604-59-1 | Alpha-naphthoflavone

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$16.00	$11.00
1g	98%	in stock	$20.00	$14.00
5g	98%	in stock	$41.00	$29.00
25g	98%	in stock	$113.00	$79.00
100g	98%	in stock	$378.00	$265.00

Description

• Catalog Number: AB80521
• Chemical Name: Alpha-naphthoflavone
• CAS Number: 604-59-1
• Molecular Formula: C19H12O2
• Molecular Weight: 272.29738000000003
• MDL Number: MFCD00004985
• SMILES: O=c1cc(oc2c1ccc1c2cccc1)c1ccccc1
• NSC Number: 407011

Computed Properties

• Complexity: 433
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 4.8

Literature

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  Cancer prevention research (Philadelphia, Pa.) 20081101

• A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine.

  Chemico-biological interactions 20081022

• Benzo[a]pyrene induces intercellular adhesion molecule-1 through a caveolae and aryl hydrocarbon receptor mediated pathway.

  Toxicology and applied pharmacology 20081015

• Pharmacokinetics and bioavailability of the flavonoid 7,8-benzoflavone in rats.

  Journal of pharmaceutical sciences 20081001

• Phytotoxic polyacetylenes from roots of Russian knapweed (Acroptilon repens (L.) DC.).

  Phytochemistry 20081001

• Dioxin interferes in chromosomal positioning through the aryl hydrocarbon receptor.

  Biochemical and biophysical research communications 20080919

• A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis.

  Rheumatology (Oxford, England) 20080901

• A low halogenated biphenyl (PCB3) increases CYP1A1 expression and activity via the estrogen receptor beta in the porcine ovary.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080901

• [Effects of cytochrome P450 isozymes on aristolochic acid renal cytotoxicity].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

• Experimental approaches to evaluate activities of cytochromes P450 3A.

  Interdisciplinary toxicology 20080901

• 2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the expression of cKrox and Runx3, transcription regulatory factors controlling the lineage commitment of CD4+CD8+ into CD4 and CD8 thymocytes, respectively.

  Toxicology letters 20080828

• Cigarette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20080801

• Evidence for multiple mechanisms of toxicity in larval rainbow trout (Oncorhynchus mykiss) co-treated with retene and alpha-naphthoflavone.

  Aquatic toxicology (Amsterdam, Netherlands) 20080707

• Genotoxic activation of 2-phenylbenzotriazole-type compounds by human cytochrome P4501A1 and N-acetyltransferase expressed in Salmonella typhimurium umu strains.

  Mutation research 20080630

• Cytochrome P450 2C11 5'-flanking region and promoter: regulation by aromatic hydrocarbons in vitro.

  Toxicology 20080627

• Identification of human liver cytochrome P450 isoforms involved in autoinduced metabolism of the antiangiogenic agent (Z)-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid (TSU-68).

  Drug metabolism and disposition: the biological fate of chemicals 20080601

• Primary peripheral T cells become susceptible to 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated apoptosis in vitro upon activation and in the presence of dendritic cells.

  Molecular pharmacology 20080601

• Spectral resolution of a second binding site for Nile Red on cytochrome P4503A4.

  Archives of biochemistry and biophysics 20080601

• Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis.

  Environmental health perspectives 20080601

• In vitro evaluation of reversible and irreversible cytochrome P450 inhibition: current status on methodologies and their utility for predicting drug-drug interactions.

  The AAPS journal 20080601

• Enhanced TGF-beta1 is involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced oxidative stress in C57BL/6 mouse testis.

  Toxicology letters 20080530

• Effect of troglitazone on CYP1A1 induction.

  Toxicology 20080418

• Biotransformation and pharmacokinetics of the novel anticancer drug, SYUIQ-5, in the rat.

  Investigational new drugs 20080401

• Aminoflavone induces oxidative DNA damage and reactive oxidative species-mediated apoptosis in breast cancer cells.

  International journal of cancer 20080401

• Aryl hydrocarbon receptor mediates laminar fluid shear stress-induced CYP1A1 activation and cell cycle arrest in vascular endothelial cells.

  Cardiovascular research 20080301

• Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein.

  Archives of biochemistry and biophysics 20080301

• Identification of ginkgolide B metabolites in urine and rat liver cytochrome P450 enzymes responsible for their formation in vitro.

  Acta pharmacologica Sinica 20080301

• New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation.

  Bioorganic & medicinal chemistry 20080201

• Significance of prolyl hydroxylase 2 in the interference of aryl hydrocarbon receptor and hypoxia-inducible factor-1 alpha signaling.

  Chemical research in toxicology 20080201

• Identification of cytochrome P450 enzymes involved in the metabolism of the new designer drug 4'-methyl-alpha-pyrrolidinobutyrophenone.

  Drug metabolism and disposition: the biological fate of chemicals 20080101

• Flavonoid treatment of murine macrophages does not alter ingestion or intracellular survival of Listeria monocytogenes.

  Immunopharmacology and immunotoxicology 20080101

• Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes.

  PloS one 20080101

• Cytotoxicity of nitroaromatic explosives and their biodegradation products in mice splenocytes: implications for their immunotoxicity.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20080101

• Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish.

  Aquatic toxicology (Amsterdam, Netherlands) 20071230

• Dioxin affects glucose transport via the arylhydrocarbon receptor signal cascade in pluripotent embryonic carcinoma cells.

  Endocrinology 20071201

• Characterization of a 7,8-benzoflavone double effect on CFTR Cl(-) channel activity.

  The Journal of membrane biology 20071201

• The involvement of secondary signaling molecules in cytochrome P-450 1A1-mediated inducible nitric oxide synthase expression in benzo(a)pyrene-treated rat polymorphonuclear leukocytes.

  Life sciences 20071130

• Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine.

  Drug metabolism and disposition: the biological fate of chemicals 20071101

• Polychlorinated biphenyls 105 and 118 form thyroid hormone receptor agonists after cytochrome P4501A1 activation in rat pituitary GH3 cells.

  Environmental health perspectives 20071101

• Induction of EROD activity by 1-phenylimidazole and beta-naphthoflavone in rainbow trout cultured hepatocytes: a comparative study.

  Toxicology in vitro : an international journal published in association with BIBRA 20071001

• In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors.

  Drug metabolism and disposition: the biological fate of chemicals 20071001

• Polychlorinated biphenyls alter the expression of endothelial nitric oxide synthase mRNA in human umbilical vein endothelial cells.

  Human & experimental toxicology 20071001

• Ligand binding to cytochrome P450 3A4 in phospholipid bilayer nanodiscs: the effect of model membranes.

  The Journal of biological chemistry 20070928

• Signaling pathway for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages.

  Experimental & molecular medicine 20070831

• 2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates functional differentiation of mouse bone marrow-derived dendritic cells Downregulation of RelB by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  Toxicology letters 20070830

• The environmental carcinogen benzo[a]pyrene induces expression of monocyte-chemoattractant protein-1 in vascular tissue: a possible role in atherogenesis.

  Mutation research 20070801

• 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces oxidative stress, DNA strand breaks, and poly(ADP-ribose) polymerase-1 activation in human breast carcinoma cell lines.

  Toxicology letters 20070801

• Energetics of heterotropic cooperativity between alpha-naphthoflavone and testosterone binding to CYP3A4.

  Archives of biochemistry and biophysics 20070701

• Involvement of human cytochrome P450 2B6 in the omega- and 4-hydroxylation of the anesthetic agent propofol.

  Xenobiotica; the fate of foreign compounds in biological systems 20070701

• Abundance of aryl hydrocarbon receptor potentiates benzo[a]pyrene-induced apoptosis in Hepa1c1c7 cells via CYP1A1 activation.

  Toxicology 20070603

• Autoradiographic localization of aromatic hydrocarbon receptor (AHR) in rhesus monkey ovary.

  American journal of primatology 20070601

• [Simultaneous determination of the inhibitory potency of compounds on the activity of five cytochrome P-450 enzymes using a cocktail probe substrates method].

  Yao xue xue bao = Acta pharmaceutica Sinica 20070601

• Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2.

  The Journal of biological chemistry 20070511

• Human cytochrome p450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes.

  Chemical research in toxicology 20070501

• TCDD alters PKC signaling pathways in developing neuronal cells in culture.

  Chemosphere 20070401

• Expression of zebra fish aromatase cyp19a and cyp19b genes in response to the ligands of estrogen receptor and aryl hydrocarbon receptor.

  Toxicological sciences : an official journal of the Society of Toxicology 20070401

• 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure of normal human dermal fibroblasts results in AhR-dependent and -independent changes in gene expression.

  Toxicology and applied pharmacology 20070401

• Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W.

  Archives of biochemistry and biophysics 20070401

• Genistein inhibits glutamate-induced apoptotic processes in primary neuronal cell cultures: an involvement of aryl hydrocarbon receptor and estrogen receptor/glycogen synthase kinase-3beta intracellular signaling pathway.

  Neuroscience 20070316

• Inhibition of CYP1A enzymes by alpha-naphthoflavone causes both synergism and antagonism of retene toxicity to rainbow trout (Oncorhynchus mykiss).

  Aquatic toxicology (Amsterdam, Netherlands) 20070310

• Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: possible implications for their mutagenic and carcinogenic effects.

  Toxicology 20070307

• Translocation of PKC-betaII is mediated via RACK-1 in the neuronal cells following dioxin exposure.

  Neurotoxicology 20070301

• Polycyclic aromatic hydrocarbon (PAH) metabolizing enzyme activities in human lung, and their inducibility by exposure to naphthalene, phenanthrene, pyrene, chrysene, and benzo(a)pyrene as shown in the rat lung and liver.

  Archives of toxicology 20070301

• Involvement of CYP2A6 in the formation of a novel metabolite, 3-hydroxypilocarpine, from pilocarpine in human liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20070301

• Targeted salmon gene array (SalArray): a toxicogenomic tool for gene expression profiling of interactions between estrogen and aryl hydrocarbon receptor signalling pathways.

  Chemical research in toxicology 20070301

• Potential cancer chemopreventive in vitro activities of monomeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis.

  Journal of natural products 20070301

• Benzo(a)pyrene inhibits growth and functional differentiation of mouse bone marrow-derived dendritic cells. Downregulation of RelB and eIF3 p170 by benzo(a)pyrene.

  Toxicology letters 20070227

• Dissecting the thermodynamics and cooperativity of ligand binding in cytochrome P450eryF.

  Journal of the American Chemical Society 20070221

• Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe.

  Biochemistry 20070109

• Role of dioxin response element and nuclear factor-kappaB motifs in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated regulation of Fas and Fas ligand expression.

  Molecular pharmacology 20070101

• CYP3A4 mediated in vitro metabolism of vinflunine in human liver microsomes.

  Acta pharmacologica Sinica 20070101

• Effect of cytochrome P450 (CYP) inducers on caffeine metabolism in the rat.

  Pharmacological reports : PR 20070101

• Antiteratogenic effects of alpha-naphthoflavone on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposed mice in utero.

  Reproductive toxicology (Elmsford, N.Y.) 20070101

• Suppression of T lymphocyte proliferation to antigenic and mitogenic stimuli by Benzo(alpha)pyrene and 2-aminofluorene metabolites.

  Immunopharmacology and immunotoxicology 20070101

• Is PPARbeta/delta a Retinoid Receptor?

  PPAR research 20070101

• The effect of aryl hydrocarbon receptor ligands on the expression of AhR, AhRR, ARNT, Hif1alpha, CYP1A1 and NQO1 genes in rat liver.

  Toxicology letters 20061215

• Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

  Journal of molecular graphics & modelling 20061101

• Elucidation of the effects of the CYP1A2 deficiency polymorphism in the metabolism of 4-cyclohexyl-1-ethyl-7-methylpyrido[2,3-d]pyrimidine-2-(1h)-one (YM-64227), a phosphodiesterase type 4 inhibitor, and its metabolites in dogs.

  Drug metabolism and disposition: the biological fate of chemicals 20061101

• Regioselective 2-hydroxylation of 17beta-estradiol by rat cytochrome P4501B1.

  Toxicology and applied pharmacology 20061101

• OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice.

  PLoS medicine 20061101

• Estrogen receptor alpha as a target for indole-3-carbinol.

  The Journal of nutritional biochemistry 20061001

• Characterization of CYP1A enzyme in Adélie penguin liver.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20061001

• Metabolism and metabolic inhibition of gambogic acid in rat liver microsomes.

  Acta pharmacologica Sinica 20060901

• Induction of ROS formation, poly(ADP-ribose) polymerase-1 activation, and cell death by PCB126 and PCB153 in human T47D and MDA-MB-231 breast cancer cells.

  Chemico-biological interactions 20060825

• Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3.

  Biochemical and biophysical research communications 20060804

• The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish.

  Toxicological sciences : an official journal of the Society of Toxicology 20060801

• Effect of cytochromes P450 chemical inhibitors and monoclonal antibodies on human liver microsomal esterase activity.

  Drug metabolism and disposition: the biological fate of chemicals 20060801

• Induction of the transferrin receptor gene by benzo[a]pyrene in breast cancer MCF-7 cells: potential as a biomarker of PAH exposure.

  Environmental and molecular mutagenesis 20060801

• Induction of propranolol metabolism by Ginkgo biloba extract EGb 761 in rats.

  Current drug metabolism 20060801

• Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene.

  The Journal of biological chemistry 20060721

• Naturally occurring coumarins inhibit 7,12-dimethylbenz[a]anthracene DNA adduct formation in mouse mammary gland.

  Carcinogenesis 20060601

• Demethylation of the pesticide methoxychlor in liver and intestine from untreated, methoxychlor-treated, and 3-methylcholanthrene-treated channel catfish (Ictalurus punctatus): evidence for roles of CYP1 and CYP3A family isozymes.

  Drug metabolism and disposition: the biological fate of chemicals 20060601

• Involvement of endogenous nitric oxide in myeloperoxidase mediated benzo(a)pyrene induced polymorphonuclear leukocytes injury.

  Molecular and cellular biochemistry 20060601

• Effect of some carcinogenic and non-carcinogenic polycyclic aromatic hydrocarbons on gap junction intercellular communication in hepatoma cell cultures.

  European journal of cell biology 20060501

• Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines.

  Bioorganic & medicinal chemistry 20060501

• Oxidative metabolism of the alkaloid rutaecarpine by human cytochrome P450.

  Drug metabolism and disposition: the biological fate of chemicals 20060501

• Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4.

  The Journal of biological chemistry 20060407

• Formation of 4'-carboxyl acid metabolite of imrecoxib by rat liver microsomes.

  Acta pharmacologica Sinica 20060401

• Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine.

  Nuclear medicine and biology 20060401

• Preferential inducibility of CYP1A1 and CYP1A2 by TCDD: differential regulation in primary human hepatocytes versus transformed human cells.

  Biochemical and biophysical research communications 20060310

• Role of rat liver cytochrome P450 3A and 2D in metabolism of imrecoxib.

  Acta pharmacologica Sinica 20060301

• The ligand status of the aromatic hydrocarbon receptor modulates transcriptional activation of BRCA-1 promoter by estrogen.

  Cancer research 20060215

• An aryl hydrocarbon receptor agonist amplifies the mitogenic actions of estradiol in granulosa cells: evidence of involvement of the cognate receptors.

  Biology of reproduction 20060201

• Characterization of anti-apoptotic action of TCDD as a defensive cellular stress response reaction against the cell damaging action of ultra-violet irradiation in an immortalized normal human mammary epithelial cell line, MCF10A.

  Toxicology 20060116

• Effects of endocrine disrupters on the expression of growth hormone and prolactin mRNA in the rainbow trout pituitary.

  General and comparative endocrinology 20060115

• Antiproliferative and antiangiogenic effects of 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, in human umbilical vascular endothelial cells.

  European journal of pharmacology 20060113

• Molecular cloning and expression of a novel cytochrome p450 from turkey liver with aflatoxin b1 oxidizing activity.

  Chemical research in toxicology 20060101

• Human cytochrome p450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol.

  Chemical research in toxicology 20060101

• Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A.

  Breast cancer research : BCR 20060101

• Enzymatic characteristics of CYP3A5 and CYP3A4: a comparison of in vitro kinetic and drug-drug interaction patterns.

  Xenobiotica; the fate of foreign compounds in biological systems 20060101

• Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SK-HEP-1 to dioxin.

  Toxicology letters 20051230

• Modulation of human cytochrome P450 1B1 expression by 2,4,3',5'-tetramethoxystilbene.

  Drug metabolism and disposition: the biological fate of chemicals 20051201

• CYP1A1-mediated mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons.

  Biochemical and biophysical research communications 20051118

• Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study.

  Biochemistry 20051101

• Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.

  Current drug metabolism 20051001

• The spectrum of enzymes involved in activation of 2-aminoanthracene varies with the metabolic system applied.

  Mutation research 20050905

• Human CD34-positive hematopoietic stem cells constitute targets for carcinogenic polycyclic aromatic hydrocarbons.

  The Journal of pharmacology and experimental therapeutics 20050801

• Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20050801

• Metabolism of the alpha,beta-unsaturated ketones, chalcone and trans-4-phenyl-3-buten-2-one, by rat liver microsomes and estrogenic activity of the metabolites.

  Drug metabolism and disposition: the biological fate of chemicals 20050801

• Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity.

  Drug metabolism and disposition: the biological fate of chemicals 20050801

• CYP1A1 and CYP1B1 expressions in medulloblastoma cells are AhR-independent and have no direct link with resveratrol-induced differentiation and apoptosis.

  Neuroscience letters 20050801

• Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography.

  Journal of biomolecular screening 20050801

• TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway.

  Oncogene 20050721

• The effects of 3-methylcholanthrene on lymphocyte proliferation in the common carp (Cyprinus carpio L.).

  Toxicology 20050701

• Tobacco smoke stimulates the transcription of amphiregulin in human oral epithelial cells: evidence of a cyclic AMP-responsive element binding protein-dependent mechanism.

  Cancer research 20050701

• alpha-Naphthoflavone, a potent antiplatelet flavonoid, is mediated through inhibition of phospholipase C activity and stimulation of cyclic GMP formation.

  Journal of agricultural and food chemistry 20050629

• Altered expression of cytochrome P450 and possible correlation with preneoplastic changes in early stage of rat hepatocarcinogenesis.

  Acta pharmacologica Sinica 20050601

• Properties and regional expression of a CYP3A-like protein in channel catfish intestine.

  Aquatic toxicology (Amsterdam, Netherlands) 20050515

• Intestinal metabolism of PAH: in vitro demonstration and study of its impact on PAH transfer through the intestinal epithelium.

  Environmental research 20050501

• Modulation of Ah receptor and CYP1A1 expression by alpha-naphthoflavone in rainbow trout hepatocytes.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20050501

• Molecular mechanism of the aryl hydrocarbon receptor activation by the fungicide iprodione in rainbow trout (Oncorhynchus mykiss) hepatocytes.

  Aquatic toxicology (Amsterdam, Netherlands) 20050430

• Effects of 3-methylcholanthrene on the transcriptional activity and mRNA accumulation of the oncogene hWAPL.

  Cancer letters 20050418

• Ah Receptor-mediated impairment of interrenal steroidogenesis involves StAR protein and P450scc gene attenuation in rainbow trout.

  Toxicological sciences : an official journal of the Society of Toxicology 20050401

• Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice.

  Drug metabolism and disposition: the biological fate of chemicals 20050301

• Chemoprotective and toxic potentials of synthetic and natural chalcones and dihydrochalcones in vitro.

  Toxicology 20050301

• Differences between rats and mice in the involvement of the aryl hydrocarbon receptor in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss.

  Toxicology and applied pharmacology 20050301

• Bisindigotin, a TCDD antagonist from the Chinese medicinal herb Isatis indigotica.

  Journal of natural products 20050301

• Molecular cloning and functional analysis of cytochrome P450 1A2 from Japanese monkey liver: comparison with marmoset cytochrome P450 1A2.

  Chemico-biological interactions 20050227

• CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis.

  The Journal of clinical endocrinology and metabolism 20050201

• Effects of TCDD and estradiol-17beta on the proliferation and Na+/glucose cotransporter in renal proximal tubule cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20050201

• Fast-track DRESSA: a bioassay for fast, sensitive, and selective detection of halogenated and polycyclic aromatic hydrocarbons.

  Analytical biochemistry 20050201

• A microtiterplate-based screening assay to assess diverse effects on cytochrome P450 enzyme activities in primary rat hepatocytes by various compounds.

  Assay and drug development technologies 20050201

• Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.

  Journal of medicinal chemistry 20050127

• Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites.

  Chemico-biological interactions 20050115

• TCDD activates Mdm2 and attenuates the p53 response to DNA damaging agents.

  Carcinogenesis 20050101

• Cytochromes 1A1/1B1- and catechol-O-methyltransferase-derived metabolites mediate estradiol-induced antimitogenesis in human cardiac fibroblast.

  The Journal of clinical endocrinology and metabolism 20050101

• Induction of cytochrome P4501A (CYP1A) by clotrimazole, a non-planar aromatic compound. Computational studies on structural features of clotrimazole and related imidazole derivatives.

  Life sciences 20041224

• Effects of polybrominated diphenyl ethers on basal and TCDD-induced ethoxyresorufin activity and cytochrome P450-1A1 expression in MCF-7, HepG2, and H4IIE cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20041201

• Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus.

  Environmental health perspectives 20041201

• Expression of the arylhydrocarbon receptor in the peri-implantation period of the mouse uterus and the impact of dioxin on mouse implantation.

  Archives of histology and cytology 20041201

• Benzo[a]pyrene-induced immunotoxicity in Japanese medaka (Oryzias latipes): relationship between lymphoid CYP1A activity and humoral immune suppression.

  Toxicology and applied pharmacology 20041115

• Roles of reactive oxygen species and heme oxygenase-1 in modulation of alveolar macrophage-mediated pulmonary immune responses to Listeria monocytogenes by diesel exhaust particles.

  Toxicological sciences : an official journal of the Society of Toxicology 20041101

• Superinduction of CYP1A1 in MCF10A cultures by cycloheximide, anisomycin, and puromycin: a process independent of effects on protein translation and unrelated to suppression of aryl hydrocarbon receptor proteolysis by the proteasome.

  Molecular pharmacology 20041001

• Disruption of cell-cell contact maximally but transiently activates AhR-mediated transcription in 10T1/2 fibroblasts.

  Toxicology and applied pharmacology 20040915

• TCDD-induced homologous recombination: the role of the Ah receptor versus oxidative DNA damage.

  Mutation research 20040912

• TCDD affects DNA double strand-break repair.

  Toxicological sciences : an official journal of the Society of Toxicology 20040901

• Cytochrome P450 CYP1B1 activity in renal cell carcinoma.

  British journal of cancer 20040831

• Drug-drug interactions of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338.

  European journal of pharmacology 20040823

• Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes.

  Biochemical pharmacology 20040815

• 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: evidence for activation by cytochrome P450 1A1 and P450 1A2.

  Chemical research in toxicology 20040801

• Specific interactions of steroids, arylhydrocarbons and flavonoids with progesterone receptors from the cytosol of the fungus Rhizopus nigricans.

  The Journal of steroid biochemistry and molecular biology 20040801

• Influence of selected inhibitors on the metabolism of the styrene metabolite 4-vinylphenol in wild-type and CYP2E1 knockout mice.

  Journal of toxicology and environmental health. Part A 20040625

• Induction of metallothionein I by phenolic antioxidants requires metal-activated transcription factor 1 (MTF-1) and zinc.

  The Biochemical journal 20040615

• Interaction between the aryl hydrocarbon receptor and retinoic acid pathways increases matrix metalloproteinase-1 expression in keratinocytes.

  The Journal of biological chemistry 20040611

• 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits cell proliferation through arylhydrocarbon receptor-mediated G1 arrest in SK-N-SH human neuronal cells.

  Neuroscience letters 20040603

• Cytochrome P450-dependent toxicity of environmental polycyclic aromatic hydrocarbons towards human macrophages.

  Biochemical and biophysical research communications 20040507

• Polycyclic aromatic hydrocarbons induce both apoptotic and anti-apoptotic signals in Hepa1c1c7 cells.

  Carcinogenesis 20040501

• The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20040501

• Benzo[a]pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenase-2 pathway.

  Chemical research in toxicology 20040501

• Retionic acid and its receptors are required for expression of aryl hydrocarbon receptor mRNA and embryonic development of blood vessel and bone in the medaka fish, Oryzias latipes.

  Zoological science 20040501

• Antiestrogenic effects of motorcycle exhaust particulate in MCF-7 human breast cancer cells and immature female rats.

  Archives of environmental contamination and toxicology 20040501

• beta-Naphthoflavone disrupts cortisol production and liver glucocorticoid responsiveness in rainbow trout.

  Aquatic toxicology (Amsterdam, Netherlands) 20040428

• Reduction of androgen receptor expression by benzo[alpha]pyrene and 7,8-dihydro-9,10-epoxy-7,8,9,10-tetrahydrobenzo[alpha]pyrene in human lung cells.

  Biochemical pharmacology 20040415

• Constitutive expression of CYP1A1 in bovine cumulus oocyte-complexes in vitro: mechanisms and biological implications.

  Endocrinology 20040401

• CYP3A4 is a human microsomal vitamin D 25-hydroxylase.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040401

• MAPK signaling pathways modulate IL-1beta expression in human keratinocytes.

  Archives of biochemistry and biophysics 20040401

• Induction of diphenytriazol on cytochrome CYP1A.

  Acta pharmacologica Sinica 20040401

• Polycyclic aromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor.

  Biological & pharmaceutical bulletin 20040301

• 3-Methylcholanthrene induces lymphocyte and phagocyte apoptosis in common carp (Cyprinus carpio L) in vitro.

  Aquatic toxicology (Amsterdam, Netherlands) 20040225

• A comparative study on the effects of 2,3,7,8,-tetrachlorodibenzo-p-dioxin polychlorinated biphenyl126 and estrogen in human bronchial epithelial cells.

  Toxicology and applied pharmacology 20040215

• Aryl hydrocarbon receptor-mediated posttranscriptional regulation of IL-1beta.

  Archives of biochemistry and biophysics 20040201

• Polymorphic expression of CYP1A2 leading to interindividual variability in metabolism of a novel benzodiazepine receptor partial inverse agonist in dogs.

  Drug metabolism and disposition: the biological fate of chemicals 20040201

• Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes.

  The Journal of pharmacy and pharmacology 20040201

• Biphasic effects of the flavonoids quercetin and naringenin on the metabolic activation of 2-amino-3,5-dimethylimidazo[4,5-f]quinoline by Salmonella typhimurium TA1538 co-expressing human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and cytochrome b5.

  Mutation research 20040112

• Antiproliferative activity of various flavonoids and related compounds: additive effect of interferon-alpha2b.

  Bioorganic & medicinal chemistry letters 20040105

• An assessment of udp-glucuronosyltransferase induction using primary human hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20040101

• Cytochrome P450 1A1 (CYP1A1) inhibitor alpha-naphthoflavone interferes with UDP-glucuronosyltransferase (UGT) activity in intact but not in permeabilized hepatic microsomes from 3-methylcholanthrene-treated rats: possible involvement of UGT-P450 interactions.

  Biological & pharmaceutical bulletin 20040101

• Differential oxidant potential of carcinogenic and weakly carcinogenic estrogens: Involvement of metabolic activation and cytochrome P450.

  Journal of biochemical and molecular toxicology 20040101

• Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors.

  Marine environmental research 20040101

• Suppressive effects of benzo[a]pyrene upon fish immune function: evolutionarily conserved cellular mechanisms of immunotoxicity.

  Marine environmental research 20040101

• Antiandrogenic activities of diesel exhaust particle extracts in PC3/AR human prostate carcinoma cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20031201

• Bone marrow stromal-B cell interactions in polycyclic aromatic hydrocarbon-induced pro/pre-B cell apoptosis.

  Toxicological sciences : an official journal of the Society of Toxicology 20031201

• Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20031101

• Alpha-naphthoflavone induces vasorelaxation through the induction of extracellular calcium influx and NO formation in endothelium.

  Naunyn-Schmiedeberg's archives of pharmacology 20031101

• Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain.

  Bioorganic & medicinal chemistry 20030901

• 7,8-Benzoflavone: a phytotoxin from root exudates of invasive Russian knapweed.

  Phytochemistry 20030901

• Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes.

  European journal of biochemistry 20030901

• Rabbit CYP4B1 engineered for high-level expression in Escherichia coli: ligand stabilization and processing of the N-terminus and heme prosthetic group.

  Archives of biochemistry and biophysics 20030801

• 3'-methoxy-4'-nitroflavone, a reported aryl hydrocarbon receptor antagonist, enhances Cyp1a1 transcription by a dioxin responsive element-dependent mechanism.

  Archives of biochemistry and biophysics 20030801

• CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds.

  American journal of physiology. Lung cellular and molecular physiology 20030701

• Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation.

  Drug metabolism and disposition: the biological fate of chemicals 20030701

• In vitro activation of 7-benzyloxyresorufin O-debenzylation and nifedipine oxidation in human liver microsomes.

  Xenobiotica; the fate of foreign compounds in biological systems 20030701

• Molecular modelling of human CYP1B1 substrate interactions and investigation of allelic variant effects on metabolism.

  Chemico-biological interactions 20030615

• Preclinical factors affecting the interindividual variability in the clearance of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid.

  Biochemical pharmacology 20030601

• A role of aryl hydrocarbon receptor in the antiandrogenic effects of polycyclic aromatic hydrocarbons in LNCaP human prostate carcinoma cells.

  Archives of toxicology 20030601

• In vitro inhibition of human small intestinal and liver microsomal astemizole O-demethylation: different contribution of CYP2J2 in the small intestine and liver.

  Xenobiotica; the fate of foreign compounds in biological systems 20030601

• Tight-binding inhibition by alpha-naphthoflavone of human cytochrome P450 1A2.

  Biochimica et biophysica acta 20030530

• Cytochrome P450 expression and testosterone metabolism in the liver of deer.

  Toxicology 20030501

• Frequency of SCEs in Japanese infants exposed to dioxins and PCBs through the breast milk.

  Fukuoka igaku zasshi = Hukuoka acta medica 20030501

• Frequency of SCEs in Japanese infants lactationally exposed to organochlorone pesticides.

  Fukuoka igaku zasshi = Hukuoka acta medica 20030501

• Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study.

  Drug metabolism and disposition: the biological fate of chemicals 20030401

• CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids.

  Drug metabolism and disposition: the biological fate of chemicals 20030401

• Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements.

  Molecular pharmacology 20030401

• Induction of CYP1A by the N-imidazole derivative, 1-benzylimidazole.

  Environmental toxicology and chemistry 20030401

• A study on CYP1A inhibitory action of E-2-(4'-methoxybenzylidene)-1-benzosuberone and some related chalcones and cyclic chalcone analogues.

  Toxicology 20030303

• Polycyclic aromatic hydrocarbons inhibit differentiation of human monocytes into macrophages.

  Journal of immunology (Baltimore, Md. : 1950) 20030301

• Metabolism and metabolic inhibition of cilnidipine in human liver microsomes.

  Acta pharmacologica Sinica 20030301

• CYP450- and COMT-derived estradiol metabolites inhibit activity of human coronary artery SMCs.

  Hypertension (Dallas, Tex. : 1979) 20030301

• Flavonoid modulation of ionic currents mediated by GABA(A) and GABA(C) receptors.

  European journal of pharmacology 20030214

• In vitro metabolism of fenthion and fenthion sulfoxide by liver preparations of sea bream, goldfish, and rats.

  Drug metabolism and disposition: the biological fate of chemicals 20030201

• Aryl hydrocarbon receptor ligands repress T-cadherin expression in vascular smooth muscle cells.

  Biochemical and biophysical research communications 20030124

• Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites.

  Chemico-biological interactions 20030106

• The presence of inducible cytochrome P450 types 1A1 and 1A2 in the BeWo cell line.

  Placenta 20030101

• Role of specific cytochrome P450 enzymes in the N-oxidation of the antiarrhythmic agent mexiletine.

  Xenobiotica; the fate of foreign compounds in biological systems 20030101

• Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes.

  Xenobiotica; the fate of foreign compounds in biological systems 20030101

• Mutagenic activation of arylamines by subcellular fractions of Chamaelea gallina clams exposed to environmental pollutants.

  Environmental and molecular mutagenesis 20030101

• Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies.

  Mutation research 20030101

• Inhibition of the microsomal metabolism of 1,8-cineole in the common brushtail possum (Trichosurus vulpecula) by terpenes and other chemicals.

  Xenobiotica; the fate of foreign compounds in biological systems 20021201

• Docetaxel (Taxotere) is not metabolized by recombinant human CYP1B1 in vitro, but acts as an effector of this isozyme.

  Drug metabolism and disposition: the biological fate of chemicals 20021101

• Overexpression of the aryl hydrocarbon receptor (AhR) accelerates the cell proliferation of A549 cells.

  Journal of biochemistry 20021101

• Induction of cytochrome P4501A1 by autoclavable culture medium change in HepG2 cells.

  Xenobiotica; the fate of foreign compounds in biological systems 20021101

• The contribution of cytochrome P-450 isoenzymes to the metabolism of phenothiazine neuroleptics.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20021001

• Pituitary adenylate cyclase-activating polypeptide induces a sustained increase in intracellular free Ca(2+) concentration and catechol amine release by activating Ca(2+) influx via receptor-stimulated Ca(2+) entry, independent of store-operated Ca(2+) channels, and voltage-dependent Ca(2+) channels in bovine adrenal medullary chromaffin cells.

  The Journal of pharmacology and experimental therapeutics 20020901

• 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: local circulation failure in the dorsal midbrain is associated with increased apoptosis.

  Toxicological sciences : an official journal of the Society of Toxicology 20020901

• Characterization of human CYP1A1/1A2 induction by DNA microarray and alpha-naphthoflavone.

  Biochemical and biophysical research communications 20020809

• Resistance of MCF-7 cells to dimethylbenz(a)anthracene-induced apoptosis is due to reduced CYP1A1 expression.

  International journal of oncology 20020801

• Apoptosis in murine hepatoma hepa 1c1c7 wild-type, C12, and C4 cells mediated by bilirubin.

  Molecular pharmacology 20020801

• Target cells for cytochrome p450-catalysed irreversible binding of 7,12-dimethylbenz[a]anthracene (DMBA) in rodent adrenal glands.

  Archives of toxicology 20020801

• Membrane-bound progesterone receptors coupled to G proteins in the fungus Rhizopus nigricans.

  FEMS microbiology letters 20020716

• Estradiol enhances and estriol inhibits the expression of CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in a mouse ovarian cancer cell line.

  Toxicology 20020715

• Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2.

  Molecular pharmacology 20020701

• 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces plasminogen activator inhibitor-1 through an aryl hydrocarbon receptor-mediated pathway in mouse hepatoma cell lines.

  Archives of toxicology 20020701

• 4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine.

  The Journal of pharmacology and experimental therapeutics 20020601

• Polychlorinated biphenyl-induced apoptosis of murine spleen cells is aryl hydrocarbon receptor independent but caspases dependent.

  Toxicology and applied pharmacology 20020601

• Aryl hydrocarbon receptor-dependent inhibition of AP-1 activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin in activated B cells.

  Toxicology and applied pharmacology 20020601

• Thalidomide metabolism by the CYP2C subfamily.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020601

• 7-Benzyloxyquinoline oxidation by P450eryF A245T: finding of a new fluorescent substrate probe.

  Chemical research in toxicology 20020601

• In vitro metabolic characteristics of cytochrome P-450 2A6 in Chinese liver microsomes.

  Acta pharmacologica Sinica 20020501

• Benzo(a)pyrene exposure induces CYP1A1 activity and expression in human endometrial cells.

  The Journal of steroid biochemistry and molecular biology 20020501

• Acute cytotoxicity of the chemical carcinogen 2-acetylaminofluorene in cultured rat liver epithelial cells.

  Toxicology letters 20020328

• Cytochrome P450 1A1/2 mediated metabolism of trans-stilbene in rats and humans.

  Biological & pharmaceutical bulletin 20020301

• Aryl hydrocarbon receptor is required for prevention of blood clotting and for the development of vasculature and bone in the embryos of medaka fish, Oryzias latipes.

  Zoological science 20020301

• Regio-specific hydroxylation of nonylphenol and the involvement of CYP2K- and CYP2M-like iso-enzymes in Atlantic salmon (Salmo salar).

  Aquatic toxicology (Amsterdam, Netherlands) 20020201

• Ligand activation of the aromatic hydrocarbon receptor transcription factor drives Bax-dependent apoptosis in developing fetal ovarian germ cells.

  Endocrinology 20020201

• Role of cytochrome P450 1a1 and 1b1 in the metabolic activation of 7,12-dimethylbenz[a]anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation.

  Chemical research in toxicology 20020201

• Increase of CYP1B1 transcription in human keratinocytes and HaCaT cells after UV-B exposure.

  Toxicology and applied pharmacology 20020201

• CYP1A-mediated metabolism of the Janus kinase-3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: structural basis for inactivation by regioselective O-demethylation.

  Drug metabolism and disposition: the biological fate of chemicals 20020101

• Comparative aflatoxin B(1) activation and cytotoxicity in human bronchial cells expressing cytochromes P450 1A2 and 3A4.

  Cancer research 20020101

• Epigenetics of breast cancer: polycyclic aromatic hydrocarbons as risk factors.

  Environmental and molecular mutagenesis 20020101

• The Japanese medaka (Oryzias latipes) model: applicability for investigating the immunosuppressive effects of the aquatic pollutant benzo[a]pyrene (BaP).

  Marine environmental research 20020101

• Kinetic analysis for multiple substrate interaction at the active site of cytochrome P450.

  Methods in enzymology 20020101

• Presence on human chromosome 10 of omeprazole-sensitivity gene whose product mediates CYP1A1 induction.

  Cytogenetic and genome research 20020101

• A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction.

  Journal of pharmacological and toxicological methods 20020101

• Comparative analysis of in vitro and in vivo pharmacokinetic parameters related to individual variability of GTS-21 in canine.

  Drug metabolism and pharmacokinetics 20020101

• Estrogen-mediated suppression of cytochrome P4501A (CYP1A) expression in rainbow trout hepatocytes: role of estrogen receptor.

  Chemico-biological interactions 20011221

• Induction by xenobiotics of phase I and phase II enzyme activities in the human keratinocyte cell line NCTC 2544.

  Toxicology in vitro : an international journal published in association with BIBRA 20011201

• The influence of diesel exhaust particles on mononuclear phagocytic cell-derived cytokines: IL-10, TGF-beta and IL-1 beta.

  Clinical and experimental immunology 20011201

• Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slices.

  Journal of pineal research 20011101

• alpha-Naphthoflavone acts as activator and reversible or irreversible inhibitor of rabbit microsomal CYP3A6.

  Chemico-biological interactions 20011025

• Aryl hydrocarbon receptor/dioxin receptor in human monocytes and macrophages.

  Molecular and cellular biochemistry 20011001

• Constitutive and inducible expression of Cyp1a1 and Cyp1b1 in vascular smooth muscle cells: role of the Ahr bHLH/PAS transcription factor.

  Circulation research 20010928

• Transient expression of CYP1A1 in rat epithelial cells cultured in suspension.

  Archives of biochemistry and biophysics 20010901

• A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver.

  Biochemical pharmacology 20010901

• Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity.

  Biochemistry 20010828

• Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2.

  Chemical research in toxicology 20010801

• Intestinal first-pass metabolism of eperisone in the rat.

  Pharmaceutical research 20010801

• Cytochrome P450 CYP1B1 protein expression: a novel mechanism of anticancer drug resistance.

  Biochemical pharmacology 20010715

• In vitro metabolism of 14C-moxidectin by hepatic microsomes from various species.

  Veterinary research communications 20010701

• Cytochrome P450 1A1 (CYP1A1) in blood lymphocytes evidence for catalytic activity and mRNA expression.

  Life sciences 20010615

• Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds.

  The Journal of biological chemistry 20010608

• Metabolism of DHEA by cytochromes P450 in rat and human liver microsomal fractions.

  Archives of biochemistry and biophysics 20010515

• Inhibitory effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cAMP-induced differentiation of rat C6 glial cell line.

  Journal of neuroscience research 20010515

• 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin induces apoptosis in the dorsal midbrain of zebrafish embryos by activation of arylhydrocarbon receptor.

  Neuroscience letters 20010511

• Effect of dioxins in mother's milk on sister chromatid exchange frequency in infant lymphocytes.

  Fukuoka igaku zasshi = Hukuoka acta medica 20010501

• Metabolism of amiodarone (Part III): identification of rabbit cytochrome P450 isoforms involved in the hydroxylation of mono-N-desethylamiodarone.

  Xenobiotica; the fate of foreign compounds in biological systems 20010501

• Cooperativity of alpha-naphthoflavone in cytochrome P450 3A-dependent drug oxidation activities in hepatic and intestinal microsomes from mouse and human.

  Xenobiotica; the fate of foreign compounds in biological systems 20010501

• Influence of ligand binding to human cytochrome P-450 1A2: conformational activation and stabilization by alpha-naphthoflavone.

  Biochimica et biophysica acta 20010407

• Effects of multiple exposures of small doses of Pembina Cardium crude oil and diesel in rats.

  Archives of environmental contamination and toxicology 20010401

• Protection against nitrofurantoin-induced oxidative stress by coelenterazine analogues and their oxidation products in rat hepatocytes.

  Free radical research 20010301

• Characterization of (+/-)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6.

  Pharmacogenetics 20010301

• Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition.

  Molecular and cellular endocrinology 20010214

• CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.

  Drug metabolism and disposition: the biological fate of chemicals 20010201

• Induction of 7-ethoxyresorufin-O-deethylase activity by planar chlorinated hydrocarbons and polycyclic aromatic hydrocarbons in cell lines from the rainbow trout pituitary.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20010201

• High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. V. Validation of a direct injection/on-line guard cartridge extraction--tandem mass spectrometry method for CYP1A2 inhibition assessment.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010201

• A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4.

  The Journal of biological chemistry 20010119

• Induction of apoptosis in human lymphocytes by the herbicide 2,4-dichlorophenoxyacetic acid.

  Human immunology 20010101

• Characterization of xenobiotic-metabolizing cytochrome P450 (CYP) forms in ringed and grey seals from the Baltic Sea and reference sites.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20010101

• Application of the ethoxyresorufin-O-deethylase (EROD) assay to mixtures of halogenated aromatic compounds.

  Environmental toxicology 20010101

• Cytochrome P450 1A expression in midwater fishes: potential effects of chemical contaminants in remote oceanic zones.

  Environmental science & technology 20010101

• Effects of donor age and contamination level of dioxins and related chemicals on frequency of sister chromatid exchanges in human lymphocytes cultured in vitro.

  Chemosphere 20010101

• Comparison between 'Yusho' patients and healthy Japanese in contamination level of dioxins and related chemicals and frequency of sister chromatid exchanges.

  Chemosphere 20010101

• Steroid hormone activity of flavonoids and related compounds.

  Breast cancer research and treatment 20000701

• Metabolism of 3-methylindole by porcine liver microsomes: responsible cytochrome P450 enzymes.

  Toxicological sciences : an official journal of the Society of Toxicology 20000601

• A novel 4 S [3H]beta-naphthoflavone-binding protein in liver cytosol of female Sprague-Dawley rats treated with aryl hydrocarbon receptor agonists.

  The Biochemical journal 20000501

• The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1.

  Archives of biochemistry and biophysics 20000101

• Induction of CYP1A by carbofuran in primary culture of fish hepatocytes.

  Journal of biochemical and molecular toxicology 20000101

• Priming effect of benzo[a]pyrene on monocyte oxidative metabolism: possible mechanisms.

  Toxicology letters 19991029

• Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity.

  Molecular pharmacology 19991001

• Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition.

  Molecular endocrinology (Baltimore, Md.) 19990901

• Suppression of cell cycle progression by flavonoids: dependence on the aryl hydrocarbon receptor.

  Carcinogenesis 19990801

• Differential regulation of c-fos expression in estrogen-induced hamster renal tumors compared with kidney not due to creation of an estrogen-response element by point mutation in the gene's flanking sequence.

  Molecular carcinogenesis 19990401

• Alterations in the growth factor signal transduction pathways and modulators of the cell cycle in endocervical cells from macaques exposed to TCDD.

  Toxicology and applied pharmacology 19980801

• Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.

  Environmental health perspectives 19980201

• 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced activation of a protein tyrosine kinase, pp60src, in murine hepatic cytosol using a cell-free system.

  Molecular pharmacology 19971001

• Identification of enzymes involved in the metabolism of atrazine, terbuthylazine, ametryne, and terbutryne in human liver microsomes.

  Chemical research in toxicology 19970901

• Examination of purported probes of human CYP2B6.

  Pharmacogenetics 19970601

• Carbaryl induces CYP1A1 gene expression in HepG2 and HaCaT cells but is not a ligand of the human hepatic Ah receptor.

  Toxicology and applied pharmacology 19970501

• A benzo[a]pyrene-induced cell cycle checkpoint resulting in p53-independent G1 arrest in 3T3 fibroblasts.

  The Journal of biological chemistry 19970131

• Identification of c-Src as the integral component of the cytosolic Ah receptor complex, transducing the signal of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through the protein phosphorylation pathway.

  Biochemical pharmacology 19961122

• Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes.

  Xenobiotica; the fate of foreign compounds in biological systems 19960701

• Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage.

  Proceedings of the National Academy of Sciences of the United States of America 19960319

• Interactions of flavonoids and other phytochemicals with adenosine receptors.

  Journal of medicinal chemistry 19960202

• 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) modulates function of human luteinizing granulosa cells via cAMP signaling and early reduction of glucose transporting activity.

  Reproductive toxicology (Elmsford, N.Y.) 19960101

• Protective action of dehydroascorbic acid on the Ah receptor-dependent and receptor-independent induction of lipid peroxidation in adipose tissue of male guinea pig caused by TCDD administration.

  Journal of biochemical toxicology 19960101

• In vitro inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced activity by alpha-naphthoflavone and 6-methyl-1,3,8-trichlorodibenzofuran using an aryl hydrocarbon (Ah)-responsive construct.

  Biochemical pharmacology 19950825

• Cytochrome P450 forms in the rodent lung involved in the metabolic activation of food-derived heterocyclic amines.

  Carcinogenesis 19930901

• Mechanism of action of alpha-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells.

  Toxicology and applied pharmacology 19930601

• Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.

  Archives of biochemistry and biophysics 19921101

• Role of phospholipids in reconstituted cytochrome P450 3A form and mechanism of their activation of catalytic activity.

  Biochemistry 19920707

• Metabolism of food-derived heterocyclic amines in human and rabbit tissues by P4503A proteins in the presence of flavonoids.

  Cancer research 19920401

• Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4'-methylene-bis(2-chloroaniline).

  Carcinogenesis 19920201

• Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes.

  Cancer research 19911001

• Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae.

  Biochemistry 19901225

• Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes.

  Cancer research 19900401

• Effect of benzopyrone derivatives on drug activity and metabolism.

  European journal of drug metabolism and pharmacokinetics 19860101

• The influence of simple aromatics on benzene clastogenicity.

  Mutation research 19840901

• Inducibility of arylhydrocarbon-hydroxylase activity in human hair follicles by topical application of liquor carbonis detergens (coal tar).

  The British journal of dermatology 19840901

• High incidence of hepatocellular carcinomas after synthetic estrogen administration in Syrian golden hamsters fed alpha-naphthoflavone: a new tumor model.

  Journal of the National Cancer Institute 19840801