61350-00-3 | VU 0364770

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$9.00	$6.00
5mg	99%	in stock	$16.00	$11.00
10mg	99%	in stock	$19.00	$14.00
25mg	99%	in stock	$23.00	$17.00
50mg	99%	in stock	$29.00	$20.00
100mg	99%	in stock	$54.00	$38.00
250mg	99%	in stock	$121.00	$85.00

Description

• Catalog Number: AG69236
• Chemical Name: VU 0364770
• CAS Number: 61350-00-3
• Molecular Formula: C12H9ClN2O
• Molecular Weight: 232.6657
• MDL Number: MFCD00548412
• SMILES: Clc1cccc(c1)NC(=O)c1ccccn1

Computed Properties

• Complexity: 247
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 16
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 2.6

Literature

• Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and L-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist.

  Neuropharmacology 20150801

• The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

  The Journal of pharmacology and experimental therapeutics 20120201

• Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).

  Journal of medicinal chemistry 20090723