607742-69-8 | Quinoline, 3-(phenylsulfonyl)-8-(1-piperazinyl)-

Packsize	Purity	Availability	Price	Discounted Price
1mg	97%	in stock	$35.00	$24.00
5mg	97%	in stock	$49.00	$34.00
10mg	97%	in stock	$63.00	$44.00
50mg	97%	in stock	$105.00	$73.00
100mg	97%	in stock	$176.00	$123.00
250mg	97%	in stock	$406.00	$284.00

Description

• Catalog Number: AG69062
• Chemical Name: Quinoline, 3-(phenylsulfonyl)-8-(1-piperazinyl)-
• CAS Number: 607742-69-8
• Molecular Formula: C19H19N3O2S
• Molecular Weight: 353.43806
• MDL Number: MFCD12828872
• SMILES: O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1

Computed Properties

• Complexity: 535
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• XLogP3: 2.5

Literature

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  CNS drugs 20170101

• Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.

  Journal of medicinal chemistry 20140911

• Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands.

  Journal of medicinal chemistry 20140710

• Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457.

  Neuropharmacology 20121001

• Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT₆ receptor antagonist showing activity in rat social recognition test.

  Bioorganic & medicinal chemistry letters 20120201

• Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.

  Journal of medicinal chemistry 20111208

• Central nervous system effects of the interaction between risperidone (single dose) and the 5-HT6 antagonist SB742457 (repeated doses) in healthy men.

  British journal of clinical pharmacology 20110601

• SB-742457 and donepezil in Alzheimer disease: a randomized, placebo-controlled study.

  International journal of geriatric psychiatry 20110501

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  Current Alzheimer research 20100801

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  Journal of medicinal chemistry 20100722

• Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms.

  Psychopharmacology 20100101

• 5-HT6 receptor antagonists as potential therapeutics for cognitive impairment.

  Current topics in medicinal chemistry 20100101

• Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands.

  Bioorganic & medicinal chemistry letters 20090615