614-05-1 | Oxythiamine, HCl

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$57.00	$40.00
5g	95%	in stock	$180.00	$126.00
10g	95%	in stock	$331.00	$232.00
25g	95%	in stock	$616.00	$432.00

Description

• Catalog Number: AG65292
• Chemical Name: Oxythiamine, HCl
• CAS Number: 614-05-1
• Molecular Formula: C12H17Cl2N3O2S
• Molecular Weight: 338.2533
• MDL Number: MFCD00050656
• SMILES: OCCc1sc[n+](c1C)Cc1cnc(nc1O)C.[Cl-].Cl

Computed Properties

• Complexity: 395
• Covalently-Bonded Unit Count: 3
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 4

Literature

• Chemical and genetic validation of thiamine utilization as an antimalarial drug target.

  Nature communications 20130101

• Thiamine is a substrate of organic cation transporters in Caco-2 cells.

  European journal of pharmacology 20120505

• New considerations on the neuromodulatory role of thiamine.

  Pharmacology 20120101

• JC virus T-antigen regulates glucose metabolic pathways in brain tumor cells.

  PloS one 20120101

• Profiling pancreatic cancer-secreted proteome using 15N amino acids and serum-free media.

  Pancreas 20100101

• Is transketolase like 1 a target for the treatment of differentiated thyroid carcinoma? A study on thyroid cancer cell lines.

  Investigational new drugs 20090801

• Detection of transketolase in bone marrow-derived insulin-producing cells: benfotiamine enhances insulin synthesis and glucose metabolism.

  Stem cells and development 20090101

• Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.

  Bioorganic & medicinal chemistry letters 20080315

• Involvement of thiaminase II encoded by the THI20 gene in thiamin salvage of Saccharomyces cerevisiae.

  FEMS yeast research 20080301

• Comparative characteristic of thiamine antagonists on apoptosis induction in different types of nerve cell lines.

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20080101

• Thiamine deficiency caused by thiamine antagonists triggers upregulation of apoptosis inducing factor gene expression and leads to caspase 3-mediated apoptosis in neuronally differentiated rat PC-12 cells.

  Acta biochimica Polonica 20070101

• Pentose phosphate cycle oxidative and nonoxidative balance: A new vulnerable target for overcoming drug resistance in cancer.

  International journal of cancer 20061215

• Zinc(II), cadmium(II) and mercury(II) complexes of the vitamin B1 antagonist oxythiamine.

  Journal of inorganic biochemistry 20060101

• Modification of thiamine pyrophosphate dependent enzyme activity by oxythiamine in Saccharomyces cerevisiae cells.

  Canadian journal of microbiology 20051001

• Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids.

  The Journal of biological chemistry 20050318

• C2-alpha-lactylthiamin diphosphate is an intermediate on the pathway of thiamin diphosphate-dependent pyruvate decarboxylation. Evidence on enzymes and models.

  The Journal of biological chemistry 20041224

• Three thiamine analogues differently alter thiamine transport and metabolism in nervous tissue: an in vivo kinetic study using rats.

  Metabolic brain disease 20031201

• Effect of oxythiamin on growth rate, survival ability and pyruvate decarboxylase activity in Saccharomyces cerevisiae.

  Journal of basic microbiology 20030101

• Phenytoin ameliorates the memory deficit induced in the young chick by ethanol toxicity in association with thiamine deficiency.

  Pharmacology, biochemistry, and behavior 20020101

• The effect of thiamine supplementation on tumour proliferation. A metabolic control analysis study.

  European journal of biochemistry 20010801

• The use of thiamine and thiamine antagonists to investigate the etiology of early mortality syndrome in lake trout (Salvelinus namaycush).

  Aquatic toxicology (Amsterdam, Netherlands) 20010501