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The cytochrome P450 inhibitor SKF-525A disrupts autophagy in primary rat hepatocytes.
Chemico-biological interactions 20160805
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Proadifen sensitizes resistant ovarian adenocarcinoma cells to cisplatin.
Toxicology letters 20160122
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Effect of fipronil on energy metabolism in the perfused rat liver.
Toxicology letters 20150702
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Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes.
Journal of applied toxicology : JAT 20140801
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Inhibition of GSK-3β reverses the pro-apoptotic effect of proadifen (SKF-525A) in HT-29 colon adenocarcinoma cells.
Toxicology in vitro : an international journal published in association with BIBRA 20120901
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Isolation of gentiopicroside from Gentianae Radix and its pharmacokinetics on liver ischemia/reperfusion rats.
Journal of ethnopharmacology 20120601
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Subepithelial trypsin induces enteric nerve-mediated anion secretion by activating proteinase-activated receptor 1 in the mouse cecum.
The journal of physiological sciences : JPS 20120501
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Cancer prevention mediated by caffeic acid phenethyl ester involves cyp2b1/2 modulation in hepatocarcinogenesis.
Toxicologic pathology 20120401
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Microsomal oxidative damage promoted by acetaminophen metabolism.
Toxicology in vitro : an international journal published in association with BIBRA 20111001
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Enantioselective carbonyl reduction of eperisone in human liver microsomes.
Xenobiotica; the fate of foreign compounds in biological systems 20110901
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Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 20110801
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Metabolism of dl-praeruptorin A in rat liver microsomes using HPLC-electrospray ionization tandem mass spectrometry.
Archives of pharmacal research 20110801
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Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity.
Cardiovascular research 20110501
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[Mechanism related to docosahexaenoic acid induced large conductance calcium-activated potassium channel currents increase in coronary smooth muscle cells].
Zhonghua xin xue guan bing za zhi 20110401
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Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats.
Journal of applied toxicology : JAT 20110301
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Identification of clinically used drugs that activate pregnane X receptors.
Drug metabolism and disposition: the biological fate of chemicals 20110101
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Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 20101101
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The nicotinic acetylcholine receptor and the Na,K-ATPase alpha2 isoform interact to regulate membrane electrogenesis in skeletal muscle.
The Journal of biological chemistry 20100910
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Methyl palmitate: a potent vasodilator released in the retina.
Investigative ophthalmology & visual science 20100901
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Adrenic acid metabolites as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors.
Hypertension (Dallas, Tex. : 1979) 20100201
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Role of metabolism in 1-bromopropane-induced hepatotoxicity in mice.
Journal of toxicology and environmental health. Part A 20100101
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Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20091201
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nature chemical biology 20091001
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The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms.
British journal of pharmacology 20090701
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A novel administration route for edaravone: I. Effects of metabolic inhibitors on skin permeability of edaravone.
International journal of pharmaceutics 20090508
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The relationship between diphenylamine structure and NSAIDs-induced hepatocytes injury.
Toxicology letters 20090425
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Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism.
The Journal of pharmacy and pharmacology 20090101
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2-Diethylaminoethyl-2,2-diphenylvalerate-HCl (SKF525A) revisited: comparative cytochrome P450 inhibition in human liver microsomes by SKF525A, its metabolites, and SKF-acid and SKF-alcohol.
Drug metabolism and disposition: the biological fate of chemicals 20081201
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Synthesis and biological evaluation of amide derivatives of (5,6-dimethoxy-2,3-dihydro-1H-inden-1-yl)acetic acid as anti-inflammatory agents with reduced gastrointestinal ulcerogenecity.
European journal of medicinal chemistry 20081001
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Influence of brain-derived neurotrophic factor (BDNF) on serotonin neurotransmission in the hippocampus of adult rodents.
European journal of pharmacology 20080610
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Neuromedin U inhibits inflammation-mediated memory impairment and neuronal cell-death in rodents.
Neuroscience research 20080501
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Identification of human cytochrome P450 enzymes involved in the metabolism of IN-1130, a novel activin receptor-like kinase-5 (ALK5) inhibitor.
Xenobiotica; the fate of foreign compounds in biological systems 20080501
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Synthesis and biological evaluation of amide derivatives of (6-Chloro-2,3-dihydro-1H-inden-1-yl)acetic acid as potential anti-inflammatory agents with lower gastrointestinal toxicity.
Chemical & pharmaceutical bulletin 20080501
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Negative inotropic effect of selective AT2 receptor stimulation and its modulation by the endocardial endothelium.
European journal of pharmacology 20080114
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In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors.
Drug metabolism and disposition: the biological fate of chemicals 20071001
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Pharmacokinetics of intravenous methotrexate in mutant Nagase analbuminemic rats.
Biopharmaceutics & drug disposition 20071001
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Identification of a tryptanthrin metabolite in rat liver microsomes by liquid chromatography/electrospray ionization-tandem mass spectrometry.
Biological & pharmaceutical bulletin 20071001
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Characterization of benidipine and its enantiomers' metabolism by human liver cytochrome P450 enzymes.
Drug metabolism and disposition: the biological fate of chemicals 20070901
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Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione.
Toxicology 20070603
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Zinc-mediated neuronal death is dependent on Trk activation.
Experimental neurology 20070601
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A new technique for assaying cytochrome P450 enzyme activity in a single cell.
Cell biology and toxicology 20070501
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Pharmacokinetics of 5-fluorouracil in mutant Nagase analbuminemic rats: faster metabolism of 5-fluorouracil via CYP1A.
Biopharmaceutics & drug disposition 20070301
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Elevated warfarin metabolism in warfarin-resistant roof rats (Rattus rattus) in Tokyo.
Drug metabolism and disposition: the biological fate of chemicals 20070101
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Hydroxyeicosatetraenoic acids released through the cytochrome P-450 pathway regulate 3T6 fibroblast growth.
Journal of lipid research 20061201
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Metabolism of pyrene by aquatic crustacean, Daphnia magna.
Aquatic toxicology (Amsterdam, Netherlands) 20061116
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Analytical approach to determine ticlopidine in post-mortem blood.
Forensic science international 20061016
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Altered arachidonic acid-mediated responses in the perfused kidney of the streptozotocin-induced diabetic rat.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20061001
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Inhibition of cytochrome P-450 with 2-diethylamino-ethyl-2,2-diphenylpropylacetate (SKF-525A) reduces immunotoxicity of chlorinated carbohydrates.
Bulletin of experimental biology and medicine 20060901
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Enhancement of DMNQ-induced hepatocyte toxicity by cytochrome P450 inhibition.
Toxicology and applied pharmacology 20060715
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Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous omeprazole in rats.
Biopharmaceutics & drug disposition 20060701
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Inhibition of PGI2 signaling by miconazole in vascular smooth muscle cells.
Prostaglandins & other lipid mediators 20060701
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Participation of epoxygenase activation in saikogenin D-induced inhibition of prostaglandin E(2) synthesis.
The Journal of pharmacy and pharmacology 20060601
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Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
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Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20060315
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Site specificity of agonist-induced opening and desensitization of the Torpedo californica nicotinic acetylcholine receptor.
Biochemistry 20060110
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Involvement of phenobarbital and SKF 525A in the hepatotoxicity of antifungal drugs itraconazole and fluconazole in rats.
Drug and chemical toxicology 20060101
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Increased cell-cell adhesion, a novel effect of R-(-)-deprenyl.
Journal of neural transmission (Vienna, Austria : 1996) 20051101
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Augmentation of lipogenesis by 15-deoxy-Delta12,14-prostaglandin J2 in hamster sebaceous glands: identification of cytochrome P-450-mediated 15-deoxy-Delta12,14-prostaglandin J2 production.
The Journal of investigative dermatology 20051101
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Endothelium-dependent and direct relaxation induced by ethyl acetate extract from Flos Chrysanthemi in rat thoracic aorta.
Journal of ethnopharmacology 20051003
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Effect of cytochrome P450 inhibitors and anticonvulsants on the acute toxicity of acrylonitrile.
Archives of toxicology 20051001
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In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations in human liver microsomes: a comparison with SKF-525A.
Drug metabolism and pharmacokinetics 20051001
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Metabolism of the alpha,beta-unsaturated ketones, chalcone and trans-4-phenyl-3-buten-2-one, by rat liver microsomes and estrogenic activity of the metabolites.
Drug metabolism and disposition: the biological fate of chemicals 20050801
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[Role of endothelium-derived hyperpolarizing factor in shear stress-induced endothelium-dependent relaxations of rats].
Yao xue xue bao = Acta pharmaceutica Sinica 20050601
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Identification of cytochrome P450 forms involved in the 4-hydroxylation of valsartan, a potent and specific angiotensin II receptor antagonist, in human liver microsomes.
Xenobiotica; the fate of foreign compounds in biological systems 20050601
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Role of nitric oxide during coronary endothelial dysfunction after myocardial infarction.
European journal of pharmacology 20050523
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Properties and regional expression of a CYP3A-like protein in channel catfish intestine.
Aquatic toxicology (Amsterdam, Netherlands) 20050515
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Connexin26 is responsible for anionic molecule permeability in the cochlea for intercellular signalling and metabolic communications.
The European journal of neuroscience 20050401
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Excretion and metabolism of DA-7867, a new oxazolidinone, in rats.
Biopharmaceutics & drug disposition 20050301
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Primary hepatocyte apoptosis is unlikely to relate to caspase-3 activity under sustained endogenous oxidative stress.
Free radical research 20050201
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Essential role of singlet oxygen species in cytochrome P450-dependent substrate oxygenation by rat liver microsomes.
Drug metabolism and pharmacokinetics 20050201
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Skf 525-A induces cocaine N-demethylase, ethoxyresorufin O-deethylase, and pentoxyresorufin O-dealkylase activities by induction of cytochrome p-450 2B in female B6C3F1 mice.
Journal of toxicology and environmental health. Part A 20041201
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Pharmacokinetics of baicalin in rats and its interactions with cyclosporin A, quinidine and SKF-525A: a microdialysis study.
Planta medica 20041101
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In vitro confirmation of selegiline N-oxidation by flavin-containing monooxygenase in rat microsome using LC-ESI MS.
Biological & pharmaceutical bulletin 20041001
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Pharmacokinetic factors in sex differences in Delta 9-tetrahydrocannabinol-induced behavioral effects in rats.
Behavioural brain research 20040923
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Mechanisms of hydroxyl radical-induced contraction of rat aorta.
European journal of pharmacology 20040919
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Characterization of endothelium-dependent relaxation and modulation by treatment with pioglitazone in the hypercholesterolemic rabbit renal artery.
European journal of pharmacology 20040830
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Chlorpropham induces mitochondrial dysfunction in rat hepatocytes.
Toxicology 20040805
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Lipoxygenase-dependent superoxide release in skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985) 20040801
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Hepatobiliary excretion of berberine.
Drug metabolism and disposition: the biological fate of chemicals 20040401
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Microbial transformations of chalcones: hydroxylation, O-demethylation, and cyclization to flavanones.
Journal of natural products 20040401
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Antiandrogenic activities of diesel exhaust particle extracts in PC3/AR human prostate carcinoma cells.
Toxicological sciences : an official journal of the Society of Toxicology 20031201
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In vivo identification of aflatoxin-induced free radicals in rat bile.
Free radical biology & medicine 20031115
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Metabolism of medroxyprogesterone acetate (MPA) via CYP enzymes in vitro and effect of MPA on bleeding time in female rats in dependence on CYP activity in vivo.
Life sciences 20031107
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Rapid stimulation of free glucuronate formation by non-glucuronidable xenobiotics in isolated rat hepatocytes.
The Journal of biological chemistry 20030919
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Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes.
Environmental toxicology 20030801
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Cytochrome p-450 epoxygenase products contribute to attenuated vasoconstriction after chronic hypoxia.
American journal of physiology. Heart and circulatory physiology 20030701
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11,12-epoxyeicosatrienoic acid attenuates synthesis of prostaglandin E2 in rat monocytes stimulated with lipopolysaccharide.
Experimental biology and medicine (Maywood, N.J.) 20030701
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Involvement of cytochrome P450 and the flavin-containing monooxygenase(s) in the sulphoxidation of simple sulphides in human liver microsomes.
Life sciences 20030606
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The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats.
Free radical biology & medicine 20030601
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Effects of cytochrome P450 inhibitors on agonist-induced Ca2+ responses and production of NO and PGI2 in vascular endothelial cells.
Molecular and cellular biochemistry 20030601
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Concurrent corticosteroid and phenanthrene transformation by filamentous fungus Cunninghamella elegans.
The Journal of steroid biochemistry and molecular biology 20030501
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Regulation of hepatobiliary excretion of sinomenine by P-glycoprotein in Sprague-Dawley rats.
Life sciences 20030411
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Arachidonic acid in astrocytes blocks Ca(2+) oscillations by inhibiting store-operated Ca(2+) entry, and causes delayed Ca(2+) influx.
Cell calcium 20030401
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Role of metabolism by flavin-containing monooxygenase in thioacetamide-induced immunosuppression.
Toxicology letters 20030113
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Assessment of mazindane, a pro-drug form of mazindol, in assays used to define cocaine treatment agents.
European journal of pharmacology 20030105
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Effect of ketamine on cocaine-induced immunotoxicity in rats.
International journal of toxicology 20030101
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In vivo detection of aflatoxin-induced lipid free radicals in rat bile.
Biochimica et biophysica acta 20021010
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Inhibition of cocaine oxidative metabolism attenuates endotoxin potentiation of cocaine mediated hepatotoxicity.
Toxicology 20020930
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In vitro and in vivo formation of aminophenylnorharman from norharman and aniline.
Mutation research 20020930
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Effects of gap junction uncoupling in the gerbil cochlea.
The Laryngoscope 20020901
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Paraquat detoxicative system in the mouse liver postmitochondrial fraction.
Archives of biochemistry and biophysics 20020601
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Chemiluminescence associated with the oxidative metabolism of salicylic acid in rat liver microsomes.
Chemico-biological interactions 20020520
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Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids.
Circulation research 20020517
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Toxicity of ethacrynic acid in isolated rat hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA 20020401
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Production of carbon monoxide by cytochrome P450 during iron-dependent lipid peroxidation.
Toxicology in vitro : an international journal published in association with BIBRA 20020201
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The influence of metabolism on the MAO-B inhibitory potency of selegiline.
Current medicinal chemistry 20020101
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Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes.
The Journal of pharmacology and experimental therapeutics 20011201
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Sex-dependent toxicity of a novel acyl-CoA:cholesterol acyltransferase inhibitor, YIC-C8-434, in relation to sex-specific forms of cytochrome P450 in rats.
Toxicological sciences : an official journal of the Society of Toxicology 20011201
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Possible mechanisms for the suppressing action of 17beta-estradiol on beta-adrenoceptor-mediated vasorelaxation in rat aorta.
European journal of pharmacology 20010907
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Perinatal development influences mechanisms of bradykinin-induced relaxations in pulmonary resistance and conduit arteries differently.
Cardiovascular research 20010701
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The role of enzyme induction and inhibition on cypermethrin hepatotoxicity.
Pharmacological research 20010701
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Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect.
American journal of physiology. Heart and circulatory physiology 20010601
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Microsomal metabolism of ciprofloxacin generates free radicals.
Free radical biology & medicine 20010515
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Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids.
The Journal of biological chemistry 20010511
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Cytochrome p450-dependent metabolism of trichloroethylene in rat kidney.
Toxicological sciences : an official journal of the Society of Toxicology 20010301
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Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways.
Journal of neurochemistry 20010301
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The role of desensitisation in decay time of miniature endplate currents in frogs Rana ridibunda and Rana temporaria.
Neuroscience research 20010301
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A conformational intermediate between the resting and desensitized states of the nicotinic acetylcholine receptor.
The Journal of biological chemistry 20010216
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Role of copper ions and cytochrome P450 in the vasodilator actions of the nitroxyl anion generator, Angeli's salt, on rat aorta.
European journal of pharmacology 20010202
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Anti-apoptotic and apoptotic action of (-)-deprenyl and its metabolites.
Journal of neural transmission (Vienna, Austria : 1996) 20010101
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[Role of phospholipase A2 and epoxygenase in inhibition of respiration burst in neutrophils by low intensity radiation of extremely high frequency].
Biofizika 20010101
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Low-density lipoprotein induced actin cytoskeleton reorganization in endothelial cells: mechanisms of action.
Endothelium : journal of endothelial cell research 20010101
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Understanding channel blocking in the nicotinic acetylcholine receptor.
Receptors & channels 20010101
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Deciphering the plasma membrane hallmarks of apoptotic cells: phosphatidylserine transverse redistribution and calcium entry.
BMC cell biology 20010101
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[Effect of arachidonic and other fatty acids on the intracellular calcium concentration and calcium signaling in peritoneal macrophages].
Tsitologiia 20010101
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Metabolism of nonylphenol by rat and human microsomes.
Toxicology letters 19981015
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Styrene metabolism in Exophiala jeanselmei and involvement of a cytochrome P-450-dependent styrene monooxygenase.
Applied and environmental microbiology 19960401
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Acute cytogenetic effect of benzene on rat bone marrow cells in vivo and the effect of inducers or inhibitors of drug-metabolizing enzymes.
Mutation research 19921201
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Influence of agents affecting monooxygenase activity on taurolithocholic acid-induced cholestasis.
Toxicology letters 19921201
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Dose-dependent cytotoxicity of chlorinated hydrocarbons in isolated rat hepatocytes.
Fundamental and applied toxicology : official journal of the Society of Toxicology 19900501
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Correlation between the induction of micronuclei in bone marrow by benzene exposure and the excretion of metabolites in urine of CD-1 mice.
Toxicology and applied pharmacology 19860930
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Cytotoxicity of halogenated alkanes in primary cultures of rat hepatocytes from normal, partial hepatectomized, and preneoplastic/neoplastic liver.
Toxicology and applied pharmacology 19850915
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Modifications in the myeloclastogenic effect of benzene in mice with toluene, phenobarbital, 3-methylcholanthrene, Aroclor 1254 and SKF-525A.
Mutation research 19840301
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Effect of pretreatment with phenobarbital or SKF 525A on the toxicity and antitumor activity of lomustine.
Cancer treatment reports 19830301
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Influence of alterations in drug metabolism on spontaneous and epinephrine-induced cardiac arrhythmias in animals exposed to trichloroethylene.
Toxicology and applied pharmacology 19790315
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Cholinesterase inhibition by phenothiazine and nonphenothiazine antihistaminics: analysis of its postulated role in synergizing organophosphate toxicity.
Toxicology and applied pharmacology 19750201
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The etiology of methoxyflurane nephrotoxicity.
The Journal of pharmacology and experimental therapeutics 19740901
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Propanil (3,4-dichloropropionanilide)-induced methemoglobin formation in mice in relation to acylamidase activity.
Toxicology and applied pharmacology 19730501
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Protection by spironolactone and oxandrolone against chronic digitoxin or indomethacin intoxication.
Toxicology and applied pharmacology 19710301
