6112-76-1 | 6-Mercaptopurine monohydrate

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	in stock	$15.00	$10.00
5g	97%	in stock	$16.00	$11.00
10g	97%	in stock	$29.00	$20.00
25g	97%	in stock	$35.00	$24.00
100g	97%	in stock	$115.00	$80.00
500g	97%	in stock	$548.00	$383.00

Description

• Catalog Number: AB69904
• Chemical Name: 6-Mercaptopurine monohydrate
• CAS Number: 6112-76-1
• Molecular Formula: C5H6N4OS
• Molecular Weight: 170.1923
• MDL Number: MFCD03854445
• SMILES: Sc1ncnc2c1[nH]cn2.O

Computed Properties

• Complexity: 190
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 3

Literature

• Risk factors for thiopurine-induced myelosuppression and infections in inflammatory bowel disease patients with a normal TPMT genotype.

  Alimentary pharmacology & therapeutics 20171101

• HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants.

  Nature genetics 20141001

• Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia.

  Pharmacogenetics and genomics 20140801

• Microarray analysis of 6-mercaptopurine-induced-toxicity-related genes and microRNAs in the rat placenta.

  The Journal of toxicological sciences 20130201

• Fabrication of biodegradable micelles with reduction-triggered release of 6-mercaptopurine profile based on disulfide-linked graft copolymer conjugate.

  Colloids and surfaces. B, Biointerfaces 20121201

• S-allyl derivatives of 6-mercaptopurine are highly potent drugs against human B-CLL through synergism between 6-mercaptopurine and allicin.

  Leukemia research 20121201

• The investigation of the binding of 6-mercaptopurine to site I on human serum albumin.

  The protein journal 20121201

• 6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.

  European journal of pharmacology 20121115

• Asparaginase-associated myelosuppression and effects on dosing of other chemotherapeutic agents in childhood acute lymphoblastic leukemia.

  Pediatric blood & cancer 20121101

• Pregnancy outcome after paternal exposure to azathioprine/6-mercaptopurine.

  Reproductive toxicology (Elmsford, N.Y.) 20121101

• PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity.

  Human molecular genetics 20121101

• Preparation, characterization and in vitro release study of a glutathione-dependent polymeric prodrug Cis-3-(9H-purin-6-ylthio)-acrylic acid-graft-carboxymethyl chitosan.

  International journal of pharmaceutics 20121015

• A step toward more accurate dosing for mercaptopurine in childhood acute lymphoblastic leukemia.

  Journal of clinical pharmacology 20121001

• Long-term MRI-guided combined anti-TNF-α and thiopurine therapy for Crohn's perianal fistulas.

  Inflammatory bowel diseases 20121001

• Increased small intestinal permeability in ulcerative colitis: rather genetic than environmental and a risk factor for extensive disease?

  Inflammatory bowel diseases 20121001

• Optimising outcome on thiopurines in inflammatory bowel disease by co-prescription of allopurinol.

  Journal of Crohn's & colitis 20121001

• Current relevance of pharmacogenetics in immunomodulation treatment for Crohn's disease.

  Journal of gastroenterology and hepatology 20121001

• Treatment of young patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia using increased dose of imatinib and deintensified chemotherapy before allogeneic stem cell transplantation.

  British journal of haematology 20121001

• Establishment of thiopurine S-methyltransferase gene knockdown in jurkat T-lymphocytes: an in vitro model of TPMT polymorphism.

  Therapeutic drug monitoring 20121001

• Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis.

  The Cochrane database of systematic reviews 20120912

• Prevention and synergistic control of Ph(+) ALL by a DNA vaccine and 6-mercaptopurine.

  Vaccine 20120907

• Comparative cost-effectiveness of strategies to prevent postoperative clinical recurrence of Crohn's disease.

  Inflammatory bowel diseases 20120901

• Incidence of and impact of medications on colectomy in newly diagnosed ulcerative colitis in the era of biologics.

  Inflammatory bowel diseases 20120901

• Nine years interval between first and second bone marrow transplantations and subsequent long-term survival--a case of acute myeloid leukemia with MLL-AF6 fusion gene.

  Annals of hematology 20120901

• Pharmacogenetic determinants of mercaptopurine disposition in children with acute lymphoblastic leukemia.

  European journal of clinical pharmacology 20120901

• Split-dose administration of thiopurine drugs: a novel and effective strategy for managing preferential 6-MMP metabolism.

  Alimentary pharmacology & therapeutics 20120901

• Immunosuppression in patients with Crohn's disease and neoplasia: an ongoing clinical dilemma.

  Diseases of the colon and rectum 20120901

• Nutritional therapy versus 6-mercaptopurine as maintenance therapy in patients with Crohn's disease.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20120801

• Risk of melanoma and nonmelanoma skin cancer among patients with inflammatory bowel disease.

  Gastroenterology 20120801

• The potential influence of 5-aminosalicylic acid on the induction of myelotoxicity during thiopurine therapy in inflammatory bowel disease patients.

  European journal of gastroenterology & hepatology 20120801

• [Thiopurine S-methyltransferase gene sequence analysis of ALL children severely intolerant to 6-mercaptopurine].

  Zhongguo shi yan xue ye xue za zhi 20120801

• Label-free, non-derivatization CRET detection platform for 6-mercaptopurine based on the distance-dependent optical properties of gold nanoparticles.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20120702

• Prediction of outcome by early bone marrow response in childhood acute lymphoblastic leukemia treated in the ALL-BFM 95 trial: differential effects in precursor B-cell and T-cell leukemia.

  Haematologica 20120701

• Genotyping should be considered the primary choice for pre-treatment evaluation of thiopurine methyltransferase function.

  Journal of Crohn's & colitis 20120701

• Prevention of postoperative recurrence of Crohn's disease.

  Journal of Crohn's & colitis 20120701

• Therapeutic drug monitoring of thiopurine metabolites in adult thiopurine tolerant IBD patients on maintenance therapy.

  Journal of Crohn's & colitis 20120701

• Intracellular disposition of methotrexate in acute lymphoblastic leukemia in children.

  Current drug metabolism 20120701

• Identifying youth nonadherence in clinical settings: data-based recommendations for children and adolescents with inflammatory bowel disease.

  Inflammatory bowel diseases 20120701

• Letter: TPMT - not all that glitters is gold.

  Alimentary pharmacology & therapeutics 20120701

• Genetic variants of thiopurine and folate metabolic pathways determine 6-MP-mediated hematological toxicity in childhood ALL.

  Pharmacogenomics 20120701

• Nonadherence to oral mercaptopurine and risk of relapse in Hispanic and non-Hispanic white children with acute lymphoblastic leukemia: a report from the children's oncology group.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120610

• Cryptosporidium gastroenteritis in Egyptian children with acute lymphoblastic leukemia: magnitude of the problem.

  Infection 20120601

• Thiopurine treatment in inflammatory bowel disease: response predictors, safety, and withdrawal in follow-up.

  Journal of Crohn's & colitis 20120601

• Optimizing immunomodulators and anti-TNF agents in the therapy of Crohn disease.

  Gastroenterology clinics of North America 20120601

• Infliximab exerts no direct hepatotoxic effect on HepG2 cells in vitro.

  Digestive diseases and sciences 20120601

• Langerhans cell histiocytosis presenting as a multi-system disorder in an infant.

  International journal of dermatology 20120601

• Intermittent granulocyte and monocyte apheresis versus mercaptopurine for maintaining remission of ulcerative colitis: a pilot study.

  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20120601

• A histopathologic pattern of centrilobular hepatocyte injury suggests 6-mercaptopurine-induced hepatotoxicity in patients with inflammatory bowel disease.

  Archives of pathology & laboratory medicine 20120601

• Ulcerative colitis.

  BMJ (Clinical research ed.) 20120510

• Comparison of clinical characteristics and management of inflammatory bowel disease in Hong Kong versus Melbourne.

  Journal of gastroenterology and hepatology 20120501

• Influence of age, sex, and haplotypes of thiopurine methyltransferase (TPMT) gene on 6- mercaptopurine toxicity in children with acute lymphoblastic leukemia.

  European journal of clinical pharmacology 20120501

• Factors associated with nonadherence to thiopurines in adolescent and adult patients with inflammatory bowel disease.

  Journal of pediatric gastroenterology and nutrition 20120501

• The activity of the inosine triphosphate pyrophosphatase affects toxicity of 6-mercaptopurine during maintenance therapy for acute lymphoblastic leukemia in Japanese children.

  Leukemia research 20120501

• Confocal Raman microspectroscopic study of folate receptor-targeted delivery of 6-mercaptopurine-embedded gold nanoparticles in a single cell.

  Journal of biomedical materials research. Part A 20120501

• Central nervous system lesions due to juvenile myelomonocytic leukemia progressed in a boy undergoing first line chemotherapy.

  International journal of hematology 20120501

• High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment.

  Alimentary pharmacology & therapeutics 20120501

• Azathioprine in the treatment of autoimmune blistering diseases.

  Immunology and allergy clinics of North America 20120501

• A child with pulmonary and liver Langerhans'-cell histiocytosis.

  Chinese medical journal 20120501

• [The effect of early immunosuppressive therapy on the rate of resections performed in patients with Chron's disease, in Veszprém county, Hungary, a population-based cohort study].

  Orvosi hetilap 20120408

• Tracking multiplex drugs and their dynamics in living cells using the label-free surface-enhanced Raman scattering technique.

  Molecular pharmaceutics 20120402

• Multivariate models to detect genomic signatures for a class of drugs: application to thiopurines pharmacogenomics.

  The pharmacogenomics journal 20120401

• Polymorphism of ITPA 94C>A and risk of adverse effects among patients with acute lymphoblastic leukaemia treated with 6-mercaptopurine.

  Journal of clinical pharmacy and therapeutics 20120401

• Unexpected pancytopenia following treatment of acute lymphoblastic leukemia.

  American journal of hematology 20120401

• Autoimmune cholecystitis.

  Journal of pediatric gastroenterology and nutrition 20120401

• Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia.

  European journal of clinical pharmacology 20120401

• Has there been a change in the natural history of Crohn's disease? Surgical rates and medical management in a population-based inception cohort from Western Hungary between 1977-2009.

  The American journal of gastroenterology 20120401

• Endoscopic ultrasound for perianal Crohn's disease: disease and fistula characteristics, and impact on therapy.

  Journal of Crohn's & colitis 20120401

• Effect of an anti-thyroid drug, 2,8-Dimercapto-6-hydroxy purine on reproduction in male rats.

  Pakistan journal of pharmaceutical sciences 20120401

• Langerhans cell histiocytosis with perianal localization.

  Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 20120401

• Real-time monitoring of glutathione-triggered thiopurine anticancer drug release in live cells investigated by surface-enhanced Raman scattering.

  Analytical chemistry 20120306

• Mercaptopurine-induced hypersensitivity febrile reaction in patient with acute promyelocytic leukemia.

  Leukemia & lymphoma 20120301

• Managing chronic disease in Ireland: hospital admission rates and clinical outcomes in a large ulcerative colitis population.

  Irish journal of medical science 20120301

• CDA deficiency as a possible culprit for life-threatening toxicities after cytarabine plus 6-mercaptopurine therapy: pharmacogenetic investigations.

  Pharmacogenomics 20120301

• Simultaneous quantification of eleven thiopurine nucleotides by liquid chromatography-tandem mass spectrometry.

  Analytical chemistry 20120207

• Normal response to vaccines in inflammatory bowel disease patients treated with thiopurines.

  Inflammatory bowel diseases 20120201

• Thiopurines prevent advanced colorectal neoplasia in patients with inflammatory bowel disease.

  Gut 20120201

• Use of thiopurines in the treatment of inflammatory bowel disease is associated with an increased risk of non-melanoma skin cancer in an at-risk population: a cohort study.

  Journal of gastroenterology and hepatology 20120201

• Results of the APML3 trial incorporating all-trans-retinoic acid and idarubicin in both induction and consolidation as initial therapy for patients with acute promyelocytic leukemia.

  Haematologica 20120201

• Overexpression of P-glycoprotein induces acquired resistance to imatinib in chronic myelogenous leukemia cells.

  Chinese journal of cancer 20120201

• Why thiopurine metabolites are relevant.

  Alimentary pharmacology & therapeutics 20120201

• 6-Mercaptopurine transport in human lymphocytes: correlation with drug-induced cytotoxicity.

  Journal of digestive diseases 20120201

• Risk of non-melanoma skin cancer with thiopurine use in inflammatory bowel disease.

  Journal of gastroenterology and hepatology 20120201

• Hepatotoxicity associated with 6-methyl mercaptopurine formation during azathioprine and 6-mercaptopurine therapy does not occur on the short-term during 6-thioguanine therapy in IBD treatment.

  Journal of Crohn's & colitis 20120201

• A randomized comparison of modified intermediate-dose Ara-C versus high-dose ara-c in post-remission therapy for acute myeloid leukemia.

  Anticancer research 20120201

• 6-mercaptopurine influences TPMT gene transcription in a TPMT gene promoter variable number of tandem repeats-dependent manner.

  Pharmacogenomics 20120201

• [Two cases of thiopurine-induced acute pancreatitis in inflammatory bowel disease].

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20120201

• [Guidelines for the management of Crohn's disease].

  The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20120201

• Role of base-excision repair in the treatment of childhood acute lymphoblastic leukaemia with 6-mercaptopurine and high doses of methotrexate.

  Mutation research 20120124

• Liquid chromatography-tandem mass spectrometry quantification of 6-thioguanine in DNA using endogenous guanine as internal standard.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120115

• Pneumocystis jiroveci pneumonia prophylaxis during maintenance therapy influences methotrexate/6-mercaptopurine dosing but not event-free survival for childhood acute lymphoblastic leukemia.

  European journal of haematology 20120101

• UVA photosensitization of thiopurines and skin cancer in organ transplant recipients.

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20120101

• Inherited prothrombotic risk factors in Turkish children with acute lymphoblastic leukemia: significance of concomitant genetic mutation.

  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20120101

• Evaluation of a group-based behavioral intervention to promote adherence in adolescents with inflammatory bowel disease.

  European journal of gastroenterology & hepatology 20120101

• Outcome predictors for thiopurine maintenance therapy in patients with Crohn's disease.

  Digestive diseases and sciences 20120101

• Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reduction.

  Digestive diseases and sciences 20120101

• Intrauterine exposure to thiopurines.

  Reproductive toxicology (Elmsford, N.Y.) 20120101

• [A case of primary colon amyloidosis presenting as hematochezia].

  The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20120101

• Infection from an exfoliating primary tooth in a child with severe neutropenia: a case report.

  Pediatric dentistry 20120101

• Population analysis of pharmacogenetic polymorphisms related to acute lymphoblastic leukemia drug treatment.

  Disease markers 20120101

• Combination therapy with adalimumab plus intensive granulocyte and monocyte adsorptive apheresis induced clinical remission in a Crohn's disease patient with the loss of response to scheduled adalimumab maintenance therapy: a case report.

  Internal medicine (Tokyo, Japan) 20120101

• Characterization of 6-mercaptopurine binding site on human alpha1-acid glycoprotein (orosomucoid) using molecular docking.

  Acta poloniae pharmaceutica 20120101

• Thiopurine S-methyltransferase phenotype-genotype correlation in children with acute lymphoblastic leukemia.

  Acta poloniae pharmaceutica 20120101

• Study of drug metabolism by xanthine oxidase.

  International journal of molecular sciences 20120101

• 6-Mercaptopurine-induced histopathological changes and xanthine oxidase expression in rat placenta.

  The Journal of toxicological sciences 20120101

• A validated HPLC method for the monitoring of thiopurine metabolites in whole blood in paediatric patients with inflammatory bowel disease.

  International journal of immunopathology and pharmacology 20120101

• Toxicity of azathioprine: why and when? analysis of the prevalence of polymorphism in Joinville, SC, Brazil.

  Arquivos de gastroenterologia 20120101

• Pharmacogenetics, cost of genotyping, and guidelines for individualizing therapy with mercaptopurine in pediatric acute lymphoblastic leukemia.

  Pediatric blood & cancer 20111215

• [FAQs in chronic inflammatory bowel diseases. This way your patient stays in remission].

  MMW Fortschritte der Medizin 20111208

• Use of thiopurine testing in the management of inflammatory bowel diseases in clinical practice: a worldwide survey of experts.

  Inflammatory bowel diseases 20111201

• Role of thiopurine and anti-TNF therapy in lymphoma in inflammatory bowel disease.

  The American journal of gastroenterology 20111201

• Mucosal healing for predicting clinical outcome in patients with ulcerative colitis using thiopurines in monotherapy.

  European journal of internal medicine 20111201

• Allopurinol enhances the activity of hypoxanthine-guanine phosphoribosyltransferase in inflammatory bowel disease patients during low-dose thiopurine therapy: preliminary data of an ongoing series.

  Nucleosides, nucleotides & nucleic acids 20111201

• Birth outcome in women with ulcerative colitis and Crohn's disease, and pharmacoepidemiological aspects of anti-inflammatory drug therapy.

  Danish medical bulletin 20111201

• Synthesis of pro-prodrugs L-lysine based for 5-aminosalicylic acid and 6-mercaptopurine colon specific release.

  International journal of pharmaceutics 20111128

• Surgical resection in Crohn's disease: is immunosuppressive medication associated with higher postoperative infection rates?

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20111101

• Thiopurine methyltransferase polymorphisms and mercaptopurine tolerance in Turkish children with acute lymphoblastic leukemia.

  Cancer chemotherapy and pharmacology 20111101

• Association of Crohn's disease, thiopurines, and primary epstein-barr virus infection with hemophagocytic lymphohistiocytosis.

  The Journal of pediatrics 20111101

• The transfer of 6-mercaptopurine in the dually perfused human placenta.

  Reproductive toxicology (Elmsford, N.Y.) 20111101

• Evaluating the use of metabolite measurement in children receiving treatment with a thiopurine.

  Alimentary pharmacology & therapeutics 20111101

• Thiopurine metabolites and TPMT activity measurement in inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20111101

• 6-Mercaptopurine: an effective drug in the management of advanced cutaneous T-cell lymphoma.

  Cutis 20111101

• Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease.

  World journal of gastroenterology 20111007

• Thiopurine S-methyltransferase (TPMT) polymorphisms in children with acute lymphoblastic leukemia, and the need for reduction or cessation of 6-mercaptopurine doses during maintenance therapy: the Polish multicenter analysis.

  Pediatric blood & cancer 20111001

• Augmented therapy improves outcome for pediatric high risk acute lymphocytic leukemia: results of Children's Oncology Group trial P9906.

  Pediatric blood & cancer 20111001

• Individually tailored treatment of medication nonadherence.

  Journal of pediatric gastroenterology and nutrition 20111001

• Mesenchymal stromal cell function is not affected by drugs used in the treatment of inflammatory bowel disease.

  Cytotherapy 20111001

• Individualized toxicity-titrated 6-mercaptopurine increments during high-dose methotrexate consolidation treatment of lower risk childhood acute lymphoblastic leukaemia. A Nordic Society of Paediatric Haematology and Oncology (NOPHO) pilot study.

  British journal of haematology 20111001

• Thiopurine metabolite measurement - not for everyone.

  Alimentary pharmacology & therapeutics 20111001

• Splenic littoral cell hemangioendothelioma in a patient with Crohn's disease previously treated with immunomodulators and anti-TNF agents: a rare tumor linked to deep immunosuppression.

  The American journal of gastroenterology 20111001

• Thiopurine immunomodulators in ulcerative colitis: moving forward with current evidence.

  Current drug targets 20110901

• 6-Mercaptopurine transport by equilibrative nucleoside transporters in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBTs.

  Journal of pharmaceutical sciences 20110901

• Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients.

  Alimentary pharmacology & therapeutics 20110901

• Risk of malignant lymphoma in patients with inflammatory bowel diseases: a Dutch nationwide study.

  Inflammatory bowel diseases 20110901

• Minimally invasive surface-enhanced Raman scattering detection with depth profiles based on a surface-enhanced Raman scattering-active acupuncture needle.

  Analytical chemistry 20110815

• Common misconceptions about 5-aminosalicylates and thiopurines in inflammatory bowel disease.

  World journal of gastroenterology 20110814

• A cost effectiveness analysis of thiopurine methyltransferase testing for guiding 6-mercaptopurine dosing in children with acute lymphoblastic leukemia.

  Pediatric blood & cancer 20110801

• Varicella zoster meningoradiculitis in Crohn's disease treated with 6-mercaptopurine.

  Inflammatory bowel diseases 20110801

• Steroid dependency and pediatric inflammatory bowel disease in the era of immunomodulators--a population-based study.

  Inflammatory bowel diseases 20110801

• Reversible bone marrow necrosis after all-trans retinoic acid induction therapy for acute promyelocytic leukaemia.

  Pathology 20110801

• 6-Mercaptopurine complexes with silver and gold ions: anti-tuberculosis and anti-cancer activities.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110801

• The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells.

  Biochemical and biophysical research communications 20110722

• Current treatment of ulcerative colitis.

  World journal of gastroenterology 20110721

• A microchip electrophoresis strategy with online labeling and chemiluminescence detection for simultaneous quantification of thiol drugs.

  Journal of pharmaceutical and biomedical analysis 20110715

• Tacrolimus therapy as an alternative to thiopurines for maintaining remission in patients with refractory ulcerative colitis.

  Journal of clinical gastroenterology 20110701

• Detection of thiopurine methyltransferase activity in lysed red blood cells by means of lab-on-a-chip surface enhanced Raman spectroscopy (LOC-SERS).

  Analytical and bioanalytical chemistry 20110701

• Pre-analytic and analytic sources of variations in thiopurine methyltransferase activity measurement in patients prescribed thiopurine-based drugs: A systematic review.

  Clinical biochemistry 20110701

• 'Tac'kling a difficult problem: using tacrolimus to maintain remission in ulcerative colitis.

  Journal of clinical gastroenterology 20110701

• Inflammatory bowel disease therapy: current state-of-the-art.

  Current opinion in gastroenterology 20110701

• Strength capacity in young patients who are receiving maintenance therapy for acute lymphoblastic leukemia: a case-control study.

  Clinics (Sao Paulo, Brazil) 20110701

• Insight into the 6-thiopurine-mediated termination of the invasive motility of tumor cells derived from inflammatory breast cancer.

  Biochemistry 20110628

• Quantum mechanical/molecular mechanical molecular dynamics and free energy simulations of the thiopurine S-methyltransferase reaction with 6-mercaptopurine.

  The journal of physical chemistry. B 20110623

• Assessment of thiopurine S-methyltransferase activity in patients prescribed thiopurines: a systematic review.

  Annals of internal medicine 20110621

• Successful treatment of relapsed and refractory extramedullary acute promyelocytic leukemia with tamibarotene.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110620

• Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease.

  Inflammatory bowel diseases 20110601

• Optimizing thiopurine therapy in inflammatory bowel disease.

  Inflammatory bowel diseases 20110601

• Thiopurine derivatives containing triazole and steroid: synthesis, antimalarial and antileishmanial activities.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110601

• Eruptive benign melanocytic naevi during immunosuppressive therapy in a Crohn's disease patient.

  Inflammatory bowel diseases 20110601

• Clinical course of Crohn's disease following treatment of lymphoma.

  Inflammatory bowel diseases 20110601

• Meta-analysis of randomised trials comparing thiopurines in childhood acute lymphoblastic leukaemia.

  Leukemia 20110601

• Severe muscular weakness as an isolated symptom of azathioprine hypersensitivity.

  Inflammatory bowel diseases 20110601

• Effects of methylenetetrahydrofolate reductase gene polymorphisms on toxicities during consolidation therapy in pediatric acute lymphoblastic leukemia in a Chinese population.

  Leukemia & lymphoma 20110601

• Female patients suffering from inflammatory bowel diseases are treated less frequently with immunosuppressive medication and have a higher disease activity: a subgroup analysis of a large multi-centre, prospective, internet-based study.

  Journal of Crohn's & colitis 20110601

• The effects of azathioprine on birth outcomes in women with inflammatory bowel disease (IBD).

  Journal of Crohn's & colitis 20110601

• The 6-MP versus placebo clinical trial in acute leukemia.

  Clinical trials (London, England) 20110601

• Outcome following thiopurine use in children with ulcerative colitis: a prospective multicenter registry study.

  The American journal of gastroenterology 20110501

• Risk of nonmelanoma skin cancer in patients with inflammatory bowel disease who use thiopurines is not increased.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20110501

• Azathioprine and mercaptopurine: lymphoma.

  Prescrire international 20110501

• Bayesian analysis for monotone hazard ratio.

  Lifetime data analysis 20110401

• 6-Mercaptopurine reverses experimental vasospasm and alleviates the production of endothelins in NO-independent mechanism-a laboratory study.

  Acta neurochirurgica 20110401

• [Plasmacytoid dendritic cell tumor].

  Actas dermo-sifiliograficas 20110401

• Long-term efficacy and safety of cyclosporine as a rescue therapy in acute, steroid-refractory severe ulcerative colitis: switching to infliximab is more effective than treating with concomitant immunomodulators.

  Journal of clinical gastroenterology 20110401

• Long-term results of AIEOP-8805 protocol for acute B-cell lymphoblastic leukemia of childhood.

  Pediatric blood & cancer 20110401

• Determinants of mercaptopurine toxicity in paediatric acute lymphoblastic leukemia maintenance therapy.

  British journal of clinical pharmacology 20110401

• Efficacy of immunosuppressive therapy for inflammatory bowel disease: a systematic review and meta-analysis.

  The American journal of gastroenterology 20110401

• Pyoderma gangrenosum in inflammatory bowel disease: the experience at Mater Health Services' Adult Hospital 1998-2009.

  Journal of Crohn's & colitis 20110401

• Antibacterial activity and phytochemical study of six medicinal plants used in Benin.

  Pakistan journal of biological sciences : PJBS 20110401

• Treatment of acute promyelocytic leukaemia in the Jehovah's Witness population.

  Annals of hematology 20110301

• The role of standard-dose cytarabine in children with acute promyelocytic leukemia: a single-center experience.

  Journal of pediatric hematology/oncology 20110301

• Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing.

  Clinical pharmacology and therapeutics 20110301

• Increased sensitivity to thiopurines in methylthioadenosine phosphorylase-deleted cancers.

  Molecular cancer therapeutics 20110301

• Severe hypoglycemic seizures in a child receiving 6-mercaptopurine.

  Journal of pediatric hematology/oncology 20110301

• Insulin infusion to treat severe hypertriglyceridemia associated with pegaspargase therapy: a case report.

  Journal of pediatric hematology/oncology 20110301

• Cyclosporine is safe and effective in patients with severe ulcerative colitis.

  Journal of clinical gastroenterology 20110201

• Prevention and treatment of postoperative Crohn's disease recurrence: an update for a new decade.

  Current gastroenterology reports 20110201

• Pregnancy outcome in patients with inflammatory bowel disease treated with thiopurines: cohort from the CESAME Study.

  Gut 20110201

• Assessment of non-cirrhotic portal hypertension associated with thiopurine therapy in inflammatory bowel disease.

  Journal of Crohn's & colitis 20110201

• Immunosuppressive therapy in children.

  Journal of the Indian Medical Association 20110201

• Erythroblastic islands.

  Blood 20110106

• The relationship between fetal growth restriction and small placenta in 6-mercaptopurine exposed rat.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20110101

• Infliximab and/or azathioprine in the treatment of Crohn's disease-like complications after IPAA.

  Diseases of the colon and rectum 20110101

• Allopurinol might improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio.

  Journal of gastroenterology and hepatology 20110101

• Azathioprine metabolite measurements are not useful in following treatment of autoimmune hepatitis in Alaska Native and other non-Caucasian people.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20110101

• [Influence of exogeneous proteins on mutagenic process].

  TSitologiia i genetika 20110101

• Successful treatment of adult onset Langerhans cell histiocytosis with multi-drug combination therapy.

  Internal medicine (Tokyo, Japan) 20110101

• Adverse events of thiopurine immunomodulators in patients with inflammatory bowel disease.

  Gastroenterologia y hepatologia 20110101

• Outcome of combination antiviral therapy in chronic hepatitis C virus infection during therapy of acute lymphoblastic leukemia.

  Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 20110101

• Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial.

  Lancet (London, England) 20101211

• Frequency of TPMT alleles in Indian patients with acute lymphatic leukemia and effect on the dose of 6-mercaptopurine.

  Medical oncology (Northwood, London, England) 20101201

• Combination biological and surgical therapy in an adolescent presenting with highly destructive perianal Crohn disease.

  Journal of pediatric gastroenterology and nutrition 20101201

• A single-center experience with methotrexate after thiopurine therapy in pediatric Crohn disease.

  Journal of pediatric gastroenterology and nutrition 20101201

• Ecto-5'-nucleotidase and thiopurine cellular circulation: association with cytotoxicity.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Preparing the patient for immunosuppressive therapy.

  Current gastroenterology reports 20101201

• Thiopurines in Crohn's disease, is there something new?

  Expert opinion on drug metabolism & toxicology 20101201

• Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease.

  Journal of Crohn's & colitis 20101201

• Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710.

  Blood 20101111

• Azathioprine-induced hypersensitivity hepatitis: tolerance to 6-mercaptopurine.

  Inflammatory bowel diseases 20101101

• Childhood acute lymphoblastic leukemia in Turkey: factors influencing treatment and outcome: a single center experience.

  Journal of pediatric hematology/oncology 20101101

• Allopurinol-thiopurine combination therapy in inflammatory bowel disease: are there genetic clues to this puzzle?

  Pharmacogenomics 20101101

• Hepatosplenic T-cell lymphoma and inflammatory bowel disease.

  Journal of Crohn's & colitis 20101101

• A prospective evaluation of the impact of allopurinol in pediatric and adult IBD patients with preferential metabolism of 6-mercaptopurine to 6-methylmercaptopurine.

  Journal of Crohn's & colitis 20101101

• Adherence of gastroenterologists to European Crohn's and Colitis Organisation consensus on ulcerative colitis: a real-life survey in Spain.

  Journal of Crohn's & colitis 20101101

• Long-term efficacy of adalimumab in paediatric Crohn's disease patients naïve to other anti-TNF therapies.

  Journal of Crohn's & colitis 20101101

• Usefulness of the measurement of azathioprine metabolites in the assessment of non-adherence.

  Journal of Crohn's & colitis 20101101

• [A successful case of tanshinone II A treatment for relapsed acute promyelocytic leukemia after maintainance therapy of all-trans retinoic acid and arsenic trioxide].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20101101

• Brief report: Barriers to treatment adherence in pediatric inflammatory bowel disease.

  Journal of pediatric psychology 20101001

• Merkel cell carcinoma metastatic to the thyroid gland: Aspiration findings and differential diagnosis.

  Diagnostic cytopathology 20101001

• The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease.

  Journal of gastroenterology 20101001

• Allopurinol salvage therapy in pediatric overlap autoimmune hepatitis-primary sclerosing cholangitis with 6-MMP toxicity.

  Journal of pediatric gastroenterology and nutrition 20101001

• Renal cell carcinoma and acute promyelocytic leukemia: a nonrandom association?

  American journal of hematology 20101001

• Combination of the histone deacetylase inhibitor valproic acid with oral hydroxyurea or 6-mercaptopurin can be safe and effective in patients with advanced acute myeloid leukaemia--a report of five cases.

  Hematology (Amsterdam, Netherlands) 20101001

• Monitoring 6-thioguanine nucleotide concentrations in Japanese children and adolescents with inflammatory bowel disease.

  Journal of gastroenterology and hepatology 20101001

• Hepatosplenic T-cell lymphoma in inflammatory bowel disease: a possible thiopurine-induced chromosomal abnormality.

  The American journal of gastroenterology 20101001

• Thiopurine therapy in inflammatory bowel disease.

  Expert review of gastroenterology & hepatology 20101001

• Combination of thiopurines and allopurinol: adverse events and clinical benefit in IBD.

  Journal of Crohn's & colitis 20101001

• Tolerability and usefulness of mercaptopurine in azathioprine-intolerant Japanese patients with ulcerative colitis.

  Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 20101001

• Substrate orientation and catalytic specificity in the action of xanthine oxidase: the sequential hydroxylation of hypoxanthine to uric acid.

  The Journal of biological chemistry 20100903

• Bone marrow suppression in the setting of normal thiopurine methyltransferase phenotype testing.

  Clinical pediatrics 20100901

• Thiopurine pathway.

  Pharmacogenetics and genomics 20100901

• The impact of high-dose methotrexate on intracellular 6-mercaptopurine disposition during interval therapy of childhood acute lymphoblastic leukemia.

  Cancer chemotherapy and pharmacology 20100901

• Treatment-associated acute myeloid leukemia in a patient with Crohn's disease on 6-mercaptopurine.

  Inflammatory bowel diseases 20100901

• Thiopurine therapy in inflammatory bowel disease patients: analyses of two 8-year intercept cohorts.

  Inflammatory bowel diseases 20100901

• Natural history of Crohn's disease in a population-based cohort from Cardiff (1986-2003): a study of changes in medical treatment and surgical resection rates.

  Gut 20100901

• Outcomes of pregnancies fathered by inflammatory bowel disease patients exposed to thiopurines.

  The American journal of gastroenterology 20100901

• [Remission of ulcerative colitis after appendectomy: a case report].

  The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20100901

• CNS relapse in acute promyeloctyic leukemia.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100820

• DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma.

  Cancer chemotherapy and pharmacology 20100801

• Thiopurine maintenance therapy for ulcerative colitis: the clinical significance of monitoring 6-thioguanine nucleotide.

  Inflammatory bowel diseases 20100801

• Thiopurine S-methyltransferase gene polymorphism and 6-mercaptopurine dose intensity in Indian children with acute lymphoblastic leukemia.

  Leukemia research 20100801

• Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis.

  Inflammatory bowel diseases 20100801

• 6-mercaptopurine inhibits atherosclerosis in apolipoprotein e*3-leiden transgenic mice through atheroprotective actions on monocytes and macrophages.

  Arteriosclerosis, thrombosis, and vascular biology 20100801

• 6-Mercaptopurine exerts an immunomodulatory and neuroprotective effect on permanent focal cerebral occlusion in rats.

  Acta neurochirurgica 20100801

• Monitoring of azathioprine metabolites in pediatric patients with autoimmune hepatitis.

  Therapeutic drug monitoring 20100801

• Immunosuppressive treatments in Crohn's disease induce myelodysplasia and leukaemia.

  American journal of hematology 20100801

• Randomized trial to compare LSA2L2-type maintenance therapy to daily 6-mercaptopurine and weekly methotrexate with vincristine and dexamethasone pulse for children with acute lymphoblastic leukemia.

  Pediatric blood & cancer 20100801

• Langerhans cell histiocytosis in a child with non-Hodgkin lymphoma.

  Journal of pediatric hematology/oncology 20100801

• 6-Mercaptopurine, monocytes, and atherosclerosis.

  Arteriosclerosis, thrombosis, and vascular biology 20100801

• Complete paraplegia after nelarabine treatment in a T-cell acute lymphoblastic leukemia adult patient.

  American journal of hematology 20100801

• IBD: Switching metabolism-can two drugs be better than one?

  Nature reviews. Gastroenterology & hepatology 20100801

• Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine.

  Chemico-biological interactions 20100730

• Thiopurine S-methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease.

  World journal of gastroenterology 20100707

• A 30-month-old child with acute renal failure due to primary renal cytotoxic T-cell lymphoma.

  The American journal of surgical pathology 20100701

• Influence of 5-aminosalicylic acid on 6-thioguanosine phosphate metabolite levels: a prospective study in patients under steady thiopurine therapy.

  British journal of pharmacology 20100701

• Postoperative Crohn's disease: how can we prevent it?

  Expert review of clinical immunology 20100701

• Use of immunomodulators and biologic therapies in children with inflammatory bowel disease.

  Expert review of clinical immunology 20100701

• [A case of hemophagocytic syndrome in an ulcerative colitis patient].

  The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20100701

• Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease.

  The Cochrane database of systematic reviews 20100616

• Using adaptive model predictive control to customize maintenance therapy chemotherapeutic dosing for childhood acute lymphoblastic leukemia.

  Journal of theoretical biology 20100607

• Response to medical treatment in patients with Crohn's disease: the role of NOD2/CRAD15, disease phenotype, and age of diagnosis.

  Digestive diseases and sciences 20100601

• Health-related quality of life of youth with inflammatory bowel disease: a comparison with published data using the PedsQL 4.0 generic core scales.

  Inflammatory bowel diseases 20100601

• Azathioprine or mercaptopurine-induced acute pancreatitis is not a disease-specific phenomenon.

  Alimentary pharmacology & therapeutics 20100601

• Limited stability of thiopurine metabolites in blood samples: relevant in research and clinical practise.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601

• Central nervous system complications during treatment of acute lymphoblastic leukemia in a single pediatric institution.

  Leukemia & lymphoma 20100601

• Novel strategies in the thiopurine treatment of inflammatory bowel disease.

  Nucleosides, nucleotides & nucleic acids 20100601

• How should thiopurine treatment be monitored?--methodological aspects.

  Nucleosides, nucleotides & nucleic acids 20100601

• Subcutaneous panniculitis-like T-cell lymphoma in a 19 month-old boy: a case report.

  Collegium antropologicum 20100601

• Impact of concomitant immunomodulator use on long-term outcomes in patients receiving scheduled maintenance infliximab.

  Digestive diseases and sciences 20100501

• The impact of thiopurines on the risk of surgical recurrence in patients with Crohn's disease after first intestinal surgery.

  The American journal of gastroenterology 20100501

• Prediction of 6-thioguanine nucleotides levels in Japanese patients with inflammatory bowel diseases during long-term thiopurine administration.

  Scandinavian journal of gastroenterology 20100501

• 6-Mercaptopurine attenuates adhesive molecules in experimental vasospasm.

  Acta neurochirurgica 20100501

• Desensitization of patients with allergic reactions to immunosuppressives in the treatment of inflammatory bowel disease.

  Expert opinion on drug safety 20100501

• Prospective study of hemostatic alterations in children with acute lymphoblastic leukemia.

  American journal of hematology 20100501

• Neurological complications during treatment of childhood cancer: mind Wernicke encephalopathy.

  Pediatric hematology and oncology 20100501

• Benefits of the intermittent use of 6-mercaptopurine and methotrexate in maintenance treatment for low-risk acute lymphoblastic leukemia in children: randomized trial from the Brazilian Childhood Cooperative Group--protocol ALL-99.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100410

• Oral 6-mercaptopurine versus oral 6-thioguanine and veno-occlusive disease in children with standard-risk acute lymphoblastic leukemia: report of the Children's Oncology Group CCG-1952 clinical trial.

  Blood 20100408

• Design and in vitro evaluation of branched peptide conjugates: turning nonspecific cytotoxic drugs into tumor-selective agents.

  ChemMedChem 20100406

• Central nervous system involvement at the time of presentation in acute promyelocytic leukemia.

  Pediatric blood & cancer 20100401

• Prospective bone ultrasound patterns during childhood acute lymphoblastic leukemia treatment.

  Bone 20100401

• Ongoing remission after intensive ALL-type chemotherapy in pediatric intestinal T-cell lymphoma.

  Pediatric blood & cancer 20100401

• Pancreatitis in inflammatory bowel diseases.

  Journal of clinical gastroenterology 20100401

• The degree of myelosuppression during maintenance therapy of adolescents with B-lineage intermediate risk acute lymphoblastic leukemia predicts risk of relapse.

  Leukemia 20100401

• Hepatosplenic T-cell lymphoma in a young man with Crohn's disease: case report and literature review.

  Clinical lymphoma, myeloma & leukemia 20100401

• [Tolerability of 6-mercaptopurine in children with acute lymphoblastic leukemia].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20100401

• Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20100301

• Significance of myeloid antigen expression in precursor T lymphoblastic lymphoma.

  Chinese journal of cancer 20100301

• Juvenile myelomonocytic leukemia with PTPN11 mutation in a 23-month-old girl.

  Collegium antropologicum 20100301

• 13C chemical shift tensors in hypoxanthine and 6-mercaptopurine: effects of substitution, tautomerism, and intermolecular interactions.

  The journal of physical chemistry. A 20100204

• Toxic non-resorptive internal hydrocephalus as a result of haemorrhagic ventriculitis during induction chemotherapy of Bcr-Abl positive acute lymphoblastic leukaemia.

  Annals of hematology 20100201

• Algorithms outperform metabolite tests in predicting response of patients with inflammatory bowel disease to thiopurines.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20100201

• Central variant of posterior reversible encephalopathy syndrome in systemic lupus erythematosus: new associations?

  Lupus 20100201

• Correlation of genotypes for thiopurine methyltransferase and inosine triphosphate pyrophosphatase with long-term clinical outcomes in Korean patients with inflammatory bowel diseases during treatment with thiopurine drugs.

  Journal of human genetics 20100201

• 'I am older, not elderly,' said the patient with acute myeloid leukemia.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100201

• Oedema and Crohn's disease.

  The Netherlands journal of medicine 20100201

• Thiopurine S-methyltransferase genotype and the use of thiopurines in paediatric inflammatory bowel disease Greek patients.

  Journal of clinical pharmacy and therapeutics 20100201

• Mercaptopurine rescue after azathioprine-induced liver injury in inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20100101

• Flow injection chemiluminescence determination of 6-mercaptopurine based on a new system of potassium permanganate-thioacetamide-sodium hexametaphosphate.

  Luminescence : the journal of biological and chemical luminescence 20100101

• MTHFR and TYMS genotypes influence TPMT activity and its differential modulation in males and females.

  Clinical biochemistry 20100101

• Pro-inflammatory and pro-coagulant properties of 6-thioguanine and 6-mercaptopurine: implications for their potential role in the development of sinusoidal obstruction syndrome.

  Leukemia & lymphoma 20100101

• Methylene tetrahydrofolate reductase gene polymorphism in Egyptian children with acute lymphoblastic leukemia.

  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20100101

• Cutaneous xanthogranulomas, hepatosplenomegaly, anemia, and thrombocytopenia as presenting signs of juvenile myelomonocytic leukemia.

  American journal of clinical dermatology 20100101

• Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status.

  Expert opinion on drug safety 20100101

• Mercaptopurine-induced fever: hypersensitivity reaction in a patient with acute lymphoblastic leukemia.

  Pharmacotherapy 20100101

• Clinical profile, treatment, and visual outcome of ampiginous choroiditis.

  Ocular immunology and inflammation 20100101

• [Immunosuppressive therapy update 2010 for ANCA-associated glomerulonephritis and intractable nephrotic syndrome].

  Nihon Jinzo Gakkai shi 20100101

• Influences of thiopurine methyltransferase genotype and activity on thiopurine-induced leukopenia in Korean patients with inflammatory bowel disease: a retrospective cohort study.

  Journal of clinical gastroenterology 20100101

• [Therapeutic drug monitoring of 6-thioguanine nucleotides in paediatric acute lymphoblastic leukaemia: interest and limits].

  Therapie 20100101

• Usefulness of thiopurine methyltransferase and thiopurine metabolite analysis in clinical practice in patients with inflammatory bowel diseases.

  Acta gastro-enterologica Belgica 20100101

• [A case of the association of acute lymphoblastic lymphoma with active tuberculosis in the child: a Malian case].

  Le Mali medical 20100101

• Microprocessor in controlled transdermal drug delivery of anti-cancer drugs.

  Journal of materials science. Materials in medicine 20091201

• Peripheral neuropathy with infliximab therapy in inflammatory bowel disease.

  Inflammatory bowel diseases 20091201

• Captopril and 6-mercaptopurine: whose SH possesses higher antioxidant ability?

  European journal of medicinal chemistry 20091201

• [Significant changes of pharmacotherapy in gastroenterological rehabilitation of Crohn's disease].

  Die Rehabilitation 20091201

• Outcome and haemato-toxicity of two chemotherapy regimens for childhood non-Hodgkin's lymphoma in a Kenyan hospital.

  East African medical journal 20091201

• Additional chromosomal abnormalities and their prognostic significance in adult Philadelphia-positive acute lymphoblastic leukemia: with or without imatinib in chemotherapy.

  Annals of hematology 20091101

• Timing of myelosuppression during thiopurine therapy for inflammatory bowel disease: implications for monitoring recommendations.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20091101

• The development of an objective methodology to measure medication adherence to oral thiopurines in paediatric patients with acute lymphoblastic leukaemia--an exploratory study.

  European journal of clinical pharmacology 20091101

• Effects of interactions of antibacterial drugs with each other and with 6-mercaptopurine on in vitro growth of Mycobacterium avium subspecies paratuberculosis.

  The Journal of antimicrobial chemotherapy 20091101

• Patent watch. Drug metabolite claims are patentable.

  Nature reviews. Drug discovery 20091101

• The cytotoxic effects of gemtuzumab ozogamicin (mylotarg) in combination with conventional antileukemic agents by isobologram analysis in vitro.

  Anticancer research 20091101

• Prospective study of the effects of concomitant medications on thiopurine metabolism in inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20091015

• Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease.

  The Cochrane database of systematic reviews 20091007

• The race and dose of chemotherapy should be considered for optimizing maintenance therapy for acute promyelocytic leukemia.

  Leukemia research 20091001

• Adverse events associated with common therapy regimens for moderate-to-severe Crohn's disease.

  The American journal of gastroenterology 20091001

• Dose-response relationships of rat fetal skeleton variations: Relevance for risk assessment.

  Environmental research 20091001

• The effect of active hexose correlated compound in modulating cytosine arabinoside-induced hair loss, and 6-mercaptopurine- and methotrexate-induced liver injury in rodents.

  Cancer epidemiology 20091001

• Inflammatory bowel diseases and management considerations: fertility and pregnancy.

  Current gastroenterology reports 20091001

• Efficacy of methotrexate in Crohn's disease and ulcerative colitis patients unresponsive or intolerant to azathioprine /mercaptopurine.

  Alimentary pharmacology & therapeutics 20090915

• Emerging treatments for complex perianal fistula in Crohn's disease.

  World journal of gastroenterology 20090914

• Autoimmune pancreatitis with multiorgan involvement. A case of pericardial involvement.

  JOP : Journal of the pancreas 20090904

• Anaplastic large cell lymphoma of the ovary in a pediatric patient.

  Journal of pediatric hematology/oncology 20090901

• Mutagenicity and potential carcinogenicity of thiopurine treatment in patients with inflammatory bowel disease.

  Cancer research 20090901

• Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia.

  Blood 20090813

• Azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in Crohn's disease: a meta-analysis.

  The American journal of gastroenterology 20090801

• Use of azathioprine and 6MP in postoperative Crohn's: changing natural history or just along for the ride?

  The American journal of gastroenterology 20090801

• Individualization of thiopurine therapy: thiopurine S-methyltransferase and beyond.

  Pharmacogenomics 20090801

• Hydrogen bonding and stacking pi-pi interactions in solid 6-thioguanine and 6-mercaptopurine (antileukemia and antineoplastic drugs) studied by NMR-NQR double resonance spectroscopy and density functional theory.

  The journal of physical chemistry. A 20090730

• Meta-analysis: the efficacy of azathioprine and mercaptopurine in ulcerative colitis.

  Alimentary pharmacology & therapeutics 20090701

• Thiopurine methyltransferase and thiopurine metabolite testing in patients with inflammatory bowel disease who are taking thiopurine drugs.

  Pharmacogenomics 20090701

• [Prophylaxis and treatment of modified BFM-90 regimen for lymphoblastic lymphoma in children and adolescents accompanied with infection].

  Ai zheng = Aizheng = Chinese journal of cancer 20090701

• Treating childhood acute lymphoblastic leukemia without cranial irradiation.

  The New England journal of medicine 20090625

• Prognostic significance of CD20 expression in adults with de novo precursor B-lineage acute lymphoblastic leukemia.

  Blood 20090618

• S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts.

  Biochemical pharmacology 20090615

• Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study.

  Blood 20090611

• On the malignant potential of thiopurine therapy.

  Blood 20090611

• Effective treatment of advanced-stage childhood lymphoblastic lymphoma without prophylactic cranial irradiation: results of St Jude NHL13 study.

  Leukemia 20090601

• Monitoring of thiopurine metabolites in patients with inflammatory bowel disease-what is actually measured?

  Therapeutic drug monitoring 20090601

• Fatal disseminated cytomegalovirus infection associated with infliximab and 6-mercaptopurine therapy in a child with Crohn disease.

  The Pediatric infectious disease journal 20090601

• Acquired acute myelogenous leukemia after therapy for acute promyelocytic leukemia with t(15;17): a case report and review of the literature.

  Puerto Rico health sciences journal 20090601

• Serendipity-methotrexate and 6-mercaptopurine for continuation therapy for patients with acute lymphoblastic leukemia: the leukemic stem cell and beyond?

  Journal of pediatric hematology/oncology 20090601

• Oral methotrexate/6-mercaptopurine may be superior to a multidrug LSA2L2 Maintenance therapy for higher risk childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study.

  Journal of pediatric hematology/oncology 20090601

• Influenza vaccinations: should they really be encouraged for IBD patients being treated with immunosuppressives?

  Inflammatory bowel diseases 20090501

• Heterozygosity at the TPMT gene locus, augmented by mutated MTHFR gene, predisposes to 6-MP related toxicities in childhood ALL patients.

  Leukemia 20090501

• Methotrexate treatment in pediatric Crohn disease patients intolerant or resistant to purine analogues.

  Journal of pediatric gastroenterology and nutrition 20090501

• The presentation of 6-mercaptopurine overdose in ED.

  The American journal of emergency medicine 20090501

• Chemotherapy induced esophageal stricture.

  Pediatric blood & cancer 20090401

• Roles of inner blood-retinal barrier organic anion transporter 3 in the vitreous/retina-to-blood efflux transport of p-aminohippuric acid, benzylpenicillin, and 6-mercaptopurine.

  The Journal of pharmacology and experimental therapeutics 20090401

• Inflammatory bowel disease potpourri: a vignette-based discussion.

  Medicine and health, Rhode Island 20090401

• Reproductive issues in inflammatory bowel disease.

  Medicine and health, Rhode Island 20090401

• Hepatosplenic T-cell lymphoma following infliximab therapy for Crohn's disease.

  The Medical journal of Australia 20090316

• Mercaptopurine treatment should be considered in azathioprine intolerant patients with inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20090315

• 6-Thioguanine therapy in Crohn's disease--observational data in Swedish patients.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20090301

• Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study.

  Leukemia 20090301

• Distribution of TPMT risk alleles for thiopurine [correction of thioupurine] toxicity in the Israeli population.

  European journal of clinical pharmacology 20090301

• Time-course changes in neural cell apoptosis in the rat fetal brain from dams treated with 6-mercaptopurine (6-MP).

  Histology and histopathology 20090301

• [Pharmacological and pharmacogenetic study of two immunomodulators: azathioprine and 6-mercaptopurine. Strategies for preventing complications].

  Gastroenterologie clinique et biologique 20090301

• Medical therapy of IBD in 2009.

  Medicine and health, Rhode Island 20090301

• Development and validation of an HPLC method for the rapid and simultaneous determination of 6-mercaptopurine and four of its metabolites in plasma and red blood cells.

  Journal of pharmaceutical and biomedical analysis 20090220

• Pharmacogenetics--tailoring treatment for the outliers.

  The New England journal of medicine 20090219

• Novel derivatives of 6-mercaptopurine: synthesis, characterization and antiproliferative activities of S-allylthio-mercaptopurines.

  European journal of medicinal chemistry 20090201

• Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia.

  Clinical pharmacology and therapeutics 20090201

• Co-prescribing azathiopurine or 6-mercaptopurine and 5-aminosalicylate compounds in ulcerative colitis.

  Inflammatory bowel diseases 20090201

• 6-mercaptopurine as an alternative to azathioprine in azathioprine-induced hepatoxicity.

  Inflammatory bowel diseases 20090201

• The increasing complexity of mercaptopurine pharmacogenomics.

  Clinical pharmacology and therapeutics 20090201

• [Optimising azathioprine treatment: determination of thiopurine methyltransferase activity and thiopurine metabolites].

  Anales de pediatria (Barcelona, Spain : 2003) 20090201

• A new method for CE-EC determination of mercaptopurine (MP) in a PMMA biochip with on-chip gold nano-electrode ensemble (GNEE) working and decouple electrodes.

  Journal of nanoscience and nanotechnology 20090201

• [Treatment of Crohn's disease].

  Praxis 20090121

• Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease.

  The Cochrane database of systematic reviews 20090121

• Response to mercaptopurine for refractory autoimmune cytopenias in children.

  Pediatric blood & cancer 20090101

• Foot-drop: an unusual complaint in Henoch-Schönlein purpura.

  Pediatric nephrology (Berlin, Germany) 20090101

• 6-Mercaptopurine: teaching an old drug new tricks.

  Pediatric blood & cancer 20090101

• 6-Mercaptopurine (6-MP) induces cell cycle arrest and apoptosis of neural progenitor cells in the developing fetal rat brain.

  Neurotoxicology and teratology 20090101

• Poor treatment compliance in children with down syndrome and acute lymphoblastic leukemia.

  Journal of pediatric hematology/oncology 20090101

• Pharmacogenetics and pharmacogenomics of anticancer agents.

  CA: a cancer journal for clinicians 20090101

• Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment.

  Journal of gastroenterology 20090101

• 6-mercaptopurine (6-MP) induces p53-mediated apoptosis of neural progenitor cells in the developing fetal rodent brain.

  Neurotoxicology and teratology 20090101

• Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme.

  Antiviral chemistry & chemotherapy 20090101

• Severe myelosuppression following alopecia shortly after the initiation of 6-mercaptopurine in a patient with Crohn's disease.

  Internal medicine (Tokyo, Japan) 20090101

• Allele frequency of thiopurine methyltransferase and inosine triphosphate pyrophosphatase gene polymorphisms in Korean patients with inflammatory bowel diseases.

  Hepato-gastroenterology 20090101

• [P-glycoprotein functional activity in peripheral blood lymphocytes in ulcerative colitis].

  Medicina 20090101

• The future of inflammatory bowel disease care.

  Reviews in gastroenterological disorders 20090101

• Recurrent orbital myositis with radiological feature mimicking thyroid eye disease in a patient with Crohn's disease.

  Orbit (Amsterdam, Netherlands) 20090101

• The efficacy of low dose azathioprine/6-mercaptopurine in patients with inflammatory bowel disease.

  Hepato-gastroenterology 20090101

• TPMT and DPD polymorphisms: Efficient screening method for Indian patients considering taking Thiopurine and 5-FU drugs.

  Disease markers 20090101

• Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals.

  Drug metabolism and pharmacokinetics 20090101

• [Phytocorrection of structural changes in the gastrointestinal tract caused by 6-mercaptopurine].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101

• Initial clinical experience with allopurinol-thiopurine combination therapy in pediatric inflammatory bowel disease.

  Inflammatory bowel diseases 20081201

• Minimal residual disease is an important predictive factor of outcome in children with relapsed 'high-risk' acute lymphoblastic leukemia.

  Leukemia 20081201

• Population pharmacokinetic and pharmacogenetic analysis of 6-mercaptopurine in paediatric patients with acute lymphoblastic leukaemia.

  British journal of clinical pharmacology 20081201

• Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides.

  European journal of gastroenterology & hepatology 20081201

• Thiopurine S-methyltransferase (TPMT) gene polymorphism in Brazilian children with acute lymphoblastic leukemia: association with clinical and laboratory data.

  Therapeutic drug monitoring 20081201

• [Inflammatory bowel disease. If a patient with Crohn's disease remains in remission for 4 years with azathioprine (or mercaptopurine), should the drug be withdrawn?].

  Gastroenterologia y hepatologia 20081201

• Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia.

  Blood 20081115

• Influence of methylene tetrahydrofolate reductase polymorphisms and coadministration of antimetabolites on toxicity after high dose methotrexate.

  European journal of haematology 20081101

• Oral mucositis in acute lymphoblastic leukaemia: analysis of 169 paediatric patients.

  Oral diseases 20081101

• Maintenance therapy with dose-adjusted 6-mercaptopurine in idiopathic pulmonary hemosiderosis.

  Pediatric pulmonology 20081101

• The effect of thiopurine drugs on DNA methylation in relation to TPMT expression.

  Biochemical pharmacology 20081015

• Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine.

  British journal of clinical pharmacology 20081001

• Laboratory evaluation of inflammatory bowel disease.

  Current opinion in pediatrics 20081001

• What are the rules when treatment with 6-MP/AZA is started?

  Inflammatory bowel diseases 20081001

• Is it always therapeutically important to distinguish between Crohn's disease and ulcerative colitis?

  Inflammatory bowel diseases 20081001

• Complete regression of cirrhosis after immunosuppressive treatment in autoimmune hepatitis.

  Pediatrics international : official journal of the Japan Pediatric Society 20081001

• Review article: treatment algorithms to maximize remission and minimize corticosteroid dependence in patients with inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20080915

• Influence of xanthine oxidase on thiopurine metabolism in Crohn's disease.

  Alimentary pharmacology & therapeutics 20080915

• Long-term outcome of using allopurinol co-therapy as a strategy for overcoming thiopurine hepatotoxicity in treating inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20080915

• Medication adherence and quality of life in pediatric inflammatory bowel disease.

  Journal of pediatric psychology 20080901

• Predictive factors associated with immunosuppressive agent use in ulcerative colitis: a case-control study.

  Alimentary pharmacology & therapeutics 20080901

• Monitoring 6-thioguanine nucleotide concentrations in Japanese patients with inflammatory bowel disease.

  Journal of gastroenterology and hepatology 20080901

• Thiopurine hepatotoxicity in inflammatory bowel disease: the role for adding allopurinol.

  Expert opinion on drug safety 20080901

• Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides.

  Molecular cancer therapeutics 20080901

• [Benefits and risks of immunosuppression in chronic inflammatory bowel diseases].

  Deutsche medizinische Wochenschrift (1946) 20080901

• Azathioprine: when less is more.

  Journal of gastroenterology and hepatology 20080901

• The study of oxidization fluorescence sensor with molecular imprinting polymer and its application for 6-mercaptopurine (6-MP) determination.

  Talanta 20080815

• Clinical pharmacology and pharmacogenetics of thiopurines.

  European journal of clinical pharmacology 20080801

• Pure motor lumbosacral radiculopathy after intrathecal chemotherapy.

  European journal of neurology 20080801

• Palmar-plantar erythrodysesthesia caused by mercaptopurine and mesalamine.

  Archives of dermatology 20080801

• Immune reconstitution during maintenance therapy in children with acute lymphoblastic leukemia, relation to co-existing infection.

  Hematology (Amsterdam, Netherlands) 20080801

• Efficacy of 6-mercaptopurine treatment after azathioprine hypersensitivity in inflammatory bowel disease.

  World journal of gastroenterology 20080721

• Decrease in factor V activity: a new adverse effect of purine analogs in inflammatory bowel diseases?

  Inflammatory bowel diseases 20080701

• Effect of early immunomodulator use in moderate to severe pediatric Crohn disease.

  Inflammatory bowel diseases 20080701

• Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review.

  The American journal of gastroenterology 20080701

• Transporter-mediated protection against thiopurine-induced hematopoietic toxicity.

  Cancer research 20080701

• Effects and treatment of inflammatory bowel disease during pregnancy.

  Canadian family physician Medecin de famille canadien 20080701

• Severe neurotoxicities in a case of Charcot-Marie-Tooth disease type 2 caused by vincristine for acute lymphoblastic leukemia.

  Journal of pediatric hematology/oncology 20080701

• Down-regulation of Na+/H+ exchanger regulatory factor 1 increases expression and function of multidrug resistance protein 4.

  Cancer research 20080615

• Exposing the weaknesses: a systematic review of azathioprine efficacy in ulcerative colitis.

  Digestive diseases and sciences 20080601

• Increased dosing requirements for 6-mercaptopurine and azathioprine in inflammatory bowel disease patients six years and younger.

  Inflammatory bowel diseases 20080601

• Thiopurine methyltransferase activity combined with 6-thioguanine metabolite levels predicts clinical response to thiopurines in patients with inflammatory bowel disease.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20080601

• Withdrawal of immunosuppression in Crohn's disease treated with scheduled infliximab maintenance: a randomized trial.

  Gastroenterology 20080601

• Modulatory effects of 6-carboxymethylthiopurine on activated murine macrophages.

  Chemical biology & drug design 20080601

• Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20080601

• Effect of 6-mercaptopurine on rat placenta.

  The Journal of veterinary medical science 20080601

• Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine.

  Leukemia research 20080501

• 6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4.

  Human mutation 20080501

• Influence of MTHFR and RFC1 polymorphisms on toxicities during maintenance chemotherapy for childhood acute lymphoblastic leukemia or lymphoma.

  Journal of pediatric hematology/oncology 20080501

• [Immunomodulator therapy for maintenance of remission in Crohn's disease].

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20080501

• [The frequency and the course of the adverse effects of azathioprine/6-mercaptopurine treatment in patients with inflammatory bowel disease].

  The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20080501

• [The frequency and the course of the adverse effects of azathioprine/6-mercaptopurine treatment in patients with inflammatory bowel disease].

  The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20080501

• [Chemiluminescence determination of 6-mercaptopurine in the luminol-potassium ferricyanide system].

  Guang pu xue yu guang pu fen xi = Guang pu 20080501

• Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus.

  Biochemical pharmacology 20080415

• How are Azathioprine and 6-mercaptopurine dosed by gastroenterologists? Results of a survey of clinical practice.

  Inflammatory bowel diseases 20080401

• Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes.

  Toxicology in vitro : an international journal published in association with BIBRA 20080401

• In vivo immunomodulatory, cumulative skin irritation, sensitization and effect of d-limonene on permeation of 6-mercaptopurine through transdermal drug delivery.

  Biological & pharmaceutical bulletin 20080401

• Parotid acinar cell carcinoma in a long-term survivor of childhood acute lymphoblastic leukemia.

  Pediatric blood & cancer 20080301

• Thyroid involvement with Langerhans cell histiocytosis in a 3-year-old male.

  Pediatric blood & cancer 20080301

• EBV+ lymphoproliferative disease following prolonged chemotherapy for refractory LCH.

  Pediatric blood & cancer 20080301

• Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia.

  Pediatric blood & cancer 20080301

• Triple intrathecal therapy without cranial irradiation for central nervous system preventive therapy in childhood acute lymphoblastic leukemia.

  Pediatric blood & cancer 20080301

• Squamous dysplasia of the rectum in a patient with ulcerative colitis treated with 6-mercaptopurine.

  Digestive diseases and sciences 20080301

• Effect of buffer and antioxidant on stability of a mercaptopurine suspension.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080301

• The impact of medical therapy for inflammatory bowel disease on pregnancy outcome.

  The American journal of gastroenterology 20080301

• Tubulointerstitial nephritis: an extraintestinal manifestation of Crohn disease in children.

  Journal of pediatric gastroenterology and nutrition 20080301

• The Role of heat shock protein 27 in extravillous trophoblast differentiation.

  Journal of cellular biochemistry 20080215

• Treatment of neurodegenerative CNS disease in Langerhans cell histiocytosis with a combination of intravenous immunoglobulin and chemotherapy.

  Pediatric blood & cancer 20080201

• Tolerability and safety of mercaptopurine in azathioprine-intolerant patients with inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20080201

• Synthesis and cytotoxic activity of imidazo[1,2-a]-1,3,5-triazine analogues of 6-mercaptopurine.

  Archiv der Pharmazie 20080201

• Use of allopurinol with low-dose 6-mercaptopurine in inflammatory bowel disease to achieve optimal active metabolite levels: a review of four cases and the literature.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20080201

• Start low, go slow, but don't go this way yet.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20080201

• Gold nanoparticles enhance the anti-leukemia action of a 6-mercaptopurine chemotherapeutic agent.

  Langmuir : the ACS journal of surfaces and colloids 20080115

• Long-term results of the AIEOP-ALL-95 Trial for Childhood Acute Lymphoblastic Leukemia: insight on the prognostic value of DNA index in the framework of Berlin-Frankfurt-Muenster based chemotherapy.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080110

• IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations.

  British journal of clinical pharmacology 20080101

• Health care and cost of medication for inflammatory bowel disease in the Rhein-Main region, Germany: a multicenter, prospective, internet-based study.

  Inflammatory bowel diseases 20080101

• Disparities in the use of immunomodulators and biologics for the treatment of inflammatory bowel disease: a retrospective cohort study.

  Inflammatory bowel diseases 20080101

• Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer.

  Nature reviews. Cancer 20080101

• Stability of thiopurine metabolites: a potential analytical bias.

  Clinical chemistry 20080101

• Ondansetron-associated hypokalemia in a 2-year-old with pre-B-cell ALL.

  Journal of pediatric hematology/oncology 20080101

• Pharmacogenomics in gastrointestinal disorders.

  Methods in molecular biology (Clifton, N.J.) 20080101

• Histopathology of liver biopsies from a thiopurine-naïve inflammatory bowel disease cohort: prevalence of nodular regenerative hyperplasia.

  Scandinavian journal of gastroenterology 20080101

• The binding of the sulfur and oxygen purine derivatives with bovine serum albumin.

  Acta poloniae pharmaceutica 20080101

• Efficacy and safety of azathioprine and 6-mercaptopurine in Japanese pediatric patients with ulcerative colitis: a survey of the Japanese Society for Pediatric Inflammatory Bowel Disease.

  Digestion 20080101

• Membranous glomerulopathy associated with rheumatoid arthritis may respond to rituximab.

  Scandinavian journal of rheumatology 20080101

• [6-mercaptopurine-related hand-foot syndrome in a four-year-old child].

  Annales de dermatologie et de venereologie 20080101

• Treatment of acute lymphoblastic leukemia in children and adolescents: peaks and pitfalls.

  Hematology. American Society of Hematology. Education Program 20080101

• [Importance of genotyping of thiopurine S-methyltransferase in children with acute lymphoblastic leukaemia during maintenance therapy].

  Srpski arhiv za celokupno lekarstvo 20080101

• Effects of 5-fluorouracil on human mitogen-activated peripheral blood lymphocytes from healthy individuals.

  Anticancer research 20080101

• Sensitive mercury speciation by reversed-phase column high-performance liquid chromatography with UV-visible detection after solid-phase extraction using 6-mercaptopurine and dithizone.

  Journal of AOAC International 20080101

• Outcome after relapse among children with standard-risk acute lymphoblastic leukemia: Children's Oncology Group study CCG-1952.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20071220

• [Azathioprine and 6-mercaptopurine for maintenance treatment in ulcerative colitis. A survey of a Cochrane review].

  Ugeskrift for laeger 20071210

• Two cases of isolated symptomatic myocarditis induced by all-trans retinoic acid (ATRA).

  Annals of hematology 20071201

• A simple method for the preparation of PEG-6-mercaptopurine for oral administration.

  Bioorganic & medicinal chemistry letters 20071201

• Should TPMT genotype and activity be used to monitor 6-mercaptopurine treatment in children with acute lymphoblastic leukaemia?

  Journal of clinical pharmacy and therapeutics 20071201

• Methotrexate following unsuccessful thiopurine therapy in pediatric Crohn's disease.

  The American journal of gastroenterology 20071201

• The role of xanthine oxidase in thiopurine metabolism: a case report.

  Therapeutic drug monitoring 20071201

• Interaction between mercaptopurine and milk.

  Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20071201

• Optimizing drug therapy in inflammatory bowel disease.

  Current gastroenterology reports 20071201

• Hepatotoxicity of 6-mercaptopurine (6-MP) and Azathioprine (AZA) in adult IBD patients.

  The American journal of gastroenterology 20071101

• [Optimization of immunomodulatory treatment with azathioprine or 6-mercaptopurine in inflammatory bowel disease].

  Gastroenterologia y hepatologia 20071101

• Ulcerative colitis: diagnosis and treatment.

  American family physician 20071101

• [Current status of treatment of inflammatory bowel disease].

  Cirugia espanola 20071101

• [Pharmacogenomics of acute lymphoblastic leukemia].

  Medecine sciences : M/S 20071101

• [A short duration treatment with intensive consolidation therapy for patients with acute myelogenous leukemia--13 year experience in a single institute].

  Gan to kagaku ryoho. Cancer & chemotherapy 20071101

• [Prediction of adverse drug reactions based on genomic information].

  Nihon rinsho. Japanese journal of clinical medicine 20071028

• [Ulcerative colitis].

  Nihon rinsho. Japanese journal of clinical medicine 20071028

• Chemoprophylaxis of colorectal cancer in inflammatory bowel disease: current concepts.

  Inflammatory bowel diseases 20071001

• The low frequency of defective TPMT alleles in Turkish population: a study on pediatric patients with acute lymphoblastic leukemia.

  American journal of hematology 20071001

• Corticosteroid-dependent eosinophilic oesophagitis: azathioprine and 6-mercaptopurine can induce and maintain long-term remission.

  European journal of gastroenterology & hepatology 20071001

• [Common errors in the management of outpatients with inflammatory bowel disease].

  Gastroenterologia y hepatologia 20071001

• Mucormycosis presenting as recurrent gastric perforation in a patient with Crohn's disease on glucocorticoid, 6-mercaptopurine, and infliximab therapy.

  Digestive diseases and sciences 20070901

• Liver injury in inflammatory bowel disease: long-term follow-up study of 786 patients.

  Inflammatory bowel diseases 20070901

• Induction of acute lymphocytic leukemia differentiation by maintenance therapy.

  Leukemia 20070901

• Adverse reaction caused by excipients in mercaptopurine tablets.

  The Annals of pharmacotherapy 20070901

• Phase II study of chemotherapy and stem cell transplantation for adult acute lymphoblastic leukemia or lymphoblastic lymphoma: Japan Clinical Oncology Group Study 9004.

  Cancer science 20070901

• Effect of long-term low-dose prednisone on height velocity and disease activity in pediatric and adolescent patients with Crohn disease.

  Journal of pediatric gastroenterology and nutrition 20070901

• Relevance of pharmacogenetic aspects of mercaptopurine metabolism in the treatment of interstitial lung disease.

  Current opinion in pulmonary medicine 20070901

• Antimetabolite therapy for lesser-risk B-lineage acute lymphoblastic leukemia of childhood: a report from Children's Oncology Group Study P9201.

  Blood 20070815

• Importance of a hypervariable active-site residue in human Mu class glutathione transferases catalyzing the bioactivation of chemotherapeutic thiopurine prodrugs.

  Biochimica et biophysica acta 20070801

• The efficiency of a PAMAM dendrimer toward the encapsulation of the antileukemic drug 6-mercaptopurine.

  Anti-cancer drugs 20070801

• Should we test TPMT enzyme levels before starting azathioprine?

  Hematology (Amsterdam, Netherlands) 20070801

• A triangulation study of the clinician and patient experiences of the use of the immunosuppressant drugs azathioprine and 6-mercaptopurine for the management of inflammatory bowel disease.

  Journal of clinical nursing 20070801

• Severe pulmonary toxicity after azathioprine/6-mercaptopurine initiation for the treatment of inflammatory bowel disease.

  Journal of clinical gastroenterology 20070801

• In vitro study of 6-mercaptopurine oxidation catalysed by aldehyde oxidase and xanthine oxidase.

  Drug metabolism and pharmacokinetics 20070801

• The nucleoside and nucleotide mixture (OG-VI) rescues intestinal-like epithelial cells from the cytotoxicity of chemotherapeutic agents.

  The journal of medical investigation : JMI 20070801

• Solid-phase extraction and spectrophotometric determination of mercury with 6-mercaptopurine in environmental samples.

  Annali di chimica 20070801

• Adherence to thiopurine treatment in out-patients with Crohn's disease.

  Alimentary pharmacology & therapeutics 20070715

• Development of ulcerative colitis in a patient with multiple sclerosis following treatment with interferon beta 1a.

  World journal of gastroenterology 20070714

• Thiopurine-induced liver injury in patients with inflammatory bowel disease: a systematic review.

  The American journal of gastroenterology 20070701

• Therapeutic drug use in women with Crohn's disease and birth outcomes: a Danish nationwide cohort study.

  The American journal of gastroenterology 20070701

• 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial.

  Clinical chemistry 20070701

• Disseminated intravascular coagulation in acute leukemia at presentation and during induction therapy.

  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20070701

• Leupeptin inhibits ventilator-induced diaphragm dysfunction in rats.

  American journal of respiratory and critical care medicine 20070601

• Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs.

  Biochemical pharmacology 20070601

• Management of steroid-dependent ulcerative colitis: immunomodulatory agents, biologics, or surgery?

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070601

• Evaluation of renal function in Turkish children receiving BFM-95 therapy for acute lymphoblastic leukemia.

  Pediatric hematology and oncology 20070601

• 6-Mercaptopurine, an activator of Nur77, enhances transcriptional activity of HIF-1alpha resulting in new vessel formation.

  Oncogene 20070531

• Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics.

  Cancer research 20070515

• Reinduction of relapsed acute promyelocytic leukemia with ATRA and low dose antimetabolite-based chemotherapy.

  Pediatric blood & cancer 20070501

• Studies of interactions among cobalt(III) polypyridyl complexes, 6-mercaptopurine and DNA.

  Bioelectrochemistry (Amsterdam, Netherlands) 20070501

• Application of HPLC to study the kinetics of a branched bi-enzyme system consisting of hypoxanthine-guanine phosphoribosyltransferase and xanthine oxidase--an important biochemical system to evaluate the efficiency of the anticancer drug 6-mercaptopurine in ALL cell line.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501

• Thiopurine methyltransferase activity in Spain: a study of 14,545 patients.

  Digestive diseases and sciences 20070501

• Assessment of thiopurine methyltransferase enzyme activity is superior to genotype in predicting myelosuppression following azathioprine therapy in patients with inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20070501

• Thiopurine metabolite monitoring in paediatric inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20070415

• Relationship between 6-mercaptopurine dose and 6-thioguanine nucleotide levels in patients with inflammatory bowel disease.

  Inflammatory bowel diseases 20070401

• Azathioprine and breastfeeding: is it safe?

  BJOG : an international journal of obstetrics and gynaecology 20070401

• Comment: Breast-feeding during maternal use of azathioprine.

  The Annals of pharmacotherapy 20070401

• Impact of FLT3 internal tandem duplications on Indian acute promyelocytic leukemia patients: prognostic implications.

  Hematology (Amsterdam, Netherlands) 20070401

• Anticancer nucleobase analogues 6-mercaptopurine and 6-thioguanine are novel substrates for equilibrative nucleoside transporter 2.

  International journal of pharmaceutics 20070321

• T-cell acute lymphoblastic leukemia relapsing as acute myelogenous leukemia.

  Pediatric blood & cancer 20070301

• Autologous transplantation of CD133 selected hematopoietic progenitor cells for treatment of relapsed acute lymphoblastic leukemia.

  Pediatric blood & cancer 20070301

• Adolescents with acute lymphoblastic leukaemia: outcome on UK national paediatric (ALL97) and adult (UKALLXII/E2993) trials.

  Pediatric blood & cancer 20070301

• Improved outcome in childhood acute myeloid leukemia in Singapore with the MRC AML 10 protocol.

  Pediatric blood & cancer 20070301

• [Combination therapy with low-dose cyclosporin A, azathiopurine, and prednisolone for a child with refractory chronic idiopathic thrombocytopenic purpura].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 20070301

• 6-mercaptopurine (6-MP) entrapped stealth liposomes for improvement of leukemic treatment without hepatotoxicity and nephrotoxicity.

  Cancer investigation 20070301

• Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: results of an Austrian-German multicenter longitudinal study and implications for follow-up.

  Pediatric hematology and oncology 20070301

• Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines.

  Investigational new drugs 20070201

• Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20070201

• Efficient screening method of the thiopurine methyltransferase polymorphisms for patients considering taking thiopurine drugs in a Chinese Han population in Henan Province (central China).

  Clinica chimica acta; international journal of clinical chemistry 20070201

• Results of the PETHEMA ALL-96 trial in elderly patients with Philadelphia chromosome-negative acute lymphoblastic leukemia.

  European journal of haematology 20070201

• Nonadherence with thiopurine immunomodulator and mesalamine medications in children with Crohn disease.

  Journal of pediatric gastroenterology and nutrition 20070201

• A nudge in the right direction: shaping the metabolic fate of thiopurines for therapeutic gain.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070201

• Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070201

• Monitoring of thiopurine methyltransferase activity in postsurgical patients with Crohn's disease during 1 year of treatment with azathioprine or mesalazine.

  Therapeutic drug monitoring 20070201

• Analysis of ITPA phenotype-genotype correlation in the Bulgarian population revealed a novel gene variant in exon 6.

  Therapeutic drug monitoring 20070201

• Nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase--enzymatic reaction pathways of 6-mercaptopurine and 2-mercaptopurine are different.

  Biochemistry. Biokhimiia 20070201

• Activation of nuclear receptor Nur77 by 6-mercaptopurine protects against neointima formation.

  Circulation 20070130

• Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis.

  The Cochrane database of systematic reviews 20070124

• Pulses of vincristine and dexamethasone in addition to intensive chemotherapy for children with intermediate-risk acute lymphoblastic leukaemia: a multicentre randomised trial.

  Lancet (London, England) 20070113

• Targeting the cerebrovascular large neutral amino acid transporter (LAT1) isoform using a novel disulfide-based brain drug delivery system.

  Drug delivery 20070101

• Birth outcome in women treated with azathioprine or mercaptopurine during pregnancy: A Danish nationwide cohort study.

  Alimentary pharmacology & therapeutics 20070101

• [Case of severe ulcerative colitis successfully treated with intravenous cyclosporine without high dose corticosteroid].

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20070101

• Steroid treatment for severe acute cryptogenic hepatitis.

  Zeitschrift fur Gastroenterologie 20070101

• On the action of methotrexate and 6-mercaptopurine on M. avium subspecies paratuberculosis.

  PloS one 20070101

• Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing.

  Clinical pharmacokinetics 20070101

• Gastroparesis in patients with inactive Crohn's disease: a case series.

  BMC gastroenterology 20070101

• Adolescent adherence to oral therapy for leukemia: a focus group study.

  Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses 20070101

• Preferential inhibition of xanthine oxidase by 2-amino-6-hydroxy-8-mercaptopurine and 2-amino-6-purine thiol.

  BMC biochemistry 20070101

• Daunorubicin-induced cell kill with 1-hour versus 24-hour infusions: a randomized comparison in children with newly diagnosed acute lymphoblastic leukemia.

  Klinische Padiatrie 20070101

• The patient with persistent perianal fistulae.

  Best practice & research. Clinical gastroenterology 20070101

• [Modified BFM-90 regimen greatly improves treatment outcomes of chinese childhood and adolescent lymphoblastic lymphoma].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20070101

• [Comparison of the present and previously used protocol of risk stratification in children with acute lymphoblastic leukemia].

  Medycyna wieku rozwojowego 20070101

• Long-term graft function after allogeneic islet transplantation.

  Cell transplantation 20070101

• Thiopurine treatment in inflammatory bowel disease.

  Clinical pharmacokinetics 20070101

• [The results of a multicenter trial of acute lymphoblastic leukemia treatment on ALL-MB 91/ALL-BFM 90m in children: analysis of efficacy and toxicity].

  Terapevticheskii arkhiv 20070101

• [Combination of purine analogues and aminosalicylates in patients with inflammatory bowel disease: why and how?].

  Gastroenterologie clinique et biologique 20070101

• [Clinical manifestation of hepatotoxic effect of cytostatic chemicals].

  Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20070101

• Morphine in children with cancer: impact of age, chemotherapy and other factors on protein binding.

  Journal of pain & palliative care pharmacotherapy 20070101

• Acute lymphoblastic leukemia in a patient with chronic cyanoacrylate exposure.

  Acta haematologica 20070101

• Survival analysis.

  Methods in molecular biology (Clifton, N.J.) 20070101

• Body mass index does not influence pharmacokinetics or outcome of treatment in children with acute lymphoblastic leukemia.

  Blood 20061215

• Avascular necrosis--an antineoplastic-treatment-related toxicity: the experiences of two institutions.

  Pediatric hematology and oncology 20061201

• Adding pharmacogenetics information to drug labels: lessons learned.

  Pharmacogenetics and genomics 20061201

• Analysis of thiopurine S-methyltransferase polymorphism in the population of Serbia and Montenegro and mercaptopurine therapy tolerance in childhood acute lymphoblastic leukemia.

  Therapeutic drug monitoring 20061201

• Childhood CD4+/CD56+ hematodermic neoplasm: case report and review of the literature.

  Haematologica 20061201

• Favourable outcome in an APL patient with PLZF/RARalpha fusion gene: quantitative real-time RT-PCR confirms molecular response.

  Haematologica 20061201

• [Monitoring of thiopurine methyltransferase and thiopurine metabolites to optimize azathioprine therapy in inflammatory bowel disease].

  Gastroenterologia y hepatologia 20061101

• Thioguanine versus mercaptopurine in childhood ALL.

  Lancet (London, England) 20061014

• Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial.

  Lancet (London, England) 20061014

• Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease.

  Gut 20061001

• Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis.

  Journal of hepatology 20061001

• Decreased activity of clotting factor V during ALL consolidation treatment with mercaptopurine in a child.

  The Annals of pharmacotherapy 20061001

• Azathioprine as a postoperative prophylaxis reduces symptoms in aggressive Crohn's disease.

  Scandinavian journal of gastroenterology 20061001

• Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs.

  British journal of clinical pharmacology 20061001

• Leukocytapheresis in patients with moderate-severe steroid-dependant ulcerative colitis: clinical response without endoscopic response.

  Inflammatory bowel diseases 20061001

• The thiopurine methyltransferase genetic polymorphism is associated with thioguanine-related veno-occlusive disease of the liver in children with acute lymphoblastic leukemia.

  Clinical pharmacology and therapeutics 20061001

• [Postoperative recurrence in Crohn's disease. Risk factors and methods of prevention].

  La Tunisie medicale 20061001

• [The clinical features of B cell lymphoblastic lymphoma and outcomes after BFM-90 regimen therapy].

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20061001

• Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside.

  Biochemical pharmacology 20060928

• Oral outpatient chemotherapy medication errors in children with acute lymphoblastic leukemia.

  Cancer 20060915

• Symptomatic hypoglycemia: an unusual side effect of oral purine analogues for treatment of ALL.

  Pediatric blood & cancer 20060901

• Reduction in bioavailability of 6-mercaptopurine on simultaneous administration with cow's milk.

  Pediatric hematology and oncology 20060901

• Review article: thiopurines in inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20060901

• [A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient].

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20060901

• Next steps on the thiopurine methyltransferase 6-thioguanine nucleotide pathway.

  Journal of pediatric gastroenterology and nutrition 20060901

• Evolution of thiopurine use in pediatric inflammatory bowel disease in an academic center.

  Journal of pediatric gastroenterology and nutrition 20060901

• [Twenty years of treating childhood acute lymphoblastic leukemia].

  Anales de pediatria (Barcelona, Spain : 2003) 20060901

• Lack of cross-reactivity between 5-aminosalicylic acid-based drugs: a case report and review of the literature.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060901

• AIDS-associated Burkitt or Burkitt-like lymphoma: short intensive polychemotherapy is feasible and effective.

  Leukemia & lymphoma 20060901

• Incidence of neoplasms in patients who develop sustained leukopenia during or after treatment with 6-mercaptopurine for inflammatory bowel disease.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20060801

• TPMT, UGT1A1 and DPYD: genotyping to ensure safer cancer therapy?

  Trends in pharmacological sciences 20060801

• Case report: lymphoma arising in an ileal pouch anal anastomosis after immunomodulatory therapy for inflammatory bowel disease.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20060801

• Genetic variants and the risk of Crohn's disease: what does it mean for future disease management?

  Expert opinion on pharmacotherapy 20060801

• Physical activity during treatment in children with leukemia: a pilot study.

  Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 20060801

• Remission on thiopurinic immunomodulators normalizes quality of life and psychological status in patients with Crohn's disease.

  Inflammatory bowel diseases 20060801

• Systematic review of postoperative complications in patients with inflammatory bowel disease treated with immunomodulators.

  The British journal of surgery 20060701

• Pharmacogenetics in inflammatory bowel disease.

  World journal of gastroenterology 20060621

• Erythrocyte concentrations of metabolites or cumulative doses of 6-mercaptopurine and methotrexate do not predict liver changes in children treated for acute lymphoblastic leukemia.

  Pediatric blood & cancer 20060601

• Outcome of treatment in adults with Philadelphia chromosome-positive and/or BCR-ABL--positive acute lymphoblastic leukemia-retrospective analysis of Polish Adult Leukemia Group (PALG).

  Annals of hematology 20060601

• Primary endobronchial anaplastic large cell lymphoma in a pediatric patient.

  Puerto Rico health sciences journal 20060601

• Does intravenous 6-mercaptopurine decrease salvage after relapse in childhood acute lymphoblastic leukemia?

  Pediatric blood & cancer 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• The significance of minimal residual disease kinetics in adults with newly diagnosed PML-RARalpha-positive acute promyelocytic leukemia: results of a prospective trial.

  Haematologica 20060501

• [HPLC determination and diversity analysis of thiopurine methyltransferase activity in human and pig].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060501

• Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines.

  Biochemical and biophysical research communications 20060428

• Del(5q) and MLL amplification in homogeneously staining region in acute myeloblastic leukemia: a recurrent cytogenetic association.

  Annals of hematology 20060401

• 6-Thioguanine-related hepatotoxicity in patients with inflammatory bowel disease: dose or level dependent?

  Journal of hepatology 20060401

• Risk of lymphoma: inflammatory bowel disease and immunomodulators.

  Gut 20060401

• Role of treatment intensification in infants with acute lymphoblastic leukemia: results of two consecutive AIEOP studies.

  Haematologica 20060401

• Chemoprevention of colorectal neoplasia in ulcerative colitis: the effect of 6-mercaptopurine.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20060401

• When is too much enough?

  Gastroenterology 20060401

• Infliximab and azathioprine: bridge or parachute?

  Gastroenterology 20060401

• 5-aminosalicylate therapy is associated with higher 6-thioguanine levels in adults and children with inflammatory bowel disease in remission on 6-mercaptopurine or azathioprine.

  Inflammatory bowel diseases 20060401

• Inflammatory bowel disease in children: a pediatrician's perspective.

  Minerva pediatrica 20060401

• Infliximab for ulcerative colitis.

  The New England journal of medicine 20060330

• Orientation of 6-mercaptopurine SAMs at the silver electrode as studied by Raman mapping and in situ SERS.

  The journal of physical chemistry. B 20060323

• Case records of the Massachusetts General Hospital. Case 8-2006. A 71-year-old woman with Crohn's disease and altered mental status.

  The New England journal of medicine 20060316

• Chromosomal change during 6-mercaptopurine (6-MP) therapy in juvenile myelomonocytic leukemia: the growth of a 6-MP-refractory clone that already exists at onset.

  Leukemia 20060301

• Roles of protein C, protein S, and antithrombin III in acute leukemia.

  American journal of hematology 20060301

• American Gastroenterological Association Institute medical position statement on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease.

  Gastroenterology 20060301

• American Gastroenterological Association Institute technical review on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease.

  Gastroenterology 20060301

• How low is too low? Use of cluster analysis to define low levels of mercaptopurine metabolites.

  Pediatric blood & cancer 20060201

• Treatment adherence and 6-mercaptopurine metabolites.

  Pediatric blood & cancer 20060201

• Predictors of immunomodulator use as early therapy in pediatric Crohn's disease.

  Journal of clinical gastroenterology 20060201

• Treatment of severe disseminated juvenile systemic xanthogranuloma with multiple lesions in the central nervous system.

  Journal of pediatric hematology/oncology 20060201

• [Wegener's granulomatosis: Pathogenesis, pathophysiology, and therapy].

  Nihon rinsho. Japanese journal of clinical medicine 20060201

• Mechanistic mathematical modelling of mercaptopurine effects on cell cycle of human acute lymphoblastic leukaemia cells.

  British journal of cancer 20060116

• Thiopurine methyltransferase in acute lymphoblastic leukemia.

  Blood 20060115

• Is thiopurine therapy in ulcerative colitis as effective as in Crohn's disease?

  Gut 20060101

• Pharmacogenetics, adverse drug reactions and public health.

  Community genetics 20060101

• Choice of azathioprine or 6-mercaptopurine dose based on thiopurine methyltransferase (TPMT) activity to avoid myelosuppression. A prospective study.

  Hepato-gastroenterology 20060101

• The early history of chemical immunosuppression: 1900-1965.

  Journal of nephrology 20060101

• Overcoming the force and power of immunity: a history of immunosuppression in kidney transplantation.

  Journal of nephrology 20060101

• [Xenobiotic-metabolizing polymorphic enzymes. An opportunity for individualized drug treatment].

  Bulletin de l'Academie nationale de medecine 20060101

• Successful management of cerebral and pulmonary mucormycosis with liposomal amphotericin B in a 28-year-old woman with acute lymphoblastic leukemia.

  Acta bio-medica : Atenei Parmensis 20060101

• No induction of thiopurine methyltransferase during thiopurine treatment in inflammatory bowel disease.

  Nucleosides, nucleotides & nucleic acids 20060101

• Impaired transport as a mechanism of resistance to thiopurines in human T-lymphoblastic leukemia cells.

  Nucleosides, nucleotides & nucleic acids 20060101

• Determination of ITPase activity in erythrocyte lysates obtained for determination of TPMT activity.

  Nucleosides, nucleotides & nucleic acids 20060101

• Acute ascending motoric paraplegia following intrathecal chemotherapy for treatment of acute lymphoblastic leukemia in children: case reports and review of the literature.

  Klinische Padiatrie 20060101

• Thiopurine S-methyltransferase phenotype-genotype correlation in hemodialyzed patients.

  Pharmacological reports : PR 20060101

• [Reults of treatment with protocols BFM 90 and BFM 95].

  Medicinski arhiv 20060101

• [Auditory evoked potentials in patients after acute children's lymphoblastic leukemia treatment].

  Przeglad lekarski 20060101

• A randomized, postremission comparison of four courses of standard-dose consolidation therapy without maintenance therapy versus three courses of standard-dose consolidation with maintenance therapy in adults with acute myeloid leukemia: the Japan Adult Leukemia Study Group AML 97 Study.

  Cancer 20051215

• TPMT genotype and the use of thiopurines in paediatric inflammatory bowel disease.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20051201

• The thiopurines: an update.

  Investigational new drugs 20051201

• Observations on the use of allopurinol in combination with azathioprine or mercaptopurine.

  Alimentary pharmacology & therapeutics 20051201

• West Nile virus infection in a teenage boy with acute lymphocytic leukemia in remission.

  Journal of pediatric hematology/oncology 20051201

• Simultaneous control of third-degree graft-versus-host disease and prevention of recurrence of juvenile myelomonocytic leukemia (JMML) with 6-mercaptopurine following fulminant JMML relapse early after KIR-mismatched bone marrow transplantation.

  Journal of pediatric hematology/oncology 20051201

• p16 inactivation associated with aggressive clinical course and fatal outcome in TEL/AML1-positive acute lymphoblastic leukemia.

  Journal of pediatric hematology/oncology 20051201

• Role of 5'-nucleotidase in thiopurine metabolism: enzyme kinetic profile and association with thio-GMP levels in patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment.

  Clinica chimica acta; international journal of clinical chemistry 20051101

• Toxicity due to 6-thioquanine.

  Pediatric blood & cancer 20051101

• Liquid chromatography-tandem mass spectrometry analysis of erythrocyte thiopurine nucleotides and effect of thiopurine methyltransferase gene variants on these metabolites in patients receiving azathioprine/6-mercaptopurine therapy.

  Clinical chemistry 20051101

• Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics.

  Pharmacogenetics and genomics 20051101

• Incidence, risk factors and clinical course of thiopurine-induced liver injury in patients with inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20051101

• Lymphoma after Imuran and 6-MP: a new look.

  Journal of pediatric gastroenterology and nutrition 20051101

• Drug therapy for the treatment of Langerhans cell histiocytosis.

  Expert opinion on pharmacotherapy 20051101

• Membranous glomerulopathy in children given allogeneic hematopoietic stem cell transplantation.

  Haematologica 20051101

• Intracranial plasma cell granuloma: case report and treatment of recurrence with methotrexate and 6-mercaptopurine.

  Journal of pediatric hematology/oncology 20051101

• Alert: 6-mercaptopurine may be erroneously dispensed instead of propylthiouracil.

  Thyroid : official journal of the American Thyroid Association 20051101

• Treatment with all-trans retinoic acid and anthracycline monochemotherapy for children with acute promyelocytic leukemia: a multicenter study by the PETHEMA Group.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051020

• [Crohn's disease--standards of treatment 2004].

  Praxis 20051012

• The impact of age and gender on biology, clinical features and treatment outcome of non-Hodgkin lymphoma in childhood and adolescence.

  British journal of haematology 20051001

• Thiopurine therapies: problems, complexities, and progress with monitoring thioguanine nucleotides.

  Therapeutic drug monitoring 20051001

• The pharmacokinetic effect of discontinuation of mesalazine on mercaptopurine metabolite levels in inflammatory bowel disease patients.

  Alimentary pharmacology & therapeutics 20051001

• A cost-effectiveness analysis of alternative disease management strategies in patients with Crohn's disease treated with azathioprine or 6-mercaptopurine.

  The American journal of gastroenterology 20051001

• Thiopurine methyltransferase and 6-thioguanine nucleotide measurement: early experience of use in clinical practice.

  Internal medicine journal 20051001

• Chemoprevention of colorectal neoplasia in ulcerative colitis: the effect of 6-mercaptopurine.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20051001

• A prospective, open-label trial of 6-thioguanine in patients with ulcerative or indeterminate colitis.

  Scandinavian journal of gastroenterology 20051001

• On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprine or 6-mercaptopurine intolerant IBD patients.

  World journal of gastroenterology 20050921

• [Thiopurine methyltransferase activity in inflammatory bowel disease. A study on 7046 Spanish patients].

  Medicina clinica 20050910

• [Erythrocyte activity of thiopurine methyltransferase and treatment with thiopurines in inflammatory bowel disease].

  Medicina clinica 20050910

• Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment.

  Blood 20050901

• Fluorometric investigation of the interaction of bovine serum albumin with surfactants and 6-mercaptopurine.

  Journal of photochemistry and photobiology. B, Biology 20050901

• The yicM (nepI) gene of Escherichia coli encodes a major facilitator superfamily protein involved in efflux of purine ribonucleosides.

  FEMS microbiology letters 20050901

• Azathioprine pancreatitis in inflammatory bowel disease and successful subsequent treatment with mercaptopurine.

  Internal medicine journal 20050901

• Allopurinol safely and effectively optimizes tioguanine metabolites in inflammatory bowel disease patients not responding to azathioprine and mercaptopurine.

  Alimentary pharmacology & therapeutics 20050901

• Nuclear winter.

  Transfusion 20050901

• Adsorption of 6-mercaptopurine and 6-mercaptopurine-ribosideon silver colloid: a pH-dependent surface-enhanced Raman spectroscopy and density functional theory study. II. 6-mercaptopurine-riboside.

  Biopolymers 20050815

• [Epstein-Barr virus-related lymphomas in patients with inflammatory bowel disease].

  Nederlands tijdschrift voor geneeskunde 20050813

• Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine.

  Gut 20050801

• Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.

  Journal of gastroenterology and hepatology 20050801

• Liposomal formulations of inflammatory bowel disease drugs: local versus systemic drug delivery in a rat model.

  Pharmaceutical research 20050801

• Development of hepatocellular carcinoma following treatment with 6-mercaptopurine for ulcerative colitis: investigation of chromosomal aberration by comparative genomic hybridization.

  International journal of clinical oncology 20050801

• Interventions for growth failure in childhood Crohn's disease.

  The Cochrane database of systematic reviews 20050720

• Interference free and simplyfied liquid chromatography-based determination of thiopurine S-methyltransferase activity in erythrocytes.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050705

• Intravenous 6-mercaptopurine decreases salvage after relapse in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group study CCG 1922.

  Pediatric blood & cancer 20050701

• Do minor differences in primary therapy influence rescue-ability after relapse in childhood ALL?

  Pediatric blood & cancer 20050701

• In vitro activity of imatinib in cells from patients with adult acute lymphoblastic leukemia.

  Anti-cancer drugs 20050701

• Thiopurine S-methyltransferase as a target for drug interactions.

  European journal of clinical pharmacology 20050701

• Rosai-Dorfman disease: successful long-term results by combination chemotherapy with prednisone, 6-mercaptopurine, methotrexate, and vinblastine: a case report.

  International journal of surgical pathology 20050701

• Modeling of purine derivatives transport across cell membranes based on their partition coefficient determination and quantum chemical calculations.

  Journal of medicinal chemistry 20050630

• Pediatric inflammatory bowel disease: what children can teach adults.

  Inflammatory bowel diseases 20050601

• Determination of mercaptopurine and its four metabolites by large-volume sample stacking with polarity switching in capillary electrophoresis.

  Electrophoresis 20050601

• Azathioprine, 6-mercaptopurine and thiopurine S-methyltransferase.

  Journal of gastroenterology and hepatology 20050601

• TRAP220 is modulated by the antineoplastic agent 6-Mercaptopurine, and mediates the activation of the NR4A subgroup of nuclear receptors.

  Journal of molecular endocrinology 20050601

• Pyoderma gangrenosum associated with osteomyelitis in a paediatric patient: a case report.

  The West Indian medical journal 20050601

• [Pharmacogenetics of inflammatory bowel disease].

  Orvosi hetilap 20050522

• [Individual monitoring of thiopurine and methotrexate treatment].

  Ugeskrift for laeger 20050516

• [Immunosuppressive agents: Imurel and Purinethol].

  La Revue du praticien 20050515

• Value of intravenous 6-mercaptopurine during continuation treatment in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma: final results of a randomized phase III trial (58881) of the EORTC CLG.

  Leukemia 20050501

• The effect of 6-mercaptopurine on early human placental explants.

  Human reproduction (Oxford, England) 20050501

• Immunosuppressive efficacy of mycophenolate mofetil when compared with azathioprine and mizoribine against peripheral lymphocytes from renal transplant recipients.

  Transplant international : official journal of the European Society for Organ Transplantation 20050501

• [Immunosuppressants for therapy of patients with ulcerative colitis].

  Nihon rinsho. Japanese journal of clinical medicine 20050501

• [Guidelines for treatment of ulcerative colitis in children].

  Nihon rinsho. Japanese journal of clinical medicine 20050501

• Amphotericin B-induced nephrogenic diabetes insipidus in a case of cryptococcemia.

  Internal medicine (Tokyo, Japan) 20050501

• [Azathioprine].

  Nihon rinsho. Japanese journal of clinical medicine 20050501

• ITPA genotyping test does not improve detection of Crohn's disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression.

  Gut 20050401

• Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20050401

• 6-tioguanine monitoring in steroid-dependent patients with inflammatory bowel diseases receiving azathioprine.

  Alimentary pharmacology & therapeutics 20050401

• Sudden onset of Multiple nevi after administration of 6-mercaptopurine in an adult with Crohn's disease: a case report.

  International journal of dermatology 20050401

• Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.

  Cancer cell 20050401

• Effects of 6-mercaptopurine treatment on sperm production and reproductive performance: a study in male mice.

  Scandinavian journal of gastroenterology 20050401

• A simple hybrid variance estimator for the Kaplan-Meier survival function.

  Statistics in medicine 20050330

• Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia.

  JAMA 20050323

• Portal hypertension develops in a subset of children with standard risk acute lymphoblastic leukemia treated with oral 6-thioguanine during maintenance therapy.

  Pediatric blood & cancer 20050301

• Can we alter the natural history of Crohn disease in children?

  Journal of pediatric gastroenterology and nutrition 20050301

• Measurement of thiopurine methyl transferase activity guides dose-initiation and prevents toxicity from azathioprine.

  The New Zealand medical journal 20050225

• Raman mapping and in situ SERS spectroelectrochemical studies of 6-mercaptopurine SAMs on the gold electrode.

  The journal of physical chemistry. B 20050224

• Explained randomness in proportional hazards models.

  Statistics in medicine 20050215

• Review article: monitoring of immunomodulators in inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20050215

• [Inflammatory bowel disease--diagnosis and therapy].

  Praxis 20050202

• Selective inhibition of inflammatory gene expression in activated T lymphocytes: a mechanism of immune suppression by thiopurines.

  The Journal of pharmacology and experimental therapeutics 20050201

• Use of 6-mercaptopurine/azathioprine as the immunomodulator of choice for moderately active Crohn's disease: pro.

  Inflammatory bowel diseases 20050201

• Use of 6-mercapturine/azathioprine as the immunomodulator of choice for moderately active Crohn's disease: con.

  Inflammatory bowel diseases 20050201

• Use of 6-mercaptopurine/azathioprine as the immunomodulator of choice for moderately active Crohn's disease: balance.

  Inflammatory bowel diseases 20050201

• Hepatosplenic T-cell lymphoma in an adolescent patient after immunomodulator and biologic therapy for Crohn disease.

  Journal of pediatric gastroenterology and nutrition 20050201

• Advanced-stage large-cell lymphoma in children and adolescents: results of a randomized trial incorporating intermediate-dose methotrexate and high-dose cytarabine in the maintenance phase of the APO regimen: a Pediatric Oncology Group phase III trial.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050120

• [Treatment results with ALL-BFM-95 protocol in children with acute lymphoblastic leukemia in Hungary].

  Orvosi hetilap 20050109

• The ten-year single-center experience with 6-mercaptopurine in the treatment of inflammatory bowel disease.

  Journal of clinical gastroenterology 20050101

• Azathioprine and 6 Mercaptopurine in postoperative maintenance of Crohn's disease remission: is no evidence of effect an evidence of no effect?

  Gastroenterology 20050101

• 6-Mercaptopurine and mesalamine for prevention of relapse after conservative surgery for Crohn's disease.

  Gastroenterology 20050101

• Treatment of acute lymphocytic leukemia using zinc adjuvant with chemotherapy and radiation--a case history and hypothesis.

  Medical hypotheses 20050101

• 6-mercaptopurine in patients with inflammatory bowel disease and previous digestive intolerance of azathioprine.

  Scandinavian journal of gastroenterology 20050101

• [Evaluation of compliance through specific interviews: a prospective study of 73 children with acute lymphoblastic leukemia].

  Jornal de pediatria 20050101

• [Treatment of adult Berkitt-like lymphoma].

  Terapevticheskii arkhiv 20050101

• Effects of 6-mercaptopurine (6-MP) on histomorphometric parameters of the rat bones.

  Pharmacological reports : PR 20050101

• Treatment of acute promyelocytic leukemia: a single institution experience.

  Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion 20050101

• Designing drugs.

  American heritage of invention & technology 20050101

• Prognostic impact of age in children and adolescents with acute lymphoblastic leukemia: data from the trials ALL-BFM 86, 90, and 95.

  Klinische Padiatrie 20050101

• [Treatment results of Langerhans cell histiocytosis with LSH II protocol].

  Casopis lekaru ceskych 20050101

• Electrochemical determination of 6-mercaptopurine at silver microdisk electrodes.

  Annali di chimica 20050101

• 6-mercaptopurine and daunorubicin double drug liposomes-preparation, drug-drug interaction and characterization.

  Journal of liposome research 20050101

• Medical therapy for ulcerative colitis: the state of the art and beyond.

  Current gastroenterology reports 20041201

• Advances in medical therapy for Crohn's disease.

  Current gastroenterology reports 20041201

• Childhood leukaemia: a relationship between intracellular 6-mercaptopurine metabolites and neutropenia. 1983.

  British journal of clinical pharmacology 20041201

• [Efficacy of modified BFM-90 regimen on children and adolescents with T cell lymphoblastic lymphoma: a report of 20 cases].

  Ai zheng = Aizheng = Chinese journal of cancer 20041201

• Acute promyelocytic leukemia and HIV-1 infection: case report and review of the literature.

  American journal of hematology 20041101

• Use of laboratory testing to guide 6-mercaptopurine/azathioprine therapy.

  Gastroenterology 20041101

• Monitoring of long-term thiopurine therapy among adults with inflammatory bowel disease.

  Scandinavian journal of gastroenterology 20041101

• [Primary study of relationship between serum level of VEGF and non-Hodgkin's lymphoma in children and adolescent patients].

  Ai zheng = Aizheng = Chinese journal of cancer 20041101

• Efficacy of conventional immunosuppressive drugs in IBD.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20041101

• Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis.

  European journal of gastroenterology & hepatology 20041101

• [Chronic inflammatory bowel diseases].

  Deutsche medizinische Wochenschrift (1946) 20041015

• Ulcerative colitis: conservative management and long-term effects.

  Langenbeck's archives of surgery 20041001

• Review article: chronic active disease and maintaining remission in Crohn's disease.

  Alimentary pharmacology & therapeutics 20041001

• Sperm, sex, and 6-MP: the perception on conception.

  Gastroenterology 20041001

• The clinical impact of thiopurine methyltransferase polymorphisms on thiopurine treatment.

  Nucleosides, nucleotides & nucleic acids 20041001

• Allele frequency of inosine triphosphate pyrophosphatase gene polymorphisms in a Japanese population.

  Nucleosides, nucleotides & nucleic acids 20041001

• Azathioprine formulation optimizes metabolite profile in inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20040915

• Inflammatory bowel disease: management issues during pregnancy.

  Archives of gynecology and obstetrics 20040901

• Diagnosis of 6 mercaptopurine hepatotoxicity post liver transplantation utilizing metabolite assays.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040901

• Improved HPLC methodology for monitoring thiopurine metabolites in patients on thiopurine therapy.

  Clinical biochemistry 20040901

• The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease.

  The American journal of gastroenterology 20040901

• Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20040901

• Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo: a 2-year trial.

  Gastroenterology 20040901

• The efficacy of azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in patients with Crohn's disease remains uncertain.

  Gastroenterology 20040901

• [Ulcerative colitis. Chronic active course].

  Zeitschrift fur Gastroenterologie 20040901

• [Ulcerative colitis. Maintenance therapy].

  Zeitschrift fur Gastroenterologie 20040901

• [Immunosuppressive therapy for inflammatory bowel disease: consensus by the Austrian working group on IBD].

  Zeitschrift fur Gastroenterologie 20040901

• Could immunosuppressive drugs reduce recurrence rate after second resection for Crohn disease?

  Inflammatory bowel diseases 20040901

• Drug therapy for ulcerative colitis.

  World journal of gastroenterology 20040815

• The fidelity of replication of the three-base-pair set adenine/thymine, hypoxanthine/cytosine and 6-thiopurine/5-methyl-2-pyrimidinone with T7 DNA polymerase.

  The Biochemical journal 20040801

• A comparison of red blood cell thiopurine metabolites in children with acute lymphoblastic leukemia who received oral mercaptopurine twice daily or once daily: a Pediatric Oncology Group study (now The Children's Oncology Group).

  Pediatric blood & cancer 20040801

• Clinical significance of azathioprine active metabolite concentrations in inflammatory bowel disease.

  Gut 20040801

• Clinical and laboratory evaluation of compliance in acute lymphoblastic leukaemia.

  Archives of disease in childhood 20040801

• Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs.

  Journal of neurochemistry 20040801

• [A systematic review of the clinical effectiveness of azathioprine in patients with ulcerative colitis].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040801

• Thiopurine drug adverse effects in a population of New Zealand patients with inflammatory bowel disease.

  Pharmacoepidemiology and drug safety 20040801

• How effective are the usual treatments for Crohn's disease?

  Alimentary pharmacology & therapeutics 20040715

• Efficacy and safety of thiopurinic immunomodulators (azathioprine and mercaptopurine) in steroid-dependent ulcerative colitis.

  Alimentary pharmacology & therapeutics 20040715

• Some cases demonstrating the clinical usefulness of therapeutic drug monitoring in thiopurine-treated inflammatory bowel disease patients.

  European journal of gastroenterology & hepatology 20040701

• Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?

  Annals of clinical biochemistry 20040701

• Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease.

  Inflammatory bowel diseases 20040701

• [A study on inclusion complexes of cyclodextrin with three anticancer xanthines by fluorescence].

  Guang pu xue yu guang pu fen xi = Guang pu 20040701

• Using pharmacogenetics to improve drug safety and efficacy.

  JAMA 20040616

• Pharmacokinetics of 6-mercaptopurine in patients with inflammatory bowel disease: implications for therapy.

  Therapeutic drug monitoring 20040601

• Frequency distribution of thiopurine S-methyltransferase activity in red blood cells of a healthy Japanese population.

  Therapeutic drug monitoring 20040601

• General principles of medical therapy of inflammatory bowel disease.

  Gastroenterology clinics of North America 20040601

• Treatment of inflammatory bowel disease with azathioprine and 6-mercaptopurine.

  Gastroenterology clinics of North America 20040601

• Medical management of severe ulcerative colitis.

  Gastroenterology clinics of North America 20040601

• Medical management of postoperative recurrence in Crohn's disease.

  Gastroenterology clinics of North America 20040601

• Medical management of the pregnant patient with inflammatory bowel disease.

  Gastroenterology clinics of North America 20040601

• Discordant erythrocyte sedimentation rate and C-reactive protein in children with inflammatory bowel disease taking azathioprine or 6-mercaptopurine.

  Journal of pediatric gastroenterology and nutrition 20040501

• An improved HPLC method for the quantitation of 6-mercaptopurine and its metabolites in red blood cells.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20040501

• Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20040501

• Toxic ingestion of 6-mercaptopurine by young siblings of pediatric oncology patients.

  The Journal of pediatrics 20040501

• Additional discussion on the safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study.

  Gastroenterology 20040501

• Pharmacogenetic determinants of outcome in acute lymphoblastic leukaemia.

  British journal of haematology 20040501

• Methylated metabolites of 6-mercaptopurine are associated with hepatotoxicity.

  Clinical pharmacology and therapeutics 20040401

• Bone marrow necrosis in a patient with acute promyelocytic leukemia during re-induction therapy with arsenic trioxide.

  European journal of haematology 20040401

• Analytic aspects of monitoring therapy with thiopurine medications.

  Therapeutic drug monitoring 20040401

• The analysis of correlations between drug resistance and clinical/laboratory measures found in a group of children with all treated by ALL-BFM 90 protocol.

  Bulletin du cancer 20040401

• The risk of congenital abnormalities in children fathered by men treated with azathioprine or mercaptopurine before conception.

  Alimentary pharmacology & therapeutics 20040315

• A multiplexed allele-specific polymerase chain reaction assay for the detection of common thiopurine S-methyltransferase (TPMT) mutations.

  Clinica chimica acta; international journal of clinical chemistry 20040301

• Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National Cancer Institute's anticancer drug screen.

  Drug metabolism and disposition: the biological fate of chemicals 20040301

• Thiopurine S-methyltransferase polymorphisms: efficient screening method for patients considering taking thiopurine drugs.

  European journal of clinical pharmacology 20040301

• A search for the optimal duration of treatment with 6-mercaptopurine for ulcerative colitis.

  The American journal of gastroenterology 20040301

• Toxicity of low dose azathioprine and 6-mercaptopurine in rat hepatocytes. Roles of xanthine oxidase and mitochondrial injury.

  Journal of hepatology 20040301

• 6-Mercaptopurine is effective in Crohn's disease without concomitant steroids.

  Inflammatory bowel diseases 20040301

• Pulmonary involvement in Crohn's disease report of a case and review of the literature.

  Inflammatory bowel diseases 20040301

• Pharmacogenetics and inflammatory bowel disease: progress and prospects.

  Inflammatory bowel diseases 20040301

• Effect of antimetabolite immunosuppressants on Flaviviridae, including hepatitis C virus.

  Transplantation 20040227

• Antagonist: Early surgical intervention in ulcerative colitis.

  Gut 20040201

• Healthy offspring in parents both receiving thiopurines.

  Gastroenterology 20040201

• [Observation on treatment of post-remission acute myeloid leukemia patients by lingxiong piaoling powder and longchan cigu decoction].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040201

• Azathioprine transport through rat skin and its immunosuppressive effect.

  Die Pharmazie 20040201

• Prolonged remission of severe Crohn's disease after fever and leukopenia caused by 6-mercaptopurine.

  Digestive diseases and sciences 20040201

• Pharmacogenomics and IBD: TPMT and thiopurines.

  Inflammatory bowel diseases 20040201

• Bone marrow stroma damage induced by chemotherapy for acute lymphoblastic leukemia in children.

  Pediatric research 20040101

• Relevance of thiopurine methyltransferase status in rheumatology patients receiving azathioprine.

  Rheumatology (Oxford, England) 20040101

• Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders. The impact of TPMT genotyping in predicting toxicity.

  European journal of clinical pharmacology 20040101

• Two-day induction with thymoglobulin in kidney transplantation: risks and benefits.

  Transplantation proceedings 20040101

• Maintenance therapy in childhood acute myeloid leukemia.

  Annals of hematology 20040101

• All-transretinoic acid and chemotherapy in the treatment of acute promyelocytic leukemia.

  Indian journal of cancer 20040101

• PEG prodrugs of 6-mercaptopurine for parenteral administration using benzyl elimination of thiols.

  Oncology research 20040101

• [Immunosupressants and MICI].

  Gastroenterologie clinique et biologique 20040101

• [Treatment results in children with standard-risk acute lymphoblastic leukemia. Report of the Polish Pediatric Leukemia/Lymphoma Study Group].

  Przeglad lekarski 20040101

• Reduction of drug toxicity using dendrimers based on melamine.

  Molecular pharmaceutics 20040101

• Optimizing immunomodulator therapy for inflammatory bowel disease.

  Current gastroenterology reports 20031201

• Role of macrophages and stellate cells in the pathogenesis of veno-occlusive disease: an electron microscopic case study.

  Experimental and molecular pathology 20031201

• [Relationship between single nucleotide polymorphisms in thiopurine methyltransferase gene and tolerance to thiopurines in acute leukemia].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20031201

• Fistula response to methotrexate in Crohn's disease: a case series.

  Alimentary pharmacology & therapeutics 20031115

• Spectroscopy behavior of 6-Mercaptopurine, Azathiopurine, and 8-Azaguanine.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20031101

• Predictive factors of response of perianal Crohn's disease to azathioprine or 6-mercaptopurine.

  Diseases of the colon and rectum 20031101

• Protein expression of the glucocorticoid receptor in childhood acute lymphoblastic leukemia.

  Haematologica 20031101

• Discussion on the safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study.

  Gastroenterology 20031101

• Monitoring of AZA/6-MP treatment in children with IBD is necessary.

  Inflammatory bowel diseases 20031101

• Monitoring of azathioprine/6-mercaptopurine treatment in children with IBD is not necessary.

  Inflammatory bowel diseases 20031101

• 6TG: when less is more than you bargained for.

  Inflammatory bowel diseases 20031101

• High-performance liquid chromatographic assay of metabolites of thioguanine and mercaptopurine in capillary blood.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031025

• Preventing toxicity with a gene test.

  Science (New York, N.Y.) 20031024

• Thioguanine offers no advantage over mercaptopurine in maintenance treatment of childhood ALL: results of the randomized trial COALL-92.

  Blood 20031015

• Veno-occlusive disease in patients receiving thiopurines during maintenance therapy for childhood acute lymphoblastic leukaemia.

  British journal of haematology 20031001

• [Juvenile myelomonocytic leukaemia, xanthoma, and neurofibromatosis type 1].

  Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20031001

• Cumulative experience with short- and long-term toxicity to 6-mercaptopurine in the treatment of Crohn's disease and ulcerative colitis.

  Journal of clinical gastroenterology 20030901

• Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20030815

• Tioguanine in patients with Crohn's disease intolerant or resistant to azathioprine/mercaptopurine.

  Alimentary pharmacology & therapeutics 20030815

• Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia.

  International journal of oncology 20030801

• Msh2 deficiency attenuates but does not abolish thiopurine hematopoietic toxicity in msh2-/- mice.

  Molecular pharmacology 20030801

• Corticosteroids and immunomodulators: postoperative infectious complication risk in inflammatory bowel disease patients.

  Gastroenterology 20030801

• 6-mercaptopurine beats a bum rap.

  Gastroenterology 20030801

• Study of the interaction of 6-mercaptopurine with protein by microdialysis coupled with LC and electrochemical detection based on functionalized multi-wall carbon nanotubes modified electrode.

  Journal of pharmaceutical and biomedical analysis 20030714

• The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine.

  The Journal of biological chemistry 20030704

• Identification of the antineoplastic agent 6-mercaptopurine as an activator of the orphan nuclear hormone receptor Nurr1.

  The Journal of biological chemistry 20030704

• Real-time RT-PCR methodology for quantification of thiopurine methyltransferase gene expression.

  European journal of clinical pharmacology 20030701

• Severe gastrointestinal illness associated with olestra ingestion.

  Journal of pediatric gastroenterology and nutrition 20030701

• Dose reduction of coadministered 6-mercaptopurine decreases myelotoxicity following high-dose methotrexate in childhood leukemia.

  Leukemia 20030701

• A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL.

  Leukemia 20030701

• Erythrocyte mean corpuscular volume as a surrogate marker for 6-thioguanine nucleotide concentration monitoring in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine.

  Inflammatory bowel diseases 20030701

• [Thiopurine methyltransferase activity and myelosuppression in inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine].

  Medicina clinica 20030607

• Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia.

  Clinical pharmacology and therapeutics 20030601

• Long-term survival in acute lymphoblastic leukaemia in adults treated according to the LALA 87 protocol.

  Chemotherapy 20030601

• Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group.

  Blood 20030515

• Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells.

  Nature genetics 20030501

• 6-mercaptopurine and inflammatory bowel disease: hidden ground for the cytomegalovirus.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20030501

• Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine.

  The American journal of gastroenterology 20030501

• [Auto-immune hepatitis: therapeutic management].

  Gastroenterologie clinique et biologique 20030501

• Complications of pregnancy and child development after cessation of treatment with 6-mercaptopurine for inflammatory bowel disease.

  Journal of clinical gastroenterology 20030401

• Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030401

• Topical delivery of 5-fluorouracil and 6-mercaptopurine by their alkylcarbonyloxymethyl prodrugs from water: vehicle effects on design of prodrugs.

  Pharmaceutical research 20030401

• Cancer pharmacogenomics: current and future applications.

  Biochimica et biophysica acta 20030317

• Azathioprine, mercaptopurine and birth outcome: a population-based cohort study.

  Alimentary pharmacology & therapeutics 20030315

• High survival rate in childhood non-Hodgkin lymphoma without CNS involvement: results of BFM 95 study in Kuwait.

  Pediatric hematology and oncology 20030301

• Benign intracranial hypertension in association with acute lymphoblastic leukemia.

  Pediatric hematology and oncology 20030301

• Hepatotoxicity associated with 6-thioguanine therapy for Crohn's disease.

  Journal of clinical gastroenterology 20030301

• Thiopurine therapy: when to start and when to stop.

  European journal of gastroenterology & hepatology 20030301

• Successful reintroduction of methotrexate after acute pneumonitis in a patient with acute lymphoblastic leukemia.

  Annals of hematology 20030301

• Treatment of recurrent eosinophilic granuloma with systemic therapy.

  Ophthalmic plastic and reconstructive surgery 20030301

• First experience with intracytoplasmic sperm injection for extreme oligozoospermia associated with Crohn's disease and 6-mercaptopurine chemotherapy.

  Asian journal of andrology 20030301

• Immunomodulators and 'on demand' therapy with infliximab in Crohn's disease: clinical experience with 400 infusions.

  The American journal of gastroenterology 20030301

• [Management of ulcerative colitis].

  Therapeutische Umschau. Revue therapeutique 20030301

• Comparison of suppressive potency between azathioprine and 6-mercaptopurine against mitogen-induced blastogenesis of human peripheral blood mononuclear cells in-vitro.

  The Journal of pharmacy and pharmacology 20030301

• Position statement: immunomodulator therapy for inflammatory Bowel disease.

  The Israel Medical Association journal : IMAJ 20030301

• [Therapy of chronic inflammatory bowel diseases with azathioprine, 6-mercaptopurine and 6-thioguanine. Clinico-pharmacologic aspects].

  Deutsche medizinische Wochenschrift (1946) 20030221

• 6-thioguanine--efficacy and safety in chronic active Crohn's disease.

  Alimentary pharmacology & therapeutics 20030215

• Cyclosporin for refractory ulcerative colitis.

  Gut 20030201

• Diminished anticoagulant effects of warfarin with concomitant mercaptopurine therapy.

  Pharmacotherapy 20030201

• Optimizing treatment with thioguanine derivatives in inflammatory bowel disease.

  Best practice & research. Clinical gastroenterology 20030201

• Dental abnormalities in children after chemotherapy treatment for acute lymphoid leukemia.

  Leukemia research 20030101

• Mercaptopurine metabolite results in clinical gastroenterology practice.

  Alimentary pharmacology & therapeutics 20030101

• The safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study.

  Gastroenterology 20030101

• Application of pharmacokinetic/pharmacodynamic and stochastic modelling to 6-mercaptopurine micronucleus induction in mouse bone marrow erythrocytes.

  Journal of applied toxicology : JAT 20030101

• [Invasive cancer of the cervix in a patient undergoing chronic treatment with 6-mercaptopurine for Crohns disease].

  Gastroenterologia y hepatologia 20030101

• Azathioprine and anti-TNF alpha therapies in Crohn's disease: a review of pharmacology, clinical efficacy and safety.

  Pharmacological research 20030101

• [Acute episode].

  Zeitschrift fur Gastroenterologie 20030101

• [Chronically active Crohn's disease].

  Zeitschrift fur Gastroenterologie 20030101

• [Maintaining a remission].

  Zeitschrift fur Gastroenterologie 20030101

• Combination therapy in childhood leukaemia: in vitro studies of thiopurines and inhibitors of purine metabolism on apoptosis.

  Annals of clinical biochemistry 20030101

• Measurement of thiopurine S-methyltransferase activity in human blood samples based on high-performance liquid chromatography: reference values in erythrocytes from children.

  Annals of clinical biochemistry 20030101

• 6-Thioguanine seems promising in azathioprine- or 6-mercaptopurine-intolerant inflammatory bowel disease patients: a short-term safety assessment.

  European journal of gastroenterology & hepatology 20030101

• [Significance of TPMT activity and TGNs level detection for individualizing 6-mercaptopurine chemotherapy].

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20030101

• Therapeutic efficacy and safety of 6-mercaptopurine and azathioprine in patients with Crohn's disease.

  Reviews in gastroenterological disorders 20030101

• Clinical use and practical application of TPMT enzyme and 6-mercaptopurine metabolite monitoring in IBD.

  Reviews in gastroenterological disorders 20030101

• Optimizing the therapeutic potential of azathioprine/6-mercaptopurine in the treatment of inflammatory bowel disease.

  Journal of clinical gastroenterology 20030101

• Utility of measuring 6-methylmercaptopurine and 6-thioguanine nucleotide levels in managing inflammatory bowel disease patients treated with 6-mercaptopurine in a clinical practice setting.

  Journal of clinical gastroenterology 20030101

• Optimization and individualization of thiopurine therapy in inflammatory bowel disease: the great variability among drug responses.

  The pharmacogenomics journal 20030101

• A national survey on the patterns of treatment of inflammatory bowel disease in Canada.

  BMC gastroenterology 20030101

• [The assessment of plasma levels of insulin-like growth factor (IGF-I) and binding protein (IGFBP-3) during the maintenance therapy and after remissionof acute lymphoblastic leukemia (ALL)].

  Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych 20030101

• [The influence of age, gender and modifications of therapeutic protocols on physical development of children and adolescents after completion of therapy for acute lymphoblastic leukemia].

  Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych 20030101

• A case of leukemia of the appendix presenting as acute appendicitis.

  Acta haematologica 20030101

• Pharmacogenomics of azathioprine and 6-mercaptopurine in gastroenterologic therapy.

  Reviews in gastroenterological disorders 20030101

• Role and side-effects of TPMT polymorphisms of 6-MP and azathioprine in the treatment of steroid-resistant and -dependent ulcerative colitis.

  Journal of gastroenterology 20030101

• [Improved results in children with acute lymphoblastic leukemia treated with the ALL-BFM 90 protocol in the Czech Republic].

  Casopis lekaru ceskych 20030101

• Thioguanine, mercaptopurine: their analogs and nucleosides as antimetabolites.

  Current pharmaceutical design 20030101

• Cancer pharmacogenomics: SNPs, chips, and the individual patient.

  Cancer investigation 20030101

• Comparative kinetics of azathioprine and metazathioprine mercaptolysis in presence of physiological thiols.

  Acta poloniae pharmaceutica 20030101

• Safety of thiopurines in the treatment of inflammatory bowel disease.

  Scandinavian journal of gastroenterology. Supplement 20030101

• [Efficacy of medical therapy in preventing the post-surgical recurrence in Crohn's disease].

  Annali italiani di chirurgia 20030101

• [Conservative therapy of inflammatory bowel diseases].

  Orvosi hetilap 20021215

• Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells.

  Molecular pharmacology 20021201

• Advances in medical therapy for Crohn's disease.

  Current gastroenterology reports 20021201

• Induction therapy with idarubicin alone significantly influences event-free survival duration in patients with newly diagnosed hypergranular acute promyelocytic leukemia: final results of the GIMEMA randomized study LAP 0389 with 7 years of minimal follow-up.

  Blood 20021101

• Improvement over time in outcome for children with acute lymphoblastic leukemia in second remission given hematopoietic stem cell transplantation from unrelated donors.

  Leukemia 20021101

• Methotrexate polyglutamation may lack prognostic significance in children with B-cell precursor acute lymphoblastic leukemia treated with intensive oral methotrexate.

  Journal of pediatric hematology/oncology 20021101

• Severe pancytopenia from thiopurine methyltransferase deficiency: a preventable complication of 6-mercaptopurine therapy in children with Crohn disease.

  Journal of pediatric gastroenterology and nutrition 20021101

• Recent developments in inflammatory bowel disease.

  The Medical clinics of North America 20021101

• [Resistance to tumor specific therapy with imatinib by clonal selection of mutated cells].

  Deutsche medizinische Wochenschrift (1946) 20021018

• Drug side-effects in IBD.

  Alimentary pharmacology & therapeutics 20021001

• [Individualized therapy with azathioprine or 6-mercaptopurine by monitoring thiopurine methyl-transferase (TPMT) activity].

  Revista clinica espanola 20021001

• [Pharmacogenetic study of thiopurine S-methyltransferase (TPMT) and thiopurine toxicity].

  Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 20021001

• Loss of heterozygosity of p16 correlates with minimal residual disease at the end of the induction therapy in non-high risk childhood B-cell precursor acute lymphoblastic leukemia.

  Leukemia research 20020901

• Thiopurine S-methyltransferase activity in Japanese subjects: metabolic activity of 6-mercaptopurine 6-methylation in different TPMT genotypes.

  Clinica chimica acta; international journal of clinical chemistry 20020901

• The role of posttransplantation maintenance chemotherapy in improving the outcome of autotransplantation in adult acute lymphoblastic leukemia.

  Blood 20020901

• Therapy-related myelodysplastic syndrome or acute myelogenous leukemia in patients with acute promyelocytic leukemia (APL).

  Leukemia 20020901

• Simple chemiluminescence method for the determination of mercaptopurine.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20020901

• 6-Mercaptopurine teratogenicity.

  Postgraduate medical journal 20020901

• Azathioprine or 6-mercaptopurine before colectomy for ulcerative colitis is not associated with increased postoperative complications.

  Inflammatory bowel diseases 20020901

• De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo.

  Blood 20020815

• TPMT in the treatment of Crohn's disease with azathioprine.

  Gut 20020801

• Protagonist: Crohn's disease recurrence can be prevented after ileal resection.

  Gut 20020801

• Immunosuppressants and operation in ulcerative colitis.

  Journal of the American College of Surgeons 20020801

• Combining infliximab with 6-mercaptopurine/azathioprine for fistula therapy in Crohn's disease.

  The American journal of gastroenterology 20020801

• [Progress in the field of hematology in the last 100 years: Medical history of acute leukemia].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20020710

• CD56 expression predicts occurrence of CNS disease in acute lymphoblastic leukemia.

  Leukemia research 20020701

• Review article: maintenance of remission in ulcerative colitis.

  Alimentary pharmacology & therapeutics 20020701

• The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs.

  Molecular pharmacology 20020701

• Leucocyte versus erythrocyte thioguanine nucleotide concentrations in children taking thiopurines for acute lymphoblastic leukaemia.

  Cancer chemotherapy and pharmacology 20020701

• Symptomatic hypoglycemia in children receiving oral purine analogues for treatment of childhood acute lymphoblastic leukemia.

  Medical and pediatric oncology 20020701

• Variant translocations of 11q23 in infant acute lymphoblastic leukemia (ALL): do outcomes differ from t(4;11)?

  Medical and pediatric oncology 20020701

• Increased factor VIII activity and dural sinus thrombosis.

  Medical and pediatric oncology 20020701

• [Development of simplified and rapid detection assay for genetic polymorphisms influencing drug response and its clinical applications].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20020701

• Impact of addition of maintenance therapy to intensive induction and consolidation chemotherapy for childhood acute myeloblastic leukemia: results of a prospective randomized trial, LAME 89/91. Leucámie Aiqüe Myéloïde Enfant.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020615

• Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: possible role of concomitant methotrexate.

  Therapeutic drug monitoring 20020601

• BFM-oriented treatment for children with acute lymphoblastic leukemia without cranial irradiation and treatment reduction for standard risk patients: results of DCLSG protocol ALL-8 (1991-1996).

  Leukemia 20020601

• Recurrence of Langerhans cell histiocytosis in the graft after liver transplantation in adults.

  Transplantation proceedings 20020601

• Forecast for using metabolite measurements in the dosing of azathioprine or 6-mercaptopurine for IBD patients: 'partly cloudy'.

  Gastroenterology 20020601

• [When is drug therapy with azathioprine indicated in Crohn's disease?].

  Deutsche medizinische Wochenschrift (1946) 20020531

• Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemia.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020515

• Teratogen update: azathioprine and 6-mercaptopurine.

  Teratology 20020501

• 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.

  Gastroenterology 20020401

• Review article: monitoring for drug side-effects in inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20020401

• Determination of thiopurine S-methyltransferase phenotype using thin-layer chromatography and quantitative scanning.

  European journal of clinical pharmacology 20020401

• Burkitt's lymphoma: single-centre experience with modified BFM protocol.

  Clinical and laboratory haematology 20020401

• Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia: increased early death after chemotherapy.

  Leukemia 20020201

• Effect of methotrexate polyglutamates on thioguanine nucleotide concentrations during continuation therapy of acute lymphoblastic leukemia with mercaptopurine.

  Leukemia 20020201

• Review article: Immunosuppressants in distal ulcerative colitis.

  Alimentary pharmacology & therapeutics 20020201

• No major cognitive impairment in young children with acute lymphoblastic leukemia using chemotherapy only: a prospective longitudinal study.

  Journal of pediatric hematology/oncology 20020201

• HPLC determination of thiopurine nucleosides and nucleotides in vivo in lymphoblasts following mercaptopurine therapy.

  Clinical chemistry 20020101

• Management of growth retardation in the young patient with Crohn's disease.

  Expert opinion on pharmacotherapy 20020101

• Epstein-Barr virus-positive lymphoma in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine.

  Gastroenterology 20020101

• Recurrent mercaptopurine-induced acute pancreatitis: a rare complication of chemotherapy for acute lymphoblastic leukemia in children.

  Medical and pediatric oncology 20020101

• Prognosis of elderly patients with acute myelogenous leukemia: analysis of 126 AML cases.

  International journal of hematology 20020101

• Philadelphia chromosome-positive acute myeloid leukemia with tetraploidy.

  International journal of hematology 20020101

• Results of a randomized phase III trial in children and adolescents with advanced stage diffuse large cell non-Hodgkin's lymphoma: a Pediatric Oncology Group study.

  Leukemia & lymphoma 20020101

• Pentasomy 8q resulting from duplication of isochromosome 8q in chronic myelomonocytic leukemia.

  Leukemia & lymphoma 20020101

• Intermediate-dose methotrexate and intravenous 6-mercaptopurine chemotherapy for children with acute lymphoblastic leukemia who did not respond to initial induction therapy.

  Journal of pediatric hematology/oncology 20020101

• Do immunosuppressants really work as maintenance therapy after the achievement of remission of severe ulcerative colitis?

  Journal of gastroenterology 20020101

• [Questions and answers on the role of azathioprine and 6-mercaptopurine in the treatment of inflammatory bowel disease].

  Gastroenterologia y hepatologia 20020101

• CD7+ and CD56+ myeloid/natural killer cell precursor acute leukemia treated with idarubicin and cytosine arabinoside.

  Acta haematologica 20020101

• Preconcentration and separation of copper, zinc and cadmium by the use of 6-mercapto purinylazo resin and their application in microwave digested certified biological samples followed by AAS determination of the metal ions.

  Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20020101

• [Results of the treatment of childhood acute lymphoblastic leukemia according to the Berlin-Moscow-91 protocol in 1991-2000].

  Voprosy onkologii 20020101

• The combined effects of antibacterial peptide cecropin A and anti-cancer agents on leukemia cells.

  Anticancer research 20020101

• Comparative pharmacokinetics of oral 6-mercaptopurine and intravenous 6-mercaptopurine riboside in children.

  Pediatrics international : official journal of the Japan Pediatric Society 20011201

• Why measure thiopurine methyltransferase activity? Direct administration of 6-thioguanine might be the alternative for 6-mercaptopurine or azathioprine.

  Gut 20011201

• Avoidance of steroids by the early use of infliximab and 6-mercaptopurine in an adolescent with active Crohn's colitis.

  The American journal of gastroenterology 20011201

• Randomized, double-blind, crossover, placebo-controlled trial of intravenous ondansetron for the prevention of intrathecal chemotherapy-induced vomiting in children.

  Journal of pediatric hematology/oncology 20011201

• Successful treatment of refractory Langerhans cell histiocytosis with unrelated cord blood transplantation.

  Journal of pediatric hematology/oncology 20011201

• Unrelated cord blood transplantation for an infant with chemotherapy-resistant progressive Langerhans cell histiocytosis.

  Journal of pediatric hematology/oncology 20011201

• Continuing therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of methotrexate, 6-mercaptopurine and 6-thioguanine.

  Cancer treatment reviews 20011201

• In vitro bioassays for anticancer drug screening: effects of cell concentration and other assay parameters on growth inhibitory activity.

  Cancer letters 20011108

• Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide.

  Gut 20011101

• Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease.

  Gut 20011101

• Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine.

  Leukemia 20011101

• Pitfalls in the determination of mutant alleles of the thiopurine methyltransferase gene.

  Leukemia 20011101

• Review article: the treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprine.

  Alimentary pharmacology & therapeutics 20011101

• Management of fistulas in patients with Crohn's disease: antibiotic to antibody.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20011101

• Determination of thiopurine methyltransferase activity in human erythrocytes by high-performance liquid chromatography: comparison with the radiochemical method.

  Therapeutic drug monitoring 20011001

• 6-mercaptopurine metabolite levels in children with inflammatory bowel disease.

  Journal of pediatric gastroenterology and nutrition 20011001

• Managing the glucocorticoid dependent inflammatory bowel disease patient.

  Seminars in gastrointestinal disease 20011001

• Medical management of ulcerative proctitis, proctosigmoiditis, and left-sided colitis.

  Seminars in gastrointestinal disease 20011001

• Development of obesity and neurochemical backing in aurothioglucose-treated mice.

  Autonomic neuroscience : basic & clinical 20010917

• Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine.

  The Journal of biological chemistry 20010907

• Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010901

• Therapeutic drug monitoring of cytotoxic drugs.

  British journal of clinical pharmacology 20010901

• Use of azathioprine or 6-mercaptopurine for treatment of steroid-dependent lymphocytic and collagenous colitis.

  The American journal of gastroenterology 20010901

• Therapy-related CD7+ acute myeloid leukemia with trisomy 8 following acute monocytic leukemia.

  Anti-cancer drugs 20010901

• Single-agent therapy with oral mercaptopurine for nonlymphoid blast crisis of chronic myeloid leukemia.

  Annals of hematology 20010901

• Review article: the risk of lymphoma associated with inflammatory bowel disease and immunosuppressive treatment.

  Alimentary pharmacology & therapeutics 20010801

• Glucocorticoids and IL-10, but not 6-MP, 5-ASA or sulfasalazine block endothelial expression of MAdCAM-1: implications for inflammatory bowel disease therapy.

  Alimentary pharmacology & therapeutics 20010801

• Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.

  Cancer research 20010801

• An open-label pilot study using thioguanine as a therapeutic alternative in Crohn's disease patients resistant to 6-mercaptopurine therapy.

  Inflammatory bowel diseases 20010801

• 6-Thioguanine: a naked bullet? (Or how pharmacogenomics can make old drugs brand new).

  Inflammatory bowel diseases 20010801

• Photoactivation of DNA thiobases as a potential novel therapeutic option.

  Current biology : CB 20010724

• Antimycobacterial activity of 9-sulfonylated/sulfenylated-6-mercaptopurine derivatives.

  Bioorganic & medicinal chemistry letters 20010709

• Mechanism of activation of an immunosuppressive drug: azathioprine. Quantum chemical study on the reaction of azathioprine with cysteine.

  Journal of the American Chemical Society 20010704

• A comparison of early intensive methotrexate/mercaptopurine with early intensive alternating combination chemotherapy for high-risk B-precursor acute lymphoblastic leukemia: a Pediatric Oncology Group phase III randomized trial.

  Leukemia 20010701

• Outcome of acute lymphoblastic leukemia in children with AL90 regimen: impact of response to treatment and sex difference on prognostic factors.

  Medical and pediatric oncology 20010701

• If at first you don't succeed...Try again?

  The American journal of gastroenterology 20010701

• Azathioprine for atopic dermatitis.

  Clinical and experimental dermatology 20010701

• Treatment of acute promyelocytic leukaemia using a combination of all-trans retinoic acid and chemotherapy.

  Annals of the Academy of Medicine, Singapore 20010701

• Involvement of the NUP98 gene in a chromosomal translocation t(11;20)(p15;q11.2) in a patient with acute monocytic leukemia (FAB-M5b).

  International journal of hematology 20010701

• Repetitious appearance and disappearance of different kinds of clonal cytogenetic abnormalities after allogeneic bone marrow transplantation.

  International journal of hematology 20010701

• Prognostic impact of CD45 antigen expression in high-risk, childhood B-cell precursor acute lymphoblastic leukemia.

  Leukemia & lymphoma 20010701

• Improved methods for determining the concentration of 6-thioguanine nucleotides and 6-methylmercaptopurine nucleotides in blood.

  Journal of chromatography. B, Biomedical sciences and applications 20010605

• Cost-utility of initial medical management for Crohn's disease perianal fistulae.

  Gastroenterology 20010601

• Magnetic resonance imaging detection of avascular necrosis of the bone in children receiving intensive prednisone therapy for acute lymphoblastic leukemia or non-Hodgkin lymphoma.

  Leukemia 20010601

• Rational dosing of azathioprine and 6-mercaptopurine.

  Gut 20010501

• Treatment of refractory microscopic colitis with azathioprine and 6-mercaptopurine.

  Gastroenterology 20010501

• Conventional treatment of Crohn's disease: objectives and outcomes.

  Inflammatory bowel diseases 20010501

• Approach to corticosteroid-dependent and corticosteroid-refractory Crohn's disease.

  Inflammatory bowel diseases 20010501

• Crohn's disease of the esophagus: clinical features and outcomes.

  Inflammatory bowel diseases 20010501

• Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010415

• Hepatic dysfunction in children with acute lymphoblastic leukemia in remission: relation to hepatitis infection.

  Medical and pediatric oncology 20010401

• Genetic polymorphisms of thiopurine S-methyltransferase and 6-mercaptopurine toxicity in Japanese children with acute lymphoblastic leukaemia.

  Pharmacogenetics 20010401

• Thiopurine methyltransferase activity in the Jewish population of Israel.

  European journal of clinical pharmacology 20010401

• Effect of the glutathione/glutathione disulfide redox couple on thiopurine methyltransferase.

  Biochemical pharmacology 20010315

• High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC.

  Clinical chemistry 20010301

• Fasting hypoglycemia is common during maintenance therapy for childhood acute lymphoblastic leukemia.

  The Journal of pediatrics 20010301

• A novel protein complex distinct from mismatch repair binds thioguanylated DNA.

  Molecular pharmacology 20010201

• Testicular relapse in acute promyelocytic leukaemia.

  British journal of haematology 20010201

• Tautomerism and infrared spectra of 2-thiopurine: an experimental matrix isolation and theoretical ab initio and density functional theory study.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20010201

• Hepatic dysfunction as the presenting feature of acute lymphoblastic leukemia.

  Journal of pediatric hematology/oncology 20010201

• Smooth muscle tumor developing in an immunocompromised child after therapy for leukemia.

  Journal of pediatric hematology/oncology 20010201

• Tumor lysis syndrome in an infant with Langerhans cell histiocytosis successfully treated using continuous arteriovenous hemofiltration.

  Journal of pediatric hematology/oncology 20010201

• Intravenous cyclosporine in refractory pyoderma gangrenosum complicating inflammatory bowel disease.

  Inflammatory bowel diseases 20010201

• New developments in the immunosuppressive drug monitoring of cyclosporine, tacrolimus, and azathioprine.

  Clinical biochemistry 20010201

• Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone.

  Hematology/oncology clinics of North America 20010201

• A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn disease.

  Journal of pediatric gastroenterology and nutrition 20010201

• New bioactive sulfated metabolites from the Mediterranean tunicate Sidnyum turbinatum.

  Journal of natural products 20010201

• Stochastic modeling in toxicokinetics. Application to the in vivo micronucleus assay.

  Mathematical biosciences 20010101

• De novo acute myeloid leukemia in the elderly; a consistent fraction of long-term survivors by standard-dose chemotherapy.

  Leukemia research 20010101

• Molecular dynamics of DNA quadruplex molecules containing inosine, 6-thioguanine and 6-thiopurine.

  Biophysical journal 20010101

• Frequency of use and standards of care for the use of azathioprine and 6-mercaptopurine in the treatment of inflammatory bowel disease: a systematic review of the literature and a survey of Canadian gastroenterologists.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20010101

• WAGR syndrome in a baby--the result of 6-MP treatment in a father affected by Crohn's disease?

  The American journal of gastroenterology 20010101

• Further evidence that 6-MP taken by the father with IBD provides risk of congenital anomaly to the pregnancy.

  The American journal of gastroenterology 20010101

• [Guidelines of the DGVS. Chronic active course. German Society of Digestive and Metabolic Diseases].

  Zeitschrift fur Gastroenterologie 20010101

• Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease.

  Scandinavian journal of gastroenterology 20010101

• 6-mercaptopurine dosage and pharmacokinetics influence the degree of bone marrow toxicity following high-dose methotrexate in children with acute lymphoblastic leukemia.

  Leukemia 20010101

• Severe life-threatening diarrhea caused by azathioprine but not by 6-mercaptopurine.

  Digestion 20010101

• Prognostic value of day 14 blast percentage and the absolute blast index in bone marrow of children with acute lymphoblastic leukemia.

  Pediatric hematology and oncology 20010101

• Intrathecal chemotherapy with antineoplastic agents in children.

  Paediatric drugs 20010101

• [Treatment of acute lymphoblastic leukemia in adults as an unsolved problem].

  Terapevticheskii arkhiv 20010101

• [Experimental study of radiosensitizing effect of analogs of purines and pyrimidine bases in cultured HeLa cells].

  Vestnik Rossiiskoi akademii meditsinskikh nauk 20010101

• Favorable outcome for children and adolescents with T-cell lymphoblastic lymphoma with an intensive ALL-type therapy without local radiotherapy.

  Annals of hematology 20010101

• Late effects of anticancer therapy on kidney function in children with acute lymphoblastic leukemia.

  Bratislavske lekarske listy 20010101

• Recent advances in the pharmacogenomics of thiopurine methyltransferase.

  The pharmacogenomics journal 20010101

• Immune hemolytic anemia induced by 6-mercaptopurine.

  Transfusion 20000101

• Cognitive sequelae in children treated for acute lymphoblastic leukemia with dexamethasone or prednisone.

  Journal of pediatric hematology/oncology 20000101

• Veno-occlusive disease of the liver associated with thiopurines in a child with acute lymphoblastic leukemia.

  Pediatric hematology and oncology 20000101

• Piperacillin-induced seizures.

  Clinical pediatrics 19970801

• Thiopurine methyltransferase activity in the erythrocytes of adults and children: and HPLC-linked assay.

  Clinica chimica acta; international journal of clinical chemistry 19970318

• 6-Mercaptopurine decreases the Bcl-2/Bax ratio and induces apoptosis in activated splenic B lymphocytes.

  Molecular pharmacology 19970301

• Myelodysplastic syndrome following successful therapy of acute promyelocytic leukemia.

  Leukemia 19970101

• The successful treatment of autoimmune hepatitis with 6-mercaptopurine after failure with azathioprine.

  Gastroenterology 19960101

• Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide.

  European journal of clinical pharmacology 19960101

• HPLC analysis of azathioprine metabolites in red blood cells, plasma and urine in renal transplant recipients.

  International journal of clinical pharmacology and therapeutics 19951201

• Low-dose 6-mercaptopurine in inflammatory bowel disease is associated with minimal hematologic toxicity.

  Digestive diseases and sciences 19940801

• Behavioral effects of corticosteroids in children with acute lymphoblastic leukemia.

  Medical and pediatric oncology 19920101

• Protection against isoproterenol-induced myocardial necrosis in rats by 6-mercaptopurine and 6-thioguanine or by irradiation.

  Research communications in chemical pathology and pharmacology 19890301

• Aggressive treatment improves survival in adult acute lymphoblastic leukemia.

  European journal of haematology 19881101

• [Acute pericarditis caused by daunorubicin in acute myelocytic leukemia].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 19880601

• Hepatocellular carcinoma in a long-term survivor of acute lymphocytic leukemia.

  Cancer 19871115

• [Daunomycin-induced cardiogenic shock in a case of acute myelogenous leukemia].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 19870901

• Superior sagittal sinus thrombosis associated with Evans' syndrome of haemolytic anaemia.

  Journal of neurology 19850101

• [Porphyria cutanea tarda caused by methotrexate and buthiopurine therapy].

  Zeitschrift fur Hautkrankheiten 19830215

• Antiviral effects if ribavirin and 6-mercapto-9-tetrahydro-2-furylpurine against dengue viruses in vitro.

  Antiviral research 19820501

• Muscular degeneration in rats after postnatal treatment with 6-mercaptopurine.

  Drug and chemical toxicology 19810101

• [Hemolysis after combined azathioprine and allopurinol therapy].

  Acta medica Austriaca 19790101

• Cytogenetic studies in a patient with acute granulocytic leukemia of seven and one-half years duration.

  Blood 19751101

• [Carcinoma of the liver in a child after seven-year complete remission of acute lymphoblastic leukaemia(author's transl)].

  Deutsche medizinische Wochenschrift (1946) 19750905

• Immunosuppressive and cytotoxic chemotherapy: long-term complications.

  Annals of internal medicine 19750101

• Combination therapy in 130 patients with acute lymphoblastic leukemia (protocol 06 LA 66-Paris).

  Cancer research 19731201

• Anemias with renal transplantation.

  JAMA 19720911

• Hematuria and crystalluria after high-dose 6-mercaptopurine administration.

  The New England journal of medicine 19720810

• Daunorubicin. Results in childhood leukaemia.

  Archives of disease in childhood 19720401

• 6-Azauridine in combination chemotherapy of childhood acute myelocytic leukemia.

  Cancer 19720401

• Clinical note: allergic reaction to daunomycin (NSC-82151).

  Cancer chemotherapy reports 19701201

• Vincristine-induced neuropathy. A clinical study of fifty leukemic patients.

  Neurology 19690401