6228-73-5 | Cyclopropanecarboxamide

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$8.00	$5.00
25g	98%	in stock	$10.00	$7.00
50g	98%	in stock	$12.00	$8.00
100g	98%	in stock	$13.00	$10.00
500g	98%	in stock	$54.00	$38.00
1000g	98%	in stock	$65.00	$46.00

Description

• Catalog Number: AB72412
• Chemical Name: Cyclopropanecarboxamide
• CAS Number: 6228-73-5
• Molecular Formula: C4H7NO
• Molecular Weight: 85.1045
• MDL Number: MFCD00013729
• SMILES: NC(=O)C1CC1
• NSC Number: 402033

Computed Properties

• Complexity: 75.6
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 6
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: -0.4

Literature

• Discovery of (1R,2S)-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist.

  Journal of medicinal chemistry 20150611

• Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.

  Bioorganic & medicinal chemistry letters 20130301

• Multi-component anion relay cascade of 1-acetylcyclopropanecarboxamides, aldehydes and acrylonitrile: access to biscyanoethylated furo[3,2-c]pyridinones.

  Organic & biomolecular chemistry 20120621

• Highly asymmetric intramolecular cyclopropanation of acceptor-substituted diazoacetates by Co(II)-based metalloradical catalysis: iterative approach for development of new-generation catalysts.

  Journal of the American Chemical Society 20111005

• Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20110915

• Ursodeoxycholic acid amides as novel glucocorticoid receptor modulators.

  Journal of medicinal chemistry 20110113

• Identification of a new biaryl scaffold generating potent renin inhibitors.

  Bioorganic & medicinal chemistry letters 20101001

• Synthesis, antifungal activities and 3D-QSAR study of N-(5-substituted-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamides.

  European journal of medicinal chemistry 20090701

• Synthesis and biological evaluation of cis-locked vinylogous combretastatin-A4 analogues: derivatives with a cyclopropyl-vinyl or a cyclopropyl-amide bridge.

  Bioorganic & medicinal chemistry letters 20090301

• Potential energy scans and vibrational assignments of cyclopropanecarboxylic acid and cyclopropanecarboxamide.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081215

• Effect of Maillard reacted peptides on human salt taste and the amiloride-insensitive salt taste receptor (TRPV1t).

  Chemical senses 20080901

• Modifications of antiepileptic drugs for improved tolerability and efficacy.

  Perspectives in medicinal chemistry 20080101

• Bradykinin B1 antagonists: biphenyl SAR studies in the cyclopropanecarboxamide series.

  Bioorganic & medicinal chemistry letters 20070701

• Design, synthesis and melatoninergic potency of new N-acyl 8,9-dihydro-4-methoxy-7H-2-benzo[de]quinolinalkanamines.

  Bioorganic chemistry 20070401

• High affinity electrophilic and photoactivatable covalent endocannabinoid probes for the CB1 receptor.

  Journal of medicinal chemistry 20051006

• Convergent approach to (E)-alkene and cyclopropane peptide isosteres.

  Organic letters 20050106

• Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck).

  Bioorganic & medicinal chemistry letters 20031117

• Sequential elimination-cyclopropanation reactions promoted by samarium: highly diastereoselective synthesis of cyclopropylamides.

  The Journal of organic chemistry 20030207

• Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists.

  Bioorganic & medicinal chemistry letters 20010423