68996
• Chemical Name: 2-​Pyrimidinamine, 4-​[2-​methyl-​1-​(1-​methylethyl)​-​1H-​imidazol-​5-​yl]​-​N-​[4-​(methylsulfonyl)​phenyl]​-
• CAS Number: 602306-29-6
• Molecular Formula: C18H21N5O2S
• Molecular Weight: 371.45663999999994
• MDL Number: MFCD11112135
• SMILES: CC(n1c(C)ncc1c1ccnc(n1)Nc1ccc(cc1)S(=O)(=O)C)C

Computed Properties

• Complexity: 556
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• XLogP3: 2.2

Literature

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  Molecular cancer therapeutics 20090701

• Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20081215

• The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing.

  Bioorganic & medicinal chemistry letters 20081215

• Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20081015

• Cyclin-dependent kinase pathways as targets for cancer treatment.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060410

• Cyclins and CDKS in development and cancer: lessons from genetically modified mice.

  Frontiers in bioscience : a journal and virtual library 20060101

• Mammalian cyclin-dependent kinases.

  Trends in biochemical sciences 20051101

• Cyclin D-dependent kinases, INK4 inhibitors and cancer.

  Biochimica et biophysica acta 20020314