621-42-1 | 3-Acetamidophenol

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$15.00	$10.00
10g	98%	in stock	$18.00	$12.00
25g	98%	in stock	$23.00	$16.00
100g	98%	in stock	$63.00	$44.00
500g	98%	in stock	$244.00	$171.00

Description

• Catalog Number: AI53831
• Chemical Name: 3-Acetamidophenol
• CAS Number: 621-42-1
• Molecular Formula: C8H9NO2
• Molecular Weight: 151.16256
• MDL Number: MFCD00002263
• SMILES: CC(=O)Nc1cccc(c1)O

Computed Properties

• Complexity: 147
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 0.7

Literature

• Proteomic profiling in incubation medium of mouse, rat and human precision-cut liver slices for biomarker detection regarding acute drug-induced liver injury.

  Journal of applied toxicology : JAT 20140901

• Covalent modification and time-dependent inhibition of human CYP2E1 by the meta-isomer of acetaminophen.

  Drug metabolism and disposition: the biological fate of chemicals 20120801

• Gene expression in rat hearts following oral administration of a single hepatotoxic dose of acetaminophen.

  Yonsei medical journal 20120101

• Oral exposure to drugs with immune-adjuvant potential induces hypersensitivity responses to the reporter antigen TNP-OVA.

  Toxicological sciences : an official journal of the Society of Toxicology 20110601

• A predictive ligand-based Bayesian model for human drug-induced liver injury.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Differential regulation of mitogen-activated protein kinase pathways by acetaminophen and its nonhepatotoxic regioisomer 3'-hydroxyacetanilide in TAMH cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20100701

• Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners.

  BMC chemical biology 20090101

• Differential gene expression analysis of a known hepatotoxin, N-acetyl-p-amino-phenol (APAP) as compared to its non-toxic analog, N-acetyl-m-amino-phenol (AMAP) in mouse liver.

  The Journal of toxicological sciences 20080501

• Development of an HPLC-MS/MS method for the selective determination of paracetamol metabolites in mouse urine.

  Analytical biochemistry 20080301

• Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses.

  Toxicological sciences : an official journal of the Society of Toxicology 20070901

• The reactive metabolite target protein database (TPDB)--a web-accessible resource.

  BMC bioinformatics 20070101

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Genotoxic activities of aniline and its metabolites and their relationship to the carcinogenicity of aniline in the spleen of rats.

  Critical reviews in toxicology 20051201

• Application of stable isotope labeled glutathione and rapid scanning mass spectrometers in detecting and characterizing reactive metabolites.

  Rapid communications in mass spectrometry : RCM 20050101

• Enzymatic synthesis of 3'-hydroxyacetaminophen catalyzed by tyrosinase.

  Biotechnology progress 20030101

• Cell culture model for acetaminophen-induced hepatocyte death in vivo.

  Biochemical pharmacology 20020801

• Enhanced acetaminophen hepatotoxicity in transgenic mice overexpressing BCL-2.

  Molecular pharmacology 20011101

• Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway.

  Molecular pharmacology 20011001

• Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry.

  Advances in experimental medicine and biology 20010101