608-07-1 | 5-Methoxytryptamine

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$13.00	$9.00
25g	98%	in stock	$52.00	$36.00
100g	98%	in stock	$155.00	$108.00
250g	98%	in stock	$305.00	$213.00
500g	98%	in stock	$515.00	$360.00
1kg	98%	in stock	$940.00	$658.00

Description

• Catalog Number: AB63099
• Chemical Name: 5-Methoxytryptamine
• CAS Number: 608-07-1
• Molecular Formula: C11H14N2O
• Molecular Weight: 190.24166000000005
• MDL Number: MFCD00005662
• SMILES: NCCc1c[nH]c2c1cc(OC)cc2
• NSC Number: 56422

Computed Properties

• Complexity: 186
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: 0.5

Literature

• Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.

  Scientific reports 20180101

• The recreational tryptamine 5-MeO-DALT (N,N-diallyl-5-methoxytryptamine): a brief review.

  Progress in neuro-psychopharmacology & biological psychiatry 20121203

• Binary fluorous alkylation of biogenic primary amines with perfluorinated aldehyde followed by fluorous liquid chromatography-tandem mass spectrometry analysis.

  Analytical chemistry 20121002

• Melatonin and synthetic melatonergic agonists: actions and metabolism in the central nervous system.

  Central nervous system agents in medicinal chemistry 20120901

• Assessment of the pharmacological properties of 5-methoxyindole derivatives at 5-HT4 receptors.

  The Journal of pharmacy and pharmacology 20120801

• The antioxidant behaviour of melatonin and structural analogues during lipid peroxidation depends not only on their functional groups but also on the assay system.

  Biochemical and biophysical research communications 20120713

• Total synthesis of Akuammiline alkaloid (-)-vincorine via intramolecular oxidative coupling.

  Journal of the American Chemical Society 20120606

• Prospective acetylcholinesterase inhibitory activity of indole and its analogs.

  Bioorganic & medicinal chemistry letters 20120415

• Inotropic effects of prokinetic agents with 5-HT(4) receptor agonist actions on human isolated myocardial trabeculae.

  Life sciences 20120409

• 5-HT receptors as novel targets for optimizing pigmentary responses in dorsal skin melanophores of frog, Hoplobatrachus tigerinus.

  British journal of pharmacology 20120301

• Developmental exposure to a serotonin agonist produces subsequent behavioral and neurochemical changes in the adult male prairie vole.

  Physiology & behavior 20120118

• Principles of psychoneuroendocrinoimmunotherapy of cancer.

  Immunotherapy 20120101

• Effects of power frequency electromagnetic fields on melatonin and sleep in the rat.

  Emerging health threats journal 20120101

• A reinterpretation of the pathogenesis and cure of cancer according to the psychoneuroimmunological discoveries.

  Methods in molecular biology (Clifton, N.J.) 20120101

• Inhibition of itch-related responses at spinal level in rats.

  Acta physiologica Hungarica 20111201

• A quantitative method for simultaneous determination of 5-methoxy-N,N-diisopropyltryptamine and its metabolites in urine using liquid chromatography-electrospray ionization-tandem mass spectrometry.

  Journal of forensic sciences 20110701

• Measurement of melatonin in body fluids: standards, protocols and procedures.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20110601

• 5-methoxy-N,N-di(iso)propyltryptamine hydrochloride (Foxy)-induced cognitive deficits in rat after exposure in adolescence.

  Physiology & behavior 20110503

• Preliminary analgesic properties of deltorphin-5-methoxytryptamine chimeric opioid peptides.

  Peptides 20110501

• Melatonin as an antioxidant and its semi-lunar rhythm in green macroalga Ulva sp.

  Journal of experimental botany 20110301

• Drug-induced psychosis: how to avoid star gazing in schizophrenia research by looking at more obvious sources of light.

  Frontiers in behavioral neuroscience 20110101

• The impact of serotonergic stimulation on reelin and glutamate decarboxylase gene expression in adult female rats.

  Bratislavske lekarske listy 20110101

• [Radioprotective properties of indralin combined with cystamine and mexamine].

  Radiatsionnaia biologiia, radioecologiia 20110101

• Evaluation of nootropic and neuroprotective effects of low dose aspirin in rats.

  Journal of pharmacology & pharmacotherapeutics 20110101

• Current state of type 1 diabetes immunotherapy: incremental advances, huge leaps, or more of the same?

  Clinical & developmental immunology 20110101

• Subjective food hypersensitivity: assessment of enterochromaffin cell markers in blood and gut lavage fluid.

  International journal of general medicine 20110101

• Serotonin-induced contraction in isolated intestine from a teleost fish (Carassius auratus): characterization and interactions with melatonin.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20101201

• 5-benzyloxytryptamine as an antagonist of TRPM8.

  Bioorganic & medicinal chemistry letters 20101201

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Melatonin metabolism in the central nervous system.

  Current neuropharmacology 20100901

• Development and validation of a high throughput direct radioimmunoassay for the quantitative determination of serum and plasma melatonin (N-acetyl-5-methoxytryptamine) in mice.

  Journal of immunological methods 20100630

• Tandem intramolecular photocycloaddition-retro-Mannich fragmentation as a route to spiro[pyrrolidine-3,3'-oxindoles]. Total synthesis of (+/-)-coerulescine, (+/-)-horsfiline, (+/-)-elacomine, and (+/-)-6-deoxyelacomine.

  The Journal of organic chemistry 20100604

• Brain chemistry: how does P450 catalyze the O-demethylation reaction of 5-methoxytryptamine to yield serotonin?

  The journal of physical chemistry. B 20100527

• Biogenic amines modulate pulse rate in the dorsal blood vessel of Lumbriculus variegatus.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20100501

• MT1 melatonin receptors mediate somatic, behavioral, and reproductive neuroendocrine responses to photoperiod and melatonin in Siberian hamsters (Phodopus sungorus).

  Endocrinology 20100201

• Glucose and corticosterone changes in developing and adult rats following exposure to (+/-)-3,4-methylendioxymethamphetamine or 5-methoxydiisopropyltryptamine.

  Neurotoxicology and teratology 20100101

• Cytosine methylation dysregulation in neonates following intrauterine growth restriction.

  PloS one 20100101

• Melatonin and structurally-related compounds protect synaptosomal membranes from free radical damage.

  International journal of molecular sciences 20100101

• Synthesis and preliminary screening of novel tryptamines as 5-HT4 receptor ligands.

  Current medicinal chemistry 20100101

• Circulating Antibodies to IDO/THO Pathway Metabolites in Alzheimer's Disease.

  International journal of Alzheimer's disease 20100101

• Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands.

  The Biochemical journal 20091023

• N-[(Dihydroxyphenyl)acyl]serotonins as potent inhibitors of tyrosinase from mouse and human melanoma cells.

  Bioorganic & medicinal chemistry letters 20090801

• Synthesis and preliminary screening of novel indole-3-methanamines as 5-HT4 receptor ligands.

  European journal of medicinal chemistry 20090701

• The serotonergic system: its role in pathogenesis and early developmental treatment of autism.

  Current neuropharmacology 20090601

• The conformational landscape of 5-methoxytryptamine studied by rotationally resolved fluorescence spectroscopy and resonant ionization spectroscopy.

  Physical chemistry chemical physics : PCCP 20090414

• Effects of naphthalene, beta-naphthoflavone and benzo(a)pyrene on the diurnal and nocturnal indoleamine metabolism and melatonin content in the pineal organ of rainbow trout, Oncorhynchus mykiss.

  Aquatic toxicology (Amsterdam, Netherlands) 20090402

• New approaches in the management of insomnia: weighing the advantages of prolonged-release melatonin and synthetic melatoninergic agonists.

  Neuropsychiatric disease and treatment 20090101

• The use of tripeptides for lead discovery of 5-HT4 receptor ligands.

  Protein and peptide letters 20090101

• Melatonin, hormone of darkness and more: occurrence, control mechanisms, actions and bioactive metabolites.

  Cellular and molecular life sciences : CMLS 20080701

• Contribution of active and inactive states of the human 5-HT4d receptor to the functional activities of 5-HT4-receptor agonists.

  Journal of pharmacological sciences 20080701

• Intraocular microinjections repair experimental Parkinson's disease.

  Brain research 20080627

• Indolealkylamines: biotransformations and potential drug-drug interactions.

  The AAPS journal 20080601

• Functional human 5-HT6 receptor assay for high throughput screening of chemical ligands and binding proteins.

  Combinatorial chemistry & high throughput screening 20080501

• Direct determination of serotonin in gut lavage fluid by liquid chromatographic ion trap tandem mass spectrometry.

  Talanta 20080415

• The roles of amino acid residues at positions 216 and 219 in the structural stability and metabolic functions of rat cytochrome P450 2D1 and 2D2.

  Chemico-biological interactions 20080310

• Solubilization of 5-methoxy tryptamine molecular probes in CTAB and SDS micelles: a cmc and binding constant study.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080301

• 5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function.

  European journal of pharmacology 20080212

• Oxidation of 5-methoxy-N,N-diisopropyltryptamine in rat liver microsomes and recombinant cytochrome P450 enzymes.

  Biochemical pharmacology 20080201

• Problems in three Japanese drug users with Human Immunodeficiency Virus infection.

  The journal of medical investigation : JMI 20080201

• Further studies in the developmental hyperserotonemia model (DHS) of autism: social, behavioral and peptide changes.

  Brain research 20080116

• Perinatal exposure to 5-methoxytryptamine, behavioural-stress reactivity and functional response of 5-HT1A receptors in the adolescent rat.

  Behavioural brain research 20080110

• Neuropsychotoxicity of abused drugs: molecular and neural mechanisms of neuropsychotoxicity induced by methamphetamine, 3,4-methylenedioxymethamphetamine (ecstasy), and 5-methoxy-N,N-diisopropyltryptamine (foxy).

  Journal of pharmacological sciences 20080101

• Evaluation of the effects of a new drug candidate (GEMSP) in a chronic EAE model.

  International journal of biological sciences 20080101

• [Protective action of radioprotectors and shielding against high-energy protons in experiments with rats].

  Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine 20080101

• Antioxidant systems and oxidative stress in the testes.

  Oxidative medicine and cellular longevity 20080101

• Effect of CTAB and SDS micelles on the excited state equilibria of some indole probes.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071101

• Effects of pre- and postnatal exposure to 5-methoxytryptamine and early handling on an object-place association learning task in adolescent rat offspring.

  Neuroscience research 20070901

• Pharmacology of serotonin-induced salivary secretion in Periplaneta americana.

  Journal of insect physiology 20070801

• The effect of melatonin and structural analogues on the lipid peroxidation of triglycerides enriched in omega-3 polyunsaturated fatty acids.

  Life sciences 20070704

• Alterations in body temperature, corticosterone, and behavior following the administration of 5-methoxy-diisopropyltryptamine ('foxy') to adult rats: a new drug of abuse.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070601

• CYP2D6 genotype in relation to perphenazine concentration and pituitary pharmacodynamic tissue sensitivity in Asians: CYP2D6-serotonin-dopamine crosstalk revisited.

  Pharmacogenetics and genomics 20070501

• 5-Methoxy-N,N-diisopropyltryptamine (Foxy), a selective and high affinity inhibitor of serotonin transporter.

  Toxicology letters 20070405

• Acute confusional state after designer tryptamine abuse.

  Psychiatry and clinical neurosciences 20070401

• Dimethyl sulfoxide: an antagonist in scintillation proximity assay [(35)S]-GTPgammaS binding to rat 5-HT(6) receptor cloned in HEK-293 cells?

  Journal of neuroscience methods 20070315

• Nitration of specific tyrosine residues of cytochrome C is associated with caspase-cascade inactivation.

  Biological & pharmaceutical bulletin 20070101

• Indorenate improves motor function in rats with chronic spinal cord injury.

  Basic & clinical pharmacology & toxicology 20070101

• Biochemotherapy with immunomodulating pineal hormones other than melatonin: 5-methoxytryptamine as a new oncostatic pineal agent.

  Pathologie-biologie 20070101

• [Comparative protective action of radiorotectors and shielding in gamma-irradiated mice].

  Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine 20070101

• [5-hydroxytryptamine and 5-methoxytryptamine increase tolerance to global cerebral ischemia].

  Eksperimental'naia i klinicheskaia farmakologiia 20070101

• Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors.

  European journal of pharmacology 20061215

• Could endogenous substrates of drug-metabolizing enzymes influence constitutive physiology and drug target responsiveness?

  Pharmacogenomics 20061201

• Functional activity of 5-HT4 receptors in children with congenital heart disease.

  Bulletin of experimental biology and medicine 20061201

• A fatal poisoning with 5-methoxy-N,N-diisopropyltryptamine, Foxy.

  Forensic science international 20061110

• Tryptamine induces cell death with ultrastructural features of autophagy in neurons and glia: Possible relevance for neurodegenerative disorders.

  The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 20060901

• Human trabecular meshwork cells express functional serotonin-2A (5HT2A) receptors: role in IOP reduction.

  Investigative ophthalmology & visual science 20060901

• Indorenate modifies a1-adrenergic and benzodiazepine receptor binding in the rat brain: an autoradiography study.

  The Journal of pharmacy and pharmacology 20060901

• Functional roles of 5-hydroxytryptamine 3/4 receptors in neurons of rat dorsal motor nucleus of the vagus.

  Neuroscience 20060825

• 1H- and 13C-NMR, FTIR, UV-VIS, ESI-MS, and PM5 studies as well as emission properties of a new Schiff base of gossypol with 5-methoxytryptamine and a new hydrazone of gossypol with dansylhydrazine.

  Biopolymers 20060805

• An examination of the effects of 5-Methoxy-n, n-di(ISO)propyltryptamine hydrochloride (Foxy) on cognitive development in rats.

  Psychological reports 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Preparation and identification of anti-melatonin monoclonal antibodies.

  Journal of pineal research 20060501

• Oxidative metabolism of 5-methoxy-N,N-diisopropyltryptamine (Foxy) by human liver microsomes and recombinant cytochrome P450 enzymes.

  Biochemical pharmacology 20060428

• Pharmacological characterization of 5-hydroxytryptamine-induced contraction in the chicken gastrointestinal tract.

  Autonomic & autacoid pharmacology 20060401

• Rhabdomyolysis after ingestion of 'foxy,' a hallucinogenic tryptamine derivative.

  Mayo Clinic proceedings 20060401

• A 3-synapse positive feedback loop regulates the excitability of an interneuron critical for sensitization in the leech.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060329

• Solvent effects in the preparation of molecularly imprinted polymers for melatonin using N-propionyl-5-methoxytryptamine as the pseudo template.

  Analytical and bioanalytical chemistry 20060301

• On-line preconcentration techniques in determination of melatonin and its precursors/metabolites using micellar electrokinetic chromatography.

  Journal of chromatography. A 20060203

• Metabolism of the psychotomimetic tryptamine derivative 5-methoxy-N,N-diisopropyltryptamine in humans: identification and quantification of its urinary metabolites.

  Drug metabolism and disposition: the biological fate of chemicals 20060201

• Simultaneous liquid chromatographic measurement of melatonin and related indoles through post-column electrochemical demethylation and fluorescence derivatization.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20060201

• Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats.

  Pharmacology, biochemistry, and behavior 20060101

• Functional and molecular identification of 5-hydroxytryptamine receptors in rabbit pulmonary artery: involvement in complex regulation of noradrenaline release.

  Pharmacological reports : PR 20060101

• Substance use and sexual behaviours of Japanese men who have sex with men: a nationwide internet survey conducted in Japan.

  BMC public health 20060101

• Foxy methoxy: a new drug of abuse.

  Journal of medical toxicology : official journal of the American College of Medical Toxicology 20051201

• [Melatoninergic receptor agonists and antagonists: pharmacological aspects and therapeutic perspective].

  Annales pharmaceutiques francaises 20051101

• Determination of melatonin and its precursors and metabolites using capillary electrophoresis with UV and fluorometric detection.

  Journal of separation science 20051101

• Indoleamines and 5-methoxyindoles in trout pineal organ in vivo: daily changes and influence of photoperiod.

  General and comparative endocrinology 20051001

• 5-HT1A receptor agonists modify epileptic seizures in three experimental models in rats.

  Neuropharmacology 20050901

• The role of ML-23 and other melatonin analogues in the treatment and management of Parkinson's disease.

  Drug news & perspectives 20050901

• Sensitive determination of alpha-methyltryptamine (AMT) and 5-methoxy-N,N-diisopropyltryptamine (5MeO-DIPT) in whole blood and urine using gas chromatography-mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050825

• Impact of the CYP2D6 ultra-rapid metabolizer genotype on doxepin pharmacokinetics and serotonin in platelets.

  Pharmacogenetics and genomics 20050801

• Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells.

  Neuropharmacology 20050701

• Clozapine attenuates the locomotor sensitisation and the prepulse inhibition deficit induced by a repeated oral administration of Catha edulis extract and cathinone in rats.

  Behavioural brain research 20050528

• Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.

  Journal of medicinal chemistry 20050324

• A foxy intoxication.

  Forensic science international 20050210

• Voltage-dependent inhibition of recombinant NMDA receptor-mediated currents by 5-hydroxytryptamine.

  British journal of pharmacology 20050201

• Behavioral and cellular consequences of increasing serotonergic activity during brain development: a role in autism?

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20050201

• Effect of the postsynaptic 5-HT1A receptor antagonist MM-77 on stressed mice treated with 5-HT1A receptor agents.

  European journal of pharmacology 20050131

• Recovery from experimental Parkinson's disease in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride treated marmoset with the melatonin analogue ML-23.

  Pharmacology, biochemistry, and behavior 20050101

• Evidence for 5-HT2B and 5-HT7 receptor-mediated relaxation in pulmonary arteries of weaned pigs.

  Naunyn-Schmiedeberg's archives of pharmacology 20050101

• Statistical distribution of blood serotonin as a predictor of early autistic brain abnormalities.

  Theoretical biology & medical modelling 20050101

• Melatonin, a potent agent in antioxidative defense: actions as a natural food constituent, gastrointestinal factor, drug and prodrug.

  Nutrition & metabolism 20050101

• Rapid, accurate and precise quantitative drug analysis: comparing liquid chromatography tandem mass spectrometry and chip-based nanoelectrospray ionisation mass spectrometry.

  European journal of mass spectrometry (Chichester, England) 20050101

• The actions of a charged melatonin receptor ligand, TMEPI, and an irreversible MT2 receptor agonist, BMNEP, on mouse hippocampal evoked potentials in vitro.

  Life sciences 20041112

• Analytical chemistry of synthetic routes to psychoactive tryptamines. Part I. Characterisation of the Speeter and Anthony synthetic route to 5-methoxy-N,N-diisopropyltryptamine using ESI-MS-MS and ESI-TOF-MS.

  The Analyst 20041101

• Recovery of experimental Parkinson's disease with the melatonin analogues ML-23 and S-20928 in a chronic, bilateral 6-OHDA model: a new mechanism involving antagonism of the melatonin receptor.

  Pharmacology, biochemistry, and behavior 20041101

• Functional expression of the serotonin 5-HT7 receptor in human glioblastoma cell lines.

  British journal of pharmacology 20041001

• New drugs of abuse update: Foxy Methoxy.

  Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association 20041001

• A general screening and confirmation approach to the analysis of designer tryptamines and phenethylamines in blood and urine using GC-EI-MS and HPLC-electrospray-MS.

  Journal of analytical toxicology 20040901

• Opposing electrophysiological actions of 5-HT on noncholinergic and cholinergic neurons in the rat ventral pallidum in vitro.

  Journal of neurophysiology 20040701

• [Latest cases of acute poisoning in clinical practice--5MeO-DIPT and GHB precursor].

  Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology 20040701

• Binding of tryptamine analogs at h5-HT1E receptors: a structure-affinity investigation.

  Bioorganic & medicinal chemistry 20040515

• Inhibition of p38 mitogen-activated protein kinase enhances adrenergic-stimulated arylalkylamine N-acetyltransferase activity in rat pinealocytes.

  Endocrinology 20040301

• Endogenous and dietary indoles: a class of antioxidants and radical scavengers in the ABTS assay.

  Free radical research 20040301

• Early serotonergic projections to Cajal-Retzius cells: relevance for cortical development.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040218

• Involvement of melatonin metabolites in the long-term inhibitory effect of the hormone on rat spinal nociceptive transmission.

  Pharmacology, biochemistry, and behavior 20040201

• Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor.

  European journal of pharmacology 20040126

• Autoradiographic distribution of 5-HT7 receptors in the human brain using [3H]mesulergine: comparison to other mammalian species.

  British journal of pharmacology 20040101

• Synthesis of internal labeled standards of melatonin and its metabolite N1-acetyl-N2-formyl-5-methoxykynuramine for their quantification using an on-line liquid chromatography-electrospray tandem mass spectrometry system.

  Journal of pineal research 20040101

• Selective scavenging property of the indole moiety for the nitrating species of peroxynitrite.

  Chemical & pharmaceutical bulletin 20040101

• The implementation of acute versus chronic animal models for treatment discovery in Parkinson's disease.

  Reviews in the neurosciences 20040101

• Peroxynitrite scavenging activity of indole derivatives: interaction of indoles with peroxynitrite.

  Journal of medicinal food 20040101

• Characterization of the 5-HT(7) receptor. Determination of the pharmacophore for 5-HT(7) receptor agonism and CoMFA-based modeling of the agonist binding site.

  Journal of medicinal chemistry 20031204

• Expression of human organic anion transporters in the choroid plexus and their interactions with neurotransmitter metabolites.

  Journal of pharmacological sciences 20031201

• Pharmacological characterization of a serotonin receptor (5-HT7) stimulating cAMP production in human corneal epithelial cells.

  Investigative ophthalmology & visual science 20031101

• Interaction of singlet molecular oxygen with melatonin and related indoles.

  Photochemistry and photobiology 20031101

• Depression of mGluR-mediated IPSCs by 5-HT in dopamine neurons of the rat substantia nigra pars compacta.

  The European journal of neuroscience 20031101

• Circadian rhythms, oxidative stress, and antioxidative defense mechanisms.

  Chronobiology international 20031101

• Relative reactivities of histamine and indoleamines with acetaldehyde.

  Biological & pharmaceutical bulletin 20030801

• Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein.

  European journal of pharmacology 20030704

• Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).

  Journal of medicinal chemistry 20030703

• Functional activity of serotoninergic and melatoninergic systems expressed in the skin.

  Journal of cellular physiology 20030701

• [Levels of psilocybin and psilocin in various types of mushrooms].

  Soudni lekarstvi 20030701

• In search of endogenous CYP2D6 substrates.

  Pharmacogenetics 20030601

• Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase.

  Pharmacogenetics 20030601

• Fourier transform infrared spectra and molecular structure of 5-methoxytryptamine, N-acetyl-5-methoxytryptamine and N-phenylsulfonamide-5-methoxytryptamine.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030401

• Melatonin preserves arachidonic and docosapentaenoic acids during ascorbate-Fe2+ peroxidation of rat testis microsomes and mitochondria.

  The international journal of biochemistry & cell biology 20030301

• Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.

  Pharmacogenetics 20030301

• 5-HT7 receptor-mediated relaxation of the oviduct in nonpregnant proestrus pigs.

  European journal of pharmacology 20030214

• Photoperiod affects amplitude but not duration of in vitro melatonin production in the ruin lizard (Podarcis sicula).

  Journal of biological rhythms 20030201

• Further evidence that the discriminative stimulus properties of indorenate are mediated by 5-HT 1A/1B/2C receptors.

  Pharmacology, biochemistry, and behavior 20030101

• Reduction of cisplatin-induced anemia by the pineal indole 5-methoxytryptamine in metastatic lung cancer patients.

  Neuro endocrinology letters 20030101

• Foxy, a designer tryptamine hallucinogen.

  Journal of analytical toxicology 20030101

• Total pineal endocrine substitution therapy (TPEST) as a new neuroendocrine palliative treatment of untreatable metastatic solid tumor patients: a phase II study.

  Neuro endocrinology letters 20030101

• Photochemical properties of kynurenine pathway metabolites and indoleamines.

  Advances in experimental medicine and biology 20030101

• Indorenate produces antidepressant-like actions in the rat forced swimming test via 5-HT1A receptors.

  Psychopharmacology 20021201

• Role of melatonin in the induction and maintenance of sleep.

  Dialogues in clinical neuroscience 20021201

• Melatonin's unique radical scavenging properties - roles of its functional substituents as revealed by a comparison with its structural analogs.

  Journal of pineal research 20020801

• Characterization and regulation of a CHO cell line stably expressing human serotonin N-acetyltransferase (EC 2.3.1.87).

  Cellular and molecular life sciences : CMLS 20020801

• The effects of treatment with melatonin on the ultrastructure of mouse Leydig cells: a quantitative study.

  Brazilian journal of biology = Revista brasleira de biologia 20020801

• Influence of forced swimming-induced stress on the anxiolytic-like effect of 5HT(1A) agents in mice.

  Psychopharmacology 20020701

• Full substitution of the discriminative cue of a 5-HT(1A/1B/2C) agonist with the combined administration of a 5-HT(1B/2C) and a 5-HT(1A) agonist.

  Behavioural pharmacology 20020701

• Demonstration of antifungal and anti-human immunodeficiency virus reverse transcriptase activities of 6-methoxy-2-benzoxazolinone and antibacterial activity of the pineal indole 5-methoxyindole-3-acetic acid.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020601

• Modulation of 5-HT4 receptor function in the rat isolated ileum by fluoxetine: the involvement of endogenous 5-hydroxytryptamine.

  British journal of pharmacology 20020501

• Activity-dependent bidirectional regulation of GABA(A) receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neurons.

  The Journal of physiology 20020501

• Desensitization of pigment granule aggregation in Xenopus leavis melanophores: melatonin degradation rather than receptor down-regulation is responsible.

  Journal of neurochemistry 20020501

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Generalized loss of inhibitory innervation reverses serotonergic inhibition into excitation in a rabbit model of TNBS-colitis.

  British journal of pharmacology 20020401

• The neuroprotective activities of melatonin against the Alzheimer beta-protein are not mediated by melatonin membrane receptors.

  Journal of pineal research 20020401

• DARPP-32 mediates serotonergic neurotransmission in the forebrain.

  Proceedings of the National Academy of Sciences of the United States of America 20020305

• Behavioral and magnetic resonance spectroscopic studies in the rat hyperserotonemic model of autism.

  Physiology & behavior 20020301

• Modulation by serotonin 5-HT(4) receptors of long-term potentiation and depotentiation in the dentate gyrus of freely moving rats.

  Cerebral cortex (New York, N.Y. : 1991) 20020201

• Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells.

  FEBS letters 20020130

• Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins.

  Molecular pharmacology 20020101

• Clinical safety and effectiveness of indorenate in essential hypertension.

  Proceedings of the Western Pharmacology Society 20020101

• [Study of the antiradical and radioprotective properties of S-containing compounds using the complex of in vitro test-systems].

  Radiatsionnaia biologiia, radioecologiia 20020101

• Functional modification of cytochrome c by peroxynitrite in an electron transfer reaction.

  Chemical & pharmaceutical bulletin 20011201

• [Morphofunctional changes in the pineal gland during adaptation to hypothermia].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20011201

• Examination of pineal indoles and 6-methoxy-2-benzoxazolinone for antioxidant and antimicrobial effects.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20011101

• Guest-to-host proton transfer in melatonin-beta-cyclodextrin inclusion complex by ionspray, fast atom bombardment and tandem mass spectrometry.

  Journal of mass spectrometry : JMS 20011101

• Effect of carrier excipient and processing on stability of indorenate hydrochloride/excipient mixtures.

  Pharmaceutical development and technology 20011101

• Synthesis of valproic acid amides of a melatonin derivative, a piracetam and amantadine for biological tests.

  Neurochemical research 20011001

• [Presynaptic 5-hydroxytryptamine receptors enhance cholinergic neurosecretion in the human iris-ciliary body].

  [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20010901

• Putative regulatory molecules in plants: evaluating melatonin.

  Journal of pineal research 20010801

• The effects of acute melatonin and ethanol treatment on antioxidant enzyme activities in rat testes.

  Pharmacological research 20010801

• [(3)H]-serotonin release from bovine iris-ciliary body: pharmacology of prejunctional serotonin (5-HT(7)) autoreceptors.

  Experimental eye research 20010701

• The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution.

  Naunyn-Schmiedeberg's archives of pharmacology 20010601

• A 5-HT(7) receptor-mediated depolarization in the anterodorsal thalamus. I. Pharmacological characterization.

  The Journal of pharmacology and experimental therapeutics 20010401

• Thrombopoietic properties of 5-methoxytryptamine plus melatonin versus melatonin alone in the treatment of cancer-related thrombocytopenia.

  Journal of pineal research 20010301

• Discriminative stimulus properties of indorenate, a 5-HT1A, 5-HT1B and 5-HT2C agonist: a study in rats.

  Journal of psychopharmacology (Oxford, England) 20010301

• Discriminative stimulus properties of indorenate in a conditioned taste aversion paradigm.

  Pharmacology, biochemistry, and behavior 20010301

• Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex.

  Brain research 20010202

• 5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle.

  Naunyn-Schmiedeberg's archives of pharmacology 20010201

• Unravelling the pharmacological profile of the canine external carotid vasodilator '5-HT1-like' receptors: coexistence of sympatho-inhibitory 5-HT1B and postjunctional 5-HT7 receptors.

  Naunyn-Schmiedeberg's archives of pharmacology 20010101

• High-performance liquid chromatography assay for indorenate in pharmaceutical powders.

  Drug development and industrial pharmacy 20010101

• Pineal indoles stimulate the gene expression of immunomodulating cytokines.

  Journal of neural transmission (Vienna, Austria : 1996) 20010101

• Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells.

  British journal of pharmacology 20001001

• 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.

  Journal of medicinal chemistry 20000309

• Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors.

  Synapse (New York, N.Y.) 20000201

• Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.

  Journal of neurochemistry 20000201

• Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines.

  British journal of pharmacology 20000201

• Identification of residues in transmembrane regions III and VI that contribute to the ligand binding site of the serotonin 5-HT6 receptor.

  Journal of neurochemistry 19981101

• Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus.

  Journal of neurochemistry 19980601

• Cloning and expression of a human serotonin 5-HT4 receptor cDNA.

  Journal of neurochemistry 19971101

• Activating mutations of the serotonin 5-HT2C receptor.

  Journal of neurochemistry 19970901

• Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b).

  British journal of pharmacology 19970901

• [3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guinea-pig striatal and rat cloned (5-HT4S and 5-HT4L) receptors.

  Neuropharmacology 19970101

• Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells.

  Neuropharmacology 19970101

• Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan.

  Molecular pharmacology 19961201

• Cloning, expression and pharmacology of the mouse 5-HT(4L) receptor.

  FEBS letters 19961125

• Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors.

  Journal of neurochemistry 19961101

• [3H]5-hydroxytryptamine labels the agonist high affinity state of the cloned rat 5-HT4 receptor.

  European journal of pharmacology 19960523

• Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor.

  Journal of neurochemistry 19960101

• The 5-HT4 receptor: molecular cloning and pharmacological characterization of two splice variants.

  The EMBO journal 19950615

• Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines.

  Molecular pharmacology 19940201

• Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.

  The Journal of biological chemistry 19931105

• Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.

  Proceedings of the National Academy of Sciences of the United States of America 19930915

• Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.

  The Journal of biological chemistry 19930825

• Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.

  Molecular pharmacology 19930801

• The role of receptor binding in drug discovery.

  Journal of natural products 19930401

• Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.

  Molecular pharmacology 19930301

• Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.

  Molecular pharmacology 19930301

• Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.

  Proceedings of the National Academy of Sciences of the United States of America 19930115

• Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.

  Proceedings of the National Academy of Sciences of the United States of America 19920415

• Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.

  Molecular pharmacology 19910801