60239-18-1 | DOTA

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$8.00	$5.00
1g	98%	in stock	$13.00	$9.00
5g	98%	in stock	$18.00	$12.00
10g	98%	in stock	$35.00	$24.00
25g	98%	in stock	$50.00	$35.00
100g	98%	in stock	$196.00	$137.00

Description

• Catalog Number: AG64437
• Chemical Name: DOTA
• CAS Number: 60239-18-1
• Molecular Formula: C16H28N4O8
• Molecular Weight: 404.4155
• MDL Number: MFCD00068657
• SMILES: OC(=O)CN1CCN(CCN(CCN(CC1)CC(=O)O)CC(=O)O)CC(=O)O
• NSC Number: 681107

Computed Properties

• Complexity: 447
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 12
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 8
• XLogP3: -10.6

Literature

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  Chemistry (Weinheim an der Bergstrasse, Germany) 20130610

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  Journal of medicinal chemistry 20130328

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• Measurement of protein synthesis: in vitro comparison of (68)Ga-DOTA-puromycin, [ (3)H]tyrosine, and 2-fluoro-[ (3)H]tyrosine.

  Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20130101

• Microfluidic radiolabeling of biomolecules with PET radiometals.

  Nuclear medicine and biology 20130101

• Gadolinium complexes of monophosphinic acid DOTA derivatives conjugated to cyclodextrin scaffolds: efficient MRI contrast agents for higher magnetic fields.

  Dalton transactions (Cambridge, England : 2003) 20121121

• The first structural and spectroscopic study of a paramagnetic 5f DO3A complex.

  Dalton transactions (Cambridge, England : 2003) 20121114

• Radiosynthesis of 68Ga-labelled DOTA-biocytin (68Ga-r-BHD) and assessment of its pharmaceutical quality for clinical use.

  Nuclear medicine communications 20121101

• 64Cu-p-NH2-Bn-DOTA-hu14.18K322A, a PET radiotracer targeting neuroblastoma and melanoma.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20121101

• Synthesis and in vivo pharmacokinetic evaluation of degradable shell cross-linked polymer nanoparticles with poly(carboxybetaine) versus poly(ethylene glycol) surface-grafted coatings.

  ACS nano 20121023

• Synthesis and biological evaluation of a novel (177)Lu-DOTA-[Gly(3)-cyclized(Dap(4), (d)-Phe(7), Asp(10))-Arg(11)]α-MSH(3-13) analogue for melanocortin-1 receptor-positive tumor targeting.

  Cancer biotherapy & radiopharmaceuticals 20121001

• Solid-supported NOTA and DOTA chelators useful for the synthesis of 3'-radiometalated oligonucleotides.

  Bioconjugate chemistry 20120919

• Synthesis and characterization of αvβ₃-targeting peptidomimetic chelate conjugates for PET and SPECT imaging.

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• Simplified NaCl based (68)Ga concentration and labeling procedure for rapid synthesis of (68)Ga radiopharmaceuticals in high radiochemical purity.

  Bioconjugate chemistry 20120815

• Influence of DOTA chelator position on biodistribution and targeting properties of (111)In-labeled synthetic anti-HER2 affibody molecules.

  Bioconjugate chemistry 20120815

• Structural analysis of isomeric europium(III) chelates of NB-DOTMA.

  Inorganic chemistry 20120806

• Site-specific DOTA/europium-labeling of recombinant human relaxin-3 for receptor-ligand interaction studies.

  Amino acids 20120801

• Cyclotron produced ⁴⁴gSc from natural calcium.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20120801

• Synthesis and characterization of a hypoxia-sensitive MRI probe.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20120727

• In vivo targeting of HER2-positive tumor using 2-helix affibody molecules.

  Amino acids 20120701

• DOTAGA-anhydride: a valuable building block for the preparation of DOTA-like chelating agents.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20120618

• Synthesis of PECAM-1-specific 64Cu PET imaging agent: evaluation of myocardial infarction caused by ischemia-reperfusion injury in mouse.

  Bioorganic & medicinal chemistry letters 20120615

• Preclinical evaluation of radiolabeled DOTA-derivatized cyclic minigastrin analogs for targeting cholecystokinin receptor expressing malignancies.

  Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20120601

• Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis.

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• Peptide receptor radionuclide therapy with somatostatin analogues in neuroendocrine tumors.

  Anti-cancer agents in medicinal chemistry 20120601

• Synthesis and characterization of folic acid modified water-soluble chitosan derivatives for folate-receptor-mediated targeting.

  Bioorganic & medicinal chemistry letters 20120515

• 68Ga-labeling and in vivo evaluation of a uPAR binding DOTA- and NODAGA-conjugated peptide for PET imaging of invasive cancers.

  Nuclear medicine and biology 20120501

• Potential of the gastric motility drug lorglumide in prostate cancer imaging.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120411

• Europium(III) DOTA-tetraamide complexes as redox-active MRI sensors.

  Journal of the American Chemical Society 20120404

• Evaluation of (111)In-labeled macrocyclic chelator-amino acid derivatives for cancer imaging.

  Nuclear medicine and biology 20120401

• Therapeutic efficacy and toxicity of 225Ac-labelled vs. 213Bi-labelled tumour-homing peptides in a preclinical mouse model of peritoneal carcinomatosis.

  European journal of nuclear medicine and molecular imaging 20120401

• Design, recombinant expression and convenient A-chain N-terminal europium-labelling of a fully active human relaxin-3 analogue.

  The FEBS journal 20120401

• Treatment with unlabeled mAb BR96 after radioimmunotherapy with 177Lu-DOTA-BR96 in a syngeneic rat colon carcinoma model.

  Cancer biotherapy & radiopharmaceuticals 20120401

• Comparative evaluation of synthetic anti-HER2 Affibody molecules site-specifically labelled with 111In using N-terminal DOTA, NOTA and NODAGA chelators in mice bearing prostate cancer xenografts.

  European journal of nuclear medicine and molecular imaging 20120301

• Novel gastrin receptor-directed contrast agents - potential in brain tumor magnetic resonance imaging.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20120301

• Targeted catalytic inactivation of angiotensin converting enzyme by lisinopril-coupled transition-metal chelates.

  Journal of the American Chemical Society 20120222

• Magnetic anisotropy in a dysprosium/DOTA single-molecule magnet: beyond simple magneto-structural correlations.

  Angewandte Chemie (International ed. in English) 20120213

• Influence of formulation variables on the biodistribution of multifunctional block copolymer micelles.

  Journal of controlled release : official journal of the Controlled Release Society 20120210

• Imaging prostate cancer lymph node metastases with a multimodality contrast agent.

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• A novel lily-of-the-valley fragrance contrast agent for magnetic resonance and fluorescence imaging of prostate cancer cells.

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• ⁶⁸Ga-labelled peptides for diagnosis of gastroenteropancreatic NET.

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• Radiolabelled peptides for oncological diagnosis.

  European journal of nuclear medicine and molecular imaging 20120201

• Preliminary evaluation of a microwave-assisted metal-labeling strategy for quantification of peptides via RPLC-ICP-MS and the method of standard additions.

  Talanta 20120115

• 17O NMR and density functional theory study of the dynamics of the carboxylate groups in DOTA complexes of lanthanides in aqueous solution.

  Inorganic chemistry 20120102

• Complexation of metal ions with TRAP (1,4,7-triazacyclononane phosphinic acid) ligands and 1,4,7-triazacyclononane-1,4,7-triacetic acid: phosphinate-containing ligands as unique chelators for trivalent gallium.

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• Imaging of insulinlike growth factor type 1 receptor in prostate cancer xenografts using the affibody molecule 111In-DOTA-ZIGF1R:4551.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20120101

• Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105: implications for visualizing cancer invasion.

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• Positively charged lanthanide complexes with cyclen-based ligands: synthesis, solid-state and solution structure, and fluoride interaction.

  Inorganic chemistry 20111219

• Stability assessment of different chelating moieties used for elemental labeling of bio-molecules.

  Metallomics : integrated biometal science 20111201

• Evaluation of 177Lu-DOTA-sst2 antagonist versus 177Lu-DOTA-sst2 agonist binding in human cancers in vitro.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20111201

• Effects of terbium chelate structure on dipicolinate ligation and the detection of Bacillus spores.

  Journal of inorganic biochemistry 20111201

• Design, synthesis, and functionalization of dimeric peptides targeting chemokine receptor CXCR4.

  Journal of medicinal chemistry 20111110

• Impact of bifunctional chelators on biological properties of 111In-labeled cyclic peptide RGD dimers.

  Amino acids 20111101

• 68Ga-DOTA-affibody molecule for in vivo assessment of HER2/neu expression with PET.

  European journal of nuclear medicine and molecular imaging 20111101

• Comparative biodistribution of imaging agents for in vivo molecular profiling of disseminated prostate cancer in mice bearing prostate cancer xenografts: focus on 111In- and 125I-labeled anti-HER2 humanized monoclonal trastuzumab and ABY-025 affibody.

  Nuclear medicine and biology 20111101

• The pH sensitivity of -NH exchange in LnDOTA-tetraamide complexes varies with amide substituent.

  Contrast media & molecular imaging 20111101

• Modular strategy for the construction of radiometalated antibodies for positron emission tomography based on inverse electron demand Diels-Alder click chemistry.

  Bioconjugate chemistry 20111019

• DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra.

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• Harnessing nature's insights: synthetic small molecules with peroxidase-mimicking DNAzyme properties.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20110919

• Properties, solution state behavior, and crystal structures of chelates of DOTMA.

  Inorganic chemistry 20110905

• Analysis of the conformational behavior and stability of the SAP and TSAP isomers of lanthanide(III) NB-DOTA-type chelates.

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• Towards the rational design of MRI contrast agents: δ-substitution of lanthanide(III) NB-DOTA-tetraamide chelates influences but does not control coordination geometry.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20110905

• Amphiphilic multiarm star block copolymer-based multifunctional unimolecular micelles for cancer targeted drug delivery and MR imaging.

  Biomaterials 20110901

• Evaluation of 64Cu-labeled bifunctional chelate-bombesin conjugates.

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  European journal of nuclear medicine and molecular imaging 20110801

• Long-term in vivo magnetic resonance imaging tracking of endothelial progenitor cells transplanted in rat ischemic limbs and their angiogenic potential.

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• Evaluation of CCK2 receptor binding ligands: the inheritance of Thomas Behr.

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• Cell assay using a two-photon-excited europium chelate.

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• Preparation and biological evaluation of (177)Lu conjugated PR81 for radioimmunotherapy of breast cancer.

  Nuclear medicine and biology 20110801

• Novel DOTA-neurotensin analogues for 111In scintigraphy and 68Ga PET imaging of neurotensin receptor-positive tumors.

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• Investigations into whole water, prototropic and amide proton exchange in lanthanide(III) DOTA-tetraamide chelates.

  Dalton transactions (Cambridge, England : 2003) 20110707

• Positron emission tomography imaging of CD105 expression during tumor angiogenesis.

  European journal of nuclear medicine and molecular imaging 20110701

• Lanthanide-based time-resolved luminescence immunoassays.

  Analytical and bioanalytical chemistry 20110701

• Preparation and evaluation of a radiogallium complex-conjugated bisphosphonate as a bone scintigraphy agent.

  Nuclear medicine and biology 20110701

• Influence of an aliphatic linker between DOTA and synthetic Z(HER2:342) Affibody molecule on targeting properties of the (111)In-labeled conjugate.

  Nuclear medicine and biology 20110701

• Targeted cleavage of HIV RRE RNA by Rev-coupled transition metal chelates.

  Journal of the American Chemical Society 20110629

• Towards translation of 212Pb as a clinical therapeutic; getting the lead in!

  Dalton transactions (Cambridge, England : 2003) 20110621

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• Monoclonal antibodies for copper-64 PET dosimetry and radioimmunotherapy.

  Cancer biology & therapy 20110615

• DOTA derivatives for site-specific biomolecule-modification via click chemistry: synthesis and comparison of reaction characteristics.

  Bioorganic & medicinal chemistry 20110615

• DNP by thermal mixing under optimized conditions yields >60,000-fold enhancement of 89Y NMR signal.

  Journal of the American Chemical Society 20110608

• Synthesis and physicochemical characterization of new squalenoyl amphiphilic gadolinium complexes as nanoparticle contrast agents.

  Organic & biomolecular chemistry 20110607

• The interaction of La(3+) complexes of DOTA/DTPA glycoconjugates with the RCA(120) lectin: a saturation transfer difference NMR spectroscopic study.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20110601

• Macrocyclic chelator assembled RGD multimers for tumor targeting.

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• Preclinical evaluation of a new bombesin analog for imaging of gastrin-releasing peptide receptors.

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• A smart magnetic resonance imaging contrast agent responsive to adenosine based on a DNA aptamer-conjugated gadolinium complex.

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• Lanthanide dota-like complexes containing a picolinate pendant: structural entry for the design of Ln(III)-based luminescent probes.

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• An iminodiacetic acid based lanthanide binding tag for paramagnetic exchange NMR spectroscopy.

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• Synthesis and in vivo evaluation of 201Tl(III)-DOTA complexes for applications in SPECT imaging.

  Nuclear medicine and biology 20110501

• Highly improved metabolic stability and pharmacokinetics of indium-111-DOTA-gastrin conjugates for targeting of the gastrin receptor.

  Journal of medicinal chemistry 20110428

• Site-specific conjugation of monodispersed DOTA-PEGn to a thiolated diabody reveals the effect of increasing peg size on kidney clearance and tumor uptake with improved 64-copper PET imaging.

  Bioconjugate chemistry 20110420

• Biodistribution and clearance of small molecule hapten chelates for pretargeted radioimmunotherapy.

  Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20110401

• Preliminary evaluation of (177)Lu-labeled knottin peptides for integrin receptor-targeted radionuclide therapy.

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• Synthesis of 68Ga-labeled DOTA-nitroimidazole derivatives and their feasibilities as hypoxia imaging PET tracers.

  Bioorganic & medicinal chemistry 20110401

• Ga(III) chelates of amphiphilic DOTA-based ligands: synthetic route and in vitro and in vivo studies.

  Nuclear medicine and biology 20110401

• Site-specific 68Ga-labeled Annexin A5 as a PET imaging agent for apoptosis.

  Nuclear medicine and biology 20110401

• Spacer effects on in vivo properties of DOTA-conjugated dimeric [Tyr3]octreotate peptides synthesized by a 'Cu(I)-click' and 'sulfo-click' ligation method.

  Chembiochem : a European journal of chemical biology 20110321

• Radiolabeled affibody-albumin bioconjugates for HER2-positive cancer targeting.

  Bioconjugate chemistry 20110316

• Europium(III) DOTA-derivatives having ketone donor pendant arms display dramatically slower water exchange.

  Inorganic chemistry 20110307

• A small MRI contrast agent library of gadolinium(III)-encapsulated supramolecular nanoparticles for improved relaxivity and sensitivity.

  Biomaterials 20110301

• Biological stability evaluation of the α2β1 receptor imaging agents: diamsar and DOTA conjugated DGEA peptide.

  Bioconjugate chemistry 20110216

• Synthesis and evaluation of new iRGD peptide analogs for tumor optical imaging.

  Bioorganic & medicinal chemistry letters 20110215

• Challenges in optimizing a prostate carcinoma binding peptide, identified through the phage display technology.

  Molecules (Basel, Switzerland) 20110214

• The cell labeling efficacy, cytotoxicity and relaxivity of copper-activated MRI/PET imaging contrast agents.

  Biomaterials 20110201

• Macrocyclic complexes of scandium radionuclides as precursors for diagnostic and therapeutic radiopharmaceuticals.

  Journal of inorganic biochemistry 20110201

• Influence of biological assay conditions on stability assessment of radiometal-labelled peptides exemplified using a 177Lu-DOTA-minigastrin derivative.

  Nuclear medicine and biology 20110201

• Engineering an antibody with picomolar affinity to DOTA chelates of multiple radionuclides for pretargeted radioimmunotherapy and imaging.

  Nuclear medicine and biology 20110201

• Gd-complexes of 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-1,4,7,10-tetraacetic acid (DOTA) conjugates of tranexamates as a new class of blood-pool magnetic resonance imaging contrast agents.

  Journal of medicinal chemistry 20110113

• Development of a potent DOTA-conjugated bombesin antagonist for targeting GRPr-positive tumours.

  European journal of nuclear medicine and molecular imaging 20110101

• Development of new folate-based PET radiotracers: preclinical evaluation of ⁶⁸Ga-DOTA-folate conjugates.

  European journal of nuclear medicine and molecular imaging 20110101

• Imaging cancer using PET--the effect of the bifunctional chelator on the biodistribution of a (64)Cu-labeled antibody.

  Nuclear medicine and biology 20110101

• In vivo testing of 177Lu-labelled anti-PSMA antibody as a new radioimmunotherapeutic agent against prostate cancer.

  In vivo (Athens, Greece) 20110101

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  Nanoscale research letters 20110101

• Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe.

  PloS one 20110101

• TmDOTA-tetraglycinate encapsulated liposomes as pH-sensitive LipoCEST agents.

  PloS one 20110101

• Positron emission tomography imaging of CD105 expression with a 64Cu-labeled monoclonal antibody: NOTA is superior to DOTA.

  PloS one 20110101

• Advances in drug design of radiometal-based imaging agents for bone disorders.

  International journal of molecular imaging 20110101

• Microfluidic labeling of biomolecules with radiometals for use in nuclear medicine.

  Lab on a chip 20101221

• Gallium(III) complexes of DOTA and DOTA-monoamide: kinetic and thermodynamic studies.

  Inorganic chemistry 20101206

• Polymeric micelles in anticancer therapy: targeting, imaging and triggered release.

  Pharmaceutical research 20101201

• Polyion complex micelle MRI contrast agents from poly(ethylene glycol)-b-poly(l-lysine) block copolymers having Gd-DOTA; preparations and their control of T(1)-relaxivities and blood circulation characteristics.

  Journal of controlled release : official journal of the Controlled Release Society 20101201

• TETA analogue containing one methylenephosphonate pendant arm: Lanthanide complexes and biological evaluation of its 153Sm and 166Ho complexes.

  European journal of medicinal chemistry 20101201

• Characterization of metal-labelled peptides by matrix-assisted laser desorption/ionization mass spectrometry and tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20101130

• First bodipy-DOTA derivatives as probes for bimodal imaging.

  Chemical communications (Cambridge, England) 20101121

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  Biomaterials 20101101

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  Bioorganic & medicinal chemistry 20101101

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  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20101101

• Comparison of the stability of Y-90-, Lu-177- and Ga-68- labeled human serum albumin microspheres (DOTA-HSAM).

  Nuclear medicine and biology 20101101

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  Nuclear medicine and biology 20101101

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  European journal of nuclear medicine and molecular imaging 20101001

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  Journal of medicinal chemistry 20100923

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  Bioorganic & medicinal chemistry letters 20100915

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  Bioorganic & medicinal chemistry letters 20100815

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  Chemical communications (Cambridge, England) 20100814

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  European journal of nuclear medicine and molecular imaging 20100801

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  Metallomics : integrated biometal science 20100801

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  Nanotechnology 20100723

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  Bioconjugate chemistry 20100721

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  Bioconjugate chemistry 20100721

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  Bioconjugate chemistry 20100721

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  European journal of nuclear medicine and molecular imaging 20100701

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  Nuclear medicine and biology 20100701

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  Dalton transactions (Cambridge, England : 2003) 20100628

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  Journal of the American Chemical Society 20100616

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  Organic letters 20100521

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• Magnetic resonance imaging of human glioma cells by means of an interleukin-6 receptor-targeted contrast agent.

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  European journal of nuclear medicine and molecular imaging 20100301

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  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100301

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  Bioorganic & medicinal chemistry 20100201

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  International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20100201

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  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100201

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  Clinical physiology and functional imaging 20100101

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  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100101

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  Nuclear medicine and biology 20100101

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  PloS one 20100101

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  Journal of biomedicine & biotechnology 20100101

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• 68Ga-DOTA-RGD peptide: biodistribution and binding into atherosclerotic plaques in mice.

  European journal of nuclear medicine and molecular imaging 20091201

• Targeting of CCK-2 receptor-expressing tumors using a radiolabeled divalent gastrin peptide.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20091201

• A new bifunctional Gd(III) complex of enhanced efficacy for MR-molecular imaging applications.

  Dalton transactions (Cambridge, England : 2003) 20091128

• Effect of the regiochemistry of butyl amide substituents on the solution-state structures of lanthanide(III) DOTA-tetraamide complexes.

  Inorganic chemistry 20091102

• Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide.

  Bioconjugate chemistry 20091101

• DOTA-M8: An extremely rigid, high-affinity lanthanide chelating tag for PCS NMR spectroscopy.

  Journal of the American Chemical Society 20091021

• Bifunctional phage-based pretargeted imaging of human prostate carcinoma.

  Nuclear medicine and biology 20091001

• In vivo imaging of human colorectal cancer using radiolabeled analogs of the uroguanylin peptide hormone.

  Anticancer research 20091001

• In vitro characterization of (177)Lu-radiolabelled chimeric anti-CD20 monoclonal antibody and a preliminary dosimetry study.

  European journal of nuclear medicine and molecular imaging 20090901

• A 2-helix small protein labeled with 68Ga for PET imaging of HER2 expression.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090901

• Evaluation of a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated bombesin-based radioantagonist for the labeling with single-photon emission computed tomography, positron emission tomography, and therapeutic radionuclides.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090815

• Absolute temperature MR imaging with thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethyl-1,4,7,10-tetraacetic acid (TmDOTMA-).

  Magnetic resonance in medicine 20090801

• Comparative study on DOTA-derivatized bombesin analog labeled with 90Y and 177Lu: in vitro and in vivo evaluation.

  Nuclear medicine and biology 20090801

• Dual functional molecular imaging probe targeting CD20 with PET and optical imaging.

  Oncology reports 20090701

• Development of high-specific-activity (68)Ga-labeled DOTA-rhenium-cyclized alpha-MSH peptide analog to target MC1 receptors overexpressed by melanoma tumors.

  Nuclear medicine and biology 20090701

• Evaluation of a novel radiofolate in tumour-bearing mice: promising prospects for folate-based radionuclide therapy.

  European journal of nuclear medicine and molecular imaging 20090601

• 68Ga-labeling of biotin analogues and their characterization.

  Bioconjugate chemistry 20090601

• Preparation and in vivo imaging of PEG-poly(L-lysine)-based polymeric micelle MRI contrast agents.

  Journal of controlled release : official journal of the Controlled Release Society 20090521

• Glycosylated DOTA-alpha-melanocyte-stimulating hormone analogues for melanoma targeting: influence of the site of glycosylation on in vivo biodistribution.

  Bioconjugate chemistry 20090520

• Gd(iii) complex of a monophosphinate-bis(phosphonate) DOTA analogue with a high relaxivity; Lanthanide(iii) complexes for imaging and radiotherapy of calcified tissues.

  Dalton transactions (Cambridge, England : 2003) 20090507

• A novel neutrophil-specific PET imaging agent: cFLFLFK-PEG-64Cu.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090501

• Radiolabeling of trastuzumab with 177Lu via DOTA, a new radiopharmaceutical for radioimmunotherapy of breast cancer.

  Nuclear medicine and biology 20090501

• A simplified suite of methods to evaluate chelator conjugation of antibodies: effects on hydrodynamic radius and biodistribution.

  Nuclear medicine and biology 20090501

• Quantification and excretion kinetics of a magnetic resonance imaging contrast agent by capillary electrophoresis-mass spectrometry.

  Electrophoresis 20090501

• Noninvasive de novo imaging of human embryonic stem cell-derived teratoma formation.

  Cancer research 20090401

• Noninvasive imaging of alphaVbeta3 function as a predictor of the antimigratory and antiproliferative effects of dasatinib.

  Cancer research 20090401

• SPECT and PET imaging of EGF receptors with site-specifically labeled EGF and dimeric EGF.

  Bioconjugate chemistry 20090401

• Improving tumor uptake and pharmacokinetics of (64)Cu-labeled cyclic RGD peptide dimers with Gly(3) and PEG(4) linkers.

  Bioconjugate chemistry 20090401

• Metastatic melanoma imaging with an (111)In-labeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone peptide.

  Nuclear medicine and biology 20090401

• Engineered knottin peptides: a new class of agents for imaging integrin expression in living subjects.

  Cancer research 20090315

• Synthesis and evaluation of lanthanide ion DOTA-tetraamide complexes bearing peripheral hydroxyl groups.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090301

• A comparative study of 131I and 177Lu labeled somatostatin analogues for therapy of neuroendocrine tumours.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20090201

• Derivation of a compartmental model for quantifying 64Cu-DOTA-RGD kinetics in tumor-bearing mice.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090201

• Development of [(90)Y]DOTA-conjugated bisphosphonate for treatment of painful bone metastases.

  Nuclear medicine and biology 20090201

• Lanthanide(III) complexes of pyridine-N-oxide analogues of DOTA in solution and in the solid state. A new kind of isomerism in complexes of DOTA-like ligands.

  Inorganic chemistry 20090119

• Pyridine-N-oxide analogues of DOTA and their gadolinium(III) complexes endowed with a fast water exchange on the square-antiprismatic isomer.

  Inorganic chemistry 20090119

• Novel cell nucleus directed fluorescent tetraazacyclododecane-tetra-acetic acid compounds.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20090101

• Chemotherapy synergizes with radioimmunotherapy targeting La autoantigen in tumors.

  PloS one 20090101

• Hexa-arginine enhanced uptake and residualization of selective high affinity ligands by Raji lymphoma cells.

  Molecular cancer 20090101

• Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide.

  Molecular imaging 20090101

• Evaluation of [64Cu]Cu-DOTA and [64Cu]Cu-CB-TE2A chelates for targeted positron emission tomography with an alphavbeta6-specific peptide.

  Molecular imaging 20090101

• The effect of the amide substituent on the biodistribution and tolerance of lanthanide(III) DOTA-tetraamide derivatives.

  Investigative radiology 20081201

• Detection of electrophoretically separated cytochromes P450 by element-labelled monoclonal antibodies via laser ablation inductively coupled plasma mass spectrometry.

  Analytical and bioanalytical chemistry 20081101

• Engineered antibody fragments with infinite affinity as reporter genes for PET imaging.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20081101

• Carbonic anhydrase inhibitors: design of membrane-impermeant copper(II) complexes of DTPA-, DOTA-, and TETA-tailed sulfonamides targeting the tumor-associated transmembrane isoform IX.

  ChemMedChem 20081101

• Tetrafluorophenolate of HBED-CC: a versatile conjugation agent for 68Ga-labeled small recombinant antibodies.

  European journal of nuclear medicine and molecular imaging 20081001

• Design, synthesis, and biological evaluation of an antagonist-bombesin analogue as targeting vector.

  Bioconjugate chemistry 20081001

• An osteoclast-targeting agent for imaging and therapy of bone metastasis.

  Bioorganic & medicinal chemistry letters 20080901

• Evaluation of the pharmacokinetic effects of various linking group using the 111In-DOTA-X-BBN(7-14)NH2 structural paradigm in a prostate cancer model.

  Bioconjugate chemistry 20080901

• Rapid and efficient production of radiolabeled antibody conjugates using vacuum diafiltration guided by mathematical modeling.

  Bioconjugate chemistry 20080901

• alpha(v)beta(3) Integrin-targeting radionuclide therapy and imaging with monomeric RGD peptide.

  International journal of cancer 20080801

• Evaluation of a maleimido derivative of CHX-A'' DTPA for site-specific labeling of affibody molecules.

  Bioconjugate chemistry 20080801

• PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080801

• Detailed analysis concerning the biodistribution and metabolism of human calcitonin-derived cell-penetrating peptides.

  Bioconjugate chemistry 20080801

• Imaging of urokinase-type plasminogen activator receptor expression using a 64Cu-labeled linear peptide antagonist by microPET.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20080801

• Cyclin A probes by means of intermolecular sensitization of terbium-chelating peptides.

  Journal of the American Chemical Society 20080730

• Novel DOTA-based prochelator for divalent peptide vectorization: synthesis of dimeric bombesin analogues for multimodality tumor imaging and therapy.

  Chemical communications (Cambridge, England) 20080728

• Novel chemically modified analogues of neuropeptide Y for tumor targeting.

  Bioconjugate chemistry 20080701

• Synthesis of 64Cu-labeled magnetic nanoparticles for multimodal imaging.

  Bioconjugate chemistry 20080701

• The importance of high specific radioactivity in the performance of 68Ga-labeled peptide.

  Nuclear medicine and biology 20080701

• The detection limit of a Gd3+-based T1 agent is substantially reduced when targeted to a protein microdomain.

  Magnetic resonance imaging 20080601

• Synthesis, potentiometric, kinetic, and NMR Studies of 1,4,7,10-tetraazacyclododecane-1,7-bis(acetic acid)-4,10-bis(methylenephosphonic acid) (DO2A2P) and its complexes with Ca(II), Cu(II), Zn(II) and lanthanide(III) ions.

  Inorganic chemistry 20080505

• 111In-labeled galectin-3-targeting peptide as a SPECT agent for imaging breast tumors.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080501

• Bifunctional ligands based on the DOTA-monoamide cage.

  Organic & biomolecular chemistry 20080407

• Value of apoptin's 40-amino-acid C-terminal fragment for the differentiation between human tumor and non-tumor cells.

  Apoptosis : an international journal on programmed cell death 20080401

• Preclinical radioimmunotargeting of folate receptor alpha using the monoclonal antibody conjugate DOTA-MORAb-003.

  Nuclear medicine and biology 20080401

• Antibody-dendrimer conjugates: the number, not the size of the dendrimers, determines the immunoreactivity.

  Bioconjugate chemistry 20080401

• Receptor-binding, biodistribution, and metabolism studies of 64Cu-DOTA-cetuximab, a PET-imaging agent for epidermal growth-factor receptor-positive tumors.

  Cancer biotherapy & radiopharmaceuticals 20080401

• Role of the antenna in tissue selective probes built of lanthanide-organic chelates.

  The journal of physical chemistry. A 20080320

• PET (positron emission tomography) imaging of biomolecules using metal-DOTA complexes: a new collaborative challenge by chemists, biologists, and physicians for future diagnostics and exploration of in vivo dynamics.

  Organic & biomolecular chemistry 20080307

• Novel dual labelled nucleus-directed conjugates containing correct and mutant nuclear localisation sequences.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20080303

• Improved syntheses and applicability of different DOTA building blocks for multiply derivatized scaffolds.

  Bioorganic & medicinal chemistry 20080301

• Lanthanide(III) complexes of bis(phosphonate) monoamide analogues of DOTA: bone-seeking agents for imaging and therapy.

  Journal of medicinal chemistry 20080214

• The synthesis and chelation chemistry of DOTA-peptide conjugates.

  Bioconjugate chemistry 20080201

• Plasma clearance of bacteriophage Qbeta particles as a function of surface charge.

  Journal of the American Chemical Society 20080130

• Development and evaluation of peptidic ligands targeting tumour-associated urokinase plasminogen activator receptor (uPAR) for use in alpha-emitter therapy for disseminated ovarian cancer.

  European journal of nuclear medicine and molecular imaging 20080101

• In vivo imaging of 64Cu-labeled polymer nanoparticles targeted to the lung endothelium.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080101

• In vivo MRI assessment of a novel GdIII-based contrast agent designed for high magnetic field applications.

  Contrast media & molecular imaging 20080101

• New synthesis of a high molecular weight ligand derived from dota; thermodynamic stability of the MRI contrast agent formed with gadolinium.

  Contrast media & molecular imaging 20080101

• Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging.

  Bioorganic & medicinal chemistry letters 20071215

• Kinetic stability studies on yttrium(III)-1,4,7,10- tetraazacyclododecane-1,4,7,10-tetraacetic acid by free-ion selective radiotracer extraction.

  Analytical chemistry 20071215

• A metal-coded affinity tag approach to quantitative proteomics.

  Molecular & cellular proteomics : MCP 20071101

• Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20071101

• MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo.

  Magnetic resonance in medicine 20071001

• Improved tumor targeting and decreased normal tissue accumulation through extracorporeal affinity adsorption in a two-step pretargeting strategy.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070915

• Influence of chelate conjugation on a newly identified tumor-targeting peptide.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070901

• Monopropionate analogues of DOTA4- and DTPA5-: kinetics of formation and dissociation of their lanthanide(III) complexes.

  Dalton transactions (Cambridge, England : 2003) 20070828

• DOTA-PESIN, a DOTA-conjugated bombesin derivative designed for the imaging and targeted radionuclide treatment of bombesin receptor-positive tumours.

  European journal of nuclear medicine and molecular imaging 20070801

• In vivo evaluation and small-animal PET/CT of a prostate cancer mouse model using 64Cu bombesin analogs: side-by-side comparison of the CB-TE2A and DOTA chelation systems.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070801

• Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals?

  European journal of nuclear medicine and molecular imaging 20070701

• The 68Ge/ 68Ga generator has high potential, but when can we use 68Ga-labelled tracers in clinical routine?

  European journal of nuclear medicine and molecular imaging 20070701

• (64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070701

• Preparation and biological evaluation of 111In-, 177Lu- and 90Y-labeled DOTA analogues conjugated to B72.3.

  Nuclear medicine and biology 20070701

• Carbon nanotubes: potential benefits and risks of nanotechnology in nuclear medicine.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070701

• Potentiometric and relaxometric properties of a gadolinium-based MRI contrast agent for sensing tissue pH.

  Inorganic chemistry 20070625

• Synthesis, biodistribution and excretion of radiolabeled poly(2-alkyl-2-oxazoline)s.

  Journal of controlled release : official journal of the Controlled Release Society 20070622

• Evaluation of CD20, CD22, and HLA-DR targeting for radioimmunotherapy of B-cell lymphomas.

  Cancer research 20070615

• Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model.

  Cancer biotherapy & radiopharmaceuticals 20070601

• Results of individual patient dosimetry in peptide receptor radionuclide therapy with 177Lu DOTA-TATE and 177Lu DOTA-NOC.

  Cancer biotherapy & radiopharmaceuticals 20070601

• Preparation of TH227-labeled radioimmunoconjugates, assessment of serum stability and antigen binding ability.

  Cancer biotherapy & radiopharmaceuticals 20070601

• Solid-phase oligonucleotide labeling with DOTA.

  Current protocols in nucleic acid chemistry 20070601

• Indium-labeled macrocyclic conjugates of naltrindole: high-affinity radioligands for in vivo studies of peripheral delta opioid receptors.

  Journal of medicinal chemistry 20070503

• A bridge to coordination isomer selection in lanthanide(III) DOTA-tetraamide complexes.

  Inorganic chemistry 20070402

• In vitro and in vivo comparison of DTPA- and DOTA-conjugated antiferritin monoclonal antibody for imaging and therapy of pancreatic cancer.

  Nuclear medicine and biology 20070401

• Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1,3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and tumor imaging purposes.

  Organic & biomolecular chemistry 20070321

• Alpha v beta 3 integrin-targeting of intraperitoneally growing tumors with a radiolabeled RGD peptide.

  International journal of cancer 20070201

• Reduced myelotoxicity with sustained tumor concentration of radioimmunoconjugates in rats after extracorporeal depletion.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070201

• Somatostatin-receptor-targeted alpha-emitting 213Bi is therapeutically more effective than beta(-)-emitting 177Lu in human pancreatic adenocarcinoma cells.

  Nuclear medicine and biology 20070201

• Gadolinium(III) complexes of mono- and diethyl esters of monophosphonic acid analogue of DOTA as potential MRI contrast agents: solution structures and relaxometric studies.

  Dalton transactions (Cambridge, England : 2003) 20070128

• Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy.

  Cancer research 20070115

• Evaluation of a new biotin-DOTA conjugate for pretargeted antibody-guided radioimmunotherapy (PAGRIT).

  European journal of nuclear medicine and molecular imaging 20070101

• Long-range-distance NMR effects in a protein labeled with a lanthanide-DOTA chelate.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

• Effects of linker variation on the in vitro and in vivo characteristics of an 111In-labeled RGD peptide.

  Nuclear medicine and biology 20070101

• Influence of different spacers on the biological profile of a DOTA-somatostatin analogue.

  Bioconjugate chemistry 20070101

• Synthesis of Poly[APMA]-DOTA-64Cu conjugates for interventional radionuclide therapy of prostate cancer: assessment of intratumoral retention by micro-positron emission tomography.

  Molecular imaging 20070101

• Peptidyl molecular imaging contrast agents using a new solid-phase peptide synthesis approach.

  Bioconjugate chemistry 20070101

• 64Cu-labeled alpha-melanocyte-stimulating hormone analog for microPET imaging of melanocortin 1 receptor expression.

  Bioconjugate chemistry 20070101

• Synthesis and radiolabeling of selective high-affinity ligands designed to target non-Hodgkin's lymphoma and leukemia.

  Bioconjugate chemistry 20070101

• Synthesis of novel 1,4,7,10-tetraazacyclodecane-1,4,7,10-tetraacetic acid (DOTA) derivatives for chemoselective attachment to unprotected polyfunctionalized compounds.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

• In vitro and in vivo evaluation of 64Cu-labeled DOTA-linker-bombesin(7-14) analogues containing different amino acid linker moieties.

  Bioconjugate chemistry 20070101

• Design and synthesis of mono- and multimeric targeted radiopharmaceuticals based on novel cyclen ligands coupled to anti-MUC1 aptamers for the diagnostic imaging and targeted radiotherapy of cancer.

  Bioconjugate chemistry 20070101

• Synthesis and evaluation of intercalating somatostatin receptor binding peptide conjugates for endoradiotherapy.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20070101

• PET imaging of soluble yttrium-86-labeled carbon nanotubes in mice.

  PloS one 20070101

• Labeling of oligonucleotides with DTPA and DOTA on solid phase.

  Nucleosides, nucleotides & nucleic acids 20070101

• Dimeric DOTA-alpha-melanocyte-stimulating hormone analogs: synthesis and in vivo characteristics of radiopeptides with high in vitro activity.

  Journal of receptor and signal transduction research 20070101

• Radiolabelling of glucose-Tyr3-octreotate with 125I and analysis of its metabolism in rats: comparison with radiolabelled DOTA-Tyr3-octreotate.

  Anticancer research 20070101

• Gallium-68 PET: a new frontier in receptor cancer imaging.

  Anticancer research 20070101

• Environmental effects on the structure of metal ion-DOTA complexes: an ab initio study of radiopharmaceutical metals.

  Inorganic chemistry 20061113

• Evaluation of 177Lu-DOTA-labeled aglycosylated monoclonal anti-L1-CAM antibody chCE7: influence of the number of chelators on the in vitro and in vivo properties.

  Nuclear medicine and biology 20061001

• Design, synthesis, and biological evaluation of somatostatin-based radiopeptides.

  Chemistry & biology 20061001

• An HPLC/mass spectrometry platform for the development of multimodality contrast agents and targeted therapeutics: prostate-specific membrane antigen small molecule derivatives.

  Contrast media & molecular imaging 20060901

• In vitro and in vivo magnetic resonance detection of tumor cells by targeting glutamine transporters with Gd-based probes.

  Journal of medicinal chemistry 20060810

• A high-frequency EPR study of frozen solutions of Gd(III) complexes: straightforward determination of the zero-field splitting parameters and simulation of the NMRD profiles.

  Journal of the American Chemical Society 20060621

• Relaxometric and solution NMR structural studies on ditopic lanthanide(III) complexes of a phosphinate analogue of DOTA with a fast rate of water exchange.

  Dalton transactions (Cambridge, England : 2003) 20060521

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• A phase I trial of (90)Y-DOTA-anti-CEA chimeric T84.66 (cT84.66) radioimmunotherapy in patients with metastatic CEA-producing malignancies.

  Cancer biotherapy & radiopharmaceuticals 20060401

• Internalization of sst2, sst3, and sst5 receptors: effects of somatostatin agonists and antagonists.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20060301

• Synthesis of aminooxy-functionalized lanthanide(III) chelates for carbonyl-group conjugation.

  Chemistry & biodiversity 20060301

• Non-invasive temperature imaging with thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethyl-1,4,7,10-tetraacetic acid (TmDOTMA-).

  NMR in biomedicine 20060201

• Improved biodistribution and radioimmunoimaging with poly(ethylene glycol)-DOTA-conjugated anti-CEA diabody.

  Bioconjugate chemistry 20060101

• Radiolanthanide-labeled monoclonal antibody CC49 for radioimmunotherapy of cancer: biological comparison of DOTA conjugates and 149Pm, 166Ho, and 177Lu.

  Bioconjugate chemistry 20060101

• Simple synthesis of a building block for solid-phase labeling of oligonucleotides with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA).

  Bioconjugate chemistry 20060101

• Selective targeting of E. coli heat-stable enterotoxin analogs to human colon cancer cells.

  Anticancer research 20060101

• Targeting of lanthanide(III) chelates of DOTA-type glycoconjugates to the hepatic asyaloglycoprotein receptor: cell internalization and animal imaging studies.

  Contrast media & molecular imaging 20060101

• Conjugation of DOTA-like chelating agents to peptides and radiolabeling with trivalent metallic isotopes.

  Nature protocols 20060101

• Density-functional theory structures of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complexes for ions across the lanthanide series.

  The Journal of chemical physics 20051222

• A bisphosphonate monoamide analogue of DOTA: a potential agent for bone targeting.

  Journal of the American Chemical Society 20051130

• Structural and chiroptical properties of the two coordination isomers of YbDOTA-type complexes.

  Inorganic chemistry 20051114

• Regressive DOTA labelling performance with indium-111 and yttrium-90 over a week of use.

  European journal of nuclear medicine and molecular imaging 20051101

• Development of tumor targeting bioprobes ((111)In-chimeric L6 monoclonal antibody nanoparticles) for alternating magnetic field cancer therapy.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20051001

• Determining maximal tolerable dose of the monoclonal antibody BR96 labeled with 90Y or 177Lu in rats: establishment of a syngeneic tumor model to evaluate means to improve radioimmunotherapy.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20051001

• Does paclitaxel (Taxol) given after (111)In-labeled monoclonal antibodies increase tumor-cumulated activity in epithelial cancers?

  Clinical cancer research : an official journal of the American Association for Cancer Research 20051001

• Blood pharmacokinetics of various monoclonal antibodies labeled with a new trifunctional chelating reagent for simultaneous conjugation with 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid and biotin before radiolabeling.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20051001

• On-resonance low B1 pulses for imaging of the effects of PARACEST agents.

  Journal of magnetic resonance (San Diego, Calif. : 1997) 20050901

• Derivatization of phosphopeptides with mercapto- and amino-functionalized conjugate groups by phosphate elimination and subsequent Michael addition.

  Organic & biomolecular chemistry 20050821

• High-dose radioimmunotherapy combined with fixed, low-dose paclitaxel in metastatic prostate and breast cancer by using a MUC-1 monoclonal antibody, m170, linked to indium-111/yttrium-90 via a cathepsin cleavable linker with cyclosporine to prevent human anti-mouse antibody.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050815

• An estradiol-conjugate for radiolabelling with 177Lu: an attempt to prepare a radiotherapeutic agent.

  Bioorganic & medicinal chemistry 20050701

• Are gadolinium contrast agents suitable for gadolinium neutron capture therapy?

  Neurological research 20050601

• Dendrimeric Gd(III) complex of a monophosphinated DOTA analogue: optimizing relaxivity by reducing internal motion.

  Chemical communications (Cambridge, England) 20050514

• Gallium-68-DOTA-albumin as a PET blood-pool marker: experimental evaluation in vivo.

  Nuclear medicine and biology 20050401

• Noninvasive MR thermometry using paramagnetic lanthanide complexes of 1,4,7,10-tetraazacyclodoecane-alpha,alpha',alpha'',alpha'''-tetramethyl-1,4,7,10-tetraacetic acid (DOTMA4-).

  Magnetic resonance in medicine 20050201

• Synthesis of a bifunctional monophosphinic acid DOTA analogue ligand and its lanthanide(III) complexes. A gadolinium(III) complex endowed with an optimal water exchange rate for MRI applications.

  Organic & biomolecular chemistry 20050107

• Conjugation of DOTA using isolated phenolic active esters: the labeling and biodistribution of albumin as blood pool marker.

  Bioconjugate chemistry 20050101

• MicroPET imaging of MCF-7 tumors in mice via unr mRNA-targeted peptide nucleic acids.

  Bioconjugate chemistry 20050101

• Spectral properties of pro-multimodal imaging agents derived from a NIR dye and a metal chelator.

  Photochemistry and photobiology 20050101

• Synthesis of novel polydiamidopropanoate dendrimer PNA-peptide chimeras for non-invasive magnetic resonance imaging of cancer.

  Nucleosides, nucleotides & nucleic acids 20050101

• Medicinal chemistry of somatostatin analogs leading to the DTPA and DOTA conjugates of the multi-receptor-ligand SOM230.

  Journal of endocrinological investigation 20050101

• Lanthanide(III) complexes of DOTA-glycoconjugates: a potential new class of lectin-mediated medical imaging agents.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20041105

• Quantitation and visualization of tumor-specific T cells in the secondary lymphoid organs during and after tumor elimination by PET.

  Nuclear medicine and biology 20041101

• Complexing mechanism of the lanthanide cations Eu3+, Gd3+, and Tb3+ with 1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (dota)-characterization of three successive complexing phases: study of the thermodynamic and structural properties of the complexes by potentiometry, luminescence spectroscopy, and EXAFS.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20041011

• 68Ga-labelled DOTA-derivatised peptide ligands.

  European journal of nuclear medicine and molecular imaging 20040801

• 177Lu-DOTA-lanreotide: a novel tracer as a targeted agent for tumor therapy.

  Nuclear medicine and biology 20040801

• Conjugates of gadolinium complexes to bile acids as hepatocyte-directed contrast agents for magnetic resonance imaging.

  Journal of medicinal chemistry 20040701

• Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors.

  Nature biotechnology 20040601

• An image worth a thousand lives?

  Nature biotechnology 20040601

• Solution dynamics and stability of lanthanide(III) (S)-2-(p-nitrobenzyl)DOTA complexes.

  Inorganic chemistry 20040503

• Novel gadolinium(III) polyaminocarboxylate macrocyclic complexes as potential magnetic resonance imaging contrast agents.

  Journal of inorganic biochemistry 20040501

• Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes.

  Journal of medicinal chemistry 20040311

• Radioimmunotherapy of prostate cancer in human xenografts using monoclonal antibodies specific to prostate specific membrane antigen (PSMA): studies in nude mice.

  The Prostate 20040201

• Evaluation of a cathepsin-cleavable peptide linked radioimmunoconjugate of a panadenocarcinoma MAb, m170, in mice and patients.

  Cancer biotherapy & radiopharmaceuticals 20040201

• Conformation and structure of polymeric contrast agents for medical imaging.

  Biomacromolecules 20040101

• 90Y and 111In complexes of a DOTA-conjugated integrin alpha v beta 3 receptor antagonist: different but biologically equivalent.

  Bioconjugate chemistry 20040101

• Production and applications of copper-64 radiopharmaceuticals.

  Methods in enzymology 20040101

• Generation of DOTA-conjugated antibody fragments for radioimmunoimaging.

  Methods in enzymology 20040101

• Microwave-supported preparation of (68)Ga bioconjugates with high specific radioactivity.

  Bioconjugate chemistry 20040101

• Synthesis, characterization, and X-ray crystal structure of In(DOTA-AA) (AA = p-aminoanilide): a model for 111In-labeled DOTA-biomolecule conjugates.

  Inorganic chemistry 20031229

• Radioimmunotherapy of non-Hodgkin's lymphoma with 90Y-DOTA humanized anti-CD22 IgG (90Y-Epratuzumab): do tumor targeting and dosimetry predict therapeutic response?

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20031201

• pH-sensitive modulation of the second hydration sphere in lanthanide(III) tetraamide-DOTA complexes: a novel approach to smart MR contrast media.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20031006

• PARACEST agents: modulating MRI contrast via water proton exchange.

  Accounts of chemical research 20031001

• Improved radiotracing of oxytocin receptor-expressing tumours using the new [111In]-DOTA-Lys8-deamino-vasotocin analogue.

  British journal of cancer 20030901

• Synthesis and visualization of a membrane-permeable MRI contrast agent.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20030901

• Preclinical evaluation of cathepsin-degradable peptide linkers for radioimmunoconjugates.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20030901

• Enhanced therapeutic index of radioimmunotherapy (RIT) in prostate cancer patients: comparison of radiation dosimetry for 1,4,7,10-tetraazacyclododecane-N,N',N',N''-tetraacetic acid (DOTA)-peptide versus 2IT-DOTA monoclonal antibody linkage for RIT.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20030901

• Stabilised 111In-labelled DTPA- and DOTA-conjugated neurotensin analogues for imaging and therapy of exocrine pancreatic cancer.

  European journal of nuclear medicine and molecular imaging 20030801

• Synthesis and evaluation of novel bifunctional chelating agents based on 1,4,7,10-tetraazacyclododecane-N,N',N',N''-tetraacetic acid for radiolabeling proteins.

  Nuclear medicine and biology 20030801

• Design, synthesis, and evaluation of radiolabeled integrin alpha v beta 3 receptor antagonists for tumor imaging and radiotherapy.

  Cancer biotherapy & radiopharmaceuticals 20030801

• A new biotin derivative-DOTA conjugate as a candidate for pretargeted diagnosis and therapy of tumors.

  Journal of medicinal chemistry 20030703

• Optimising conditions for radiolabelling of DOTA-peptides with 90Y, 111In and 177Lu at high specific activities.

  European journal of nuclear medicine and molecular imaging 20030601

• DOTA alpha-melanocyte-stimulating hormone analogues for imaging metastatic melanoma lesions.

  Annals of the New York Academy of Sciences 20030601

• Preparation and in vitro evaluation of GdDOTA-(BOM)4; a novel angiographic MRI contrast agent.

  Organic & biomolecular chemistry 20030521

• Equilibrium, 1H and 13C NMR spectroscopy, and X-ray diffraction studies on the complexes Bi(DOTA)- and Bi(DO3A-Bu).

  Inorganic chemistry 20030407

• A rare earth-DOTA-binding antibody: probe properties and binding affinity across the lanthanide series.

  Journal of the American Chemical Society 20030326

• Isotachophoretic determination of stability constants of Ho and Y complexes with diethylenetriaminepentaacetic acid and 1,4,7,10-tetraazadodecane-N,N',N'',N'''-tetraacetic acid.

  Journal of chromatography. A 20030321

• Comparison of immunoscintigraphy, efficacy, and toxicity of conventional and pretargeted radioimmunotherapy in CD20-expressing human lymphoma xenografts.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030301

• The addition of DTPA to [177Lu-DOTA0,Tyr3]octreotate prior to administration reduces rat skeleton uptake of radioactivity.

  European journal of nuclear medicine and molecular imaging 20030201

• 90Y-DOTA-hLL2: an agent for radioimmunotherapy of non-Hodgkin's lymphoma.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030101

• Radiolabeled alpha-melanocyte-stimulating hormone analogs for receptor-mediated targeting of melanoma: from tritium to indium.

  Journal of molecular recognition : JMR 20030101

• Synthesis of radiometal-labeled and fluorescent cell-permeating peptide-PNA conjugates for targeting the bcl-2 proto-oncogene.

  Bioconjugate chemistry 20030101

• Towards the rational design of magnetic resonance imaging contrast agents: isolation of the two coordination isomers of lanthanide DOTA-type complexes.

  Angewandte Chemie (International ed. in English) 20030101

• A novel DOTA-alpha-melanocyte-stimulating hormone analog for metastatic melanoma diagnosis.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20021201

• Evaluation of 90Y-DTPA and 90Y-DOTA for potential application in intra-vascular radionuclide therapy.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20020901

• From monomers to micelles: investigation of the parameters influencing proton relaxivity.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20020901

• Early distribution dynamics of polymeric magnetic resonance imaging contrast agents in rats.

  Academic radiology 20020801

• Synthesis and evaluation of a monoreactive DOTA derivative for indium-111-based residualizing label to estimate protein pharmacokinetics.

  The Journal of pharmacy and pharmacology 20020801

• Modification of the structure of a metallopeptide: synthesis and biological evaluation of (111)In-labeled DOTA-conjugated rhenium-cyclized alpha-MSH analogues.

  Journal of medicinal chemistry 20020704

• Pretargeting radioimmunotherapy of a murine model of adult T-cell leukemia with the alpha-emitting radionuclide, bismuth 213.

  Blood 20020701

• Conformational characterization of lanthanide(III)-DOTA complexes by ab initio investigation in vacuo and in aqueous solution.

  Journal of the American Chemical Society 20020501

• Optimization of the small-scale synthesis of DOTA-Tyr3 -octreotide.

  Nuclear medicine communications 20020501

• Formation kinetics and stability studies on the lanthanide complexes of 1,4,7,10-tetraazacyclododecane-N,N',N',N''-tetraacetic acid by capillary electrophoresis.

  Electrophoresis 20020501

• Pm-149 DOTA bombesin analogs for potential radiotherapy. in vivo comparison with Sm-153 and Lu-177 labeled DO3A-amide-betaAla-BBN(7-14)NH(2).

  Nuclear medicine and biology 20020501

• In vivo comparison of macrocyclic and acyclic ligands for radiolabeling of monoclonal antibodies with 177Lu for radioimmunotherapeutic applications.

  Nuclear medicine and biology 20020501

• Neuroendocrine tumor targeting: study of novel gallium-labeled somatostatin radiopeptides in a rat pancreatic tumor model.

  International journal of cancer 20020420

• Paramagnetic lanthanide(III) complexes as pH-sensitive chemical exchange saturation transfer (CEST) contrast agents for MRI applications.

  Magnetic resonance in medicine 20020401

• Alpha-melanocyte-stimulating hormone peptide analogs labeled with technetium-99m and indium-111 for malignant melanoma targeting.

  Cancer 20020215

• Vinyl sulfone bifunctional derivatives of DOTA allow sulfhydryl- or amino-directed coupling to antibodies. Conjugates retain immunoreactivity and have similar biodistributions.

  Bioconjugate chemistry 20020101

• Chemical synthesis of Escherichia coli ST(h) analogues by regioselective disulfide bond formation: biological evaluation of an (111)In-DOTA-Phe(19)-ST(h) analogue for specific targeting of human colon cancers.

  Bioconjugate chemistry 20020101

• Non-invasive magnetic resonance thermometry using thulium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (TmDOTA(-)).

  International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20020101

• Comparison of yttrium and indium complexes of DOTA-BA and DOTA-MBA: models for (90)Y- and (111)In-labeled DOTA-biomolecule conjugates.

  Bioconjugate chemistry 20020101

• Trifunctional conjugation reagents. Reagents that contain a biotin and a radiometal chelation moiety for application to extracorporeal affinity adsorption of radiolabeled antibodies.

  Bioconjugate chemistry 20020101

• Toxicity and dosimetry of (177)Lu-DOTA-Y3-octreotate in a rat model.

  International journal of cancer 20011215

• Evaluation of an (111)In-DOTA-rhenium cyclized alpha-MSH analog: a novel cyclic-peptide analog with improved tumor-targeting properties.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20011201

• Anti-HLA-DR/anti-DOTA diabody construction in a modular gene design platform: bispecific antibodies for pretargeted radioimmunotherapy.

  Cancer biotherapy & radiopharmaceuticals 20011201

• Tumor therapy with targeted atomic nanogenerators.

  Science (New York, N.Y.) 20011116

• Molecular modeling of bifunctional chelate peptide conjugates. 1. Copper and indium parameters for the AMBER force field.

  Inorganic chemistry 20010924

• Ligand preorganization in metal ion complexation: molecular mechanics/dynamics, kinetics, and laser-excited luminescence studies of trivalent lanthanide complex formation with macrocyclic ligands TETA and DOTA.

  Inorganic chemistry 20010702

• TmDOTA-: a sensitive probe for MR thermometry in vivo.

  Journal of magnetic resonance (San Diego, Calif. : 1997) 20010701

• 111In-labeled 1,4,7,10-tetraazacyclododecane-N,N',N',N''-tetraacetic acid-lys(8)-vasotocin: a new powerful radioligand for oxytocin receptor-expressing tumors.

  Cancer research 20010601

• Radioimmunotherapy of a human lung cancer xenograft with monoclonal antibody RS7: evaluation of (177)Lu and comparison of its efficacy with that of (90)Y and residualizing (131)I.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20010601

• Relaxivity and water exchange studies of a cationic macrocyclic gadolinium(III) complex.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20010401

• Frequency decoding of fast calcium oscillations by calpain.

  Cell calcium 20010301

• [DOTA-bis(amide)]lanthanide complexes: NMR evidence for differences in water-molecule exchange rates for coordination isomers.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20010105

• Size optimization of synthetic graft copolymers for in vivo angiogenesis imaging.

  Bioconjugate chemistry 20010101

• Tumor targeting of radiometal labeled anti-CEA recombinant T84.66 diabody and t84.66 minibody: comparison to radioiodinated fragments.

  Bioconjugate chemistry 20010101

• Metabolism and renal clearance of 111In-labeled DOTA-conjugated antibody fragments.

  Bioconjugate chemistry 20010101

• An improved method for conjugating monoclonal antibodies with N-hydroxysulfosuccinimidyl DOTA.

  Bioconjugate chemistry 20010101

• Stabilization of (90)y-labeled DOTA-biomolecule conjugates using gentisic acid and ascorbic acid.

  Bioconjugate chemistry 20010101

• (90)Y and (177)Lu labeling of a DOTA-conjugated vitronectin receptor antagonist useful for tumor therapy.

  Bioconjugate chemistry 20010101

• DOTA tris(phenylmethyl) ester: a new useful synthon for the synthesis of DOTA monoamides containing acid-labile bonds.

  Bioconjugate chemistry 20010101

• Antibody responses to macrocycles in lymphoma.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 19960301