62-44-2 | Phenacetin

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$15.00	$10.00
5g	95%	in stock	$16.00	$11.00
25g	95%	in stock	$23.00	$16.00
100g	95%	in stock	$74.00	$52.00
500g	95%	in stock	$251.00	$176.00

Description

• Catalog Number: AB51640
• Chemical Name: Phenacetin
• CAS Number: 62-44-2
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.21572000000003
• MDL Number: MFCD00009094
• SMILES: CCOc1ccc(cc1)NC(=O)C

Computed Properties

• Complexity: 162
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• XLogP3: 1.6

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  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071101

• Characterization of tableting using the OSDRC system.

  Pharmaceutical research 20071001

• [Effect of Qingkailing injection on rat CYP1A2 and CYP2D6 activity].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071001

• Properties of pellets manufactured by wet extrusion/spheronization process using kappa-carrageenan: effect of process parameters.

  AAPS PharmSciTech 20071001

• Bladder tumor associated with phenacetin abuse: a case report and a review of the literature.

  The Tokai journal of experimental and clinical medicine 20070920

• Acute spinal cord injury changes the disposition of some, but not all drugs given intravenously.

  Spinal cord 20070901

• A validated high-performance liquid chromatographic method for the determination of moclobemide and its two metabolites in human plasma and application to pharmacokinetic studies.

  Biomedical chromatography : BMC 20070901

• In vitro assessment of cytochrome P450 inhibition: strategies for increasing LC/MS-based assay throughput using a one-point IC(50) method and multiplexing high-performance liquid chromatography.

  Journal of pharmaceutical sciences 20070901

• Effect of acetaminophen, a cyclooxygenase inhibitor, on Morris water maze task performance in mice.

  Journal of psychopharmacology (Oxford, England) 20070901

• Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in rats.

  Biological & pharmaceutical bulletin 20070901

• Analgesic nephropathy.

  Kidney international 20070801

• Analgesic nephropathy selectively affecting a unilateral non-functioning hypoplastic kidney.

  Clinical nephrology 20070801

• Evidence on unusual way of cocaine smuggling: cocaine-polymethyl methacrylate (PMMA) solid solution--study of clandestine laboratory samples.

  Forensic science international 20070704

• In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies.

  Journal of mass spectrometry : JMS 20070701

• Validated method for rapid inhibition screening of six cytochrome P450 enzymes by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601

• An optimized analytical method of fluconazole in human plasma by high-performance liquid chromatography with ultraviolet detection and its application to a bioequivalence study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601

• In vitro cytotoxicity assay with selected chemicals using human cells to predict target-organ toxicity of liver and kidney.

  Toxicology in vitro : an international journal published in association with BIBRA 20070601

• Epidemiology of urinary bladder cancer: from tumor development to patient's death.

  World journal of urology 20070601

• [Simultaneous determination of the inhibitory potency of compounds on the activity of five cytochrome P-450 enzymes using a cocktail probe substrates method].

  Yao xue xue bao = Acta pharmaceutica Sinica 20070601

• Nonsteroidal antiinflammatory drug use and risk of bladder cancer in the health professionals follow-up study.

  International journal of cancer 20070515

• Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC-MS/MS analysis.

  Journal of pharmaceutical and biomedical analysis 20070509

• In memoriam 'analgesic nephropathy' (circa 1972-2006).

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070401

• [Study on the potential impact of bromomethane on medicinal products following simulated container fumigation].

  Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 20070401

• Stereoselective analysis of hydroxybupropion and application to drug interaction studies.

  Chirality 20070301

• CYP2A13 metabolizes the substrates of human CYP1A2, phenacetin, and theophylline.

  Drug metabolism and disposition: the biological fate of chemicals 20070301

• Microemulsion electrokinetic chromatography with on-line atmospheric pressure photoionization mass spectrometric detection.

  Analytical chemistry 20070215

• A toxicogenomic approach revealed hepatic gene expression changes mechanistically linked to drug-induced hemolytic anemia.

  Toxicological sciences : an official journal of the Society of Toxicology 20070201

• Impaired clearance of phenacetin in hepatic cirrhosis and fibrosis.

  International journal of clinical pharmacology and therapeutics 20070101

• Glomerulocystic kidney disease and its rare associations: an autopsy report of two unrelated cases.

  Diagnostic pathology 20070101

• Effects of nebulized ketamine on allergen-induced airway hyperresponsiveness and inflammation in actively sensitized Brown-Norway rats.

  Journal of inflammation (London, England) 20070101

• Arthritis and pain. Future targets to control osteoarthritis pain.

  Arthritis research & therapy 20070101

• Acetaminophen, phenacetin and dipyrone do not modulate pressor responses to arachidonic Acid or to pressor agents.

  Pharmacology 20070101

• Analgesic and anti-inflammatory drug use and risk of bladder cancer: a population based case control study.

  BMC urology 20070101

• Quantitation of nimesulide in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection and its application to a bioequivalence study.

  Arzneimittel-Forschung 20070101

• Analgesics use and ESRD in younger age: a case-control study.

  BMC nephrology 20070101

• Piroxicam-induced hepatic and renal histopathological changes in mice.

  The Libyan journal of medicine 20070101

• Rofecoxib is a potent, metabolism-dependent inhibitor of CYP1A2: implications for in vitro prediction of drug interactions.

  Drug metabolism and disposition: the biological fate of chemicals 20061201

• cDNA cloning and characterization of feline CYP1A1 and CYP1A2.

  Life sciences 20061125

• Elucidation of the effects of the CYP1A2 deficiency polymorphism in the metabolism of 4-cyclohexyl-1-ethyl-7-methylpyrido[2,3-d]pyrimidine-2-(1h)-one (YM-64227), a phosphodiesterase type 4 inhibitor, and its metabolites in dogs.

  Drug metabolism and disposition: the biological fate of chemicals 20061101

• Obituary to analgesic nephropathy--an autopsy study.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20061101

• Towards an understanding of the molecular mechanism of solvation of drug molecules: a thermodynamic approach by crystal lattice energy, sublimation, and solubility exemplified by paracetamol, acetanilide, and phenacetin.

  Journal of pharmaceutical sciences 20061001

• Characterization of CYP1A enzyme in Adélie penguin liver.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20061001

• Kinetic study of paracetamol on prolidase activity in erythrocytes by capillary electrophoresis with Ru(bpy)(3) (2+) electrochemiluminescence detection.

  Electrophoresis 20061001

• An evaluation of para toluene-sulfonamide metabolism and effect with regard to CYP isoforms, P-glycoprotein, and drug interactions.

  Die Pharmazie 20061001

• Solubility parameter of drugs for predicting the solubility profile type within a wide polarity range in solvent mixtures.

  International journal of pharmaceutics 20060914

• Radial basis function neural networks in non-destructive determination of compound aspirin tablets on NIR spectroscopy.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060901

• Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20060901

• Use of analgesics and nonsteroidal anti-inflammatory drugs, genetic predisposition, and bladder cancer risk in Spain.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20060901

• [Tissue-like cultures of rat hepatocytes in study of phase I and phase II drug metabolism].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20060901

• Identification of phenacetin metabolites in human urine after administration of phenacetin-C2H3: measurement of futile metabolic deacetylation via HPLC/MS-SPE-NMR and HPLC-ToF MS.

  Xenobiotica; the fate of foreign compounds in biological systems 20060701

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Non-contrast-enhanced computerized tomography and analgesic-related kidney disease: report of the national analgesic nephropathy study.

  Journal of the American Society of Nephrology : JASN 20060501

• Determination of compound aminopyrine phenacetin tablets by using artificial neural networks combined with principal components analysis.

  Analytical biochemistry 20060415

• Phenacetin acts as a weak genotoxic compound preferentially in the kidney of DNA repair deficient Xpa mice.

  Mutation research 20060411

• Determination of AKF-PD in whole blood of rat by HPLC-UV.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060403

• Serum sickness-like reaction to Pamabrom.

  Journal of drugs in dermatology : JDD 20060301

• Thalidomide enantiomers: determination in biological samples by HPLC and vancomycin-CSP.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060202

• Understanding drug disposition alterations induced by acute spinal cord injury: role of injury level and route of administration for agents submitted to extensive liver metabolism.

  Journal of neurotrauma 20060101

• [Effect of some non-steroidal antiinflammatory drugs and isomeric dihydroxy benzoic acids on the AAPH initiated degradation of crocin].

  Acta pharmaceutica Hungarica 20060101

• Interaction of thioamides, selenoamides, and amides with diiodine.

  Bioinorganic chemistry and applications 20060101

• Measurement of human cytochrome P4501A2 (CYP1A2) activity in vitro.

  Current protocols in toxicology 20060101

• Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention.

  The Journal of pharmacology and experimental therapeutics 20051201

• Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer agents.

  Bioorganic & medicinal chemistry letters 20051201

• The history of barbiturates a century after their clinical introduction.

  Neuropsychiatric disease and treatment 20051201

• Automated assessment of time-dependent inhibition of human cytochrome P450 enzymes using liquid chromatography-tandem mass spectrometry analysis.

  Drug metabolism and disposition: the biological fate of chemicals 20051101

• Spectroscopic investigation of the novel charge-transfer complex [(phen)(TCNE)(12)] formed in the reaction of phenacetin with tetracyanoethylene.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051101

• [The combined effect of isoniazid and rifampicin on the activities of CYP4501A2 and CYP4503A4 in primary hepatocytes from healthy human adults].

  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20051101

• Biomarker measurements in a coastal fish-eating population environmentally exposed to organochlorines.

  Environmental health perspectives 20051001

• Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa.

  Drug metabolism and disposition: the biological fate of chemicals 20050801

• Long-term erythropoietin therapy improves response in myelodysplastic syndrome.

  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20050801

• Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography.

  Journal of biomolecular screening 20050801

• The use of a substrate cassette strategy to improve the capacity and throughput of cytochrome P450 induction studies in human hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20050701

• Thermodynamic study of the transfer of acetanilide and phenacetin from water to different organic solvents.

  Acta pharmaceutica (Zagreb, Croatia) 20050601

• Controlled release of drug via methylcellulose-carboxyvinylpolymer interpolymer complex solid dispersion.

  AAPS PharmSciTech 20050601

• Selective inhibition of dog hepatic CYP2B11 and CYP3A12.

  The Journal of pharmacology and experimental therapeutics 20050501

• PCB exposure and in vivo CYP1A2 activity among Native Americans.

  Environmental health perspectives 20050301

• Molecular cloning and functional analysis of cytochrome P450 1A2 from Japanese monkey liver: comparison with marmoset cytochrome P450 1A2.

  Chemico-biological interactions 20050227

• Preparative synthesis of drug metabolites using human cytochrome P450s 3A4, 2C9 and 1A2 with NADPH-P450 reductase expressed in Escherichia coli.

  Journal of industrial microbiology & biotechnology 20050201

• War syndromes: the impact of culture on medically unexplained symptoms.

  Medical history 20050101

• Prevalence of von Hippel-Lindau gene mutations in sporadic renal cell carcinoma: results from The Netherlands cohort study.

  BMC cancer 20050101

• HPLC and TLC methodology for determination or purity evaluation of 4-methoxy-2-(3(4-phenyl-1-piperazinyl))propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine.

  Acta poloniae pharmaceutica 20050101

• Case-control study on analgesics and nephropathy (SAN): protocol.

  BMC nephrology 20050101

• High-throughput screening of inhibitory potential of nine cytochrome P450 enzymes in vitro using liquid chromatography/tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20050101

• Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841].

  Malaria journal 20050101

• [Effect of some nonsteroid antiinflammatory drugs on Fenton-reaction initiated degradation of 2-deoxy-D-ribose].

  Acta pharmaceutica Hungarica 20050101

• Generic three-column parallel LC-MS/MS system for high-throughput in vitro screens.

  Journal of chromatography. A 20041126

• Quinones as antimycobacterial agents.

  Bioorganic & medicinal chemistry 20040915

• [Examination of the stability of hydrogen peroxide solutions].

  Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20040901

• Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison.

  Xenobiotica; the fate of foreign compounds in biological systems 20040901

• [Determination of three components in compound acetylsalicylic acid tablet by dual-wavelength ratio spectrometry].

  Guang pu xue yu guang pu fen xi = Guang pu 20040701

• Validated assays for human cytochrome P450 activities.

  Drug metabolism and disposition: the biological fate of chemicals 20040601

• Phenacetin and chlorzoxazone biotransformation in aging male Fischer 344 rats.

  The Journal of pharmacy and pharmacology 20040601

• [Prevention of bladder cancer].

  Der Urologe. Ausg. A 20040501

• Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes.

  Xenobiotica; the fate of foreign compounds in biological systems 20040501

• Phenacetin and cocaine in a body packer.

  Forensic science international 20040420

• Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes.

  Life sciences 20040416

• Analgesic nephropathy in Hungary: the HANS study.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040401

• Induction of diphenytriazol on cytochrome CYP1A.

  Acta pharmacologica Sinica 20040401

• In vitro metabolism and inductive or inhibitive effect of DL111 on rat cytochrome P4501A enzyme.

  Chemico-biological interactions 20040315

• Evaluation of the patient with hematuria.

  The Medical clinics of North America 20040301

• Phase I and II enzyme characterization of two sources of HepG2 cell lines.

  Xenobiotica; the fate of foreign compounds in biological systems 20040301

• Sex-dependent modulation of treatment response.

  Dialogues in clinical neuroscience 20040301

• Atomoxetine hydrochloride: clinical drug-drug interaction prediction and outcome.

  The Journal of pharmacology and experimental therapeutics 20040201

• Functional characterization of four allelic variants of human cytochrome P450 1A2.

  Archives of biochemistry and biophysics 20040201

• Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes.

  The Journal of pharmacology and experimental therapeutics 20040101

• Interaction of cyclooxygenase isoenzymes, nitric oxide, and afferent neurons in gastric mucosal defense in rats.

  The Journal of pharmacology and experimental therapeutics 20040101

• Antipyretic therapy.

  Frontiers in bioscience : a journal and virtual library 20040101

• Evaluation of the Xpa-deficient transgenic mouse model for short-term carcinogenicity testing: 9-month studies with haloperidol, reserpine, phenacetin, and D-mannitol.

  Toxicologic pathology 20040101

• 13C-breath tests in the study of microsomal liver function.

  European review for medical and pharmacological sciences 20040101

• High-performance liquid chromatography/inductively coupled plasma mass spectrometry and tandem mass spectrometry for the detection of carbon-containing compounds.

  Rapid communications in mass spectrometry : RCM 20040101

• Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study.

  Breast cancer research : BCR 20040101

• Rapid determination of five probe drugs and their metabolites in human plasma and urine by liquid chromatography/tandem mass spectrometry: application to cytochrome P450 phenotyping studies.

  Rapid communications in mass spectrometry : RCM 20040101

• Use of a cocktail of probe substrates for drug-metabolizing enzymes for the assessment of the metabolic capacity of hepatocyte preparations.

  Xenobiotica; the fate of foreign compounds in biological systems 20040101

• Phenacetin and analgesic mixtures containing phenacetin.

  Report on carcinogens : carcinogen profiles 20040101

• Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain.

  Biochemistry 20031209

• 'Open access' generic method for continuous determination of major human CYP450 probe substrates/metabolites and its application in drug metabolism studies.

  Xenobiotica; the fate of foreign compounds in biological systems 20031201

• Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.

  Drug metabolism and disposition: the biological fate of chemicals 20031101

• Assessment of tableting properties using infinitesimal quantities of powdered medicine.

  International journal of pharmaceutics 20030916

• HPLC analyses and pharmacokinetic studies of baicalin and oxymatrine in rabbits.

  Die Pharmazie 20030901

• Analgesics and renal disease in the postphenacetin era.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20030801

• Identification of CYP1A2 as the main isoform for the phase I hydroxylated metabolism of genistein and a prodrug converting enzyme of methylated isoflavones.

  Drug metabolism and disposition: the biological fate of chemicals 20030701

• Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation.

  Drug metabolism and disposition: the biological fate of chemicals 20030701

• Effects of phenacetin and its metabolite p-phenetidine on COX-1 and COX-2 activities and expression in vitro.

  Thrombosis research 20030615

• [Novel potential uses of thalidomide in the management of pain? A review of the literature].

  Schmerz (Berlin, Germany) 20030601

• Caffeine as a promoter of analgesic-associated nephropathy--where is the evidence?

  Fundamental & clinical pharmacology 20030601

• Determination of matrine in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies.

  Talanta 20030410

• Identification of cytochrome P450 1A2 as enzyme involved in the microsomal metabolism of Huperzine A.

  European journal of pharmacology 20030214

• Simultaneous liquid chromatography-tandem mass spectrometric determination of albendazole sulfoxide and albendazole sulfone in plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030105

• High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20030101

• Epidemiology of non-steroidal anti-inflammatory drugs and cancer.

  Progress in experimental tumor research 20030101

• Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis.

  BMC cancer 20030101

• In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole.

  Drug metabolism and pharmacokinetics 20030101

• Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions.

  Drug metabolism and disposition: the biological fate of chemicals 20021201

• Validated HPLC method for determination of chlorzoxazone in human serum and its application in a clinical pharmacokinetic study.

  Die Pharmazie 20021201

• Monolithic silica rod liquid chromatography with ultraviolet or fluorescence detection for metabolite analysis of cytochrome P450 marker reactions.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021125

• Phenotype of CYP2C19 and CYP3A4 by determination of omeprazole and its two main metabolites in plasma using liquid chromatography with liquid-liquid extraction.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021125

• Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs.

  The Journal of pharmacology and experimental therapeutics 20021101

• Hydrogen bonding with adsorbent during storage governs drug dissolution from solid-dispersion granules.

  Pharmaceutical research 20021101

• Polymer particle erosion controlling drug release. II. Swelling investigations to clarify the release mechanism.

  International journal of pharmaceutics 20021024

• COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression.

  Proceedings of the National Academy of Sciences of the United States of America 20021015

• Correlation between induction of DNA fragmentation in urinary bladder cells from rats and humans and tissue-specific carcinogenic activity.

  Toxicology 20020930

• Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method.

  Drug metabolism and disposition: the biological fate of chemicals 20020801

• Evaluation of the surfactant properties of ascorbyl palmitate sodium salt.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020701

• Method development and validation of a high-performance liquid chromatographic method for tramadol in human plasma using liquid-liquid extraction.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020525

• [A case of renal pelvic tumor due to phenacetin abuse].

  Hinyokika kiyo. Acta urologica Japonica 20020501

• Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.

  Biochemical pharmacology 20020301

• [Simultaneous determination of four components in the compound child phenobarbital tablet using ultraviolet spectrophotometry].

  Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20020227

• Cytochrome p450 assays.

  Current protocols in pharmacology 20020201

• A straightforward means of coupling preparative high-performance liquid chromatography and mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20020101

• PISA. The effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute stroke: protocol for a phase II double-blind randomised placebo-controlled trial [ISRCTN98608690].

  BMC cardiovascular disorders 20020101

• The onset of action and the analgesic efficacy of Saridon (a propyphenazone/paracetamol/ caffeine combination) in comparison with paracetamol, ibuprofen, aspirin and placebo (pooled statistical analysis).

  Current medical research and opinion 20020101

• Comparison of vasoconstrictor responses to selected NSAIDs in rabbit renal and femoral arteries.

  Bratislavske lekarske listy 20020101

• Phenacetin O-deethylation in extrahepatic tissues of rats.

  European journal of drug metabolism and pharmacokinetics 20020101

• In vivo effect of diallyl sulfide and cimetidine on phenacetin metabolism and bioavailability in rat.

  Acta biochimica Polonica 20020101

• Use of analgesics in self-medication.

  Therapie 20020101

• Decreased hepatic drug metabolising enzyme activity in rats with nitrosamine-induced tumours.

  Drug metabolism and drug interactions 20020101

• Fondaparinux sodium is not metabolised in mammalian liver fractions and does not inhibit cytochrome P450-mediated metabolism of concomitant drugs.

  Clinical pharmacokinetics 20020101

• Alteration of phenacetin pharmacokinetics after experimental spinal cord injury.

  Proceedings of the Western Pharmacology Society 20020101

• Hospitalized poisonings after renal transplantation in the United States.

  BMC nephrology 20020101

• Renal papillary necrosis.

  Toxicologic pathology 20020101

• Drug-induced hepatitis with hepatic granuloma due to saridon.

  Journal of gastroenterology 20020101

• Renal PGE2 production in the human and rat following phenacetin, acetaminophen and p-aminophenol.

  Research communications in molecular pathology and pharmacology 20020101

• Phenacetin.

  Report on carcinogens : carcinogen profiles 20020101

• Analgesic mixtures containing phenacetin.

  Report on carcinogens : carcinogen profiles 20020101

• Identification of inhibitory component in cinnamon--O-methoxycinnamaldehyde inhibits CYP1A2 and CYP2E1-.

  Drug metabolism and pharmacokinetics 20020101

• Application of microtiter plate assay to evaluate inhibitory effects of various compounds on nine cytochrome P450 isoforms and to estimate their inhibition patterns.

  Drug metabolism and pharmacokinetics 20020101

• Kinetic impact of presystemic intestinal metabolism on drug absorption: experiment and data analysis for the prediction of in vivo absorption from in vitro data.

  Drug metabolism and pharmacokinetics 20020101

• Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20011201

• Relationship between nonphenacetin combined analgesics and nephropathy.

  Kidney international 20011101

• [Etiopathology, risk factors, environmental influences and epidemiology of bladder cancer].

  Der Urologe. Ausg. A 20011101

• Differential inhibition of human CYP1A1 and CYP1A2 by quinidine and quinine.

  Xenobiotica; the fate of foreign compounds in biological systems 20011101

• Review of potential risk factors for kidney (renal cell) cancer.

  Seminars in urologic oncology 20011101

• Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.

  Immunopharmacology and immunotoxicology 20011101

• In vitro metabolism of tegaserod in human liver and intestine: assessment of drug interactions.

  Drug metabolism and disposition: the biological fate of chemicals 20011001

• A case of phenacetin-induced skin cancer in Hong Kong.

  Hong Kong medical journal = Xianggang yi xue za zhi 20010901

• 'No, Duke. No divorce'.

  Medical economics 20010820

• Detailed characterization of experimentally derived human hepatic CYP1A1 activity and expression using differential inhibition of ethoxyresorufin O-deethylation by fluvoxamine.

  European journal of clinical pharmacology 20010801

• [Simultaneous determination of aspirin, phenacetin and caffeine in compound APC by derivative ratio UV adsorption spectrum method].

  Guang pu xue yu guang pu fen xi = Guang pu 20010801

• A rapid reversed phase high performance liquid chromatographic method for determination of etoposide (VP-16) in human plasma.

  Journal of pharmaceutical and biomedical analysis 20010601

• Relationship between nonphenacetin-combined analgesics and nephropathy.

  Kidney international 20010601

• Relationship between nonphenacetin-combined analgesics and nephropathy.

  Kidney international 20010601

• Relationship between nonphenacetin-combined analgesics and nephropathy.

  Kidney international 20010601

• Relationship between nonphenacetin-combined analgesics and nephropathy.

  Kidney international 20010601

• [Analgesics-induced chronic renal failure in patients on dialysis therapy in Hungary].

  Orvosi hetilap 20010513

• Optimization of an exogenous metabolic activation system for FETAX. II. Preliminary evaluation.

  Drug and chemical toxicology 20010501

• Polymer particle erosion controlling drug release. I. Factors influencing drug release and characterization of the release mechanism.

  International journal of pharmaceutics 20010417

• Oxidations of p-alkoxyacylanilides catalyzed by human cytochrome P450 1A2: structure-activity relationships and simulation of rate constants of individual steps in catalysis.

  Biochemistry 20010410

• [Determination of three components in compound chlorophenamine tablet by iterative target transformation factor analysis].

  Guang pu xue yu guang pu fen xi = Guang pu 20010401

• Suppression of agglomeration in fluidized bed coating. IV. Effects of sodium citrate concentration on the suppression of particle agglomeration and the physical properties of HPMC film.

  International journal of pharmaceutics 20010314

• Trends of analgesic nephropathy in two high-endemic regions with different legislation.

  Journal of the American Society of Nephrology : JASN 20010301

• Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline.

  Xenobiotica; the fate of foreign compounds in biological systems 20010301

• Interindividual variations in levels and activities of cytochrome P-450 in liver microsomes of Chinese subjects.

  Acta pharmacologica Sinica 20010301

• Analysis of the phase solubility diagram of a phenacetin/competitor/beta-cyclodextrin ternary system, involving competitive inclusion complexation.

  Chemical & pharmaceutical bulletin 20010101

• Xpa and Xpa/p53+/- knockout mice: overview of available data.

  Toxicologic pathology 20010101

• Neonatal mouse model: review of methods and results.

  Toxicologic pathology 20010101

• The syrian hamster embryo (SHE) cell transformation assay: review of the methods and results.

  Toxicologic pathology 20010101

• Tg.AC genetically altered mouse: assay working group overview of available data.

  Toxicologic pathology 20010101

• [Optimal conditions for extraction of 'caffetin' and 'saridon' tablet components from aqueous solutions].

  Sudebno-meditsinskaia ekspertiza 20010101

• A population approach to enzyme characterization and identification: application to phenacetin O-deethylation.

  Pharmaceutical research 20001201

• Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants.

  Biochemistry 20000919

• Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human hepatocytes: a 10-year follow-up.

  Xenobiotica; the fate of foreign compounds in biological systems 20000601

• Reduction of hydroxamic acids to the corresponding amides catalyzed by rabbit blood.

  Xenobiotica; the fate of foreign compounds in biological systems 20000501

• In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6.

  British journal of clinical pharmacology 20000401

• Epidemiology and etiology of premalignant and malignant urothelial changes.

  Scandinavian journal of urology and nephrology. Supplementum 20000101

• Regular use of analgesics is a risk factor for renal cell carcinoma.

  British journal of cancer 19991001

• Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice.

  Toxicological sciences : an official journal of the Society of Toxicology 19990701

• Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.

  The Journal of pharmacology and experimental therapeutics 19980201

• Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans.

  Archives of toxicology 19970101

• Intermolecular interactions of antimicrobial fluoroquinolones with purified rat liver CYP1A2 studied by proton nuclear magnetic resonance spectroscopy.

  Xenobiotica; the fate of foreign compounds in biological systems 19961001

• Habitual use of acetaminophen as a risk factor for chronic renal failure: a comparison with phenacetin.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 19960701

• Metabolism of the food derived mutagen and carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) by human liver microsomes.

  Carcinogenesis 19940601

• [Paracetamol--kidney and urinary tract. A cause of analgetic nephropathy or cancer?].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 19940420

• Different roles for phenacetin and paracetamol in cancer of the kidney and renal pelvis.

  International journal of cancer 19930121

• Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.

  Drug metabolism and disposition: the biological fate of chemicals 19930101

• Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2.

  Archives of biochemistry and biophysics 19920501

• The role of N-hydroxyphenetidine in phenacetin-induced hemolytic anemia.

  Toxicology and applied pharmacology 19911001

• An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987).

  The New England journal of medicine 19910117

• [A case of chronic renal failure caused by 20-year intake of pyrcophen].

  Klinicheskaia meditsina 19900801

• The Copenhagen case-control study of renal pelvis and ureter cancer: role of analgesics.

  International journal of cancer 19891215

• Analgesic use and chronic renal disease.

  The New England journal of medicine 19890511

• Progression of renal failure in analgesic-associated nephropathy.

  Nephron 19890101

• Metabolic oxidation of the carcinogens 4-aminobiphenyl and 4,4'-methylene-bis(2-chloroaniline) by human hepatic microsomes and by purified rat hepatic cytochrome P-450 monooxygenases.

  Cancer research 19890101

• Does paracetamol cause urothelial cancer or renal papillary necrosis?

  Nephron 19880101

• Polymorphism of human cytochrome P-450.

  Xenobiotica; the fate of foreign compounds in biological systems 19870301

• Age-related sensitivity of rats to induction of anaemia.

  Folia haematologica (Leipzig, Germany : 1928) 19870101

• Renal disease from habitual antipyretic analgesic consumption: an assessment of the epidemiologic evidence.

  Medicine 19860901

• N-hydroxy-2-acetylaminofluorene as effective inhibitor of aldehyde oxidase.

  Biochemical and biophysical research communications 19860716

• Analgesic and non-steroidal anti-inflammatory drug-associated acute renal failure: a prospective collaborative study.

  Clinical nephrology 19860601

• Drug- and chemical-induced methaemoglobinaemia. Clinical features and management.

  Medical toxicology 19860101

• Relation of analgesic use to renal cancer: population-based findings.

  National Cancer Institute monograph 19851201

• Heavy phenacetin use and bladder cancer in women aged 20 to 49 years.

  The New England journal of medicine 19850801

• Acute abstinence syndrome after epidural injection of butorphanol.

  Anesthesia and analgesia 19850401

• [Capillarosclerosis of the efferent urinary tract as an indication of analgesic abuse. Incidence in unselected autopsies in a large West German town].

  Deutsche medizinische Wochenschrift (1946) 19850301

• Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis.

  IARC scientific publications 19840101

• The influence of phenacetin or mechanical perforation on the development of renal pelvic and urinary bladder tumors in FANFT-induced urinary tract carcinogenesis.

  Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology 19830901

• A new reproducible experimental model of analgesic nephropathy.

  The Journal of pathology 19830101

• Analgesics and cancer of the renal pelvis in New South Wales.

  Cancer 19820615

• Optic atrophy after propoxyphene overdose: report of a case.

  Annals of ophthalmology 19820601

• Nephropathy as a hazard of analgesic abuse.

  American journal of hospital pharmacy 19811001

• Hepatotoxicity of phenacetin and paracetamol in the Gunn rat.

  Pathology 19811001

• Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine.

  Acta pathologica et microbiologica Scandinavica. Section A, Pathology 19810501

• Analgesic nephropathy induced by common proprietary mixtures.

  The Medical journal of Australia 19800517

• Nephrotoxicity of mild analgesics in the Gunn strain of rat.

  British journal of clinical pharmacology 19800101

• Eighteen month oral study of aspirin, phenacetin and caffeine, in C57Bl/6 mice.

  Drug and chemical toxicology 19800101

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  Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 19790101

• Experimental renal papillary necrosis.

  Kidney international 19780101

• Analgesic nephropathy in Canada: clinical syndrome, management, and outcome.

  Kidney international 19780101

• Aspirin, phenacetin, and the kidney: a rheumatism clinic study.

  The Medical journal of Australia 19770625

• Dyskinesia after discountinuation of compound analgesic containing oxycodone.

  Lancet (London, England) 19770402

• [Side effects of nalidixic acid in a patient with severe renal failure. Clinical study and proposal of a pharmacokinetic model].

  Schweizerische medizinische Wochenschrift 19770305

• Analgesic-induced renal papillary necrosis in the Gunn rat: the comparative nephrotoxicity of aspirin and phenacetin.

  The Journal of pathology 19761101

• Phenacetin-induced sulfhemoglobinemia: report of a case and review of the literature.

  The Johns Hopkins medical journal 19761001

• Constrictive pericarditis due to methysergide therapy.

  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 19760925

• Studies on the modification of renal lesions due to aspirin and oxyphenbutazone in the rat and the effects on the kidney of 2:4 dinitrophenol.

  Pathology 19760701

• Pathology, aetiology and pathogenesis of analgesic nephropathy.

  Australian and New Zealand journal of medicine 19760101

• Letter: The clinical course of patients with analgesic nephropathy.

  Canadian Medical Association journal 19750809

• The radiological diagnosis of analgesic nephropathy.

  Clinical radiology 19750701

• Analgesic abuse, ureteric obstruction, and retroperitoneal fibrosis.

  British medical journal 19750412

• The induction of renal papillary necrosis in Gunn rats by analgesics and analgesic mixtures.

  British journal of experimental pathology 19750201

• Effect of 3-methylcholanthrene treatment on phenacetin O-dealkylation in several inbred mouse strains.

  Drug metabolism and disposition: the biological fate of chemicals 19750101

• The degradation of paracetamol (4-hydroxyacetanilide) and other substituted acetanilides by a Penicillium species.

  Antonie van Leeuwenhoek 19750101

• Phenacetin-induced methemoglobinemia and renal failure.

  Anesthesiology 19740701

• Aspirin and the kidney. New Zealand Rheumatism Association Study.

  British medical journal 19740330

• The origins of analgesic nephropathy.

  The British journal of psychiatry : the journal of mental science 19730701

• Ureteric stricture with analgesic nephropathy.

  British medical journal 19730505

• Renal pelvic tumour associated with analgesic abuse.

  Canadian Medical Association journal 19721021

• Papillary necrosis in the Gunn rat: rapid induction by analgesics.

  Pathology 19720701

• Comparative nephrotoxicity of aspirin and phenacetin derivatives.

  British medical journal 19711127

• Analgesic nephropathy: clinical syndrome and prognosis.

  British medical journal 19710227

• Clonixin: a clinical evaluation of a new oral analgesic.

  The Journal of clinical pharmacology and new drugs 19710101

• Phenacetin nephropathy, with particular reference to the effect of surgery.

  British medical journal 19701017

• Papillary necrosis in rats caused by aspirin and aspirin-containing mixtures.

  British medical journal 19700905

• Analgesic abuse in psychiatric patients.

  Lancet (London, England) 19700620

• [Kidney disorders caused by various drugs and metals, with special reference to epitetracycline and phenacetin].

  Saishin igaku. Modern medicine 19680910

• Syndrome associated with the abuse of analgesics.

  Annals of internal medicine 19680401

• Analgesic nephropathy.

  Lancet (London, England) 19680323

• Lesions in the vasa recta in experimental analgesic nephropathy.

  Lancet (London, England) 19680106

• Short-term study of the effect of phenacetin, phenazone and amidopyrine on the rat kidney.

  British journal of pharmacology and chemotherapy 19680101

• The toxicity of phenacetin at the range of the oral LD50(100 days) in albino rats.

  Toxicology and applied pharmacology 19680101

• Renal papillary necrosis following phenacetin excess.

  Scottish medical journal 19670701

• Paracetamol and the kidney.

  British medical journal 19670603

• IS PHENACETIN A NEPHROTOXIN?A REPORT ON TWENTY-THREE USERS OF THE DRUG.

  California medicine 19640801