622-78-6 | Benzyl isothiocyanate

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$23.00	$16.00
5g	98%	in stock	$36.00	$25.00
25g	98%	in stock	$98.00	$69.00
100g	98%	in stock	$251.00	$176.00
500g	98%	in stock	$760.00	$532.00

Description

• Catalog Number: AB45613
• Chemical Name: Benzyl isothiocyanate
• CAS Number: 622-78-6
• Molecular Formula: C8H7NS
• Molecular Weight: 149.2129
• MDL Number: MFCD00004819
• SMILES: S=C=NCc1ccccc1

Computed Properties

• Complexity: 132
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• XLogP3: 3.2

Literature

• Benzyl isothiocyanate attenuates the hydrogen peroxide-induced interleukin-13 expression through glutathione S-transferase P induction in T lymphocytic leukemia cells.

  Journal of biochemical and molecular toxicology 20180601

• Benzyl isothiocyanate ameliorates acetaldehyde-induced cytotoxicity by enhancing aldehyde dehydrogenase activity in murine hepatoma Hepa1c1c7 cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171001

• Development and application of a method for identification of isothiocyanate-targeted molecules in colon cancer cells.

  Analytical biochemistry 20121015

• Hepatoma-derived growth factor regulates breast cancer cell invasion by modulating epithelial--mesenchymal transition.

  The Journal of pathology 20121001

• Notch2 activation by benzyl isothiocyanate impedes its inhibitory effect on breast cancer cell migration.

  Breast cancer research and treatment 20120801

• Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120801

• Identifying and characterizing binding sites on the irreversible inhibition of human glutathione S-transferase P1-1 by S-thiocarbamoylation.

  Chembiochem : a European journal of chemical biology 20120723

• Enhancement of cisplatin cytotoxicity by benzyl isothiocyanate in HL-60 cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120701

• Contact and fumigant toxicity of Armoracia rusticana essential oil, allyl isothiocyanate and related compounds to Dermatophagoides farinae.

  Pest management science 20120501

• Molecular and life-history effects of a natural toxin on herbivorous and non-target soil arthropods.

  Ecotoxicology (London, England) 20120501

• First study on antimicriobial activity and synergy between isothiocyanates and antibiotics against selected Gram-negative and Gram-positive pathogenic bacteria from clinical and animal source.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20120501

• Optimized labeling of NOTA-conjugated octreotide with F-18.

  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20120401

• Content determination of benzyl glucosinolate and anti-cancer activity of its hydrolysis product in Carica papaya L.

  Asian Pacific journal of tropical medicine 20120301

• 3-Benzyl-6-methyl-2-sulfanylidene-2,3-di-hydroquinazolin-4(1H)-one.

  Acta crystallographica. Section E, Structure reports online 20120301

• Cytotoxicity of benzyl isothiocyanate in normal renal proximal tubular cells and its modulation by glutathione.

  Journal of agricultural and food chemistry 20120222

• Benzyl isothiocyanate (BITC) induces G2/M phase arrest and apoptosis in human melanoma A375.S2 cells through reactive oxygen species (ROS) and both mitochondria-dependent and death receptor-mediated multiple signaling pathways.

  Journal of agricultural and food chemistry 20120118

• Varied response of Spodoptera littoralis against Arabidopsis thaliana with metabolically engineered glucosinolate profiles.

  Plant physiology and biochemistry : PPB 20120101

• Benzyl isothiocyanate inhibits basal and hepatocyte growth factor-stimulated migration of breast cancer cells.

  Molecular and cellular biochemistry 20120101

• The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes.

  Journal of oncology 20120101

• Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3).

  BMC medicine 20120101

• α-Tocopherol sensitizes human leukemia HL-60 cells to apoptosis induced by benzyl isothiocyanate.

  Bioscience, biotechnology, and biochemistry 20120101

• Dual-wavelength imaging of tumor progression by activatable and targeting near-infrared fluorescent probes in a bioluminescent breast cancer model.

  PloS one 20120101

• Critical role of p53 upregulated modulator of apoptosis in benzyl isothiocyanate-induced apoptotic cell death.

  PloS one 20120101

• Herbivory by a Phloem-feeding insect inhibits floral volatile production.

  PloS one 20120101

• Benzyl isothiocyanate causes FoxO1-mediated autophagic death in human breast cancer cells.

  PloS one 20120101

• Antimicrobial activities of isothiocyanates against Campylobacter jejuni isolates.

  Frontiers in cellular and infection microbiology 20120101

• Nanoemulsions of cancer chemopreventive agent benzyl isothiocyanate display enhanced solubility, dissolution, and permeability.

  Journal of agricultural and food chemistry 20111214

• Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates.

  The British journal of nutrition 20111201

• Benzyl isothiocyanate sensitizes human pancreatic cancer cells to radiation by inducing apoptosis.

  International journal of molecular medicine 20111201

• Radiolabeled CCK/gastrin peptides for imaging and therapy of CCK2 receptor-expressing tumors.

  Amino acids 20111101

• Oral administration of benzyl-isothiocyanate inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice.

  Breast cancer research and treatment 20111101

• Characteristics of papaya seed oils obtained by extrusion-expelling processes.

  Journal of the science of food and agriculture 20111001

• Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin.

  Molecular nutrition & food research 20111001

• Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.

  The Journal of biological chemistry 20110923

• Engineering GST M2-2 for high activity with indene 1,2-oxide and indication of an H-site residue sustaining catalytic promiscuity.

  Journal of molecular biology 20110909

• Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic sarcoma U-2 OS cells.

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20110801

• Assessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene in C57BL/6J mice.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110801

• Synthesis and antiproliferative activity of novel α- and β-dialkoxyphosphoryl isothiocyanates.

  Bioorganic & medicinal chemistry letters 20110801

• In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.

  Pest management science 20110701

• Benzyl isothiocyanate inhibits epithelial-mesenchymal transition in cultured and xenografted human breast cancer cells.

  Cancer prevention research (Philadelphia, Pa.) 20110701

• The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics.

  Chemico-biological interactions 20110630

• Benzyl isothiocyanate (BITC) inhibits migration and invasion of human gastric cancer AGS cells via suppressing ERK signal pathways.

  Human & experimental toxicology 20110401

• Structural requirements for mutation formation from polycyclic aromatic hydrocarbon dihydrodiol epoxides in their interaction with food chemopreventive compounds.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110401

• Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110401

• Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways.

  Cell death & disease 20110401

• Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3.

  Carcinogenesis 20110301

• The roles of AIF and Endo G in the apoptotic effects of benzyl isothiocyanate on DU 145 human prostate cancer cells via the mitochondrial signaling pathway.

  International journal of oncology 20110301

• Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.

  Journal of medicinal chemistry 20110210

• Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells.

  Carcinogenesis 20110201

• MicroRNA-375 and MicroRNA-221: Potential Noncoding RNAs Associated with Antiproliferative Activity of Benzyl Isothiocyanate in Pancreatic Cancer.

  Genes & cancer 20110201

• Effectiveness of different solid-phase microextraction fibres for differentiation of selected Madeira island fruits based on their volatile metabolite profile--identification of novel compounds.

  Talanta 20110115

• Dietary phenethyl isothiocyanate alters gene expression in human breast cancer cells.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Medicinal plants used as antitumor agents in Brazil: an ethnobotanical approach.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells.

  PloS one 20110101

• Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells.

  PloS one 20110101

• Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2'-O-acetyl-α-L-rhamnosyloxy)benzyl]isothiocyanate from Moringa oleifera.

  Nutrition and cancer 20110101

• Benzyl isothiocyanate, a major component from the roots of Salvadora persica is highly active against Gram-negative bacteria.

  PloS one 20110101

• Dietary fat increases solid tumor growth and metastasis of 4T1 murine mammary carcinoma cells and mortality in obesity-resistant BALB/c mice.

  Breast cancer research : BCR 20110101

• Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors.

  PloS one 20110101

• Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/Rho-GTPases: pivotal role of STAT-3.

  PloS one 20110101

• Notch activation by phenethyl isothiocyanate attenuates its inhibitory effect on prostate cancer cell migration.

  PloS one 20110101

• Antiplasmodial Properties and Bioassay-Guided Fractionation of Ethyl Acetate Extracts from Carica papaya Leaves.

  Journal of parasitology research 20110101

• Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells.

  Clinical epigenetics 20110101

• Glutathione s-transferases in pediatric cancer.

  Frontiers in oncology 20110101

• Phytochemical and antifungal profiles of the seeds of carica papaya L.

  Indian journal of pharmaceutical sciences 20110101

• Determination of new biomarkers to monitor the dietary consumption of isothiocyanates.

  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20101201

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Analogues of morphanthridine and the tear gas dibenz[b,f][1,4]oxazepine (CR) as extremely potent activators of the human transient receptor potential ankyrin 1 (TRPA1) channel.

  Journal of medicinal chemistry 20101014

• Trypanocidal and antileukaemic effects of the essential oils of Hagenia abyssinica, Leonotis ocymifolia, Moringa stenopetala, and their main individual constituents.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20101001

• Evaluation of antibacterial activity of 3-butenyl, 4-pentenyl, 2-phenylethyl, and benzyl isothiocyanate in Brassica vegetables.

  Journal of food science 20100901

• Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells.

  The Journal of nutrition 20100801

• Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.

  Journal of medicinal chemistry 20100722

• Benzyl isothiocyanate-mediated inhibition of histone deacetylase leads to NF-kappaB turnoff in human pancreatic carcinoma cells.

  Molecular cancer therapeutics 20100601

• p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression.

  Cancer prevention research (Philadelphia, Pa.) 20100601

• Inhibition of human breast cancer xenograft growth by cruciferous vegetable constituent benzyl isothiocyanate.

  Molecular carcinogenesis 20100501

• Antimicrobial activity of phenolics and glucosinolate hydrolysis products and their synergy with streptomycin against pathogenic bacteria.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20100501

• New biomarkers for monitoring the levels of isothiocyanates in humans.

  Chemical research in toxicology 20100419

• Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.

  Bioorganic & medicinal chemistry letters 20100415

• Phytochemicals in cancer prevention and therapy: truth or dare?

  Toxins 20100401

• Benzyl isothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway.

  Journal of agricultural and food chemistry 20100310

• Chloroplastic phosphoadenosine phosphosulfate metabolism regulates basal levels of the prohormone jasmonic acid in Arabidopsis leaves.

  Plant physiology 20100301

• The toxic effects of benzyl glucosinolate and its hydrolysis product, the biofumigant benzyl isothiocyanate, to Folsomia fimetaria.

  Environmental toxicology and chemistry 20100201

• Immunochemical detection of food-derived isothiocyanate as a lysine conjugate.

  Bioscience, biotechnology, and biochemistry 20100101

• Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study.

  BMC cancer 20100101

• Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells.

  BMC cancer 20100101

• Molecular and cellular designs of insect taste receptor system.

  Frontiers in cellular neuroscience 20100101

• Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer.

  Journal of molecular signaling 20100101

• Ethnopharmacological survey among migrants living in the Southeast Atlantic Forest of Diadema, São Paulo, Brazil.

  Journal of ethnobiology and ethnomedicine 20100101

• Salvadora persica.

  Pharmacognosy reviews 20100101

• Prevention of mammary carcinogenesis in MMTV-neu mice by cruciferous vegetable constituent benzyl isothiocyanate.

  Cancer research 20091215

• Benzyl isothiocyanate exhibits anti-inflammatory effects in murine macrophages and in mouse skin.

  Journal of molecular medicine (Berlin, Germany) 20091201

• [Antimicrobial efficacy of benzyl isothiocyanate].

  Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20091201

• Benzyl isothiocyanate inhibits murine WEHI-3 leukemia cells in vitro and promotes phagocytosis in BALB/c mice in vivo.

  Leukemia research 20091101

• A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor.

  Biochemistry 20091020

• Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery.

  Biochemical and biophysical research communications 20091016

• Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells.

  Carcinogenesis 20091001

• Growth-inhibiting activities of phenethyl isothiocyanate and its derivatives against intestinal bacteria.

  Journal of food science 20091001

• Anti-proliferative and proapoptotic effects of benzyl isothiocyanate on human pancreatic cancer cells is linked to death receptor activation and RasGAP/Rac1 down-modulation.

  International journal of oncology 20090901

• Diverse chemicals including aryl hydrocarbon receptor ligands modulate transcriptional activity of the 3'immunoglobulin heavy chain regulatory region.

  Toxicology 20090630

• Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes.

  The Journal of biological chemistry 20090619

• Re: The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate.

  Journal of the National Cancer Institute 20090616

• Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents.

  Toxicology and applied pharmacology 20090615

• Degradation and sorption of 2-propenyl and benzyl isothiocyanate in soil.

  Environmental toxicology and chemistry 20090601

• Potency of isothiocyanates to induce luciferase reporter gene expression via the electrophile-responsive element from murine glutathione S-transferase Ya.

  Toxicology in vitro : an international journal published in association with BIBRA 20090601

• The antimicrobial effects of glucosinolates and their respective enzymatic hydrolysis products on bacteria isolated from the human intestinal tract.

  Journal of applied microbiology 20090601

• Benzyl isothiocyanate sensitizes human pancreatic cancer cells to radiation therapy.

  Frontiers in bioscience (Elite edition) 20090601

• Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells.

  British journal of cancer 20090505

• Enzyme activities and subcellular localization of members of the Arabidopsis glutathione transferase superfamily.

  Journal of experimental botany 20090301

• The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate.

  Journal of the National Cancer Institute 20090204

• Aurintricarboxylic acid inhibits influenza virus neuraminidase.

  Antiviral research 20090201

• Isothiocyanates repress estrogen receptor alpha expression in breast cancer cells.

  Oncology reports 20090101

• Isothiocyanate profile and selective antibacterial activity of root, stem, and leaf extracts derived from Raphanus sativus L.

  Foodborne pathogens and disease 20090101

• Phytochemical induction of cell cycle arrest by glutathione oxidation and reversal by N-acetylcysteine in human colon carcinoma cells.

  Nutrition and cancer 20090101

• Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC-1 cancer cells.

  Cancer cell international 20090101

• Differing mechanisms of simple nitrile formation on glucosinolate degradation in Lepidium sativum and Nasturtium officinale seeds.

  Phytochemistry 20090101

• (-)-Epigallocatechin-3-gallate potentiates the cytotoxicity induced by benzyl isothiocyanate and hydrogen peroxide in human Jurkat T lymphocytes.

  Bioscience, biotechnology, and biochemistry 20081101

• Inhibitory effect of fermented papaya preparation on hydroxyl radical generation from methylguanidine.

  Journal of clinical biochemistry and nutrition 20081101

• Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells.

  The Journal of biological chemistry 20081031

• Benzylglucosinolate, benzylisothiocyanate, and myrosinase activity in papaya fruit during development and ripening.

  Journal of agricultural and food chemistry 20081022

• Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles.

  Proceedings of the National Academy of Sciences of the United States of America 20081014

• ATP depletion alters the mode of cell death induced by benzyl isothiocyanate.

  Biochimica et biophysica acta 20081001

• Dietary isothiocyanate mediated apoptosis of human cancer cells is associated with Bcl-xL phosphorylation.

  International journal of oncology 20081001

• Cancer is a preventable disease that requires major lifestyle changes.

  Pharmaceutical research 20080901

• Suppressive Effects of Selected Food Phytochemicals on CD74 Expression in NCI-N87 Gastric Carcinoma Cells.

  Journal of clinical biochemistry and nutrition 20080901

• Benzyl isothiocyanate inhibits metalloproteinase-2/-9 expression by suppressing the mitogen-activated protein kinase in SK-Hep1 human hepatoma cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701

• Herbal compounds and toxins modulating TRP channels.

  Current neuropharmacology 20080301

• Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation.

  PloS one 20080101

• Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate.

  PloS one 20080101

• Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosis.

  BMC cancer 20080101

• Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells.

  Nutrition and cancer 20080101

• Modifying effects of dietary factors on (-)-epigallocatechin-3-gallate-induced pro-matrix metalloproteinase-7 production in HT-29 human colorectal cancer cells.

  Bioscience, biotechnology, and biochemistry 20071001

• Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents.

  Biological chemistry 20071001

• Formation and degradation kinetics of the biofumigant benzyl isothiocyanate in soil.

  Environmental science & technology 20070615

• Papaya seed represents a rich source of biologically active isothiocyanate.

  Journal of agricultural and food chemistry 20070530

• Selective cytotoxicity of benzyl isothiocyanate in the proliferating fibroblastoid cells.

  International journal of cancer 20070201

• Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis.

  Breast cancer research : BCR 20070101

• Comments regarding: Benzyl isothiocyanate (BITC) induces apoptosis in ovarian cancer cells in vitro Kalkunte S, Swamy N, Dizon DS, Brard L. J Exp Ther Oncol.5(4):287-300, 2006.

  Journal of experimental therapeutics & oncology 20070101

• p38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1.

  Biochemical and biophysical research communications 20061124

• Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak.

  Molecular cancer therapeutics 20061101

• Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters.

  Cancer letters 20060928

• Characterization of two Arabidopsis thaliana glutathione S-transferases.

  Plant cell reports 20060901

• Newly constructed stable reporter cell lines for mechanistic studies on electrophile-responsive element-mediated gene expression reveal a role for flavonoid planarity.

  Biochemical pharmacology 20060714

• Haplotype-environment interactions that regulate the human glutathione S-transferase P1 promoter.

  Cancer research 20060615

• Raphanus sativus and its isothiocyanates inhibit vascular smooth muscle cells proliferation and induce G(1) cell cycle arrest.

  International immunopharmacology 20060501

• Invasive plant suppresses the growth of native tree seedlings by disrupting belowground mutualisms.

  PLoS biology 20060501

• Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers.

  Carcinogenesis 20060401

• Effect of isothiocyanates on nuclear accumulation of NF-kappaB, Nrf2, and thioredoxin in caco-2 cells.

  Journal of agricultural and food chemistry 20060308

• The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells.

  Anti-cancer drugs 20060301

• Cell death induction by isothiocyanates and their underlying molecular mechanisms.

  BioFactors (Oxford, England) 20060101

• Benzyl isothiocyanate (BITC) induces apoptosis in ovarian cancer cells in vitro.

  Journal of experimental therapeutics & oncology 20060101

• Dietary isothiocyanates modify mitochondrial functions through their electrophilic reaction.

  Bioscience, biotechnology, and biochemistry 20051201

• Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.

  Current drug metabolism 20051001

• The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050901

• Modulation of jejunal contractions by extract of Carica papaya L. seeds.

  Phytotherapy research : PTR 20050701

• A novel function of benzyl isothiocyanate in vascular smooth muscle cells: the role of ERK1/2, cell cycle regulation, and matrix metalloproteinase-9.

  Journal of cellular physiology 20050601

• The identification of 1,3-oxazolidine-2-thiones and 1,3-thiazolidine-2-thiones from the reaction of glucose with benzyl isothiocyanate.

  Carbohydrate research 20050207

• Glutathione S-transferase Pi has at least three distinguishable xenobiotic substrate sites close to its glutathione-binding site.

  The Journal of biological chemistry 20041126

• Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eye.

  The Journal of biological chemistry 20041119

• Targeting of a head and neck squamous cell carcinoma xenograft model using the chimeric monoclonal antibody U36 radioiodinated with a closo-dodecaborate-containing linker.

  Acta oto-laryngologica 20041101

• Structure-activity relationship of S-benzylisothiourea derivatives to induce spherical cells in Escherichia coli.

  Bioscience, biotechnology, and biochemistry 20041101

• Do aberrant crypt foci have predictive value for the occurrence of colorectal tumours? Potential of gene expression profiling in tumours.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20041001

• Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20041001

• Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells.

  Carcinogenesis 20040901

• Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines.

  Experimental biology and medicine (Maywood, N.J.) 20040901

• Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040801

• Effects of benzyl-, phenethyl-, and alpha-naphthyl isothiocyanates on P-glycoprotein- and MRP1-mediated transport.

  Journal of pharmaceutical sciences 20040701

• Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro.

  Drug metabolism and disposition: the biological fate of chemicals 20040601

• Effect of benzyl isothiocyanate on spontaneous and induced force of rat uterine contraction.

  Pharmacological research 20040501

• Pregnancy outcomes following pre- and post-implantation exposure of Sprague-Dawley rats to benzyl isothiocyanate.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040501

• Benzyl isothiocyanate inhibits excessive superoxide generation in inflammatory leukocytes: implication for prevention against inflammation-related carcinogenesis.

  Carcinogenesis 20040401

• A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation.

  Cancer research 20040315

• In vitro digestion of sinigrin and glucotropaeolin by single strains of Bifidobacterium and identification of the digestive products.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040301

• Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N-acetyltransferase and glutathione S-transferase activities.

  Environmental and molecular mutagenesis 20040101

• Benzyl isothiocyanate modifies expression of the G2/M arrest-related genes.

  BioFactors (Oxford, England) 20040101

• Benzyl isothiocyanate inhibits oxidative stress in mouse skin: Involvement of attenuation of leukocyte infiltration.

  BioFactors (Oxford, England) 20040101

• Tocolytic and toxic activity of papaya seed extract on isolated rat uterus.

  Life sciences 20031219

• Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N-butyl-N-(4-hydroxybutyl)nitrosamine in rats after initiation.

  Cancer science 20031101

• Requirement of a carbon spacer in benzyl isothiocyanate-mediated cytotoxicity and MAPK activation in head and neck squamous cell carcinoma.

  Carcinogenesis 20031001

• Influence of plant and bacterial myrosinase activity on the metabolic fate of glucosinolates in gnotobiotic rats.

  The British journal of nutrition 20030801

• Naturally occurring Phe151Leu substitution near a conserved folding module lowers stability of glutathione transferase P1-1.

  Biochimica et biophysica acta 20030626

• Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-gamma-induced IkappaB degradation in RAW264.7 macrophages.

  Cancer letters 20030530

• Determination of amino acids in foods by reversed-phase HPLC with new precolumn derivatives, butylthiocarbamyl, and benzylthiocarbamyl derivatives compared to the phenylthiocarbamyl derivative and ion exchange chromatography.

  Molecular biotechnology 20030501

• Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats.

  Carcinogenesis 20030301

• Effects of garden and water cress juices and their constituents, benzyl and phenethyl isothiocyanates, towards benzo(a)pyrene-induced DNA damage: a model study with the single cell gel electrophoresis/Hep G2 assay.

  Chemico-biological interactions 20030106

• Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2.

  Nutrition and cancer 20030101

• Involvement of toxicity as an early event in urinary bladder carcinogenesis induced by phenethyl isothiocyanate, benzyl isothiocyanate, and analogues in F344 rats.

  Toxicologic pathology 20030101

• Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung.

  Cancer letters 20021210

• Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine.

  Pharmaceutical research 20021001

• Investigation of the tuber constituents of maca (Lepidium meyenii Walp.).

  Journal of agricultural and food chemistry 20020925

• Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.

  Carcinogenesis 20020901

• Chemoprotective effects of garden cress (Lepidium sativum) and its constituents towards 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ)-induced genotoxic effects and colonic preneoplastic lesions.

  Carcinogenesis 20020701

• Effects of papaya seed extract and benzyl isothiocyanate on vascular contraction.

  Life sciences 20020621

• Effect of naturally occurring organosulfur compounds on nitric oxide production in lipopolysaccharide-activated macrophages.

  Life sciences 20020614

• Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis.

  The Journal of biological chemistry 20020308

• Palladium(0)-catalyzed enantioselective O,S-rearrangement of racemic O-allylic thiocarbamates: a new entry to enantioenriched allylic sulfur compounds.

  The Journal of organic chemistry 20020222

• Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis.

  Cancer research 20020101

• Pyridazine derivatives and related compounds, part 9. tetrazolo[1,5-b]pyridazine-8-carbohydrazide: synthesis and some reactions.

  Bollettino chimico farmaceutico 20020101

• Simultaneous treatment with benzyl isothiocyanate, a strong bladder promoter, inhibits rat urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine.

  Nutrition and cancer 20020101

• 4-(Methylthio)-3-butenyl isothiocyanate, a principal antimutagen in daikon (Raphanus sativus; Japanese white radish).

  Journal of agricultural and food chemistry 20011201

• Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes.

  Chemical research in toxicology 20010901

• Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines.

  Cancer research 20010815

• Differential effects of naturally occurring isothiocyanates on the activities of cytochrome P450 2E1 and the mutant P450 2E1 T303A.

  Archives of biochemistry and biophysics 20010701

• Benzyl isothiocyanate is the chief or sole anthelmintic in papaya seed extracts.

  Phytochemistry 20010601

• Effects of benzyl isothiocyanate on rat and human cytochromes P450: identification of metabolites formed by P450 2B1.

  The Journal of pharmacology and experimental therapeutics 20010101

• Toxic effects of benzyl and allyl isothiocyanates and benzyl-isoform specific metabolites in the urinary bladder after a single intravesical application to rats.

  Toxicologic pathology 20010101

• Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1.

  The Biochemical journal 19981101

• Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.

  Cancer research 19980201

• Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE).

  Molecular medicine (Cambridge, Mass.) 19951101

• Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases.

  Biochemical and biophysical research communications 19950117