6027-21-0 | D-Homoserine

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$6.00	$4.00
1g	95%	in stock	$8.00	$5.00
5g	95%	in stock	$25.00	$17.00
10g	95%	in stock	$33.00	$23.00
25g	95%	in stock	$73.00	$51.00

Description

• Catalog Number: AB45853
• Chemical Name: D-Homoserine
• CAS Number: 6027-21-0
• Molecular Formula: C4H9NO3
• Molecular Weight: 119.1192
• MDL Number: MFCD00077786
• SMILES: OCC[C@H](C(=O)O)N

Computed Properties

• Complexity: 83.4
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 8
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 3
• XLogP3: -4.4

Literature

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• Temperature, not LuxS, mediates AI-2 formation in hydrothermal habitats.

  FEMS microbiology ecology 20090501

• Influence of Pseudomonas aeruginosa quorum sensing signal molecule N-(3-oxododecanoyl) homoserine lactone on mast cells.

  Medical microbiology and immunology 20090501

• Biological activity and identification of a peptide inhibitor of LuxS from Streptococcus suis serotype 2.

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• Quantifying the integration of quorum-sensing signals with single-cell resolution.

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• An isocratic fluorescence HPLC assay for the monitoring of l-asparaginase activity and l-asparagine depletion in children receiving E. colil-asparaginase for the treatment of acute lymphoblastic leukaemia.

  Biomedical chromatography : BMC 20090201

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  Experimental cell research 20090115

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  BMC microbiology 20090101

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  BMC microbiology 20090101

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  The ISME journal 20081201

• Biofilm formation and autoinducer-2 signaling in Streptococcus intermedius: role of thermal and pH factors.

  Oral microbiology and immunology 20081201

• Sinorhizobium meliloti, a bacterium lacking the autoinducer-2 (AI-2) synthase, responds to AI-2 supplied by other bacteria.

  Molecular microbiology 20081201

• Autoinducer-2 is produced in saliva-fed flow conditions relevant to natural oral biofilms.

  Journal of applied microbiology 20081201

• A bacterial small molecule undermining immune response signaling.

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• Role of RpoS in stress survival, synthesis of extracellular autoinducer 2, and virulence in Vibrio alginolyticus.

  Archives of microbiology 20081101

• Investigating the effect of patulin, penicillic acid and EDTA on biofilm formation of isolates from dental unit water lines.

  Applied microbiology and biotechnology 20081101

• Directed evolution of LuxI for enhanced OHHL production.

  Biotechnology and bioengineering 20081001

• Indole cell signaling occurs primarily at low temperatures in Escherichia coli.

  The ISME journal 20081001

• PCR detection of Serratia spp. using primers targeting pfs and luxS genes involved in AI-2-dependent quorum sensing.

  Current microbiology 20081001

• Enhanced biofilm formation and reduced virulence of Actinobacillus pleuropneumoniae luxS mutant.

  Microbial pathogenesis 20080901

• Threonine biosynthetic genes are essential in Cryptococcus neoformans.

  Microbiology (Reading, England) 20080901

• [Influence of mutations at genes of global transcriptional regulators on production of autoinducer AI-2 Quorum Sensing in the system of Escherichia coli].

  Genetika 20080901

• Analysis of AI-2/LuxS-dependent transcription in Campylobacter jejuni strain 81-176.

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• Bacteriophage-amplified bioluminescent sensing of Escherichia coli O157:H7.

  Analytical and bioanalytical chemistry 20080501

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  Molecular immunology 20080501

• The Pseudomonas aeruginosa autoinducer dodecanoyl-homoserine lactone inhibits the putrescine synthesis in human cells.

  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20080501

• Pseudomonas aeruginosa quorum-sensing signal molecules induce IL-8 production by human corneal epithelial cells.

  Eye & contact lens 20080501

• Raney-Co mediated reductive cyclization of an alpha,beta-unsaturated nitrile.

  The Journal of organic chemistry 20080418

• Temporal regulation of enterohemorrhagic Escherichia coli virulence mediated by autoinducer-2.

  Applied microbiology and biotechnology 20080401

• Autoinducer AI-2 is involved in regulating a variety of cellular processes in Salmonella Typhimurium.

  Foodborne pathogens and disease 20080401

• Influence of autoinducer-2 (AI-2) and beef sample extracts on E. coli O157:H7 survival and gene expression of virulence genes yadK and hhA.

  Journal of food science 20080401

• Autoinducer-2 activity of gram-negative foodborne pathogenic bacteria and its influence on biofilm formation.

  Journal of food science 20080401

• Regulation of Vibrio alginolyticus virulence by the LuxS quorum-sensing system.

  Journal of fish diseases 20080301

• Oxazaborolidine derivatives inducing autoinducer-2 signal transduction in Vibrio harveyi.

  Bioorganic & medicinal chemistry 20080215

• A LuxP-based fluorescent sensor for bacterial autoinducer II.

  ACS chemical biology 20080215

• Regulation of aspartate-derived amino acid homeostasis in potato plants (Solanum tuberosum L.) by expression of E. coli homoserine kinase.

  Amino acids 20080201

• Stimulation of Fusobacterium nucleatum biofilm formation by Porphyromonas gingivalis.

  Oral microbiology and immunology 20080201

• LuxS and expression of virulence factors in Streptococcus intermedius.

  Oral microbiology and immunology 20080201

• AI-2-dependent gene regulation in Staphylococcus epidermidis.

  BMC microbiology 20080101

• Potential for luxS related signalling in marine bacteria and production of autoinducer-2 in the genus Shewanella.

  BMC microbiology 20080101

• Identification of ground beef-derived fatty acid inhibitors of autoinducer-2-based cell signaling.

  Journal of food protection 20080101

• Detection and inhibition of bacterial cell-cell communication.

  Methods in molecular biology (Clifton, N.J.) 20080101

• [Detection of quorum-sensing pathway and construction of luxS gene allelic exchange plasmid of Streptococcus mutans].

  Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 20080101

• Practical considerations for the analysis of ionic and neutral organic molecules with capillary electrophoresis/mass spectrometry.

  Methods in molecular biology (Clifton, N.J.) 20080101

• LuxS-independent formation of AI-2 from ribulose-5-phosphate.

  BMC microbiology 20080101

• Detection of possible AI-2-mediated quorum sensing system in commensal intestinal bacteria.

  Folia microbiologica 20080101

• Lack of genomic evidence of AI-2 receptors suggests a non-quorum sensing role for luxS in most bacteria.

  BMC microbiology 20080101

• Functional analysis of the group A streptococcal luxS/AI-2 system in metabolism, adaptation to stress and interaction with host cells.

  BMC microbiology 20080101

• Bacillus megaterium CYP102A1 oxidation of acyl homoserine lactones and acyl homoserines.

  Biochemistry 20071218

• The possible influence of LuxS in the in vivo virulence of rabbit enteropathogenic Escherichia coli.

  Veterinary microbiology 20071215

• Duplication of a conditionally dispensable chromosome carrying pea pathogenicity (PEP) gene clusters in Nectria haematococca.

  Molecular plant-microbe interactions : MPMI 20071201

• Influence of enteric bacteria conditioned media on recovery of Escherichia coli O157:H7 exposed to starvation and sodium hypochlorite.

  Journal of applied microbiology 20071101

• Identification of poultry meat-derived fatty acids functioning as quorum sensing signal inhibitors to autoinducer-2 (AI-2).

  Journal of food science 20071101

• Synthetic bromated furanone inhibits autoinducer-2-mediated communication and biofilm formation in oral streptococci.

  Oral microbiology and immunology 20071001

• The role of luxS in the fire blight pathogen Erwinia amylovora is limited to metabolism and does not involve quorum sensing.

  Molecular plant-microbe interactions : MPMI 20071001

• Substrate analysis of homoserine acyltransferase from Bacillus cereus.

  Biochemical and biophysical research communications 20070921

• The quorum-sensing molecule autoinducer 2 regulates motility and flagellar morphogenesis in Helicobacter pylori.

  Journal of bacteriology 20070901

• The hydrolysis of unsubstituted N-acylhomoserine lactones to their homoserine metabolites. Analytical approaches using ultra performance liquid chromatography.

  Journal of chromatography. A 20070810

• Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria.

  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20070729

• Quorum-sensing regulation in rhizobia and its role in symbiotic interactions with legumes.

  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20070729

• Look who's talking: communication and quorum sensing in the bacterial world.

  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20070729

• Quorum sensing in Serratia.

  FEMS microbiology reviews 20070701

• Synthesis of bisaminoacylated pdCpAs and tandemly activated transfer RNAs.

  Bioorganic & medicinal chemistry 20070701

• AI-2 quorum sensing affects antibiotic susceptibility in Streptococcus anginosus.

  The Journal of antimicrobial chemotherapy 20070701

• The dosage of small volumes for chromatographic quantifications using a drop-on-demand dispenser system.

  Analytical and bioanalytical chemistry 20070701

• Genetic and physiological characterization of the Borrelia burgdorferi ORF BB0374-pfs-metK-luxS operon.

  Microbiology (Reading, England) 20070701

• Bacteriophage-based bioluminescent bioreporter for the detection of Escherichia coli 0157:H7.

  Journal of food protection 20070601

• Assessing the roles of essential functional groups in the mechanism of homoserine succinyltransferase.

  Archives of biochemistry and biophysics 20070515

• Biofilm formation by Propionibacterium acnes is associated with increased resistance to antimicrobial agents and increased production of putative virulence factors.

  Research in microbiology 20070501

• [Molecular genetic analysis for oral biofilm formation].

  Nihon saikingaku zasshi. Japanese journal of bacteriology 20070501

• A LuxP-FRET-based reporter for the detection and quantification of AI-2 bacterial quorum-sensing signal compounds.

  Biochemistry 20070403

• Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia.

  American journal of physiology. Lung cellular and molecular physiology 20070401

• Rhizobitoxine production in Agrobacterium tumefaciens C58 by Bradyrhizobium elkanii rtxACDEFG genes.

  FEMS microbiology letters 20070401

• Characterization of a phenazine-producing strain Pseudomonas chlororaphis GP72 with broad-spectrum antifungal activity from green pepper rhizosphere.

  Current microbiology 20070401

• Ac2-DPD, the bis-(O)-acetylated derivative of 4,5-dihydroxy-2,3-pentanedione (DPD) is a convenient stable precursor of bacterial quorum sensing autoinducer AI-2.

  Bioorganic & medicinal chemistry letters 20070301

• Magnetic nanofactories: localized synthesis and delivery of quorum-sensing signaling molecule autoinducer-2 to bacterial cell surfaces.

  Metabolic engineering 20070301

• Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria.

  ACS chemical biology 20070220

• Bacterial signal destruction.

  ACS chemical biology 20070220

• Synthesis of [1,2-13C2, 15N]-L-homoserine and its incorporation by the PKS-NRPS system of Fusarium moniliforme into the mycotoxin fusarin C.

  Chembiochem : a European journal of chemical biology 20070102

• The quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) enhances the host defence by activating human polymorphonuclear neutrophils (PMN).

  Analytical and bioanalytical chemistry 20070101

• Beyond quorum sensing: the complexities of prokaryotic parliamentary procedures.

  Analytical and bioanalytical chemistry 20070101

• Bacterial quorum sensing and interference by naturally occurring biomimics.

  Analytical and bioanalytical chemistry 20070101

• Autoinducer-2 of the fire blight pathogen Erwinia amylovora and other plant-associated bacteria.

  FEMS microbiology letters 20070101

• Use of quantitative real-time RT-PCR to analyse the expression of some quorum-sensing regulated genes in Pseudomonas aeruginosa.

  Analytical and bioanalytical chemistry 20070101

• Analysing traces of autoinducer-2 requires standardization of the Vibrio harveyi bioassay.

  Analytical and bioanalytical chemistry 20070101

• Differential expression of virulence-related genes in A Salmonella enterica serotype typhimurium luxS mutant in response to autoinducer AI-2 and poultry meat-derived AI-2 inhibitor.

  Foodborne pathogens and disease 20070101

• Autoinducer production and quorum-sensing dependent phenotypes of Pseudomonas aeruginosa vary according to isolation site during colonization of intubated patients.

  BMC microbiology 20070101

• The immunomodulatory Pseudomonas aeruginosa signalling molecule N-(3-oxododecanoyl)-L-homoserine lactone enters mammalian cells in an unregulated fashion.

  Immunology and cell biology 20070101

• The regulation of histidine sensor kinase complexes by quorum sensing signal molecules.

  Methods in enzymology 20070101

• Synthesis of the functionalizable methionine surrogate azidohomoalanine using Boc-homoserine as precursor.

  Nature protocols 20070101

• Quorum sensing: fact, fiction, and everything in between.

  Advances in applied microbiology 20070101

• Functional quorum sensing systems affect biofilm formation and protein expression in Yersinia pestis.

  Advances in experimental medicine and biology 20070101

• Pseudomonas aeruginosa quorum sensing molecule N-(3 oxododecanoyl)-l-homoserine lactone disrupts epithelial barrier integrity of Caco-2 cells.

  FEBS letters 20061222

• Biosensing systems for the detection of bacterial quorum signaling molecules.

  Analytical chemistry 20061115

• Mutation of luxS affects motility and infectivity of Helicobacter pylori in gastric mucosa of a Mongolian gerbil model.

  Journal of medical microbiology 20061101

• Gas-phase regiocontrolled generation of charged amino acid and peptide radicals.

  Chemical communications (Cambridge, England) 20061028

• Synthesis and immunobiological activity of an original series of acyclic lipid a mimics based on a pseudodipeptide backbone.

  Journal of medicinal chemistry 20061005

• Pseudomonas aeruginosa autoinducer modulates host cell responses through calcium signalling.

  Cellular microbiology 20061001

• Immunization with 3-oxododecanoyl-L-homoserine lactone-protein conjugate protects mice from lethal Pseudomonas aeruginosa lung infection.

  Journal of medical microbiology 20061001

• Transmembrane signaling by asymmetry.

  Nature structural & molecular biology 20061001

• Enhanced phenol biodegradation and aerobic granulation by two coaggregating bacterial strains.

  Environmental science & technology 20061001

• Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing.

  Cell 20060922

• Autoinducer-2 bioassay is a qualitative, not quantitative method influenced by glucose.

  Journal of microbiological methods 20060901

• Isolation and functional analysis of luxS in Serratia plymuthica RVH1.

  FEMS microbiology letters 20060901

• PtxR modulates the expression of QS-controlled virulence factors in the Pseudomonas aeruginosa strain PAO1.

  Molecular microbiology 20060801

• [Quorum sensing: a new clinical target for Pseudomonas aeruginosa?].

  Medecine et maladies infectieuses 20060701

• Aspartic acid 214 in Citrobacter freundii tyrosine phenol-lyase ensures sufficient C--H-acidity of the external aldimine intermediate and proper orientation of the cofactor at the active site.

  Biochimica et biophysica acta 20060701

• The presence of a conjugative Gram-positive Tn2009 in Gram-negative commensal bacteria.

  The Journal of antimicrobial chemotherapy 20060601

• Autoinducer 2: a concentration-dependent signal for mutualistic bacterial biofilm growth.

  Molecular microbiology 20060601

• Cooperation of two distinct ExpR regulators controls quorum sensing specificity and virulence in the plant pathogen Erwinia carotovora.

  Molecular microbiology 20060601

• Functionality of Borrelia burgdorferi LuxS: the Lyme disease spirochete produces and responds to the pheromone autoinducer-2 and lacks a complete activated-methyl cycle.

  International journal of medical microbiology : IJMM 20060501

• Type II quorum sensing regulates virulence in Erwinia carotovora ssp. carotovora.

  FEMS microbiology letters 20060501

• Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages.

  Bioorganic & medicinal chemistry letters 20060415

• Quorum sensing in Escherichia coli and Salmonella.

  International journal of medical microbiology : IJMM 20060401

• Quorum sensing in vibrios: complexity for diversification.

  International journal of medical microbiology : IJMM 20060401

• Immune modulation by Pseudomonas aeruginosa quorum-sensing signal molecules.

  International journal of medical microbiology : IJMM 20060401

• Functional analysis of luxS in Staphylococcus aureus reveals a role in metabolism but not quorum sensing.

  Journal of bacteriology 20060401

• Let LuxS speak up in AI-2 signaling.

  Trends in microbiology 20060301

• Bacterial small-molecule signaling pathways.

  Science (New York, N.Y.) 20060224

• N-acylhomoserine lactones antagonize virulence gene expression and quorum sensing in Staphylococcus aureus.

  Infection and immunity 20060201

• Diptericin expression in bacteria infected Drosophila mbn-2 cells - effect of infection dose and phagocytosis.

  Insect molecular biology 20060201

• Structure of the Escherichia coli quorum sensing protein SdiA: activation of the folding switch by acyl homoserine lactones.

  Journal of molecular biology 20060113

• Simple electrospray mass spectrometry detection of acylhomoserine lactones.

  Luminescence : the journal of biological and chemical luminescence 20060101

• Engineering d-amino acid containing novel protease inhibitors using catalytic site architecture.

  Bioorganic & medicinal chemistry 20060101

• Quantification of S-adenosyl methionine in microbial cell extracts.

  Biotechnology letters 20060101

• Evidence for quorum sensing in Clostridium botulinum 56A.

  Letters in applied microbiology 20060101

• Quorum sensing and the lifestyle of Yersinia.

  Current issues in molecular biology 20060101

• Quorum sensing: the many languages of bacteria.

  FEMS microbiology letters 20060101

• Presence of LuxS/AI-2 based quorum-sensing system in Vibrio mimicus : luxO controls protease activity.

  Microbiology and immunology 20060101

• Controlling biofilms of gram-positive pathogenic bacteria.

  Current medicinal chemistry 20060101

• Bacterial interactions and successions during plaque development.

  Periodontology 2000 20060101

• The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone stimulates phagocytic activity in human macrophages through the p38 MAPK pathway.

  Microbes and infection 20051201

• Modelling antibiotic- and anti-quorum sensing treatment of a spatially-structured Pseudomonas aeruginosa population.

  Journal of mathematical biology 20051101

• [Topics in Quorum-sensing research: from inter-species, inter-kingdom communication to recognition of host responses by bacteria].

  Nihon saikingaku zasshi. Japanese journal of bacteriology 20051101

• Interrupters on the bacterial party line.

  Nature chemical biology 20051101

• Thieves, assassins and spies of the microbial world.

  Nature cell biology 20051001

• N-Acylhomoserine lactone quorum-sensing molecules are modified and degraded by Rhodococcus erythropolis W2 by both amidolytic and novel oxidoreductase activities.

  Microbiology (Reading, England) 20051001

• Alleviation of insulitis and moderation of diabetes in NOD mice following treatment with a synthetic Pseudomonas aeruginosa signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone.

  Acta diabetologica 20051001

• Interference with AI-2-mediated bacterial cell-cell communication.

  Nature 20050929

• Small molecule inhibitors of bacterial quorum sensing and biofilm formation.

  Journal of the American Chemical Society 20050921

• Haemophilus influenzae luxS mutants form a biofilm and have increased virulence.

  Microbial pathogenesis 20050901

• Mutational analysis of a nucleosidase involved in quorum-sensing autoinducer-2 biosynthesis.

  Biochemistry 20050823

• The impact of mutations in the quorum sensing systems of Aeromonas hydrophila, Vibrio anguillarum and Vibrio harveyi on their virulence towards gnotobiotically cultured Artemia franciscana.

  Environmental microbiology 20050801

• Evolutionary plasticity of methionine biosynthesis.

  Gene 20050801

• Enhancement of 5-fluorouracil sensitivity by an rTS signaling mimic in H630 colon cancer cells.

  Cancer research 20050701

• Purification and characterization of mouse hepatic enzyme that converts selenomethionine to methylselenol by its alpha,gamma-elimination.

  Biological trace element research 20050701

• Methods for analysis of bacterial autoinducer-2 production.

  Current protocols in microbiology 20050701

• Biosynthetic precursors of fungal pyrrolizidines, the loline alkaloids.

  Chembiochem : a European journal of chemical biology 20050601

• The two-component response regulator PprB modulates quorum-sensing signal production and global gene expression in Pseudomonas aeruginosa.

  Molecular microbiology 20050601

• Regulation of LuxPQ receptor activity by the quorum-sensing signal autoinducer-2.

  Molecular cell 20050527

• Chemical synthesis of (S)-4,5-dihydroxy-2,3-pentanedione, a bacterial signal molecule precursor, and validation of its activity in Salmonella typhimurium.

  The Journal of biological chemistry 20050520

• Quorum sensing in Vibrio harveyi: probing the specificity of the LuxP binding site.

  Bioorganic & medicinal chemistry letters 20050502

• Novel quorum-sensing-controlled genes in Erwinia carotovora subsp. carotovora: identification of a fungal elicitor homologue in a soft-rotting bacterium.

  Molecular plant-microbe interactions : MPMI 20050401

• Identification of N-acylhomoserine lactones in mucopurulent respiratory secretions from cystic fibrosis patients.

  FEMS microbiology letters 20050315

• Functional demonstration of reverse transsulfuration in the Mycobacterium tuberculosis complex reveals that methionine is the preferred sulfur source for pathogenic Mycobacteria.

  The Journal of biological chemistry 20050304

• Methionine and threonine synthesis are limited by homoserine availability and not the activity of homoserine kinase in Arabidopsis thaliana.

  The Plant journal : for cell and molecular biology 20050301

• Identification of amino acid residues of the Agrobacterium tumefaciens quorum-sensing regulator TraR that are critical for positive control of transcription.

  Molecular microbiology 20050301

• Autoinducer 2-like activity in poultry-associated enteric bacteria in response to subtherapeutic antibiotic exposure.

  Avian diseases 20050301

• Disruption of quorum sensing in seawater abolishes attraction of zoospores of the green alga Ulva to bacterial biofilms.

  Environmental microbiology 20050201

• The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-L-homoserine lactones.

  Molecular microbiology 20050201

• The use of quorum-sensing blockers as therapeutic agents for the control of biofilm-associated infections.

  Current opinion in investigational drugs (London, England : 2000) 20050201

• Homoserine-derived cyclic sulfamidate as chiral educt for the diversity-oriented synthesis of lactam-bridged dipeptides.

  Biopolymers 20050101

• Autoinducer-2-like activity on vegetable produce and its potential involvement in bacterial biofilm formation on tomatoes.

  Foodborne pathogens and disease 20050101

• Differential gene expression shows natural brominated furanones interfere with the autoinducer-2 bacterial signaling system of Escherichia coli.

  Biotechnology and bioengineering 20041205

• A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology.

  Molecular microbiology 20041201

• Saccharomyces cerevisiae Aqr1 is an internal-membrane transporter involved in excretion of amino acids.

  Eukaryotic cell 20041201

• Synthesis and stability of small molecule probes for Pseudomonas aeruginosa quorum sensing modulation.

  Organic & biomolecular chemistry 20041121

• Probing the active site of homoserine trans-succinylase.

  FEBS letters 20041119

• Molecular characterization and transcription of the luxS gene that encodes LuxS autoinducer 2 synthase in Streptococcus bovis.

  Current microbiology 20041101

• Role of quorum sensing in the pathogenicity of Burkholderia pseudomallei.

  Journal of medical microbiology 20041101

• N-Sulfonyl homoserine lactones as antagonists of bacterial quorum sensing.

  Bioorganic & medicinal chemistry letters 20041018

• Synthesis and immunological evaluation of an antitumor neoglycopeptide vaccine bearing a novel homoserine Tn antigen.

  Bioorganic & medicinal chemistry letters 20040705

• Autoinducer-2-like activity associated with foods and its interaction with food additives.

  Journal of food protection 20040701

• luxS mutants of Serratia defective in autoinducer-2-dependent 'quorum sensing' show strain-dependent impacts on virulence and production of carbapenem and prodigiosin.

  Microbiology (Reading, England) 20040601

• Cell-to-cell signalling in Escherichia coli and Salmonella enterica.

  Molecular microbiology 20040501

• Role of homoserine and threonine pathway intermediates as precursors for the biosynthesis of aminoethoxyvinylglycine in Streptomyces sp. NRRL 5331.

  Microbiology (Reading, England) 20040501

• Synthesis and biological validation of a ubiquitous quorum-sensing molecule.

  Angewandte Chemie (International ed. in English) 20040413

• Increased expression of Borrelia burgdorferi factor H-binding surface proteins during transmission from ticks to mice.

  International journal of medical microbiology : IJMM 20040401

• L-Homoserylaminoethanol, a novel dipeptide alcohol inhibitor of eukaryotic DNA polymerase from a plant cultured cells, Nicotina tabacum L.

  Bioorganic & medicinal chemistry 20040301

• Biofilms, homoserine lactones and biocide susceptibility.

  The Journal of antimicrobial chemotherapy 20040201

• Talking bacteria.

  Scientific American 20040201

• L-O-Caffeoylhomoserine from Matteuccia struthiopteris.

  Phytochemistry 20040201

• Biofilm formation and cell-to-cell signalling in Gram-negative bacteria isolated from a food processing environment.

  Journal of applied microbiology 20040101

• Direct analysis of selected N-acyl-L-homoserine lactones by gas chromatography/mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20040101

• Modeling the quorum sensing regulatory network of human-pathogenic Pseudomonas aeruginosa.

  Biotechnology progress 20040101

• Is autoinducer-2 a universal signal for interspecies communication: a comparative genomic and phylogenetic analysis of the synthesis and signal transduction pathways.

  BMC evolutionary biology 20040101

• Cell-to-cell communication in bacteria: a chemical discourse.

  Harvey lectures 20040101

• Modulation of Pseudomonas aeruginosa gene expression by host microflora through interspecies communication.

  Molecular microbiology 20031201

• Crystal structures of threonine synthase from Thermus thermophilus HB8: conformational change, substrate recognition, and mechanism.

  The Journal of biological chemistry 20031114

• Interspecies communication in bacteria.

  The Journal of clinical investigation 20031101

• Lsr-mediated transport and processing of AI-2 in Salmonella typhimurium.

  Molecular microbiology 20031101

• The Vibrio fischeri quorum-sensing systems ain and lux sequentially induce luminescence gene expression and are important for persistence in the squid host.

  Molecular microbiology 20031001

• Escherichia coli cystathionine gamma-synthase does not obey ping-pong kinetics. Novel continuous assays for the elimination and substitution reactions.

  Biochemistry 20030930

• In vivo analysis of various substrates utilized by cystathionine gamma-synthase and O-acetylhomoserine sulfhydrylase in methionine biosynthesis.

  Molecular biology and evolution 20030901

• Escherichia coli gets the message.

  Nature medicine 20030901

• Production of acylated homoserine lactones by different serotypes of Vibrio anguillarum both in culture and during infection of rainbow trout.

  Systematic and applied microbiology 20030901

• Constraints on detection of autoinducer-2 (AI-2) signalling molecules using Vibrio harveyi as a reporter.

  Microbiology (Reading, England) 20030801

• Motion to form a quorum.

  Science (New York, N.Y.) 20030711

• Production of the signalling molecule, autoinducer-2, by Neisseria meningitidis: lack of evidence for a concerted transcriptional response.

  Microbiology (Reading, England) 20030701

• Efficient synthesis of enantiopure beta-amino-gamma-keto acids from l-homoserine.

  Organic letters 20030612

• Regulation of Vibrio vulnificus virulence by the LuxS quorum-sensing system.

  Molecular microbiology 20030601

• Library screening for synthetic agonists and antagonists of a Pseudomonas aeruginosa autoinducer.

  Chemistry & biology 20030601

• S-Ribosylhomocysteinase (LuxS) is a mononuclear iron protein.

  Biochemistry 20030429

• LuxS quorum sensing: more than just a numbers game.

  Current opinion in microbiology 20030401

• Autoinducer 2 activity in Escherichia coli culture supernatants can be actively reduced despite maintenance of an active synthase, LuxS.

  Microbiology (Reading, England) 20030301

• Identification and characterization of the new gene rhtA involved in threonine and homoserine efflux in Escherichia coli.

  Research in microbiology 20030301

• Vibrio harveyi quorum sensing: a coincidence detector for two autoinducers controls gene expression.

  The EMBO journal 20030217

• Possible quorum sensing in the rumen microbial community: detection of quorum-sensing signal molecules from rumen bacteria.

  FEMS microbiology letters 20030214

• Synthesis of N-Fmoc-O- (N'-Boc-N'-methyl)-aminohomoserine, an amino acid for the facile preparation of neoglycopeptides.

  The Journal of organic chemistry 20030110

• Solution structure and stability of tryptophan-containing nucleopeptide duplexes.

  Chembiochem : a European journal of chemical biology 20030103

• Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators.

  Journal of medicinal chemistry 20030102

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• LuxS and autoinducer-2: their contribution to quorum sensing and metabolism in bacteria.

  Advances in applied microbiology 20030101

• The role of regulators in the expression of quorum-sensing signals in Pseudomonas aeruginosa.

  Journal of molecular microbiology and biotechnology 20030101

• In vivo aggregation of a single enzyme limits growth of Escherichia coli at elevated temperatures.

  Molecular microbiology 20021201

• A mathematical model of quorum sensing in a growing bacterial biofilm.

  Journal of industrial microbiology & biotechnology 20021201

• Determination of the stoichiometry of noncovalent complexes using reverse-phase high-performance liquid chromatography coupled with electrospray ion trap mass spectrometry.

  Analytical biochemistry 20021001

• Food spoilage--interactions between food spoilage bacteria.

  International journal of food microbiology 20020915

• The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA.

  The EMBO journal 20020902

• The Pseudomonas autoinducer N-(3-oxododecanoyl) homoserine lactone induces cyclooxygenase-2 and prostaglandin E2 production in human lung fibroblasts: implications for inflammation.

  Journal of immunology (Baltimore, Md. : 1950) 20020901

• Crystallization and preliminary X-ray diffraction studies of the transcriptional regulator TraR bound to its cofactor and to a specific DNA sequence.

  Acta crystallographica. Section D, Biological crystallography 20020801

• Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA.

  Nature 20020627

• Quorum sensing: an emerging target for antibacterial chemotherapy?

  Expert opinion on therapeutic targets 20020601

• Can boron get bacteria talking?

  Trends in biochemical sciences 20020501

• Enzymatic assay of gamma-cystathionase activity using pyruvate oxidase-peroxidase sequential reaction.

  Journal of biochemical and biophysical methods 20020418

• Bacterial cell-to-cell communication: sorry, can't talk now - gone to lunch!

  Current opinion in microbiology 20020401

• Cystathionine gamma-synthase and threonine synthase operate in concert to regulate carbon flow towards methionine in plants.

  Trends in plant science 20020401

• [Synthesis of signaling N-acyl-homoserine-lactones participating in quorum sensing in rhizosphere and soil bacteria Pseudomonas and Xanthomonas].

  Genetika 20020401

• L-Homoserine: a novel excreted metabolic marker of hepatitis B abnormally produced in liver from methionine.

  Medical hypotheses 20020401

• Detection of Pseudomonas aeruginosa cell-to-cell signals in lung tissue of cystic fibrosis patients.

  Microbial pathogenesis 20020301

• LuxS-dependent quorum sensing in Porphyromonas gingivalis modulates protease and haemagglutinin activities but is not essential for virulence.

  Microbiology (Reading, England) 20020301

• Detection and mutation of a luxS-encoded autoinducer in Proteus mirabilis.

  Microbiology (Reading, England) 20020301

• A mathematical model of partial-thickness burn-wound infection by Pseudomonas aeruginosa: quorum sensing and the build-up to invasion.

  Bulletin of mathematical biology 20020301

• Function by serendipity.

  Nature 20020131

• Structural identification of a bacterial quorum-sensing signal containing boron.

  Nature 20020131

• Characterization of N-acyl homoserine lactone overproducing mutants of Burkholderia multivorans ATCC 17616.

  FEMS microbiology letters 20020110

• Studies on the production of quorum-sensing signal molecules in Mannheimia haemolytica A1 and other Pasteurellaceae species.

  FEMS microbiology letters 20020102

• New homoserine lipids from Xerocomus langbianensis.

  Journal of basic microbiology 20020101

• N-acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms.

  Microbiology (Reading, England) 20011201

• Quorum signaling via AI-2 communicates the 'Metabolic Burden' associated with heterologous protein production in Escherichia coli.

  Biotechnology and bioengineering 20011120

• Antisense inhibition of threonine synthase leads to high methionine content in transgenic potato plants.

  Plant physiology 20011101

• Mutation of luxS affects growth and virulence factor expression in Streptococcus pyogenes.

  Molecular microbiology 20011001

• Structural basis for the catalysis and substrate specificity of homoserine kinase.

  Biochemistry 20010911

• Haemodynamic effects of the bacterial quorum sensing signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone, in conscious, normal and endotoxaemic rats.

  British journal of pharmacology 20010801

• Phenazine-1-carboxamide production in the biocontrol strain Pseudomonas chlororaphis PCL1391 is regulated by multiple factors secreted into the growth medium.

  Molecular plant-microbe interactions : MPMI 20010801

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  Journal of immunology (Baltimore, Md. : 1950) 20010701

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  International journal of medical microbiology : IJMM 20010501

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