614-39-1 | 4-amino-N-[2-(diethylamino)ethyl]benzamide hydrochloride

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$19.00	$13.00
1g	95%	in stock	$33.00	$23.00
5g	95%	in stock	$89.00	$62.00
25g	95%	in stock	$249.00	$175.00
100g	95%	in stock	$758.00	$531.00

Description

• Catalog Number: AI53682
• Chemical Name: 4-amino-N-[2-(diethylamino)ethyl]benzamide hydrochloride
• CAS Number: 614-39-1
• Molecular Formula: C13H22ClN3O
• Molecular Weight: 271.7863
• MDL Number: MFCD00012998
• SMILES: CCN(CCNC(=O)c1ccc(cc1)N)CC.Cl
• NSC Number: 757279

Computed Properties

• Complexity: 221
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 6

Literature

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  Biochemical pharmacology 20120515

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  CJEM 20120501

• Fundamentals of ionic conductivity relaxation gained from study of procaine hydrochloride and procainamide hydrochloride at ambient and elevated pressure.

  The Journal of chemical physics 20120428

• Accelerated AV nodal conduction with use of procainamide in atrial fibrillation.

  The Journal of emergency medicine 20120301

• Molecular organization of the non-bilayer phospholipid arrangements that induce an autoimmune disease resembling human lupus in mice.

  Molecular membrane biology 20120301

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  Chembiochem : a European journal of chemical biology 20120102

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  Pediatric emergency care 20120101

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  Kardiologiia 20120101

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  Journal of the American Animal Hospital Association 20120101

• Simultaneous quantitation of nicorandil and its denitrated metabolite in plasma by LC-MS/MS: application for a pharmacokinetic study.

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• Electrochemistry-on-chip for on-line conversions in drug metabolism studies.

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• The evaluation of a novel approach for the profiling and identification of N-linked glycan with a procainamide tag by HPLC with fluorescent and mass spectrometric detection.

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• Efforts to improve detection sensitivity for capillary electrophoresis coupled to atmospheric pressure photoionization mass spectrometry.

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  Circulation journal : official journal of the Japanese Circulation Society 20100501

• Association of the Ottawa Aggressive Protocol with rapid discharge of emergency department patients with recent-onset atrial fibrillation or flutter.

  CJEM 20100501

• Amiodarone versus procainamide for the acute treatment of recurrent supraventricular tachycardia in pediatric patients.

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• Combination antiarrhythmic therapy: 1 + 1 > 2?

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• Developing procedures for the large-scale purification of human serum butyrylcholinesterase.

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• Forskolin, an inducer of cAMP, up-regulates acetylcholinesterase expression and protects against organophosphate exposure in neuro 2A cells.

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  The Journal of biological chemistry 20051209

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  Electrophoresis 20020601

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  European journal of pharmacology 20020510

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  Arthritis and rheumatism 20020501

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  Polish journal of pharmacology 20020101

• Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide.

  Cancer research 20011215

• New electrocardiographic leads and the procainamide test for the detection of the Brugada sign in sudden unexplained death syndrome survivors and their relatives.

  European heart journal 20011201

• In vitro production of antibodies to histones in patients receiving chronic procainamide therapy.

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  Pacing and clinical electrophysiology : PACE 20010701

• Acoustic and optical transduction of BuChE binding to procainamide modified surfaces.

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• Intravenous administration of class I antiarrhythmic drugs induced T wave alternans in a patient with Brugada syndrome.

  Journal of cardiovascular electrophysiology 20010401

• Role of K+ channels in N-acetylprocainamide-induced relaxation of bovine tracheal smooth muscle.

  European journal of pharmacology 20010309

• Comparison of the effects on drug concentrations, electrophysiologic parameters, and termination of atrial fibrillation in dogs when procainamide and ibutilide are delivered into the right atrium versus intravenously.

  Journal of cardiovascular electrophysiology 20010301

• Intravenous antiarrhythmic agents.

  Current opinion in cardiology 20010101

• Issues in the use of generic antiarrhythmic drugs.

  Current opinion in cardiology 20010101

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  Muscle & nerve 20010101

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  Critical reviews in immunology 20010101

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  Lupus 20010101

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  Proceedings of the Western Pharmacology Society 20010101

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  Journal of UOEH 19990901

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  American journal of therapeutics 19990901

• Comparison of propafenone versus procainamide for the acute treatment of atrial fibrillation after cardiac surgery.

  The American journal of cardiology 19990801

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  Circulation 19990427

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  American journal of kidney diseases : the official journal of the National Kidney Foundation 19981001

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  Annals of the New York Academy of Sciences 19980513

• Procainamide-induced chronic inflammatory demyelinating polyradiculoneuropathy.

  Neurology 19980301

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  Cardiovascular drugs and therapy 19980301

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  Pediatric cardiology 19950101

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  American heart journal 19950101

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  Journal of cardiovascular electrophysiology 19940501

• Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs.

  JAMA 19931201

• Study of procainamide hapten-specific antibodies in rabbits and humans.

  International journal of immunopharmacology 19931101

• Respiratory failure from procainamide-induced myopathy.

  Annals of internal medicine 19930815

• Procainamide-induced myasthenia-like weakness and dysphagia.

  Therapeutic drug monitoring 19930601

• Possible case of procainamide-induced intrahepatic cholestatic jaundice.

  The Annals of pharmacotherapy 19930401

• Myasthenia gravis by another name: an elusive imposter.

  Survey of ophthalmology 19930101

• Polymorphic ventricular tachycardia induced by programmed stimulation: response to procainamide.

  Journal of the American College of Cardiology 19930101

• Autoantibodies associated with lupus induced by diverse drugs target a similar epitope in the (H2A-H2B)-DNA complex.

  The Journal of clinical investigation 19920701

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  The American journal of cardiology 19920115

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  Circulation research 19910801

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  The American journal of cardiology 19910415

• Myotonia congenita (Thomsen's disease) report of five cases in a family.

  Paediatrica Indonesiana 19910101

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  Canadian journal of physiology and pharmacology 19910101

• Intrahepatic cholestasis due to hypersensitivity reaction to procainamide.

  Archives of internal medicine 19901201

• Synthesis and cardiac electrophysiological activity of aryl-substituted derivatives of the class III antiarrhythmic agent sematilide. Potential class I/III agents.

  Journal of medicinal chemistry 19900201

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  Farmakologiia i toksikologiia 19900101

• Facilitation of ventricular tachycardia initiation by procainamide during programmed ventricular stimulation in patients with heart failure.

  Journal of electrocardiology 19900101

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  The American journal of the medical sciences 19891201

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  Vnitrni lekarstvi 19891101

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  The American journal of medicine 19890501

• A comparison of sotalol and procainamide in symptomatic ventricular tachycardia.

  Cardiovascular drugs and therapy 19890401

• Pulmonary thromboembolism associated with procainamide induced lupus syndrome and anticardiolipin antibodies.

  Annals of the rheumatic diseases 19890301

• Procainamide-induced urticarial vasculitis.

  Cutis 19881101

• Procainamide administration during electrophysiology study--utility as a provocative test for intermittent atrioventricular block.

  Pacing and clinical electrophysiology : PACE 19881001

• Prediction of successful suppression of sustained ventricular tachyarrhythmias by serial drug testing from data derived at the initial electrophysiologic study.

  Journal of the American College of Cardiology 19881001

• Respiratory failure produced by severe procainamide intoxication in a patient with preexisting peripheral neuropathy caused by amiodarone.

  Chest 19880901

• Procainamide induced lupus anticoagulant.

  Wisconsin medical journal 19880901

• Clinical characteristics of patients with ventricular fibrillation during antiarrhythmic drug therapy.

  The New England journal of medicine 19880804

• Procainamide-induced lupus anticoagulants and thrombosis.

  Southern medical journal 19880201

• Heart failure and lactic acidosis associated with oral procainamide.

  Acute care 19880101

• Mania associated with procainamide.

  The American journal of psychiatry 19880101

• Enhanced antiarrhythmic efficacy of propafenone when used in combination with procainamide or quinidine.

  American heart journal 19870901

• Pure red cell aplasia associated with administration of sustained-release procainamide.

  Archives of internal medicine 19870601

• Proarrhythmic effects of antiarrhythmic drugs during programmed ventricular stimulation in patients without ventricular tachycardia.

  Journal of the American College of Cardiology 19870201

• 'Doom anxiety' and delirium in lidocaine toxicity.

  The American journal of psychiatry 19870201

• Antiarrhythmic effects of indecainide in a drug-resistant population with ventricular tachycardia at programmed electrical stimulation.

  American heart journal 19870101

• Effects of four antiarrhythmic drugs on the induction and termination of paroxysmal supraventricular tachycardia.

  Japanese circulation journal 19861001

• Procainamide-induced incessant supraventricular tachycardia in the Wolff-Parkinson-White syndrome.

  Pacing and clinical electrophysiology : PACE 19860901

• Procainamide-induced myasthenia-like syndrome.

  Muscle & nerve 19860901

• Simultaneous appearance of endocardial late potentials and ability to induce sustained ventricular tachycardia after procainamide administration.

  Journal of electrocardiology 19860401

• Myopathy after short term administration of procainamide.

  British medical journal (Clinical research ed.) 19860301

• Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death.

  Research communications in chemical pathology and pharmacology 19860301

• Tremor induced by procainamide.

  The American journal of cardiology 19860201

• Procainamide induced sustained monomorphic ventricular tachycardia in a patient with benign premature ventricular complexes.

  The Canadian journal of cardiology 19860101

• Procainamide-induced lupus with vasculitis.

  Clinical and experimental rheumatology 19860101

• The beneficial effect of amrinone on acute drug-induced heart failure in the anaesthetised dog.

  Cardiovascular research 19850801

• Torsades de pointes due to n-acetylprocainamide.

  Pacing and clinical electrophysiology : PACE 19850701

• Torsade de pointes associated with elevated N-acetylprocainamide levels.

  American heart journal 19850201

• Suspected procainamide-induced angioedema.

  Drug intelligence & clinical pharmacy 19850201

• Drug-induced torsade de pointes.

  Clinical pharmacy 19850101

• Polymorphic ventricular tachycardia and ventricular fibrillation due to N-acetyl procainamide.

  The American journal of cardiology 19850101

• Procainamide-induced hypotension during CPR.

  Clinical pharmacy 19850101

• Psychosis induced by sustained-release procainamide.

  Canadian Medical Association journal 19841115

• Cerebellar ataxia due to procainamide toxicity.

  Archives of internal medicine 19841101

• Positive direct antiglobulin tests and immune hemolytic anemia in patients receiving procainamide.

  The New England journal of medicine 19840927

• Antiarrhythmic action of bethanidine.

  The American journal of cardiology 19840801

• Magnesium therapy for torsades de pointes.

  The American journal of cardiology 19840201

• Myocarditis resolving after discontinuation of procainamide.

  International journal of cardiology 19831001

• Reticulocytopenic, coombs' positive anemia induced by procainamide.

  American journal of clinical pathology 19830701

• Effective plasma concentrations of antiarrhythmic drugs against sustained halothane-adrenaline arrhythmia in dogs.

  Journal of cardiovascular pharmacology 19830101

• [Anti-arrhythmia properties of pyromecaine].

  Farmakologiia i toksikologiia 19830101

• The response to procainamide during electrophysiologic study for sustained ventricular tachyarrhythmias predicts the response to other medications.

  Circulation 19830101

• Torsades de pointes, a common arrhythmia, induced by medication.

  Canadian Medical Association journal 19820901

• Cardiovascular effects of quinidine and procainamide on intact dogs and isolated cross-perfused canine atria.

  Journal of cardiovascular pharmacology 19820101

• Procainamide-induced myasthenia-like weakness in a patient with peripheral neuropathy.

  Archives of neurology 19810601

• Procainamide-induced polymorphous ventricular tachycardia.

  The American journal of cardiology 19810601

• Renal manifestations of drug-induced systemic lupus erythematosus.

  American journal of clinical pathology 19810501

• Procainamide and peripheral neuropathy.

  Southern medical journal 19810401

• Efficacy, plasma concentrations and adverse effects of a new sustained release procainamide preparation.

  The American journal of cardiology 19801101

• Procainamide-induced lupus erythematosus pericarditis encountered during coronary bypass sugery.

  The American journal of medicine 19800701

• Procainamide-induced myositis.

  Journal of the neurological sciences 19800201

• Procainamide-induced sinus node dysfunction in patients with chronic renal failure.

  Chest 19791201

• Procainamide and the sinus node.

  Chest 19791201

• Glomerulonephritis in procainamide induced lupus erythematosus: report of a case and review of the literature.

  Journal of clinical & laboratory immunology 19790401

• Nephrotic syndrome in procainamide induced lupus nephritis.

  Clinical nephrology 19790401

• Atypical ventricular tachycardia as a manifestation of disopyramide toxicity.

  The American journal of cardiology 19781201

• Procainamide-induced psychosis.

  JAMA 19780915

• Effect of procainamide on induced ventricular tachycardia.

  Clinical pharmacology and therapeutics 19780901

• Procainamide-induced left anterior hemiblock of the 2:1 type (pseudoelectrical alternans).

  Chest 19780801

• Reversible severe anaemia and granulocytopenia caused by procainamide. A case report.

  Scandinavian journal of haematology 19780801

• A comparison of the effects of quinetholate, lidocaine and procainamide on ouabain-induced ventricular tachycardia and cardiac function.

  Archives internationales de pharmacodynamie et de therapie 19780401

• Procainamide-induced hemolytic anemia.

  Transfusion 19780101

• Circulating anticoagulant in the procainamide-induced lupus syndrome.

  Archives of internal medicine 19771001

• Clinical consequences of polymorphic acetylation of basic drugs.

  Clinical pharmacology and therapeutics 19770901

• Cumulation of N-acetylprocainamide, an active metabolite of procainamide, in patients with impaired renal function.

  Clinical pharmacology and therapeutics 19770701

• Polyradiculoneuropathy accompanying procainamide-induced lupus erythematosus: evidence for drug-induced enhanced sensitization to peripheral nerve myelin.

  Annals of neurology 19770401

• Drug-induced lupus erythematosus.

  Arizona medicine 19770301

• Electrophysiological studies in left bundle branch block as a result of procainamide therapy.

  JPMA. The Journal of the Pakistan Medical Association 19760201

• Use of cardioactive drugs in acute myocardial infarction.

  Heart & lung : the journal of critical care 19760101

• Pharmacologically active drug metabolites: therapeutic and toxic activities, plasma and urine data in man, accumulation in renal failure.

  Clinical pharmacokinetics 19760101

• Procainamide and phenytoin. Comparative study of their antiarrhythmic effects at apparent therapeutic plasma levels.

  British heart journal 19750701

• Vascular effects of procaine amide in the dog. Predominance of the inhibitory effect on ganglionic transmission.

  Circulation research 19741201

• Effect of procaine amide, quinidine, and ajmaline in the Wolff-Parkinson-White syndrome.

  Circulation 19740701

• Antiarrhythmic drug therapy for sporadic ventricular ectopic arrhythmias.

  Circulation 19740401

• A comparison of the experimental anti-arrhythmic properties of acebutolol (M and B 17,803), propranolol and practolol.

  British journal of pharmacology 19740301

• Long-term use of procaine amide following acute myocardial infarction.

  Circulation 19730601

• Procainamide-induced systemic lupus erythematosus.

  Rheumatology and rehabilitation 19730501

• Drug-induced lupus syndrome presenting as pericardia effusion.

  Le Journal medical libanais. The Lebanese medical journal 19730101

• Treatment of ventricular tachycardia in an infant.

  Canadian Medical Association journal 19720722

• Cardiac tamponade in procainamide induced lupus erythematosus.

  Chest 19720601

• Procainamide-induced pericardial effusion.

  American heart journal 19720601

• Systemic lupus erythematosus during treatment with procainamide.

  British heart journal 19720301

• Bretylium tosylate in treatment of refractory ventricular arrhythmias complicating myocardial infarction.

  British heart journal 19700101

• Delirium induced by a combination of anti-arrhythmic drugs.

  Lancet (London, England) 19691220

• Case report: successful treatment of ventricular tachycardia associated with thioridazine (Mellaril).

  Southern medical journal 19690301

• Clofibrate-induced ventricular arrhythmia.

  The American journal of cardiology 19690201

• Angiitis following procainamide therapy. Case report.

  Missouri medicine 19680501

• Antiarrhythmic activity of some isoquinoline derivatives determined by a rapid screening procedure in the mouse.

  The Journal of pharmacology and experimental therapeutics 19680301

• [Comparative antiarrhythmic and antitoxic activity of beta-hexamethyleneimino-para-butoxypropiophenone, novocaine amide and quinidine in arrhythmia, induced by calcium chlorides in mice].

  Farmakologiia i toksikologiia 19680101

• Vasculitis following procaine amide therapy.

  The American journal of medicine 19670401

• Electrocardiographic patterns of procaine amide cardiotoxicity.

  The American journal of the medical sciences 19670101

• The effect of diphenylhydantoin sodium (dilantin), procaine hydrochloride, procaine amide hydrochloride, and quinidine hydrochloride upon ouabain-induced ventricular tachycardia in unanesthetized dogs.

  Circulation 19540701